CN109382025B - Leak-proof mixing device for in-vitro diagnostic equipment - Google Patents
Leak-proof mixing device for in-vitro diagnostic equipment Download PDFInfo
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- CN109382025B CN109382025B CN201811498321.3A CN201811498321A CN109382025B CN 109382025 B CN109382025 B CN 109382025B CN 201811498321 A CN201811498321 A CN 201811498321A CN 109382025 B CN109382025 B CN 109382025B
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- leakage
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- groove
- eccentric
- mixing head
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- 238000002156 mixing Methods 0.000 title claims abstract description 95
- 238000000338 in vitro Methods 0.000 title claims abstract description 15
- 238000006243 chemical reaction Methods 0.000 claims abstract description 58
- 239000007788 liquid Substances 0.000 claims abstract description 40
- 230000005540 biological transmission Effects 0.000 claims abstract description 6
- 230000002265 prevention Effects 0.000 claims description 8
- 230000006698 induction Effects 0.000 claims description 7
- 230000000149 penetrating effect Effects 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 9
- 238000000034 method Methods 0.000 abstract description 5
- 239000011324 bead Substances 0.000 description 7
- 238000004140 cleaning Methods 0.000 description 7
- 230000000670 limiting effect Effects 0.000 description 7
- 238000007789 sealing Methods 0.000 description 7
- 238000001514 detection method Methods 0.000 description 4
- 238000005406 washing Methods 0.000 description 3
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000003018 immunoassay Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 239000012295 chemical reaction liquid Substances 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/23—Mixers with rotary stirring devices in fixed receptacles; Kneaders characterised by the orientation or disposition of the rotor axis
- B01F27/232—Mixers with rotary stirring devices in fixed receptacles; Kneaders characterised by the orientation or disposition of the rotor axis with two or more rotation axes
- B01F27/2322—Mixers with rotary stirring devices in fixed receptacles; Kneaders characterised by the orientation or disposition of the rotor axis with two or more rotation axes with parallel axes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
- B01F27/808—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with stirrers driven from the bottom of the receptacle
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
- B01F27/90—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with paddles or arms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/181—Preventing generation of dust or dirt; Sieves; Filters
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/40—Mounting or supporting mixing devices or receptacles; Clamping or holding arrangements therefor
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention discloses a leakage-proof mixing device for in-vitro diagnostic equipment, which comprises a leakage-proof groove arranged on a mounting seat, wherein the top edge of the leakage-proof groove is outwards expanded to form a collecting opening, a first eccentric mixing head driven by a power mechanism is arranged in the leakage-proof groove, the first eccentric mixing head comprises a positioning groove for clamping a reaction cup and a shielding cap with a downward opening, and a liquid outlet hole is formed in the groove wall of the positioning groove; the first rotating shaft fixedly connected to the shielding cap downwards penetrates through the through hole in the bottom wall of the leakage-proof groove and is in transmission connection with the driving gear of the power mechanism, the edge of the through hole is vertically bent upwards to form a leakage-proof boss with a cylindrical structure, and the top of the leakage-proof boss extends upwards into the shielding cap; the eccentric distance d between the central axis of the positioning groove and the central axis of the first rotating shaft is 0.5-3.0mm. The invention has simple structure, adjustable mixing intensity and good mixing effect, and can collect the liquid splashed outside through the leakage-proof groove in the mixing process, prevent the liquid from flowing out or splashing to the machine and protect the machine.
Description
Technical Field
The invention relates to an in-vitro detection device, in particular to a leakage-proof mixing device for an in-vitro diagnosis device.
Background
Existing in vitro diagnostic devices (such as chemiluminescent immunoassay analyzer, biochemical analyzer, nucleic acid analyzer, etc.) mostly use a chemiluminescent or bioluminescent system as an indicator system for antigen-antibody reaction, thereby quantitatively detecting antigens or antibodies. When separating and purifying a sample, magnetic beads are generally utilized to adsorb specific antibodies or receptors (i.e. target bodies) in the sample, then waste liquid in a reaction cup is sucked out, injected liquid is washed, and substances which are not combined with antigens or antibodies in the reaction liquid and other interference substances loaded on the magnetic beads are removed. From this, the bead washing is a critical factor affecting the detection result. The existing magnetic bead cleaning device consists of a hair washing assembly and a reaction cup rotating disc assembly, and the hair washing assembly integrally lifts and lowers to absorb waste liquid of the reaction cup or injects cleaning liquid into the reaction cup, and the magnetic beads in the reaction cup and the cleaning liquid on the rotating disc are fully and uniformly mixed by the mixing device so as to ensure the cleaning effect. The invention patent application CN103599898A discloses a full-automatic chemiluminescence immunoassay analyzer magnetic bead cleaning device, which comprises a rotary disk driven by a rotary motor, a mixing device and a magnet adsorption device, wherein the mixing device is composed of a mixing eccentric friction wheel (driven by the motor) and a pushing mechanism, the friction wheel drives a reaction cup to rotate, when a long shaft of the friction wheel is close to the reaction cup, the reaction cup inclines to the pushing mechanism, a spring of the pushing mechanism is in a compression stress state, and when a short shaft of the friction wheel is close to the reaction cup, the restoring force of the spring pushes the reaction cup to incline to one side of the mixing wheel, and the reaction cup is reciprocated in such a way, so that the magnetic beads in the reaction cup and cleaning liquid are fully mixed. The liquid is easy to splash in the mixing process, so that cross contamination is caused and the instrument is polluted; the mixing intensity cannot be adjusted by adopting a mixing mode of extruding the reaction cup by an eccentric friction wheel.
Disclosure of Invention
The invention aims to provide a leak-proof mixing device for in-vitro diagnostic equipment, which not only ensures the mixing effect, but also completely avoids liquid in a reaction cup from splashing to a machine in the mixing process.
In order to achieve the above purpose, the invention adopts the following technical scheme:
The invention relates to a leak-proof mixing device for in-vitro diagnostic equipment, which comprises a leak-proof groove arranged on a mounting seat, wherein the top edge of the leak-proof groove is outwards expanded to form a collecting opening, a first eccentric mixing head driven by a power mechanism is arranged in the leak-proof groove, the first eccentric mixing head comprises a positioning groove for clamping a reaction cup and a shielding cap with a downward opening, and a liquid outlet is formed in the groove wall of the positioning groove; the first rotating shaft fixedly connected to the shielding cap downwards penetrates through a through hole in the bottom wall of the leakage-proof groove and is in transmission connection with a driving gear of the power mechanism, the edge of the through hole is vertically bent upwards to form a leakage-proof boss with a cylindrical structure, and the top of the leakage-proof boss extends upwards into the shielding cap; the eccentric distance d between the central axis of the positioning groove and the central axis of the first rotating shaft is 0.5-3.0mm.
The shielding cap of the first eccentric mixing head is of a cylindrical structure, an elliptic structure, a polygonal column structure or a conical frustum structure with a small upper part and a large lower part.
The shielding cap of the first eccentric mixing head is of a truncated cone structure with a small upper part and a large lower part.
The power mechanism comprises a vertical plate arranged on the mounting seat, a sliding rail and a lifting motor are arranged on the vertical plate, the lifting motor drives a rotating assembly to slide up and down along the sliding rail through a transmission pair, the rotating assembly comprises a mounting frame arranged on the sliding rail in a sliding manner, the bottom of the mounting frame is provided with a rotating motor, the rotating motor is sleeved on an output shaft of the rotating motor, a driving gear is arranged in a gear seat arranged at the top of the mounting frame in a rotating manner, a first driven gear meshed with the driving gear is arranged in the gear seat, and the bottom of the first rotating shaft is fixedly arranged in the first driven gear in a penetrating manner.
The first rotary shaft positioned on the upper side and the lower side of the first driven gear is sleeved with a first bearing sleeve which is in running fit with the gear seat.
The gear seat positioned on the right side of the driving gear is internally provided with a second driven gear meshed with the driving gear, a second rotating shaft extending upwards is fixedly connected in the second driven gear, and the top of the second rotating shaft is fixedly connected with a second eccentric mixing head with the same structure as the first eccentric mixing head.
The second rotating shafts positioned on the upper side and the lower side of the second driven gear are sleeved with second bearing sleeves, and the second bearing sleeves are in running fit with the gear seat.
Be provided with the support that is L shape structure on the mount pad, the interval be provided with on the horizontal pole of support with the spacing hole of first reaction cup of first rotation axis coaxial line and with the spacing hole of second reaction cup of second rotation axis coaxial line, first reaction cup spacing hole with first eccentric mixing head corresponds the setting from top to bottom, the spacing hole of second reaction cup with the upper and lower correspondence of second eccentric mixing head sets up.
The mounting frame is provided with an induction sheet, and the vertical plate is provided with a position sensor for detecting signals of the induction sheet.
And a leakage-proof sensor is arranged on the side wall of the leakage-proof groove.
The invention has the advantages of simple structure, adjustable mixing strength and good mixing effect, and can collect the liquid splashed outside through the leakage-proof groove in the mixing process so as to prevent the liquid from flowing out or splashing on the machine. The advantages of the invention are embodied in the following points: (1) When the liquid is uniformly mixed, the liquid splashed from the reaction cup flows into the positioning groove along the wall of the reaction cup, flows out from the liquid outlet hole on the positioning groove and falls on the shielding cap, and slides from the shielding cap with the truncated cone-shaped structure to the bottom of the leakage-proof groove to prevent the liquid from flowing out from the leakage-proof groove; meanwhile, the liquid outlet holes can ensure that liquid flows out of the positioning groove in time, so that the influence on the uniform mixing effect caused by crystallization of the liquid in the positioning groove is avoided; (2) The shielding cap of the first eccentric mixing head is overlapped with the leakage-proof groove in a mixing state or a non-mixing state, so that liquid is prevented from flowing out of the leakage-proof groove; when the liquid discharge pipe communicated with the leakage-proof groove is blocked, the leakage-proof sensor triggers to send out a signal when the liquid level in the leakage-proof groove rises to the position of the leakage-proof sensor, so that a worker is reminded of stopping the machine for maintenance, and the machine is protected; (3) The height of the first eccentric mixing head can be adjusted by the lifting motor, the speed of the rotating motor determines the mixing intensity of liquid in the reaction cup, the liquid mixing effect is ensured by adjusting the height and the speed of the first eccentric mixing head, meanwhile, the first eccentric mixing head revolves along with the first rotating shaft and enables the reaction cup to shake, and the second eccentric mixing head revolves and enables the reaction cup to shake, so that the liquid in the reaction cup is fully mixed, the reaction is complete, and the reliability of the detection result is ensured; (4) The second eccentric mixing head is used for mixing the reaction cup with small adding amount of the reaction reagent, and liquid splashing can be completely avoided due to the small mixing amount; the second eccentric mixing head and the first eccentric mixing head work simultaneously, so that mixing efficiency is improved.
Drawings
Fig. 1 is a schematic structural view of the present invention.
Fig. 2 is a schematic view of the structure of the present invention (with the mounting base and leak-proof groove omitted).
Fig. 3 is an installation state diagram of the present invention.
Detailed Description
As shown in fig. 1-3, the leak-proof mixing device for the in-vitro diagnostic equipment comprises a leak-proof groove 2.1 arranged on the side wall of a cylinder 1.1 of a mounting seat 1, a leak-proof sensor 2.3 is arranged on the side wall of the leak-proof groove 2.1, the signal output end of the leak-proof sensor 2.3 is electrically connected with the signal output end of a controller, when a drain pipeline of the leak-proof groove 2.1 is blocked, the liquid level in the leak-proof groove 2.1 rises to the position of the leak-proof sensor, the leak-proof sensor triggers to send a signal to the controller, and the controller sends a complete machine shutdown instruction to protect a machine; the top edge of the leakage prevention groove 2.1 is outwards expanded to form a collecting port, a first eccentric mixing head 3 driven by a power mechanism is arranged in the leakage prevention groove 2.1, the first eccentric mixing head 3 comprises a positioning groove 3.1 for clamping the reaction cup and a shielding cap 3.2 with a downward opening, a liquid outlet hole 3.3 is formed in the groove wall of the positioning groove 3.1 of the first eccentric mixing head 3, liquid in the positioning groove 3.1 is ensured to be timely discharged into the leakage prevention groove 2.1, the liquid in the positioning groove 3.1 is prevented from crystallizing to influence the mixing effect, the shielding cap 3.2 is of a conical frustum-shaped structure with a small top and a large bottom, so that the liquid is convenient to slide into the leakage prevention groove 2.1, a through hole fixedly connected to the shielding cap 3.2 downwards penetrates out of the bottom wall of the leakage prevention groove 2.1 and a driving gear 4.1 of the power mechanism, a fixing cap 3.5 is arranged at the top of the sealing cap 3.5, the sealing cap 3.4 is sleeved on the first rotating shaft 3.4 and is prevented from being in a state of being overlapped with the sealing cap 2.2.1 by the shielding cap 3.6, and the sealing cap 2.2 is prevented from being overlapped with the top of the sealing cap 2.2 when the sealing cap 2.1 is in a state of being overlapped with the sealing cap 2.2; the eccentric distance between the central axis of the positioning groove 3.1 and the central axis of the first rotating shaft 3.4 is 0.5-3.0mm, so that the reaction cup can shake while rotating along with the first rotating shaft 3.4, and the uniform mixing effect is ensured.
As shown in fig. 1 and 3, the power mechanism comprises a vertical plate 4.2 vertically arranged on the mounting seat 1, a sliding rail 4.3 and a lifting motor 4.4 are arranged on the vertical plate 4.2, the lifting motor 4.4 drives a rotating assembly to slide up and down along the sliding rail 4.3 through a transmission pair, the rotating assembly comprises a mounting frame 4.5 arranged on the sliding rail 4.3 in a sliding manner, a rotating motor 4.6 is arranged at the bottom of the mounting frame 4.5, a motor shaft of the rotating motor 4.6 is connected with an output shaft 4.13 which extends vertically upwards through a coupling, a driving gear 4.1 is sleeved on the output shaft 4.13 and is rotatably arranged in a gear seat 4.7 at the top of the mounting frame 4.5, a first driven gear 4.8 meshed with the driving gear 4.1 is arranged in the gear seat 4.7, the bottom of the first rotating shaft 3.4 is fixedly arranged in the first driven gear 4.8 in a penetrating manner, a first rotating shaft 3.4.4 arranged at the upper side and the lower side of the first driven gear 4.8 is sleeved with a first bearing 4.9, and the first bearing 4.9 is matched with the first bearing 4.9; be provided with induction piece 7.1 on the mounting bracket 4.5, be provided with on the riser 4.2 and detect the position sensor 7.2 of induction piece 7.1 signal detects the signal of induction piece 7.1 through position sensor 7.2, and then the height of accurate control rotating assembly, through the rotational speed adjustment mixing intensity of adjusting rotating electrical machines 4.6, guarantees the mixing effect.
As shown in fig. 1-3, in order to improve the mixing efficiency, a second driven gear 4.10 meshed with the driving gear 4.1 is arranged in a gear seat 4.7 positioned on the right side of the driving gear 4.1, a second bearing sleeve 4.12 is sleeved on a second rotating shaft 4.11 positioned on the upper side and the lower side of the second driven gear 4.10, the second bearing sleeve 4.12 is in rotating fit with the gear seat 4.7, a second rotating shaft 4.11 extending upwards is fixedly connected in the second driven gear 4.10, a second eccentric mixing head 5 is fixedly connected at the top of the second rotating shaft 4.11, the first eccentric mixing head 3 of the structure of the second eccentric mixing head 5 is completely the same, the second eccentric mixing head 5 can uniformly mix reaction cups after adding reaction reagents, and the reliability of sample detection results is further ensured. When the rotary motor 4.6 works, the driving gear 4.1 drives the first driven gear 4.10 and the second driven gear 4.10 to rotate simultaneously, so that the first eccentric mixing head 3 and the second eccentric mixing head 5 are driven to rotate simultaneously, the mixing of the two reaction cups is realized, and the mixing efficiency is improved; the lifting motor 4.4 drives the rotating assembly to ascend or descend, so that the heights of the first eccentric mixing head 3 and the second eccentric mixing head 5 are adjusted simultaneously.
As shown in fig. 1 and 3, in order to further ensure the stability of the reaction cup, a bracket 6.1 with an L-shaped structure is arranged on the mounting seat 1, a first reaction cup limiting hole 6.2 coaxial with the first rotating shaft 3.4 and a second reaction cup limiting hole 6.3 coaxial with the second rotating shaft 4.11 are arranged on a cross rod of the bracket 6.1 at intervals, the first reaction cup limiting hole 6.2 and the first eccentric mixing head 3 are correspondingly arranged up and down, the second reaction cup limiting hole 6.3 and the second eccentric mixing head 5 are correspondingly arranged up and down, the first reaction cup limiting hole 6.2 and the second reaction cup limiting hole 6.3 are positioned above the reaction cup rotating disc, have a limiting effect, limit the vibration amplitude of the reaction cup, and reduce the probability of liquid splashing.
The first eccentric mixing head and the second eccentric mixing head of the mixing device are respectively positioned below an inner ring reaction cup hole and an outer ring reaction cup hole of the reaction cup rotating disc. During operation, the rotary disk of the reaction cup rotates to bring the reaction cup to be uniformly mixed to a mixing position, the bottom of the reaction cup is clamped in the first eccentric mixing head 3 and/or the second eccentric mixing head 5, the heights of the first eccentric mixing head 3 and the second eccentric mixing head 5 are adjusted through the lifting motor 4.4, the rotary motor 4.6 drives the first driven gear 4.8 and the second driven gear 4.10 to simultaneously rotate through the driving gear 4.1, and then the first eccentric mixing head 3 and the second eccentric mixing head 5 are driven to simultaneously rotate to uniformly mix liquid in the reaction cup. During cleaning, liquid hung on the liquid injection needle and splashed from the cup mouth of the reaction cup in the rotation process of the first eccentric mixing head 3 directly enter the bottom of the leakage-proof groove 2.1 through the collecting port, or flow into the positioning groove 3.1 along the cup body of the reaction cup, then fall onto the shielding cap 3.2 in a cone frustum-shaped structure through the liquid outlet hole 3.3, slide into the leakage-proof groove 2.1 through the shielding cap 3.2, prevent the liquid from flowing onto a machine, and protect the machine environment.
Claims (7)
1. A leak protection mixing arrangement for external diagnostic equipment, its characterized in that: the anti-leakage device comprises an anti-leakage groove (2.1) arranged on a mounting seat (1), wherein the top edge of the anti-leakage groove (2.1) is outwards expanded to form a collecting opening, a first eccentric mixing head (3) driven by a power mechanism is arranged in the anti-leakage groove (2.1), the first eccentric mixing head (3) comprises a positioning groove (3.1) for clamping a reaction cup and a shielding cap (3.2) with a downward opening, and a liquid outlet hole (3.3) is formed in the groove wall of the positioning groove (3.1);
The first rotating shaft (3.4) fixedly connected to the shielding cap (3.2) downwards penetrates through a through hole in the bottom wall of the leakage prevention groove (2.1) to be in transmission connection with the driving gear (4.1) of the power mechanism, the edge of the through hole is vertically bent upwards to form a leakage prevention boss (2.2) with a cylindrical structure, and the top of the leakage prevention boss (2.2) upwards extends into the shielding cap (3.2); the eccentric distance d between the central axis of the positioning groove (3.1) and the central axis of the first rotating shaft (3.4) is 0.5-3.0mm;
The power mechanism comprises a vertical plate (4.2) vertically arranged on the mounting seat (1), a sliding rail (4.3) and a lifting motor (4.4) are arranged on the vertical plate (4.2), the lifting motor (4.4) drives a rotating assembly to slide up and down along the sliding rail (4.3) through a transmission pair, the rotating assembly comprises a mounting frame (4.5) arranged on the sliding rail (4.3) in a sliding manner, a rotating motor (4.6) is arranged at the bottom of the mounting frame (4.5), a driving gear (4.1) sleeved on an output shaft of the rotating motor (4.6) is rotatably arranged in a gear seat (4.7) at the top of the mounting frame (4.5), a first driven gear (4.8) meshed with the driving gear (4.1) is arranged in the gear seat (4.7), and the bottom of the first rotating shaft (3.4) is fixedly arranged in the first driven gear (4.8) in a penetrating manner; a first bearing sleeve (4.9) is sleeved on a first rotating shaft (3.4) positioned on the upper side and the lower side of a first driven gear (4.8), and the first bearing sleeve (4.9) is in rotary fit with a gear seat (4.7); an induction piece (7.1) is arranged on the mounting frame (4.5), and a position sensor (7.2) for detecting signals of the induction piece (7.1) is arranged on the vertical plate (4.2).
2. The leak-proof blending apparatus for an in vitro diagnostic device according to claim 1, wherein: the shielding cap (3.2) of the first eccentric mixing head (3) is of a cylindrical structure, an elliptic structure, a polygonal column structure or a conical frustum structure with a small upper part and a large lower part.
3. The leak-proof blending apparatus for an in vitro diagnostic device according to claim 2, wherein: the shielding cap (3.2) of the first eccentric mixing head (3) is of a truncated cone-shaped structure with a small upper part and a large lower part.
4. The leak-proof blending apparatus for an in vitro diagnostic device according to claim 1, wherein: the gear seat (4.7) positioned on the right side of the driving gear (4.1) is internally provided with a second driven gear (4.10) meshed with the driving gear (4.1), a second rotating shaft (4.11) extending upwards is fixedly connected in the second driven gear (4.10), and the top of the second rotating shaft (4.11) is fixedly connected with a second eccentric mixing head (5) with the same structure as the first eccentric mixing head (3).
5. The leak-proof blending apparatus for an in vitro diagnostic device of claim 4, wherein: the second rotary shafts (4.11) positioned on the upper side and the lower side of the second driven gear (4.10) are sleeved with second bearing sleeves (4.12), and the second bearing sleeves (4.12) are in running fit with the gear seat (4.7).
6. The leak-proof blending apparatus for an in vitro diagnostic device of claim 4, wherein: be provided with support (6.1) that are L shape structure on mount pad (1), the interval be provided with on the horizontal pole of support (6.1) with first reaction cup spacing hole (6.2) of first rotation axis (3.4) coaxial line and with second reaction cup spacing hole (6.3) of second rotation axis (4.11) coaxial line, first reaction cup spacing hole (6.2) with correspond from top to bottom setting of first eccentric mixing head (3), second reaction cup spacing hole (6.3) with correspond from top to bottom setting of second eccentric mixing head (5).
7. The leak-proof blending apparatus for an in vitro diagnostic device according to claim 1, wherein: the side wall of the leakage-proof groove (2.1) is provided with a leakage-proof sensor (2.3).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811498321.3A CN109382025B (en) | 2018-12-08 | 2018-12-08 | Leak-proof mixing device for in-vitro diagnostic equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811498321.3A CN109382025B (en) | 2018-12-08 | 2018-12-08 | Leak-proof mixing device for in-vitro diagnostic equipment |
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| Publication Number | Publication Date |
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| CN109382025A CN109382025A (en) | 2019-02-26 |
| CN109382025B true CN109382025B (en) | 2024-06-28 |
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| WO2021007853A1 (en) * | 2019-07-18 | 2021-01-21 | 烟台艾德康生物科技有限公司 | Fully-automatic magnetic bead cleaning device |
| CN112198330A (en) * | 2020-09-27 | 2021-01-08 | 深圳市国赛生物技术有限公司 | Magnetic bead cleaning and separating device |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN209302615U (en) * | 2018-12-08 | 2019-08-27 | 安图实验仪器(郑州)有限公司 | Leakproof evenly mixing device for in-vitro diagnosis equipment |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07260794A (en) * | 1994-03-23 | 1995-10-13 | Omron Corp | Stirring mechanism of sample preparation device |
| KR100444594B1 (en) * | 2002-07-04 | 2004-08-16 | 삼성전자주식회사 | apparatus and method for adjusting a head gap in an inkjet printer |
| JP2004154651A (en) * | 2002-11-05 | 2004-06-03 | Sanyo Electric Co Ltd | Shaker |
| CN104297039B (en) * | 2014-09-25 | 2017-01-11 | 深圳市奥特库贝科技有限公司 | Novel magnetic separation mechanism |
| CN104237545A (en) * | 2014-09-30 | 2014-12-24 | 博奥赛斯（天津）生物科技有限公司 | Chemiluminescent immune assay blending device |
| CN206027606U (en) * | 2016-09-14 | 2017-03-22 | 四川迈克生物医疗电子有限公司 | Lifting mechanism |
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2018
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN209302615U (en) * | 2018-12-08 | 2019-08-27 | 安图实验仪器(郑州)有限公司 | Leakproof evenly mixing device for in-vitro diagnosis equipment |
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