CN109512467A - Tear lipid detects dewatering nano silica test paper and preparation method thereof - Google Patents
Tear lipid detects dewatering nano silica test paper and preparation method thereof Download PDFInfo
- Publication number
- CN109512467A CN109512467A CN201811191226.9A CN201811191226A CN109512467A CN 109512467 A CN109512467 A CN 109512467A CN 201811191226 A CN201811191226 A CN 201811191226A CN 109512467 A CN109512467 A CN 109512467A
- Authority
- CN
- China
- Prior art keywords
- paper
- test paper
- nano silica
- paper slip
- dewatering nano
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 title claims abstract description 55
- 150000002632 lipids Chemical class 0.000 title claims abstract description 35
- 239000000377 silicon dioxide Substances 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title claims description 14
- 238000001514 detection method Methods 0.000 claims abstract description 24
- 239000006185 dispersion Substances 0.000 claims abstract description 13
- 239000007788 liquid Substances 0.000 claims abstract description 9
- 238000010521 absorption reaction Methods 0.000 claims abstract description 8
- 239000000463 material Substances 0.000 claims abstract description 8
- 238000007711 solidification Methods 0.000 claims abstract description 7
- 230000008023 solidification Effects 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 6
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 5
- 239000012153 distilled water Substances 0.000 claims abstract description 5
- 230000001954 sterilising effect Effects 0.000 claims abstract description 5
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 claims abstract description 4
- 238000001035 drying Methods 0.000 claims abstract description 4
- 238000007605 air drying Methods 0.000 claims description 4
- 239000000835 fiber Substances 0.000 claims description 3
- 210000004175 meibomian gland Anatomy 0.000 abstract description 7
- 239000000284 extract Substances 0.000 abstract description 5
- 230000028327 secretion Effects 0.000 abstract description 3
- 238000000605 extraction Methods 0.000 abstract description 2
- 238000000034 method Methods 0.000 description 2
- 241001608562 Chalazion Species 0.000 description 1
- 241000150100 Margo Species 0.000 description 1
- 206010065062 Meibomian gland dysfunction Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 210000000795 conjunctiva Anatomy 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 210000000744 eyelid Anatomy 0.000 description 1
- 125000003473 lipid group Chemical group 0.000 description 1
- 230000003075 superhydrophobic effect Effects 0.000 description 1
- 210000000457 tarsus Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
- A61B2010/0067—Tear or lachrymal fluid
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Hematology (AREA)
- Pathology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Eye Examination Apparatus (AREA)
Abstract
The dewatering nano silica test paper of tear lipid detection, test paper are elongated rectangle paper slip, and paper slip is vertically arranged graduation mark by a long side, and a short side setting folding line is parallel on test paper and is marked.The step of it is prepared are as follows: the 1) paper for choosing oil absorption material is cut to rectangle paper slip；2) paper slip in step 1) is soaked in dewatering nano silica dispersions, dispersion liquid is made to be thoroughly impregnated paper slip；3) paper slip impregnated is taken out, is made it dry；4) paper slip after drying is placed in the solidification of incubator high temperature；5) remaining reagent on paper slip after making to remove hot setting wash with distilled water, becomes the dewatering nano silica test paper of tear lipid detection；6) it will be saved after the sterilizing of obtained test paper ethane via epoxyethane.It is expensive, extraction Meibomian gland lipid complicated for operation that the present invention can solve existing lipid detection device, and existing tear Test paper can only extract tear moisture, can not extract the technical issues of lipid of Meibomian gland secretion.
Description
Technical field
The present invention relates to the technical field of tear lipid detection, specially tear lipid detection dewatering nano silica examinations
Paper and preparation method thereof.
Background technique
Meibomian gland buries among upper tarsus inferior, and opening is located at margo palpebrae, and the lipid secretions of discharge form the table of tear film
Layer, lipid components can prevent tear excessive evaporation.Meibomian gland dysfunction is a kind of common disease of eyes, be there is also sometimes
Chalazion, some column problems such as Meibomian gland blocking.Clinical manifestation is that eyes are dry and astringent, pain.Serious person can also cause eyes
Hypopsia.
Research papers include:
[1] Wang Yuqian, Dong Nuo, Wu's shield is flat, the morphologic progress of Meibomian gland [J], " Chinese Journal of Ophthalmology ", and 2014,
50(4):299-302
[2] Gao Yan, infrared ray Meibomian gland instrument observe [J] to meibomian gland dysfunction Patient Global before and after treatment, and " China is real
With ophthalmology magazine ", 2016,34 (11)
[3] application value [J] of Yang Kan, LipiView the eye surface interferometer in meibomian gland dysfunction diagnosis, " China
TCM Ophthalmology magazine ", 2017,27 (4): 260-262
[4] Liang Qingfeng, different type dry eye patients Tear Film Lipid Layer Thickness and its relationship [J] with Clinical symptoms, " China
Test ophthalmology magazine ", 2018 (2): 124-129
It is mainly currently on the market plate gland scope, eye surface interferometer, laser living body for the inspection of Meibomian gland function
Laser Scanning Confocal Microscope etc..Although can obtain above these types currently on the market can be used for the instrument of Meibomian gland inspection, face
Experience still relied on more for the judgement of Meibomian gland function on bed, existing instrument there are the problem of valuable lattice costly, need profession
Personnel's operation etc. is unfavorable for the universal of Meibomian gland functional check.
In addition be now used clinically for the measurements such as " tears detecting filter strip ", " the phenol red cotton thread " of Schimer's test is
The amount of the tear of lacrimal secretion, collection be lacrimal secretion moisture, it is therefore an objective to assess the secreting function of lachrymal gland, and can not collect
The lipid of Meibomian gland secretion does not act on the assessment of Meibomian gland function.
Summary of the invention
The present invention provides a kind of tear lipid detection dewatering nano silica test paper and preparation method thereof, can solve existing
It is expensive, extraction Meibomian gland lipid complicated for operation there is lipid detection device, and existing tear Test paper can only extract tear
Liquid moisture can not extract the technical issues of lipid of Meibomian gland secretion.
The following technical solution is employed: the dewatering nano silica test paper of tear lipid detection, the examination by the present invention
Paper is elongated rectangle paper slip, and the paper slip is vertically arranged graduation mark by a long side, a short side is parallel on the test paper
Folding line is arranged to mark.
Preferably, a short side of the paper slip is zero groove, and distance is to be arranged parallel at 3mm from zero groove
The folding line of zero groove marks.
The preparation method of the dewatering nano silica test paper of tear lipid detection, comprising the following steps:
1) paper for choosing oil absorption material, is cut to rectangle paper slip；
2) paper slip in step 1) is soaked in dewatering nano silica dispersions, dispersion liquid is made to be thoroughly impregnated paper
Item；
3) paper slip impregnated in step 2) by dispersion liquid is taken out, is made it dry；
4) paper slip after will be dry in step 3) is placed in the solidification of incubator high temperature；
5) remaining reagent on paper slip after making to remove hot setting wash with distilled water becomes the detection of tear lipid and uses
Dewatering nano silica test paper；
6) it will be saved after the sterilizing of test paper ethane via epoxyethane obtained in step 5).
Preferably, the paper slip width in step 1) is 0.5~2mm, and length is 30~50mm.
Preferably, the paper slip width in step 1) is 1mm, a length of 30mm.
Preferably, the drying mode in step 3) is to stand at least 10 minutes, makes its natural air drying；
Preferably, the solidification temperature in step 4 is 60 degrees Celsius, Shi Changwei 1 hour.
Preferably, the paper of the oil absorption material selects flaxen fiber.
The present invention has a following positive beneficial effect: the present invention extracts the lipid in tear using test paper, have it is easy to operate,
The features such as low cost.
The test paper uses dewatering nano silica dioxide coating, has the characteristics that super oleophylic, super-hydrophobic, test paper preparation convenience,
It is simple and easy to get, it realizes and only the lipid components in tear is adsorbed with the collection, it can be achieved that lipid when detecting tear, with
Research for subsequent detection Meibomian gland function provides basis.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of tear lipid detection dewatering nano silica test paper of the invention.
Accompanying drawing number: zero groove of 1-, 2- graduation mark, 3- folding line label.
Specific embodiment
The following further describes the specific embodiments of the present invention with reference to the drawings.
Following embodiment is only examples made by the present invention to clearly illustrate, and not to the limit of embodiments of the present invention
It is fixed.For those of ordinary skill in the art, it is various forms of that other can also be made on the basis of the following description
Variation changes, and these belong to obvious changes or variations that spirit of that invention is drawn still in protection of the invention
Among range.
Referring to Fig. 1, the dewatering nano silica test paper of tear lipid detection, the test paper is elongated rectangular paper
Item, the paper slip are vertically arranged graduation mark 2 by a long side, and a short side setting folding line label 3 is parallel on the test paper.
Further, a short side of the paper slip is zero groove 1, and distance is that setting is flat at 3mm from zero groove 1
Row is in the folding line label 3 of zero groove 1.
The preparation method of the dewatering nano silica test paper of tear lipid detection, comprising the following steps:
1) paper for choosing oil absorption material, is cut to rectangle paper slip；
2) paper slip in step 1) is soaked in dewatering nano silica dispersions, dispersion liquid is made to be thoroughly impregnated paper
Item；
3) paper slip impregnated in step 2) by dispersion liquid is taken out, is made it dry；
4) paper slip after will be dry in step 3) is placed in the solidification of incubator high temperature；
5) remaining reagent on paper slip after making to remove hot setting wash with distilled water becomes the detection of tear lipid and uses
Dewatering nano silica test paper；
6) it will be saved after the sterilizing of test paper ethane via epoxyethane obtained in step 5).
Further, the paper slip width in step 1) is 0.5~2mm, and length is 30~50mm.
Further, the paper slip width in step 1) is 1mm, a length of 30mm.
Further, the drying mode in step 3) is to stand at least 10 minutes, makes its natural air drying；
Further, the solidification temperature in step 4 is 60 degrees Celsius, Shi Changwei 1 hour.
Further, the paper of the oil absorption material selects flaxen fiber.
Embodiment
The preparation of test paper:
1) the good paper material of oil absorption is chosen, the rectangle of 1mm × 30mm is cut to；
2) paper slip is soaked in dewatering nano silica dispersions, dispersion liquid is made to be impregnated with paper slip；
3) it takes out to its natural air drying 10min；
4) solidify 1h in 60 DEG C of incubator high temperatures；
5) make to remove the remaining reagent on test paper wash with distilled water；
6) it is saved after ethylene oxide sterilizing.
Application Example
The step of extracting tear lipid using this patent test paper:
1) patient is advised to take seat；
2) examiner folds (i.e. at folding line label 3) at the 3mm of test paper one end, and expansion keeps folded end and tail end shape in 90 °
Angle clamps test paper using tweezers, it is intracapsular that folded end is placed in patient's lower tarsal conjunctiva；
3) Second eye takes same method to place test paper；
4) after 10min, eyelid is gently pulled down, takes out test paper, is i.e. completion lipid is collected.
Claims (8)
1. the dewatering nano silica test paper of tear lipid detection, which is characterized in that the test paper is elongated rectangle
Paper slip, the paper slip are vertically arranged graduation mark by a long side；A short side setting folding line is parallel on the test paper to mark.
2. the dewatering nano silica test paper of tear lipid detection as described in claim 1, which is characterized in that the paper
One short side of item is zero groove, and distance is the folding line label that zero groove is arranged parallel at 3mm from zero groove.
3. the preparation method of the dewatering nano silica test paper of tear lipid detection, which comprises the following steps:
1) paper for choosing oil absorption material, is cut to rectangle paper slip；
2) paper slip in step 1) is soaked in dewatering nano silica dispersions, dispersion liquid is made to be thoroughly impregnated paper slip；
3) paper slip impregnated in step 2) by dispersion liquid is taken out, is made it dry；
4) paper slip after will be dry in step 3) is placed in the solidification of incubator high temperature；
5) remaining reagent on paper slip after making to remove hot setting wash with distilled water becomes dredging for tear lipid detection
Water nano silica test paper；
6) it will be saved after the sterilizing of test paper ethane via epoxyethane obtained in step 5).
4. the preparation method of the dewatering nano silica test paper of tear lipid detection as claimed in claim 3, feature
It is, the paper slip width in step 1) is 0.5~2mm, and length is 30~50mm.
5. the preparation method of the dewatering nano silica test paper of tear lipid detection as claimed in claim 3, feature
It is, the paper slip width in step 1) is 1mm, a length of 30mm.
6. the preparation method of the dewatering nano silica test paper of tear lipid detection as claimed in claim 3, feature
It is, the drying mode in step 3) is to stand at least 10 minutes, makes its natural air drying.
7. the preparation method of the dewatering nano silica test paper of tear lipid detection as claimed in claim 3, feature
It is, the solidification temperature in step 4 is 60 degrees Celsius, Shi Changwei 1 hour.
8. the preparation method of the dewatering nano silica test paper of tear lipid detection as claimed in claim 3, feature
It is, the paper of the oil absorption material selects flaxen fiber.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811191226.9A CN109512467B (en) | 2018-10-12 | 2018-10-12 | Tear lipid detection hydrophobic nano silicon dioxide test paper and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811191226.9A CN109512467B (en) | 2018-10-12 | 2018-10-12 | Tear lipid detection hydrophobic nano silicon dioxide test paper and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109512467A true CN109512467A (en) | 2019-03-26 |
| CN109512467B CN109512467B (en) | 2024-07-19 |
Family
ID=65771970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811191226.9A Active CN109512467B (en) | 2018-10-12 | 2018-10-12 | Tear lipid detection hydrophobic nano silicon dioxide test paper and preparation method thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN109512467B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023061471A1 (en) * | 2021-10-15 | 2023-04-20 | 上海微银生物技术有限公司 | Tear glucose test device and production process therefor |
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| WO1991002980A1 (en) * | 1989-08-24 | 1991-03-07 | Ramsey Foundation | Method and apparatus for the measurement of organic antigens |
| WO2007058383A2 (en) * | 2005-11-17 | 2007-05-24 | Senju Pharmaceutical Co., Ltd. | Lipid secretion promoter containing lacritin or compound having lacritin activity |
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| CN105735047A (en) * | 2016-02-01 | 2016-07-06 | 东南大学 | Preparation method of conductive and super-hydrophobic functional graphene paper |
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| US20170280992A1 (en) * | 2014-06-06 | 2017-10-05 | Abbott Medical Optics Inc. | Fast absolute-reflectance method for the determination of tear film lipid layer thickness |
| CN107737946A (en) * | 2017-10-11 | 2018-02-27 | 南京工业大学 | Efficient preparation method of nano-micron metal material based on fiber paper material |
-
2018
- 2018-10-12 CN CN201811191226.9A patent/CN109512467B/en active Active
Patent Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991002980A1 (en) * | 1989-08-24 | 1991-03-07 | Ramsey Foundation | Method and apparatus for the measurement of organic antigens |
| WO2007058383A2 (en) * | 2005-11-17 | 2007-05-24 | Senju Pharmaceutical Co., Ltd. | Lipid secretion promoter containing lacritin or compound having lacritin activity |
| US20100113901A1 (en) * | 2008-10-24 | 2010-05-06 | Jin Zhang | Contact lens integrated with a biosensor for the detection of glucose and other components in tears |
| CN104094114A (en) * | 2011-11-30 | 2014-10-08 | 黛尔格诺斯蒂尔有限公司 | Method and assembly for mounting components on beams |
| WO2015163821A1 (en) * | 2014-04-23 | 2015-10-29 | Singapore Health Services Pte Ltd | Monitoring and/or detecting meibomian gland dysfunction |
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| CN105214344A (en) * | 2015-09-22 | 2016-01-06 | 山东交通学院 | A kind of super-hydrophobic super-oleophylic oil-water separation mesh film with self-cleaning function and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023061471A1 (en) * | 2021-10-15 | 2023-04-20 | 上海微银生物技术有限公司 | Tear glucose test device and production process therefor |
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| Publication number | Publication date |
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| CN109512467B (en) | 2024-07-19 |
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