CN109355269B - 鞘氨醇激酶1及其融合蛋白及其用途 - Google Patents
鞘氨醇激酶1及其融合蛋白及其用途 Download PDFInfo
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- CN109355269B CN109355269B CN201811225720.2A CN201811225720A CN109355269B CN 109355269 B CN109355269 B CN 109355269B CN 201811225720 A CN201811225720 A CN 201811225720A CN 109355269 B CN109355269 B CN 109355269B
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Priority Applications (4)
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| CN201811225720.2A CN109355269B (zh) | 2018-10-21 | 2018-10-21 | 鞘氨醇激酶1及其融合蛋白及其用途 |
| PCT/CN2019/107091 WO2020082950A1 (zh) | 2018-10-21 | 2019-09-20 | 鞘氨醇激酶1及其融合蛋白及其用途 |
| JP2021523243A JP2022512843A (ja) | 2018-10-21 | 2019-09-20 | スフィンゴシンキナーゼ1とその融合タンパク質およびその使用 |
| US17/286,445 US20210388326A1 (en) | 2018-10-21 | 2019-09-20 | Sphingosine kinase 1 and fusion protein comprising the same and use thereof |
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| CN201811225720.2A CN109355269B (zh) | 2018-10-21 | 2018-10-21 | 鞘氨醇激酶1及其融合蛋白及其用途 |
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| CN109355269B true CN109355269B (zh) | 2020-03-24 |
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| CN109355269B (zh) * | 2018-10-21 | 2020-03-24 | 北京双因生物科技有限公司 | 鞘氨醇激酶1及其融合蛋白及其用途 |
| CN111303298B (zh) * | 2020-02-19 | 2023-03-21 | 李瑛� | 含有磷酸酶的融合蛋白及其产品和应用 |
| CN112143705B (zh) * | 2020-09-23 | 2022-09-06 | 北京华奥玄德生物医药科技有限公司 | 一种双基因修饰的干细胞及其用途 |
| CN114762724A (zh) * | 2020-12-31 | 2022-07-19 | 吴伯骥 | HrpWEch蛋白在识别激活多类受体和/或膜蛋白及其信号通路的制药中的应用 |
| CN114762723A (zh) * | 2020-12-31 | 2022-07-19 | 吴伯骥 | HrpZpst蛋白在识别激活多类受体和/或膜蛋白及其信号通路的制药中的应用 |
| CN112675293A (zh) * | 2020-12-31 | 2021-04-20 | 吴伯骥 | HrpNEcb蛋白在识别激活多类受体和/或膜蛋白及其信号通路的制药中的应用 |
Citations (2)
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| EP1228221A2 (en) * | 1999-10-28 | 2002-08-07 | Warner-Lambert Company | Human sphingosine kinase gene |
| CN107875398A (zh) * | 2017-09-27 | 2018-04-06 | 浙江大学 | 一种抗体偶联药物的制备方法、抗体偶联药物及应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6610534B2 (en) * | 2000-10-05 | 2003-08-26 | Novartis Ag | Induction of blood vessel formation through administration of polynucleotides encoding sphingosine kinases |
| WO2004061107A1 (ja) * | 2002-12-27 | 2004-07-22 | The New Industry Research Organization | スフィンゴシンキナーゼ2を利用した細胞増殖抑制剤、その核移行シグナルを持つ融合タンパク質の作製方法、及び薬剤候補物質のスクリーニング方法、並びにスクリーニングキット |
| WO2014135984A2 (en) * | 2013-03-07 | 2014-09-12 | Recopharma Ab | Glycosylated mucin-immunoglobulin fusion protein coated device |
| JP6324137B2 (ja) * | 2014-03-24 | 2018-05-16 | ジヤトコ株式会社 | シール機構付き車両用無段変速機 |
| CN106279430B (zh) * | 2015-06-30 | 2017-11-28 | 安源医药科技(上海)有限公司 | Exendin‑4类似物融合蛋白及其制备方法和用途 |
| CN106432511A (zh) * | 2016-09-29 | 2017-02-22 | 上海凯茂生物医药有限公司 | GLP‑1类似物‑Fc融合蛋白及其制备方法和用途 |
| CN109355269B (zh) * | 2018-10-21 | 2020-03-24 | 北京双因生物科技有限公司 | 鞘氨醇激酶1及其融合蛋白及其用途 |
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- 2019-09-20 US US17/286,445 patent/US20210388326A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1228221A2 (en) * | 1999-10-28 | 2002-08-07 | Warner-Lambert Company | Human sphingosine kinase gene |
| CN107875398A (zh) * | 2017-09-27 | 2018-04-06 | 浙江大学 | 一种抗体偶联药物的制备方法、抗体偶联药物及应用 |
Non-Patent Citations (5)
| Title |
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| immunoglobulin heavy chain, constant region, partial [Homo sapiens];CAA04843.1;《GenBank》;20160724;全文 * |
| Loss of sphingosine kinase 1 predisposes to the onset of diabetes via promoting pancreatic β-cell death in diet-induced obese mice;Qi Y等;《The FASEB Journal·Research Communication》;20130719;第27卷(第10期);全文 * |
| sphingosine kinase 1 isoform 3[Homo sapiens];NP_001136073.1;《GenBank》;20180212;序列和相关信息 * |
| 鞘氨醇激酶-1的乙酰化修饰及在糖尿病防治中的作用研究;于红阳;《中国博士学位论文全文数据库》;20130515;全文 * |
| 鞘氨醇激酶在糖代谢调控中的作用研究;马萌萌;《中国博士学位论文全文数据库》;20090415;摘要、第19-87页 * |
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| US20210388326A1 (en) | 2021-12-16 |
| CN109355269A (zh) | 2019-02-19 |
| WO2020082950A1 (zh) | 2020-04-30 |
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