CN109432299A - 一种竹鼠油创口膏及其制备方法 - Google Patents
一种竹鼠油创口膏及其制备方法 Download PDFInfo
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- CN109432299A CN109432299A CN201811545571.8A CN201811545571A CN109432299A CN 109432299 A CN109432299 A CN 109432299A CN 201811545571 A CN201811545571 A CN 201811545571A CN 109432299 A CN109432299 A CN 109432299A
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Abstract
本发明公开一种竹鼠油创口膏及其制备方法,属于中医药技术领域。该竹鼠油创口膏包括竹鼠油、至少一种治创伤中草药、至少一种乳化剂和至少一种粘合剂。其制备方法是将部分治创伤中草药磨粉,过200目筛,将剩余治创伤中草药经过两次煎煮后,混合煎液,再加入竹鼠油和乳化剂混合后,充分乳化,将粉和乳化液充分混合后,再加入粘合剂搅拌均匀成膏即得本发明配方合理,制备方法简单,安全无毒副作用,无药物残留,无耐药性,生物利用度高,对创口的止血、愈合和无痕有显著效果。
Description
技术领域
本发明涉及中医药技术领域,具体涉及一种竹鼠油创口膏及其制备方法。
背景技术
创口是皮肤及其深部组织连续性中断所形成的裂口。各种机械外力都可形成,其大小和形状与外力性质、损伤部位和作用方向有关。创口极为常见,不仅可以大量发生在战争时期,也可发生在和平时期,包括摔伤、割伤、刺伤等。由于工业、农业、交通业及体育事业的高速发展,各种事故所造成的创伤日趋增多。创口不仅发生率高,而且程度差别很大,伤情可以严重而复杂,甚至危及伤员的生命。
中草药是我国最为传统且天然存在的药材,而且资源来源极其丰富、价格相对低廉,含有多种天然的化学成分和营养成分,例如鞣质、皂甙、生物碱、有机酸、维生素、矿物质、微量元素等,这些成分除了具有抗菌、抗病毒、抗炎、解毒、消肿、止痒、生肌、活血、祛风、润肤的作用,还能够提高免疫机能、提高生产性能、补充营养等,中草药制剂在治疗创伤方面具有一定的优势。
另一方面,现有技术中有各种各样的创口贴,在使用过程中仍然存在一定的缺陷,特别是有摔伤中的应用:一是需要清理创口,在野外很难有有效的清洁手段;二是在南方天气炎热,创口被贴住后很难愈合。因此,研发出效果好、无副作用的创口膏仍然是人们的期望。
发明内容
本发明的目的是解决现有技术中存在的问题,提供一种配方合理、疗效明显、制备方法简单和无副作用,并且能有效治愈创伤的中草药制剂。
本发明的原料均来自中草药,科学配制成一种竹鼠油创口膏中药制剂,此中草药制剂具有抗菌、消炎、泻火、解毒、排脓、消肿、止痒、生肌、活血、祛风、润肤和提高机体免疫力等功效,特别是可以清洁伤口异物,适用于各种原因引起的外创口的治疗,无毒副作用,能消除疤痕,达到美容之功效。为实现本发明目的,所采用的技术方案如下:
一种竹鼠油创口膏,包括以下原料:
1)竹鼠油;
2)至少一种治创伤中草药;
3)至少一种乳化剂;
4)至少一种粘合剂。
优选地,所述治创伤中草药为金狗毛、见血清、一点血、九死还魂草、菊叶三七、白芨、白花蛇舌草、半枝莲的一种或多种。
优选地,所述乳化剂为卵磷脂。
优选地,所述粘合剂为纤维素胶优选地,所述竹鼠油占所有原料的质量百分比不低于50%。
优选地,所述竹鼠油占所有原料的质量百分比不低于60%。
优选地,所述乳化剂占所有原料的质量百分比不低于2%。
优选地,所述粘合剂占所有原料的质量百分比不低于1%。
本发明还提供一种如以上所述竹鼠油创口膏的制备方法,包括以下步骤:
(1)称取各原料;
(2)将部分治创伤中草药分别磨成粉,过200目筛;
(3)把剩余治创伤中草药置于砂锅,加入饮用水,浸泡20-30分钟后,再加水没过药物,将砂锅放在炉火上煎煮,煮沸40-50分钟后,把药液倒出,获得第一次药液;
(4)在砂锅中再加入温水,进行第二次煎煮,煮沸30分钟后,倒出药液,与第一次药液混合,自然冷却后,加入竹鼠油和卵磷脂混合后,充分乳化。
(5)把药剂充分混合后,再加入粘合剂搅拌均匀成膏,即为一种竹鼠油创口膏。
另外的,本发明提供一种如以上所述一种竹鼠油创口膏在制备治疗创伤的药物中应用。
(1)金狗毛是金狗毛蕨基部的生长出的黄棕色的毛茸。金狗毛蕨是一种药用植物,根据植物地理之分布,可分为两个分布上之类型,一个是亚洲型,另一个是夏威夷型。台湾金狗毛蕨属于亚洲型。金狗毛蕨常与其它蕨类植物构成植物群落,在中国台湾中部莲花池附近有由金狗毛蕨所构成之纯林。金狗毛可用于止血。
(2)见血清,中药名。为兰科植物脉羊耳兰的全草。分布于江西、湖南、福建、台湾、广东、广西、西南地区等地。具有凉血止血,清热解毒之功效。常用于胃热吐血,肺热咯血,肠风下血,崩漏,手术出血,创伤出血,疮疡肿毒,毒蛇咬伤,跌打损伤。
(3)一点血。多年生草本,高20~30厘米。根茎短而肥厚,有环纹,断面红色,具须根。根出叶1-2片,近菱方形,长10-15厘米,宽10-12厘米,上部3~7浅裂,裂片三角形,基部偏心形,边缘有突尖细锯齿,上面绿色,具极稀疏的短刺毛,下面略带紫色;叶柄光滑,基部肥厚,长7~15厘米;托叶膜质,光滑,褐色,卵圆披针形。花6~7朵,粉红色,呈伞房状排列,花序梗粗壮,根出,长达10~20厘米;花雌雄同株;雄花花被4 片,内外各2,外花被卵圆形,内花被长椭圆形,雄蕊10~16枚,离生;雌花具花被3 片,内1外2,外花被宽卵圆形,内花被卵圆形或长椭圆形,子房呈纺锤形,3棱,花柱3 枚,离生。蒴果无翅。花期7月。生长于阴处的岩石缝及小谷底。以富含腐殖质而疏松肥沃的湿润壤土为宜。产四川。干燥根茎呈圆柱形,弯曲,外表棕黄色,具扭曲的纵皱纹及须根残痕。质脆,横断面平坦,中心有一棕红色的圆心,如一点血状。有养血补血、散瘀止痛之功效。
(4)九死还魂草,是一种多年生直立常绿草本蕨类植物,学名是卷柏,高5~15厘米,茎棕褐色,分枝丛生,扁平状,浅绿色。它具有极其顽强的抗旱本领。在天气干旱的时候,卷柏的小枝就卷起来,缩成一团,以保住体内的水分。一旦得到雨水,气温一升高,卷缩的小枝会平展开来,所以叫作“九死还魂草”。性味苦涩,平。有解毒、消肿、止血功效。治创伤,无名肿毒,蛇咬及蝎螫。
(5)菊叶三七,中药材名。本品为为菊科土三七属植物土三七,以根或全草入药。秋冬挖根,除去残茎、须根及泥土晒干。夏秋采全草,洗净,鲜用或晒干。功能主治为:散瘀止血,解毒消肿。用于吐血,衄血,尿血,便血,功能性子宫出血,产后瘀血腹痛,大骨节病;外用治跌打损伤,痈疖疮疡,蛇咬伤,外伤出血。
(6)白芨,又名连及草、甘根、白给、箬兰、朱兰。花美适合观赏之用,其球茎晒干后的名称为白及,属于中草药,其它亦有当作糊料之用途。一般品种的花色呈紫红色,所以别称紫兰;另有一个变种的花为白色,称为白花白芨(B.s.var.alba)。其它亦有黄色、粉红色、红色以及蓝色的园艺栽培种。主要花期在春季,但依各地气候之不同,晚冬至夏初都可能开花。如果种植,夏季因为叶尖容易晒焦,宜采半日照射的方式。白芨味苦、甘、涩,性寒,归肺、胃、肝经。有收敛止血,消肿生肌之功,用于内外出血诸证及痈肿、烫伤、手足皲裂、肛裂等。
(7)白花蛇舌草,别名蛇舌草、蛇舌癀、蛇针草、蛇总管、二叶葎、白花十字草、尖刀草、甲猛草、龙舌草、蛇脷草、鹤舌草,为一年生披散草本,高15-50cm。根细长,分枝,白花。茎略带方形或扁圆柱形,光滑无毛,从基部发出多分枝。花期春季。种子棕黄色,细小,且3个棱角。其成药味苦、淡,性寒。主要功效是清热解毒、消痛散结、利尿除湿。尤善治疗各种类型炎症。
(8)半枝莲,别称赶山鞭、瘦黄芩、牙刷草、田基草、水黄芩、狭叶韩信草,是马唇形科黄芩属多年生草本植物。半支莲株高可达55厘米,丛生密集,花繁艳丽,花期又长,是装饰草地、坡地和路边的优良配花,亦宜花坛边缘和花境栽植,盆栽小巧玲珑,可陈列在阳台、窗台、走廊、门前、池边和庭院等多种场所观赏。半枝莲全草入药,性寒味酸,全草含多种维生素、微量元素及氨基酸等成分。有凉血解毒,散瘀止痛,消肿和清热利湿之功效。
(9)竹鼠油,中药材名。竹鼠为啮齿目竹鼠科银星竹鼠,栖息于芒草丛下或竹林中,以竹笋、芒草为食。竹鼠肠道外附着一层透明胶冻状物质,即为竹鼠油,也称作竹鼠脂肪,可做外敷药。可治疗烫伤、烧伤、蚊虫或毒虫或毒虫叮咬引起的痒痛等症,涂抹后解毒、止痒去痛。以脂肪入药。功能主治解毒排脓,生肌止痛。
(10)纤维素胶,它的作用就像胶水一样,可以把液体、固体“粘”在一起,形成一个稳定的膏体。
(11)卵磷脂,又称为蛋黄素,被誉为与蛋白质、维生素并列的“第三营养素”,卵磷脂是人体每一个细胞不可缺少的物质,如果缺乏,就会降低皮肤细胞的再生能力,导致皮肤粗糙、有皱纹。如能适当摄取卵磷脂,皮肤再生活力得到保障,再加上卵磷脂良好的亲水性和亲油性,皮肤就有光泽。
本发明的有益效果:
1、本发明原料为“药食同源”的中草药,安全无毒副作用,无污染、无药物残留、无耐药性,生物利用度高,疗效显著。克服了目前市场上创口贴需要清洁创面和热天伤口不易愈合的缺点。
2、配方合理,制备方法简单,产品质量比较稳定,不仅止血效果好,而且具有清洁伤口、消炎、解毒、消肿、止痒和生肌的功能,而且无毒,不刺激,具有一定的去痕效果,对创伤治疗效果明显。
3、临床应用证明,对创伤有显著的疗效,并且无副作用,有效保证了人们的身体健康。
具体实施方式
下面结合实施例对本发明方案做进一步详细描述,下述说明仅是为了解释本发明,并不对其内容进行限定。下述实施例中所使用的实验方法如无特殊说明,均为常规方法,下述实施例中所使用的材料、试剂等,如无特殊说明,均可从商业途径得到。
实施例1制备一种竹鼠油创伤膏一种竹鼠油创口膏,其制备包括以下步骤:
(1)按照以下重量份称取原料:金狗毛0.1g、见血清2g、一点血2g、九死还魂草5g、菊叶三七5g、白芨5g、白花蛇舌草5g、半枝莲5g、竹鼠油50ml、纤维素胶1g和卵磷脂2g。
(2)金狗毛、见血清和一点血各组份分别磨成粉,过200目筛;
(3)把九死还魂草、菊叶三七、白芨、白花蛇舌草、半枝莲放入砂锅,加入饮用水,浸泡20-30分钟后,再加水没过药物,将砂锅放在炉火上煎煮,煮沸40-50分钟后,把药液倒出,获得第一次药液;
(4)在砂锅中再加入温水,进行第二次煎煮,煮沸30分钟后,倒出药液,与第一次药液混合,自然冷却后,加入竹鼠油和卵磷脂混合后,充分乳化。
(5)把(2)制成的粉加入到(4)中充分混合后,再加入纤维素胶搅拌均匀成膏,即为一种竹鼠油创口膏。降温至室温出料,装洁净容器。
实施例2
一种竹鼠油创口膏,其制备包括以下步骤:
(1)按照以下重量份称取原料:金狗毛0.1g、见血清3g、一点血3g、九死还魂草6g、菊叶三七6g、白芨6g、白花蛇舌草6g、半枝莲6g、竹鼠油40ml、纤维素胶1g和卵磷脂2g。
(2)金狗毛、见血清和一点血各组份分别磨成粉,过200目筛;
(3)把九死还魂草、菊叶三七、白芨、白花蛇舌草、半枝莲放入砂锅,加入饮用水,浸泡20-30分钟后,再加水没过药物,将砂锅放在炉火上煎煮,煮沸40-50分钟后,把药液倒出,获得第一次药液;
(4)在砂锅中再加入温水,进行第二次煎煮,煮沸30分钟后,倒出药液,与第一次药液混合,自然冷却后,加入竹鼠油和卵磷脂混合后,充分乳化。
(5)把(2)制成的粉加入到(4)中充分混合后,再加入纤维素胶搅拌均匀成膏,即为一种竹鼠油创伤膏。降温至室温出料,装洁净容器。
实施例3
一种竹鼠油创口膏,其制备包括以下步骤:
(1)按照以下重量份称取原料:金狗毛0.1g、见血清2g、一点血2g、九死还魂草6g、菊叶三七6g、白芨6g、白花蛇舌草6g、半枝莲6g、竹鼠油45ml、纤维素胶1g和卵磷脂2g。
(2)金狗毛、见血清和一点血各组份分别磨成粉,过200目筛;
(3)把九死还魂草、菊叶三七、白芨、白花蛇舌草、半枝莲放入砂锅,加入饮用水,浸泡20-30分钟后,再加水没过药物,将砂锅放在炉火上煎煮,煮沸40-50分钟后,把药液倒出,获得第一次药液;
(4)在砂锅中再加入温水,进行第二次煎煮,煮沸30分钟后,倒出药液,与第一次药液混合,自然冷却后,加入竹鼠油和卵磷脂混合后,充分乳化。
(5)把(2)制成的粉加入到(4)中充分混合后,再加入纤维素胶搅拌均匀成膏,即为一种竹鼠油创口膏。降温至室温出料,装洁净容器。
应用实例:为进一步考察本发明竹鼠油创口膏的药效和安全指标问题,将实施例1制备的竹鼠油创口膏进行小鼠实验,分别从皮肤急性毒性、消炎效果、镇痛效果、止血效果和灭菌效果等指标进行考核,结果如实施例4至实施例9。
实施例4
将实施例1制备的一种竹鼠油创口膏对皮肤急性毒性试验,使用步骤和效果如下:
(1)取昆明种小鼠20只,雌雄各半,每只体重约20g,随机分为2组。
(2)各小鼠背部两侧皮肤脱毛约10cm2(约为体表面积的15%),并将其中10只制作破损皮肤。一组小鼠为皮肤破损组,另一组为非破损组。在脱毛区涂一层药膏,连续观察 7天,并称重。
(3)结果。经观察两组小鼠均未发现任何异常反应,其皮肤、大便、呼吸、四肢活动、行为方式等均未发现任何异常现象;体重呈上升趋势,没有下降。该膏药对小鼠外用无任何急性毒性反应出现。
实施例5
将实施例1制备的一种竹鼠油创口膏对消炎效果试验,使用步骤和效果如下:
(1)小鼠分组。取昆明种小鼠20只,雌雄各半,随机分为2组,一组为对照组,涂生理盐水,另一组为试验组,涂竹鼠油创口膏。
(2)试验。各鼠耳背部皮肤脱毛约4cm2,在脱毛区涂约37℃温热药液0.1ml,每日2次,连续3天。末次给药后30min,以二甲苯0.1ml均匀涂于小鼠左耳壳两则致炎,右耳不涂作为对照。致炎后30分钟处死动物,用直径6mm打孔器将小鼠双耳等面积耳片割下,立即称重。
(3)结果。两耳重量差为肿胀度,与生理盐水组比较。结果表明竹鼠油创口膏能明显抑制二甲苯所致的耳壳急性炎症(见表1)。
表1.对小鼠炎症影响试验结果
组别 | n | 肿胀度(mg) | 抑制率 |
生理盐水 | 10 | 15.8±2.5 | / |
竹鼠油创口膏 | 10 | 7.2±3.3 | 54.4% |
实施例6
将实施例1制备的一种竹鼠油创口膏对镇痛效果试验,使用步骤和效果如下:
(1)选取小鼠。取昆明种雌性小鼠30只,每只体重约20g;调节超级恒温器使温度恒定在55±0.5℃,将小鼠置于瓷罐内,罐口盖用透明盖,以观察小鼠舔后足为疼痛反应指标, 记录产生反应的时间为正常痛阈值(室温约25℃)。选择痛阈值在10~30s以内的小鼠20 只作为试验小鼠,随机分为2组。
(2)痛阈值测定。试验分成2组,一组为竹鼠油创口膏组,另一组为空白对照。竹鼠油创口膏组小鼠双后足擦药膏2次,每次待所涂药液吸收后,再涂下一次,然后放入瓷罐内;空白对照组涂0。4ml生理盐水。用药后15min、30min、60min各测小白鼠痛阈一次,如果用药后放入瓷罐内60秒钟仍无反应,即将小白鼠取出,以免时间太长把脚烫伤,其痛阈可按60秒计算。
(3)结果。根据测得值比较给药前后变及组间变化,并计算痛阈提高率(%)=药后平均痛阈值—药前平均值/药前平均值×100%,结果见表2。结果表明竹鼠油烫伤膏能大幅度提高小鼠痛阈值,15分钟时达到58.3s,有很好的镇痛效果。
表2.对小鼠痛阈值影响试验结果
实施例7
将实施例1制备的一种竹鼠油创口膏对止血效果试验,使用步骤和效果如下:
(1)选取小白免。选取大小一致的家免10只,耳背部皮肤脱毛。
(2)止血时间测定。用保定盒固定好免子,分别在每只家兔两耳皮肤上切开小口长约5毫米(避开较大血管),右耳涂竹鼠油创口膏,左耳自然凝血,用滤纸法观察其出血时间,每10秒钟用淲纸吸干流出的血流一次,直至吸不到血液不止(从出血开始计时,到血流停止的时间为出血时间)。
(3)结果。根据测得止血时间表明,竹鼠油创口膏止血效果明显,结果见表3。
表3.对小白免止血试验结果
组别 | 左耳对照(s) | 右耳创口膏(s) |
1 | 560 | 110 |
2 | 680 | 120 |
3 | 700 | 130 |
4 | 660 | 120 |
5 | 760 | 120 |
6 | 690 | 120 |
7 | 750 | 130 |
8 | 590 | 110 |
9 | 650 | 120 |
10 | 610 | 110 |
实施例8
将实施例1制备的一种竹鼠油创口膏对灭菌效果试验,使用步骤和效果如下:
(1)药敏纸片的制备。选用新华1号定性滤纸,用打孔机打成直径为6mm的小圆片,根据需要将50片,放入的小瓶内,121℃灭菌15min,置100℃干燥箱内烘干备用。取纸片放入竹鼠油创口膏中浸泡20min备用。
(2)将大肠杆菌、葡萄球菌和链球菌的菌种无菌操作接种于5mL的营养肉汤液体培养基中,置于37℃培养箱中培养20h。取0.1mL培养的菌液,均匀涂布到营养琼脂培养基上,置于37℃培养箱中培养1h,取出,将含有竹鼠油创口膏的药纸片贴涂布细菌的营养琼脂培养基上,置于37℃培养箱中培养24h,然后观察结果。每种细菌做3个药敏试验重复。
(3)结果。测量抑菌圈的大小,结果见表4.结果表明竹鼠油创口膏对大肠杆菌、葡萄球菌和链球菌都是非常敏感,有很好的抑制作用。
表4.竹鼠油创口膏灭菌试验结果
组别 | 1号抑菌圈(cm) | 2号抑菌圈(cm) |
大肠杆菌 | 17.8 | 19.8 |
葡萄球菌 | 20.1 | 22.3 |
链球菌 | 21.1 | 22.4 |
实施例9
制备的一种竹鼠油创口膏在动物模型试验研究,使用步骤和效果如下:
1.实验动物。昆明小鼠10只,6~8周龄,雄雌各半,体质量22~25g。分笼饲养,保持自由。
2.造模。小鼠用干冰吸入麻醉,8%硫化钠溶液进行上背部的脱毛2cm×4cm。24h后,
小鼠用干冰吸入麻醉,在小鼠颈背部中央制造4个纵行长1cm的皮肤全层切口,左侧和右侧各2个创口,单只分笼饲养,建立损伤模型。
3.治疗方案。治疗期间各小鼠分笼饲养,自由饮水和标准饮食。左侧创口50μL生理盐水棉签涂抹,右侧创口涂竹鼠油烫伤膏50μL。每日两次,间隔12h,连续给药10 d。
4.治疗结果。记录治疗后第3天,左侧创口有脓性分泌物;右侧创口痂皮覆盖,可见少量肉芽组织,无渗出。第10天,左侧创口有痂皮覆盖,右侧创口皮肤干净无痂皮,已全愈合,并有毛发生长。
以上所述仅为本发明的优选实施例而已,并不用于限制本发明,对于本领域的技术人员来说,本发明可以有各种更改和变化。凡在本发明的精神和原则之内所作的任何修改、等同替换、改进等,均应包含在本发明的包含范围之内。
Claims (10)
1.一种竹鼠油创口膏,其特征在于,包括以下原料:
1)竹鼠油;
2)至少一种治创伤中草药;
3)至少一种乳化剂;
4) 至少一种粘合剂。
2.根据权利要求1所述竹鼠油创口膏,其特征在于,所述治创伤中草药为金狗毛、见血清、一点血、九死还魂草、菊叶三七、白芨、白花蛇舌草、半枝莲的一种或多种。
3.根据权利要求1所述竹鼠油创口膏,其特征在于,所述乳化剂为卵磷脂。
4.根据权利要求1所述竹鼠油创口膏,其特征在于,所述粘合剂为纤维素胶。
5.根据权利要求1所述竹鼠油创口膏,其特征在于,所述竹鼠油占所有原料的质量百分比不低于50%。
6.根据权利要求4述竹鼠油创口膏,其特征在于,所述竹鼠油占所有原料的质量百分比不低于60%。
7.根据权利要求1所述竹鼠油创口膏,其特征在于,所述乳化剂占所有原料的质量百分比不低于2%。
8.根据权利要求1所述竹鼠油创口膏,其特征在于,所述粘合剂占所有原料的质量百分比不低于1%。
9.一种如权利要求1或2所述竹鼠油创口膏的制备方法,其特征在于,包括以下步骤:
(1)称取各原料;
(2)将部分治创伤中草药分别磨成粉,过200目筛;
(3)把剩余治创伤中草药置于砂锅,加入饮用水,浸泡20-30分钟后,再加水没过药物,将砂锅放在炉火上煎煮,煮沸40-50分钟后,把药液倒出,获得第一次药液;
(4)在砂锅中再加入温水,进行第二次煎煮,煮沸30分钟后,倒出药液,与第一次药液混合,自然冷却后,加入竹鼠油和乳化剂混合后,充分乳化;
(5)把步骤(2)药粉和步骤(4)药液充分混合后,再加入粘合剂搅拌均匀成膏,即为一种竹鼠油创口膏。
10.一种如权利要求1-8任意一项所述一种竹鼠油创口膏在制备治疗创伤的药物中应用。
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