CN109223728A - Capsule of red sage root and preparation method thereof - Google Patents
Capsule of red sage root and preparation method thereof Download PDFInfo
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- CN109223728A CN109223728A CN201811227801.6A CN201811227801A CN109223728A CN 109223728 A CN109223728 A CN 109223728A CN 201811227801 A CN201811227801 A CN 201811227801A CN 109223728 A CN109223728 A CN 109223728A
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- 240000007164 Salvia officinalis Species 0.000 title claims abstract description 59
- 239000002775 capsule Substances 0.000 title claims abstract description 53
- 238000002360 preparation method Methods 0.000 title claims abstract description 43
- 235000005412 red sage Nutrition 0.000 title claims abstract description 43
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 55
- 235000019441 ethanol Nutrition 0.000 claims abstract description 20
- 239000000284 extract Substances 0.000 claims abstract description 20
- 235000017276 Salvia Nutrition 0.000 claims abstract description 16
- 239000006071 cream Substances 0.000 claims abstract description 16
- 239000000843 powder Substances 0.000 claims abstract description 15
- 239000000047 product Substances 0.000 claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 238000000605 extraction Methods 0.000 claims abstract description 11
- 238000001291 vacuum drying Methods 0.000 claims abstract description 10
- 239000012141 concentrate Substances 0.000 claims abstract description 8
- 238000001914 filtration Methods 0.000 claims abstract description 8
- 238000010992 reflux Methods 0.000 claims abstract description 7
- 238000011049 filling Methods 0.000 claims abstract description 6
- 239000000314 lubricant Substances 0.000 claims abstract description 6
- 235000013409 condiments Nutrition 0.000 claims abstract description 5
- 238000002156 mixing Methods 0.000 claims abstract description 5
- 239000000706 filtrate Substances 0.000 claims abstract description 4
- 238000010438 heat treatment Methods 0.000 claims abstract description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 24
- 235000019359 magnesium stearate Nutrition 0.000 claims description 12
- 229920002472 Starch Polymers 0.000 claims description 10
- 239000008107 starch Substances 0.000 claims description 10
- 235000019698 starch Nutrition 0.000 claims description 10
- 238000000034 method Methods 0.000 abstract description 13
- 230000008569 process Effects 0.000 abstract description 9
- 230000000694 effects Effects 0.000 abstract description 6
- 230000008901 benefit Effects 0.000 abstract description 5
- 230000001737 promoting effect Effects 0.000 abstract description 3
- 239000000243 solution Substances 0.000 description 13
- 238000001035 drying Methods 0.000 description 10
- AIGAZQPHXLWMOJ-UHFFFAOYSA-N Tanshinone I Chemical compound C1=CC2=C(C)C=CC=C2C(C(=O)C2=O)=C1C1=C2C(C)=CO1 AIGAZQPHXLWMOJ-UHFFFAOYSA-N 0.000 description 7
- 239000000470 constituent Substances 0.000 description 6
- 239000003814 drug Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- IBGBGRVKPALMCQ-UHFFFAOYSA-N 3,4-dihydroxybenzaldehyde Chemical compound OC1=CC=C(C=O)C=C1O IBGBGRVKPALMCQ-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 150000007965 phenolic acids Chemical class 0.000 description 2
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 2
- PAFLSMZLRSPALU-MRVPVSSYSA-N (2R)-3-(3,4-dihydroxyphenyl)lactic acid Chemical compound OC(=O)[C@H](O)CC1=CC=C(O)C(O)=C1 PAFLSMZLRSPALU-MRVPVSSYSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 206010008479 Chest Pain Diseases 0.000 description 1
- PAFLSMZLRSPALU-QMMMGPOBSA-N Danshensu Natural products OC(=O)[C@@H](O)CC1=CC=C(O)C(O)=C1 PAFLSMZLRSPALU-QMMMGPOBSA-N 0.000 description 1
- 208000007201 Myocardial reperfusion injury Diseases 0.000 description 1
- PAFLSMZLRSPALU-UHFFFAOYSA-N Salvianic acid A Natural products OC(=O)C(O)CC1=CC=C(O)C(O)=C1 PAFLSMZLRSPALU-UHFFFAOYSA-N 0.000 description 1
- HYXITZLLTYIPOF-UHFFFAOYSA-N Tanshinone II Natural products O=C1C(=O)C2=C3CCCC(C)(C)C3=CC=C2C2=C1C(C)=CO2 HYXITZLLTYIPOF-UHFFFAOYSA-N 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 230000002785 anti-thrombosis Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000019636 bitter flavor Nutrition 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000000693 micelle Substances 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 229960003371 protocatechualdehyde Drugs 0.000 description 1
- AZEZEAABTDXEHR-UHFFFAOYSA-M sodium;1,6,6-trimethyl-10,11-dioxo-8,9-dihydro-7h-naphtho[1,2-g][1]benzofuran-2-sulfonate Chemical compound [Na+].C12=CC=C(C(CCC3)(C)C)C3=C2C(=O)C(=O)C2=C1OC(S([O-])(=O)=O)=C2C AZEZEAABTDXEHR-UHFFFAOYSA-M 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
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Abstract
The present invention relates to a kind of capsule of red sage root and preparation method thereof, which includes: step S1: taking red rooted salvia, adds the ethanol solution heating and refluxing extraction predetermined time of reservation amount；Step S2: being recovered by filtration ethyl alcohol, obtains concentrate and the dregs of a decoction；Step S3: being added the water of reservation amount in the dregs of a decoction, decocts the predetermined time；Step S4: filtration step S3 acquired solution merges filtrate with the concentrate of step S2, is concentrated under reduced pressure into relative density between the clear cream of 1.00~1.20g/mL；Step S5: add appropriate hydrophilicity condiment into the clear cream of step S4, crushed after vacuum drying, obtain capsule of red sage root extract powder；Step S6: after mixing by capsule of red sage root extract powder and moderate lubrication agent, filling capsule obtains finished product.Capsule of red sage root preparation method provided by the invention, simple process is easy to operate, cost price is low, has higher treatment curative effect, and promotional value is high, can produce better social and economic benefits simultaneously.
Description
Technical field
The present invention relates to chemicals medicine technical fields, and in particular to a kind of capsule of red sage root and preparation method thereof.
Background technique
Capsule of red sage root has the function of activating microcirculation and removing stasis medicinal, tranquilizing and allaying excitement, is usually used in thoracic obstruction caused by treating hemostasis impatency, symptoms include
Chest pain, sore spot are fixed, tongue fur is dark violet etc., the angina pectoris as caused by coronary heart disease, uncomfortable in chest and palpitaition etc., main pharmacodynamics ingredient
For Salvia root P.E, which contains water solubility and fat-soluble two classes active principle in red rooted salvia.Salvia root P.E is more
It is made into capsule form, content is brown color to dark brown coloured particles and powder；It is mildly bitter flavor, puckery.
Existing capsule of red sage root preparation method, exist following insufficient: (1) drying process be easy to cause determination system of thermal unstable material more
Degradation, causes loss of effective components；(2) drying property of water extract is poor；(3) the quality controlling of product is poor.
Therefore, capsule of red sage root preparation method urgently improves.
Summary of the invention
To solve the shortcomings of the prior art, the present invention provides a kind of preparation method of capsule of red sage root, including it is following
Step:
Step S1: taking red rooted salvia, adds the ethanol solution heating and refluxing extraction predetermined time of reservation amount；
Step S2: being recovered by filtration ethyl alcohol, obtains concentrate and the dregs of a decoction；
Step S3: the water of reservation amount being added into the dregs of a decoction, decocts the predetermined time；
Step S4: filtration step S3 acquired solution merges filtrate with the concentrate of step S2, is concentrated under reduced pressure at relatively close
Spend the clear cream between 1.00-1.20g/mL；
Step S5: add appropriate hydrophilicity condiment into the clear cream of step S4, crushed after vacuum drying, obtain capsule of red sage root medicinal extract
Powder；
Step S6: after mixing by capsule of red sage root extract powder and moderate lubrication agent, filling capsule obtains finished product.
Wherein, in the step S1, the ethanol solution being added is ethanol solution of the mass concentration between 85-95%, second
The additional amount of alcoholic solution and the mass ratio of red rooted salvia are between 8:1~10:1, and the time of refluxing extraction is between 1-2h；
In the step S3, the mass ratio of the water and the dregs of a decoction that are added is between 9:1~11:1, and decocting time is between 50-
70min；
In the step S4, the temperature of reduced pressure is between 60~80 DEG C；
In the step S5, the hydrophilicity condiment being added is starch, and vacuum drying temperature is between 60~80 DEG C；
In the step S6, the lubricant being added is magnesium stearate.
Wherein, in the step S1, the ethanol solution being added is the ethanol solution that mass concentration is 90%, ethanol solution
Additional amount and the mass ratio of red rooted salvia be 9:1, time of refluxing extraction is 1.5h；
In the step S3, the mass ratio of the water and the dregs of a decoction that are added is 10:1, and decocting time is 1 hour；
In the step S4, the temperature of reduced pressure is 70 DEG C；
In the step S5, vacuum drying temperature is 70 DEG C.
Wherein, in the step S5, the additional amount of starch and the mass ratio of clear cream are between 3:100-6:100.Wherein, described
In step S5, the additional amount of starch and the mass ratio of clear cream are 49:1000.
Wherein, in the step S6, the additional amount of magnesium stearate and the mass ratio of capsule of red sage root extract powder are between 1:2000-
3:2000.
Wherein, in the step S6, the additional amount of magnesium stearate and the mass ratio of capsule of red sage root extract powder are 1:1000.
Wherein, in the step S4, the relative density of gained clear cream is 1.10g/mL after reduced pressure.
Invention additionally provides a kind of capsule of red sage root, are prepared by any of the above-described preparation method.
Capsule of red sage root provided by the invention and preparation method thereof, simple process is easy to operate, cost price is low, has higher control
Curative effect is treated, promotional value is high, can produce better social and economic benefits simultaneously.
Detailed description of the invention
Fig. 1: the process flow chart of capsule of red sage root preparation method of the invention.
Specific embodiment
In order to have further understanding to technical solution of the present invention and beneficial effect, it is described in detail with reference to the accompanying drawing
Technical solution of the present invention and its beneficial effect of generation.
Fig. 1 is the process flow chart of capsule of red sage root preparation method of the invention, as shown in Figure 1, capsule of red sage root of the invention
Preparation method mainly includes the extraction of fat-soluble and water-soluble two effective constituents during effective component extracting, fat-soluble
The extraction of effective component is completed by the ethyl alcohol of high concentration, and the extraction of aqueous soluble active constituent is completed using aqueous solution, later
Remerging two kinds of effective components and being concentrated under reduced pressure is the medicinal extract with certain relative density, further obtains capsule finished product.
Specifically preparation manipulation step includes:
Step S1: taking red rooted salvia, adds the ethanol solution that 9 times of red rooted salvia quality of mass concentration is 90%, heats back
Stream extracts 1.5h；
Step S2: being recovered by filtration ethyl alcohol, obtains concentrate and the dregs of a decoction；
Step S3: the water that quality is 10 times of dregs of a decoction quality is added into the dregs of a decoction, decocts 1 hour；
Step S4: filtration step S3 acquired solution merges filtrate with the concentrate of step S2, at 70 DEG C be concentrated under reduced pressure at
Relative density is the clear cream of 1.10g/mL；
Step S5: add starch into the clear cream of step S4, crushed after being dried in vacuo at 70 DEG C, obtain capsule of red sage root extract powder；
The additional amount of starch and the mass ratio of clear cream are 49:1000.
Step S6: after mixing by capsule of red sage root extract powder and magnesium stearate, filling capsule obtains finished product, magnesium stearate
The mass ratio of additional amount and capsule of red sage root extract powder is 1:1000.
Invention additionally provides a kind of capsule of red sage root, are prepared by above-mentioned preparation method.
In conjunction with above-mentioned specific preparation step it is found that the preparation method of capsule of red sage root provided by the invention, main technique change
Into point, it is solved the technical issues of and generated have the beneficial effect that:
1, aiming at the problem that existing preparation method in the drying process degrade by determination system of thermal unstable material
Table 1 is the present invention Tanshinone I I dry for the crude product for being directed to same amount under different vacuum drying temperaturesADamage
The Orthogonal experiment results of consumption rate, by being analyzed orthogonal experiment data it is found that being dried in vacuo under 70 degrees Celsius, pellet
Join ketone IIAThe proportion of goods damageds it is minimum, therefore, by using vacuum drying process, ensure that can be had at 70 DEG C the present invention
The drying of effect, and can avoid a large amount of losses of effective component in the drying process, reduce the degradation to determination system of thermal unstable material, has
Benefit ensure that the quality of product.
| Drying temperature | Drying time (h) | Tanshinone I IAYield | Medicinal extract amount (%) | Tanshinone I IAThe proportion of goods damageds (%) |
| 60℃ | 16 | 0.490 | 24 | 46.5 |
| 70℃ | 9 | 0.493 | 25 | 44 |
| 80℃ | 6 | 0.452 | 23 | 52.7 |
| 90℃ | 4 | 0.408 | 25 | 53.6 |
2, for the problem of existing preparation method drying property difference
It is relatively tired when leading to dry due to containing the substances such as a large amount of polysaccharide and colloid in the water-soluble extractive of red rooted salvia
Difficulty, the present invention efficiently solve the problems, such as this, also, relative to existing by the way that hydroaropic substance starch is added in clear cream solution
Preparation process the addition manner of predetermined amount hydroaropic substance is added, the present invention pass through a large amount of comparative experiments, it is determined that most preferably
Addition ratio, the efficiency of drying process is utmostly improved on the basis of not influencing drug effect.
3, aiming at the problem that existing preparation method is not easy to fill
The present invention has selected magnesium stearate from many lubricants, and in view of the technique in filling micelle is convenient
Property and the drug effect of finished product etc., the mass ratio of additive amount and capsule of red sage root extract powder to magnesium stearate is defined, and is being guaranteed
On the basis of the content of finished product effective component, most useful for the filling of capsule product, in the magnesium stearate of the invention limited and its add
Obtained reagent sample on the basis of dosage, uniform color, good fluidity after mixing are easy to fill.
4, the problem more demanding to production equipment for existing preparation method
Inventor after comparing experiment to many technological parameters involved by entire preparation method by having found, in pellet
Join the extraction process by water stage of medicinal material, that is, in step S3, the quality and effective component of heating-up time of decoction process to finished capsule product
Content have no much influences, also, different equipment heating-up time difference and few, it is contemplated that heating rate is to production scale
More demanding with production equipment, the present invention is not strict with the heating-up time, only under the premise of considered critical decocting time,
It can guarantee the quality of finished product.
In the various finished product preparations of Radix Salviae Miltiorrhizae, the most common are the compound preparation of Radix Salviae Miltiorrhizae, the compound preparation of Radix Salviae Miltiorrhizae be there are no
The report of the adverse reaction for the preparation that single component Radix Salviae Miltiorrhizae is used as medicine, the present invention are used as medicine obtained corresponding preparations with single component Radix Salviae Miltiorrhizae,
Enrich the kind of red sage formulation.
The preparation method of the capsule of red sage root provided through the invention, can by the major part in red rooted salvia it is fat-soluble effectively at
Divide and aqueous soluble active constituent extract:
1, a large amount of tanshinone IIA is contained in the extracted fat-soluble effective component of the present invention, there is good anti-blood
Platelet aggregation, anti thrombotic action, also have protective effect to expeirmental myocardial ischemia and reperfusion injury.
2, the extracted aqueous soluble active constituent of the present invention contains a large amount of root of red-rooted salvia phenolic acid substance, (most such as salviandic acid A
Content is no less than 0.20mg in capsule made from end), it is tanshin polyphenolic acid B (content is no less than 13.0mg in final obtained capsule), red
Phenolic acid C, danshensu, protocatechualdehyde etc. have effects that good platelet aggregation-against and antithrombus formation, can improve micro-
It recycles and anti-oxidant.
3, the present invention extracts fat-soluble effective component and aqueous soluble active constituent simultaneously, and preparation is made, compared to more single
The only similar drug containing liposoluble constituent or water soluble ingredient, have better therapeutic effect.
To sum up, capsule of red sage root provided by the invention and preparation method thereof is led to using single red rooted salvia as the preparation that is used as medicine
The addition of suitable starch and magnesium stearate and the introducing of vacuum drying process are crossed, ensure that drying process and capsule subpackage
The technique convenience of process；It is simply easily grasped compared to more existing other capsule of red sage root preparations and preparation method, present invention process
Work, cost price is low, has higher treatment curative effect, and promotional value is high, while can generate preferable social benefit and economic effect
Benefit.
Although the present invention is illustrated using above-mentioned preferred embodiment, the protection model that however, it is not to limit the invention
It encloses, anyone skilled in the art are not departing within the spirit and scope of the present invention, and opposite above-described embodiment carries out various changes
It is dynamic still to belong to the range that the present invention is protected with modification, therefore protection scope of the present invention subjects to the definition of the claims.
Claims (9)
1. a kind of preparation method of capsule of red sage root, which comprises the following steps:
Step S1: taking red rooted salvia, adds the ethanol solution heating and refluxing extraction predetermined time of reservation amount；
Step S2: being recovered by filtration ethyl alcohol, obtains concentrate and the dregs of a decoction；
Step S3: the water of reservation amount being added into the dregs of a decoction, decocts the predetermined time；
Step S4: filtration step S3 acquired solution merges filtrate with the concentrate of step S2, and reduced pressure is situated between at relative density
In the clear cream of 1.00~1.20g/mL；
Step S5: add appropriate hydrophilicity condiment into the clear cream of step S4, crushed after vacuum drying, obtain capsule of red sage root extract powder；
Step S6: after mixing by capsule of red sage root extract powder and moderate lubrication agent, filling capsule obtains finished product.
2. the preparation method of capsule of red sage root as described in claim 1, it is characterised in that:
In the step S1, the ethanol solution that is added be mass concentration between 85~95% ethanol solution, ethanol solution plus
Enter the mass ratio of amount and red rooted salvia between 8:1~10:1, the time of refluxing extraction is between 1~2h；
In the step S3, the mass ratio of the water and the dregs of a decoction that are added is between 9:1~11:1, and decocting time is between 50~70min；
In the step S4, the temperature of reduced pressure is between 60~80 DEG C；
In the step S5, the hydrophilicity condiment being added is starch, and vacuum drying temperature is between 60~80 DEG C；
In the step S6, the lubricant being added is magnesium stearate.
3. the preparation method of capsule of red sage root as claimed in claim 2, it is characterised in that:
In the step S1, the ethanol solution being added is the ethanol solution that mass concentration is 90%, the additional amount of ethanol solution with
The mass ratio of red rooted salvia is 9:1, and the time of refluxing extraction is 1.5h；
In the step S3, the mass ratio of the water and the dregs of a decoction that are added is 10:1, and decocting time is 1 hour；
In the step S4, the temperature of reduced pressure is 70 DEG C；
In the step S5, vacuum drying temperature is 70 DEG C.
4. the preparation method of capsule of red sage root as described in claim 1, it is characterised in that: in the step S5, the addition of starch
The mass ratio of amount and clear cream is between 3:100-6:100.
5. the preparation method of capsule of red sage root as claimed in claim 4, it is characterised in that: in the step S5, the addition of starch
The mass ratio of amount and clear cream is 49:1000.
6. the preparation method of capsule of red sage root as described in claim 1, it is characterised in that: in the step S6, magnesium stearate
The mass ratio of additional amount and capsule of red sage root extract powder is between 1:2000-3:2000.
7. the preparation method of capsule of red sage root as claimed in claim 6, it is characterised in that: in the step S6, magnesium stearate
The mass ratio of additional amount and capsule of red sage root extract powder is 1:1000.
8. the preparation method of capsule of red sage root as described in claim 1, it is characterised in that: in the step S4, after reduced pressure
The relative density of gained clear cream is 1.10g/mL.
9. a kind of capsule of red sage root, it is characterised in that: be prepared by preparation method according to any one of claims 1 to 8.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811227801.6A CN109223728A (en) | 2018-10-22 | 2018-10-22 | Capsule of red sage root and preparation method thereof |
Applications Claiming Priority (1)
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Application publication date: 20190118 |