CN109464302B - Composition containing dipotassium glycyrrhizinate - Google Patents
Composition containing dipotassium glycyrrhizinate Download PDFInfo
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- CN109464302B CN109464302B CN201811637659.2A CN201811637659A CN109464302B CN 109464302 B CN109464302 B CN 109464302B CN 201811637659 A CN201811637659 A CN 201811637659A CN 109464302 B CN109464302 B CN 109464302B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/48—Thickener, Thickening system
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Abstract
The invention discloses a composition containing dipotassium glycyrrhizinate, wherein the pH value of the composition is 3.0-4.5, the viscosity of the composition is more than 1000mPa.s, the composition also comprises a synergist, wherein the synergist is selected from the following components: polyol synergists and polyethylene glycol synergists. Personal care products comprising the composition are also disclosed.
Description
Technical Field
The invention relates to a composition containing dipotassium glycyrrhizinate, in particular to a composition containing dipotassium glycyrrhizinate with viscosity acceptable in the field of cosmetics.
Background
The liquorice is a common medicinal material and is widely used in cosmetic formulations for whitening, anti-aging, anti-inflammation, anti-allergy and the like. Dipotassium glycyrrhizinate is one of the most common active substances extracted from liquorice and has excellent whitening, anti-inflammatory, antiallergic, moisturizing and other efficacies (see [1] kingdom, Zhouyang, Liuhai Peak, and the like, active ingredients of liquorice and application thereof in cosmetics [ J ]. daily chemical industry, 2004,34 (4): 249 and 251; [2] application of Chenbaohua, Gaoying, Yuanhua, dipotassium glycyrrhizinate and stearyl glycyrrhetinate in cosmetics [ J ]. Chinese cosmetics 2014, (7): 78-81). In the pharmaceutical industry, dipotassium glycyrrhizinate can be used for eye drops and ointments for stomatitis; in the cosmetic industry, dipotassium glycyrrhizinate can be used for skin care products and face cream; in the daily chemical industry, dipotassium glycyrrhizinate can be used for toothpaste; in the food industry, dipotassium glycyrrhizinate can be used as a potassium supplement agent, a sweetening agent, an antistaling agent and a flavoring agent for sports drinks. However, dipotassium glycyrrhizinate, which is an ionic compound, has a viscosity reducing effect on a thickening system commonly used in compositions (see [2] Chenbaohua, Gaoyinghua, Yuanhua, application of dipotassium glycyrrhizinate and stearyl alcohol glycyrrhetinate in cosmetics [ J ]. China cosmetics, 2014, (7): 78-81). Therefore, it has been a difficult problem in the industry to solve the problem of viscosity in the composition containing dipotassium glycyrrhizinate. Especially for the cosmetic field, the viscosity of the product is of vital importance for the consumer experience.
In order to increase the viscosity of products comprising dipotassium glycyrrhizinate, attempts were made to lower the pH of the product by adding an acid. However, it has been found that even when the pH of a solution of dipotassium glycyrrhizinate is lowered to about 4.5, the viscosity is still about 500mpa.s, and the general demand in the field of cosmetics cannot be satisfied.
Therefore, there is still a need in the art for a method of increasing the viscosity of a product comprising dipotassium glycyrrhizinate, which is capable of effectively increasing the viscosity of the product, while these synergists added to the product themselves have the efficacy of moisturizing (see [3] Liu Pu, commonly used humectant moisture absorption and moisturizing performance evaluation [ J ] Shanghai medicine, 2018,39(11):60-63), thereby obtaining a product more attractive to consumers.
Disclosure of Invention
In one aspect, the present invention provides a composition comprising dipotassium glycyrrhizinate, said composition having a pH of from 3.0 to 4.5, said composition having a viscosity of greater than 1000mpa.s, said composition further comprising a potentiator, wherein said potentiator is selected from: polyol synergists, polyethylene glycol synergists, or combinations thereof.
In a preferred embodiment, the polyol synergist used in the composition of the present invention is a polyol having a carbon number of less than or equal to 5.
In a more preferred embodiment, the polyol synergist used in the composition of the invention is selected from: glycerin, propylene glycol, butylene glycol, or combinations thereof.
In a preferred embodiment, the polyethylene glycol based synergist used in the composition of the present invention is polyethylene glycol having a weight average molecular weight of 200 to 2000.
In a more preferred embodiment, the polyethylene glycol synergist used in the composition of the invention is selected from: PEG-8, PEG-12, PEG-32 or combinations thereof.
In a preferred embodiment, the pH of the composition of the invention is between 3.5 and 4.5.
In a preferred embodiment, the composition comprises from 0.01% to 5.0% dipotassium glycyrrhizinate by total weight of the composition.
In a preferred embodiment, the composition comprises from 5% to 20% of the synergist, based on the total weight of the composition.
In another aspect, the present invention is also directed to a personal care product comprising the composition of the present invention.
In a preferred embodiment, the personal care product is selected from the following forms: lotions, essences, lotions, creams and gels.
Detailed Description
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, the preferred methods and materials are described herein. For the purposes of the present invention, the following terms are defined below.
The term "about" as used herein refers to an amount, level, value, dimension, size, or amount that differs by up to 30%, 20%, or 10% as compared to the amount, level, value, dimension, size, or amount of a reference. The percentages used herein are by weight unless otherwise indicated.
Throughout the specification and claims, unless the context requires otherwise, the word "comprise", and variations such as "comprises" and "comprising", will be understood to imply the inclusion of a stated integer or step or group of integers or steps but not the exclusion of any other integer or step or group of integers or steps.
In the present description and claims, unless otherwise specified, the contents of the components in the mixture refer to their weight percentages.
The present invention is based on the following unexpected findings: the addition of some synergists (e.g., polyol-based synergists and/or polyethylene glycol-based synergists) to the composition comprising dipotassium glycyrrhizinate can effectively increase the viscosity of the composition. Moreover, the added synergists (such as polyol synergists and/or polyethylene glycol synergists) have excellent moisturizing capability per se, and are beneficial to improving the moisturizing effect of the composition.
The application innovatively finds that certain hydroxyl-containing polyol substances and certain substances containing polyethylene glycol structures can improve the thickening capacity of dipotassium glycyrrhizinate. On the one hand, higher viscosities of aqueous solutions of dipotassium glycyrrhizinate can be achieved by using these synergists. On the other hand, the consumption of the dipotassium glycyrrhizinate can be reduced, so that the cost is saved. In addition, the hydroxyl-containing polyol substance and the substance containing the polyethylene glycol structure have excellent moisturizing capability, and are favorable for improving the combined moisturizing efficacy.
The invention provides a composition containing dipotassium glycyrrhizinate, which has viscosity of more than 1000mPa.s according to the operation requirement of a viscometer BROOKFIELD DV III ULTRA. In some preferred embodiments, the composition has a viscosity greater than 1500mpa.s, as determined by the operating requirements of the viscometer brokfield DV iii ULTRA. In some preferred embodiments, the composition has a viscosity of greater than 2000mpa.s, as determined by the operating requirements of the viscometer brokfield DV iii ULTRA. In some preferred embodiments, the composition has a viscosity greater than 5000mpa.s, as measured by the operating requirements of the viscometer brokfield DV iii ULTRA. In some preferred embodiments, the composition has a viscosity greater than 10000mpa.s, as measured by the operating requirements of the viscometer brokfield DV iii ULTRA.
In some embodiments, the pH of the composition of the present invention comprising dipotassium glycyrrhizinate ranges from 3.0 to 4.5. In a preferred embodiment, the pH of the composition of the present invention comprising dipotassium glycyrrhizinate is in the range of 3.5 to 4.5. In a more preferred embodiment, the composition of the present invention comprising dipotassium glycyrrhizinate has a pH of 4.
In some embodiments, the composition of the present invention comprising dipotassium glycyrrhizinate comprises a potentiator selected from the group consisting of: polyol synergists, polyethylene glycol synergists, or combinations thereof.
In some preferred embodiments, the polyol synergist included in the dipotassium glycyrrhizinate-containing composition of the present invention is a polyol having a carbon number of less than or equal to 4. In a particular embodiment, the polyol synergist is selected from: glycerin, propylene glycol, butylene glycol, or combinations thereof. For example, in one particular embodiment, the polyol synergist in the composition comprising dipotassium glycyrrhizinate is 1, 2-propanediol. For example, in one particular embodiment, the polyol synergist in the composition comprising dipotassium glycyrrhizinate is 1, 3-propanediol. For example, in one particular embodiment, the polyol synergist in the composition comprising dipotassium glycyrrhizinate is 1, 3-butanediol.
In some preferred embodiments, the polyethylene glycol synergist included in the dipotassium glycyrrhizinate-containing composition of the present invention is polyethylene glycol having an average molecular weight of 200 to 2000. In a more preferred embodiment, the polyethylene glycol based synergist is polyethylene glycol having an average molecular weight of 200 to 1000. For example, in some embodiments, the polyethylene glycol based synergist is a polyethylene glycol having an average molecular weight of 400 to 1000. In some embodiments, the polyethylene glycol synergist is a polyethylene glycol having an average molecular weight of 200 to 500. In a specific embodiment, the polyethylene glycol synergist is selected from: PEG-8, PEG-12, PEG-32 or combinations thereof. In a preferred embodiment, the molecular weight of the polyethylene glycol refers to the weight average molecular weight.
In some embodiments, the concentration of dipotassium glycyrrhizinate in the compositions of the present invention comprising dipotassium glycyrrhizinate ranges from 0.01% to 5.0% by weight. In a preferred embodiment, the concentration of dipotassium glycyrrhizinate in the composition of the present invention comprising dipotassium glycyrrhizinate is from 0.1% to 1% by weight. In a preferred embodiment, the concentration of dipotassium glycyrrhizinate in the composition of the present invention comprising dipotassium glycyrrhizinate is from 0.5% to 1% by weight.
In some embodiments, the concentration of the potentiator in the compositions of the present invention comprising dipotassium glycyrrhizinate ranges from 5-20% by weight. In a preferred embodiment, the concentration of dipotassium glycyrrhizinate in the composition of the present invention comprising dipotassium glycyrrhizinate is 10-20% by weight.
The present invention also relates to personal care products comprising said composition comprising dipotassium glycyrrhizinate. In a preferred embodiment, the personal care product may be in the form of: a lotion having a viscosity of less than 2000mpa.s, preferably a lotion having a viscosity of less than 1000 mpa.s; an essence having a viscosity of less than 4000mpa.s, preferably less than 3000 mpa.s; emulsions having a viscosity in the range 3000-30000mPa.s, preferably in the range 5000-20000 mPa.s; a cream having a viscosity range of 20000-; a gel having a viscosity of 20000-. Preferred personal care products are lotions, essences and gels.
Detailed Description
The technical aspects of the present invention will be described in detail below with reference to preferred embodiments, but the scope of the present invention is not limited to these embodiments, and the technical aspects of the present invention are intended to be described and not limited. Test methods in which specific conditions are not specified in the following examples are generally carried out under conventional conditions or under conditions recommended by the manufacturer. All percentages and parts are by weight unless otherwise indicated.
The experimental materials used in the examples of the present invention are as follows:
1. dipotassium glycyrrhizinate (trade name: dipotassium glycyrrhizinate); from Wanshan Co Ltd
2. Citric acid (trade name: citric acid monohydrate); purchased from Hunan Dongting citrate chemistry, Inc
3. Deionized water
4. Tromethamine (trade name: TRIS AMINO)TMULTRA PC), available from dow chemical co
5. Glycerol, purchased from Turkey palm (Zhang hong Kong) Co Ltd
6. Propylene glycol, 1, 2-propanediol, available from Dow chemical Co., Ltd
1, 3-propanediol, trade name: zemea, available from Shanghai Korea Silk Ltd
8.1, 3-butanediol, available from Clam Ltd
1, 2-pentanediol, trade name: HYDROLITE 5, available from DEZYM CO
10.1, 2-hexanediol, available from Dengyxin Co., Ltd
PEG-8, trade name: polyglykol 400, available from Klien, Inc
PEG-12 from Sooka, Inc
PEG-32, available under the trade name CARBOWAX (TM) POLYETHYLENEGGLYCOL 1450Flake, available from Dow chemical Co., Ltd
The experimental apparatus used in the examples of the present invention is as follows:
1. fixed agitator IKA RW20
2. HWS 28 model of constant temperature water bath Shanghai-Hengchun scientific instruments Co., Ltd
3. Weighing balance METTLER TOLEDO PL602-S
4. Viscometer BROOKFIELD DV III ULTRA
pH meter METTLER TOLEDO 470K
6. Homogenizer SILVERSON L5T
Example 1: preparation of composition containing dipotassium glycyrrhizinate
Accurately weighing 1.0g of dipotassium glycyrrhizinate, adding the dipotassium glycyrrhizinate into 70g of deionized water, and uniformly stirring and dispersing to obtain a dipotassium glycyrrhizinate solution for later use;
adjusting the pH value of the dipotassium glycyrrhizinate solution to 4.5 by using citric acid, and finally complementing the weight of the system to 100g by using deionized water for later use.
Example 2: preparation of composition containing dipotassium glycyrrhizinate
Accurately weighing 1.0g of dipotassium glycyrrhizinate, adding the dipotassium glycyrrhizinate into 70g of deionized water, and uniformly stirring and dispersing to obtain a dipotassium glycyrrhizinate solution for later use;
adjusting pH of the dipotassium glycyrrhizinate solution to 4.5 with citric acid, adding 5g of glycerol, and finally supplementing 100g of the system weight with deionized water for later use.
Example 3: preparation of composition containing dipotassium glycyrrhizinate
Accurately weighing 1.0g of dipotassium glycyrrhizinate, adding the dipotassium glycyrrhizinate into 70g of deionized water, and uniformly stirring and dispersing to obtain a dipotassium glycyrrhizinate solution for later use;
adjusting pH of the dipotassium glycyrrhizinate solution to 4.5 by using citric acid, then adding 10g of glycerol, and finally complementing the weight of the system to 100g by using deionized water for later use.
Example 4: preparation of composition containing dipotassium glycyrrhizinate
Accurately weighing 1.0g of dipotassium glycyrrhizinate, adding the dipotassium glycyrrhizinate into 70g of deionized water, and uniformly stirring and dispersing to obtain a dipotassium glycyrrhizinate solution for later use;
adjusting pH of the dipotassium glycyrrhizinate solution to 4.5 with citric acid, adding 20g of glycerol, and finally supplementing 100g of the system weight with deionized water for later use.
Example 5: preparation of composition containing dipotassium glycyrrhizinate
Accurately weighing 1.0g of dipotassium glycyrrhizinate, adding the dipotassium glycyrrhizinate into 70g of deionized water, and uniformly stirring and dispersing to obtain a dipotassium glycyrrhizinate solution for later use;
adjusting pH of the dipotassium glycyrrhizinate solution to 4.5 with citric acid, adding 5g propylene glycol, and finally adding deionized water to make up 100g of the weight of the system for later use.
Example 6: preparation of composition containing dipotassium glycyrrhizinate
Accurately weighing 1.0g of dipotassium glycyrrhizinate, adding the dipotassium glycyrrhizinate into 70g of deionized water, and uniformly stirring and dispersing to obtain a dipotassium glycyrrhizinate solution for later use;
adjusting pH of the dipotassium glycyrrhizinate solution to 4.5 by using citric acid, then adding 10g of propylene glycol, and finally complementing the weight of the system to 100g by using deionized water for later use.
Example 7: preparation of composition containing dipotassium glycyrrhizinate
Accurately weighing 1.0g of dipotassium glycyrrhizinate, adding the dipotassium glycyrrhizinate into 70g of deionized water, and uniformly stirring and dispersing to obtain a dipotassium glycyrrhizinate solution for later use;
adjusting pH of the dipotassium glycyrrhizinate solution to 4.5 with citric acid, adding 20g propylene glycol, and finally adding deionized water to make up 100g of the weight of the system for later use.
Example 8: preparation of composition containing dipotassium glycyrrhizinate
Accurately weighing 1.0g of dipotassium glycyrrhizinate, adding the dipotassium glycyrrhizinate into 70g of deionized water, and uniformly stirring and dispersing to obtain a dipotassium glycyrrhizinate solution for later use;
adjusting pH of the dipotassium glycyrrhizinate solution to 4.5 with citric acid, adding 5g of 1, 3-propylene glycol, and finally adding deionized water to make up 100g of the weight of the system for later use.
Example 9: preparation of composition containing dipotassium glycyrrhizinate
Accurately weighing 1.0g of dipotassium glycyrrhizinate, adding the dipotassium glycyrrhizinate into 70g of deionized water, and uniformly stirring and dispersing to obtain a dipotassium glycyrrhizinate solution for later use;
adjusting pH of the dipotassium glycyrrhizinate solution to 4.5 by using citric acid, then adding 10g of 1, 3-propylene glycol, and finally complementing the weight of the system to 100g by using deionized water for later use.
Example 10: preparation of composition containing dipotassium glycyrrhizinate
Accurately weighing 1.0g of dipotassium glycyrrhizinate, adding the dipotassium glycyrrhizinate into 70g of deionized water, and uniformly stirring and dispersing to obtain a dipotassium glycyrrhizinate solution for later use;
adjusting pH of the dipotassium glycyrrhizinate solution to 4.5 with citric acid, adding 20g of 1, 3-propylene glycol, and finally supplementing 100g of the system weight with deionized water for later use.
Example 11: preparation of composition containing dipotassium glycyrrhizinate
Accurately weighing 1.0g of dipotassium glycyrrhizinate, adding the dipotassium glycyrrhizinate into 70g of deionized water, and uniformly stirring and dispersing to obtain a dipotassium glycyrrhizinate solution for later use;
adjusting pH of the dipotassium glycyrrhizinate solution to 4.5 with citric acid, adding 5g of 1, 3-butanediol, and finally supplementing 100g of the system weight with deionized water for later use.
Example 12: preparation of composition containing dipotassium glycyrrhizinate
Accurately weighing 1.0g of dipotassium glycyrrhizinate, adding the dipotassium glycyrrhizinate into 70g of deionized water, and uniformly stirring and dispersing to obtain a dipotassium glycyrrhizinate solution for later use;
adjusting pH of the dipotassium glycyrrhizinate solution to 4.5 by using citric acid, then adding 10g of 1, 3-butanediol, and finally complementing the weight of the system to 100g by using deionized water for later use.
Example 13: preparation of composition containing dipotassium glycyrrhizinate
Accurately weighing 1.0g of dipotassium glycyrrhizinate, adding the dipotassium glycyrrhizinate into 70g of deionized water, and uniformly stirring and dispersing to obtain a dipotassium glycyrrhizinate solution for later use;
adjusting pH of the dipotassium glycyrrhizinate solution to 4.5 with citric acid, adding 20g of 1, 3-butanediol, and finally supplementing 100g of the system weight with deionized water for later use.
Example 14: preparation of composition containing dipotassium glycyrrhizinate
Accurately weighing 1.0g of dipotassium glycyrrhizinate, adding the dipotassium glycyrrhizinate into 70g of deionized water, and uniformly stirring and dispersing to obtain a dipotassium glycyrrhizinate solution for later use;
adjusting pH of the dipotassium glycyrrhizinate solution to 4.5 with citric acid, adding 5g of PEG-8, and finally adding deionized water to make up 100g of the weight of the system for later use.
Example 15: preparation of composition containing dipotassium glycyrrhizinate
Accurately weighing 1.0g of dipotassium glycyrrhizinate, adding the dipotassium glycyrrhizinate into 70g of deionized water, and uniformly stirring and dispersing to obtain a dipotassium glycyrrhizinate solution for later use;
adjusting pH of the dipotassium glycyrrhizinate solution to 4.5 with citric acid, adding 10g of PEG-8, and finally supplementing 100g of the system weight with deionized water for later use.
Example 16: preparation of composition containing dipotassium glycyrrhizinate
Accurately weighing 1.0g of dipotassium glycyrrhizinate, adding the dipotassium glycyrrhizinate into 70g of deionized water, and uniformly stirring and dispersing to obtain a dipotassium glycyrrhizinate solution for later use;
adjusting pH of the dipotassium glycyrrhizinate solution to 4.5 with citric acid, adding 20g of PEG-8, and finally supplementing 100g of the system weight with deionized water for later use.
Example 17: preparation of composition containing dipotassium glycyrrhizinate
Accurately weighing 1.0g of dipotassium glycyrrhizinate, adding the dipotassium glycyrrhizinate into 70g of deionized water, and uniformly stirring and dispersing to obtain a dipotassium glycyrrhizinate solution for later use;
adjusting pH of the dipotassium glycyrrhizinate solution to 4.5 with citric acid, adding 5g of PEG-12, and finally adding deionized water to make up 100g of the weight of the system for later use.
Example 18: preparation of composition containing dipotassium glycyrrhizinate
Accurately weighing 1.0g of dipotassium glycyrrhizinate, adding the dipotassium glycyrrhizinate into 70g of deionized water, and uniformly stirring and dispersing to obtain a dipotassium glycyrrhizinate solution for later use;
adjusting pH of the dipotassium glycyrrhizinate solution to 4.5 with citric acid, adding 10g of PEG-12, and finally adding deionized water to make up 100g of the weight of the system for later use.
Example 19: preparation of composition containing dipotassium glycyrrhizinate
Accurately weighing 1.0g of dipotassium glycyrrhizinate, adding the dipotassium glycyrrhizinate into 70g of deionized water, and uniformly stirring and dispersing to obtain a dipotassium glycyrrhizinate solution for later use;
adjusting pH of the dipotassium glycyrrhizinate solution to 4.5 with citric acid, adding 15g of PEG-12, and finally adding deionized water to make up 100g of the weight of the system for later use.
Example 20: preparation of composition containing dipotassium glycyrrhizinate
Accurately weighing 1.0g of dipotassium glycyrrhizinate, adding the dipotassium glycyrrhizinate into 70g of deionized water, and uniformly stirring and dispersing to obtain a dipotassium glycyrrhizinate solution for later use;
adjusting pH of the dipotassium glycyrrhizinate solution to 4.5 with citric acid, adding 5g of PEG-32, and finally adding deionized water to make up 100g of the weight of the system for later use.
Example 21: preparation of composition containing dipotassium glycyrrhizinate
Accurately weighing 1.0g of dipotassium glycyrrhizinate, adding the dipotassium glycyrrhizinate into 70g of deionized water, and uniformly stirring and dispersing to obtain a dipotassium glycyrrhizinate solution for later use;
adjusting pH of the dipotassium glycyrrhizinate solution to 4.5 by using citric acid, then adding 10g of PEG-32, and finally complementing the weight of the system to 100g by using deionized water for later use.
Example 22: preparation of composition containing dipotassium glycyrrhizinate
Accurately weighing 1.0g of dipotassium glycyrrhizinate, adding the dipotassium glycyrrhizinate into 70g of deionized water, and uniformly stirring and dispersing to obtain a dipotassium glycyrrhizinate solution for later use;
adjusting pH of the dipotassium glycyrrhizinate solution to 4.5 by using citric acid, then adding 15g of PEG-32, and finally complementing the weight of the system to 100g by using deionized water for later use.
Test example 1: viscosity measurement
Viscosity test samples: examples 1-23 the resulting samples were prepared.
Procedure and conditions for viscosity testing:
1. placing the sample in a proper beaker, and standing for half an hour at 25 ℃;
2. selecting a proper rotor and adjusting the setting parameters of the control panel;
3. installing a rotor, and enabling the rotor to sink over the sample to a designated scale position;
4. starting a viscometer switch and recording data;
5. in the examples 1 to 17, the detection conditions are 25 ℃, 03 rotor and 6 r/min of rotating speed;
the test conditions of examples 18 to 23 were 25 ℃ at a rotor number 04 and 6 rpm.
Example 23: preparation of composition containing dipotassium glycyrrhizinate
Accurately weighing 1.0g of dipotassium glycyrrhizinate, adding the dipotassium glycyrrhizinate into 70g of deionized water, and uniformly stirring and dispersing to obtain a dipotassium glycyrrhizinate solution for later use;
adjusting pH of the dipotassium glycyrrhizinate solution to 3.5 with citric acid, adding 20g of 1, 3-propylene glycol, and finally supplementing 100g of the system weight with deionized water for later use.
Example 24: preparation of composition containing dipotassium glycyrrhizinate
Accurately weighing 1.0g of dipotassium glycyrrhizinate, adding the dipotassium glycyrrhizinate into 70g of deionized water, and uniformly stirring and dispersing to obtain a dipotassium glycyrrhizinate solution for later use;
adjusting pH of the dipotassium glycyrrhizinate solution to 4.0 with citric acid, adding 20g of 1, 3-propylene glycol, and finally supplementing 100g of the system weight with deionized water for later use.
Test example 2: viscosity measurement
Viscosity test samples: examples 18-19 the resulting samples were prepared.
Procedure and conditions for viscosity testing:
1. placing the sample in a proper beaker, and standing for half an hour at 25 ℃;
2. selecting a proper rotor and adjusting the setting parameters of the control panel;
3. installing a rotor, and enabling the rotor to submerge the sample to a specified scale position;
4. starting a viscometer switch and recording data;
5. in examples 24 to 25, the test conditions were 25 ℃ at a rotor number 03 and 6 rpm.
The samples were subjected to viscosity measurements according to the operating requirements of the viscometer BROOKFIELD DV III ULTRA, the results of which are shown in Table 2.
Table 2: viscosity change of dipotassium glycyrrhizinate composition with different pH values after adding synergist
It can be seen from the data of the examples that under the action of the synergist, the dipotassium glycyrrhizinate can still exert the thickening effect at a lower pH (for example, in the range of pH 3.5-4.5), and the thickening efficiency is higher.
Comparative example 1:
accurately weighing 20g of glycerol, adding the glycerol into 80g of deionized water, and uniformly stirring to obtain a glycerol aqueous solution for later use.
Comparative example 2:
accurately weighing 20g of propylene glycol, adding the propylene glycol into 80g of deionized water, and uniformly stirring to obtain a glycerol aqueous solution for later use.
Comparative example 3:
accurately weighing 20g of 1, 3-propylene glycol, adding into 80g of deionized water, and uniformly stirring to obtain a glycerol aqueous solution for later use.
Comparative example 4:
accurately weighing 20g of 1, 3-butanediol, adding into 80g of deionized water, and uniformly stirring to obtain a glycerol aqueous solution for later use.
Comparative example 5:
accurately weighing 20g of PEG-8, adding into 80g of deionized water, and uniformly stirring to obtain a glycerol aqueous solution for later use.
Test example 3: viscosity measurement
Viscosity test samples: the obtained samples were prepared in comparative examples 1 to 5.
Procedure and conditions for viscosity testing:
1. placing the sample in a proper beaker, and standing for half an hour at 25 ℃;
2. selecting a proper rotor and adjusting the setting parameters of the control panel;
3. installing a rotor, and enabling the rotor to submerge the sample to a specified scale position;
4. starting a viscometer switch and recording data;
5. the comparative examples 1 to 5 were conducted under the conditions of 25 ℃ at a rotor number 03 and at a rotational speed of 6 rpm.
The samples were subjected to viscosity measurements according to the operating requirements of the viscometer BROOKFIELD DV III ULTRA, the results of which are shown in Table 3.
Table 3: viscosity change of compositions of different synergists and water
The comparative data show that the aqueous solutions of various synergistic materials do not have viscosity, and the comparison of the data in Table 1 shows that the synergist does not increase the viscosity of the aqueous solution of licorice root by the inherent viscosity, and the synergist helps to increase the viscosity of the aqueous solution of licorice root.
Comparative example 6
Accurately weighing 1.0g of dipotassium glycyrrhizinate, adding the dipotassium glycyrrhizinate into 70g of deionized water, and uniformly stirring and dispersing to obtain a dipotassium glycyrrhizinate solution for later use;
adjusting pH of the dipotassium glycyrrhizinate solution to 4.5 by using citric acid, then adding 10g of 1, 2-pentanediol, and finally complementing the weight of the system to 100g by using deionized water for later use.
Comparative example 7
Accurately weighing 1.0g of dipotassium glycyrrhizinate, adding the dipotassium glycyrrhizinate into 70g of deionized water, and uniformly stirring and dispersing to obtain a dipotassium glycyrrhizinate solution for later use;
adjusting pH of the dipotassium glycyrrhizinate solution to 4.5 by using citric acid, then adding 20g of 1, 2-pentanediol, and finally complementing the weight of the system to 100g by using deionized water for later use.
Comparative example 8
Accurately weighing 1.0g of dipotassium glycyrrhizinate, adding the dipotassium glycyrrhizinate into 70g of deionized water, and uniformly stirring and dispersing to obtain a dipotassium glycyrrhizinate solution for later use;
adjusting pH of the dipotassium glycyrrhizinate solution to 4.5 by using citric acid, then adding 5g of 1, 2-hexanediol, and finally complementing the weight of the system to 100g by using deionized water for later use.
Comparative example 9
Accurately weighing 1.0g of dipotassium glycyrrhizinate, adding the dipotassium glycyrrhizinate into 70g of deionized water, and uniformly stirring and dispersing to obtain a dipotassium glycyrrhizinate solution for later use;
adjusting pH of the dipotassium glycyrrhizinate solution to 4.5 by using citric acid, then adding 10g of 1, 2-hexanediol, and finally complementing the weight of the system to 100g by using deionized water for later use.
Comparative example 10
Accurately weighing 1.0g of dipotassium glycyrrhizinate, adding the dipotassium glycyrrhizinate into 70g of deionized water, and uniformly stirring and dispersing to obtain a dipotassium glycyrrhizinate solution for later use;
adjusting pH of the dipotassium glycyrrhizinate solution to 4.5 by using citric acid, then adding 20g of 1, 2-hexanediol, and finally complementing the weight of the system to 100g by using deionized water for later use.
Test example 4: viscosity measurement
Viscosity test samples: the obtained samples were prepared in comparative examples 6 to 10.
Procedure and conditions for viscosity testing:
1. placing the sample in a proper beaker, and standing for half an hour at 25 ℃;
2. selecting a proper rotor and adjusting the setting parameters of the control panel;
3. installing a rotor, and enabling the rotor to submerge the sample to a specified scale position;
4. starting a viscometer switch and recording data;
5. in comparative examples 6 to 10, the test conditions were 25 ℃ at a rotor number 03 and 6 rpm.
The samples were subjected to viscosity measurements according to the operating requirements of the viscometer BROOKFIELD DV III ULTRA, the results of which are shown in Table 4.
Table 4: viscosity change of composition of different polyols and water
As seen from the comparative example, high concentrations of 1, 2-pentanediol and 1, 2-hexanediol reduce the viscosity of the aqueous solution of dipotassium glycyrrhizinate. As can be seen from the data of comparative example 18, not all substances are able to raise the viscosity of the aqueous solution of dipotassium glycyrrhizinate.
Application example
The composition can be used as an intermediate raw material of a formula and applied to preparation of finished products of dosage forms such as face cream, lotion, gel, lotion, essence, facial mask, eye cream, aerosol (cleaning foam), spray, shower gel, facial cleanser and the like, and the specific application examples are as follows:
application example 1: preparation of face cream
Application example 2: preparation of the emulsion
Application example 3: preparation of jelly
Application example 4: preparation of astringent
Application example 5: preparation of essence
Application example 6: preparation of facial mask
Application example 7: preparation of eye cream
Application example 8: preparation of an aerosol (cleaning foam)
Application example 9: preparation of the spray
Application example 10: preparation of shower gel
Application example 11: preparation of facial cleanser
Claims (6)
1. Use of a potentiator to increase the viscosity of a composition comprising dipotassium glycyrrhizinate, said composition having a pH of from 3.5 to 4.5, said composition having a viscosity of greater than 1000mpa.s as measured by the operating requirements of the viscometer brokfield DV iii ULTRA, wherein said potentiator is selected from: a polyol synergist, a polyethylene glycol synergist or a combination thereof, wherein the polyol synergist is a polyol having a carbon number of 4 or less, the polyethylene glycol synergist is a polyethylene glycol having a weight average molecular weight of 200 to 2000,
the composition comprises from 5% to 20% of the synergist by total weight of the composition.
2. Use according to claim 1, wherein the polyol synergist is selected from: glycerin, propylene glycol, butylene glycol, or combinations thereof.
3. Use according to claim 1, wherein the polyethylene glycol synergist is selected from: PEG-8, PEG-12, PEG-32 or combinations thereof.
4. The use according to claim 1, wherein said composition comprises from 0.01% to 5.0% dipotassium glycyrrhizinate, based on the total weight of said composition.
5. Use of a potentiator to increase the viscosity of a personal care product comprising dipotassium glycyrrhizinate, wherein said personal care product has a pH of from 3.5 to 4.5 and a viscosity of greater than 1000mPa.s as measured according to the operating requirements of the viscometer BROOKFIELD DV III ULTRA,
wherein the synergist is selected from: a polyol synergist, a polyethylene glycol synergist or a combination thereof, wherein the polyol synergist is a polyol having a carbon number of 4 or less, wherein the polyethylene glycol synergist is a polyethylene glycol having a weight average molecular weight of 200 to 2000,
wherein the personal care product comprises from 5% to 20% of the synergist based on the total weight of the personal care product.
6. The use according to claim 5, wherein the personal care product is selected from the following forms: lotions, essences, lotions, creams and gels.
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