CN109276295B - Lumbar puncture needle capable of measuring oxygen partial pressure and biochemical index of cerebrospinal fluid - Google Patents

Lumbar puncture needle capable of measuring oxygen partial pressure and biochemical index of cerebrospinal fluid Download PDF

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Publication number
CN109276295B
CN109276295B CN201810081102.9A CN201810081102A CN109276295B CN 109276295 B CN109276295 B CN 109276295B CN 201810081102 A CN201810081102 A CN 201810081102A CN 109276295 B CN109276295 B CN 109276295B
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needle
cerebrospinal fluid
partial pressure
oxygen partial
lumbar puncture
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CN201810081102.9A
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CN109276295A (en
Inventor
苏丹丹
梁成
杨志云
晏红
张燕菊
刘晓晓
郭莉琼
王国娟
王钦鹏
张红松
潘政
孙凤芹
武承凤
于利萍
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Lanzhou University
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Lanzhou University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/34—Trocars; Puncturing needles
    • A61B17/3401—Puncturing needles for the peridural or subarachnoid space or the plexus, e.g. for anaesthesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/34—Trocars; Puncturing needles
    • A61B17/3494—Trocars; Puncturing needles with safety means for protection against accidental cutting or pricking, e.g. limiting insertion depth, pressure sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/03—Measuring fluid pressure within the body other than blood pressure, e.g. cerebral pressure ; Measuring pressure in body tissues or organs
    • A61B5/032—Spinal fluid pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/03—Measuring fluid pressure within the body other than blood pressure, e.g. cerebral pressure ; Measuring pressure in body tissues or organs
    • A61B5/036—Measuring fluid pressure within the body other than blood pressure, e.g. cerebral pressure ; Measuring pressure in body tissues or organs by means introduced into body tracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6848—Needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B2010/0077—Cerebrospinal fluid

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

The utility model belongs to the field of medical appliances, and particularly relates to a lumbar puncture needle capable of measuring the oxygen partial pressure and biochemical indexes of cerebrospinal fluid, which comprises a needle head 1, a needle cylinder 2, a pushing component 3 and a guide wire 4. The needle head 1 is a hollow cavity, the scale 101 is arranged on the needle head 1, the pushing component 3 comprises a push rod 301 and a piston 302, the piston 302 is arranged in the needle cylinder 2, the needle head 1 is connected with the front end of the needle cylinder 2, and the front end of the needle cylinder 2 is provided with a movable cover 202. The lumbar puncture needle disclosed by the utility model can collect cerebrospinal fluid under the condition of isolating air, is simple and convenient to operate and safe to use, can achieve the purpose of accurately measuring oxygen partial pressure and biochemical indexes, and has the function of drug injection.

Description

Lumbar puncture needle capable of measuring oxygen partial pressure and biochemical index of cerebrospinal fluid
Technical Field
The utility model belongs to the field of medical appliances, and particularly relates to a lumbar puncture needle capable of measuring the oxygen partial pressure and biochemical indexes of cerebrospinal fluid.
Background
Lumbar puncture is one of the common operations in neurology, and is mainly used for extracting cerebrospinal fluid to measure pressure, injecting medicines into subarachnoid space, imaging cerebrospinal fluid, reserving cerebrospinal fluid specimen and the like, and clinically adopting the cerebrospinal fluid mode generally as follows: the patient typically performs a puncture in a lumbar and lateral recumbent position from the lumbar region 2 to the sacral region 1 (mainly lumbar regions 3-4). After local conventional disinfection and anesthesia, wearing rubber gloves, and slowly puncturing a puncture needle along the direction of spinous process and perpendicular to the back plane, wherein when the needle point encounters bone during needle insertion, the puncture needle is retracted to the subcutaneous angle to be corrected and then is punctured. When an adult inserts about 4-6cm (about 3-4cm of a child), the hard spinal film can be punctured to reach the subarachnoid space, part of the guide wire is extracted, whether cerebrospinal fluid flows out or not is observed, and the cerebrospinal fluid is slowly discharged (not more than 2-3 ml). After the operation is finished, the lumbar puncture needle is pulled out, covered with sterile gauze, fixed by adhesive tape, the patient is placed on the pillow for lying for 4-6 hours, and then the collected cerebrospinal fluid is used for measuring various biochemical indexes.
The oxygen partial pressure of cerebrospinal fluid refers to the strength of the physical dissolved oxygen in the cerebrospinal fluid, which reflects the degree of cerebral hypoxia and is also one of the important detection indexes of cerebrospinal fluid. However, the structural design of the cerebrospinal fluid collector or the liquid collector currently used has a plurality of defects: 1. the cerebrospinal fluid is exposed to the environment for a long time and is easy to be polluted by exogenous substances; 2. because the atmospheric pressure of the air is greater than the pressure of the cerebrospinal fluid, the atmospheric pressure can simultaneously make oxygen, carbon dioxide and the like in the air enter the cerebrospinal fluid when the air is contacted, so that the measurement value of the oxygen partial pressure of the cerebrospinal fluid is inaccurate, and a doctor obtains an incorrect diagnosis result, thereby influencing the subsequent treatment. Therefore, cerebrospinal fluid collected using conventional lumbar puncture needles is not suitable for measuring the partial pressure of oxygen in the cerebrospinal fluid.
In addition, researchers have attempted to improve the structure of lumbar puncture needles, but there are still some other drawbacks:
for example, the utility model patent "a lumbar puncture needle" (patent number CN 201210568499.7) can be used for measuring the pressure of cerebrospinal fluid and injecting medicine, the needle is fixed on the handle, and the observation window is arranged at the position of the transparent handle or the cavity of the handle to observe whether the cerebrospinal fluid flows out; after the needle head enters the human body, drainage is realized by rotating the valve handle threaded rod relative to the handle threaded through hole, and outflow of cerebrospinal fluid is accurately controlled. The device does not solve the following drawbacks of the conventional puncture needle: (1) the depth of insertion is inconvenient to grasp, and a doctor usually collects cerebrospinal fluid empirically; (2) the device for isolating air is not provided, a large amount of air components such as oxygen, carbon dioxide and the like can be mixed to a great extent, so that the measured oxygen partial pressure and other related data of biochemical indexes have great errors; (3) the pressure measuring device is in direct contact with cerebrospinal fluid, and the repeated use can cause pollution and inaccurate measurement results.
The utility model patent (novel lumbar puncture needle) (patent number CN 201220508634.4) can be used for measuring the pressure of cerebrospinal fluid, and the device comprises a puncture needle tube and a needle seat arranged at the rear end of the puncture needle tube, wherein the puncture depth can be accurately judged by the scale on the puncture needle tube; the device does not solve the following drawbacks of the conventional puncture needle: (1) lack of visual visibility to see if cerebrospinal fluid is flowing out; (2) the device for isolating air is not provided, a large amount of air components such as oxygen, carbon dioxide and the like can be mixed to a great extent, so that the measured oxygen partial pressure and related data of other biochemical indexes have great errors; (3) the pressure measuring device is in direct contact with cerebrospinal fluid, so that pollution can be caused by repeated use, and the measurement result is inaccurate; (4) the use is single, and the cerebrospinal fluid collecting device has no function of collecting cerebrospinal fluid and can be used for changing the fluid or injecting medicines.
However, there is no lumbar puncture needle dedicated to collecting cerebrospinal fluid in the market, so that the collected cerebrospinal fluid is kept in an initial state, accuracy of measurement results of various physiological and biochemical indexes is guaranteed, and it is difficult to meet requirements of medical diagnosis and treatment and market, so a new device is urgently needed to meet the requirements.
Disclosure of Invention
The utility model provides a lumbar puncture needle capable of solving the problems, namely, the lumbar puncture needle can directly observe whether cerebrospinal fluid flows out, can accurately grasp the puncture depth, can collect cerebrospinal fluid in a closed environment, can sense the pressure of the cerebrospinal fluid through a special material guide wire, and provides guidance for subsequent clinical diagnosis and treatment by observing the pressure. The lumbar puncture needle is simple to operate and convenient to use, and is mainly used for collecting cerebrospinal fluid which is not polluted by air under the condition of ensuring safety, so that the collected cerebrospinal fluid is kept in an initial state; can also be used for drug injection.
The technical scheme for solving the technical problems is as follows:
a lumbar puncture needle capable of measuring the oxygen partial pressure and biochemical index of cerebrospinal fluid comprises a needle head 1, a needle cylinder 2, a pushing component 3 and a guide wire 4; the needle head 1 is a hollow cavity, so that the guide wire 4 can be conveniently inserted and extracted; the needle cylinder 2 is made of transparent materials, the front end of the needle cylinder 2 is provided with a connector 201, the connector 201 is connected with the needle head 1, and an opening of the connector 201 can be matched with a liquid inlet of the oxygen partial pressure tester to prevent cerebrospinal fluid from leaking out and air from entering; the pushing component 3 is arranged in the needle cylinder 2, the pushing component 3 comprises a push rod 301 and a piston 302, one end of the push rod 301 is connected with the piston 302, and one end of the push rod 301 is exposed out of the rear end of the needle cylinder 2, so that the effects of isolating air, reserving a liquid storage space and facilitating liquid outflow during measurement are achieved; before puncture, the guide wire 4 penetrates through the pushing part 3 and penetrates through the cavity of the needle head 1, and the guide wire 4, the pushing part 3 and the needle head 1 are integrated, so that the inside of the lumbar puncture needle is isolated from air, and the cerebrospinal fluid collected later is ensured to keep an initial state.
Further, the guide wire 4 comprises a pressure measuring unit 401, a connecting part 402 and a plug 403, the plug 403 is arranged outside the syringe 2, the pressure measuring unit 401 is connected with the plug 403 through the connecting part 402, the pressure measuring unit 401 can tap an electric output signal from the plug 403 through the connecting part 402 when the detected cerebrospinal fluid pressure is detected, the plug 403 is externally connected with a pressure measurer to determine the pressure before collecting the cerebrospinal fluid, the safety of a patient is ensured, and guidance is provided for subsequent clinical diagnosis and treatment. The pressure measurement unit 401 may be a pressure measurement probe or a measurement diaphragm.
Furthermore, the needle cylinder 2 is provided with scales, so that the collected cerebrospinal fluid quantity and the dosage can be conveniently measured.
Further, the inner diameter of the needle head 1 is 0.184-1.283 mm, and compared with a common lumbar puncture needle, the inner diameter of the needle head 1 disclosed by the utility model is larger, so that sediment in cerebrospinal fluid is prevented from blocking the needle head.
Further, the outer diameter of the guide wire 4 is matched with the inner diameter of the cavity of the needle head 1, so that the extraction of the guide wire 4 is convenient while the air in the cavity of the needle head 1 is prevented from polluting cerebrospinal fluid.
Further, the movable cover 202 is arranged at the opening of the connector 201, so that after the collection is finished, the connector 201 can be covered by the movable cover 202, the cerebrospinal fluid in the syringe 2 is isolated from the outside, and the influence of the outside environment on the biochemical index of the cerebrospinal fluid and the oxygen partial pressure measurement result is avoided.
Further, the connector 201 is matched with the liquid inlet of the oxygen partial pressure tester, so that leakage of cerebrospinal fluid and air entering are prevented, and the accuracy of the biochemical index of the cerebrospinal fluid and the oxygen partial pressure measurement result is further ensured.
Further, the piston 302 is made of Kong Dan material, and when cerebrospinal fluid enters the inside of the syringe 2 to contact with the piston 302, the micropores are blocked by the cerebrospinal fluid, so that a closed space is formed inside the syringe 2, and the cerebrospinal fluid is ensured to keep an initial state.
Further, the needle head 1 is detachably connected with the connector 201 arranged at the front end of the needle cylinder 2, after cerebrospinal fluid is collected, the needle head 1 can be removed from the connector 201, and the connector opening 2 is connected with a measuring device, so that the measurement of oxygen partial pressure and biochemical indexes of the cerebrospinal fluid is facilitated.
Further, the needle 1 is provided with a scale 101, so that a medical staff can accurately grasp the puncture depth.
The medical staff can also replace the needle 1 with a common injection needle to perform drug injection.
The utility model has the beneficial effects that: the lumbar puncture needle capable of measuring the oxygen partial pressure and the biochemical index of the cerebrospinal fluid has the advantages of simple structure, convenient operation, direct observation of whether the cerebrospinal fluid flows out, accurate grasping of the puncture depth, and ensuring that the collected cerebrospinal fluid is kept in an initial state and is not polluted by air under the condition of ensuring the safety of a patient; the device also has the function of injecting medicine.
Drawings
Fig. 1 is a front view of the present utility model.
1-needle, 2-syringe, 202-flap, 3-pushing component, 301-push rod, 302-piston, 4-guide wire
Fig. 2 shows a front view of the needle 1 according to the utility model.
101-Scale
Fig. 3 is a front view of the utility model after surgery.
201-joint, 202-movable cover, 301-push rod, 302-piston
Fig. 4 is a schematic view of the structure of the guide wire 4 of the present utility model.
401 pressure measuring cell, 402 connection, 403 plug
DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION
The utility model is further described below with reference to the drawings and detailed description.
Example 1 lumbar puncture needle capable of measuring oxygen partial pressure and biochemical index of cerebrospinal fluid
A lumbar puncture needle capable of measuring the oxygen partial pressure and biochemical index of cerebrospinal fluid comprises a needle head 1, a needle cylinder 2, a pushing component 3 and a guide wire 4; the needle head 1 is a hollow cavity, and a scale 101 is arranged on the needle head 1; the inner diameter of the needle head 1 is 0.184mm-1.283mm; the needle cylinder 2 is made of transparent materials, the needle cylinder 2 is provided with scales, the front end of the needle cylinder 2 is provided with a connector 201, the connector 201 is connected with the needle head 1, and an opening of the connector 201 is matched with a liquid inlet of the oxygen partial pressure tester; the needle 1 is detachably connected with the front end of the syringe 2, and a movable cover 202 is arranged at the opening of the joint 201. The pushing component 3 is arranged in the needle cylinder 2, the pushing component 3 comprises a push rod 301 and a piston 302, one end of the push rod 301 is connected with one end of the piston 302, one end of the push rod 301 is exposed out of the rear end of the needle cylinder 2, and the piston 302 is made of Kong Dan material;
the guide wire 4 penetrates through the cavity of the needle head 1 through the pushing component 3, the outer diameter of the guide wire 4 is identical to the inner diameter of the cavity of the needle head 1, and the puncture guide wire 4, the pushing component 3 and the needle head 1 are integrated. The guide wire 4 comprises a pressure measuring unit 401, a connecting part 402 and a plug 403, wherein the plug 403 is arranged outside the needle cylinder 2, the pressure measuring unit 401 is connected with the plug 403 through the connecting part 402, the pressure measuring unit 401 can tap an electric output signal from the plug 403 through the connecting part 402 when the detected cerebrospinal fluid pressure is detected, and the plug 403 is externally connected with a pressure measurer to determine the pressure before the cerebrospinal fluid is collected. The pressure measurement unit 401 may be a pressure measurement probe or a measurement diaphragm. Example 2 method of Using lumbar puncture needle capable of measuring partial pressure of cerebrospinal fluid oxygen and Biochemical index
When the needle 1 is punctured in the direction of the spinous process, an adult is about 4-6cm (about 3-4cm of a child) to insert the needle, the depth of the needle is determined according to the scale 101 arranged on the needle 1, namely, the dura mater can be punctured to reach the subarachnoid space, part of the guide wire 4 is extracted, whether cerebrospinal fluid flows out or not is observed, the pressure of the cerebrospinal fluid is sensed by the guide wire 4 made of special materials immediately, and the plug 403 is externally connected with a pressure measurer to determine the pressure before the cerebrospinal fluid is collected; under the condition of ensuring the safety of a patient, the guide wire 4 is drawn out, the push rod 301 is slowly moved, the liquid storage space is adjusted, the cerebrospinal fluid collecting speed is controlled, the cerebrospinal fluid is slowly discharged, the volume of the cerebrospinal fluid is observed through the scales arranged on the needle cylinder 2, and after reaching 2-3ml, the push rod 301 is stopped moving.
After cerebrospinal fluid collection is finished, the lumbar puncture needle is pulled out, covered with sterile gauze, fixed by adhesive tape, and the patient is placed on the pillow for 4-6 hours. The joint of the needle head 1 and the front end of the needle cylinder 2 is disassembled, the movable cover 202 is timely buckled, and the needle cylinder 2 is sealed. The sealed needle cylinder 2 is taken out to measure the oxygen partial pressure of the cerebrospinal fluid, the movable cover 202 is opened, the connector 201 matched with the liquid inlet of the oxygen partial pressure measuring instrument is installed on the oxygen partial pressure measuring instrument, and the oxygen partial pressure of the cerebrospinal fluid is measured.
The technical scheme of the utility model can also be used for medicine injection, and medical staff can open the movable cover 202 to replace the needle 1 with a common injection needle to implement medicine injection under the condition that medicine needs to be injected to a patient through lumbar puncture.

Claims (9)

1. The lumbar puncture needle capable of measuring the oxygen partial pressure and biochemical indexes of cerebrospinal fluid comprises a needle head (1) and a guide wire (4), wherein the needle head (1) is a hollow cavity, and is characterized by further comprising a needle cylinder (2) and a pushing component (3); needle cylinder (2) adopts transparent material to make, and needle cylinder (2) front end is equipped with connects (201), connects (201) and is connected with syringe needle (1), and push unit (3) set up in needle cylinder (2), and push unit (3) are including push rod (301) and piston (302), and push rod (301) one end links to each other with piston (302), and push rod (301) one end exposes at needle cylinder (2) rear end, and seal wire (4) pass push unit (3) to run through the interior cavity of syringe needle (1), seal wire (4) constitute by pressure measurement unit (401), connecting portion (402), plug (403), pressure measurement unit (401) are connected with plug (403) through connecting portion (402), and plug (403) expose at needle cylinder (2) rear end.
2. The lumbar puncture needle capable of measuring the oxygen partial pressure and biochemical indexes of cerebrospinal fluid according to claim 1, wherein the needle cylinder (2) is provided with scales.
3. The lumbar puncture needle capable of measuring the oxygen partial pressure and biochemical index of cerebrospinal fluid according to claim 1, wherein the inner diameter of the needle (1) is 0.184mm-1.283mm.
4. The lumbar puncture needle capable of measuring the oxygen partial pressure and biochemical index of cerebrospinal fluid according to claim 1, wherein the outer diameter of the guide wire (4) is matched with the inner diameter of the cavity of the needle head (1).
5. The lumbar puncture needle capable of measuring the oxygen partial pressure and biochemical indexes of cerebrospinal fluid according to claim 1, wherein the opening of the connector (201) is provided with a movable cover (202).
6. The lumbar puncture needle capable of measuring the oxygen partial pressure and biochemical indexes of cerebrospinal fluid according to claim 1, wherein the opening of the connector (201) is matched with the liquid inlet of the oxygen partial pressure measuring instrument.
7. The lumbar puncture needle capable of measuring the oxygen partial pressure and biochemical index of cerebrospinal fluid according to claim 1, wherein said piston (302) is made of Kong Dan material.
8. The lumbar puncture needle capable of measuring the oxygen partial pressure and biochemical index of cerebrospinal fluid according to claim 1, wherein the needle head (1) is detachably connected with the front end of the needle cylinder (2).
9. The lumbar puncture needle capable of measuring the oxygen partial pressure and biochemical index of cerebrospinal fluid according to claim 1, wherein the needle (1) is provided with a scale (101).
CN201810081102.9A 2018-01-29 2018-01-29 Lumbar puncture needle capable of measuring oxygen partial pressure and biochemical index of cerebrospinal fluid Active CN109276295B (en)

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006111056A1 (en) * 2005-04-16 2006-10-26 Mingli He An invasive assembly for draining cerebro-spinal fluid
CN201200455Y (en) * 2008-05-16 2009-03-04 吕晓明 Y type arteriopuncture trocars with guide wire for preventing blood spraying externally
CN201492762U (en) * 2009-07-30 2010-06-02 谭友文 Syringe capable of guiding guide wires therein
CN104546030A (en) * 2013-10-12 2015-04-29 哈尔滨光凯科技开发有限公司 Cardiology department intervention device for preventing excessive bleeding
CN105561444A (en) * 2015-12-18 2016-05-11 青岛市市立医院 A new type of cardiovascular interventional therapy device
CN211131294U (en) * 2018-01-29 2020-07-31 兰州大学 A lumbar puncture needle capable of measuring cerebrospinal fluid oxygen partial pressure and biochemical indexes

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006111056A1 (en) * 2005-04-16 2006-10-26 Mingli He An invasive assembly for draining cerebro-spinal fluid
CN201200455Y (en) * 2008-05-16 2009-03-04 吕晓明 Y type arteriopuncture trocars with guide wire for preventing blood spraying externally
CN201492762U (en) * 2009-07-30 2010-06-02 谭友文 Syringe capable of guiding guide wires therein
CN104546030A (en) * 2013-10-12 2015-04-29 哈尔滨光凯科技开发有限公司 Cardiology department intervention device for preventing excessive bleeding
CN105561444A (en) * 2015-12-18 2016-05-11 青岛市市立医院 A new type of cardiovascular interventional therapy device
CN211131294U (en) * 2018-01-29 2020-07-31 兰州大学 A lumbar puncture needle capable of measuring cerebrospinal fluid oxygen partial pressure and biochemical indexes

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