CN109200325A - A kind of preparation method of tack wound dressing - Google Patents
A kind of preparation method of tack wound dressing Download PDFInfo
- Publication number
- CN109200325A CN109200325A CN201811069601.2A CN201811069601A CN109200325A CN 109200325 A CN109200325 A CN 109200325A CN 201811069601 A CN201811069601 A CN 201811069601A CN 109200325 A CN109200325 A CN 109200325A
- Authority
- CN
- China
- Prior art keywords
- tack
- preparation
- wound dressing
- added
- anatase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Classifications
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
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- A—HUMAN NECESSITIES
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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- A61L15/42—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
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- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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- A61L15/42—Use of materials characterised by their function or physical properties
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of preparation methods of tack wound dressing, include: that will be seen that photocatalytic nanometer anti-biotic material, the mixed solvent being made of nonpolar solvent and polar solvent is distributed to by the block polymer that nonpolar segment and polarity segment form, composite solution is made；Composite solution is applied on release film again, is dried to obtain antibacterial soak layer；Pressure sensitive adhesive is applied on antibacterial soak layer, drying forms tack antibacterial soak layer；Finally sepage absorbing material is fixed on tack antibacterial soak layer, obtains the tack wound dressing of absorbable sepage, antibacterial moisture-inhibiting.The present invention prepares resulting Wound dressing with high water vapour permeability, and has long-acting anti-microbial property, effectively avoids wound infection；Absorbable wound exudate, and surface of a wound wet environment is maintained, promote wound healing, avoids the formation of scar；It can be directly adhered to skin surface, it is small to skin irritatin using simplicity.
Description
Technical field
The present invention relates to surface of a wound antibacterial isolated material technical fields, and in particular to a kind of preparation side of tack wound dressing
Method.
Background technique
Ideal Wound dressing should have the function of wound to be isolated, stops bacterium, control wound exudate, promote healing etc..With
The progress of science and technology, Wound dressing also develops to polymer thin film dressing, the dressing of sepage absorption-type, life by traditional natural gauze
The products such as object active dressing meet the diversity requirement of different type and the different phase surface of a wound.
Wet process healing theory thinks that the wet environment of wound surface facilitates the migration of epithelial cell, can accelerate wound
Healing.Have many advantages, such as that the dressing of sepage absorption function has absorb purulence blood and sepage, maintain surface of a wound wet environment, it is especially suitable
In Hard agglut wounds such as the moist surface of a wound, infective wound surfaces, and one of the developing direction of Wound dressing in the world.
The Chinese invention patent that authorization publication No. is 1046324 C of CN (application No. is 91109194.7) discloses one kind
Alginates fabric of high absorbent capacity and preparation method thereof, every gram of fabric absorbable 25 can deionized water or 19 grams of salt water, be applicable in
In Wound dressing and burn dressing.
Authorization publication No. is that the Chinese invention patent of CN 100336564C (application No. is 200510018241.X) discloses
A kind of burn dressing of chitin gel, crosslink density and porosity structure in gradient from top to bottom.The burn dressing has
Good water imbibition and biocompatibility, and have excellent mechanical performance, at any time with a variety of protecting wound surfaces and burn treating.
The Chinese invention patent that authorization publication No. is 104491914 B of CN (application No. is 201410826196.X) discloses
A kind of porous plural gel-nanofiber oxygen flow dressing and preparation method thereof, passes through the collagen egg for preparation method of electrostatic spinning
White nanofiber and two kinds of chitosan, alginic acid macromolecule polysaccharides are crosslinked to obtain plural gel, then by being freeze-dried
To mandruka-nanofiber double-layer composite material, there is good oxygen permeability, water imbibition, water penetration, penetrability and biofacies
Capacitive is suitable for a variety of surface of a wound such as the surface of a wound, burn, ulcer.
However above-mentioned Wound dressing does not have antibacterial effect, therefore the case where be easy to appear trauma surface infestation.And silver ion applies
Although material has good spectrum antibacterial effect, silver ion is readily migrate into the surface of a wound, inhibits wound healing instead, causes to create
Face pain.Therefore, this field develop novel antibacterial, water suction, moisture-inhibiting, oxygen flow Wound dressing can better meet the surface of a wound nursing
Specific demand.
Summary of the invention
The present invention provides a kind of preparation method of tack wound dressing, the Wound dressing of preparation is with high saturating
Wet performance and long-acting anti-microbial property.
A kind of preparation method of tack wound dressing, comprising the following steps:
(1) block polymer being made of nonpolar segment and polarity segment is distributed to molten by nonpolar solvent and polarity
The mixed solvent of agent composition, is made polymer solution；
(2) it will be seen that photocatalytic nanometer anti-biotic material is added in the polymer solution of (1) preparation, composite solution is made；
(3) composite solution made from (2) is applied on release film, forms composite solution wet film, obtains antibacterial after dry
Soak layer；
(4) medical pressure sensitive adhesive is applied on antibacterial soak layer made from (3), forms pressure sensitive adhesive wet film, it is dry to be formed certainly
Sticky antibacterial soak layer；
(5) sepage absorbing material is fixed on tack antibacterial soak layer made from (4), obtains absorbable sepage, resists
The tack wound dressing of bacterium moisture-inhibiting.
In the present invention, the block polymer, the visible light catalytic nano-antibacterial that are formed using nonpolar segment and polarity segment
The antibacterial soak layer of material composition, so that the Wound dressing of preparation has the function of efficient moisture-inhibiting, sustained anti-microbial, insulation blocking etc..
Wound dressing then can effectively be adhered to skin by medical pressure sensitive adhesive.Sepage absorbing material can then absorb sepage and maintain the surface of a wound damp
Wet environment.Release film is then used as backing material, i.e. peelable after dressing adheres to skin.
In step (1), the block polymer being made of nonpolar segment and polarity segment is distributed at -20~80 DEG C
In solvent, further preferably, the block polymer being made of nonpolar segment and polarity segment is distributed at 0~40 DEG C molten
In agent.
The monomer for forming the nonpolar segment of block polymer is styrene-ethylene, styrene-butadiene, styrene-second
One or more of alkene-butadiene section, butadiene, acrylic-butadiene, ethylene-propylene (including two kinds).Described is non-
The molecular weight of polarity segment is 800~200000 dalton.
The monomer for forming the polarity segment of block polymer is maleic anhydride, fumaric acid, 4- vinylbenzenesulfonic acid, 4- ethylene
One or more of base aniline (including two kinds).The molecular weight of the polarity segment is 500~2000 dalton.
Further preferably, the block polymer being made of nonpolar segment and polarity segment is styrene-Malaysia
The copolymer of acid anhydrides composition, the copolymer being made of styrene ethylene butadiene and 4- vinylbenzenesulfonic acid, by butadiene and
The block polymer of fumaric acid composition or the copolymer being made of styrene, butadiene and maleic anhydride.Wherein, using by fourth
The block polymer of diene and fumaric acid composition has very excellent high water vapor transmittance.
The preparation of the copolymer being made of styrene ethylene butadiene and 4- vinylbenzenesulfonic acid, comprising:
Under nitrogen protection, in 5~15 DEG C of reaction kettle, styrene ethylene butadiene copolymer is added to 1,2- bis-
In chloroethanes, stirring adds chlorosulfonic acid, is stirred to react 12~24 hours to dissolving, and ethanol precipitation washing is added, is drying to obtain
The copolymer being made of styrene ethylene butadiene and 4- vinylbenzenesulfonic acid.
Further preferably, in 10 DEG C of reaction kettle, 20 parts by weight of styrene-ethylene-butylene is total under nitrogen protection
Polymers is added to 80 parts by weight 1, and in 2- dichloroethanes, stirring adds 1 parts by weight chlorosulfonic acid, it is small to be stirred to react 18 to dissolving
When, the ethanol precipitation washing of 200 parts by weight is added, is drying to obtain by styrene ethylene butadiene and 4- vinylbenzenesulfonic acid group
At copolymer.
The preparation of the block polymer being made of butadiene and fumaric acid, comprising:
Under nitrogen protection, in 50 DEG C~70 DEG C of reaction kettle, liquid polybutadiene is added in 1,2- dichloroethanes,
Stirring adds fumaric acid and azodiisobutyronitrile, is stirred to react 16~30 hours to dissolving, and ethanol precipitation washing is added, does
The dry block polymer being made of to obtain the final product butadiene and fumaric acid；
Further preferably, under nitrogen protection, in 60 DEG C of reaction kettle, 16 parts by weight liquid polybutadienes are added to 85
Parts by weight 1, in 2- dichloroethanes, stirring is to dissolving.4 parts by weight fumaric acid and 0.1 parts by weight azodiisobutyronitrile are added, are stirred
Reaction 24 hours is mixed, the ethanol precipitation washing of 300 parts by weight is added, is drying to obtain and is gathered by the block that butadiene and fumaric acid form
Close object.
The preparation of the copolymer being made of styrene, butadiene and maleic anhydride, comprising:
Under nitrogen protection, in 70 DEG C~90 DEG C of reaction kettle, styrene-butadiene copolymer is added to 1,2- dichloro
In ethane, stirring adds maleic anhydride and azodiisobutyronitrile, is stirred to react 8~16 hours to dissolving, and ethanol precipitation is added
Washing, is drying to obtain the copolymer being made of styrene, butadiene and maleic anhydride；
Further preferably, under nitrogen protection, in 80 DEG C of reaction kettle, by 10 parts by weight of styrene-butadiene copolymer
(Yanshan Petrochemical SBS 1401) is added to 90 parts by weight 1, and in 2- dichloroethanes, stirring adds 1 parts by weight of maleic to dissolving
Acid anhydride and 0.1 parts by weight azodiisobutyronitrile, are stirred to react 10 hours, and the ethanol precipitation washing of 200 parts by weight is added, is drying to obtain
The copolymer being made of styrene, butadiene and maleic anhydride.
In the polymer solution mass percent of block polymer be 4%~20%, further preferably 8%~
12%.
In step (1), the mixed solvent by percent by volume 20%~80% nonpolar solvent and volume basis
Than 20%~80% polar solvent composition, further preferably, the solvent by percent by volume 40%~80% non-pole
Property solvent and percent by volume 20%~60% polar solvent composition, most preferably, the solvent is by percent by volume 60%
~70% nonpolar solvent and the polar solvent composition of percent by volume 30%~40%.
The nonpolar solvent is one or more of normal heptane, n-hexane, hexamethylene, hexahydrotoluene
(including two kinds), the polar solvent are ethyl alcohol, normal propyl alcohol, isopropanol, butanol, tetrahydrofuran, ethyl acetate, isopropyl acetate
One or more of ester (including two kinds).
In step (2), the visible light catalytic nano anti-biotic material is anatase titania, one in zinc oxide
Kind.
The partial size of the visible light catalytic nano anti-biotic material is 20~150nm, preferably 60~120nm.
The visible light catalytic nano anti-biotic material contains in the elements such as carbon, nitrogen, tungsten, iron, gold, platinum, cerium, nickel, copper, vanadium
One or more, preferably elements such as nitrogen, tungsten, carbon.
Further preferably, the visible light catalytic nano anti-biotic material is the anatase type nano dioxy containing nitrogen
Change titanium, the anatase-type nanometer titanium dioxide containing wolfram element or the anatase-type nanometer titanium dioxide containing carbon.
The mass percent of other elements is 0.5%~5% in the visible light catalytic nano anti-biotic material, preferably
0.5~3%.
The preparation of the anatase-type nanometer titanium dioxide containing nitrogen, comprising:
Butyl titanate and dehydrated alcohol are mixed, is added portionwise under stirring and is mixed by nitric acid, deionized water and dehydrated alcohol
Liquid continues to stir, obtains light yellow sol, and light yellow sol is dry, forges at lower 350 DEG C~450 DEG C of nitrogen atmosphere later
1h~3h is burnt, mills to obtain the anatase-type nanometer titanium dioxide containing nitrogen.
Further preferably, the butyl titanate of 10 parts by weight and the dehydrated alcohol of 90 parts by weight are mixed, lower point of strong stirring
It criticizes and is added by 1.5 parts by weight nitric acid, 1.5 parts by weight of deionized water and 8 parts by weight dehydrated alcohol mixed liquors, continue strong stirring
30min obtains light yellow sol, by light yellow sol in 75 DEG C of dry 12h, calcines 2h at lower 400 DEG C of nitrogen atmosphere later,
It mills to obtain the anatase-type nanometer titanium dioxide containing nitrogen.
The preparation of the anatase-type nanometer titanium dioxide containing wolfram element, comprising:
Titanium sulfate and sodium tungstate are added in deionized water in ptfe autoclave, stirring is to dissolving, later
8h~16h is reacted at 160 DEG C~200 DEG C, cooled and filtered is simultaneously washed with dehydrated alcohol, mills to obtain containing the sharp of wolfram element
Titanium ore type nano-titanium dioxide.
Further preferably, the sodium tungstate of the titanium sulfate of 10 parts by weight and 5 parts by weight is added in ptfe autoclave
It is added in the deionized water of 85 parts by weight, stirring reacts 12h to dissolving at 180 DEG C later, cooled and filtered and with anhydrous second
Alcohol washing, mills to obtain the anatase-type nanometer titanium dioxide containing wolfram element.
The preparation of the anatase-type nanometer titanium dioxide containing carbon, comprising:
Under nitrogen protection, graphene oxide is added in deionized water, is stirred until homogeneous, butyl titanate is added, is stirred
It mixes 1~3 hour, ethanol precipitation washing, 65 DEG C~85 DEG C dry 10h~14h, later in nitrogen atmosphere lower 350 DEG C~450 is added
1~3h is calcined at DEG C, mills to obtain the anatase-type nanometer titanium dioxide containing carbon.
Further preferably, under nitrogen protection, the graphene oxide of 5 parts by weight is added in 95 parts by weight of deionized water,
It is stirred until homogeneous, adds the butyl titanate of 10 parts by weight, be vigorously stirred 2 hours, the ethanol precipitation that 200 parts by weight are added is washed
It washs, 75 DEG C of dry 12h calcine 2h at lower 400 DEG C of nitrogen atmosphere later, mill to obtain the anatase type nano containing carbon
Titanium dioxide.
The mass percent of visible light catalytic nano anti-biotic material is 0.05%~1% in the composite solution, preferably
It is 0.05~0.4%.
In step (3), the release film is polyethylene release film, one in polyethylene terephthalate release film
Kind, preferably polyethylene terephthalate release film.
The release film is with a thickness of 20~100 μm, and preferably 25~40 μm.
The release film surface is coated with 0.1~0.2g/m2Silicone oil.
The composite solution wet film with a thickness of 100~400 μm, preferably 200~300 μm.
The temperature of the drying is 40~60 DEG C, and further preferably, the drying is in 40~60 DEG C of dry 1min
~3min.
In step (4), the pressure sensitive adhesive be one of aqueous polyacrylamide acid pressure sensitive adhesive, waterborne polyurethane pressure-sensitive adhesives,
Preferably aqueous polyacrylamide acid pressure sensitive adhesive.
The solid content of the pressure sensitive adhesive is 20~60%, preferably 40~50%.
The viscosity of the pressure sensitive adhesive is 100~2000cP, preferably 200~800cP.
The pressure sensitive adhesive wet-film thickness is 20~50 μm, preferably 30~40 μm.
The drying temperature of the pressure sensitive adhesive wet film is 60~90 DEG C, preferably 70~80 DEG C, further preferably, described
Dry is in 60~80 DEG C of dry 2~7min.
In step (5), the sepage absorbing material is alginates non-woven fabrics, chitosan non-woven fabrics, polyurethane foam, gathers
One of vinyl alcohol foam, preferably alginates non-woven fabrics and chitosan non-woven fabrics.
The sepage uptake of the sepage absorbing material is 400~6000g/m2。
The sepage absorbing material with a thickness of 0.5~3mm.
The Wound dressing of preparation has the function of antibacterial, water suction, moisture-inhibiting, oxygen flow etc..
Most preferably, a kind of preparation method of tack wound dressing, comprising the following steps:
(1) under nitrogen protection, in 60 DEG C of reaction kettle, by 16 parts by weight liquid polybutadienes (German Ying Chuan company,
Polyvest110) it is added to 85 parts by weight 1, in 2- dichloroethanes, stirring is to dissolving；Add 4 parts by weight fumaric acid and 0.1
Parts by weight azodiisobutyronitrile is stirred to react 24 hours, and the ethanol precipitation washing of 300 parts by weight is added, is drying to obtain by fourth two
The block polymer of alkene and fumaric acid composition；
(2) sodium tungstate of the titanium sulfate of 10 parts by weight and 5 parts by weight is added to 85 weights in ptfe autoclave
In the deionized water for measuring part, stirring reacts 12h to dissolving at 180 DEG C later, and cooled and filtered is simultaneously washed with dehydrated alcohol,
It mills to obtain the anatase-type nanometer titanium dioxide containing wolfram element；
(3) 10 parts by weight are weighed at 20 DEG C to be dispersed in by the copolymer that butadiene and fumaric acid form by percentage by volume
The in the mixed solvent of 70% hexamethylene and 30% isopropanol composition, is made the polymer solution of mass percent 10%；
(4) anatase-type nanometer titanium dioxide that 0.05 parts by weight contain wolfram element is weighed, the polymerization of step (3) is dispersed in
In object solution, composite solution is obtained；
(5) release film surface is coated with 0.15g/m2Silicone oil, by step (4) be made composite solution be applied to poly- terephthaldehyde
On sour glycol ester release film (the big southeast limited liability company in Zhejiang, DN508,30 μm), composite solution wet-film thickness is 200 μ
M, 50 DEG C of dry 1min obtain antibacterial soak layer；
(6) water soluble acrylic acid pressure sensitive adhesive (the good chemical inc of Shanghai Poly, BLJ-569) is applied to (5) system
On the antibacterial soak layer obtained, pressure sensitive adhesive wet-film thickness is 40 μm, and 80 DEG C of dry 2min form tack antibacterial soak layers；
(7) chitosan non-woven fabrics (Yangzhou Kai Ruite medical supplies Co., Ltd) is fixed to tack made from (6)
On antibacterial soak layer, the tack wound dressing of absorbable sepage, antibacterial moisture-inhibiting is obtained.
The tack antibacterial soak layer water vapour permeability of this method preparation is up to 2845.8g/ (m2For 24 hours), antibiotic property
It can be up to 99.9%, there is high water vapour permeability, and there is long-acting anti-microbial property.
Compared with prior art, the present invention has the advantage that
One, the Wound dressing that the present invention is prepared has high water vapour permeability, and has long-acting anti-microbial property, has
Effect avoids wound infection.
Two, the Wound dressing that the present invention is prepared can absorb wound exudate, and maintains surface of a wound wet environment, promotes wound
Healing, avoids the formation of scar.
Three, Wound dressing prepared by the present invention can be directly adhered to skin surface, small to skin irritatin using simplicity.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of tack wound dressing of the present invention.
Specific embodiment
In order to keep the object of the invention, technical solution, creation characteristic, effect clearer, present invention is further explained below.
Part appeared in embodiment is parts by weight.
Embodiment 1
(1) under nitrogen protection, in 10 DEG C of reaction kettle, by 20 parts of styrene ethylene butadiene copolymer (Ba Ling stones
Change, SEBS YH-503) it is added in 80 parts of 1,2- dichloroethanes, stirring adds 1 part of chlorosulfonic acid, is stirred to react 18 to dissolving
Hour, 200 parts of ethanol precipitation washing is added, is drying to obtain and is made of styrene ethylene butadiene and 4- vinylbenzenesulfonic acid
Copolymer.
(2) butyl titanate of 10 parts by weight and the dehydrated alcohol of 90 parts by weight are mixed at 20 DEG C, lower point of strong stirring
It criticizes and is added by 1.5 parts by weight nitric acid, 1.5 parts by weight of deionized water and 8 parts by weight dehydrated alcohol mixed liquors, continue strong stirring
30min obtains transparent light yellow sol.By colloidal sol in 75 DEG C of dry 12h, 2h is calcined at lower 400 DEG C of nitrogen atmosphere later,
It mills to obtain the anatase-type nanometer titanium dioxide containing nitrogen.
(3) copolymer point that 10g is made of styrene ethylene butadiene and 4- vinylbenzenesulfonic acid is weighed at 20 DEG C
It is dispersed in the in the mixed solvent being made of 70% hexamethylene of percentage by volume and 30% isopropanol, the poly- of mass percent 8% is made
Polymer solution；
(4) anatase-type nanometer titanium dioxide that 0.2g contains nitrogen is weighed, the polymer solution of step (3) is dispersed in
In, obtain composite solution；
(5) release film surface is coated with 0.15g/m2Silicone oil, by step (4) be made composite solution be applied to poly- terephthaldehyde
On sour glycol ester release film (the big southeast limited liability company in Zhejiang, DN508,30 μm), composite solution wet-film thickness is 200 μ
M, 50 DEG C of dry 1min obtain antibacterial soak layer.
(6) water soluble acrylic acid pressure sensitive adhesive (the good chemical inc of Shanghai Poly, BLJ-569) is applied to (5) system
On the antibacterial soak layer obtained, pressure sensitive adhesive wet-film thickness is 40 μm, and 80 DEG C of dry 2min form tack antibacterial soak layers；
(7) alginates non-woven fabrics (Yangzhou Kai Ruite medical supplies Co., Ltd) is fixed to tack made from (6)
On antibacterial soak layer, the tack wound dressing of absorbable sepage, antibacterial moisture-inhibiting is obtained.
Embodiment 2
(1) under nitrogen protection, in 60 DEG C of reaction kettle, by 16 parts by weight liquid polybutadienes (German Ying Chuan company,
Polyvest110) it is added to 85 parts by weight 1, in 2- dichloroethanes, stirring is to dissolving.Add 4 parts by weight fumaric acid and 0.1
Parts by weight azodiisobutyronitrile is stirred to react 24 hours, and the ethanol precipitation washing of 300 parts by weight is added, is drying to obtain by fourth two
The block polymer of alkene and fumaric acid composition.
(2) sodium tungstate of the titanium sulfate of 10 parts by weight and 5 parts by weight is added to 85 weights in ptfe autoclave
In the deionized water for measuring part, stirring reacts 12h to dissolving at 180 DEG C later, and cooled and filtered is simultaneously washed with dehydrated alcohol,
It mills to obtain the anatase-type nanometer titanium dioxide containing wolfram element.
(3) 10 parts by weight are weighed at 20 DEG C to be dispersed in by the copolymer that butadiene and fumaric acid form by percentage by volume
The in the mixed solvent of 70% hexamethylene and 30% isopropanol composition, is made the polymer solution of mass percent 10%；
(4) anatase-type nanometer titanium dioxide that 0.05 parts by weight contain wolfram element is weighed, the polymerization of step (3) is dispersed in
In object solution, composite solution is obtained；
(5) release film surface is coated with 0.15g/m2Silicone oil, by step (4) be made composite solution be applied to poly- terephthaldehyde
On sour glycol ester release film (the big southeast limited liability company in Zhejiang, DN508,30 μm), composite solution wet-film thickness is 200 μ
M, 50 DEG C of dry 1min obtain antibacterial soak layer.
(6) water soluble acrylic acid pressure sensitive adhesive (the good chemical inc of Shanghai Poly, BLJ-569) is applied to (5) system
On the antibacterial soak layer obtained, pressure sensitive adhesive wet-film thickness is 40 μm, and 80 DEG C of dry 2min form tack antibacterial soak layers；
(7) chitosan non-woven fabrics (Yangzhou Kai Ruite medical supplies Co., Ltd) is fixed to tack made from (6)
On antibacterial soak layer, the tack wound dressing of absorbable sepage, antibacterial moisture-inhibiting is obtained.
Embodiment 3
(1) copolymer (U.S. Cray Valley of the phenylethylene-maleic anhydride composition of 10 parts by weight is weighed at 20 DEG C
The SMA-EF-80 of company) it is dispersed in the in the mixed solvent being made of 60% hexahydrotoluene of percentage by volume and 40% isopropanol,
The polymer solution of mass percent 8% is made.
(2) under nitrogen protection, the graphene oxide of 5 parts by weight is added in 95 parts by weight of deionized water, is stirred to equal
It is even, the butyl titanate of 10 parts by weight is added, is vigorously stirred 2 hours, the ethanol precipitation washing of 200 parts by weight is added, 75 DEG C are dry
Dry 12h calcines 2h at lower 400 DEG C of nitrogen atmosphere later, mills to obtain the anatase-type nanometer titanium dioxide containing carbon.
(3) anatase-type nanometer titanium dioxide containing carbon for weighing 0.5 parts by weight is dispersed in the poly- of step (1)
In polymer solution, composite solution is obtained；
(4) release film surface is coated with 0.15g/m2Silicone oil, by step (3) be made composite solution be applied to poly- terephthaldehyde
On sour glycol ester release film (the big southeast limited liability company in Zhejiang, DN508,40 μm), composite solution wet-film thickness is 300 μ
M, 40 DEG C of dry 3min obtain antibacterial soak layer.
(5) water soluble acrylic acid pressure sensitive adhesive (the good chemical inc of Shanghai Poly, BLJ-569) is applied to (4) system
On the antibacterial soak layer obtained, pressure sensitive adhesive wet-film thickness is 30 μm, and 70 DEG C of dry 5min form tack antibacterial soak layers；
(6) alginates non-woven fabrics (Yangzhou Kai Ruite medical supplies Co., Ltd) is fixed to tack made from (5)
On antibacterial soak layer, the tack wound dressing of absorbable sepage, antibacterial moisture-inhibiting is obtained.
Embodiment 4
(1) under nitrogen protection, in 80 DEG C of reaction kettle, by 10 parts by weight of styrene-butadiene copolymer (Yanshan Petrochemical
SBS 1401) it is added to 90 parts by weight 1, in 2- dichloroethanes, stirring is to dissolving.Add 1 parts by weight maleic anhydride and 0.1 weight
Measure part azodiisobutyronitrile, be stirred to react 10 hours, be added 200 parts by weight ethanol precipitation washing, be drying to obtain by styrene,
The copolymer of butadiene and maleic anhydride composition.
(2) butyl titanate of 10 parts by weight and the dehydrated alcohol of 90 parts by weight are mixed at 20 DEG C, lower point of strong stirring
It criticizes and is added by 1.5 parts by weight nitric acid, 1.5 parts by weight of deionized water and 8 parts by weight dehydrated alcohol mixed liquors, continue strong stirring
30min obtains transparent light yellow sol.By colloidal sol in 75 DEG C of dry 12h, 2h is calcined at lower 400 DEG C of nitrogen atmosphere later,
It mills to obtain the anatase-type nanometer titanium dioxide containing nitrogen.
(3) weighed at 20 DEG C 10 parts by weight by the copolymer that styrene, butadiene and maleic anhydride form be dispersed in by
The in the mixed solvent of 60% normal heptane of percentage by volume and 40% normal propyl alcohol composition, the polymer that mass percent 12% is made are molten
Liquid；
(4) anatase-type nanometer titanium dioxide that 0.2 parts by weight contain nitrogen is weighed, the polymerization of step (3) is dispersed in
In object solution, composite solution is obtained；
(5) release film surface is coated with 0.15g/m2Silicone oil, by step (4) be made composite solution be applied to poly- terephthaldehyde
On sour glycol ester release film (the big southeast limited liability company in Zhejiang, DN508,25 μm), composite solution wet-film thickness is 300 μ
M, 60 DEG C of dry 1min obtain antibacterial soak layer.
(6) water soluble acrylic acid pressure sensitive adhesive (the good chemical inc of Shanghai Poly, BLJ-569) is applied to (5) system
On the antibacterial soak layer obtained, pressure sensitive adhesive wet-film thickness is 40 μm, and 60 DEG C of dry 7min form tack antibacterial soak layers；
(7) chitosan non-woven fabrics (Yangzhou Kai Ruite medical supplies Co., Ltd) is fixed to tack made from (6)
On antibacterial soak layer, the tack wound dressing of absorbable sepage, antibacterial moisture-inhibiting is obtained.
By " the ventilative film dressing water vapour of YYT 0471.2-2004 contact Wound dressing test method part 2 penetrates
Rate ", " photocatalysis antibacterial material and product anti-microbial property test method and evaluation under GBT 30706-2014 radiation of visible light " mark
Standard tests the water vapour permeability and anti-microbial property of 1~embodiment of embodiment 4, as a result as shown in the table.
The water vapour permeability and anti-microbial property of 1. embodiment sample of table
As shown in Figure 1, the tack wound dressing of absorbable sepage of the invention, antibacterial moisture-inhibiting, including release film 1, set
Set on release film 1 antibacterial soak layer 2, the pressure-sensitive adhesive layer 3 that is arranged on antibacterial soak layer 2 and be arranged on quick glue-line 3
Sepage absorbing material 4, antibacterial soak layer 2 and quick glue-line 3 form tack antibacterial soak layer.
Basic principles and main features of the invention and advantage of the invention has been shown and described above.The technology of the industry
Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and the above embodiments and description only describe this
The principle of invention, without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, these changes
Change and improvement is both fallen within the scope of claimed invention.Claimed scope of the invention appended claims and its equivalent
Object defines.
Claims (10)
1. a kind of preparation method of tack wound dressing, which comprises the following steps:
(1) block polymer being made of nonpolar segment and polarity segment is distributed to by nonpolar solvent and polar solvent group
At mixed solvent, polymer solution is made；
(2) it will be seen that photocatalytic nanometer anti-biotic material is added in the polymer solution of (1) preparation, composite solution is made；
(3) composite solution made from (2) is applied on release film, forms composite solution wet film, obtains antibacterial moisture-inhibiting after dry
Layer；
(4) medical pressure sensitive adhesive is applied on antibacterial soak layer made from (3), forms pressure sensitive adhesive wet film, drying forms tack
Antibacterial soak layer；
(5) sepage absorbing material is fixed on tack antibacterial soak layer made from (4), obtains tack wound dressing.
2. the preparation method of tack wound dressing according to claim 1, which is characterized in that described in step (1)
The block polymer being made of nonpolar segment and polarity segment is the copolymer that phenylethylene-maleic anhydride forms, by styrene-
Ethylene-butylene and 4- vinylbenzenesulfonic acid composition copolymer, the block polymer be made of butadiene and fumaric acid or
The copolymer being made of styrene, butadiene and maleic anhydride；
The mass percent of block polymer is 4%~20% in the polymer solution.
3. the preparation method of tack wound dressing according to claim 2, which is characterized in that described by styrene-
The preparation of copolymer of ethylene-butylene and 4- vinylbenzenesulfonic acid composition includes:
Under nitrogen protection, in 5~15 DEG C of reaction kettle, styrene ethylene butadiene copolymer is added to 1,2-, bis- chloroethene
In alkane, stirring adds chlorosulfonic acid, is stirred to react 12~24 hours to dissolving, and ethanol precipitation washing is added, is drying to obtain by benzene
The copolymer of ethylene-vinyl-butadiene and 4- vinylbenzenesulfonic acid composition；
The preparation of the block polymer being made of butadiene and fumaric acid includes:
Under nitrogen protection, in 50 DEG C~70 DEG C of reaction kettle, liquid polybutadiene is added in 1,2- dichloroethanes, is stirred
To dissolution, fumaric acid and azodiisobutyronitrile are added, is stirred to react 16~30 hours, ethanol precipitation washing is added, drying is
Obtain the block polymer being made of butadiene and fumaric acid；
The preparation of the copolymer being made of styrene, butadiene and maleic anhydride includes:
Under nitrogen protection, in 70 DEG C~90 DEG C of reaction kettle, styrene-butadiene copolymer is added to 1,2- dichloroethanes
In, stirring adds maleic anhydride and azodiisobutyronitrile, is stirred to react 8~16 hours to dissolving, and ethanol precipitation is added and washes
It washs, is drying to obtain the copolymer being made of styrene, butadiene and maleic anhydride.
4. the preparation method of tack wound dressing according to claim 1, which is characterized in that described in step (1)
Mixed solvent is by the nonpolar solvent of percent by volume 20%~80% and the polar solvent group of percent by volume 20%~80%
At；
The nonpolar solvent be one or more of normal heptane, n-hexane, hexamethylene, hexahydrotoluene, it is described
Polar solvent be one of ethyl alcohol, normal propyl alcohol, isopropanol, butanol, tetrahydrofuran, ethyl acetate, isopropyl acetate or two
Kind or more.
5. the preparation method of tack wound dressing according to claim 1, which is characterized in that described in step (2)
Visible light catalytic nano anti-biotic material is one of anatase titania, zinc oxide.
6. the preparation method of tack wound dressing according to claim 1, which is characterized in that described in step (2)
Visible light catalytic nano anti-biotic material is the anatase-type nanometer titanium dioxide containing nitrogen, the Detitanium-ore-type containing wolfram element
Nano-titanium dioxide or anatase-type nanometer titanium dioxide containing carbon.
7. the preparation method of tack wound dressing according to claim 6, which is characterized in that described contains nitrogen
Anatase-type nanometer titanium dioxide preparation, comprising:
Butyl titanate and dehydrated alcohol are mixed, are added portionwise under stirring by nitric acid, deionized water and dehydrated alcohol mixed liquor, after
Continuous stirring, obtains light yellow sol, and light yellow sol is dry, calcined at lower 350 DEG C~450 DEG C of nitrogen atmosphere later 1h~
3h mills to obtain the anatase-type nanometer titanium dioxide containing nitrogen；
The preparation of the anatase-type nanometer titanium dioxide containing wolfram element, comprising:
Titanium sulfate and sodium tungstate are added in deionized water in ptfe autoclave, stirring is to dissolving, later 160
DEG C~200 DEG C at react 8h~16h, cooled and filtered simultaneously washed with dehydrated alcohol, mills to obtain the anatase containing wolfram element
Type nano-titanium dioxide；
The preparation of the anatase-type nanometer titanium dioxide containing carbon, comprising:
Under nitrogen protection, graphene oxide is added in deionized water, is stirred until homogeneous, adds butyl titanate, stirring 1~
3 hours, ethanol precipitation washing, 65 DEG C~85 DEG C dry 10h~14h, later at lower 350 DEG C~450 DEG C of nitrogen atmosphere are added
1~3h is calcined, mills to obtain the anatase-type nanometer titanium dioxide containing carbon.
8. the preparation method of tack wound dressing according to claim 1, which is characterized in that described in step (2)
The mass percent of visible light catalytic nano anti-biotic material is 0.05%~1% in composite solution.
9. the preparation method of tack wound dressing according to claim 1, which is characterized in that described in step (3)
Release film is one of polyethylene release film, polyethylene terephthalate release film；
The composite solution wet film with a thickness of 100~400 μm；
The temperature of the drying is 40~60 DEG C.
10. the preparation method of tack wound dressing according to claim 1, which is characterized in that described in step (4)
Pressure sensitive adhesive be one of aqueous polyacrylamide acid pressure sensitive adhesive, waterborne polyurethane pressure-sensitive adhesives；
The pressure sensitive adhesive wet-film thickness is 20~50 μm；
The drying temperature of the pressure sensitive adhesive wet film is 60~90 DEG C.
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