CN109363187A - It is a kind of to adjust immune, antifatigue and relax bowel and defecation composition and preparation method thereof - Google Patents
It is a kind of to adjust immune, antifatigue and relax bowel and defecation composition and preparation method thereof Download PDFInfo
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- CN109363187A CN109363187A CN201811076320.XA CN201811076320A CN109363187A CN 109363187 A CN109363187 A CN 109363187A CN 201811076320 A CN201811076320 A CN 201811076320A CN 109363187 A CN109363187 A CN 109363187A
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/733—Fructosans, e.g. inulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/168—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
Immune, antifatigue and relax bowel and defecation composition and preparation method thereof is adjusted the invention discloses a kind of, it includes the ingredients of following parts by weight: 300-800 parts of semen sojae atricolor albumen, 50-250 parts of soybean protein, 50-250 parts of pea protein, 10-200 parts of walnut protein, 50-250 parts of oligofructose；Preparation method mainly uses wet spray granulating technology, combines dry mixing process when necessary.Composition provided by the present invention passes through the reasonable formula and cooperate with shared of various composition, and by nourishing the five internal organs, kidney tonifying marrow facilitating, tranquilize the mind and promote the intelligence adjusts intestinal flora balance, has the function that adjust immune, antifatigue and relax bowel and defecation；Its raw material edible safety, is easy to absorb, it is demonstrated experimentally that composition provided by the present invention is saving excellent effect immune, in antifatigue and relax bowel and defecation, has highly important actual promotional value.
Description
Technical field
The invention belongs to drugs and field of health care products, and in particular to a kind of to adjust immune, antifatigue and relax bowel and defecation group
Close object and preparation method thereof.
Background technique
In the life of modern, " fatigue " has become a kind of universal sub-health state, becomes the " stealthy of health of people
Killer " is classified as one of the principal element that 21 century endangers human health by the World Health Organization.
Chinese medicine thinks that the interpretation of the cause, onset and process of an illness of fatigue mainly has qi and blood not normal and the functional disturbance of the five internal organs (especially liver, spleen and kidney).It is tired
Labor generation generally entails that human immunologic function reduces, and if things go on like this easily causes other physiological disorders, seriously annoyings people's
Life.
Immunity and antifatigue product are adjusted mainly using lactalbumin as raw material currently, having in the market, and temporary solution is not controlled
This, and less effective.Therefore, urgent need researchs and develops a kind of can fundamentally adjust and is immunized and antifatigue composition.
China's traditional medicine thinks that black-food has the function of consolidating righting, delays senescence and keep fit and healthy, " macrobiosis
Secret record " it records, " taking black soybean, make us long skin, beneficial color, replenishing essence marrow, if strength, qi-restoratives can be eaten, mystery side "；It is bright
It is sayed in Compendium of Material Medica, " it is light to make us body for long term usage；It harnesses the river, dissipate-swelling, lower gas, wind-heat processed and promoting blood circulation and detoxication, so-called People of the same tastes and habits like to be together
".Walnut is a kind of nut full of nutrition, can be with containing there are many unsaturated fatty acid, walnut phosphatide and trace element zinc
It enhances human immunity and disease resistance；Oligofructose is natural prebiotics, can effectively improve chronic fatigue syndrome
Gastrointestinal function imbalance, play a significant role in gastrointestinal tract and the two-way response of central nervous system.In addition, " legendary god of farming's book on Chinese herbal medicine
Through " record, ginseng is top grade, has that " main tonifying five zang organs, soothe the nerves, determine soul, stop palpitate with fear, improving eyesight, happy intelligence development, and long term usage has gently
Body macrobiosis " and other effects.
Up to the present, there is not yet related semen sojae atricolor albumen, soybean protein, pea protein, walnut protein, oligofructose etc.
Combine in the report for adjusting the application in immune, antifatigue and relax bowel and defecation.
Summary of the invention
The purpose of the present invention is overcome the deficiencies of the prior art and provide it is a kind of can nourish the five internal organs, tranquilize the mind and promote the intelligence adjusts enteron aisle
Colony balance, to adjust immune, antifatigue and energy relax bowel and defecation composition.
It is a further object of the present invention to provide the preparation methods of the composition.
It is yet another object of the invention to provide the applications of the composition.
It is provided by the invention it is a kind of adjust immune, antifatigue and relax bowel and defecation composition, comprising following parts by weight at
Point: it is 300-800 parts of semen sojae atricolor albumen, 50-250 parts of soybean protein, 50-250 parts of pea protein, 10-200 parts of walnut protein, oligomeric
50-250 parts of fructose.
Preferably, provided by the present invention to adjust immune, antifatigue and relax bowel and defecation composition, further includes: ginseng mentions
Take one of 0.1-60 parts of object, inulin 1.5-250,0.2-120 parts of nut fruit vegetable powder and 0.5-200 parts of sweetener or a variety of.
It is further preferred that provided by the invention adjust immune, antifatigue and relax bowel and defecation composition, comprising following heavy
The ingredient of amount part: 350-500 parts of semen sojae atricolor albumen, 100-200 parts of soybean protein, 100-200 parts of pea protein, walnut protein 50-
100 parts, 80-180 parts of oligofructose, 10-60 parts of ginseng extract, 100-200 parts of inulin, 50-100 parts of nut fruit vegetable powder, sweet tea
10-50 parts of taste agent.
It is provided by the present invention to adjust in immune, the antifatigue and composition of relax bowel and defecation:
In the semen sojae atricolor albumen, the content of protein is no less than 12wt%, and the content of dietary fiber is no less than 6wt%.
Preferably, the semen sojae atricolor albumen is that semen sojae atricolor through physical squeezing oil removing, high temperature extrusion extruding and is ground,
In, the content of grease is 4.5-10wt%, and the content of protein is 35-50wt%, and the content of dietary fiber is 15-
18.5wt%.
In the soybean protein, the content of protein is no less than 40wt%, preferably not less than 80wt%.
In the pea protein, the content of protein is no less than 70wt%.
The walnut protein is made of the walnut cakes after physical squeezing oil removing, wherein the content of protein is 25-
60wt% preferably smashes it through the particle of 40-60 mesh.
In the oligofructose, oligofructose content is no less than 55wt%, preferably not less than 90wt%.
The ginseng extract is the powdery or paste extract of the dry root of plant ginseng, wherein ginsenoside contains
Amount is 1-20wt%.
The inulin is the natural inulin that the fructose degree of polymerization is 10-35.
The sweetener includes: 0-22 parts of antierythrite, 0-15 parts of xylitol, 0-12 parts of crystal diabetin, steviol glycoside 0-
0.5 part and one of Fructus Momordicae fructoside 0-0.5 parts or a variety of.
The nut fruit vegetable powder includes bar denier wood powder, black sesame powder, pumpkin seed powder, blueberry powder, cherry powder, apple powder, west
One of orchid powder and spinach powder are a variety of.
The preparation method of the present invention provides above-mentioned adjustings immune, antifatigue and relax bowel and defecation composition,
As protein content≤50wt% of the composition, comprising the following steps:
S1, each ingredient is mixed with sterile water according to the ratio, obtains the mixed liquor that concentration is 20-60wt%；
S2, mixed liquor is sterilized into 1-15min at 80-120 DEG C；
S3, by the mixed liquor after sterilization homogeneous 1-2 times at 40-50 DEG C, 20-45Mpa；
S4, finally by the mixed liquor after homogeneous main air blower temperature is 160-190 DEG C, exhaust outlet temperature is 65-90 DEG C
Under conditions of be spray-dried, be granulated, cross 30 mesh vibrating screens to get；
When the protein content of the composition is greater than 50wt%, comprising the following steps:
S1, it will be mixed according to the ratio with sterile water except each ingredient of soybean protein and pea protein, obtaining concentration is 20-
The base-material mixed liquor of 60wt%；
S2, base-material mixed liquor is sterilized into 1-15min at 80-120 DEG C；
S3, by the base-material mixed liquor after sterilization homogeneous 1-2 times at 40-50 DEG C, 20-45Mpa；
S4, then by the base-material mixed liquor after homogeneous main air blower temperature is 160-190 DEG C, exhaust outlet temperature is 65-90
It is spray-dried, is granulated under conditions of DEG C, cross 30 mesh vibrating screens to get base-material；
S5, finally by soybean protein, pea protein and base-material according to the ratio it is dry-mixed uniformly to get.
The present invention also provides above-mentioned compositions or above-mentioned preparation method to adjust immune, antifatigue and relax bowel and defecation in preparation
Food, the application in drug or health care product.
Immune, antifatigue and relax bowel and defecation the composition of adjusting of the invention can increase in production according to corresponding ratio
Or reduce, as large-scale production can by kilogram or as unit of ton, small-scale production can also in grams, and weight can be with
It increases or reduces, but the raw material weight proportioning of soup processed constant rate between each composition.
The present invention adjusts immune, antifatigue and relax bowel and defecation composition and has the advantages that
(1) provided by the present invention to adjust immune, antifatigue and relax bowel and defecation composition with semen sojae atricolor albumen, soybean egg
White, pea protein, walnut protein, oligofructose are main component, make various composition reasonable formula, cooperate with shared, pass through nourishing
The five internal organs, kidney tonifying marrow facilitating, tranquilize the mind and promote the intelligence adjust intestinal flora balance, have the function that adjust immune, antifatigue and relax bowel and defecation,
It is applicable to the sub-health population of big pressure, fatiguability and tired mind；
(2) adjusting provided by the present invention semen sojae atricolor albumen immune, in the antifatigue and composition of relax bowel and defecation, soybean egg
White, pea protein, walnut protein are dual-purpose of drug and food, and securely and reliably, and semen sojae atricolor albumen and walnut protein are respectively semen sojae atricolor and core
By-product of the peach after physics extracts oil improves the comprehensive utilization ratio and added value of product of semen sojae atricolor and walnut, in addition, semen sojae atricolor albumen
It is made using extruding-puffing technique, effectively increases its protein digestibility, be easy to be absorbed by the body；
(3) preparation provided by the present invention for adjusting immune, antifatigue and relax bowel and defecation composition mainly uses wet process
Atomizing granulating technology combines dry mixing process when necessary, its nutrition mixing is more balanced for pure dry mixing, and can be preferably
The nutritive value of raw material is kept, mouthfeel is excellent, in addition, being used cooperatively fluidized bed prilling, substantially increases the solubility of product；
(4) it is proved by mouse experiment, after taking the composition, is remarkably improved the swimming time of mouse, reduces urea
With the content of blood lactase acid, the content of glycogen is improved, meanwhile, delayed anaphylaxis reaction (DTH), the peritoneal macrophage of mouse are swallowed
The generation of chicken red blood cell function (phagocytic rate), serum hemolysin significantly increases effect, and shows apparent dose-dependant
Relationship and organ index is all had no significant effect, in addition, the Intestinal propulsive rate of mice with constipation can be improved, shortens defecation time for the first time
With first grain melena efflux time, it is immune to illustrate that composition provided by the present invention can be adjusted effectively, it is antifatigue, and have both ease constipation
The function of defaecation；
(5) raw material provided by the present invention for adjusting immune, antifatigue and relax bowel and defecation composition is easy to get, needed for preparation
Condition and equipment are simple, and simple process is controllable, have highly important actual promotional value.
Specific embodiment
With reference to embodiment, the embodiment of the present invention is furthur described in detail.Following embodiment is used for
Illustrate the present invention, but be not limited to protection scope of the present invention, protection scope of the present invention is subject to claims.
Unless otherwise specified, experiment reagent used in the embodiment of the present invention and material etc. are commercially available, if not having
Body indicates, the conventional means that technological means used in the embodiment of the present invention is well known to the skilled person.
Raw materials used source in the embodiment of the present invention:
Semen sojae atricolor albumen is that northeast black soybean through physical squeezing oil removing, high temperature extrusion extruding and is ground, wherein oil
The content of rouge is 6.4wt%, and the content of protein is 42wt%, and the content of dietary fiber is 17.2wt%.
Soybean protein is commercial product, wherein the content of protein is 55wt%.
Pea protein is commercial product, wherein the content of protein is 84wt%.
Walnut protein is to cross 40-60 mesh after crushed by the walnut cakes after physical squeezing oil removing to be made, wherein albumen
The content of matter is 48wt%.
Oligofructose is commercial product, wherein the content of oligofructose is 72wt%.
Ginseng extract is the powdered extract of the dry root of Changbai Mountain road ground ginseng, withdrawal ratio 3.6:1, wherein
The content of ginsenoside is 12.4wt%.
Inulin is the natural inulin that the fructose degree of polymerization is 10-35.
Sweetener is one of antierythrite, xylitol, crystal diabetin, steviol glycoside and Fructus Momordicae fructoside or a variety of,
Preferably, sweetener includes: 0-22 parts of antierythrite, 0-15 parts of xylitol, 0-12 parts of crystal diabetin, 0-0.5 parts of steviol glycoside
With one of 0-0.5 parts of Fructus Momordicae fructoside or any several combination.
Nut fruit vegetable powder is commercial product, including bar denier wood powder, black sesame powder, pumpkin seed powder, blueberry powder, cherry powder, apple
One of fruit powder, broccoli powder and spinach powder are a variety of.
In preparation process of the present invention, unless otherwise specified, used means are this field conventional technology.
Embodiment 1
The present embodiment 1 provide it is a kind of with immunological regulation, antifatigue and relax bowel and defecation effect composition, by following weight
Part at being grouped as:
400 parts of semen sojae atricolor albumen, 200 parts of soybean protein, 180 parts of pea protein, 50 parts of walnut protein, 140 parts of oligofructose,
30 parts of ginseng extract.
The preparation method of above-mentioned composition, comprising the following steps:
S1, oligofructose and ginseng extract are mixed with sterile water according to the ratio, it is mixed obtains the base-material that concentration is 45wt%
Close liquid；
S2, base-material mixed liquor is sterilized into 12min at 115 DEG C；
S3, homogeneous 1 time at 45 DEG C, 32Mpa by the base-material mixed liquor after sterilization；
S4, then by the base-material mixed liquor after homogeneous in the condition that main air blower temperature is 175 DEG C, exhaust outlet temperature is 75 DEG C
Lower spray drying is granulated, and crosses 30 mesh vibrating screens to get base-material；
S5, finally that semen sojae atricolor albumen, soybean protein, pea protein, walnut protein and base-material is dry-mixed uniform according to the ratio, packaging
After detection to obtain the final product.
Embodiment 2
The present embodiment 2 provide it is a kind of with immunological regulation, antifatigue and relax bowel and defecation effect composition, by following weight
Part at being grouped as:
0 part of semen sojae atricolor protein 32,180 parts of soybean protein, 80 parts of pea protein, 50 parts of walnut protein, 170 parts of oligofructose.
The preparation method of above-mentioned composition, comprising the following steps:
S1, oligofructose is mixed with sterile water according to the ratio, obtains the base-material mixed liquor that concentration is 40wt%；
S2, base-material mixed liquor is sterilized into 10min at 115 DEG C；
S3, homogeneous 1 time at 45 DEG C, 40Mpa by the base-material mixed liquor after sterilization；
S4, then by the base-material mixed liquor after homogeneous main air blower temperature be 175 DEG C, exhaust outlet condition at a temperature of 90 °C
Lower spray drying is granulated, and crosses 30 mesh vibrating screens to get base-material；
S5, finally that semen sojae atricolor albumen, soybean protein, pea protein, walnut protein and base-material is dry-mixed uniform according to the ratio, packaging
After detection to obtain the final product.
Embodiment 3
The present embodiment 3 provide it is a kind of with immunological regulation, antifatigue and relax bowel and defecation effect composition, by following weight
Part at being grouped as:
0 part of semen sojae atricolor protein 42,120 parts of soybean protein, 135 parts of pea protein, 65 parts of walnut protein, 160 parts of oligofructose,
It is 48 parts of ginseng extract, 180 parts of inulin, 15 parts of black sesame powder, 20 parts of pumpkin seed powder, 18 parts of blueberry powder, 22 parts of broccoli powder, red
18 parts of moss sugar alcohol, 15 parts of xylitol, 0.3 part of Fructus Momordicae fructoside.
The preparation method of above-mentioned composition, comprising the following steps:
S1, above-mentioned each ingredient is mixed with sterile water according to the ratio, obtains the mixed liquor that concentration is 40wt%；
S2, mixed liquor is sterilized into 8min at 120 DEG C；
S3, homogeneous 2 times at 45 DEG C, 35Mpa by the mixed liquor after sterilization；
S4, finally by the mixed liquor after homogeneous under conditions of main air blower temperature is 180 DEG C, exhaust outlet temperature is 80 DEG C
Spray drying is granulated, excessively 30 mesh vibrating screens, after packaging detection to obtain the final product.
Embodiment 4
The present embodiment 4 provide it is a kind of with immunological regulation, antifatigue and relax bowel and defecation effect composition, by following weight
The component and step of part are made:
0 part of semen sojae atricolor protein 31,50 parts of soybean protein, 50 parts of pea protein, 15 parts of walnut protein, 60 parts of oligofructose, people
30 parts of conopsea extraction, 10 parts of black sesame powder, 130 parts of antierythrite.
The preparation method of above-mentioned composition, comprising the following steps:
S1, above-mentioned each ingredient is mixed with sterile water according to the ratio, obtains the mixed liquor that concentration is 40wt%；
S2, mixed liquor is sterilized into 8min at 120 DEG C；
S3, homogeneous 2 times at 45 DEG C, 35Mpa by the mixed liquor after sterilization；
S4, finally by the mixed liquor after homogeneous under conditions of main air blower temperature is 180 DEG C, exhaust outlet temperature is 80 DEG C
Spray drying is granulated, excessively 30 mesh vibrating screens, after packaging detection to obtain the final product.
Embodiment 5
The present embodiment 5 provide it is a kind of with immunological regulation, antifatigue and relax bowel and defecation effect composition, by following weight
Part at being grouped as:
0 part of semen sojae atricolor protein 43,100 parts of soybean protein, 200 parts of pea protein, 100 parts of walnut protein, 80 parts of oligofructose,
50 parts of inulin, 40 parts of pumpkin seed powder, 28 parts of blueberry powder, 18 parts of antierythrite.
The preparation method of above-mentioned composition, comprising the following steps:
S1, oligofructose, inulin, pumpkin seed powder, blueberry powder and antierythrite are mixed with sterile water according to the ratio, is obtained dense
Degree is the base-material mixed liquor of 45wt%；
S2, base-material mixed liquor is sterilized into 12min at 115 DEG C；
S3, homogeneous 1 time at 45 DEG C, 32Mpa by the base-material mixed liquor after sterilization；
S4, then by the base-material mixed liquor after homogeneous in the condition that main air blower temperature is 175 DEG C, exhaust outlet temperature is 75 DEG C
Lower spray drying is granulated, and crosses 30 mesh vibrating screens to get base-material；
S5, finally that semen sojae atricolor albumen, soybean protein, pea protein, walnut protein and base-material is dry-mixed uniform according to the ratio, packaging
After detection to obtain the final product.
Comparative example 1:
This comparative example provides a kind of composition, comprises the following components in parts by weight:
0 part of semen sojae atricolor protein 12,180 parts of soybean protein, 80 parts of pea protein, 450 parts of walnut protein, 170 parts of oligofructose.
The preparation method of above-mentioned composition, comprising the following steps:
S1, oligofructose is mixed with sterile water according to the ratio, obtains the base-material mixed liquor that concentration is 40wt%；
S2, base-material mixed liquor is sterilized into 10min at 115 DEG C；
S3, homogeneous 1 time at 45 DEG C, 40Mpa by the base-material mixed liquor after sterilization；
S4, then by the base-material mixed liquor after homogeneous main air blower temperature be 175 DEG C, exhaust outlet condition at a temperature of 90 °C
Lower spray drying is granulated, and crosses 30 mesh vibrating screens to get base-material；
S5, finally that semen sojae atricolor albumen, soybean protein, pea protein, walnut protein and base-material is dry-mixed uniform according to the ratio, packaging
After detection to obtain the final product.
Comparative example 2:
This comparative example provides a kind of composition, comprises the following components in parts by weight:
0 part of semen sojae atricolor protein 42,25 parts of soybean protein, 135 parts of pea protein, 65 parts of walnut protein, 160 parts of oligofructose,
It is 55 parts of ginseng extract, 160 parts of inulin, 15 parts of black sesame powder, 60 parts of pumpkin seed powder, 18 parts of blueberry powder, 82 parts of broccoli powder, red
18 parts of moss sugar alcohol, 45 parts of xylitol, 0.3 part of Fructus Momordicae fructoside.
The preparation method of above-mentioned composition, comprising the following steps:
S1, above-mentioned each ingredient is mixed with sterile water according to the ratio, obtains the mixed liquor that concentration is 40wt%；
S2, mixed liquor is sterilized into 8min at 120 DEG C；
S3, homogeneous 2 times at 45 DEG C, 35Mpa by the mixed liquor after sterilization；
S4, finally by the mixed liquor after homogeneous under conditions of main air blower temperature is 180 DEG C, exhaust outlet temperature is 80 DEG C
Spray drying is granulated, excessively 30 mesh vibrating screens, after packaging detection to obtain the final product.
Comparative example 3:
This comparative example provides a kind of composition, comprises the following components in parts by weight:
0 part of semen sojae atricolor protein 42,120 parts of soybean protein, 135 parts of pea protein, 65 parts of walnut protein, 160 parts of oligofructose,
It is 48 parts of ginseng extract, 180 parts of inulin, 15 parts of black sesame powder, 20 parts of pumpkin seed powder, 18 parts of blueberry powder, 22 parts of broccoli powder, red
18 parts of moss sugar alcohol, 15 parts of xylitol, 0.3 part of Fructus Momordicae fructoside.
In this comparative example, raw materials used source with it is essentially identical in embodiment, difference is, grease contains in semen sojae atricolor albumen
Amount is 15.4wt%, and the content of protein is 8wt%, and the content of dietary fiber is 4.2wt%, in addition, egg in walnut protein
The content of white matter is 17.5wt%.
The preparation method of above-mentioned composition, comprising the following steps:
S1, above-mentioned each ingredient is mixed with sterile water according to the ratio, obtains the mixed liquor that concentration is 40wt%；
S2, mixed liquor is sterilized into 8min at 120 DEG C；
S3, homogeneous 2 times at 45 DEG C, 35Mpa by the mixed liquor after sterilization；
S4, finally by the mixed liquor after homogeneous under conditions of main air blower temperature is 180 DEG C, exhaust outlet temperature is 80 DEG C
Spray drying is granulated, excessively 30 mesh vibrating screens, after packaging detection to obtain the final product.
Experimental example
Functional experiment test: there is apparent treatment to prove the present invention to immune, antifatigue and relax bowel and defecation is adjusted
Effect, carries out test proof using zoopery, experimentation is as follows.
Study subject: selecting Kunming mouse, and weight 18-22g, ties up tonneau China experimental animal technology by Beijing by totally 120
Co., Ltd provides.
Experimental method:
Mouse is raised one week in the environment of room temperature (18-25 DEG C), relative humidity 50-80%, allows it to be freely eaten, drink
Water.
Mouse is randomly divided into 10 groups, every group 12:
Isometric normal saline solution is given in blank control group, stomach-filling；
2 product low, middle and high dose groups of embodiment, dosage are respectively as follows: 200mg/kg, 400mg/kg, 800mg/kg；
3 product low, middle and high dose groups of embodiment, dosage are respectively as follows: 200mg/kg, 400mg/kg, 800mg/kg；
Reference examples 1,1 product of comparative example, dosage 400mg/kg；
Reference examples 2,2 product of comparative example, dosage 400mg/kg；
Reference examples 3,3 product of comparative example, dosage 400mg/kg.
Successive administration starts to test after 15 days.
1, antifatigue test
After last is to sample 30min, by the weight bearing iron wire of mouse weight 5%, putting it into 25 ± 1 DEG C of water temperature of sink makes it
Swimming, the depth of water are no less than 30cm, start timing, until mouse sinks under water, 8s does not refloat, and exhausting swimming for power terminates, record trip
It swims the time.
After last is to sample 30min, takes a blood sample, adopt after the not swimming with a load attached to the body 90min in the water that temperature is 30 DEG C, rest 60min
Blood about 0.5mL sets 4 DEG C of refrigerator about 3h, and 2000 turns/min is centrifuged 15min after blood clotting, takes serum spare.Urea in serum is in room
It can stablize for 24 hours under temperature, can stablize at 4-6 DEG C 7 days or more, build up the detection of Bioengineering Research Institute's urea detection kit with Nanjing
Urea content.
Take a blood sample 20 μ L after last dose 30min, does not then bear a heavy burden after 30 DEG C of water went swimming 10min and rest 20min
Respectively take a blood sample 20 μ L again afterwards, is taken a blood sample with capillary from eye socket endocanthion；Take a blood sample 20 μ L, is added in 40 μ L rupture of membranes liquid, fullys shake immediately
Smudge cells build up biotech firm's lactate acid detection kit detection lactic acid content with Nanjing.
After last is to sample 30min, mouse is put to death, liver is taken, is blotted after physiological saline rinses with filter paper, accurately weigh liver
8mL TCA is added in dirty 100mg, and every pipe is homogenized 1min, homogenate is poured into centrifuge tube, is centrifuged 15min with 3000 turns/min, will
Supernatant is transferred in another test tube, detects hepatic glycogen content with anthrone method.
As a result as shown in table 1 below.
The antifatigue experimental result table of comparisons of 1 each experimental example of the present invention of table
* P < 0.05 compared with blank control group；P < 0.01 compared with blank control group *.
As can be seen from Table 1, embodiment 2 and each dosage group of 3 sample of embodiment be remarkably improved mouse swimming time,
Urea content is reduced, Serum lactic acid content is reduced, improves glycogen content, and embodiment 3 is better than embodiment 2 on the whole；Reference examples are then
In swimming time, urea, Serum lactic acid content, hepatic glycogen content without remarkable effect compared with control group, in terms of anti-physical fatigue
Effect does not protrude.Generally speaking, antifatigue effect example is better than comparative example.
2, immunity is tested
Nonspecific immunity function-Turnover of Mouse Peritoneal Macrophages phagocytosis chicken red blood cell experiment: after animal dislocation is put to death, every
Mouse peritoneal injection contains the Hank's liquid 2ml of 5% fetal calf serum, is drawn in abdominal cavity washing lotion to test tube with suction pipe；By the abdominal cavity 0.3ml
Washing lotion is added in the chicken erythrocyte suspension for filling 0.3ml 1%；Drop is on slide and push jack after mixing, 37 DEG C of incubation 30min；
Physiology salt is washed 3 times after incubation, fixes 1min with methanol solution, Giemsa liquid dyes 15min；With distilled water flushing, dry；
The phagocytosis situation of oily microscopic observation Turnover of Mouse Peritoneal Macrophages counts the number that chicken red blood cell is swallowed in 100 macrophages, meter
Calculate phagocytic percentage.
Cellular immune function-delayed allergy (DTH): it is left with vernier caliper measurement that experimental animal puts to death the previous day
Metapedes toe thickness, the 20 μ l of SRBC every of subcutaneous injection 20% in measuring point, for 24 hours after to measure left back toes portion again thick
Degree, same position repeatedly measure and are averaged, and indicate the thickness of DTH to attack the toes thickness difference of front and back.
Humoral immune function-serum hemolysin measurement: experiment beginning plucks eyeball first and takes blood, places about 1h, fills serum
It analyzes, 2000r/min is centrifuged 10min and separates serum, with 200 times of normal saline dilution；100 μ l of serum after dilution is set into Ep
Guan Zhong, sequentially adds 10% (v/v) SRBC, 50 μ l, and 100 μ l of complement (uses normal saline dilution 1:8)；It sets in 37 DEG C of waters bath with thermostatic control
After keeping the temperature 30min, ice bath terminates reaction, and 2000r/min is centrifuged 10min；50 μ l of supernatant is taken to be added to flat 96 well culture plate
In, add 150 μ l of Dou Shi reagent；SRBC half hemolytic value adds 10% (v/v) SRBC, 12.5 μ l, adds 187.5 μ l of Dou Shi reagent；On
It states items and is all provided with three parallel holes, oscillation mixes 10min, and 540nm measures absorbance value, and calculates half hemolytic value.
The measurement of immune organ organ index: experiment terminates, and puts to death mouse, dissection mouse thymus, spleen weighing, by following
Formula calculates organ index: organ index=immune organ quality (mg)/weight (g).
The immunity test experiments comparison table of 2 each experimental example of the present invention of table
* P < 0.05 compared with blank control group；P < 0.01 compared with blank control group *.
As can be seen from Table 2, compared with blank control group, embodiment 2 and 3 to mouse delayed anaphylaxis reaction (DTH),
The generation of peritoneal macrophage phagocytosis chicken red blood cell function (phagocytic rate), serum hemolysin significantly increases effect (P <
0.05, P < 0.01), and show apparent dose-dependence；The two all has no significant effect organ index；Low dose of control group
Amount has centainly without effect, middle dose group delayed anaphylaxis reaction (DTH), peritoneal macrophage phagocytosis chicken red blood cell function (phagocytic rate)
It acts on (P < 0.05), high dose group then has remarkable effect in DTH and phagocytic rate, and display control group has in terms of improving immunity
Certain effect, but embodiment 2 and 3 is still below in terms of the overall evaluation improves immunity effect.
3, relax bowel and defecation is tested
2 groups of embodiment groups and 3 groups of reference examples groups are arranged in tested material, and blank control and model control group is arranged, setting sun
Property control, blank control group approach same as model control group gives distilled water, and given the test agent is given 7 days, can be extended down to when necessary
15 days.
Give after drug 0.5 hour, dosage group give respectively containing corresponding given the test agent prepared Chinese ink (containing 5% active carbon, 10%
Gum arabic), negative and model control group gives prepared Chinese ink stomach-filling.Neck is taken off after 25 minutes immediately and puts to death animal, opens abdominal cavity separation
Mesenterium, clip upper end are placed on pallet from pylorus, the intestinal tube of lower end to ileocecus, and small intestine is gently pulled into straight line, measure intestines
Length of tube is " total small intestinal length ", is from pylorus to prepared Chinese ink forward position " prepared Chinese ink propulsion length ".Ink progradation is calculated as follows: ink
Juice propulsion rate (%)=(prepared Chinese ink promotes length (cm))/(total small intestinal length (cm)) × 100%.
After giving drug 0.5 hour, negative control group and the prepared Chinese ink stomach-filling of model control group mouse, dosage group give containing by
Try the prepared Chinese ink of object sample, the raising of animal single cage, normal water feed.Since filling prepared Chinese ink, record every animal for the first time defecation when
Between and row's row's melena time for the first time, melena grain number and weight are arranged in 12 hours.
The relax bowel and defecation test experiments comparison table of 3 each experimental example of the present invention of table
* P < 0.05 compared with blank control group；P < 0.01 compared with blank control group *.
As can be seen from Table 3, in Constipation Model mouse, embodiment 2 and embodiment 3 can improve the small of mice with constipation
Alvine pushing rate shortens defecation time and first grain melena efflux time for the first time, and increases 12h stool quality, two high agent of embodiment
Amount group defecation effect can match in excellence or beauty normal mouse enteron aisle situation.It should be the result shows that embodiment 2 and embodiment 3 all have relax bowel and defecation
Effect, and 3 relax bowel and defecation effect of embodiment is better than embodiment 2；Control group is imitated without relax bowel and defecation in low dosage and middle dosage
Fruit has effect under the level of high dose group α=0.05, but whole is still worse than embodiment group.
By above-mentioned 3 mouse experiments it can be found that the present invention is with semen sojae atricolor albumen, soybean protein, pea protein, walnut egg
White, oligofructose composition as main component, it turned out that play the role of adjusting immune, antifatigue and relax bowel and defecation really, and
And each component compatibility is reasonable in present invention combination five, acts synergistically, effect is apparently higher than using one-component.
Finally, above the present invention is described in detail with a general description of the specific embodiments, but
On the basis of the present invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Cause
This, these modifications or improvements, fall within the scope of the claimed invention without departing from theon the basis of the spirit of the present invention.
Claims (10)
1. a kind of adjust immune, antifatigue and relax bowel and defecation composition, which is characterized in that the ingredient comprising following parts by weight:
300-800 parts of semen sojae atricolor albumen, 50-250 parts of soybean protein, 50-250 parts of pea protein, 10-200 parts of walnut protein, oligofructose
50-250 parts.
2. composition according to claim 1, which is characterized in that further include: 0.1-60 parts of ginseng extract, inulin 1.5-
250, one of nut fruit vegetable powder 0.2-120 parts and 0.5-200 parts of sweetener or a variety of.
3. composition according to claim 1 or 2, which is characterized in that the ingredient comprising following parts by weight: semen sojae atricolor albumen
350-500 parts, 100-200 parts of soybean protein, 100-200 parts of pea protein, 50-100 parts of walnut protein, oligofructose 80-180
Part, 10-60 parts of ginseng extract, 100-200 parts of inulin, 50-100 parts of nut fruit vegetable powder, 10-50 parts of sweetener.
4. composition according to claim 1-3, which is characterized in that in the semen sojae atricolor albumen, protein contains
Amount is no less than 12wt%, and the content of dietary fiber is no less than 6wt%；
Preferably, the semen sojae atricolor albumen is that semen sojae atricolor through physical squeezing oil removing, high temperature extrusion extruding and is ground, wherein
The content of grease is 4.5-10wt%, and the content of protein is 35-50wt%, and the content of dietary fiber is 15-18.5wt%.
5. composition according to claim 1-3, which is characterized in that
In the soybean protein, the content of protein is no less than 40wt%, preferably not less than 80wt%；
And/or in the pea protein, the content of protein is no less than 70wt%.
6. composition according to claim 1-3, which is characterized in that
The walnut protein is made of the walnut cakes after physical squeezing oil removing, wherein and the content of protein is 25-60wt%,
Preferably smash it through the particle of 40-60 mesh；
And/or in the oligofructose, oligofructose content is no less than 55wt%, preferably not less than 90wt%.
7. composition according to claim 2 or 3, which is characterized in that
The ginseng extract is the powdery or paste extract of the dry root of plant ginseng, wherein the content of ginsenoside is
1-20wt%；
And/or the inulin is the natural inulin that the fructose degree of polymerization is 10-35；
And/or the sweetener includes: 0-22 parts of antierythrite, 0-15 parts of xylitol, 0-12 parts of crystal diabetin, steviol glycoside
0-0.5 parts and one of Fructus Momordicae fructoside 0-0.5 parts or a variety of.
8. composition according to claim 2 or 3, which is characterized in that the nut fruit vegetable powder includes bar denier wood powder, black sesame
One of numb powder, pumpkin seed powder, blueberry powder, cherry powder, apple powder, broccoli powder and spinach powder are a variety of.
9. the preparation method of the described in any item compositions of claim 1-8, which is characterized in that
As protein content≤50wt% of the composition, comprising the following steps:
S1, each ingredient is mixed with sterile water according to the ratio, obtains the mixed liquor that concentration is 20-60wt%；
S2, mixed liquor is sterilized into 1-15min at 80-120 DEG C；
S3, by the mixed liquor after sterilization homogeneous 1-2 times at 40-50 DEG C, 20-45Mpa；
S4, finally by the mixed liquor after homogeneous in the item that main air blower temperature is 160-190 DEG C, exhaust outlet temperature is 65-90 DEG C
Be spray-dried under part, be granulated, cross 30 mesh vibrating screens to get；
When the protein content of the composition is greater than 50wt%, comprising the following steps:
S1, it will be mixed according to the ratio with sterile water except each ingredient of soybean protein and pea protein, obtaining concentration is 20-60wt%'s
Base-material mixed liquor；
S2, base-material mixed liquor is sterilized into 1-15min at 80-120 DEG C；
S3, by the base-material mixed liquor after sterilization homogeneous 1-2 times at 40-50 DEG C, 20-45Mpa；
S4, then by the base-material mixed liquor after homogeneous main air blower temperature is 160-190 DEG C, exhaust outlet temperature is 65-90 DEG C
Under the conditions of be spray-dried, be granulated, cross 30 mesh vibrating screens to get base-material；
S5, finally by soybean protein, pea protein and base-material according to the ratio it is dry-mixed uniformly to get.
10. the described in any item compositions of claim 1-8 or preparation method as claimed in claim 9 preparation adjust it is immune,
Application in antifatigue and relax bowel and defecation food, drug or health care product.
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