CN109465047B - The portable clamping device of nano-pore detection chip - Google Patents
The portable clamping device of nano-pore detection chip Download PDFInfo
- Publication number
- CN109465047B CN109465047B CN201811328020.6A CN201811328020A CN109465047B CN 109465047 B CN109465047 B CN 109465047B CN 201811328020 A CN201811328020 A CN 201811328020A CN 109465047 B CN109465047 B CN 109465047B
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- CN
- China
- Prior art keywords
- chip
- liquid pool
- gripper
- catch bar
- nano
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
- B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/50—Clamping means, tongs
Abstract
The invention discloses a kind of portable clamping devices of nano-pore detection chip, including spring, catch bar, along the free-moving left liquid pool of catch bar, rubber washer, chip gripper and right liquid pool, left liquid pool and right liquid pool are separated by pressing catch bar, chip gripper equipped with chip is inserted into the gap between two liquid pools, when the external force that removal applies catch bar, right liquid pool and left liquid pool clamp chip gripper jointly under the action of the spring；Rubber washer on the inside of chip gripper guarantees sealed connection when clamping chip, and the rubber washer on the outside of chip gripper guarantees and the sealed connection of two liquid pools.The present invention utilizes the characteristic of spring spontaneous restoration, the positioning and clamping when two liquid pools are connect with chip can convenient and efficient, be accurately and efficiently realized, to realize chip needed for quick-replaceable.
Description
Technical field
The present invention relates to chip clamping device more particularly to the portable clamping devices of nano-pore detection chip.
Background technique
With the rise of forth generation sequencing technologies, the research of nano-pore detection technique senses biomolecule and detects neck
The development in domain has far-reaching influence.Laboratory apparatus is improved with device, simplified experimental procedure for improving conventional efficient, accelerating to grind
Study carefully process to have a very important significance.
Currently, the device of clamping nano-pore chip is mainly by two shape differences, one convex one recessed to realize one in laboratory
The liquid pool of positioning in a mobile dimension for the rubber washer of sealing, the outer bolt frame for clamping liquid pool and tightens spiral shell
The several part compositions of bolt.Its clamping step is main are as follows: 1, be placed in chip on the rubber washer being sticked on liquid pool simultaneously with tweezers
It is positioned by range estimation；2, another liquid pool for being stained with washer is buckled on chip, is positioned by range estimation and is clamped in advance with hand；3, will
Two liquid pools are placed on outer bolt frame, and bolt, which is tightened, makes its axial movement compress two liquid pools.
The device of above-mentioned clamping nano-pore in operation convenience, positioning accuracy, generally existing in terms of reliability several ask
Topic: 1, in terms of convenience, will first outwell the solution in liquid pool when using chip instead every time, then looser a bolt, after taking out liquid pool
Liquid pool could be separated and take out chip, installation process is more cumbersome.2, in terms of positioning accuracy, either chip or liquid pool is all needed
It is positioned by range estimation, though liquid pool has tongue and groove used for positioning, there are one dimensions to need to go out by range estimation positioning
Existing position inaccurate causes experiment because there is large error due to failure.3, in terms of reliability, chip is exposed to outer when replacing chip
In boundary's environment, this easily pollutes chip even destroy in the process, causes irremediable influence to experiment.4, Ren Yuancao
It is required, due to chip very little, need to carefully place it in washer center with tweezers to guarantee good leakproofness and positioning
Accuracy.Meanwhile dynamics requires have a certain range when being tightened with bolt: leakproofness difference, which occurs, in Ruo Taisongyi leads to showing for leakage
As；Easily make the SiN on chip if too tightxFilm crushing and lead to chip rejection.
Problem above makes experimentation complexity cumbersome, the decline of experimental result accuracy, more demanding to the operation of personnel,
It greatly affected conventional efficient, dragged slowly flow of research.
Summary of the invention
Goal of the invention: in order to overcome the shortcomings of above-mentioned existing nano-pore chip clamping device, the present invention provides one kind to receive
The portable clamping device of metre hole detection chip, it is small in size easy to carry, and energy is convenient and efficient, accurately and efficiently completes two liquid pools
Positioning and clamping when connecting with chip simplify operating procedure, shorten the chip clamping time, improve conventional efficient.
Technical solution: the present invention devises a kind of chip gripper dedicated for chip placement first, have thereon for realizing
Chip gripper clamps the buckle of chip, while having for hand-held tabs, and only needing to change clamping to replacement chip has corresponding core
The chip gripper of piece.The design of liquid pool portion is that catch bar is fixedly connected with across a liquid pool with another liquid pool.Catch bar with
Pressing spring is placed between non-connected liquid pool, makes the spontaneous clamping of two liquid pools using spring force.In addition to spring and rubber washer, own
Material selects PMMA.In use, chip is placed in chip gripper first, buckling well chip gripper buckle is clamped chip.It
The tabs of latter hand-held chip gripper, another hand press catch bar and overcome spring force to separate two liquid pools and generate enough
Big gap.Finally the chip that clamping has chip is folded in the gap between two liquid pools, by the locating plate on liquid pool into
The hand for pressing catch bar is unclamped after row positioning, liquid pool is made to generate the trend for restoring former clamped condition, dress under spring force effect
The chip gripper for accompanying chip is also clamped between two liquid pools therewith.
Working principle: the present invention makes the spontaneous clamping chip gripper of two liquid pools and internal nano-pore by the elastic force that spring applies
Chip achievees the purpose that quickly and conveniently to load and unload during nano-pore test experience, uses required chip instead.
The utility model has the advantages that compared with the prior device compared with the present invention is first put small chip by additional chip gripper indirectly
Greatly, can directly chip be moved and is replaced with hand-held, process no longer needs to use tweezers later.In positioning, the utility model dress
Setting can be accurately positioned and be consolidated by six-freedom degree of the locating plate on liquid pool to the chip gripper being clamped between two liquid pools
It is fixed, without estimating positioning.In handling, only a hand is needed to press the separation that catch bar achieves that liquid pool, after chip gripper of having good positioning
The spring that need to only loose one's grip can make the spontaneous clamping of two liquid pools, tighten liquid pool compared to helping manually and rotating bolt, the operation is more
It is simple and fast.In reliability, the program reduces the extraneous chance directly contacted with chip, only needs to change dress to replacement chip
The chip gripper of respective chip is accompanied, the pollution to chip can be largely reduced and even destroy.Its is small in size by the present invention
It is easy to carry.
Using above-mentioned new device, can facilitating chip clamping step, chip needed for quick-replaceable, and benefit during the experiment
Positioning accuracy and reliability when making the spontaneous clamping of two liquid pools with the characteristic that spring restores, and improving clamping.This is for subtracting
Short experimental period, raising Efficiency are of great significance.
Detailed description of the invention
Fig. 1 is assembling structure schematic diagram of the invention；
Fig. 2 is the assembly explosion diagram of chip gripper part；
Fig. 3 is that chip gripper is not loaded between liquid pool, and different angle when catch bar is pressed, liquid pool is in discrete state
Perspective view；
Fig. 4 is the schematic diagram that chip gripper is packed between liquid pool.
Specific embodiment
With reference to the accompanying drawing with specific embodiment, present invention is further described in detail:
As shown in Figure 1, the present invention is by spring 1, catch bar 2, left liquid pool 3, rubber washer 4, chip gripper 5,6 groups of right liquid pool
At.1 set of spring is clearance fit to guarantee left liquid pool 3 on catch bar 2 and in compressive state, between catch bar 2 and left liquid pool 3
It can be moved freely along catch bar 2, be interference fitted between catch bar 2 and right liquid pool 6 and combine gluing to guarantee that the two is fixedly connected with.
In addition to spring 1 and rubber washer 4, all material is all made of organic glass PMMA.When there is no external force to press catch bar 2, with promotion
The right liquid pool 6 that bar 2 is fixedly connected with generates the power in 3 direction of liquid pool to the left under the action of 1 elastic force of spring, makes left liquid pool 3 and right liquid pool 6
Between chip gripper 5 be clamped.Rubber washer 4 is for guaranteeing the good leakproofness in device junction.
As shown in Fig. 2, 4 rubber washers 4 use gluing in the two sides of 5 two parts of chip gripper respectively, wherein the two of inside
A rubber washer 4 is used to guarantee sealed connection when clamping nano-pore chip 7, and two rubber washers 4 in outside are respectively used to protect
The sealed connection of card and left liquid pool 3 and right liquid pool 6.On chip gripper 5 design have buckle, can by two parts of chip gripper 5 and its it
Between rubber washer 4 and chip 7 be closely together.
As shown in figure 3, chip gripper 5 is not loaded between liquid pool, and catch bar 2 is pressed, left liquid pool 3 and right liquid pool 6 are in
Discrete state.It can be seen that avoid and chip gripper on the locating plate and right liquid pool 6 of positioning chip folder 5 on left liquid pool 3
Buckle interference on 5 and the notch opened.
In use, first by chip 7 with tweezers be placed in on the rubber washer 4 of a piece of 5 inside adhesion of chip gripper, then
Another chip gripper 5 is buckled on the rubber washer 4 for being placed with chip 7, buckling well chip gripper buckle is clamped chip 7.It is latter
The only tabs of hand-held chip gripper 5, another hand press catch bar 2 and 1 elastic force of spring are overcome to separate left liquid pool 3 and right liquid pool 6
And generate sufficiently large gap.The chip gripper 5 that clamping has chip 7 is finally placed in the gap between left liquid pool 3 and right liquid pool 6
In, the hand for pressing catch bar 2 is unclamped after being positioned by the locating plate on left liquid pool 3, makees right liquid pool 6 in 1 elastic force of spring
With the lower trend for generating the former clamped condition of recovery, clamping has the chip gripper 5 of chip 7 to be also clamped at left liquid pool 3 and right liquid therewith
Between pond 6.
Claims (6)
1. a kind of portable clamping device of nano-pore detection chip, including spring (1), catch bar (2), along catch bar (2) from
By mobile left liquid pool (3), rubber washer (4), chip gripper (5) and right liquid pool (6), it is characterised in that: the catch bar (2) is worn
It crosses left liquid pool (3) to be fixedly connected with right liquid pool (6), separates left liquid pool (3) and right liquid pool (6) by pressing catch bar (2), will fill
There is the chip gripper (5) of chip to be inserted into the gap between two liquid pools, when removing the external force applied to catch bar (2), right liquid pool (6) and
Left liquid pool (3) clamps chip gripper (5) jointly under the action of the spring；The rubber washer (4) on the inside of chip gripper (5) is protected
Card clamps sealed connection when chip, is located at the sealed connection of rubber washer (4) guarantee and two liquid pools on the outside of chip gripper (5).
2. the portable clamping device of nano-pore detection chip according to claim 1, it is characterised in that: the left liquid pool
(3) there is the locating plate for positioning chip folder (5) on.
3. the portable clamping device of nano-pore detection chip according to claim 1, it is characterised in that: the chip gripper
(5) on design have buckle, by two parts of chip gripper (5) and its between rubber washer (4) and chip (7) be closely together.
4. the portable clamping device of nano-pore detection chip according to claim 3, it is characterised in that: the right liquid pool
(6) it is equipped with the notch that avoids interferenceing with the buckle on chip gripper (5) and open.
5. special according to claim 1 to the portable clamping device of nano-pore detection chip described in any one of 4 claims
Sign is: the catch bar (2), left liquid pool (3), chip gripper (5) and right liquid pool (6) material are organic glass PMMA.
6. special according to claim 1 to the portable clamping device of nano-pore detection chip described in any one of 4 claims
Sign is: making the spontaneous clamping of two liquid pools using the characteristic that spring restores.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811328020.6A CN109465047B (en) | 2018-11-06 | 2018-11-06 | The portable clamping device of nano-pore detection chip |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811328020.6A CN109465047B (en) | 2018-11-06 | 2018-11-06 | The portable clamping device of nano-pore detection chip |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109465047A CN109465047A (en) | 2019-03-15 |
| CN109465047B true CN109465047B (en) | 2019-07-30 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811328020.6A Active CN109465047B (en) | 2018-11-06 | 2018-11-06 | The portable clamping device of nano-pore detection chip |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112522085B (en) * | 2020-12-01 | 2022-05-31 | 合肥国研汉因检测科技有限公司 | Gene detection device based on solid-state nanopore |
| CN114164087A (en) * | 2021-11-26 | 2022-03-11 | 东南大学 | Portable chip clamping device |
| CN114713309B (en) * | 2022-03-23 | 2023-11-03 | 上海科技大学 | Sample stage applied to ultra-high vacuum and ultra-low temperature environment |
| CN114705743A (en) * | 2022-04-01 | 2022-07-05 | 南京师范大学 | Experimental device and experimental method based on nanopores |
Citations (7)
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|---|---|---|---|---|
| WO1997044132A1 (en) * | 1996-05-23 | 1997-11-27 | Microsensor Technology, Inc. | Housing assembly for micromachined fluid handling structure |
| CN101223434A (en) * | 2005-05-16 | 2008-07-16 | 霍尼韦尔国际公司 | Cytometer analysis cartridge optical configuration |
| CN101349672A (en) * | 2008-09-12 | 2009-01-21 | 福州大学 | Microflow control chip electrochemical detection device capable of accurately controlling electrode distance |
| CN103501907A (en) * | 2011-01-10 | 2014-01-08 | 伊鲁米那股份有限公司 | Systems, methods, and apparatuses to image a sample for biological or chemical analysis |
| CN205710714U (en) * | 2016-06-23 | 2016-11-23 | 北京普若博升生物科技有限公司 | A kind of nano-pore chip fixture |
| WO2017096296A1 (en) * | 2015-12-04 | 2017-06-08 | President And Fellows Of Harvard College | Clamping system for a microfluidic assembly |
| CN206383074U (en) * | 2017-01-04 | 2017-08-08 | 原子高科医药有限公司 | A kind of adjustable grip device of clamping force |
-
2018
- 2018-11-06 CN CN201811328020.6A patent/CN109465047B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997044132A1 (en) * | 1996-05-23 | 1997-11-27 | Microsensor Technology, Inc. | Housing assembly for micromachined fluid handling structure |
| CN101223434A (en) * | 2005-05-16 | 2008-07-16 | 霍尼韦尔国际公司 | Cytometer analysis cartridge optical configuration |
| CN101349672A (en) * | 2008-09-12 | 2009-01-21 | 福州大学 | Microflow control chip electrochemical detection device capable of accurately controlling electrode distance |
| CN103501907A (en) * | 2011-01-10 | 2014-01-08 | 伊鲁米那股份有限公司 | Systems, methods, and apparatuses to image a sample for biological or chemical analysis |
| WO2017096296A1 (en) * | 2015-12-04 | 2017-06-08 | President And Fellows Of Harvard College | Clamping system for a microfluidic assembly |
| CN205710714U (en) * | 2016-06-23 | 2016-11-23 | 北京普若博升生物科技有限公司 | A kind of nano-pore chip fixture |
| CN206383074U (en) * | 2017-01-04 | 2017-08-08 | 原子高科医药有限公司 | A kind of adjustable grip device of clamping force |
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| Publication number | Publication date |
|---|---|
| CN109465047A (en) | 2019-03-15 |
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