CN109111464A - 一种具有细胞坏死抑制活性的杂环化合物 - Google Patents
一种具有细胞坏死抑制活性的杂环化合物 Download PDFInfo
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- CN109111464A CN109111464A CN201810575869.7A CN201810575869A CN109111464A CN 109111464 A CN109111464 A CN 109111464A CN 201810575869 A CN201810575869 A CN 201810575869A CN 109111464 A CN109111464 A CN 109111464A
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- synthesis
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- radical
- alkyl
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- Chemical & Material Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Description
Claims (13)
Priority Applications (6)
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KR1020197036806A KR102367257B1 (ko) | 2017-06-23 | 2018-06-23 | 괴사 억제제로서 헤테로아릴 화합물, 이의 조성물 및 이의 이용 방법 |
JP2019569828A JP6950006B2 (ja) | 2017-06-23 | 2018-06-23 | ネクローシス阻害剤であるヘテロアリール化合物、それを用いる組成物及び方法 |
PCT/US2018/039180 WO2018237370A1 (en) | 2017-06-23 | 2018-06-23 | HETEROARYL COMPOUNDS AS INHIBITORS OF THE NECROSIS, COMPOSITION AND METHOD OF USE THEREOF |
EP18819803.0A EP3642193B1 (en) | 2017-06-23 | 2018-06-23 | Heteroaryl compounds as inhibitors of necrosis and related composition |
US16/625,703 US11339177B2 (en) | 2017-06-23 | 2018-06-23 | Heteroaryl compounds as inhibitors of necrosis, composition and method using the same |
ES18819803T ES2916549T3 (es) | 2017-06-23 | 2018-06-23 | Compuestos heteroarilo como inhibidores de necrosis y composición relacionada |
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JP (1) | JP6950006B2 (zh) |
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CN (1) | CN109111464B (zh) |
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CN114127067A (zh) * | 2019-07-17 | 2022-03-01 | 百济神州有限公司 | 作为hpk1抑制剂的三环化合物及其用途 |
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CN115894489A (zh) * | 2021-09-22 | 2023-04-04 | 中国药科大学 | 一种受体相互作用蛋白激酶1的抑制剂及其制备方法、应用 |
Citations (6)
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WO2010100144A1 (en) * | 2009-03-04 | 2010-09-10 | Merck Serono S.A. | Fused bicyclic compounds as inhibitors for pi3 kinase |
CN102015726A (zh) * | 2008-03-31 | 2011-04-13 | C&C新药研究所 | 杂环衍生物 |
US20110172217A1 (en) * | 2008-09-05 | 2011-07-14 | Shionogi & Co., Ltd. | Ring-fused morpholine derivative having pi3k-inhibiting activity |
US20110178070A1 (en) * | 2008-06-24 | 2011-07-21 | Takeda Pharmaceutical Company Limited | PI3K/mTOR INHIBITORS |
US20160235758A1 (en) * | 2011-02-23 | 2016-08-18 | Intellikine Llc | Combination of mtor inhibitors and pi3-kinase inhibitors, and uses thereof |
US20160256458A1 (en) * | 2013-11-18 | 2016-09-08 | Forma Therapeutics, Inc. | Benzopiperazine compositions as bet bromodomain inhibitors |
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US9422281B2 (en) * | 2013-11-18 | 2016-08-23 | Forma Therapeutics, Inc. | Benzopiperazine compositions as BET bromodomain inhibitors |
CN107641118B (zh) | 2016-07-22 | 2020-11-06 | 爱科诺生物医药股份有限公司 | 具有细胞坏死抑制活性的化合物及其组合物和应用 |
WO2018017435A1 (en) * | 2016-07-22 | 2018-01-25 | Accro Bioscience Inc. | Heteroaryl compounds as inhibitors of necrosis, composition and application thereof |
CA3054161A1 (en) * | 2017-03-30 | 2018-10-04 | F. Hoffmann-La Roche Ag | Isoquinolines as inhibitors of hpk1 |
-
2018
- 2018-06-06 CN CN201810575869.7A patent/CN109111464B/zh active Active
- 2018-06-23 KR KR1020197036806A patent/KR102367257B1/ko active IP Right Grant
- 2018-06-23 JP JP2019569828A patent/JP6950006B2/ja active Active
- 2018-06-23 ES ES18819803T patent/ES2916549T3/es active Active
- 2018-06-23 EP EP18819803.0A patent/EP3642193B1/en active Active
- 2018-06-23 US US16/625,703 patent/US11339177B2/en active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102015726A (zh) * | 2008-03-31 | 2011-04-13 | C&C新药研究所 | 杂环衍生物 |
US20110178070A1 (en) * | 2008-06-24 | 2011-07-21 | Takeda Pharmaceutical Company Limited | PI3K/mTOR INHIBITORS |
US20110172217A1 (en) * | 2008-09-05 | 2011-07-14 | Shionogi & Co., Ltd. | Ring-fused morpholine derivative having pi3k-inhibiting activity |
WO2010100144A1 (en) * | 2009-03-04 | 2010-09-10 | Merck Serono S.A. | Fused bicyclic compounds as inhibitors for pi3 kinase |
US20160235758A1 (en) * | 2011-02-23 | 2016-08-18 | Intellikine Llc | Combination of mtor inhibitors and pi3-kinase inhibitors, and uses thereof |
US20160256458A1 (en) * | 2013-11-18 | 2016-09-08 | Forma Therapeutics, Inc. | Benzopiperazine compositions as bet bromodomain inhibitors |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN114127067A (zh) * | 2019-07-17 | 2022-03-01 | 百济神州有限公司 | 作为hpk1抑制剂的三环化合物及其用途 |
CN114127067B (zh) * | 2019-07-17 | 2024-08-23 | 百济神州有限公司 | 作为hpk1抑制剂的三环化合物及其用途 |
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KR20200017411A (ko) | 2020-02-18 |
ES2916549T3 (es) | 2022-07-01 |
US20210155635A1 (en) | 2021-05-27 |
JP6950006B2 (ja) | 2021-10-13 |
CN109111464B (zh) | 2021-02-26 |
EP3642193B1 (en) | 2022-04-27 |
KR102367257B1 (ko) | 2022-02-24 |
EP3642193A4 (en) | 2021-03-10 |
US11339177B2 (en) | 2022-05-24 |
EP3642193A1 (en) | 2020-04-29 |
JP2020525417A (ja) | 2020-08-27 |
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