CN1091009A - Marine biological health protection product " Jinhaixing " oral liquor - Google Patents
Marine biological health protection product " Jinhaixing " oral liquor Download PDFInfo
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- CN1091009A CN1091009A CN93116535A CN93116535A CN1091009A CN 1091009 A CN1091009 A CN 1091009A CN 93116535 A CN93116535 A CN 93116535A CN 93116535 A CN93116535 A CN 93116535A CN 1091009 A CN1091009 A CN 1091009A
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- asterias amurensis
- amurensis lutken
- lutken
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Abstract
The present invention is for deriving from halobiontic health food or medicine preparation.It is that extract with one or more Asterias amurensis Lutkenes in the Echinodermata Asteroidea biology is prepared into various oral formulations, comprises tablet, unguentum, nutrition oral administration, capsule.This product contains rich in amino acid, vitamin, various trace elements, natural taurine, glycogen, acid mucopolysaccharide and active substance; so have the double effects of health care and nourishing the human Body, weak and sickly immunologic hypofunction patient had good raise immunity effect.
Description
The invention belongs to and derive from halobiontic health food or medicine preparation.
Wide coastal of China has abundant marine resources, and Asterias amurensis Lutken is again to be distributed in China's southeastern coast one band, is grown in abyssal marine product.Always among the people with Asterias amurensis Lutken as a kind of health food, it is edible to boil lean meat with the dry product of Asterias amurensis Lutken, as control thyromegaly, chronic pharyngitis, tonsillitis etc.In " Chinese medicinal marine organisms " book of＜China People's Liberation Army Navy logistics department's Ministry of Public Health, Shanghai Institute of Pharmaceutical Industry＞write, reported Asterias amurensis in the Asteroidea biology; Craspidaster hesperus (mulleret Troschel).; Knight Zhang Haixing; True five jiaos of Asterias amurensis Lutkenes; Flos Rosae Multiflorae Asterias amurensis Lutken tool suppressing the hyperactive liver and easing the stomach, relieving gastric hyperacidity to alleviate stomachache, heat-clearing and toxic substances removing; Relieving convulsion function can be used for treating gastric and duodenal ulcers, the stomachache acid regurgitation; Thyromegaly; Diarrhoea; Otitis media etc.Having put down in writing Potiria pectinifera (Mukller et Tro Sehel) (belonging to Asteroidea) in the Compendium of Material Medica has " the overcast and rainy damage pain of sending out, liquor clothes, the effect that extracting juice is promptly separated.Also go into drugs for nourishing yin.Among the peoplely also come wind-damp dispelling with Potiria pectinifera (Mukller et Tro Sehel).With the direct decocting in water of Potiria pectinifera (Mukller et Tro Sehel), clothes back diaphoresis can be treated lumbago and skelalgia.Forging Potiria pectinifera (Mukller et Tro Sehel) grinds into powder to take after mixing it with water and can treat for stomachache etc.As seen, Asterias amurensis Lutken is a kind of marine resources of worth development and use.Yet foundation and the not enough science of method that folklore uses Asterias amurensis Lutken to cure the disease are taken also inconvenience, and reported in literature are arranged, and some Asterias amurensis Lutken is deleterious, contains Toxic matter in its tissue, so among the people undressed Asterias amurensis Lutken is eaten is unscientific.
The objective of the invention is to utilize living marine resources-Asterias amurensis Lutken, preparing a kind ofly has health-care effect and avirulence to health, safe and reliable, meets the health food of food hygienic standard, and the production technology simple possible, can be fit to industrial mass manufacture.
The present invention is achieved in that the various Asterias amurensis Lutkenes with each subordinate of section of Echinodermata Asteroidea (Asteroidea) in the marine organisms are raw material, is confirmed to be China's southeastern coast several to abound with that can to do medicinal Asterias amurensis Lutken be best especially.As Craspidaster hesperus (mulleret Troschel). (Craspidastar.hasperus), knight Zhang Haixing (Stellastar equestris), the positive Asterias amurensis Lutken of tool wrist (Nediaster brachiatus), Asterias amurensis (Asterias amurensin), Potiria pectinifera (Mukller et Tro Sehel) (Asterina peclinifera), true five jiaos of Asterias amurensis Lutkenes (Anthenea pentagonula), Flos Rosae Multiflorae Asterias amurensis Lutken (Rosaster symbolieus) is got the mixing of wherein a kind of Asterias amurensis Lutken or several Asterias amurensis Lutken and all can make raw material.Asterias amurensis Lutken that these are fresh or Asterias amurensis Lutken dry product, gill, clean with the clear water rinsing, handle the back stripping and slicing place extract that pot extracts with solution as: water or ethanol liquid or dilute alkaline soln, get its extract and be equipped with adjuvant that food and medicine allow or/and additive food prepared therefrom or pharmaceutically acceptable various oral agents.In order to destroy the toxic component-starfish saponin in the Asterias amurensis Lutken and to extract effective ingredient such as more mucopolysaccharide, it is considered herein that and extract best with dilute alkaline soln, the hot lifting manipulation of at first available normal pressure is about to Asterias amurensis Lutken and places and extract the solution branch second extraction that adds dilute alkali behind the pot, each heated and boiled is more than one hour, merge secondary filtrate and transfer to the dilute alkaline soln extracting solution that the PH6.5-7.3 after-filtration is Asterias amurensis Lutken with acid, this extracting solution further can be condensed into and carry out drying, pulverizing after thick, for the dry substance of Asterias amurensis Lutken extracting solution or claim golden Asterias amurensis Lutken dry powder.Also can adopt the method for dilute alkaline soln pressurised extraction, promptly cold, filtration is put in the heating pressurization after half an hour under 0.1-0.2MPa, and filtrate transfers to PH6.0-7.5 with acid, later on the hot lifting manipulation of normal pressure.
The dilute alkaline soln that extracts usefulness can be with the sodium hydroxide solution of 0.1mol/L-2mol/L concentration, also available hydrogen potassium oxide, sodium carbonate, sodium bicarbonate solution.Best in order to reduce cost with rare sodium hydroxide solution.For edible, its extracting solution can be with mineral acid that food or medicine allowed or organic acid example hydrochloric acid, acetic acid, and Fructus Citri Limoniae is waited and regulates pH value and make pH value reach 6.0-7.5.The peroral dosage form that can make with above-mentioned starfish extract has unguentum, electuary (granule), tablet, capsule, mixture (comprising nutrition oral administration) etc.
(1) will carry the extractum that thing liquid further is condensed into suitable density, be electuary after adding an amount of auxiliary materials and mixing granulation or being pressed into the piece drying;
(2) add adjuvant after extracting solution is condensed into cream, granulation is sieved, and tabletting is the extractum sheet, and further sugar coating is a coated tablet.
(3) extracting solution is added in the liquid syrup of appropriateness and add an amount of antiseptic and make syrup.
(4) extracting solution is condensed into adds adjuvant behind the extractum and become the back filling of sieving of uniform powder or granule in Capsules, to make capsule.
(5) extracting solution is added refined honey or sugar and make viscid soft extract.
(6) concentrated solution adds correctives, antiseptic, water to make liquid preparation for oral administration is mixture, is distributed into single dose and then is nutrition oral administration.
The present invention is ideal dosage form to make unguentum, nutrition oral administration, tablet, capsule.
Unguentum: dry substance 0.4-2%, the natural sweetener 50-90%, water 8-48% and an amount of antiseptic that contain the Asterias amurensis Lutken extracting solution in 100 milliliters of cream.
Nutrition oral administration: dry substance 0.4-2%, the natural sweetener 15-25%, Fructus Jujubae aqueous extract 15-25%, water 48-65% and an amount of antiseptic that contain the Asterias amurensis Lutken extracting solution in 100 milliliters.
Tablet: the dry substance 10-40%, the pharmaceutic adjuvant 60-90% that contain the Asterias amurensis Lutken extracting solution.
Capsule: the dry substance 10-40%, the pharmaceutic adjuvant 60-90% that contain the Asterias amurensis Lutken extracting solution.
Asterias amurensis Lutken oral agents provided by the invention contains rich in protein after testing, and 17 seed amino acids are arranged; multivitamin; trace element zinc, ferrum, copper, selenium, iodine enrich natural taurine, glycogen, acid mucopolysaccharide, active substance in addition, so have health care and nourishing the human Body dual-use function.Prove that through pharmacological evaluation Asterias amurensis Lutken extracting solution provided by the invention alleviates causing mouse spleen weight with the bold and vigorous mud pine of hydrogenation, the caused by cyclophosphamide murine interleukin reduces and weight loss all has obvious antagonism to using; Can suppress Mouse Liver inner lipid peroxidization, can prolong the life span of mice when the normobaric hypoxia state significantly, normal mouse immune organ weight, body weight are not had obvious influence; Normal mouse anti low temperature ability there is not influence.Oral this product LD＞1200mg/Kg, dosis tolerata＞50g/Kg.Carry out micronucleus test proof this product with Schnnd ' s method and do not cause that the PCEMNR micronuclear rates raises, carry out spermatic aberration test proof this product by " foodsafety assessment process " method and do not cause that the animal subject rate of teratosperm raises; Adopt the flat board method of mixing to carry out Ames ' test, prove that this product is negative under set dosage.Prove by serial experiment: health product provided by the invention are to belong to nontoxicly, and mice somatic cell and sexual cell and cell in vitro are not had mutagenic action, are an immunostimulant and keep fit the health product of strong body.After particularly tumour patient radiotherapy, the chemotherapy, leukocyte obviously descends, and takes these health product leukocyte is obviously raise, and plays good auxiliary treatment effect.Weak and sickly immunologic hypofunction patient is had good raise immunity effect, is pure natural tonic nutriment.
Embodiment one, golden Asterias amurensis Lutken cream
Get the dried Asterias amurensis Lutken of 10 grams, the positive Asterias amurensis Lutken of tool wrist, knight Zhang Haixing, Asterias amurensis are arranged through discriminating.Rinsing clean back chopping is put and is added 1mol/L sodium hydroxide solution 40L in the reaction pot, heated and boiled two hours, cold back leaching filtrate, filtering residue adds the sodium hydroxide solution 20L of 2mol/L, heated and boiled 1 hour is filtered, and merges secondary filtrate, transferring to PH with the 5mol/L hydrochloric acid solution is 6.8, filter, the filtrate evaporation and concentration is Asterias amurensis Lutken and extracts concentrated solution to 10L, this product is that the distinctive delicate flavour of brown viscous liquid tool marine organisms is very easily water-soluble, contains dry substance 16.1%(W/V).
Get concentrated solution: 1.1Kg, with maltose 23.5Kg, liquid glucose 23.5Kg, distilled water 7Kg, puddle is heated to 80-85 ℃ in pot, adds potassium sorbate 20 grams, boils 10 minutes, take advantage of packing behind the heat filtering, embedding, sterilization, decals packing, every bottle of 100ml contains Asterias amurensis Lutken and extracts dry substance 0.4%(W/V).
Embodiment two, golden Asterias amurensis Lutken cream
Get the Asterias amurensis Lutken of example one and extract concentrated solution 1.1Kg, add liquid glucose 4.7Kg, maltose 4.7Kg, distilled water 1.4Kg is heated with stirring to 80-85 ℃ in pot, add potassium sorbate 4 grams, boil and took advantage of packing behind the heat filtering in 10 minutes, embedding, sterilization, decals packing, every bottle of 100ml contains Asterias amurensis Lutken and extracts dry substance 1.8%.
Embodiment three, golden Asterias amurensis Lutken nutritional solution
Get the dried Asterias amurensis Lutken of 10Kg, Potiria pectinifera (Mukller et Tro Sehel) is arranged, the positive Asterias amurensis Lutken of tool wrist through discriminating, discard internal organs rinsing clean back chopping and put the sodium hydroxide solution that adds 40Kg0.5mol/L in the reaction pot, heated and boiled makes pressure reach 0.10MPa, stops heating after half an hour, puts the sodium hydroxide solution 20Kg that cold filtration adds 1mol/L, heated and boiled 1 hour, filter, merge secondary filtrate, transferring PH with the hydrochloric acid solution of 5mol/L is 7.3 filtrations, filtrate decompression is concentrated into 20L, contains dry substance 8.2%(W/V).
Get this extracting solution 2.2Kg with maltose 6 grams, Mel 2 grams, Fructus Jujubae aqueous extract 8Kg, water 20Kg, stirring boil added in 10 minutes potassium sorbate a little, filter the back packing, embedding, sterilization, packing, every bottle has 10ml, 100ml, three kinds of specifications of 150ml contain Asterias amurensis Lutken and extract dry substance 0.45%(W/V).
Embodiment four, golden Asterias amurensis Lutken nutritional solution
Get the extracting solution 2.2Kg of example three, with maltose 3Kg, Mel 1Kg, Fructus Jujubae aqueous extract 4Kg, water 10Kg stirs and boiled 10 minutes, and it is an amount of to add potassium sorbate, filters the back packing, and embedding, sterilization, packing contain Asterias amurensis Lutken and extract dry substance 0.89%.
Embodiment five, golden Asterias amurensis Lutken nutrition sheet
Get the dried Asterias amurensis Lutken of 10Kg, Craspidaster hesperus (mulleret Troschel). is arranged, true five jiaos of Asterias amurensis Lutkenes, Flos Rosae Multiflorae Asterias amurensis Lutken, Potiria pectinifera (Mukller et Tro Sehel) through discriminating.Handle the sodium carbonate solution 40L that adds 12%W/V in the rearmounted reaction pot with example one, heating is controlled at 0.1MPa and heats half an hour down, filter, filtering residue adds 12% sodium carbonate liquor 20L heating pressurization 0.5 hour again, filter, merge secondary filtrate, transfer PH to reach 7 with citric acid, evaporation and concentration contains dry substance 45%(W/V to 4L).
Get extracting solution 1.15Kg with dried starch 3Kg Icing Sugar 0.5Kg, granulate behind the dextrin 0.5Kg mixing, tabletting behind the dry pulverizing, every heavily has 0.15 gram, 0.2 gram, three kinds of specifications of 0.25 gram, contain Asterias amurensis Lutken and extract dry substance 10%(W/V), can continue sugar coating again and make coated tablet.
Embodiment six, golden Asterias amurensis Lutken capsule
The Asterias amurensis Lutken extracting solution 1.15Kg that gets example five granulates after with dried starch 2Kg mix homogeneously, and drying is gone into capsule after sieving, polishing back packing, and every heavy 250mg, 300mg, 350mg contain Asterias amurensis Lutken and extract dry substance 18.36%.
Embodiment seven, golden Asterias amurensis Lutken capsule
The Asterias amurensis Lutken extracting solution of getting example five is put 105 ℃ in baking oven and was cured five hours, takes out pulverizing and sieves, and gets dry powder 1Kg, after with going into capsule behind the dried starch 1.5Kg mixing, every weight 0.25g, 0.3g, 0.35g contain Asterias amurensis Lutken and extract smart powder 40%.
Claims (7)
1, a kind of marine organism health care product is characterized in that containing the biological extract 0.4-40% (in dry substance) of Echinodermata Asterias amurensis Lutken steel (Asteroidea) and are equipped with food or the pharmaceutically acceptable oral agents that adjuvant that food and medicine allowed or/or additive are made.
2, health product according to claim 1, it is characterized in that containing the Craspidaster hesperus (mulleret Troschel). (Craspidastar.hasperus) in the Asteroidea biology, knight Zhang Haixing (Stellastar equsetris), the positive Asterias amurensis Lutken of tool wrist (Wddiaster brachiatus), Asterias amurensis (Asterias amurensis), Potiria pectinifera (Mukller et Tro Sehel) (Asterina peclinifera), true five jiaos of Asterias amurensis Lutkenes (Anthenea pentagonula), Flos Rosae Multiflorae Asterias amurensis Lutken (Rosaster symbolicus), the wherein oral agents made of the blended extract of one or more Asterias amurensis Lutkenes.
3, health product according to claim 1 and 2 is characterized in that containing the oral agents that the extract of the biological dilute alkaline soln of Asteroidea is made.
4, health product according to claim 1 and 2 is characterized in that oral agents is a unguentum, contain dry substance 0.4-2%, natural sweetener 50-90%, water 8-48% and an amount of antiseptic of Asterias amurensis Lutken extracting solution.
5, health product according to claim 3 is characterized in that oral agents is a nutrition oral administration, contain dry substance 0.4-2%, natural sweetener 15-25%, Fructus Jujubae aqueous extract 15-25%, water 48-65% and an amount of antiseptic of Asterias amurensis Lutken extracting solution.
6, health product according to claim 3 is characterized in that oral agents is the nutrition sheet, and every weight 0.15-0.25 restrains, and contains dry substance 10-40%, the pharmaceutic adjuvant 60-90% of Asterias amurensis Lutken extracting solution.
7, health product according to claim 3 is characterized in that oral agents is a capsule, and every heavy 0.25-0.35 of capsule restrains, and contains dry substance 10-40%, the pharmaceutic adjuvant 60-90% of Asterias amurensis Lutken extracting solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93116535A CN1091009A (en) | 1993-08-23 | 1993-08-23 | Marine biological health protection product " Jinhaixing " oral liquor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93116535A CN1091009A (en) | 1993-08-23 | 1993-08-23 | Marine biological health protection product " Jinhaixing " oral liquor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1091009A true CN1091009A (en) | 1994-08-24 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93116535A Pending CN1091009A (en) | 1993-08-23 | 1993-08-23 | Marine biological health protection product " Jinhaixing " oral liquor |
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| Country | Link |
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| CN (1) | CN1091009A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1093386C (en) * | 1997-05-10 | 2002-10-30 | 烟台市水产技术推广中心 | Sea star product |
| CN101904508A (en) * | 2010-07-14 | 2010-12-08 | 大连天伦水产有限公司 | Starfish oral solution and preparation method thereof |
| CN102145015A (en) * | 2011-03-28 | 2011-08-10 | 山东大学威海分校 | Asterias amurensis amylase extractive and applications thereof |
| CN102973606A (en) * | 2012-12-31 | 2013-03-20 | 中国科学院南海海洋研究所 | Sea moth extract as well as preparation method thereof and application thereof |
| CN106923240A (en) * | 2017-03-02 | 2017-07-07 | 烟台沃特福得水产科技有限公司 | A kind of preparation method of the oral stoste of petrel and petrel lozenge |
-
1993
- 1993-08-23 CN CN93116535A patent/CN1091009A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1093386C (en) * | 1997-05-10 | 2002-10-30 | 烟台市水产技术推广中心 | Sea star product |
| CN101904508A (en) * | 2010-07-14 | 2010-12-08 | 大连天伦水产有限公司 | Starfish oral solution and preparation method thereof |
| CN102145015A (en) * | 2011-03-28 | 2011-08-10 | 山东大学威海分校 | Asterias amurensis amylase extractive and applications thereof |
| CN102973606A (en) * | 2012-12-31 | 2013-03-20 | 中国科学院南海海洋研究所 | Sea moth extract as well as preparation method thereof and application thereof |
| CN106923240A (en) * | 2017-03-02 | 2017-07-07 | 烟台沃特福得水产科技有限公司 | A kind of preparation method of the oral stoste of petrel and petrel lozenge |
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