CN109414162A - 用于倾斜照明下视网膜吸收相以及暗场成像的系统、方法和装置 - Google Patents

用于倾斜照明下视网膜吸收相以及暗场成像的系统、方法和装置 Download PDF

Info

Publication number
CN109414162A
CN109414162A CN201780033204.7A CN201780033204A CN109414162A CN 109414162 A CN109414162 A CN 109414162A CN 201780033204 A CN201780033204 A CN 201780033204A CN 109414162 A CN109414162 A CN 109414162A
Authority
CN
China
Prior art keywords
light
imaging
illumination
phase
eye
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780033204.7A
Other languages
English (en)
Chinese (zh)
Inventor
T·勒弗瑞斯特
D·卡朋特拉斯
C·莫泽尔
M·库恩齐
F·巴哈尔-科恩
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ECOLE POLYTECH
Original Assignee
ECOLE POLYTECH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ECOLE POLYTECH filed Critical ECOLE POLYTECH
Publication of CN109414162A publication Critical patent/CN109414162A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/0008—Apparatus for testing the eyes; Instruments for examining the eyes provided with illuminating means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/14—Arrangements specially adapted for eye photography

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Eye Examination Apparatus (AREA)
  • Microscoopes, Condenser (AREA)
CN201780033204.7A 2016-05-13 2017-05-12 用于倾斜照明下视网膜吸收相以及暗场成像的系统、方法和装置 Pending CN109414162A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IB2016052787 2016-05-13
IBPCT/IB2016/052787 2016-05-13
IBPCT/IB2016/056806 2016-11-11
IB2016056806 2016-11-11
PCT/IB2017/052803 WO2017195163A1 (en) 2016-05-13 2017-05-12 System, method and apparatus for retinal absorption phase and dark field imaging with oblique illumination

Publications (1)

Publication Number Publication Date
CN109414162A true CN109414162A (zh) 2019-03-01

Family

ID=59055236

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780033204.7A Pending CN109414162A (zh) 2016-05-13 2017-05-12 用于倾斜照明下视网膜吸收相以及暗场成像的系统、方法和装置

Country Status (5)

Country Link
US (2) US11179033B2 (https=)
EP (2) EP3454719A1 (https=)
JP (3) JP6994472B2 (https=)
CN (1) CN109414162A (https=)
WO (1) WO2017195163A1 (https=)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111369510A (zh) * 2020-02-28 2020-07-03 四川大学华西医院 一种自动估计脉络膜厚度的方法
CN112051239A (zh) * 2019-06-05 2020-12-08 中国科学院上海光学精密机械研究所 基于动态散射系统的在探测面积受限情况下的成像方法
CN113271840A (zh) * 2018-12-12 2021-08-17 洛桑联邦理工学院 用于使用具有多个点源的经巩膜照明的临床设备的眼科系统和方法
CN114063275A (zh) * 2022-01-17 2022-02-18 北京九辰智能医疗设备有限公司 角膜内皮细胞成像系统、方法、设备和存储介质
CN115334953A (zh) * 2020-03-27 2022-11-11 洛桑联邦理工学院 多模态视网膜成像平台
CN115335751A (zh) * 2020-02-28 2022-11-11 元平台技术有限公司 眼睛跟踪眼底成像系统
JP2024529663A (ja) * 2021-08-08 2024-08-08 ザ ジェネラル ホスピタル コーポレイション 光干渉断層撮影に基づく流量定量化のための動的前方散乱信号の使用

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3454719A1 (en) * 2016-05-13 2019-03-20 Ecole Polytechnique Federale de Lausanne (EPFL) System, method and apparatus for retinal absorption phase and dark field imaging with oblique illumination
US10492951B2 (en) 2016-08-01 2019-12-03 Novartis Ag Method and apparatus for performing ophthalmic procedures removing undesirable features using laser energy
US11974809B2 (en) * 2017-06-13 2024-05-07 The Board Of Trustees Of The University Of Illinois Non-mydriatic, non-contact system and method for performing widefield fundus photographic imaging of the eye
CN108371540A (zh) * 2018-01-22 2018-08-07 深圳盛达同泽科技有限公司 视网膜数字成像系统及视网膜数字成像仪
EP3918405A4 (en) * 2019-02-03 2022-11-09 Bar Ilan University SYSTEM AND PROCEDURE FOR IMAGING VIA SCATTERING MEDIUM
KR102278782B1 (ko) * 2019-09-16 2021-07-20 주식회사 스몰머신즈 능동 가변 스펙클 조명 대면적 고해상도 영상 기기 및 이를 이용한 이미징 방법
US20220404601A1 (en) * 2019-09-26 2022-12-22 Ecole Polytechnique Federale De Lausanne (Epfl) System and methods for differential imaging using a lock-in camera
WO2021067515A1 (en) 2019-09-30 2021-04-08 The Regents Of The University Of Colorado, A Body Corporate Systems and methods for imaging and characterizing objects including the eye using non-uniform or speckle illumination patterns
US20230072066A1 (en) * 2019-11-25 2023-03-09 Optos Plc Choroidal Imaging
WO2021199772A1 (ja) * 2020-03-31 2021-10-07 国立大学法人東北大学 眼球内部組織の状態推定装置およびその方法
CN115697182A (zh) * 2020-06-15 2023-02-03 爱克透镜国际公司 测定眼睛的调节结构尺寸的装置和方法
NL2026025B1 (en) * 2020-06-15 2022-02-17 Akkolens Int B V Apparatus and method to measure accommodative structure of the eye
FI129077B (en) 2020-06-29 2021-06-30 Optomed Oyj Contact arrangement for eye examination instruments, eye examination instruments and procedure for eye contact with eye examination instruments
WO2022023809A1 (en) 2020-07-31 2022-02-03 Alcon Inc. Visualization and treatment of media opacity in eye
US20220039654A1 (en) * 2020-08-10 2022-02-10 Welch Allyn, Inc. Eye imaging devices
FI131536B1 (en) * 2020-12-21 2025-06-16 Optomed Oyj Eye examination device and eye examination procedure
CN112965261B (zh) * 2021-02-23 2022-10-28 山东仕达思生物产业有限公司 一种快速有效的基于机器视觉的智能校正显微镜光轴的方法及其实现系统
JP7672893B2 (ja) * 2021-06-25 2025-05-08 株式会社タムロン 光学系、眼底撮像装置および眼底撮像システム
JP7794589B2 (ja) * 2021-09-16 2026-01-06 株式会社トプコン 眼科装置
JP2024542007A (ja) 2021-11-19 2024-11-13 アルコン インコーポレイティド レーザ手術中の網膜放射曝露の低減
CA3234753A1 (en) 2021-11-19 2023-05-25 Zsolt Bor Evaluating and treating eye floaters
CA3234778A1 (en) 2021-11-19 2023-05-25 Zsolt Bor Performing laser vitreolysis on an eye with an intraocular lens
WO2023089414A1 (en) 2021-11-19 2023-05-25 Alcon Inc. Generating bubble jets to fragment and remove eye floaters
CA3234904A1 (en) 2021-11-19 2023-05-25 Utkarsh SHARMA Generating and evaluating two- and three-dimensional images of the interior of an eye
CA3234590A1 (en) 2021-11-19 2023-05-25 Zsolt Bor Determining radiant exposure at the retina during an ophthalmic procedure
CA3234551A1 (en) 2021-11-19 2023-05-25 Utkarsh SHARMA Imaging a target within an eye and calibrating imaging devices
US12467745B2 (en) 2021-11-19 2025-11-11 Alcon Inc. Anamorphic depth gauge for ophthalmic systems
AU2022389056A1 (en) * 2021-11-19 2024-05-02 Alcon Inc. Ophthalmic procedure contact lens with enhanced vitreous visualization
JP2024539226A (ja) 2021-11-19 2024-10-28 アルコン インコーポレイティド 深度範囲が拡張された光干渉断層撮影システム
US12558262B2 (en) 2021-11-19 2026-02-24 Alcon Inc. Visualization of vitreous floaters in the eye
EP4190450A1 (en) 2021-12-02 2023-06-07 Scienion GmbH Imaging apparatus for imaging a nozzle section of a droplet dispenser device, dispenser apparatus including the imaging apparatus, and applications thereof
WO2023175544A1 (en) 2022-03-17 2023-09-21 Ricoh Company, Ltd. Method of manufacturing laminate for battery, apparatus for manufacturing laminate for battery, method of manufacturing member for battery, and apparatus for manufacturing member for battery
JP7810981B2 (ja) * 2022-03-24 2026-02-04 株式会社ニコン 画像処理方法、画像処理装置、眼科装置、及びプログラム
US20250299325A1 (en) * 2022-04-30 2025-09-25 Earlysight Sa Method and use of transscleral optical imaging for detecting a disease
EP4327723A1 (en) * 2022-08-26 2024-02-28 EarlySight SA Retina tissue image acquisition
US20240353665A1 (en) * 2023-03-30 2024-10-24 California Institute Of Technology Angular ptychographic imaging with closed-form reconstruction
CN116990320B (zh) * 2023-09-27 2023-12-19 江西驰宇光电科技发展有限公司 一种用于疵病检测的暗场成像方法及装置
CN117398059A (zh) * 2023-12-12 2024-01-16 中国科学院长春光学精密机械与物理研究所 基于差分相衬成像的视网膜成像方法
CN117678967B (zh) * 2024-01-18 2024-08-23 中国科学院长春光学精密机械与物理研究所 一种环形同轴明暗场同步光学相干层析成像装置

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3954329A (en) * 1972-09-25 1976-05-04 Retina Foundation Wide-angle opthalmoscope employing transillumination
CN1226143A (zh) * 1996-07-24 1999-08-18 研究发展基金会 便携式眼腈成象俘获装置
CN1330524A (zh) * 1998-12-10 2002-01-09 卡尔蔡斯耶拿有限公司 无接触式测量眼睛轴长和/或角膜曲率和/或前房深度的,尤其是iol测量的装置和方法
CN1665440A (zh) * 2002-05-08 2005-09-07 狮眼研究所有限公司 多功能成像装置和用于该装置的适配器
US20070159600A1 (en) * 2003-04-08 2007-07-12 Medibell Medical Vision Technologies, Ltd. Transcleral opthalmic illumination method and system
US20090153798A1 (en) * 2005-07-22 2009-06-18 Manfred Dick Device and method for monitoring, documenting and/or diagnosing the fundus
CN102525410A (zh) * 2010-10-28 2012-07-04 欧科路光学器械有限公司 照明系统和方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200362A (en) 1972-09-25 1980-04-29 Retina Foundation Ophthalmoscope with uniform illumination
US3954392A (en) 1973-08-02 1976-05-04 Allied Chemical Corporation Copper phthalocyanine N-Di-N-butylaminoalkyl sulfonamide, quaternized solutions of the quaternary compound, and paper dyeing therewith
US4213678A (en) 1977-09-29 1980-07-22 Retina Foundation Scanning ophthalmoscope for examining the fundus of the eye
US5099354A (en) * 1988-09-14 1992-03-24 Washington University Kit for converting a slit lamp biomicroscope into a single aperture confocal scanning biomicroscope
US6464364B2 (en) 2000-01-27 2002-10-15 Aoptix Technologies, Inc. Deformable curvature mirror
JP2003000548A (ja) * 2001-06-18 2003-01-07 Konan Medical Inc 前眼部観察装置
FR2828396B1 (fr) 2001-08-12 2004-05-07 Samuel Henri Bucourt Dispositif de mesure des aberrations d'un systeme de type oeil
JP4157839B2 (ja) 2001-08-30 2008-10-01 ユニバーシティー オブ ロチェスター 生体眼の網膜領域撮像方法及びそのシステム
AU2003245458A1 (en) 2002-06-12 2003-12-31 Advanced Research And Technology Institute, Inc. Method and apparatus for improving both lateral and axial resolution in ophthalmoscopy
DE10302401A1 (de) 2003-01-21 2004-07-29 Leica Microsystems (Schweiz) Ag Operationsmikroskop
DE10349091A1 (de) 2003-10-22 2005-05-25 Carl Zeiss Meditec Ag Beleuchtungseinheit für Funduskameras und/oder Ophthalmoskope
JP2005168941A (ja) 2003-12-15 2005-06-30 Kowa Co 眼科撮像方法、眼科光学アダプタ、および眼科光学装置
US8450674B2 (en) 2009-11-10 2013-05-28 California Institute Of Technology Acoustic assisted phase conjugate optical tomography
US7665844B2 (en) 2006-10-18 2010-02-23 Lawrence Livermore National Security Llc High-resolution adaptive optics scanning laser ophthalmoscope with multiple deformable mirrors
EP1964510A1 (en) * 2007-02-27 2008-09-03 National University of Ireland Galway Imaging of phase objects
WO2012102887A2 (en) 2011-01-24 2012-08-02 The Board Of Trustees Of The University Of Illinois Computational adaptive optics for interferometric synthetic aperture microscopy and other interferometric imaging
US8237835B1 (en) * 2011-05-19 2012-08-07 Aeon Imaging, LLC Confocal imaging device using spatially modulated illumination with electronic rolling shutter detection
US9060718B2 (en) 2012-02-13 2015-06-23 Massachusetts Institute Of Technology Methods and apparatus for retinal imaging
WO2013148360A1 (en) 2012-03-30 2013-10-03 Trustees Of Boston University Phase contrast microscopy with oblique back-illumination
WO2015179452A1 (en) * 2014-05-19 2015-11-26 The Regents Of The University Of California Fourier ptychographic microscopy with multiplexed illumination
JP6603074B2 (ja) 2015-08-25 2019-11-06 株式会社トプコン 眼底撮影装置
EP3454719A1 (en) 2016-05-13 2019-03-20 Ecole Polytechnique Federale de Lausanne (EPFL) System, method and apparatus for retinal absorption phase and dark field imaging with oblique illumination

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3954329A (en) * 1972-09-25 1976-05-04 Retina Foundation Wide-angle opthalmoscope employing transillumination
CN1226143A (zh) * 1996-07-24 1999-08-18 研究发展基金会 便携式眼腈成象俘获装置
CN1330524A (zh) * 1998-12-10 2002-01-09 卡尔蔡斯耶拿有限公司 无接触式测量眼睛轴长和/或角膜曲率和/或前房深度的,尤其是iol测量的装置和方法
CN1665440A (zh) * 2002-05-08 2005-09-07 狮眼研究所有限公司 多功能成像装置和用于该装置的适配器
US20070159600A1 (en) * 2003-04-08 2007-07-12 Medibell Medical Vision Technologies, Ltd. Transcleral opthalmic illumination method and system
US20090153798A1 (en) * 2005-07-22 2009-06-18 Manfred Dick Device and method for monitoring, documenting and/or diagnosing the fundus
CN102525410A (zh) * 2010-10-28 2012-07-04 欧科路光学器械有限公司 照明系统和方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LEI TIAN ET.AL: ""Quantitative differential phase contrast imaging in an LED array microscope"", 《OPTICS EXPRESS》 *

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113271840A (zh) * 2018-12-12 2021-08-17 洛桑联邦理工学院 用于使用具有多个点源的经巩膜照明的临床设备的眼科系统和方法
CN113271840B (zh) * 2018-12-12 2025-06-24 洛桑联邦理工学院 用于使用具有多个点源的经巩膜照明的临床设备的眼科系统和方法
CN112051239A (zh) * 2019-06-05 2020-12-08 中国科学院上海光学精密机械研究所 基于动态散射系统的在探测面积受限情况下的成像方法
CN112051239B (zh) * 2019-06-05 2024-04-12 中国科学院上海光学精密机械研究所 基于动态散射系统的在探测面积受限情况下的成像方法
CN111369510A (zh) * 2020-02-28 2020-07-03 四川大学华西医院 一种自动估计脉络膜厚度的方法
CN111369510B (zh) * 2020-02-28 2022-07-01 四川大学华西医院 一种自动估计脉络膜厚度的方法
CN115335751A (zh) * 2020-02-28 2022-11-11 元平台技术有限公司 眼睛跟踪眼底成像系统
CN115334953A (zh) * 2020-03-27 2022-11-11 洛桑联邦理工学院 多模态视网膜成像平台
JP2024529663A (ja) * 2021-08-08 2024-08-08 ザ ジェネラル ホスピタル コーポレイション 光干渉断層撮影に基づく流量定量化のための動的前方散乱信号の使用
JP7846210B2 (ja) 2021-08-08 2026-04-14 ザ ジェネラル ホスピタル コーポレイション 光干渉断層撮影に基づく流量定量化のための動的前方散乱信号の使用
CN114063275A (zh) * 2022-01-17 2022-02-18 北京九辰智能医疗设备有限公司 角膜内皮细胞成像系统、方法、设备和存储介质

Also Published As

Publication number Publication date
EP3454719A1 (en) 2019-03-20
JP2022043142A (ja) 2022-03-15
JP2023055993A (ja) 2023-04-18
JP2019518511A (ja) 2019-07-04
JP6994472B2 (ja) 2022-02-04
US11179033B2 (en) 2021-11-23
JP7688925B2 (ja) 2025-06-05
US20190290124A1 (en) 2019-09-26
JP7235355B2 (ja) 2023-03-08
US20220117485A1 (en) 2022-04-21
WO2017195163A1 (en) 2017-11-16
EP4008237A1 (en) 2022-06-08
US11911107B2 (en) 2024-02-27

Similar Documents

Publication Publication Date Title
US11911107B2 (en) System, method and apparatus for retinal absorption phase and dark field imaging with oblique illumination
JP4621496B2 (ja) ラインスキャン検眼鏡
Mainster et al. Scanning laser ophthalmoscopy retroillumination: applications and illusions
US9517009B2 (en) Structured illumination ophthalmoscope
JP2023523245A (ja) チャネル符号化スラブを用いたｏｃｔ ｅｎ ｆａｃｅ病変セグメンテーション
CN115334953A (zh) 多模态视网膜成像平台
US20250334513A1 (en) Systems And Methods For Imaging And Characterizing Objects Including The Eye Using Non-Uniform Or Speckle Illumination Patterns
JP2022527421A (ja) 物体の背後の面から後方散乱される光に基づく生体内物体識別、計数及び撮像
Shao et al. Non-interferometric volumetric imaging in living human retina by confocal oblique scanning laser ophthalmoscopy
Schramm et al. 3D retinal imaging and measurement using light field technology
Carles et al. Combined high contrast and wide field of view in the scanning laser ophthalmoscope through dual detection of light paths
Zhao Light sheet microscopy for imaging cellular features of unstained tissues
Salas Manipulation of the illumination of an Adaptive Optics Flood Illumination Ophthalmoscope for functional imaging of the retina in-vivo
Xiao Adaptive optics in full-field spatially incoherent interferometry and its retinal imaging
Mozaffari Structural and Functional Adaptive Optics Retinal Imaging
Feng Label-free Quantitative Retinal Imaging with Adaptive Optics Computational Ophthalmoscopy
Li Computational Methods for Enhancements of Optical Coherence Tomography
Wahl Aberration correction with sensorless adaptive optics for imaging the mouse retina
Logean On Phase Contrast Imaging of the Inner Retina
Geng Wavefront sensing and high resolution adaptive optics imaging in the living rodent eye
Laforest et al. Quantitative phase imaging of retinal cells
Mayne Dynamic Aperture Imaging with an Adaptive Optics Scanning Laser Ophthalmoscope as an Approach to Studying Light Scatter in the Retina
Edrei Controlling light Propagation in complex media for Imaging, focusing and Brillouin measurements
Jeong Holographic optical coherence imaging of living tissue
Mariotti Processing of adaptive optics photoreceptor images and application to the study of healthy and diabetic retinas

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination