CN109156895A - A kind of reduction cigarette smoking dry sensation and irritating filter stick additive, preparation method and the usage - Google Patents
A kind of reduction cigarette smoking dry sensation and irritating filter stick additive, preparation method and the usage Download PDFInfo
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- CN109156895A CN109156895A CN201810891586.3A CN201810891586A CN109156895A CN 109156895 A CN109156895 A CN 109156895A CN 201810891586 A CN201810891586 A CN 201810891586A CN 109156895 A CN109156895 A CN 109156895A
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- cigarette
- yunnan
- additives
- fruit
- radix glycyrrhizae
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- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
- A24D3/00—Tobacco smoke filters, e.g. filter-tips, filtering inserts; Filters specially adapted for simulated smoking devices; Mouthpieces for cigars or cigarettes
- A24D3/06—Use of materials for tobacco smoke filters
- A24D3/14—Use of materials for tobacco smoke filters of organic materials as additive
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
- A24D3/00—Tobacco smoke filters, e.g. filter-tips, filtering inserts; Filters specially adapted for simulated smoking devices; Mouthpieces for cigars or cigarettes
- A24D3/04—Tobacco smoke filters characterised by their shape or structure
- A24D3/048—Tobacco smoke filters characterised by their shape or structure containing additives
Abstract
The invention discloses a kind of additives of filter tip, including following mass component: Yunnan Ji Yi fruit and snow mountain Radix Glycyrrhizae mixed extract are 20-30wt%, Megastigmatrienone is 0.1-0.15wt%, Bronyl acetate is 0.2-0.3wt%, geranyl acetate 0.2-0.3wt%, Tween-80 0.5-1wt%, Fructus Perillae quintessence oil is 0.2-0.4wt%, chrysanthemum concrete is 1.5-2wt%, essential oil of tobaccos 1.5-2wt%, kudzu root extract 0.2-0.5wt%；Its surplus is triacetyl glycerine.The invention also discloses the extracting methods and the additives of filter tip of the Yunnan Ji Yi fruit and snow mountain Radix Glycyrrhizae mixed extract for reducing cigarette smoking dry sensation and irritating purposes.
Description
Technical field
The invention belongs to cigarette additive technical fields, are specifically related to a kind of with reduction cigarette smoking dry sensation and thorn
Swash filter stick additive, the preparation method and the usage of property.
Background technique
Filter tip has become indispensable a part in cigarette, and is also advancing.Since 2 months in 2005
The Framework Convention on Tobacco Control of the World Health Organization comes into force, and global tobacco control activity increasingly increases, and people's health consciousness is also big
Big enhancing.The function of filter tip has had exceeded the function of initially decorating, and becoming reduces cigarette smoke tar and special nocuousness
The important means of ingredient.
But it is necessarily accompanied with cigarette flavor loss while lowering harm and decreasing coking and comfort level is deteriorated, the research and development of perfuming cigarette charging
And application is just becoming one of the most key technology that cigarette flavor and taste is kept in lowering harm and decreasing coking work.In numerous perfuming cigarettes
In technology, filter tip flavoring is also an important flavoring mode, during can avoid cigarette storage by filter tip flavoring and burn and suck
Fragrance escape and be pyrolyzed and the quiet combustion of cigarette during added flavors and fragrances decomposition and loss.
Yunnan tobacco product fragrance is sufficient, strong, and strength is moderate, and suction satisfaction is strong.Since consumer taste is liked
Otherness, partially, there is dry sensations in market outside the province that slightly strong, irritation slightly appears, aspirates comfort slightly for part cigarette product
The problem of shortcoming.Therefore very urgent to the relevant technologies demand for reducing cigarette smoking irritation and improvement suction comfort.This
Invention part Yunnan tobacco product there are aiming at the problem that, having developed one kind can effectively reduce cigarette dry sensation and irritation, mention
Rise the additives of filter tip of cigarette suction comfort.
Summary of the invention
In view of the above-mentioned deficiencies in the prior art, it is an object of the present invention to provide a kind of glyceryl triacetate-glycerol-ethyl alcohol
Mixed solvent extracts Yunnan Ji Yi fruit and snow mountain Radix Glycyrrhizae sample, adds other functional components in extracting solution, is deployed into cigarette filter
Mouth additive, the additive are added in cigarette filter in cigarette filter forming process by plasticizer, can effectively reduce volume
Cigarette dry sensation and irritation improve cigarette suction comfort.
The purpose of the present invention is achieved by the following technical programs.
Unless otherwise indicated, percentage of the present invention is weight percent.
A, the extraction of Yunnan Ji Yi fruit and snow mountain Radix Glycyrrhizae sample
The root 3:2-4:1 in mass ratio mixing of Yunnan Ji Yi fruit and snow mountain Radix Glycyrrhizae drying after vacuum drying, is crushed to 10-
20 mesh obtain material sample, and material sample is fitted into extractor, and the mixed solvent of 5-8 times of material sample sample quality is added,
Mixed solvent is the triacetyl glycerine that mass ratio is 80:10:10: glycerol: alcohol mixture；Then under 80-100 DEG C of stirring
Refluxing extraction 2.0-3.0 hours, mixing speed 2 was 80-120 revs/min.Filter bag filters pressing is used after the completion of extracting, and obtains extracting solution
And filter residue, 1.8-2.2 times of sample quality of ethanol washing filter residue is used again, and cleaning solution is then obtained by filtration；Combined extract and
Cleaning solution boils off ethyl alcohol in 90-100 DEG C of decompression, can must obtain the three of the Yunnan Ji Yi fruit and snow mountain Radix Glycyrrhizae mixed extract
Acetoglyceride and glycerite.
B, the preparation of cigarette dry sensation and irritation additives of filter tip is reduced
The irritating additives of filter tip of reduction cigarette of the present invention, is made: Yunnan of the raw material of following mass percents
Ji Yi fruit and snow mountain Radix Glycyrrhizae mixed extract are 20-30wt%, Megastigmatrienone 0.1-0.15wt%, and Bronyl acetate is
0.2-0.3wt%, geranyl acetate are 0.2-0.3 problem %, Tween-80 0.5-1wt%, Fructus Perillae quintessence oil 0.2-
0.4wt%, chrysanthemum concrete 1.5-2wt%, essential oil of tobaccos 1.5-2wt%, kudzu root extract 0.2-0.5wt%；Its surplus
For triacetyl glycerine.Each raw material is uniformly mixed to obtained light yellow liquid, as required cigarette filter-tip additive agent.It is described
Yunnan Ji Yi fruit and snow mountain Radix Glycyrrhizae mixed extract are the three of Yunnan Ji Yi fruit and snow mountain Radix Glycyrrhizae mixed extract that step A obtains
The solution of acetoglyceride and glycerol.
Additive of the present invention raw material based on Yunnan Ji Yi fruit and snow mountain Radix Glycyrrhizae mixed extract.Yunnan Ji Yi
Fruit Yunnan also known as Ji Yi fruit, acid Ji Yi are Qiang Wei section rose.Organic acid rich in the fruit, have it is tempting
Sour taste；Its extract can increase the sour of cigarette smoke, reduce cigarette smoking irritation；Snow mountain Radix Glycyrrhizae is Lamiaceae plant
The dry root of false gentianae macrophyllae is diterpene glycoside compound containing high sweet substance baiyunoside, and sugariness is 600 times of sucrose, and
Sweet taste can be kept 1 hour or more, be ideal natural sweetener, can effectively promote the sweet sense of cigarette smoking.
In other auxiliary elements: glycerol and Tween-80 are cosolvent and fixastive, and glycerol can increase sample in extraction process
The dissolution of middle polar acidic ingredient, increases the solubility of acid ingredient；The fragrance component of Tween-80 in formula keeps stablizing,
Also have the function of humectation, the moisture stabilization of volume cigarette filter can be balanced after addition, increases the moisture feeling of cigarette smoking.
Megastigmatrienone is the important fragrance component of tobacco, can make the miscellaneous of the softer plentiful cover flue gas of cigarette smoking fragrance
Taste.Bronyl acetate has refrigerant pine fragrance, can increase the cool sense of taste of cigarette smoking.Geranyl acetate has graceful
Rose and lavender fragrance, can assign cigarette smoke floral character.
Fructus Perillae quintessence oil, lophatherum gracile absolute oil, pure tobacco oil and chrysanthemum concrete are natural plant extracts.Fructus Perillae quintessence oil has dense
The strong distinctive faint scent of fragrant purple perilla, and with happy herbal and nut fragrance, fragrance texture is thick and heavy.Lophatherum gracile absolute oil has distinctness
Lophatherum gracile fragrance, moistening lung and producing body fluid effect is prominent.Chrysanthemum concrete has the strong distinctive faint scent of chrysanthemum, refrigerant, decompression, clear
Pharynx, the effect of moistening lung are prominent.Pure tobacco oil is rich in a large amount of this perfume of tobacco ingredients, can increase this perfume of the tobacco of cigarette smoking, covers
Miscellaneous gas.
Kudzu root extract is the crude extract rich in isoflavones prepared by raw material of Radix Puerariae, and total isoflavone content exists
70wt% or so, the extract have outstanding anti-oxidant and antibacterial activity, using can prevent additive from aoxidizing in additive
It is rotten and putrid and deteriorated.Furthermore isoflavone compound, which is also important, improves sense of taste ingredient, can also increase the profit of cigarette smoking
Sense promotes suction comfort.
C, the biological assessment of cigarette dry sensation and irritation additives of filter tip is reduced
Using cell aquaporin 5 (AQP5) construct drop it is dry promote the production of body fluid model to drop additives of filter tip of the present invention into
Row evaluation.Salivary acinar cells are subjected to medical preconditioning first, it is made to simulate cell micro-environment when dry syndrome occurs,
Cell is stimulated using various concentration additives of filter tip again, the cells are fixed after stimulation, AQP5 penetrating, that FITC label is added
Antibody carries out dye marker, with high intension imaging system observation additives of filter tip treated cell AQP5 expressing quantity,
And compared with the cell controls handled without additives of filter tip.The result shows that: additives of filter tip of the present invention can raise cell
AQP5 expressing quantity illustrates that it has good effect of promoting the production of body fluid, and can promote the moisture feeling of cigarette smoking, reduces dry sensation and stimulation
Property.
D, filter tip addition and cigarette preparation
The present invention is that cigarette filter forms most common plasticizer, and addition of the invention in view of triacetyl glycerine
Agent be using triacetyl glycerine as medium (95wt% or more that triacetyl glycerine accounts for additives ratio), can cigarette filter at
During type, substitution plasticizer triacetyl glycerine is added in cigarette filter.It is the Red River Hong Yun group for addition cigarette
Cigarette " purple cloud " or " Camellia is soft ", are uniformly sprayed on filter tow by the 6-8wt% of filter tow weight and filter stick are made,
Then cigarette is made by conventional cigarette cigarette in the filter stick, carries out sensory evaluating smoking, and to be not added with the identical of the additive
Cigarette carries out sensory evaluating smoking as control sample.Smoking result shows: comparing with control, the compounds of this invention is added to cigarette filter
In mouth, reduce cigarette smoking dry sensation and irritant effects it is obvious, keep cigarette smoke softer, and can enrich cigarette flavor,
Increase the sweet sense of cigarette smoking, the effect for improving cigarette suction comfort is obvious.
Beneficial effects of the present invention:
1, additives of filter tip of the invention is in cigarette industry using easy to accomplish.In the filter stick formation process of production of cigarettes
In, triacetyl glycerine need to be added as cigarette filter and form plasticizer, additive amount is the 6-8wt% of filter stick tow weight.This
The additive of invention just considers the problem of industrial application is realized in the design phase, is targetedly mentioned using triacetyl glycerine
It takes, additive preparation；The principal component of gained additive is triacetyl glycerine (95wt% or more for accounting for additives ratio).This
Sample can substitute plasticizer triacetyl glycerine in cigarette filter forming process with additive of the present invention, in filter stick formation process
In by plasticizer add equipment be added in cigarette filter；Do not increase additional process, industrial application during production of cigarettes
It is very easy to realize.
2, the additives of filter tip invented extracts Yunnan Ji Yi fruit and snow mountain Radix Glycyrrhizae mixed extract for the first time, and based on it
In the cigarette of raw material addition.Organic acid rich in the Ji Yi fruit of Yunnan, with tempting sour taste；Its extract can increase
The sour of cigarette smoke neutralizes free nicotine, reduces cigarette smoking irritation；Contain the white radix scrophulariae of high sweet substance in snow mountain Radix Glycyrrhizae
Glucoside, sugariness is 600 times of sucrose, and sweet taste can be kept 1 hour or more, can effectively promote the sweet sense of cigarette smoking.Using
The advantages of two kinds of effect medicinal and edible plants are extracted by preferred proportion mixing, fully utilize two kinds of Yunnan Special plants.Moreover,
Yunnan Ji Yi fruit and snow mountain Radix Glycyrrhizae are Yunnan is widely distributed, biological yield is big, and raw material is easy to get, the sizable application in cigarette
It is easy to accomplish.
3, the additives of filter tip invented is except in addition to raw material based on Yunnan Ji Yi fruit and snow mountain Radix Glycyrrhizae, also using choosing
A variety of natural plant extracts and monomer perfume deploy additive.The fragrance for effectively enriching additive is rich, mentions
Improvement cigarette suction comfort effect is risen.Additives of filter tip formula of the invention is to be put forward for the first time.
4, also it is added in cigarette using kudzu root extract as antioxidant and antibacterial agent for the first time in the present invention, pueraria lobata mentions
Taking object is mainly pueraria isoflavone.The use of kudzu root extract can prevent additives of filter tip oxidation deterioration and putrid and deteriorated, hence it is evident that
Extend the shelf-life of additives of filter tip, and is obviously improved the stability after additives of filter tip adds in filter stick.In addition, different Huang
Ketone compounds, which are also important, improves sense of taste ingredient, effectively increases the moisture feeling of cigarette smoking, promotes suction comfort.
5, the drop that the present invention evaluates additives of filter tip of the present invention using up-regulation cell AQP5 expressing quantity for the first time is dry
Effect of promoting the production of body fluid increases the objectivity of additives of filter tip effect assessment with traditional artificial sense evaluation method formation supplement.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to embodiments to the present invention
It is described in further detail.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to
Limit the present invention.If not raw material employed in embodiment and equipment are refered in particular to, it is commercially available or commonly used in the art,
Method in embodiment is unless otherwise instructed the conventional method of this field.
Cigarette filter-tip additive agent of the present invention, be using Yunnan Ji Yi fruit and snow mountain Radix Glycyrrhizae as raw material, it is sweet through triacetic acid
Grease-glycerol-ethyl alcohol (mass ratio 80:10:10) extracts, and other functional components are being added in extracting solution, is deployed into cigarette filter
Mouth additive, the additive are added in cigarette filter in cigarette filter forming process by plasticizer, specifically:
A, the extraction of Yunnan Ji Yi fruit and snow mountain Radix Glycyrrhizae sample:
The root (3:2-4:1) in mass ratio of Yunnan Ji Yi fruit and snow mountain Radix Glycyrrhizae drying after vacuum drying mixes, and is crushed to
10-20 mesh.Be fitted into extractor, be added 5-8 times of sample quality glyceryl triacetate-glycerol-ethyl alcohol (mass ratio 80:10:
10) mixed solvent, refluxing extraction 2.0-3.0 hours lower in 80-100 DEG C of stirring, mixing speed is 80-120 revs/min.It extracts
Filter bag filters pressing is used after the completion, extracting solution and filter residue is obtained by filtration, and uses 1.8-2.2 times of material quality of ethanol washing filter residue again,
Filter residue and cleaning solution is obtained by filtration；Combined extract and cleaning solution boil off the ethyl alcohol in extracting solution in 90-100 DEG C of decompression, can obtain
The triacetyl glycerine of the mixed extract of southern Ji Yi fruit and snow mountain Radix Glycyrrhizae and the solution of glycerol.
B, the preparation of cigarette irritation additives of filter tip is reduced
The irritating additives of filter tip of reduction cigarette of the present invention, is made: Yunnan of the raw material of following mass percents
Ji Yi fruit and snow mountain Radix Glycyrrhizae mixed extract are 20-30wt%, Megastigmatrienone 0.1-0.15wt%, and Bronyl acetate is
0.2-0.3wt%, geranyl acetate are 0.2-0.3 problem %, Tween-80 0.5-1wt%, Fructus Perillae quintessence oil 0.2-
0.4wt%, chrysanthemum concrete 1.5-2wt%, essential oil of tobaccos 1.5-2wt%, kudzu root extract 0.2-0.5wt%；Its surplus
For triacetyl glycerine.Each raw material is uniformly mixed to obtained light yellow liquid, as required cigarette filter-tip additive agent.It is described
Yunnan Ji Yi fruit and snow mountain Radix Glycyrrhizae mixed extract are the three of Yunnan Ji Yi fruit and snow mountain Radix Glycyrrhizae mixed extract that step A obtains
The solution of acetoglyceride and glycerol.
C, the biological assessment of cigarette dry sensation irritation additives of filter tip is reduced
Using cell aquaporin 5 (AQP5) construct drop it is dry promote the production of body fluid model to drop additives of filter tip of the present invention into
Row evaluation.Salivary acinar cells are subjected to medical preconditioning first, it is made to simulate cell micro-environment when dry syndrome occurs,
Cell is stimulated using various concentration additives of filter tip again, the cells are fixed after stimulation, AQP5 penetrating, that FITC label is added
Antibody carries out dye marker, with high intension imaging system observation additives of filter tip treated cell AQP5 expressing quantity,
And compared with the cell controls handled without additives of filter tip.The result shows that: additives of filter tip of the present invention can raise cell
AQP5 expressing quantity illustrates that it has good effect of promoting the production of body fluid, and can promote the moisture feeling of cigarette smoking, reduces dry sensation and stimulation
Property.
D, the preparation of additives of filter tip and cigarette
The present invention is that cigarette filter forms most common plasticizer, and addition of the invention in view of triacetyl glycerine
Agent be using triacetyl glycerine as medium (95wt% or more that triacetyl glycerine accounts for additives ratio), can cigarette filter at
During type, substitution plasticizer triacetyl glycerine is added in cigarette filter.It is the Red River Hong Yun group for addition cigarette
Cigarette " purple cloud " or " Camellia is soft ", are uniformly sprayed on filter tow by the 6-8wt% of filter tow weight, filter are made
Then the filter stick is made cigarette by conventional cigarette cigarette, carries out sensory evaluating smoking, and to be not added with the phase of the additive by stick
Photosensitive smoke panel test is carried out as control with cigarette.Smoking result shows: comparing with control, the compounds of this invention is added to cigarette filter
In mouth, reduce cigarette smoking dry sensation and irritant effects it is obvious, keep cigarette smoke softer, and can enrich cigarette flavor,
Increase the sweet sense of cigarette smoking, the effect for improving cigarette suction comfort is obvious.
Embodiment 1: the system of the solution of the triacetyl glycerine and glycerol of Yunnan Ji Yi fruit and snow mountain Radix Glycyrrhizae mixed extract
It is standby
Snow mountain Radix Glycyrrhizae sample is collected in Lijiang, yunnan Yulong Xueshan, and Yunnan Ji Yi fruit sample is collected in Jinping, Yunnan, will be true
The root of Yunnan Ji Yi fruit and snow mountain Radix Glycyrrhizae drying after sky is dry is 3:2 mixing by mass percentage, is crushed to 10 mesh powders,
It is fitted into extractor, (mass ratio is that 80:10:10 mixing is molten to glyceryl triacetate-glycerol-ethyl alcohol of 5 times of powder sample quality of addition
Agent is stirred lower refluxing extraction 3.0 hours in 80 DEG C, and mixing speed is 80 revs/min.Filter bag filters pressing, filtering are used after the completion of extracting
Extracting solution out uses 2 times of powder sample quality of ethanol washing filter residue again.Combined extract and cleaning solution are boiled off in 100 DEG C of decompressions
Ethyl alcohol in extracting solution to get the triacetyl glycerine and glycerol of Yunnan Ji Yi fruit and snow mountain Radix Glycyrrhizae mixed extract solution.
Embodiment 2: the system of the solution of the triacetyl glycerine and glycerol of Yunnan Ji Yi fruit and snow mountain Radix Glycyrrhizae mixed extract
It is standby
Snow mountain Radix Glycyrrhizae sample is collected in the old Jun Mountain of Lijiang, yunnan, and Yunnan Ji Yi fruit sample is collected in Luliang, by vacuum
The root of Yunnan Ji Yi fruit and snow mountain Radix Glycyrrhizae drying after drying is 4:1 mixing by mass percentage, is crushed to the powder of 20 mesh.It is packed into
In extractor, 8 times of powder sample quality glyceryl triacetate-glycerol-ethyl alcohol (mass ratio 80:10:10) mixed solvent is added.
It is stirred in 100 DEG C lower refluxing extraction 2.5 hours, mixing speed is 100 revs/min.Filter bag filters pressing is used after the completion of extracting, and is filtered out
Extracting solution uses 1.8 times of powder sample quality of ethanol washing filter residue again.Combined extract and cleaning solution are boiled off in 90 DEG C of decompressions
Ethyl alcohol in extracting solution to get the triacetyl glycerine and glycerol of Yunnan Ji Yi fruit and snow mountain Radix Glycyrrhizae mixed extract solution.
Embodiment 3: the system of the solution of the triacetyl glycerine and glycerol of Yunnan Ji Yi fruit and snow mountain Radix Glycyrrhizae mixed extract
It is standby
Snow mountain Radix Glycyrrhizae sample is collected in Lijiang, yunnan and breathes out Ba Xueshan, and Yunnan Ji Yi fruit sample is collected in Shilin Park, Yunnan, China, will be true
The root of Yunnan Ji Yi fruit and snow mountain Radix Glycyrrhizae drying after sky is dry is 1:1 mixing by mass percentage, is crushed to 15 mesh powders.
It is fitted into extractor, 6 times of powder sample quality of glyceryl triacetate-glycerol-ethyl alcohol (mass ratio 80:10:10) mixing is added
Solvent.It is stirred in 90 DEG C lower refluxing extraction 3.0 hours, mixing speed is 120 revs/min.Filter bag filters pressing, mistake are used after the completion of extracting
Extracting solution is filtered out, uses 2.2 times of powder sample quality of ethanol washing filter residue again.Combined extract and cleaning solution subtract in 95 DEG C
Press the triacetyl glycerine and glycerol for boiling off the ethyl alcohol in extracting solution to get Yunnan Ji Yi fruit and snow mountain Radix Glycyrrhizae mixed extract
Solution.
Embodiment 4: the preparation of additives of filter tip
Reduction cigarette dry sensation of the present invention and irritating additives of filter tip, by the raw material system of following mass percents
At: the triacetyl glycerine of Yunnan Ji Yi fruit and snow mountain Radix Glycyrrhizae mixed extract in embodiment 1 and solution (the Yunnan Ji of glycerol
Yi fruit and snow mountain Radix Glycyrrhizae mixed extract are 20wt% in the additives of filter tip), Megastigmatrienone 0.1wt%, acetic acid borneol
Ester 0.2wt%, geranyl acetate 0.2wt%, Tween-80 1wt%, Fructus Perillae quintessence oil 0.4wt%, chrysanthemum concrete 2wt%, tobacco
Essential oil 2wt%, kudzu root extract 0.5wt%；Its surplus is triacetyl glycerine.By each raw material be uniformly mixed obtain it is light yellow
Liquid, as required cigarette filter-tip additive agent.The dry effect experiment cell aquaporin 5 that promotes the production of body fluid of the drop of additives of filter tip
(AQP5) experiment carries out, and salivary acinar cells are carried out medical preconditioning first, simulates it thin when dry syndrome occurs
Born of the same parents' microenvironment, then cell is stimulated using various concentration additives of filter tip, the cells are fixed after stimulation, penetrating, addition FITC
The AQP5 antibody of label carries out dye marker, with high intension imaging system observation additives of filter tip treated cell AQP5 egg
White expression quantity, and compared with the cell controls handled without additives of filter tip.The result shows that: additives of filter tip of the present invention can be with
Cell AQP5 expressing quantity is raised, up-regulation rate is more than 20%, illustrates that it has good effect of promoting the production of body fluid, to increase cigarette smoking
Moisture feeling, reduce dry sensation and irritation.
Embodiment 5: the preparation of additives of filter tip
The irritating additives of filter tip of reduction cigarette of the present invention, is made of the raw material of following mass percents: implementing
The triacetyl glycerine of Yunnan Ji Yi fruit and snow mountain Radix Glycyrrhizae mixed extract in example 2 and glycerol solution (Yunnan Ji Yi fruit and
Snow mountain Radix Glycyrrhizae mixed extract is 30wt% in the additives of filter tip), Megastigmatrienone 0.15wt%, Bronyl acetate is
0.3wt%, geranyl acetate 0.3wt%, Tween-80 0.5wt%, Fructus Perillae quintessence oil 0.2wt%, chrysanthemum concrete are
1.5wt%, essential oil of tobaccos 1.5wt%, kudzu root extract 0.2wt%；Its surplus is triacetyl glycerine.Each raw material is mixed
The light yellow liquid uniformly obtained, as required cigarette filter-tip additive agent.The dry effect experiment use of promoting the production of body fluid of the drop of additives of filter tip
Cell aquaporin 5 (AQP5) experiment carries out, and experimental method is the same as embodiment 4, the results showed that additives of filter tip of the present invention can be with
Cell AQP5 expressing quantity is raised, up-regulation rate is more than 25%.
Embodiment 6: the preparation of additives of filter tip
The irritating additives of filter tip of reduction cigarette of the present invention, is made of the raw material of following mass percents: implementing
The triacetyl glycerine of Yunnan Ji Yi fruit and snow mountain Radix Glycyrrhizae mixed extract in example 3 and glycerol solution (Yunnan Ji Yi fruit and
Snow mountain Radix Glycyrrhizae mixed extract is 25wt% in the additives of filter tip), Megastigmatrienone 0.1wt%, Bronyl acetate
0.2wt%, geranyl acetate 0.2wt%, Tween-80 0.5wt%, Fructus Perillae quintessence oil 0.3wt%, chrysanthemum concrete 1.5wt%, cigarette
Careless essential oil 1.5wt%, kudzu root extract 0.3wt%；Its surplus is triacetyl glycerine.By each raw material be uniformly mixed obtain it is shallow
Yellow liquid, as required cigarette filter-tip additive agent.The dry effect experiment cell aquaporin egg that promotes the production of body fluid of the drop of additives of filter tip
White 5 (AQP5) experiment carries out, and experimental method is the same as embodiment 4, the results showed that additives of filter tip of the present invention can raise cell AQP5
Expressing quantity, up-regulation rate are more than 20%.
Embodiment 7: application of the additives of filter tip in cigarette
The additives of filter tip of any preparation in Example 4-6 carries out the additive effect experiment of cigarette filter, test situation
It is as follows:
For the cigarette " purple cloud " that addition cigarette is the Red River Hong Yun group, by additive of the present invention by filter tow weight
7.5wt% is uniformly sprayed on filter tow, and filter stick is made, and volume then is made by conventional cigarette cigarette in the filter stick
Cigarette, carry out sensory evaluating smoking, and the identical cigarette to be not added with the compound as compare.Smoking result shows: comparing with control
Compared with the compounds of this invention is added in cigarette filter, reduces cigarette smoking dry sensation and irritant effects are obvious, make cigarette smoke
Sweet sense that is softer, and can enriching cigarette flavor, increase cigarette smoking, the effect for improving cigarette suction comfort are obvious.
Embodiment 8: application of the additives of filter tip in cigarette
The additives of filter tip of any preparation in Example 4-6 carries out the additive effect experiment of cigarette filter, test situation
It is as follows:
For the cigarette " Camellia is soft " that addition cigarette is the Red River Hong Yun group, additive of the present invention is pressed into filter tow weight
The 7.5wt% of amount is uniformly sprayed on filter tow, and filter stick is made, and then the filter stick is made up of conventional cigarette cigarette
Cigarette, carry out sensory evaluating smoking, and the identical cigarette to be not added with the compound as compare.Smoking result shows: and to photograph
Compare, the compounds of this invention is added in cigarette filter, reduces cigarette smoking dry sensation and irritant effects are obvious, make cigarette cigarette
Gas is softer, and the sweet sense that can be enriched cigarette flavor, increase cigarette smoking, the effect for improving cigarette suction comfort are bright
It is aobvious.
The basic principles, main features and advantages of the present invention have been shown and described above.The technology of the industry
Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and the above embodiments and description only describe this
The principle of invention, without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, these changes
Change and improvement all fall within the protetion scope of the claimed invention.The claimed scope of the invention by appended claims and its
Equivalent thereof.
Claims (5)
1. a kind of additives of filter tip, which is characterized in that including following mass component: Yunnan Ji Yi fruit and snow mountain Radix Glycyrrhizae mixing are extracted
Object is 20-30wt%, Megastigmatrienone 0.1-0.15wt%, Bronyl acetate 0.2-0.3wt%, and geranyl acetate is
0.2-0.3wt%, Tween-80 0.5-1wt%, Fructus Perillae quintessence oil 0.2-0.4wt%, chrysanthemum concrete 1.5-2wt%, tobacco
Essential oil is 1.5-2wt%, kudzu root extract 0.2-0.5wt%；Its surplus is triacetyl glycerine.
2. additives of filter tip according to claim 1, which is characterized in that the Yunnan Ji Yi fruit and snow mountain Radix Glycyrrhizae mixing mention
Take the solution for the triacetyl glycerine and glycerol that object is Yunnan Ji Yi fruit and snow mountain Radix Glycyrrhizae mixed extract.
3. additives of filter tip according to claim 2, which is characterized in that the Yunnan Ji Yi fruit and snow mountain Radix Glycyrrhizae mixing mention
The preparation step of the triacetyl glycerine and glycerite that take object includes:
It (1) is by mass percentage 3:2-4:1 co-grinding to 10-20 mesh powder sample by Yunnan Ji Yi fruit and snow mountain Radix Glycyrrhizae
5-8 times of powder sample quality of the Extraction solvent is added in product, and extraction 2.0-3.0 hours is stirred at reflux at 80-100 DEG C；Institute
Stating Extraction solvent is the glyceryl triacetate that mass ratio is 80:10:10: glycerol: the mixed solvent of ethyl alcohol；
(2) product after filtration step (1) refluxing extraction obtains extracting solution and filter residue, again with the powder sample quality 1.8-
Cleaning solution is obtained by filtration in 2.2 times of ethanol washing filter residue, merges the extracting solution and the cleaning solution, steams in 90-100 DEG C of decompression
Ethyl alcohol is gone to obtain the triacetyl glycerine and glycerite of the Yunnan Ji Yi fruit and snow mountain Radix Glycyrrhizae mixed extract.
4. additives of filter tip according to claim 1 is for reducing cigarette smoking dry sensation and irritating purposes.
5. purposes according to claim 4, which is characterized in that the reduction cigarette smoking dry sensation and irritating purposes
Evaluation method reduction cigarette smoking dry sensation and the stimulation of the additives of filter tip are evaluated using cell AQP5 expressing quantity
The effect of property.
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