CN109381693A - A kind of Chinese materia medica preparation and preparation method thereof for treating rheumatism bone disease - Google Patents

A kind of Chinese materia medica preparation and preparation method thereof for treating rheumatism bone disease Download PDF

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Publication number
CN109381693A
CN109381693A CN201910002662.5A CN201910002662A CN109381693A CN 109381693 A CN109381693 A CN 109381693A CN 201910002662 A CN201910002662 A CN 201910002662A CN 109381693 A CN109381693 A CN 109381693A
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parts
radix
root
rhizoma
ingredient
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耿文
李振国
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    • AHUMAN NECESSITIES
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714Aconitum (monkshood)
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
    • A61K31/122Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A61K31/125Camphor; Nuclear substituted derivatives thereof
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/24Mucus; Mucous glands; Bursa; Synovial fluid; Arthral fluid; Excreta; Spinal fluid
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    • A61K35/583Snakes; Lizards, e.g. chameleons
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Abstract

The invention discloses a kind of Chinese materia medica preparations and preparation method thereof for treating rheumatism bone disease, belong to technical field of traditional Chinese medicine preparation.Said preparation prescription includes traditional Chinese medicine powder and ingredient A, B, and the traditional Chinese medicine powder is prepared by 58 kinds of crude drugs such as Radix Aconiti, Radix Aconiti Kusnezoffii, Radix Paeoniae Alba, olibanum, myrrh, the root of Chinese clematis, turmeric;The ingredient A includes raw material: capsaicine, borneol, camphor;The ingredient B includes raw material: lard and beeswax.Chinese materia medica preparation of the present invention is proposed by the clinical practice more than 3 years, constantly research and development improvement, for treating rheumatism bone disease with curative for effect, drug effect immediate stability, curative effect is short, quick, feature uneasy to recur after treatment, and it is economical and practical, it is easy to operate, it is easy to carry.

Description

A kind of Chinese materia medica preparation and preparation method thereof for treating rheumatism bone disease
Technical field
The invention belongs to technical field of traditional Chinese medicine preparation more particularly to a kind of Chinese materia medica preparation for treating rheumatism bone disease and its preparations Method.
Background technique
Chinese medicine rheumatism is that human body battalion defends imbalance, and be affected by the cold damp and hot heresy, combined into disease;Or with the passing of time weakened body resistance, interior raw phlegm Turbid, extravasated blood, scorchingly hot, good and evil are mutually fought, and make the qi and blood impatency of channels and collaterals, skin, blood vessels, muscles and bones or even internal organs, are lost in supporting, and are gone out It is existing by limbs joint, myalgia, swelling, it is miserable, numb, weigh, deform, characterized by the symptoms such as stiff and limitation of activity, Even involve a kind of disease general name of internal organs.In short, all infringement joints, muscle, ligament, tendon and synovial membrane etc., are with swelling and pain The disease mainly showed, regardless of its pathogenic factor, category rheumatism scope.
With the continuous development of medical science and technology, many medical matters, researcher are to rheumatism from different directions Systemization research, especially etiology and pathology, pathogenic factor, characteristics of incidence, in terms of achieve breakthrough, mention Many therapeutic method of traditional Chinese and western medicine are gone out.Chinese medicine treatment method therein is because of its Small side effects, and clinical efficacy is significant, development space Greatly, there is a variety of antirheumatic drugs based on single medicine such as Glucosidorum Tripterygll Totorum piece, white peony root's total glycoside in market;With recipe form based at Medicine such as wind-expelling pain-stopping capsule, treating rheumatic ostealgia piece etc.;With various informative medicine puree plaster;And in some hospital-made wind-damp dispelling Medicine preparation etc..Currently, although Chinese medicine is various to the form of therapy of rheumatism, since rheumatism sheet is as a kind of autoimmune Disease belongs to connective tissue disease scope, and the course of disease is long, and the complicated multiplicity of the state of an illness, Yi Fanfu, refractory is more clinical characters.Particularly with The patient of rheumatism acute attack, swelling and pain are almost the clinical concurrent of all patients, and less serious case's functional activity is limited, and limb occurs in severe one Body obstacle.So the present inventor summarize forefathers experiential basis on, in conjunction with this area morbidity's feature, by nearly more than 3 years 2875 patients clinical observation on the therapeutic effect, and deliberate repeatedly improvement, develop the Chinese materia medica preparation for the treatment of rheumatism bone disease.
Summary of the invention
It is an object of the invention to: a kind of Chinese materia medica preparation and preparation method thereof for treating rheumatism bone disease is provided, using 63 tastes Chinese medicine has the function of clearing and activating the channels and collaterals, dispelling wind and eliminating dampness, activating microcirculation and removing stasis medicinal, antalgic, strengthens muscles and bones as effective component, can It realizes quick, thorough Repercusion analgesia, while fully absorbing the external application advantage of traditional black plaster, wax therapy and medicine puree moxibustion and carrying out preparation Improvement can be administered, Transdermal absorption for target tissue, play curative effect of medication, acupuncture point effect, Chinese prescription effect, Western medicine prescription Curative effect, four, which drive carriage, runs neck and neck, and drug effect targets tissue first, and surplus is metabolized using liver kidney, has good effect, poison secondary Act on advantage small, with strong points.
To achieve the goals above, the present invention adopts the following technical scheme:
A kind of Chinese materia medica preparation for treating rheumatism bone disease, including traditional Chinese medicine powder and ingredient A, B, it is characterised in that:
The traditional Chinese medicine powder is prepared by the crude drug of following parts by weight: 10-25 parts of Radix Aconiti, 15-30 parts of Radix Aconiti Kusnezoffii, Radix Paeoniae Alba 30-50 parts, 4-15 parts of olibanum, 6-15 parts of myrrh, 4-45 parts of the root of Chinese clematis, 10-30 parts of turmeric, 4-15 parts of excrementum pteropi, rhizoma corydalis 4- 30 parts, 6-12 parts of asarum, 10-20 parts of ramulus cinnamomi, 10-20 parts of ramulus mori, 4-10 parts of raw ephedra, 6-15 parts of gentianae macrophyllae, 4-10 parts of Rhizoma Et Radix Notopterygii, wood 6-12 parts of melon, 10-20 parts of berba aristolochiae mollissimae, black 4-10 parts of snake, 4-20 parts of cortex acanthopanacis, 4-10 parts of turpentine, 10-20 parts of geranium wilfordii, beauty 8-12 parts of rattan, 9-15 parts of philippine flemingia root, 10-20 parts of lycopodium calvatum, 6-12 parts of erythrina bark, tiger 4-10 parts black, 6-12 parts pointed at both ends, stone 4-10 parts of nanmu rattan, Datura be 4-25 parts sub-, 4-30 parts of tripterygium wilfordii, 10-20 parts of Ramulus euonymi, 4-10 parts of rhizoma dioscoreae nipponicae, Chinese mahonia 4- 10 parts, 4-10 parts of arisacma consanguineum schott, 6-15 parts of peach kernel, 6-12 parts of safflower, 4-30 parts of Caulis Spatholobi, 9-15 parts of Radix Angelicae Sinensis, 6-15 parts of bush, ox 10-25 parts of knee, 4-10 parts of Rhizoma Chuanxiong, Mitsubishi 10-20 parts, 6-12 parts of curcuma zedoary, 10-25 parts of Radix Salviae Miltiorrhizae, 6-12 parts of Fructus Liquidambaris, spina gleditsiae 10-20 parts, 4-10 parts of the seed of cowherb, 4-10 parts of the seed of garden balsam, 4-25 parts of the root of gansui, 10-20 parts of folium sennae, 4-20 parts of the root of fangji, Cortex Eucommiae 4-20 parts, 10-20 parts of the rhizome of davallia, 10-30 parts of Herba Cistanches, 4-10 parts of cloves, 4-10 parts of white pepper, 4-20 parts of rhizoma zingiberis, raw Strychnos nux-vomica It is 9-25 parts sub-;
The ingredient A includes the raw material of following parts by weight: 1.5-2.4 parts of capsaicine, 10-30 parts of borneol, camphor 15-30 Part;
The ingredient B includes the raw material of following parts by weight: 800-1200 parts of lard, 500-650 parts of beeswax.
Preferably, the Chinese materia medica preparation of the treatment rheumatism bone disease, it is characterised in that:
The traditional Chinese medicine powder is prepared by the crude drug of following parts by weight: 25 parts of Radix Aconiti, 25 parts of Radix Aconiti Kusnezoffii, 40 parts of Radix Paeoniae Alba, 15 parts of olibanum, 15 parts of myrrh, 45 parts of the root of Chinese clematis, 30 parts of turmeric, 15 parts of excrementum pteropi, 30 parts of rhizoma corydalis, 10 parts of asarum, ramulus cinnamomi 10 Part, 10 parts of ramulus mori, 10 parts of raw ephedra, 15 parts of gentianae macrophyllae, 10 parts of Rhizoma Et Radix Notopterygii, 10 parts of pawpaw, 10 parts of berba aristolochiae mollissimae, black 10 parts of snake, cortex acanthopanacis 20 parts, 10 parts of turpentine, 10 parts of geranium wilfordii, 10 parts of herba aristolochiae, 15 parts of philippine flemingia root, 10 parts of lycopodium calvatum, 10 parts of erythrina bark, black tiger 10 Part, 10 parts pointed at both ends, 10 parts of Piper wallichii (Miq.) Hand.-Mazz., Datura sub 25 parts, 30 parts of tripterygium wilfordii, 10 parts of Ramulus euonymi, 10 parts of rhizoma dioscoreae nipponicae, ten big function 10 parts of labor, 10 parts of arisacma consanguineum schott, 10 parts of peach kernel, 10 parts of safflower, 30 parts of Caulis Spatholobi, 15 parts of Radix Angelicae Sinensis, 15 parts of bush, 20 parts of radix achyranthis bidentatae, river 10 parts of rhizome of chuanxiong, 10 parts of Mitsubishi, 10 parts of curcuma zedoary, 20 parts of Radix Salviae Miltiorrhizae, 10 parts of Fructus Liquidambaris, 10 parts of spina gleditsiae, 10 parts of the seed of cowherb, the seed of garden balsam 10 Part, 25 parts of the root of gansui, 10 parts of folium sennae, 20 parts of the root of fangji, 20 parts of Cortex Eucommiae, 20 parts of the rhizome of davallia, 20 parts of Herba Cistanches, 10 parts of cloves, white Hu 10 parts of green pepper, 10 parts of rhizoma zingiberis, 25 parts of Semen Strychni;
The ingredient A includes the raw material of following parts by weight: 2.2 parts of capsaicine, 20 parts of borneol, 20 parts of camphor;
The ingredient B includes the raw material of following parts by weight: 1000 parts of lard, 550 parts of beeswax.
Preferably, the Chinese materia medica preparation of the treatment rheumatism bone disease, it is characterised in that:
The traditional Chinese medicine powder is prepared by the crude drug of following parts by weight: 15 parts of Radix Aconiti, 30 parts of Radix Aconiti Kusnezoffii, 45 parts of Radix Paeoniae Alba, 5 parts of olibanum, 10 parts of myrrh, 6 parts of the root of Chinese clematis, 15 parts of turmeric, 6 parts of excrementum pteropi, 6 parts of rhizoma corydalis, 8 parts of asarum, 15 parts of ramulus cinnamomi, ramulus mori 14 parts, 6 parts of raw ephedra, 8 parts of gentianae macrophyllae, 5 parts of Rhizoma Et Radix Notopterygii, 10 parts of pawpaw, 15 parts of berba aristolochiae mollissimae, black 6 parts of snake, 6 parts of cortex acanthopanacis, 6 parts of turpentine, 15 parts of geranium wilfordii, 8 parts of herba aristolochiae, 12 parts of philippine flemingia root, 15 parts of lycopodium calvatum, 8 parts of erythrina bark, 6 parts of black tiger, 8 parts pointed at both ends, Chinese photinia 5 parts of rattan, Datura sub 6 parts, 6 parts of tripterygium wilfordii, 14 parts of Ramulus euonymi, 6 parts of rhizoma dioscoreae nipponicae, 6 parts of Chinese mahonia, 6 parts of arisacma consanguineum schott, peach kernel 6 Part, 8 parts of safflower, 5 parts of Caulis Spatholobi, 12 parts of Radix Angelicae Sinensis, 8 parts of bush, 25 parts of radix achyranthis bidentatae, 6 parts of Rhizoma Chuanxiong, 14 parts of Mitsubishi, 8 parts of curcuma zedoary, Radix Salviae Miltiorrhizae 25 parts, 10 parts of Fructus Liquidambaris, 15 parts of spina gleditsiae, 6 parts of the seed of cowherb, 6 parts impetuous, 6 parts of the root of gansui, 15 parts of folium sennae, 6 parts of the root of fangji, 6 parts of Cortex Eucommiae, 15 parts of the rhizome of davallia, 25 parts of Herba Cistanches, 6 parts of cloves, 6 parts of white pepper, 15 parts of rhizoma zingiberis, 12 parts of Semen Strychni;
The ingredient A includes the raw material of following parts by weight: 2.3 parts of capsaicine, 10 parts of borneol, 25 parts of camphor;
The ingredient B includes the raw material of following parts by weight: 1100 parts of lard, 580 parts of beeswax.
Preferably, the Chinese materia medica preparation of the treatment rheumatism bone disease, it is characterised in that:
The traditional Chinese medicine powder is prepared by the crude drug of following parts by weight: 30 parts of Radix Aconiti, 20 parts of Radix Aconiti Kusnezoffii, 50 parts of Radix Paeoniae Alba, 7 parts of olibanum, 12 parts of myrrh, 8 parts of the root of Chinese clematis, 18 parts of turmeric, 8 parts of excrementum pteropi, 8 parts of rhizoma corydalis, 10 parts of asarum, 20 parts of ramulus cinnamomi, mulberry 17 parts of branch, 8 parts of raw ephedra, 10 parts of gentianae macrophyllae, 7 parts of Rhizoma Et Radix Notopterygii, 12 parts of pawpaw, 18 parts of berba aristolochiae mollissimae, black 8 parts of snake, 8 parts of cortex acanthopanacis, turpentine 8 Part, 20 parts of geranium wilfordii, 12 parts of herba aristolochiae, 15 parts of philippine flemingia root, 20 parts of lycopodium calvatum, 10 parts of erythrina bark, 8 parts of black tiger, pointed at both ends 10 Part, 7 parts of Piper wallichii (Miq.) Hand.-Mazz., Datura sub 8 parts, 8 parts of tripterygium wilfordii, 17 parts of Ramulus euonymi, 8 parts of rhizoma dioscoreae nipponicae, 8 parts of Chinese mahonia, arisacma consanguineum schott 8 Part, 8 parts of peach kernel, 10 parts of safflower, 7 parts of Caulis Spatholobi, 15 parts of Radix Angelicae Sinensis, 10 parts of bush, 15 parts of radix achyranthis bidentatae, 8 parts of Rhizoma Chuanxiong, 17 parts of Mitsubishi, cowherb 10 parts of art, 15 parts of Radix Salviae Miltiorrhizae, 12 parts of Fructus Liquidambaris, 18 parts of spina gleditsiae, 8 parts of the seed of cowherb, impetuous 8 parts, 8 parts of the root of gansui, folium sennae 20 Part, 8 parts of the root of fangji, 8 parts of Cortex Eucommiae, 20 parts of the rhizome of davallia, 30 parts of Herba Cistanches, 8 parts of cloves, 8 parts of white pepper, 20 parts of rhizoma zingiberis, Semen Strychni 15 parts;
The ingredient A includes the raw material of following parts by weight: 2.4 parts of capsaicine, 15 parts of borneol, 30 parts of camphor;
The ingredient B includes the raw material of following parts by weight: 1200 parts of lard, 600 parts of beeswax.
Preferably, the Chinese materia medica preparation of the treatment rheumatism bone disease, it is characterised in that:
The traditional Chinese medicine powder is prepared by the crude drug of following parts by weight: 10 parts of Radix Aconiti, 15 parts of Radix Aconiti Kusnezoffii, 30 parts of Radix Paeoniae Alba, 4 parts of olibanum, 6 parts of myrrh, 4 parts of the root of Chinese clematis, 10 parts of turmeric, 4 parts of excrementum pteropi, 4 parts of rhizoma corydalis, 6 parts of asarum, 10 parts of ramulus cinnamomi, ramulus mori 10 parts, 4 parts of raw ephedra, 6 parts of gentianae macrophyllae, 4 parts of Rhizoma Et Radix Notopterygii, 6 parts of pawpaw, 10 parts of berba aristolochiae mollissimae, black 4 parts of snake, 4 parts of cortex acanthopanacis, 4 parts of turpentine, 10 parts of geranium wilfordii, 8 parts of herba aristolochiae, 9 parts of philippine flemingia root, 10 parts of lycopodium calvatum, 6 parts of erythrina bark, 4 parts of black tiger, 6 parts pointed at both ends, Chinese photinia 4 parts of rattan, Datura sub 4 parts, 4 parts of tripterygium wilfordii, 10 parts of Ramulus euonymi, 4 parts of rhizoma dioscoreae nipponicae, 4 parts of Chinese mahonia, 4 parts of arisacma consanguineum schott, peach kernel 6 Part, 6 parts of safflower, 4 parts of Caulis Spatholobi, 9 parts of Radix Angelicae Sinensis, 6 parts of bush, 10 parts of radix achyranthis bidentatae, 4 parts of Rhizoma Chuanxiong, 10 parts of Mitsubishi, 6 parts of curcuma zedoary, Radix Salviae Miltiorrhizae 10 Part, 6 parts of Fructus Liquidambaris, 10 parts of spina gleditsiae, 4 parts of the seed of cowherb, impetuous 4 parts, 4 parts of the root of gansui, 10 parts of folium sennae, 4 parts of the root of fangji, Cortex Eucommiae 4 parts, 10 parts of the rhizome of davallia, 10 parts of Herba Cistanches, 4 parts of cloves, 4 parts of white pepper, 4 parts of rhizoma zingiberis, 9 parts of Semen Strychni;
The ingredient A includes the raw material of following parts by weight: 2.0 parts of capsaicine, 25 parts of borneol, 15 parts of camphor;
The ingredient B includes the raw material of following parts by weight: 800 parts of lard, 500 parts of beeswax.
Preferably, the Chinese materia medica preparation of the treatment rheumatism bone disease, it is characterised in that:
The traditional Chinese medicine powder is prepared by the crude drug of following parts by weight: 12 parts of Radix Aconiti, 20 parts of Radix Aconiti Kusnezoffii, 35 parts of Radix Paeoniae Alba, 8 parts of olibanum, 12 parts of myrrh, 8 parts of the root of Chinese clematis, 20 parts of turmeric, 8 parts of excrementum pteropi, 8 parts of rhizoma corydalis, 12 parts of asarum, 20 parts of ramulus cinnamomi, mulberry 20 parts of branch, 8 parts of raw ephedra, 12 parts of gentianae macrophyllae, 8 parts of Rhizoma Et Radix Notopterygii, 12 parts of pawpaw, 20 parts of berba aristolochiae mollissimae, black 8 parts of snake, 8 parts of cortex acanthopanacis, turpentine 8 Part, 20 parts of geranium wilfordii, 10 parts of herba aristolochiae, 15 parts of philippine flemingia root, 20 parts of lycopodium calvatum, 12 parts of erythrina bark, 8 parts of black tiger, pointed at both ends 12 Part, 8 parts of Piper wallichii (Miq.) Hand.-Mazz., Datura sub 8 parts, 8 parts of tripterygium wilfordii, 20 parts of Ramulus euonymi, 8 parts of rhizoma dioscoreae nipponicae, 8 parts of Chinese mahonia, arisacma consanguineum schott 8 Part, 15 parts of peach kernel, 12 parts of safflower, 8 parts of Caulis Spatholobi, 15 parts of Radix Angelicae Sinensis, 12 parts of bush, 15 parts of radix achyranthis bidentatae, 8 parts of Rhizoma Chuanxiong, 20 parts of Mitsubishi, cowherb 12 parts of art, 18 parts of Radix Salviae Miltiorrhizae, 12 parts of Fructus Liquidambaris, 20 parts of spina gleditsiae, 8 parts of the seed of cowherb, impetuous 8 parts, 8 parts of the root of gansui, folium sennae 20 Part, 8 parts of the root of fangji, 8 parts of Cortex Eucommiae, 20 parts of the rhizome of davallia, 15 parts of Herba Cistanches, 8 parts of cloves, 8 parts of white pepper, 6 parts of rhizoma zingiberis, Semen Strychni 15 Part;
The ingredient A includes the raw material of following parts by weight: 1.5 parts of capsaicine, 30 parts of borneol, 18 parts of camphor;
The ingredient B includes the raw material of following parts by weight: 900 parts of lard, 650 parts of beeswax.
The Chinese materia medica preparation of above-mentioned treatment rheumatism bone disease is preferably prepared to beeswax cream, and specific preparation process is as follows:
1) crude drug is total to levigation, and crosses 120 meshes, it is spare to obtain traditional Chinese medicine powder;
2) the lard mild fire is heated and refined oil, when oil temperature is increased to 260 DEG C, fry step 1) made from traditional Chinese medicine powder, It then proceedes to stop working when heating stirring turns burned black by Huang to medicinal powder color, natural beeswax is added when temperature is reduced to 100 DEG C, stirs It is uniform to mix fusion;
3) when the medicine oil temperature of step 2) is down to 50 DEG C, borneol, camphor, capsaicine is added, and be evenly stirred until cooling;
4) ointment made of step is packed under liquid condition, obtains the beeswax cream for the treatment of rheumatism bone disease.
The invention also discloses the administrated methods of the Chinese materia medica preparation of above-mentioned treatment rheumatism bone disease, it is characterised in that: will be described After beeswax cream is heated to 35 DEG C, disease sites are smeared, and external application preservative film wraps up, 40 minutes every time.
Pharmacology analysis:
1, compatibility medicinal material effect and effect:
Radix Aconiti: dispelling wind and eliminating dampness, eliminating cold to stop pain, anti-inflammatory and antalgic, blood pressure lowering, anticancer, heart tonifying, anesthesia.
Radix Aconiti Kusnezoffii: wind dehumidifying, dispelling cold analgesia, resolving sputum detumescence are searched.
Raw Radix Paeoniae Alba: liver protection, calmness, analgesia, spasmolysis, anti-bolt, enhancing immune function, resisting stress, wind-damp dispelling.
Olibanum: anti-inflammatory, antitumor, promoting blood circulation and stopping pain exempts from numbness detumescence.
Myrrh: anti-inflammation detumescence, promoting blood circulation and stopping pain, expelling the stasis for the new.
The root of Chinese clematis: antitumor, anti-inflammatory analgesic, antibacterial, dispelling wind and removing obstruction in the meridians are disappeared with walking to alter gram for what one is particularly good at, blood clotting stagnation of the circulation of vital energy Zhu Shiyi It.
Turmeric: anti-inflammatory and antalgic expands blood vessel, dredging collateral.
Excrementum pteropi: anti-inflammatory, promoting blood circulation, antiulcer, regulating qi-flowing for relieving pain detumescence.
Rhizoma corydalis: sedation and analgesia expands blood vessel, is antitumor, blood-activating and qi-promoting analgesic.
Asarum: antipyretic-antalgic, anti-inflammatory heart tonifying, local anaesthesia, expelling wind and clearing away cold are relievingd asthma.
Ramulus cinnamomi: having a sedation and analgesia, anticonvulsant action to nervous system, excited sweat gland secretion, inducing diuresis for removing edema, and wind-damp dispelling is anti- Scorching, expansion blood vessel.
Ramulus mori: reducing blood lipid, anti-oxidant, hypoglycemic, antibacterial anti-inflammatory, dispelling wind and removing obstruction in the meridians.
Chinese ephedra: vasoconstriction, stimulating central nervous system increase the secretion of sweat gland, salivary gland, alleviate smooth muscle spasm, have and relieving asthma The function of sharp water, warming channel and expelling cold energy.
Gentianae macrophyllae: anti-inflammatory, liver protection, blood glucose increasing, immunosupress, decompression, degrading the channel wind-damp dispelling.
Rhizoma Et Radix Notopterygii: antipyretic-antalgic, has stronger expelling cold, eliminating and analgesic effect at anti-inflammatory wind-damp dispelling.
Pawpaw: antitumor, liver protection, anti-inflammatory and antalgic, wind-damp dispelling, strengthening tendons stop contraction.
Berba aristolochiae mollissimae: antitumor, Antiarthritic, treatment rheumatoid arthritis, analgesic, degrading the channel.
Black snake: dispelling, collateral-activating, it is deep search wind, only arthralgia, removing toxic substances.
Cortex acanthopanacis: antitumor, antifatigue reduction whole blood viscosity, anti-inflammation detumescence, dispelling wind and removing obstruction in the meridians.
Turpentine: antalgic and inflammation relieving, wind-damp dispelling.
Geranium wilfordii: antibacterial, anti-inflammatory, antirheumatic, calmness, analgesia, liver protection.
Herba aristolochiae: blood vessel, antithrombotic, swelling and pain relieving, wind-damp dispelling are expanded in decompression.
Philippine flemingia root: wind-damp dispelling, removing toxic substances, activating blood circulation and reducing swelling, strengthening muscles and bones.
Lycopodium calvatum: boosting, diuresis, antipyretic, removing toxic substances, antirheumatic, anti-trioxypurine, invigorating blood circulation analgesia.
Erythrina bark: analgesia, calmness, antibacterial, wind-damp dispelling, degrading the channel, analgesic.
Black tiger: antitumor, antiviral, anti-inflammatory, analgesia, promoting blood circulation, detumescence, wind-damp dispelling.
It is pointed at both ends: antitumor, antirheumatic, swelling and pain relieving.
Piper wallichii (Miq.) Hand.-Mazz.: liver protection, anticoagulant, expansion blood vessel, resisting rheumatoid disease, anti-inflammatory, kidney tonifying, promoting blood circulation and stopping pain.
Datura: dispelling wind and eliminating dampness, narcotic analgesic.
Tripterygium wilfordii: desinsection eliminating inflammation and expelling toxin, immunosupress, antitumor, resisting rheumatoid disease, promoting blood circulation and stopping pain.
Ramulus euonymi: blood vessel, anticoagulant, reducing blood lipid, desinsection, Repercusion analgesia are expanded in the decompression of hypoglycemic heart tonifying.
Rhizoma dioscoreae nipponicae: kobadrin decompression, expands blood vessel, wind-damp dispelling, strengthening muscles and bones at heart tonifying.
Chinese mahonia: wind-damp dispelling, swelling and pain relieving.
Rhizoma arisaematis: eliminating dampness and eliminating phlegm, resolving hard lump, expelling wind and relieving convulsion.
Peach kernel: promoting blood circulation, relax bowel and defecation, antiallergy, analgesia, anticoagulant, antithrombotic.
Safflower: it resists myocardial ischemia, is anticoagulant, is anti-oxidant, expand blood vessel, is antitumor.
Caulis Spatholobi: hematopoiesis, antitumor, antiviral, immunological regulation, anti-inflammatory, analgesia.
Radix Angelicae Sinensis: promoting hematopoiesis function, and antithrombotic improves immune, anti-inflammatory analgesic, antibody Monoclonal, liver protection.
Bush: promoting blood circulation, bone-setting pain stopping.
Radix cyathulae: expelling wind and removing dampness, dredging collateral and promoting blood circulation, decompression, analgesic, diuresis.
Rhizoma Chuanxiong: anti-ischemic sedation and analgesia, is relievingd asthma, liver protection, activating microcirculation and removing stasis medicinal, promoting qi circulation and relieving pain.
Mitsubishi: analgesia, anticoagulation, antitumor.
Curcuma zedoary: promoting the circulation of qi blood-breaking dissipates stasis of blood promoting menstruation, promoting digestion.
Radix Salviae Miltiorrhizae: expand blood vessel, anticoagulant, antibacterial, anti-inflammatory, heart tonifying, blood circulation and channel invigorating, dissolving stasis blood-nourishing, dredging microcirculation, it is antitumor, Analgesic.
Fructus Liquidambaris: dispelling wind and eliminating dampness, swelling and pain relieving.
Spina gleditsiae: detumescence and poison retention, apocenosis, desinsection.
The seed of cowherb: promoting blood circulation and removing obstruction in channels, urination-promoting calculus-eliminating.
It is impetuous: resolving hard lump, blood-breaking detumescence.
The root of gansui: water pouring detumescence, by drink dissipating bind, rush down lower diuresis, antitumor, immunosupress, anti-leukocythemia.
Folium sennae: inducing diuresis for removing edema, row stagnation pain.
Stephania tetrandra: antitumor, anti-inflammatory, analgesia, anti-fibrosis, free radical resisting damage, antibacterial anti-inflammatory, anti-platelet aggregation, Damp-clearing pain-relieving, inducing diuresis for removing edema, modern pharmacological research, Stephania tetrandra are natural calcium channel agent.
Cortex Eucommiae: nourishing liver and kidney, strengthening the bones and muscles, wind-damp dispelling.
The rhizome of davallia: kidney tonifying, promoting blood circulation, hemostasis, continuous wound.
Herba Cistanches: kidney-replenishing, benefiting essence-blood, relax bowel and defecation.
Cloves: middle benefit gas drop is inverse, tonifies the kidney and support yang.
White pepper: antalgic and inflammation relieving, warming spleen and stomach for dispelling cold.
Rhizoma zingiberis: inhibit nervous excitation, expand blood vessel, analgesia, warming spleen and stomach for dispelling cold, inducing sweat and dispelling exogenous evils.
Semen Strychni: activating collaterals and eliminating stagnation, detumescence ding-tong, heat dissipation dispersing blood stasis, numbness relieving and pain relieving, the continuous wound of synthetism, dispelling wind and eliminating dampness.
Capsaicine: it is anti-inflammatory, analgesia, it is antipruritic.
Borneol: sensible, scattered fire, improving eyesight, swelling and pain relieving, anti-inflammatory, myogenic, dredging collateral, transdermal, promotion drug absorption.
Camphor: sensible, cold dispelling, analgesic, antipruritic, desinsection, dampness removing, heart tonifying, boosting, local anaesthesia, transdermal, promotion drug absorption.
Beeswax: solution taking poison and growing muscle due, hemostasis analgesic therapy, detoxification, decocts plaster and priming is transdermal at tonifying middle-Jiao and Qi, promotes drug absorption.
Lard: resolving hard lump, coordinating the drug actions of a prescription, to decoct plaster, priming transdermal, promotes drug absorption.
2) modern pharmacological research is analyzed:
Each drug combines in medicament composing prescription of the present invention, existing anti-inflammatory, detumescence, analgesia, wind-damp dispelling, strengthening the bones and muscles, adjust it is immune, The effects of dredging the channel;There are also resisting stress, anti-osteoporosis, antibacterial, antibacterial, anticoagulant, liver protection, cholagogue, promoting blood circulation, hemostasis, the anti-hearts Myocardial ischemia, it is anti-oxidant the effects of, all medicines organically combines, and complements each other, and plays quick warming spleen and stomach for dispelling cold analgesic, remove rheumatism, is immunized It adjusts, the effect of activating blood circulation and reducing swelling, cures lesion body to reach, damaged tissue repair and the later period state of an illness assist mastery of taking good care of oneself Triple function.
3) action principle:
There is drug of the present invention relatively strong lasting heat penetration to enter effect, can penetrate into synovium of joint position, therefore be conducive to blood Swollen absorption accelerates edema extinction, and can enhance the phagocytosis of reticuloendothelial system, improves metabolism, therefore has anti-inflammatory town Pain acts on.Wherein, beeswax and lard share with anti-corrosion, prevent dry, holding and fixed drug effect, are convenient for docile, stimulate skin capillary Blood vessel dilatation absorbs the drug and humidification;Camphor, borneol, capsaicine have the function of transdermal and surfactant, as medicine Object carrier can promote the effective component of drug, absorb by skin, promote Passive intake effect into subcutaneous, to increase table The effect of skin absorption of drugs.By above-mentioned carrier, drug is made to go directly diseased region, lesion local drug concentration increases, simultaneously After promoting percutaneous drug absorption, along channels and collaterals, inline internal organs, external connection limbs and play therapeutic effect.Furthermore.Spasm can be made slow Solution, there is analgesic effect.
Compared with prior art, the beneficial effects of the present invention are:
1) drug of the present invention is affixed on body surface, can preferably stimulate nerve endings, expands blood vessel by reflecting, and promotes local Blood circulation improves the nutrition of perilesional tissue, reaches detumescence, anti-inflammatory, analgesic purpose.Drug of the present invention is in traditional external application On the basis of recipe, learn from other's strong points to offset one's weaknesses and changed, goes the agent of its pastel flat temperature, high strong using pharmacological property, analgesic effect is obvious, gas The medicine of strong rich raw fragrant guidance, to obtain its prescription, medication number is wide and more, forms big compound, transdermal dense to increase active drug Degree adapts to complicated pathological change, can be saturating due to containing fat-soluble, volatility and irritating drug in many drugs Enter skin to generate anti-inflammatory, relieve pain, remove corruption, myogenic, Thyme Extract, to treat rheumatism and arthritis, relieve pain, strengthen the bone, traumatic injury Deng, make excipient using lard, beeswax cook paste, with anti-corrosion, prevent it is dry, protection affected part, keep lasting medicine, promote drug and process Epidermis generates deep and general action.By channels and collaterals Yu cave and disease sites plaster, drug effect, facilitation are played.It is affixed on affected part thorn Swash nerve endings, by reflection, expands blood vessel, promote local blood circulation, nerve-specific is generated, with Adjusting Mechanism enhancing group It knits and resists strength, reach calm, antiinflammation.
2) drug of the present invention have protection local skin wet soft effect, be by keratoderma space between cells, Follicular wall, sweat gland, sebaceous glands, make Medicated Permeation and absorb, the treatment to wound, skin disease, mucosa infection, have anti-corrosion, The local actions such as anti-inflammatory, analgesic.Meanwhile after drug break-through skin and mucous membrane, entering body circulation by blood vessel or lymphatic vessel can be produced Raw general action.
3) Chinese materia medica preparation of the present invention is in addition to significant in efficacy to rheumatic pain, also to wound swollen pain, osteoarthrosis, gout Also there is certain therapeutic effect.
4) drug of the present invention is by the clinical practice more than 3 years, and constantly research and development improve, facts proved that treatment rheumatism bone disease Curative for effect, drug effect immediate stability, curative effect is short, quick, uneasy to recur after treatment and economical and practical, easy to operate, convenient for taking Band.
5) Chinese medicinal ointment preparation method of the present invention is simple, and understandable, no special installation and instrument, preparation cost is illustrated in technique It is low, using fresh herb is suddenly done, drug effect fully absorbs utilization, while moderate, meets many patients demand.
6) Chinese materia medica preparation of the present invention has fully absorbed the advantages of traditional black plaster, wax therapy and medicine puree moxibustion, the existing black cream of tradition The curative effect of medicine and without its red lead endanger;Not only there is the thermotherapy effect of wax therapy, there are also the drug therapy curative effects for being better than wax therapy;Compare simultaneously Medicine puree moxibustion operation is more succinct convenient, can be recycled, does not pollute, economical and practical.
Specific embodiment
Technical solutions and effects of the present invention is elaborated combined with specific embodiments below, in order to same domain technology The understanding of personnel.It should be noted that following embodiment is only applicable to the explanation and illustration present invention, it is not intended to limit the protection of claim Range.
A kind of Chinese materia medica preparation for treating rheumatism bone disease, is specifically prepared into beeswax putty-type, and specific prescription proportion see the table below 1.
Table 1- treats the drug ratio (g) of the Chinese materia medica preparation of rheumatism bone disease
Crude drug is weighed according to upper table 1, is then prepared into beeswax cream by following processing step:
1) crude drug is total to levigation, and crosses 120 meshes, it is spare to obtain traditional Chinese medicine powder;
2) the lard mild fire is heated and refined oil, when oil temperature is increased to 260 DEG C, fry step 1) made from traditional Chinese medicine powder, It then proceedes to stop working when heating stirring turns burned black by Huang to medicinal powder color, natural beeswax is added when temperature is reduced to 100 DEG C, stirs It is uniform to mix fusion;
3) when the medicine oil temperature of step 2) is down to 50 DEG C, borneol, camphor, capsaicine is added, and be evenly stirred until cooling;
4) ointment made of step is packed under liquid condition, obtains the beeswax cream for the treatment of rheumatism bone disease.
In order to verify the actual efficacy of Chinese materia medica preparation of the present invention, it is explained by clinical comparison test.
1, treatment method
Treatment group and control group are Chinese medicine external preparation, directly act on disease sites, 30 days as one therapeutic course, two groups are used Curative effect is evaluated after three course for the treatment of of medicine.
1.1 treatment groups: after beeswax cream manufactured in embodiment described above is heated to 35 DEG C, smearing disease sites, and It is wrapped up with preservative film, 40 minutes every time, 200 grams every time, once a day;
1.2 control groups:
1) control group 1: wax therapy:, being heated with wax therapy machine by 200 grams of White paraffin, directly acts on affected part at 40 DEG C, and one time one Hour;
2) control group 2: Zushima gaoyao is affixed on affected part after warm softening.
2, criterion of therapeutical effect
According to the Standards for Diagnosis and Curative Effect of Chinese Medical Symptom that State Administration of Traditional Chinese Medicine's on June 28th, 1994 promulgates, according to wind The standard of wet osteopathy is determined.
3, treatment results
3.1 research treatment groups totally 822, total effective rate is up to 95.1%;With 450 control groups (wax therapy 210, girald daphne bark 240, plaster) it compares, difference has very significant meaning, is specifically shown in the following table 2.
Table 2- treatment group and control group total effects
Grouping It cures (example) It improves (example) (example) in vain Total effective rate (%)
Treatment group 550 232 40 95.1
Control group 1 47 122 41 80.5
Control group 2 52 154 44 82.4
3.2 rheumatism bone disease Syndrome Differentiation of Traditional Chinese Medicine and therapeutic effect relationship, are specifically shown in the following table 3.
Table 3- rheumatism bone disease Syndrome Differentiation of Traditional Chinese Medicine and therapeutic effect relationship
4, it discusses
Drug combines existing anti-inflammatory, detumescence, analgesia, wind-damp dispelling in pharmaceutical formulation of the present invention, strengthening the bones and muscles, adjust it is immune, The effects of dredging the channel.Simultaneously there are also resisting stress, anti-osteoporosis, antibacterial, antibacterial, anticoagulant, liver protection, cholagogue, promoting blood circulation, hemostasis, Resist myocardial ischemia, it is anti-oxidant the effects of, all medicines share can play quick warming spleen and stomach for dispelling cold analgesic, remove rheumatism, immunological regulation, promoting blood circulation Reduce swelling purpose, cure lesion body to reach, damaged tissue repair and later period state of an illness auxiliary are taken good care of oneself the triple function of mastery. It is clinically used for treatment rheumatic arthritis, rheumatoid arthritis, ankylosing spondylitis, synovitis, urarthritis and regression Property the acute attacks such as osteoarthritis when caused swelling and pain swollen and ache apparent disease particular for synovium of joint through clinical observation in 3 years It is significant in efficacy.There is more satisfied effect to the swelling and pain of other muscle, ligament, tendon and wound.

Claims (8)

1. a kind of Chinese materia medica preparation for treating rheumatism bone disease, including traditional Chinese medicine powder and ingredient A, B, it is characterised in that:
The traditional Chinese medicine powder is prepared by the crude drug of following parts by weight: 10-25 parts of Radix Aconiti, 15-30 parts of Radix Aconiti Kusnezoffii, Radix Paeoniae Alba 30- 50 parts, 4-15 parts of olibanum, 6-15 parts of myrrh, 4-45 parts of the root of Chinese clematis, 10-30 parts of turmeric, 4-15 parts of excrementum pteropi, rhizoma corydalis 4-30 Part, 6-12 parts of asarum, 10-20 parts of ramulus cinnamomi, 10-20 parts of ramulus mori, 4-10 parts of raw ephedra, 6-15 parts of gentianae macrophyllae, 4-10 parts of Rhizoma Et Radix Notopterygii, pawpaw 6-12 parts, 10-20 parts of berba aristolochiae mollissimae, black 4-10 parts of snake, 4-20 parts of cortex acanthopanacis, 4-10 parts of turpentine, 10-20 parts of geranium wilfordii, herba aristolochiae 8-12 parts, 9-15 parts of philippine flemingia root, 10-20 parts of lycopodium calvatum, 6-12 parts of erythrina bark, tiger 4-10 parts black, 6-12 parts pointed at both ends, Chinese photinia 4-10 parts of rattan, Datura be 4-25 parts sub-, 4-30 parts of tripterygium wilfordii, 10-20 parts of Ramulus euonymi, 4-10 parts of rhizoma dioscoreae nipponicae, Chinese mahonia 4-10 Part, 4-10 parts of arisacma consanguineum schott, 6-15 parts of peach kernel, 6-12 parts of safflower, 4-30 parts of Caulis Spatholobi, 9-15 parts of Radix Angelicae Sinensis, 6-15 parts of bush, radix achyranthis bidentatae 10-25 parts, 4-10 parts of Rhizoma Chuanxiong, Mitsubishi 10-20 parts, 6-12 parts of curcuma zedoary, 10-25 parts of Radix Salviae Miltiorrhizae, 6-12 parts of Fructus Liquidambaris, spina gleditsiae 10- 20 parts, 4-10 parts of the seed of cowherb, 4-10 parts of the seed of garden balsam, 4-25 parts of the root of gansui, 10-20 parts of folium sennae, 4-20 parts of the root of fangji, Cortex Eucommiae 4-20 Part, 10-20 parts of the rhizome of davallia, 10-30 parts of Herba Cistanches, 4-10 parts of cloves, 4-10 parts of white pepper, 4-20 parts of rhizoma zingiberis, Semen Strychni 9- 25 parts;
The ingredient A includes the raw material of following parts by weight: 1.5-2.4 parts of capsaicine, 10-30 parts of borneol, 15-30 parts of camphor;
The ingredient B includes the raw material of following parts by weight: 800-1200 parts of lard, 500-650 parts of beeswax.
2. the Chinese materia medica preparation for the treatment of rheumatism bone disease as described in claim 1, it is characterised in that:
The traditional Chinese medicine powder is prepared by the crude drug of following parts by weight: 25 parts of Radix Aconiti, 25 parts of Radix Aconiti Kusnezoffii, 40 parts of Radix Paeoniae Alba, olibanum 15 parts, 15 parts of myrrh, 45 parts of the root of Chinese clematis, 30 parts of turmeric, 15 parts of excrementum pteropi, 30 parts of rhizoma corydalis, 10 parts of asarum, 10 parts of ramulus cinnamomi, mulberry 10 parts of branch, 10 parts of raw ephedra, 15 parts of gentianae macrophyllae, 10 parts of Rhizoma Et Radix Notopterygii, 10 parts of pawpaw, 10 parts of berba aristolochiae mollissimae, black 10 parts of snake, 20 parts of cortex acanthopanacis, 10 parts of turpentine, 10 parts of geranium wilfordii, 10 parts of herba aristolochiae, 15 parts of philippine flemingia root, 10 parts of lycopodium calvatum, 10 parts of erythrina bark, 10 parts of black tiger, two 10 parts of head point, 10 parts of Piper wallichii (Miq.) Hand.-Mazz., Datura sub 25 parts, 30 parts of tripterygium wilfordii, 10 parts of Ramulus euonymi, 10 parts of rhizoma dioscoreae nipponicae, Chinese mahonia 10 Part, 10 parts of arisacma consanguineum schott, 10 parts of peach kernel, 10 parts of safflower, 30 parts of Caulis Spatholobi, 15 parts of Radix Angelicae Sinensis, 15 parts of bush, 20 parts of radix achyranthis bidentatae, Rhizoma Chuanxiong 10 Part, 10 parts of Mitsubishi, 10 parts of curcuma zedoary, 20 parts of Radix Salviae Miltiorrhizae, 10 parts of Fructus Liquidambaris, 10 parts of spina gleditsiae, 10 parts of the seed of cowherb, it is 10 parts impetuous, 25 parts of the root of gansui, 10 parts of folium sennae, 20 parts of the root of fangji, 20 parts of Cortex Eucommiae, 20 parts of the rhizome of davallia, 20 parts of Herba Cistanches, 10 parts of cloves, white pepper 10 Part, 10 parts of rhizoma zingiberis, 25 parts of Semen Strychni;
The ingredient A includes the raw material of following parts by weight: 2.2 parts of capsaicine, 20 parts of borneol, 20 parts of camphor;
The ingredient B includes the raw material of following parts by weight: 1000 parts of lard, 550 parts of beeswax.
3. the Chinese materia medica preparation for the treatment of rheumatism bone disease as described in claim 1, it is characterised in that:
The traditional Chinese medicine powder is prepared by the crude drug of following parts by weight: 15 parts of Radix Aconiti, 30 parts of Radix Aconiti Kusnezoffii, 45 parts of Radix Paeoniae Alba, olibanum 5 Part, 10 parts of myrrh, 6 parts of the root of Chinese clematis, 15 parts of turmeric, 6 parts of excrementum pteropi, 6 parts of rhizoma corydalis, 8 parts of asarum, 15 parts of ramulus cinnamomi, 14 parts of ramulus mori, 6 parts of raw ephedra, 8 parts of gentianae macrophyllae, 5 parts of Rhizoma Et Radix Notopterygii, 10 parts of pawpaw, 15 parts of berba aristolochiae mollissimae, black 6 parts of snake, 6 parts of cortex acanthopanacis, 6 parts of turpentine, old stork Careless 15 parts, 8 parts of herba aristolochiae, 12 parts of philippine flemingia root, 15 parts of lycopodium calvatum, 8 parts of erythrina bark, 6 parts of black tiger, 8 parts pointed at both ends, Piper wallichii (Miq.) Hand.-Mazz. 5 Part, Datura son 6 parts, 6 parts of tripterygium wilfordii, 14 parts of Ramulus euonymi, 6 parts of rhizoma dioscoreae nipponicae, 6 parts of Chinese mahonia, 6 parts of arisacma consanguineum schott, 6 parts of peach kernel, 8 parts of safflower, 5 parts of Caulis Spatholobi, 12 parts of Radix Angelicae Sinensis, 8 parts of bush, 25 parts of radix achyranthis bidentatae, 6 parts of Rhizoma Chuanxiong, 14 parts of Mitsubishi, 8 parts of curcuma zedoary, Radix Salviae Miltiorrhizae 25 Part, 10 parts of Fructus Liquidambaris, 15 parts of spina gleditsiae, 6 parts of the seed of cowherb, 6 parts impetuous, 6 parts of the root of gansui, 15 parts of folium sennae, 6 parts of the root of fangji, Du Secondary 6 parts, 15 parts of the rhizome of davallia, 25 parts of Herba Cistanches, 6 parts of cloves, 6 parts of white pepper, 15 parts of rhizoma zingiberis, 12 parts of Semen Strychni;
The ingredient A includes the raw material of following parts by weight: 2.3 parts of capsaicine, 10 parts of borneol, 25 parts of camphor;
The ingredient B includes the raw material of following parts by weight: 1100 parts of lard, 580 parts of beeswax.
4. the Chinese materia medica preparation for the treatment of rheumatism bone disease as described in claim 1, it is characterised in that:
The traditional Chinese medicine powder is prepared by the crude drug of following parts by weight: 30 parts of Radix Aconiti, 20 parts of Radix Aconiti Kusnezoffii, 50 parts of Radix Paeoniae Alba, olibanum 7 Part, 12 parts of myrrh, 8 parts of the root of Chinese clematis, 18 parts of turmeric, 8 parts of excrementum pteropi, 8 parts of rhizoma corydalis, 10 parts of asarum, 20 parts of ramulus cinnamomi, ramulus mori 17 Part, 8 parts of raw ephedra, 10 parts of gentianae macrophyllae, 7 parts of Rhizoma Et Radix Notopterygii, 12 parts of pawpaw, 18 parts of berba aristolochiae mollissimae, black 8 parts of snake, 8 parts of cortex acanthopanacis, 8 parts of turpentine, 20 parts of geranium wilfordii, 12 parts of herba aristolochiae, 15 parts of philippine flemingia root, 20 parts of lycopodium calvatum, 10 parts of erythrina bark, 8 parts of black tiger, it is 10 parts pointed at both ends, 7 parts of Piper wallichii (Miq.) Hand.-Mazz., Datura sub 8 parts, 8 parts of tripterygium wilfordii, 17 parts of Ramulus euonymi, 8 parts of rhizoma dioscoreae nipponicae, 8 parts of Chinese mahonia, 8 parts of arisacma consanguineum schott, peach 8 parts of benevolence, 10 parts of safflower, 7 parts of Caulis Spatholobi, 15 parts of Radix Angelicae Sinensis, 10 parts of bush, 15 parts of radix achyranthis bidentatae, 8 parts of Rhizoma Chuanxiong, 17 parts of Mitsubishi, curcuma zedoary 10 Part, 8 parts impetuous, 8 parts of the root of gansui, 20 parts of folium sennae, is prevented 15 parts of Radix Salviae Miltiorrhizae, 12 parts of Fructus Liquidambaris, 18 parts of spina gleditsiae, 8 parts of the seed of cowherb Oneself 8 parts, 8 parts of Cortex Eucommiae, 20 parts of the rhizome of davallia, 30 parts of Herba Cistanches, 8 parts of cloves, 8 parts of white pepper, 20 parts of rhizoma zingiberis, 15 parts of Semen Strychni;
The ingredient A includes the raw material of following parts by weight: 2.4 parts of capsaicine, 15 parts of borneol, 30 parts of camphor;
The ingredient B includes the raw material of following parts by weight: 1200 parts of lard, 600 parts of beeswax.
5. the Chinese materia medica preparation for the treatment of rheumatism bone disease as described in claim 1, it is characterised in that:
The traditional Chinese medicine powder is prepared by the crude drug of following parts by weight: 10 parts of Radix Aconiti, 15 parts of Radix Aconiti Kusnezoffii, 30 parts of Radix Paeoniae Alba, olibanum 4 Part, 6 parts of myrrh, 4 parts of the root of Chinese clematis, 10 parts of turmeric, 4 parts of excrementum pteropi, 4 parts of rhizoma corydalis, 6 parts of asarum, 10 parts of ramulus cinnamomi, 10 parts of ramulus mori, 4 parts of raw ephedra, 6 parts of gentianae macrophyllae, 4 parts of Rhizoma Et Radix Notopterygii, 6 parts of pawpaw, 10 parts of berba aristolochiae mollissimae, black 4 parts of snake, 4 parts of cortex acanthopanacis, 4 parts of turpentine, geranium wilfordii 10 parts, 8 parts of herba aristolochiae, 9 parts of philippine flemingia root, 10 parts of lycopodium calvatum, 6 parts of erythrina bark, 4 parts of black tiger, 6 parts pointed at both ends, 4 parts of Piper wallichii (Miq.) Hand.-Mazz., Datura son 4 parts, 4 parts of tripterygium wilfordii, 10 parts of Ramulus euonymi, 4 parts of rhizoma dioscoreae nipponicae, 4 parts of Chinese mahonia, 4 parts of arisacma consanguineum schott, 6 parts of peach kernel, safflower 6 parts, 4 parts of Caulis Spatholobi, 9 parts of Radix Angelicae Sinensis, 6 parts of bush, 10 parts of radix achyranthis bidentatae, 4 parts of Rhizoma Chuanxiong, 10 parts of Mitsubishi, 6 parts of curcuma zedoary, 10 parts of Radix Salviae Miltiorrhizae, Lu Lu 6 parts logical, 10 parts of spina gleditsiae, 4 parts of the seed of cowherb, impetuous 4 parts, 4 parts of the root of gansui, 10 parts of folium sennae, 4 parts of the root of fangji, 4 parts of Cortex Eucommiae, bone Broken benefit 10 parts, 10 parts of Herba Cistanches, 4 parts of cloves, 4 parts of white pepper, 4 parts of rhizoma zingiberis, 9 parts of Semen Strychni;
The ingredient A includes the raw material of following parts by weight: 2.0 parts of capsaicine, 25 parts of borneol, 15 parts of camphor;
The ingredient B includes the raw material of following parts by weight: 800 parts of lard, 500 parts of beeswax.
6. the Chinese materia medica preparation for the treatment of rheumatism bone disease as described in claim 1, it is characterised in that:
The traditional Chinese medicine powder is prepared by the crude drug of following parts by weight: 12 parts of Radix Aconiti, 20 parts of Radix Aconiti Kusnezoffii, 35 parts of Radix Paeoniae Alba, olibanum 8 Part, 12 parts of myrrh, 8 parts of the root of Chinese clematis, 20 parts of turmeric, 8 parts of excrementum pteropi, 8 parts of rhizoma corydalis, 12 parts of asarum, 20 parts of ramulus cinnamomi, ramulus mori 20 Part, 8 parts of raw ephedra, 12 parts of gentianae macrophyllae, 8 parts of Rhizoma Et Radix Notopterygii, 12 parts of pawpaw, 20 parts of berba aristolochiae mollissimae, black 8 parts of snake, 8 parts of cortex acanthopanacis, 8 parts of turpentine, 20 parts of geranium wilfordii, 10 parts of herba aristolochiae, 15 parts of philippine flemingia root, 20 parts of lycopodium calvatum, 12 parts of erythrina bark, 8 parts of black tiger, it is 12 parts pointed at both ends, 8 parts of Piper wallichii (Miq.) Hand.-Mazz., Datura sub 8 parts, 8 parts of tripterygium wilfordii, 20 parts of Ramulus euonymi, 8 parts of rhizoma dioscoreae nipponicae, 8 parts of Chinese mahonia, 8 parts of arisacma consanguineum schott, peach 15 parts of benevolence, 12 parts of safflower, 8 parts of Caulis Spatholobi, 15 parts of Radix Angelicae Sinensis, 12 parts of bush, 15 parts of radix achyranthis bidentatae, 8 parts of Rhizoma Chuanxiong, 20 parts of Mitsubishi, curcuma zedoary 12 Part, 8 parts impetuous, 8 parts of the root of gansui, 20 parts of folium sennae, is prevented 18 parts of Radix Salviae Miltiorrhizae, 12 parts of Fructus Liquidambaris, 20 parts of spina gleditsiae, 8 parts of the seed of cowherb Oneself 8 parts, 8 parts of Cortex Eucommiae, 20 parts of the rhizome of davallia, 15 parts of Herba Cistanches, 8 parts of cloves, 8 parts of white pepper, 6 parts of rhizoma zingiberis, 15 parts of Semen Strychni;
The ingredient A includes the raw material of following parts by weight: 1.5 parts of capsaicine, 30 parts of borneol, 18 parts of camphor;
The ingredient B includes the raw material of following parts by weight: 900 parts of lard, 650 parts of beeswax.
7. the Chinese materia medica preparation for the treatment of rheumatism bone disease as claimed in any one of claims 1 to 6, it is characterised in that: by the treatment The Chinese materia medica preparation of rheumatism bone disease is prepared into beeswax cream, and specific step of preparation process is as follows:
1) crude drug is total to levigation, and crosses 120 meshes, it is spare to obtain traditional Chinese medicine powder;
2) the lard mild fire is heated and refined oil, when oil temperature is increased to 260 DEG C, fry step 1) made from traditional Chinese medicine powder, then Continue to stop working when heating stirring turns burned black by Huang to medicinal powder color, natural beeswax is added when temperature is reduced to 100 DEG C, stirring is melted It closes uniform;
3) when the medicine oil temperature of step 2) is down to 50 DEG C, borneol, camphor, capsaicine is added, and be evenly stirred until cooling;
4) ointment made of step is packed under liquid condition, obtains the beeswax cream for the treatment of rheumatism bone disease.
8. a kind of administrated method for the Chinese materia medica preparation for treating rheumatism bone disease, it is characterised in that: the beeswax cream is heated to 35 DEG C Afterwards, disease sites are smeared, and external application preservative film wraps up, 40 minutes every time.
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110170034A (en) * 2019-04-23 2019-08-27 王学素 A kind of rheumatism bone disease medicine and preparation method thereof

Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1198337A (en) * 1997-05-06 1998-11-11 刁金山 Capsule for curing rheumatism
CN1213553A (en) * 1998-10-28 1999-04-14 刘方明 Gu'anning ointment for treating hyperosteogeny and its prepn. method
CN1433782A (en) * 2002-01-22 2003-08-06 康长生 Formula of external medicine for treating rheumatism numbness pain and preparation process thereof
CN1742830A (en) * 2005-09-21 2006-03-08 灵宝市商业医院 Pain-treating chinese medicine
CN1839968A (en) * 2006-01-25 2006-10-04 段建敏 Medicine for hyperplasia scar and preparing method thereof
CN100998838A (en) * 2006-12-29 2007-07-18 张秋霞 Chinese medicine for relaxing muscles and tendons to promote blood circulation preparation method thereof
CN102028921A (en) * 2011-01-06 2011-04-27 胡洪昌 Externally applied plaster prepared from pure traditional Chinese medicines and preparation method thereof
CN102188673A (en) * 2010-03-17 2011-09-21 赵贵凤 Plaster for promoting muscles and bones, and preparation and application thereof
CN104940776A (en) * 2015-06-04 2015-09-30 张晓艳 Traditional Chinese medicine composition for mud-moxibustion rheumatic diseases
CN107174623A (en) * 2017-06-09 2017-09-19 孙德成 Treat the plaster of rheumatism bone disease
CN107551004A (en) * 2017-09-30 2018-01-09 徐斌 A kind of Externally applied Chinese medicine wax moxibustion for treating cervical spondylopathy
CN107582781A (en) * 2017-09-30 2018-01-16 徐斌 A kind of Externally applied Chinese medicine wax moxibustion for treating lumbar vertebra disease
CN108066561A (en) * 2017-12-20 2018-05-25 赵鑫 A kind of plaster for treating treating rheumatic ostealgia
CN108653708A (en) * 2018-08-14 2018-10-16 周福运 A kind of wax therapy that treating rheumatism bone disease Tibetan medicine wax mud
CN108926616A (en) * 2018-06-29 2018-12-04 江苏龙润药业有限公司 A kind of externally applied Chinese medicine wax moxibustion for treating rheumatism

Patent Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1198337A (en) * 1997-05-06 1998-11-11 刁金山 Capsule for curing rheumatism
CN1213553A (en) * 1998-10-28 1999-04-14 刘方明 Gu'anning ointment for treating hyperosteogeny and its prepn. method
CN1433782A (en) * 2002-01-22 2003-08-06 康长生 Formula of external medicine for treating rheumatism numbness pain and preparation process thereof
CN1742830A (en) * 2005-09-21 2006-03-08 灵宝市商业医院 Pain-treating chinese medicine
CN1839968A (en) * 2006-01-25 2006-10-04 段建敏 Medicine for hyperplasia scar and preparing method thereof
CN100998838A (en) * 2006-12-29 2007-07-18 张秋霞 Chinese medicine for relaxing muscles and tendons to promote blood circulation preparation method thereof
CN102188673A (en) * 2010-03-17 2011-09-21 赵贵凤 Plaster for promoting muscles and bones, and preparation and application thereof
CN102028921A (en) * 2011-01-06 2011-04-27 胡洪昌 Externally applied plaster prepared from pure traditional Chinese medicines and preparation method thereof
CN104940776A (en) * 2015-06-04 2015-09-30 张晓艳 Traditional Chinese medicine composition for mud-moxibustion rheumatic diseases
CN107174623A (en) * 2017-06-09 2017-09-19 孙德成 Treat the plaster of rheumatism bone disease
CN107551004A (en) * 2017-09-30 2018-01-09 徐斌 A kind of Externally applied Chinese medicine wax moxibustion for treating cervical spondylopathy
CN107582781A (en) * 2017-09-30 2018-01-16 徐斌 A kind of Externally applied Chinese medicine wax moxibustion for treating lumbar vertebra disease
CN108066561A (en) * 2017-12-20 2018-05-25 赵鑫 A kind of plaster for treating treating rheumatic ostealgia
CN108926616A (en) * 2018-06-29 2018-12-04 江苏龙润药业有限公司 A kind of externally applied Chinese medicine wax moxibustion for treating rheumatism
CN108653708A (en) * 2018-08-14 2018-10-16 周福运 A kind of wax therapy that treating rheumatism bone disease Tibetan medicine wax mud

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
孙昌云: "伤损止痛膏制作工艺", 《中医药临床杂志》 *
李经选等: "类风湿性关节炎的中药外治法", 《新疆中医药》 *
王华杰等: "骨刺膏治疗痹证型颈椎病76例疗效观察", 《中国民间疗法》 *
王靖博等: "万痛灵膏药的制备方法", 《河南中医》 *
韩冰: "《中国分科食疗大全》", 30 November 1995, 天津大学出版社 *
黄桂忠等: "中药热敷包配合好及施(温感)治疗慢性骨关节肌肉疼痛60例", 《新中医》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110170034A (en) * 2019-04-23 2019-08-27 王学素 A kind of rheumatism bone disease medicine and preparation method thereof

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