CN109298021A - 用于诊断结核的传感器技术 - Google Patents
用于诊断结核的传感器技术 Download PDFInfo
- Publication number
- CN109298021A CN109298021A CN201811247574.3A CN201811247574A CN109298021A CN 109298021 A CN109298021 A CN 109298021A CN 201811247574 A CN201811247574 A CN 201811247574A CN 109298021 A CN109298021 A CN 109298021A
- Authority
- CN
- China
- Prior art keywords
- sensor
- tuberculosis
- sample
- coating
- carbon nanotube
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 201000008827 tuberculosis Diseases 0.000 title claims abstract description 153
- 238000003745 diagnosis Methods 0.000 title abstract description 23
- 238000005516 engineering process Methods 0.000 title abstract description 17
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims abstract description 44
- 238000004422 calculation algorithm Methods 0.000 claims abstract description 28
- 230000004044 response Effects 0.000 claims description 72
- 239000011248 coating agent Substances 0.000 claims description 56
- 238000000576 coating method Methods 0.000 claims description 56
- BKOOMYPCSUNDGP-UHFFFAOYSA-N 2-methylbut-2-ene Chemical compound CC=C(C)C BKOOMYPCSUNDGP-UHFFFAOYSA-N 0.000 claims description 54
- 238000000034 method Methods 0.000 claims description 53
- 239000002109 single walled nanotube Substances 0.000 claims description 52
- 238000004458 analytical method Methods 0.000 claims description 46
- 239000012855 volatile organic compound Substances 0.000 claims description 41
- 230000029058 respiratory gaseous exchange Effects 0.000 claims description 39
- 239000000758 substrate Substances 0.000 claims description 30
- 238000001514 detection method Methods 0.000 claims description 27
- 238000000513 principal component analysis Methods 0.000 claims description 27
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 21
- 238000012706 support-vector machine Methods 0.000 claims description 16
- 239000003990 capacitor Substances 0.000 claims description 15
- 238000013528 artificial neural network Methods 0.000 claims description 13
- 239000000126 substance Substances 0.000 claims description 13
- 238000012545 processing Methods 0.000 claims description 12
- 230000003287 optical effect Effects 0.000 claims description 11
- 238000003860 storage Methods 0.000 claims description 11
- 238000010897 surface acoustic wave method Methods 0.000 claims description 11
- 210000004027 cell Anatomy 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 9
- 229940079593 drug Drugs 0.000 claims description 9
- 208000031886 HIV Infections Diseases 0.000 claims description 7
- 230000008859 change Effects 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 239000013078 crystal Substances 0.000 claims description 6
- 230000005611 electricity Effects 0.000 claims description 5
- 230000005669 field effect Effects 0.000 claims description 5
- 238000012628 principal component regression Methods 0.000 claims description 5
- 208000037357 HIV infectious disease Diseases 0.000 claims description 4
- 230000002068 genetic effect Effects 0.000 claims description 4
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims description 4
- 230000003044 adaptive effect Effects 0.000 claims description 3
- 238000012417 linear regression Methods 0.000 claims description 3
- 210000005036 nerve Anatomy 0.000 claims description 3
- 230000036961 partial effect Effects 0.000 claims description 3
- 239000010453 quartz Substances 0.000 claims description 3
- 230000001537 neural effect Effects 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 239000004575 stone Substances 0.000 claims 1
- 239000010931 gold Substances 0.000 abstract description 42
- 229910052737 gold Inorganic materials 0.000 abstract description 40
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 abstract description 39
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract description 35
- 239000002041 carbon nanotube Substances 0.000 abstract description 13
- 229910021393 carbon nanotube Inorganic materials 0.000 abstract description 13
- 239000002086 nanomaterial Substances 0.000 abstract description 9
- 238000012216 screening Methods 0.000 abstract description 7
- 239000000523 sample Substances 0.000 description 115
- 238000012360 testing method Methods 0.000 description 68
- 235000013339 cereals Nutrition 0.000 description 36
- WNAHIZMDSQCWRP-UHFFFAOYSA-N dodecane-1-thiol Chemical class CCCCCCCCCCCCS WNAHIZMDSQCWRP-UHFFFAOYSA-N 0.000 description 23
- 230000035945 sensitivity Effects 0.000 description 23
- 238000005259 measurement Methods 0.000 description 19
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 18
- 239000013068 control sample Substances 0.000 description 16
- 230000006870 function Effects 0.000 description 16
- 238000012549 training Methods 0.000 description 14
- 239000000203 mixture Substances 0.000 description 12
- 239000000243 solution Substances 0.000 description 12
- 238000010606 normalization Methods 0.000 description 11
- 239000002594 sorbent Substances 0.000 description 11
- 208000015181 infectious disease Diseases 0.000 description 10
- 230000000391 smoking effect Effects 0.000 description 10
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 9
- 239000010410 layer Substances 0.000 description 9
- 239000000463 material Substances 0.000 description 9
- 230000008569 process Effects 0.000 description 9
- 239000010703 silicon Substances 0.000 description 9
- 229910052710 silicon Inorganic materials 0.000 description 9
- 201000010099 disease Diseases 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 239000011159 matrix material Substances 0.000 description 8
- 238000011160 research Methods 0.000 description 8
- 210000001124 body fluid Anatomy 0.000 description 7
- 239000010839 body fluid Substances 0.000 description 7
- 229910052799 carbon Inorganic materials 0.000 description 7
- 230000036541 health Effects 0.000 description 7
- 230000028327 secretion Effects 0.000 description 7
- 239000000377 silicon dioxide Substances 0.000 description 7
- 241000894006 Bacteria Species 0.000 description 6
- 101100136092 Drosophila melanogaster peng gene Proteins 0.000 description 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
- 238000005229 chemical vapour deposition Methods 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 239000000284 extract Substances 0.000 description 6
- 239000007789 gas Substances 0.000 description 6
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 description 6
- 239000012071 phase Substances 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 5
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 description 5
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 5
- 206010036790 Productive cough Diseases 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 125000005575 polycyclic aromatic hydrocarbon group Chemical group 0.000 description 5
- 238000005070 sampling Methods 0.000 description 5
- 238000001179 sorption measurement Methods 0.000 description 5
- 210000003802 sputum Anatomy 0.000 description 5
- 208000024794 sputum Diseases 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 238000005266 casting Methods 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 238000009833 condensation Methods 0.000 description 4
- 230000005494 condensation Effects 0.000 description 4
- 238000000151 deposition Methods 0.000 description 4
- 230000008021 deposition Effects 0.000 description 4
- 238000009826 distribution Methods 0.000 description 4
- 238000004817 gas chromatography Methods 0.000 description 4
- 230000001965 increasing effect Effects 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 239000002105 nanoparticle Substances 0.000 description 4
- 230000008447 perception Effects 0.000 description 4
- -1 polyethylene Polymers 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 238000002470 solid-phase micro-extraction Methods 0.000 description 4
- 238000007619 statistical method Methods 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- UCJMHYXRQZYNNL-UHFFFAOYSA-N 2-Ethyl-1-hexanethiol Chemical compound CCCCC(CC)CS UCJMHYXRQZYNNL-UHFFFAOYSA-N 0.000 description 3
- 229920002799 BoPET Polymers 0.000 description 3
- 208000035473 Communicable disease Diseases 0.000 description 3
- 241001529297 Coregonus peled Species 0.000 description 3
- 239000005041 Mylar™ Substances 0.000 description 3
- 239000000090 biomarker Substances 0.000 description 3
- 210000000481 breast Anatomy 0.000 description 3
- 150000001721 carbon Chemical group 0.000 description 3
- 239000003054 catalyst Substances 0.000 description 3
- 238000012512 characterization method Methods 0.000 description 3
- 239000012141 concentrate Substances 0.000 description 3
- 238000002790 cross-validation Methods 0.000 description 3
- 238000003795 desorption Methods 0.000 description 3
- 238000002405 diagnostic procedure Methods 0.000 description 3
- 235000019441 ethanol Nutrition 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 238000004377 microelectronic Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 238000004094 preconcentration Methods 0.000 description 3
- 229910002027 silica gel Inorganic materials 0.000 description 3
- 239000000741 silica gel Substances 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- FYGHSUNMUKGBRK-UHFFFAOYSA-N 1,2,3-trimethylbenzene Chemical compound CC1=CC=CC(C)=C1C FYGHSUNMUKGBRK-UHFFFAOYSA-N 0.000 description 2
- 101100350750 Arabidopsis thaliana PAH2 gene Proteins 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241001037822 Bacillus bacterium Species 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 229910004042 HAuCl4 Inorganic materials 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- 101150082238 PAH1 gene Proteins 0.000 description 2
- 101100029356 Pichia angusta PEX5 gene Proteins 0.000 description 2
- 239000004642 Polyimide Substances 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000003321 amplification Effects 0.000 description 2
- 239000012491 analyte Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 244000309464 bull Species 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 239000003610 charcoal Substances 0.000 description 2
- 235000013365 dairy product Nutrition 0.000 description 2
- 238000007405 data analysis Methods 0.000 description 2
- 238000013480 data collection Methods 0.000 description 2
- 239000002274 desiccant Substances 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000011982 device technology Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000007717 exclusion Effects 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 229910002804 graphite Inorganic materials 0.000 description 2
- 239000010439 graphite Substances 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 238000004949 mass spectrometry Methods 0.000 description 2
- 238000000813 microcontact printing Methods 0.000 description 2
- 238000000845 micromoulding in capillary Methods 0.000 description 2
- 239000002808 molecular sieve Substances 0.000 description 2
- 239000002071 nanotube Substances 0.000 description 2
- 239000013642 negative control Substances 0.000 description 2
- 229960003512 nicotinic acid Drugs 0.000 description 2
- 235000001968 nicotinic acid Nutrition 0.000 description 2
- 239000011664 nicotinic acid Substances 0.000 description 2
- 238000003199 nucleic acid amplification method Methods 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 238000010422 painting Methods 0.000 description 2
- QMMOXUPEWRXHJS-UHFFFAOYSA-N pent-2-ene Chemical compound CCC=CC QMMOXUPEWRXHJS-UHFFFAOYSA-N 0.000 description 2
- 238000001259 photo etching Methods 0.000 description 2
- 238000000623 plasma-assisted chemical vapour deposition Methods 0.000 description 2
- 229920006267 polyester film Polymers 0.000 description 2
- 229920001721 polyimide Polymers 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 208000008128 pulmonary tuberculosis Diseases 0.000 description 2
- 238000005086 pumping Methods 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 238000001338 self-assembly Methods 0.000 description 2
- 239000004065 semiconductor Substances 0.000 description 2
- 235000012239 silicon dioxide Nutrition 0.000 description 2
- 238000011120 smear test Methods 0.000 description 2
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000003039 volatile agent Substances 0.000 description 2
- YIWUKEYIRIRTPP-UHFFFAOYSA-N 2-ethylhexan-1-ol Chemical compound CCCCC(CC)CO YIWUKEYIRIRTPP-UHFFFAOYSA-N 0.000 description 1
- 241000208340 Araliaceae Species 0.000 description 1
- 241000304886 Bacilli Species 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 206010006049 Bovine Tuberculosis Diseases 0.000 description 1
- BIMRNYDJQHZYKY-UHFFFAOYSA-N CCCCCCCCCCCC.[S] Chemical compound CCCCCCCCCCCC.[S] BIMRNYDJQHZYKY-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 201000003883 Cystic fibrosis Diseases 0.000 description 1
- 102100036702 Glucosamine-6-phosphate isomerase 2 Human genes 0.000 description 1
- 208000000616 Hemoptysis Diseases 0.000 description 1
- 101100283455 Homo sapiens GNPDA2 gene Proteins 0.000 description 1
- 101000685663 Homo sapiens Sodium/nucleoside cotransporter 1 Proteins 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 101100465000 Mus musculus Prag1 gene Proteins 0.000 description 1
- 241000186359 Mycobacterium Species 0.000 description 1
- 208000031998 Mycobacterium Infections Diseases 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 101100505264 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GNP1 gene Proteins 0.000 description 1
- 102100023116 Sodium/nucleoside cotransporter 1 Human genes 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 208000036981 active tuberculosis Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000003679 aging effect Effects 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 229910000323 aluminium silicate Inorganic materials 0.000 description 1
- 238000000540 analysis of variance Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 229920001429 chelating resin Polymers 0.000 description 1
- 238000007385 chemical modification Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- KYKAJFCTULSVSH-UHFFFAOYSA-N chloro(fluoro)methane Chemical compound F[C]Cl KYKAJFCTULSVSH-UHFFFAOYSA-N 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000012631 diagnostic technique Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 150000001993 dienes Chemical class 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000010891 electric arc Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000003344 environmental pollutant Substances 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 150000002168 ethanoic acid esters Chemical class 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- KTWOOEGAPBSYNW-UHFFFAOYSA-N ferrocene Chemical compound [Fe+2].C=1C=C[CH-]C=1.C=1C=C[CH-]C=1 KTWOOEGAPBSYNW-UHFFFAOYSA-N 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 229910052738 indium Inorganic materials 0.000 description 1
- MRNHPUHPBOKKQT-UHFFFAOYSA-N indium;tin;hydrate Chemical compound O.[In].[Sn] MRNHPUHPBOKKQT-UHFFFAOYSA-N 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000012212 insulator Substances 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 238000000608 laser ablation Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000001459 lithography Methods 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 210000004324 lymphatic system Anatomy 0.000 description 1
- 238000010801 machine learning Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000002082 metal nanoparticle Substances 0.000 description 1
- 239000003863 metallic catalyst Substances 0.000 description 1
- 230000001035 methylating effect Effects 0.000 description 1
- 230000011987 methylation Effects 0.000 description 1
- 238000007069 methylation reaction Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 208000027531 mycobacterial infectious disease Diseases 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 238000000879 optical micrograph Methods 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 238000003909 pattern recognition Methods 0.000 description 1
- 238000005502 peroxidation Methods 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 231100000719 pollutant Toxicity 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920005547 polycyclic aromatic hydrocarbon Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000013139 quantization Methods 0.000 description 1
- 238000003380 quartz crystal microbalance Methods 0.000 description 1
- 239000012857 radioactive material Substances 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 238000001878 scanning electron micrograph Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 238000011895 specific detection Methods 0.000 description 1
- 238000004528 spin coating Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000000528 statistical test Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
- QBVXKDJEZKEASM-UHFFFAOYSA-M tetraoctylammonium bromide Chemical compound [Br-].CCCCCCCC[N+](CCCCCCCC)(CCCCCCCC)CCCCCCCC QBVXKDJEZKEASM-UHFFFAOYSA-M 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 230000002463 transducing effect Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 150000003624 transition metals Chemical class 0.000 description 1
- 229960001005 tuberculin Drugs 0.000 description 1
- 210000002229 urogenital system Anatomy 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 229910009112 xH2O Inorganic materials 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Measuring devices for evaluating the respiratory organs
- A61B5/082—Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
- G01N27/04—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
- G01N27/04—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
- G01N27/12—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon absorption of a fluid; of a solid body in dependence upon reaction with a fluid, for detecting components in the fluid
- G01N27/125—Composition of the body, e.g. the composition of its sensitive layer
- G01N27/127—Composition of the body, e.g. the composition of its sensitive layer comprising nanoparticles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
- G01N27/22—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating capacitance
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
- G01N33/4975—Physical analysis of biological material of gaseous biological material, e.g. breath other than oxygen, carbon dioxide or alcohol, e.g. organic vapours
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
- G01N27/22—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating capacitance
- G01N27/221—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating capacitance by investigating the dielectric properties
- G01N2027/222—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating capacitance by investigating the dielectric properties for analysing gases
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/35—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Mycobacteriaceae (F)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/12—Pulmonary diseases
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/26—Infectious diseases, e.g. generalised sepsis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Electrochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Hematology (AREA)
- Nanotechnology (AREA)
- Surgery (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Physiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Investigating Or Analyzing Materials By The Use Of Fluid Adsorption Or Reactions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261719559P | 2012-10-29 | 2012-10-29 | |
| US61/719,559 | 2012-10-29 | ||
| CN201380056685.5A CN104781666B (zh) | 2012-10-29 | 2013-10-27 | 用于诊断结核的传感器技术 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380056685.5A Division CN104781666B (zh) | 2012-10-29 | 2013-10-27 | 用于诊断结核的传感器技术 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109298021A true CN109298021A (zh) | 2019-02-01 |
Family
ID=50626576
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811247574.3A Pending CN109298021A (zh) | 2012-10-29 | 2013-10-27 | 用于诊断结核的传感器技术 |
| CN201380056685.5A Expired - Fee Related CN104781666B (zh) | 2012-10-29 | 2013-10-27 | 用于诊断结核的传感器技术 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380056685.5A Expired - Fee Related CN104781666B (zh) | 2012-10-29 | 2013-10-27 | 用于诊断结核的传感器技术 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10168315B2 (https=) |
| CN (2) | CN109298021A (https=) |
| IL (1) | IL264823B (https=) |
| IN (1) | IN2015DN04092A (https=) |
| WO (1) | WO2014068554A1 (https=) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN2015DN04092A (https=) * | 2012-10-29 | 2015-10-09 | Technion Res & Dev Foundation | |
| CN106687811B (zh) * | 2014-07-15 | 2021-08-17 | C2感官有限公司 | 用于增强化学电阻感测的制剂 |
| EP2998737B1 (en) | 2014-09-18 | 2021-04-21 | Nokia Technologies Oy | An apparatus and method for controllably populating a channel with charge carriers using quantum dots attached to the channel and Resonance Energy Transfer. |
| US11262354B2 (en) | 2014-10-20 | 2022-03-01 | Boston Scientific Scimed, Inc. | Disposable sensor elements, systems, and related methods |
| EP3230706B1 (en) | 2014-12-09 | 2021-02-03 | Technion Research & Development Foundation Ltd. | High resolution pressure sensing |
| CN104970769A (zh) * | 2015-06-09 | 2015-10-14 | 黄义超 | 结核病种类诊断装置 |
| WO2017087749A1 (en) * | 2015-11-20 | 2017-05-26 | Drexel University | Rapid antimicrobial susceptibility testing using piezoelectric sensor |
| US10670566B2 (en) | 2015-11-20 | 2020-06-02 | Drexel University | Rapid antimicrobial susceptibility testing using piezoelectric sensor |
| ES2979317T3 (es) | 2016-06-15 | 2024-09-25 | Univ Minnesota | Catéteres de muestreo de gas |
| EP3472613A4 (en) * | 2016-06-16 | 2020-10-07 | Technion Research & Development Foundation Ltd. | DIFFERENTIAL DISEASE DIAGNOSIS SYSTEM AND METHOD |
| US11172846B2 (en) | 2016-10-21 | 2021-11-16 | Boston Scientific Scimed, Inc. | Gas sampling device |
| CN106770485B (zh) * | 2017-01-25 | 2019-06-21 | 吉林大学 | 一种导电内核敏感层及分子筛除湿层的传感器及制备方法 |
| WO2018173060A1 (en) * | 2017-03-23 | 2018-09-27 | Technion Research & Development Foundation Ltd. | Device and methods for detection and monitoring of tuberculosis |
| US10770182B2 (en) | 2017-05-19 | 2020-09-08 | Boston Scientific Scimed, Inc. | Systems and methods for assessing the health status of a patient |
| US10852264B2 (en) | 2017-07-18 | 2020-12-01 | Boston Scientific Scimed, Inc. | Systems and methods for analyte sensing in physiological gas samples |
| US11331019B2 (en) | 2017-08-07 | 2022-05-17 | The Research Foundation For The State University Of New York | Nanoparticle sensor having a nanofibrous membrane scaffold |
| CN119044254A (zh) * | 2018-01-04 | 2024-11-29 | 利腾股份有限公司 | 谐振气体传感器 |
| US11988628B2 (en) | 2018-01-04 | 2024-05-21 | Lyten, Inc. | Container including analyte sensing device |
| US11913901B2 (en) | 2018-01-04 | 2024-02-27 | Lyten, Inc. | Analyte sensing device |
| US12119462B2 (en) | 2018-01-04 | 2024-10-15 | Lyten, Inc. | Sensing device for detecting analytes in batteries |
| US11137368B2 (en) | 2018-01-04 | 2021-10-05 | Lyten, Inc. | Resonant gas sensor |
| FR3078880A1 (fr) * | 2018-03-14 | 2019-09-20 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Systeme de prelevement d'un echantillon d'air expire par un etre vivant |
| US10362769B1 (en) | 2018-03-23 | 2019-07-30 | International Business Machines Corporation | System and method for detection of disease breakouts |
| CN108742630B (zh) * | 2018-07-05 | 2023-07-25 | 河北工业大学 | 一种呼气纳米传感健康预警系统及实现方法 |
| WO2020072363A1 (en) | 2018-10-01 | 2020-04-09 | BoydSense, Inc. | Breath sensing system and methods of use |
| CN112930480A (zh) | 2018-10-19 | 2021-06-08 | 明尼苏达大学董事会 | 用于检测脑病症的系统和方法 |
| IL262771B (en) | 2018-11-04 | 2021-06-30 | Voclarity Health LLC | Methods and system for associating between discharge of chemicals, and corresponding genetic, medical and/or pathological conditions |
| CN113167758A (zh) | 2018-11-27 | 2021-07-23 | 波士顿科学国际有限公司 | 用于检测健康状况的系统和方法 |
| WO2020131567A1 (en) | 2018-12-18 | 2020-06-25 | Boston Scientific Scimed, Inc. | Systems and methods for measuring kinetic response of chemical sensor elements |
| US20220236242A1 (en) * | 2019-07-12 | 2022-07-28 | North Carolina State University | Methods and systems for assessing plant conditions by volatile detection |
| US20220412952A1 (en) * | 2019-12-01 | 2022-12-29 | Nanoscent Ltd. | Use of a chemiresistor sensor for improving health |
| US20230152319A1 (en) * | 2020-04-21 | 2023-05-18 | Technion Research And Development Foundation Ltd. | Device and method for rapid detection of viruses |
| US11988660B2 (en) * | 2020-08-04 | 2024-05-21 | Richard Postrel | Rapid screening for infectious diseases |
| US11760170B2 (en) | 2020-08-20 | 2023-09-19 | Denso International America, Inc. | Olfaction sensor preservation systems and methods |
| US11881093B2 (en) | 2020-08-20 | 2024-01-23 | Denso International America, Inc. | Systems and methods for identifying smoking in vehicles |
| US12251991B2 (en) | 2020-08-20 | 2025-03-18 | Denso International America, Inc. | Humidity control for olfaction sensors |
| US11813926B2 (en) | 2020-08-20 | 2023-11-14 | Denso International America, Inc. | Binding agent and olfaction sensor |
| US11760169B2 (en) | 2020-08-20 | 2023-09-19 | Denso International America, Inc. | Particulate control systems and methods for olfaction sensors |
| US12269315B2 (en) | 2020-08-20 | 2025-04-08 | Denso International America, Inc. | Systems and methods for measuring and managing odor brought into rental vehicles |
| US12017506B2 (en) | 2020-08-20 | 2024-06-25 | Denso International America, Inc. | Passenger cabin air control systems and methods |
| US11636870B2 (en) | 2020-08-20 | 2023-04-25 | Denso International America, Inc. | Smoking cessation systems and methods |
| US12377711B2 (en) | 2020-08-20 | 2025-08-05 | Denso International America, Inc. | Vehicle feature control systems and methods based on smoking |
| US11932080B2 (en) | 2020-08-20 | 2024-03-19 | Denso International America, Inc. | Diagnostic and recirculation control systems and methods |
| US11828210B2 (en) | 2020-08-20 | 2023-11-28 | Denso International America, Inc. | Diagnostic systems and methods of vehicles using olfaction |
| US20240044832A1 (en) * | 2020-12-21 | 2024-02-08 | Technion Research And Development Foundation Ltd. | Methods for diagnosing cancer based on volatile organic compounds in blood and urine samples |
| US20240315591A1 (en) * | 2021-01-07 | 2024-09-26 | Nanose Medical Ltd | Detection of respiratory tract infections (rtis) |
| US12480907B2 (en) | 2021-04-16 | 2025-11-25 | Regents Of The University Of Minnesota | Systems utilizing graphene varactor hysteresis effects for sample characterization |
| US12551142B2 (en) | 2021-05-22 | 2026-02-17 | Tao Treasures, Llc | Noninvasive device for monitor, detection, and diagnosis of diseases and human performance |
| WO2023078961A1 (en) * | 2021-11-02 | 2023-05-11 | Pexa Ab | A device and method for determining a respiratory system infection from exhaled breath |
| US20240260880A1 (en) * | 2022-06-08 | 2024-08-08 | Spotitearly Ltd. | Machine Learning (ML)-based Disease-Detection System Using Detection Animals |
| US20240264145A1 (en) * | 2023-02-07 | 2024-08-08 | Aleck Alexopoulos | Device, method, and system for the rapid detection of the tuberculosis mycobacterium dispersed in air |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102262122A (zh) * | 2011-06-21 | 2011-11-30 | 温州大学 | 一种基于单壁碳纳米管的超灵敏dna生物传感器及制备方法和应用 |
| CN102300502A (zh) * | 2008-12-01 | 2011-12-28 | 创控生技股份有限公司 | 用于哮喘、肺结核及肺癌诊断及疾病管控的呼吸分析系统及方法 |
| CN102326078A (zh) * | 2009-01-09 | 2012-01-18 | 技术研究及发展基金有限公司 | 包括含有涂覆的导电纳米颗粒的传感器阵列的通过呼气检测癌症 |
| GB2489504A (en) * | 2011-03-31 | 2012-10-03 | Sapient Sensors | A device for identifying the presence of a specific target molecule or biomarker by sensing an electrical property |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5571401A (en) * | 1995-03-27 | 1996-11-05 | California Institute Of Technology | Sensor arrays for detecting analytes in fluids |
| US6221673B1 (en) * | 1997-11-25 | 2001-04-24 | Microsensor Systems Inc. | Materials, method and apparatus for detection and monitoring of chemical species |
| US6773926B1 (en) * | 2000-09-25 | 2004-08-10 | California Institute Of Technology | Nanoparticle-based sensors for detecting analytes in fluids |
| AU2002309803A1 (en) | 2001-04-17 | 2002-10-28 | University Of Virginia Patent Foundation | Breath test for assessing diseases, particularly asthma |
| US7153272B2 (en) | 2002-01-29 | 2006-12-26 | Nanotherapeutics, Inc. | Methods of collecting and analyzing human breath |
| JP2005519291A (ja) * | 2002-03-04 | 2005-06-30 | シラノ サイエンシズ インコーポレイテッド | 人工的嗅覚検査による医学疾患または病気の検知、診断、およびモニタリング |
| WO2009054913A1 (en) | 2007-10-19 | 2009-04-30 | The Charles Stark Draper Laboratory, Inc. | Rapid detection of volatile organic compounds for identification of bacteria in a sample |
| EP2215464B1 (en) | 2007-11-20 | 2015-10-07 | Technion Research & Development Foundation Ltd. | Sensor system, use of sensor and method for sensing based on cubic nanoparticles capped with an organic coating |
| US8366630B2 (en) * | 2008-05-29 | 2013-02-05 | Technion Research And Development Foundation Ltd. | Carbon nanotube structures in sensor apparatuses for analyzing biomarkers in breath samples |
| WO2010064239A1 (en) | 2008-12-04 | 2010-06-10 | Technion Research And Development Foundation Ltd. | Apparatus and methods for diagnosing renal disorders |
| WO2010126856A1 (en) | 2009-04-27 | 2010-11-04 | The Charles Stark Draper Laboratory, Inc. | Rapid detection of volatile organic compounds for identification of mycobacterium tuberculosis in a sample |
| US9678059B2 (en) | 2010-05-23 | 2017-06-13 | Technion Research & Development Foundation Ltd. | Detection, staging and grading of benign and malignant tumors |
| WO2012023138A2 (en) | 2010-08-18 | 2012-02-23 | Technion Research And Development Foundation Ltd. | Volatile organic compounds for detecting cell dysplasia and genetic alterations associated with lung cancer |
| US9359197B2 (en) | 2011-03-24 | 2016-06-07 | Technion Research & Development Foundation Ltd. | Method of diagnosing, prognosing and monitoring parkinson's disease |
| US8945935B2 (en) | 2011-08-04 | 2015-02-03 | Technion Research & Development Foundation Ltd. | Diagnosing, prognosing and monitoring multiple sclerosis |
| US9528979B2 (en) | 2011-11-15 | 2016-12-27 | Technion Research And Development Foundation Ltd. | Breath analysis of pulmonary nodules |
| IN2015DN04092A (https=) * | 2012-10-29 | 2015-10-09 | Technion Res & Dev Foundation |
-
2013
- 2013-10-27 IN IN4092DEN2015 patent/IN2015DN04092A/en unknown
- 2013-10-27 CN CN201811247574.3A patent/CN109298021A/zh active Pending
- 2013-10-27 CN CN201380056685.5A patent/CN104781666B/zh not_active Expired - Fee Related
- 2013-10-27 WO PCT/IL2013/050874 patent/WO2014068554A1/en not_active Ceased
- 2013-10-27 US US14/438,807 patent/US10168315B2/en active Active
-
2018
- 2018-10-26 US US16/172,118 patent/US10837956B2/en active Active
-
2019
- 2019-02-13 IL IL264823A patent/IL264823B/en active IP Right Grant
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102300502A (zh) * | 2008-12-01 | 2011-12-28 | 创控生技股份有限公司 | 用于哮喘、肺结核及肺癌诊断及疾病管控的呼吸分析系统及方法 |
| CN102326078A (zh) * | 2009-01-09 | 2012-01-18 | 技术研究及发展基金有限公司 | 包括含有涂覆的导电纳米颗粒的传感器阵列的通过呼气检测癌症 |
| GB2489504A (en) * | 2011-03-31 | 2012-10-03 | Sapient Sensors | A device for identifying the presence of a specific target molecule or biomarker by sensing an electrical property |
| CN102262122A (zh) * | 2011-06-21 | 2011-11-30 | 温州大学 | 一种基于单壁碳纳米管的超灵敏dna生物传感器及制备方法和应用 |
Non-Patent Citations (2)
| Title |
|---|
| GANG PENG 等: "Diagnosing lung cancer in exhaled breath using gold nanoparticles", 《NATURE NANOTECHNOLOGY》 * |
| KHALID MUZAFFAR BANDAY 等: "Use of Urine Volatile Organic Compounds To Discriminate Tuberculosis Patients from Healthy Subjects", 《ANALYTICAL CHEMISTRY》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104781666A (zh) | 2015-07-15 |
| IN2015DN04092A (https=) | 2015-10-09 |
| WO2014068554A1 (en) | 2014-05-08 |
| US20190064143A1 (en) | 2019-02-28 |
| US20150301021A1 (en) | 2015-10-22 |
| IL264823B (en) | 2020-09-30 |
| US10837956B2 (en) | 2020-11-17 |
| CN104781666B (zh) | 2018-11-13 |
| US10168315B2 (en) | 2019-01-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10837956B2 (en) | Sensor technology for diagnosing tuberculosis | |
| Nurputra et al. | Fast and noninvasive electronic nose for sniffing out COVID-19 based on exhaled breath-print recognition | |
| US12064239B2 (en) | Device and methods for detection and monitoring of tuberculosis | |
| Xue et al. | An intelligent face mask integrated with high density conductive nanowire array for directly exhaled coronavirus aerosols screening | |
| Alizadeh et al. | Breath acetone sensors as non-invasive health monitoring systems: A review | |
| Chen et al. | Smart gas sensor arrays powered by artificial intelligence | |
| US8481324B2 (en) | Apparatus and methods for diagnosing renal disorders | |
| US8945935B2 (en) | Diagnosing, prognosing and monitoring multiple sclerosis | |
| Konvalina et al. | Effect of humidity on nanoparticle-based chemiresistors: a comparison between synthetic and real-world samples | |
| Broza et al. | Synergy between nanomaterials and volatile organic compounds for non-invasive medical evaluation | |
| US9365419B2 (en) | Method of diagnosing, prognosing and monitoring alzheimer's disease | |
| Shehada et al. | Silicon nanowire sensors enable diagnosis of patients via exhaled breath | |
| US9678059B2 (en) | Detection, staging and grading of benign and malignant tumors | |
| US11181519B2 (en) | System and method for differential diagnosis of diseases | |
| Vishinkin et al. | Nanoscale sensor technologies for disease detection via volatolomics | |
| US9689826B2 (en) | Detection of chronic kidney disease and disease progression | |
| Broza et al. | Nanomaterial-based sensors for detection of disease by volatile organic compounds | |
| US8366630B2 (en) | Carbon nanotube structures in sensor apparatuses for analyzing biomarkers in breath samples | |
| CN103018282B (zh) | 用于肺癌早期检测的电子鼻系统 | |
| Harun-Or-Rashid et al. | Nanomaterial innovations and machine learning in gas sensing technologies for real-time health diagnostics | |
| Kim et al. | Exhaled breath sensors | |
| CN102326078A (zh) | 包括含有涂覆的导电纳米颗粒的传感器阵列的通过呼气检测癌症 | |
| Hossain et al. | Investigation of different materials as acetone sensors for application in type-1 diabetes diagnosis | |
| Liu et al. | Monitoring Apnea in the elderly by an electromechanical system with a carbon nanotube-based sensor | |
| Pariente | Silicon Nanowire Sensors Enable Diagnosis of PatientsviaExhaled Breath |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20190201 |
|
| WD01 | Invention patent application deemed withdrawn after publication |