CN109172713A - 一种治疗乙型肝炎、肝硬化、肝腹水、水肿的中药 - Google Patents

一种治疗乙型肝炎、肝硬化、肝腹水、水肿的中药 Download PDF

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CN109172713A
CN109172713A CN201811193997.1A CN201811193997A CN109172713A CN 109172713 A CN109172713 A CN 109172713A CN 201811193997 A CN201811193997 A CN 201811193997A CN 109172713 A CN109172713 A CN 109172713A
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刘钦
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Abstract

本发明涉及一种治疗乙型肝炎、肝硬化、肝腹水、水肿的中药及制备方法,属于中药制药领域,本发明药物包括:血风藤、茵陈蒿、白芍、鸡血藤、板蓝根、炒枳壳、

Description

一种治疗乙型肝炎、肝硬化、肝腹水、水肿的中药
技术领域
本发明涉及一种治疗乙型肝炎、肝硬化、肝腹水、水肿的中药及制备方法,属于中药制药领域。
背景技术
乙型肝炎、肝硬化、肝腹水、水肿,属中医学“黄疸”、“肋痛”、“肝郁”、“积聚”、“肝胃不和”、“痞块”、“鼓胀”等疾病的范畴。《灵枢.五邪篇》有:“邪在肝,则两肋中痛”。《素问.标本病传论》又有:“肝病头目眩,胁支满,三日体重身痛,五日而胀......”。《灵枢.水胀》论鼓胀谓:“腹胀身皆大,大与肤胀等也,色苍黄,腹筋起”。《难经》又有:“肝之积,名曰肥气,在左胁下,如覆杯”。现代医学治疗此类疾病大多是干扰素、拉米夫定、思替卡韦、肝制剂、三磷酸腺苷、肝泰乐、阿德福韦酯、益肝灵及维生素E等药物治疗,大多是治标不治本;而中医疗法则可以避免以上缺点。
发明内容
针对现有治疗乙型肝炎、肝硬化、肝腹水、水肿的技术存在的不足,本发明提供一种毒副作用小、治疗效果好、治愈率高、减少患者经济负担。本发明具有行气利水、活血化瘀、清热解毒、软坚散结、疏肝理气、清热祛湿、滋养肝肾之功效,对乙型肝炎、肝硬化、肝腹水、水肿有较好的疗效,可以起到保肝护肝的作用,能恢复肝功,能清除乙肝病毒,提高免疫力,表面抗原阳转阴,本发明适用于肝胆湿热型、肝血瘀阻型及肝肾阴虚性。
解决上述问题而采用的技术方案:(用量为重量份)
优选方案一:各组分的用量范围:
优选方案二:各组分的用量范围:(用量为重量份)
优选方案三:各组分的用量:(用量为重量份)
优选方案四:各组分的用量:(用量为重量份)
一种治疗乙型肝炎、肝硬化、肝腹水、水肿的中药,其特征在于:它有下列步骤制成:第一步选用药、炮制药:
(1)血风藤:本品为鼠李科植物翼核果的根茎,全年可采,洗净切片晒干;
(2)茵陈蒿:过筛,拣去杂质,除去残根,碾碎,再过筛去净泥屑;
(3)炒白芍:取白芍片,用文火炒至微黄色,取出放凉;
(4)鸡血藤:用水润透,切片,或蒸软后乘热切片,晒干;
(5)板蓝根:拣净杂质,洗净,润透,切片,晒干;
(6)麸炒枳壳:将锅烧热,撒入麦麸,待烟起投入枳壳片,不断翻动,炒至淡黄色时取出,筛去麦麸,放凉;
(7)虫:拣净杂质,以沸水洗净,文火焙干;
(8)醋柴胡:取柴胡片,加醋拌匀,稍闷,用文火炒干,取出放凉;
(9)八月札:洗净,稍浸,闷润至透,切片晒干,或洗净晒干;
(10)酒大黄:取大黄片或块,用黄酒喷淋拌匀,稍闷,用文火微炒,至色泽加深时,取出放凉;
(11)大腹皮:拣净杂质,碾轧使软,敲打,筛去泥屑;
(12)大金钱草:5月份采收,晒干用;
(13)冬瓜皮:食用冬瓜时,收集削下的外果皮,晒干;
(14)北沙参:拣去杂质,除去根茎,用水略洗,捞出,稍润,切段,晒干;
(15)半边莲:多于夏季采收,带根拔起,洗净,晒干或阴干;
(16)竹叶莲:洗净,晒干;
(17)醋延胡索:加醋与适量的水,用文火共煮至透心,水干时取出,切片晒干或晒干捣碎;
(18)盐杜仲:取杜仲丝或块,加盐水拌匀,润透,用中火炒至焦黑色,丝易断时,取出放凉;
(19)生牡蛎:取原药材,洗净,晒干,碾碎;
(20)鸡骨草:全年可采,取全株,除去荚果及杂质,晒干。
第二步:将血风藤、茵陈蒿、鸡血藤、板蓝根、大金钱草、半边莲、生牡蛎,加水过药面,先后煎煮三次,第一次药物沸腾后中火煎煮55-60分钟即可;第二次加水漫过药物,大火煎煮,药物沸腾后改为中火煎煮35-40分钟即可;
第三次加水漫过药物,大火煎煮沸腾后改为中火煎煮30-35分钟即可;将三次煎煮药液混合均匀后,过滤,加入2-2.2倍量95%乙醇,静置,过滤,弃去滤渣,取滤液;
第三步:将剩余中药分别称重、混合、拌匀,继而用粉碎机粉碎成细末,过100目筛,搅拌均匀,经灭菌杀毒后备用;
第四步:将滤液与药粉混合均匀后,加入95%乙醇调整湿度,并继续浓缩至稠膏状备用;
第五步:将上述湿颗粒再摄氏60-65度条件下干燥即可。
本发明药物服用方法:每次服用5-8g,一天两次,清晨6点钟空腹用温开水送服,然后卧床休息30分钟,服药后到中午12点钟不要吃任何食物,12点钟后吃淡面条,隔日吃一次淡面条,服药后有恶心呕吐现象,腹内有点疼痛,疼到肚肌旁就想大便,第一次稍稀一些,第二次、三、四次是稀水、粪沫和病积,12点后精神各方面慢慢好转,下午4点钟空腹用温开水送服,卧床休息30分钟。服药期间禁忌:忌食酱油、醋、辣椒、盐、碱、酒、肉、蒜、多吃蔬菜和水果,不吃面包和绿豆,经常保持情绪好,不吃豆腐和糕点、粉条、棉油、各种肉,男性患者忌床100天,病情若痊愈后,以下食物忌两年:南瓜、葡萄、金针花、猪头肉等。
本发明药物的特点,亦是对比现有技术的有益效果:1、纯中药制剂,毒副作用少;2、毒副作用少,无不良反应,不像西药治疗副作用大;3、药物来源于大自然,容易获得,药价低廉,减轻患者的经济负担;4、药物配方中各成分的不同的炮制方法,疗效有所不同;5、配方严谨合理,制作成本低廉。
药理作用:
血风藤:为鼠李科植物翼核果的根、茎,翼核果Ventilago Leiocarpa Benth.其功效:补益气血,祛风活络,治疗气血亏损,风湿疼痛,跌打损伤。
茵陈蒿:为菊科植物茵陈蒿的幼嫩茎叶,茵陈蒿Artemisia capillaris Thunb.茵陈蒿含有利胆作用的有效成分蒿属香豆精,即6,7-二甲氧基香豆精,味苦辛,凉,入肝脾膀胱经,其功效:清利湿热,治湿热黄疸,小便不利,风痒疮疖等。
白芍:为毛莨科植物芍药的根,芍药Paeonia lactiflora Pall.有抗菌作用,味苦酸,凉,入肝脾经,其功效:养血柔肝,缓中止痛,敛阴收汗,治胸腹胁肋疼痛,泻痢腹痛,自汗盗汗,阴虚发热等。
鸡血藤:为豆科植物米花豆、白花油麻藤、香花岩豆藤的藤茎,味苦甘,温,入心脾经,其功效:活血舒筋,治腰膝酸痛,麻木瘫痪,月经不调等。
板蓝根:味苦,性寒,入肝胃经,其功效:清热,解毒,凉血,治流感,流脑,乙脑,肺炎,丹毒,热毒发斑,疮疹等,具有抗菌抗病毒作用。
枳壳:为芸香科植物枸橘,味辛凉,入肺脾大肠经,其功效:坡起,行瘀,消积,治胸膈痰滞,胸痞,肋胀,食积等。
虫:味成寒,有毒,入心肝脾经,其功效:逐淤破积,通络理伤,治癥瘕积聚,血滞经闭,产后淤血腹痛,跌打损伤等,《长沙药解》:“虫善化瘀血,最补损伤……”。
柴胡:为伞形科植物北柴胡、狭叶柴胡等的根,抗病原体作用,味苦,凉,入肝胆经,其功效:和解表里,疏肝升阳,治寒热往来,胸满肋痛,口苦耳聋,头痛目眩等。
八月札:味甘,性寒,其功效:疏肝理气,活血止痛,除烦利尿,治肝胃气痛,胃热食呆,烦渴,赤白痢疾,腰痛,肋痛,疝气,痛经,子宫下垂等。
大黄:味苦,寒,入胃大肠肝经,其功效:具有泻下作用;具有抗菌作用;具有抗肿瘤作用;具有降血压作用;邪热毒,破积滞,行瘀血,治实热便秘,谵语发狂,食积痞满,痢疾初起,里急后重,瘀停经闭,癥瘕积聚,阳黄,水肿,淋浊,痈痒肿毒,疔疮,烫火伤等。
大腹皮:为棕榈科植物槟榔的果皮,味辛,微温,入脾胃大小肠经,其功效:下气宽中,行水,治脘腹痞胀,脚气,水肿,《本草纲目》:“降逆气,消肌肤中水气浮肿……”。《本草汇言》:“大腹皮,宽中利气之捷药也,方龙潭曰,主一切冷热之气上攻心腹,消上下水肿之气四体虚浮,下大肠壅滞之气二便不利,开关格痰饮之气阻塞不通,能疏通下泄,为畅达脏腑之剂。大腹皮轻浮,散无形之滞气,故痞满膨胀,水气浮肿,脚气壅逆者宜之,惟虚胀禁用,以其能泄真气也。”
大金钱草:为报春花科植物过路黄的全草或带根全草,味甘淡,平,其功效:清热,利湿,消肿,解毒,治黄疸,水肿,胆结石,肾结石、膀胱结石,反胃噎膈、跌打损伤、疔疮肿毒,具有治疗黄疸初起;治疗腹水肿胀;治肾虚水肿。
冬瓜皮:味甘凉,其功效:利水消肿,治疗水肿,腹泻,痈肿。药理:非肾性水肿恢复期患者内服冬瓜皮煎剂2两,并饮水1000毫升,在服药后2小时内排出尿量较对照组显著增加,2-4小时之间,则较对照组减少。
北沙参:为伞形科植物珊瑚的根,甘苦淡,凉,入肺脾经,养阴清肺,祛痰止咳,治肺热燥咳,虚劳久咳,阴伤咽干、口渴。
半边莲:为桔梗科植物半边莲的带根全草,药理作用:1、具有利尿作用,用药后不仅尿量增加,而且排氯量也大大增加,单位尿量中含氯浓度也超过正常水平,在利尿发生之前,一般有血液比重下降的现象,表明半边莲利尿在其直接作用于肾脏之前,还可能有肾外的利尿因素参与。味甘平,其功效:利水,消肿,解毒,治黄疸,水肿,臌胀等。治疗腹水,肾炎水肿,黄疸,水肿,小便不利。
竹叶莲:为鸭跖草科植物竹叶花的根茎或全草,根茎具有补肾养肾益阴,治腰疼,跌打损伤。
延胡索:为罂粟科植物延胡索的块茎,药理作用:止痛,有明显的止痛作用;催眠、镇静与安定作用;味辛苦,温,入胃甘经,其功效:活血,散瘀,理气,止痛,治心腹腰膝诸痛,月经不调,癥瘕,崩中,产后血晕,恶漏不净,跌打损伤。
杜仲:为杜仲科植物杜仲的树皮,药理作用:1、具有降压作用,2、具有利尿作用;味甘微辛温,入肝肾经,其功效:补肝肾,强筋骨,治腰肌酸痛,足膝痿弱,小便余沥,阴下湿痒,高血压。
牡蛎:味咸涩,凉,入肝肾经,其功效:敛阴,潜阳,止汗,涩精,化痰,软坚,治惊痫,眩晕,遗精,淋浊,崩漏,瘰疬,瘿瘤等。
鸡骨草:为豆科植物广东相思子的带根全草,味甘,凉,其功效:清热解毒,疏肝散淤,治黄疸肝炎,胃痛,乳痈,瘰疬,跌打损伤淤血疼痛。《南宁市药志》:“消炎解毒。治传染性肝炎,跌打驳骨。”广州部队《常用中草药手册》:“清热解毒,疏肝利湿,治急慢性肝炎,肝硬化,胃痛,小便刺痛,蛇咬伤。”全方配伍能促使行气利水、活血化瘀、清热解毒、软坚散结、疏肝理气、清热祛湿、滋养肝肾之功效,对乙型肝炎、肝硬化、肝腹水、水肿有较好的疗效,能清除乙肝病毒,提高免疫力,使表面抗原阳转阴,对引起的腹水、水肿也有较好消除作用。
临床资料与治疗方法:
从2012年05月01至2017年05月01日,本专科共治疗乙型肝炎、肝硬化、肝腹水、水肿患者800例,男性415例,女性385例;年龄最小者15岁,年龄最大者80岁;乙型肝炎患者280例;肝硬化患者160例;肝腹水患者180例;水肿患者180例。随机分为治疗组和对照组各400例,两组相比一般资料无显著性差异,具有可比性。治疗组使用本发明药物治疗;对照组给予干扰素、拉米夫定、思替卡韦、肝制剂、阿德福韦酯、三磷酸腺苷、肝泰乐、益肝灵及维生素E加减治疗,三个月为1个疗程,治愈的患者一般需2-5个疗程治愈。
中医症候判断标准:
肝胆湿热证:
主要症状:身目发黄、色泽鲜明、尿黄、苔黄腻;
次要症状:胁痛、口苦、恶心、厌油腻;
辩证要求:具备所有主症者,即属本证,具备主症中任意1项与次症中任意3项者,即属本证。
肝血瘀阻证:
主要症状:面色晦暗;肝掌;舌暗或有瘀斑;
次要症状:胁肋刺痛;胁下痞块;蜘蛛痣;舌下络脉青紫或曲张;
辩证要求:具备所有主症者,即属于本证,具备主症中任意2项与次症中任意2项,即属本证;具备主症中任意1项与次症中任意3项者,即属于本证者;具备所有次症者,即属于本证。
肝肾阴虚证
主要症状:腰膝酸软、目涩、舌红,少苔或无苔或有裂纹;
次要症状:胁肋隐痛、失眠多梦、耳鸣、手足心热、脉眩细;
辩证要求:具备所有主症者,即属于本证,具备主症中任意2项与次症中任意2项,即属本证;具备主症中任意1项与次症中任意3项者,即属于本证者;具备所有次症者,即属于本证。
肝腹水中医诊断:
气滞血瘀型
症状:腹大坚满、青筋暴露,胁下肿块刺痛,面色黧黑,皮肤可见丝纹状血痣,手掌赤痕,口干渴,但欲涑口而不咽下,大便色黑,唇色紫黑,舌质紫暗或有瘀斑,舌下静脉曲张,脉细涩。
湿热蕴结型
症状:腹大坚满,
中医症候疗效判定标准:
临床治愈:中医临床、体征消失或基本消失;
好转:中医临床症状、体征均有好转;
无效:中医临床症状、体征均无好转;
排除标准:
1、合并其它类型病毒性肝炎者,如丙型肝炎等;
2、其它非病毒性肝炎及引起的,如:酒精性肝硬化等;
3、因精神、语言等因素而资料收集者。
纳入标准:符合上述诊断标准的患者均符合。
两组疗效对比:
治疗组:400例乙型肝炎、肝硬化、肝腹水、水肿患者治疗结果如下表:
病例数 治愈 好转 无效 有效率
乙型肝炎 140 119 14 7 95%
肝硬化 80 25 35 20 75%
肝腹水 90 68 10 12 86.67%
水肿 90 80 4 6 93.33%
治疗组:治疗结果:治愈的119例患者有34例患者治愈时间为2个疗程;有52例患者治愈时间为3个疗程;有33例患者治愈时间为4个疗程;总有效率:88.75%,治愈率:73%。
对照组:400例乙型肝炎、肝硬化、肝腹水、水肿患者治疗结果如下表:
病例数 治愈 好转 无效 有效率
乙型肝炎 140 70 34 36 74.29%
肝硬化 80 20 29 31 61.25%
肝腹水 90 45 22 24 74.44%
水肿 90 50 23 17 81.11%
对照组:治疗结果:70例患者治愈时间为1个疗程的患者8例;治愈时间为2个疗程患者12例;治愈时间为3个疗程的患者14例;治愈时间为4个疗程的患者26例;治愈时间为5个疗程的患者为10例;总有效率:73.25%,治愈率:46.25%。
不良反应;患者治疗过程中,对照组出现身体不适和乏力,呼吸道敢染、头痛、腹部不适和腹痛、恶心、呕吐和腹泻等不良反应45例;治疗组未见明显不良反应。
二组治疗效果对比:
治疗组:总有效率:88.75%,治愈率:73%;对照组:总有效率:73.25%,治愈率:46.25%。
由对比结果可以看出本发明具有创造性。
具体实施方式
实施例1
解决上述问题而采用的技术方案:(用量为重量份)
一种治疗乙型肝炎、肝硬化、肝腹水、水肿的中药,其特征在于:它有下列步骤制成:第一步选用药、炮制药:
(1)血风藤:本品为鼠李科植物翼核果的根茎,全年可采,洗净切片晒干;
(2)茵陈蒿:过筛,拣去杂质,除去残根,碾碎,再过筛去净泥屑;
(3)炒白芍:取白芍片,用文火炒至微黄色,取出放凉;
(4)鸡血藤:用水润透,切片,或蒸软后乘热切片,晒干;
(5)板蓝根:拣净杂质,洗净,润透,切片,晒干;
(6)麸炒枳壳:将锅烧热,撒入麦麸,待烟起投入枳壳片,不断翻动,炒至淡黄色时取出,筛去麦麸,放凉;
(7)虫:拣净杂质,以沸水洗净,文火焙干;
(8)醋柴胡:取柴胡片,加醋拌匀,稍闷,用文火炒干,取出放凉;
(9)八月札:洗净,稍浸,闷润至透,切片晒干,或洗净晒干;
(10)酒大黄:取大黄片或块,用黄酒喷淋拌匀,稍闷,用文火微炒,至色泽加深时,取出放凉;
(11)大腹皮:拣净杂质,碾轧使软,敲打,筛去泥屑;
(12)大金钱草:5月份采收,晒干用;
(13)冬瓜皮:食用冬瓜时,收集削下的外果皮,晒干;
(14)北沙参:拣去杂质,除去根茎,用水略洗,捞出,稍润,切段,晒干;
(15)半边莲:多于夏季采收,带根拔起,洗净,晒干或阴干;
(16)竹叶莲:洗净,晒干;
(17)醋延胡索:加醋与适量的水,用文火共煮至透心,水干时取出,切片晒干或晒干捣碎;
(18)盐杜仲:取杜仲丝或块,加盐水拌匀,润透,用中火炒至焦黑色,丝易断时,取出放凉;
(19)生牡蛎:取原药材,洗净,晒干,碾碎;
(20)鸡骨草:全年可采,取全株,除去荚果及杂质,晒干。
第二步:将血风藤、茵陈蒿、鸡血藤、板蓝根、大金钱草、半边莲、生牡蛎,加水过药面,先后煎煮三次,第一次药物沸腾后中火煎煮55-60分钟即可;第二次加水漫过药物,大火煎煮,药物沸腾后改为中火煎煮35-40分钟即可;
第三次加水漫过药物,大火煎煮沸腾后改为中火煎煮30-35分钟即可;将三次煎煮药液混合均匀后,过滤,加入2-2.2倍量95%乙醇,静置,过滤,弃去滤渣,取滤液;
第三步:将剩余中药分别称重、混合、拌匀,继而用粉碎机粉碎成细末,过100目筛,搅拌均匀,经灭菌杀毒后备用;
第四步:将滤液与药粉混合均匀后,加入95%乙醇调整湿度,并继续浓缩至稠膏状备用;
第五步:将上述湿颗粒再摄氏60-65度条件下干燥即可。
本发明药物服用方法:每次服用5-8g,一天两次,清晨6点钟空腹用温开水送服,然后卧床休息30分钟,服药后到中午12点钟不要吃任何食物,12点钟后吃淡面条,隔日吃一次淡面条,服药后有恶心呕吐现象,腹内有点疼痛,疼到肚肌旁就想大便,第一次稍稀一些,第二次、三、四次是稀水、粪沫和病积,12点后精神各方面慢慢好转,下午4点钟空腹用温开水送服,卧床休息30分钟。服药期间禁忌:忌食酱油、醋、辣椒、盐、碱、酒、肉、蒜、多吃蔬菜和水果,不吃面包和绿豆,经常保持情绪好,不吃豆腐和糕点、粉条、棉油、各种肉,男性患者忌床100天,病情若痊愈后,以下食物忌两年:南瓜、葡萄、金针花、猪头肉等。
本发明药物的特点,亦是对比现有技术的有益效果:1、纯中药制剂,毒副作用少;2、毒副作用少,无不良反应,不像西药治疗副作用大;3、药物来源于大自然,容易获得,药价低廉,减轻患者的经济负担;4、药物配方中各成分的不同的炮制方法,疗效有所不同;5、配方严谨合理,制作成本低廉。
实施例2
解决上述问题而采用的技术方案:(用量为重量份)
本实施例的药物制造方法及使用方法和药物禁忌同实施例1相同。
本发明的实施例只用于说明本发明而非限制本发明,在不脱离本发明技术指导下,根据本领域普通技术知识,做出的各种替换和变更,均在本发明的保护范围内。

Claims (5)

1.一种治疗乙型肝炎、肝硬化、肝腹水、水肿的中药,其特征在于由以下重量份配比的原料制成:(用量为重量份)
2.按照权利要求1所述的一种治疗乙型肝炎、肝硬化、肝腹水、水肿的中药,其特征在于由以下配比的原料制成:(用量为重量份)
3.按照权利要求1或2所述的一种治疗乙型肝炎、肝硬化、肝腹水、水肿的中药,其特征在于由以下配比的原料制成:(用量为重量份)
4.按照权利要求1或2或3所述的一种治疗乙型肝炎、肝硬化、肝腹水、水肿的中药,其特征在于由以下配比的原料制成:(用量为重量份)
5.按照权利要求1或2或3所述的一种治疗乙型肝炎、肝硬化、肝腹水、水肿的中药,其特征在于:它有下列步骤制成:第一步选用药、炮制药:
(1)血风藤:本品为鼠李科植物翼核果的根茎,全年可采,洗净切片晒干;
(2)茵陈蒿:过筛,拣去杂质,除去残根,碾碎,再过筛去净泥屑;
(3)炒白芍:取白芍片,用文火炒至微黄色,取出放凉;
(4)鸡血藤:用水润透,切片,或蒸软后乘热切片,晒干;
(5)板蓝根:拣净杂质,洗净,润透,切片,晒干;
(6)麸炒枳壳:将锅烧热,撒入麦麸,待烟起投入枳壳片,不断翻动,炒至淡黄色时取出,筛去麦麸,放凉;
(7)虫:拣净杂质,以沸水洗净,文火焙干;
(8)醋柴胡:取柴胡片,加醋拌匀,稍闷,用文火炒干,取出放凉;
(9)八月札:洗净,稍浸,闷润至透,切片晒干,或洗净晒干;
(10)酒大黄:取大黄片或块,用黄酒喷淋拌匀,稍闷,用文火微炒,至色泽加深时,取出放凉;
(11)大腹皮:拣净杂质,碾轧使软,敲打,筛去泥屑;
(12)大金钱草:5月份采收,晒干用;
(13)冬瓜皮:食用冬瓜时,收集削下的外果皮,晒干;
(14)北沙参:拣去杂质,除去根茎,用水略洗,捞出,稍润,切段,晒干;
(15)半边莲:多于夏季采收,带根拔起,洗净,晒干或阴干;
(16)竹叶莲:洗净,晒干;
(17)醋延胡索:加醋与适量的水,用文火共煮至透心,水干时取出,切片晒干或晒干捣碎;
(18)盐杜仲:取杜仲丝或块,加盐水拌匀,润透,用中火炒至焦黑色,丝易断时,取出放凉;
(19)生牡蛎:取原药材,洗净,晒干,碾碎;
(20)鸡骨草:全年可采,取全株,除去荚果及杂质,晒干。
第二步:将血风藤、茵陈蒿、鸡血藤、板蓝根、大金钱草、半边莲、生牡蛎,加水过药面,先后煎煮三次,第一次药物沸腾后中火煎煮55-60分钟即可;第二次加水漫过药物,大火煎煮,药物沸腾后改为中火煎煮35-40分钟即可;
第三次加水漫过药物,大火煎煮沸腾后改为中火煎煮30-35分钟即可;将三次煎煮药液混合均匀后,过滤,加入2-2.2倍量95%乙醇,静置,过滤,弃去滤渣,取滤液;
第三步:将剩余中药分别称重、混合、拌匀,继而用粉碎机粉碎成细末,过100目筛,搅拌均匀,经灭菌杀毒后备用;
第四步:将滤液与药粉混合均匀后,加入95%乙醇调整湿度,并继续浓缩至稠膏状备用;
第五步:将上述湿颗粒再摄氏60-65度条件下干燥即可。
CN201811193997.1A 2018-10-03 2018-10-03 一种治疗乙型肝炎、肝硬化、肝腹水、水肿的中药 Withdrawn CN109172713A (zh)

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CN1895626A (zh) * 2006-06-13 2007-01-17 周鄂龙 一种治疗肝病的中药
CN101766720A (zh) * 2010-01-22 2010-07-07 吴清军 一种治疗肝病的药物
CN101890146A (zh) * 2010-08-03 2010-11-24 赵云龙 一种治疗肝病的中药丸剂
CN107095996A (zh) * 2016-02-22 2017-08-29 杨金禄 一种中药保肝组合物

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1895626A (zh) * 2006-06-13 2007-01-17 周鄂龙 一种治疗肝病的中药
CN101766720A (zh) * 2010-01-22 2010-07-07 吴清军 一种治疗肝病的药物
CN101890146A (zh) * 2010-08-03 2010-11-24 赵云龙 一种治疗肝病的中药丸剂
CN107095996A (zh) * 2016-02-22 2017-08-29 杨金禄 一种中药保肝组合物

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