CN109030810A - A kind of continuous preparation method of antibody (or antigen) coating microballoon - Google Patents
A kind of continuous preparation method of antibody (or antigen) coating microballoon Download PDFInfo
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- CN109030810A CN109030810A CN201810416852.7A CN201810416852A CN109030810A CN 109030810 A CN109030810 A CN 109030810A CN 201810416852 A CN201810416852 A CN 201810416852A CN 109030810 A CN109030810 A CN 109030810A
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- tank
- microballoon
- antibody
- tank body
- antigen
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
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- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
The invention discloses a kind of continuous preparation methods of antibody (or antigen) coating microballoon, described specific preparation process is as follows: step 1: preparation microballoon, antibody or antigenic solution, condensing agent and buffer first, step 2: microballoon and the condensing agent in condensing agent tank in microballoon tank being injected in the first tank body by first pressure pump and pipeline and mixed, and antibody or antibody in antigenic solution tank or antigenic solution are with the buffer in buffering flow container by being mixed in first pressure pump and pipeline the second tank body of injection.The present invention passes through in liquid mixed process, hot-air is passed through by air inlet pipe, not only mix liquid more uniform, and it can be heated to mixing liquid, the speed and efficiency for accelerating antibody or antigen coat microballoon keep microballoon coating more preferable, and procedure of processing is simple, it can constantly serialization prepare, can be suitable for producing in enormous quantities.
Description
Technical field
The present invention relates to antibody (or antigens) to be coated with microballoon field, in particular to a kind of antibody (or antigen) coating microballoon
Continuous preparation method.
Background technique
Antibody or antigen coat (absorption) can be divided into two classes to the process on microballoon.One kind being called physical absorption
Method, basic process are to mix antibody or antigen in suitable buffer system with coated microballoon is wanted, using antibody or
The interaction force of the macromoleculars such as antigen and microsphere surface generates absorption, so that macromolecular is fixed on microsphere surface, realizes micro-
The coated process of ball.Another method is called chemiadsorption, and basic process is some active group (examples using microsphere surface
Such as carboxyl, amino, hydroxyl, sulfydryl) to the corresponding group (amino, carboxyl, sulfydryl etc.) in the macromoleculars such as antibody or antigen
Reaction forms chemical bond under certain conditions, so that macromolecular is fixed on microsphere surface, realizes antibody or antigen micro-
The absorption of ball surface.Both methods is inherently the reaction of solid phase (microballoon) and water phase (solution of antibody or antigen).
It is small-scale in laboratory, it is often used vortex mixed.In fairly large production, generally using magnetic agitation, stirring paddle stirring, machine
The modes such as tool stirring carry out the mixing of two-phase.In this operating condition, the mixing of substantially uniformity is not easy reality very much between two-phase
Existing, the microenvironment around each microballoon might have very big difference, this directly results in the difference between the microballoon after being coated with
Greatly, the problems such as product differentiation between each batch in coating reaction production is greatly, the utilization rate of antibody (or antigen) is not high.And
And before microballoon is mixed with antibody (or antigen), microballoon be intended to disperse with antibody (or antigen) it is highly uniform, otherwise microballoon mark
It is easy to happen agglomeration after antibody, causes microballoon coating uneven.
Therefore, inventing a kind of continuous preparation method of antibody (or antigen) coating microballoon, have very much must to solve the above problems
It wants.
Summary of the invention
The purpose of the present invention is to provide a kind of continuous preparation methods of antibody (or antigen) coating microballoon, by liquid
In body mixed process, hot-air is passed through by air inlet pipe, not only mixes liquid more uniform, but also mixing liquid can be given
The speed and efficiency of antibody or antigen coat microballoon are accelerated in heating, keep microballoon coating more preferable, and procedure of processing is simple, can
Continuous serialization preparation can be suitable for producing in enormous quantities, to solve the problems mentioned in the above background technology.
To achieve the above object, the invention provides the following technical scheme: a kind of antibody (or antigen) is coated with the continuous of microballoon
Change preparation method, described specific preparation process is as follows:
Step 1: preparation microballoon, antibody or antigenic solution, condensing agent and buffer first；
Step 2: the condensing agent in the microballoon and condensing agent tank in microballoon tank is pumped by first pressure and pipeline injects the
It is mixed in one tank body, antibody or antibody in antigenic solution tank or the buffer in antigenic solution and buffering flow container pass through the
One pressure pump and pipeline, which inject in the second tank body, to be mixed；
Step 3: it is equipped with the first air inlet pipe in the first tank body and the second tank body, is worked by blower, gas is through inlet manifold
It is blown to heated layer heating inside gas-distributing pipe, hot gas is then passed through into the first tank body and the second tank body by the first air inlet pipe,
Generating bubble is uniformly mixed liquid；
Step 4: and then a left side will be passed through respectively with the intracorporal mixing liquid of the second tank in the first tank body by second pressure pump
In multiple inclined isocons of the fan-shaped distribution of the general pipeline filling main bottom connection of right setting, the translateral shunting of liquid
After pipe shunts respectively, it is in charge of interior mixed into summarizing for middle part；
Step 5: the pressure for the liquid that mixed liquid is constantly entered in step 3 and it is aggregated be in charge of upwards it is defeated
Send, in transmission process, summarize be in charge of it is internal hot gas is passed through by the second air inlet pipe, generate bubble and simultaneously heat mixing liquid, quickening
The association reaction of microballoon and antibody or antigenic solution, and it is uniformly mixed mitigation liquid, make peripheral ring locating for each microballoon
Border is identical；
Step 6: mixing liquid be delivered to summarize be in charge of top filtering tank in when, flow to the inclination of two sides in filtering tank
Impurity screening on the filter membrane of setting, impurity are discharged through the sewage pipe of filtering tank side, and obtained coating microballoon is arranged through drainage conduit
Out.
Preferably, first top of the tank is connected with microballoon tank and condensing agent tank by pipeline, and the pipeline is equipped with
Pressure pump, second top of the tank are connected with by pipeline equipped with antibody or antigenic solution tank and buffer tank, and described first
Tank body and the second tank interior are equipped with the first air inlet pipe, and general pipeline is equipped on the inside of first tank body and the second tank body, described total
Pipe is pumped equipped with second pressure, and total tube end is fixed with isocon, and the shunting bottom of the tube, which is equipped with to summarize, to be in charge of, described
Summarize and be in charge of top equipped with filtering tank, the filtering tank inside is equipped with filter membrane.
Preferably, it is equipped with gas-distributing pipe at the top of first air inlet pipe and the second air inlet pipe, the gas-distributing pipe inner wall, which is equipped with, to be added
Thermosphere, the heating layer include heater strip, and temperature sensor is equipped with inside the gas-distributing pipe, is equipped with air inlet at the top of the gas-distributing pipe
General pipeline, the inlet manifold are equipped with blower.
Preferably, the isocon is set as multiple and fan-shaped distribution, and the isocon is set as skewed, the remittance
Always it is in charge of and the isocon one-to-one correspondence and integrated molding on the inside of the first tank body and the second tank body.
Preferably, filtering tank corresponding with the filter membrane side is equipped with sewage pipe, and the filtering pot bottom is equipped with discharge
Pipe, the filter membrane is set as multilayer and section is disposed as annular.
Technical effect and advantage of the invention:
1, by being passed through hot-air by air inlet pipe in liquid mixed process, not only mix liquid more uniform,
And can be heated to mixing liquid, accelerate the speed and efficiency of antibody or antigen coat microballoon, keeps microballoon coating more preferable, and
Procedure of processing is simple, can constantly serialization prepare, high in machining efficiency, can be suitable for producing in enormous quantities；
2, it is uniformly dispersed before being on the other hand passed through hot-air microballoon and antibody or antigen capable of being made to mix, facilitates the later period mixed
The case where conjunction, uniformly, effect is more preferable, and after antibody or antigen coat microballoon for microballoon coating, and microballoon is avoided to reunite；
3, the apparatus structure for preparing antibody or antigen coat microballoon is simple, compact, and occupied area is small, is suitble to microballoon coated
Produce in enormous quantities, high production efficiency is high-quality.
Detailed description of the invention
Fig. 1 is overall structure diagram of the invention.
Fig. 2 is isocon structural schematic diagram of the invention.
In figure: 1 first tank body, 3 microballoon tanks, 4 condensing agent tanks, 2 second tank bodies, 5 antibody or antigenic solution tank, 6 buffers
Tank, 7 first air inlet pipe, 8 general pipeline, 9 isocons, 10 summarize be in charge of, 11 filtering tanks, 12 filter membranes, 13 gas-distributing pipes, 14 heating layers,
15 temperature sensors, 16 inlet manifolds, 17 blowers, 18 sewage pipes, 19 drainage conduits, 20 second air inlet pipe.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
Embodiment 1:
The present invention provides a kind of continuous preparation method of antibody (or antigen) coating microballoon, the specific preparation steps
It is as follows:
Step 1: preparation microballoon, antibody or antigenic solution, condensing agent and buffer first；
Step 2: the condensing agent in the microballoon and condensing agent tank 4 in microballoon tank 3 is pumped by first pressure and pipeline injects
It is mixed in first tank body 1, antibody or antibody in antigenic solution tank 5 or the buffer in antigenic solution and buffering flow container 6
It is injected in the second tank body 2 and is mixed by first pressure pump and pipeline；
Step 3: being equipped with the first air inlet pipe 7 in the first tank body 1 and the second tank body 2, worked by blower 17, gas pass through into
Gas general pipeline 16 is blown to the 13 heated layer 14 in inside of gas-distributing pipe and heats, and then passes through the first air inlet pipe 7 to the first tank body 1 and the second tank
Hot gas is passed through in body 2, generating bubble is uniformly mixed liquid；
Step 4: and then passed through the mixing liquid in the first tank body 1 and in the second tank body 2 respectively by second pressure pump
In multiple inclined isocons 9 of the fan-shaped distribution of 8 filling main of general pipeline, the 8 bottom connection of left and right settings, liquid is through two sides
Isocon 9 shunt respectively after, summarizing to be in charge of in 10 and mixed into middle part；
Step 5: the pressure for the liquid that mixed liquid is constantly entered in step 3 and it is aggregated be in charge of 10 upwards
Conveying in transmission process, summarizes and is in charge of 10 inside and is passed through hot gas by the second air inlet pipe 20, generate bubble and simultaneously heat mixed liquor
Body, accelerates the association reaction of microballoon and antibody or antigenic solution, and is uniformly mixed mitigation liquid, makes locating for each microballoon
Surrounding enviroment are identical；
Step 6: when mixing liquid is delivered in the filtering tank 11 for summarizing and being in charge of at the top of 10, two sides in filtering tank 11 are flow to
The filter membrane 12 being obliquely installed on impurity screening, impurity is discharged through the sewage pipe 18 of 11 side of filtering tank, and obtained coating is micro-
Ball warp drainage conduit 19 is discharged.
By being passed through hot-air by air inlet pipe in liquid mixed process, not only mix liquid more uniform, and
And can be heated to mixing liquid, accelerate the speed and efficiency of antibody or antigen coat microballoon, keeps microballoon coating more preferable, and add
Work step is suddenly simple, can constantly serialization prepare, high in machining efficiency, can be suitable for producing in enormous quantities.
Embodiment 2:
The present invention also provides a kind of serialization preparation facilities of antibody (or antigen) as shown in Figure 1 coating microballoon, institutes
It states and microballoon tank 3 and condensing agent tank 4 is connected with by pipeline at the top of the first tank body 1, the pipeline is equipped with pressure pump, and described second
It is connected with by pipeline equipped with antibody or antigenic solution tank 5 and buffer tank 6, first tank body 1 and the second tank at the top of tank body 2
It is equipped with the first air inlet pipe 7 inside body 2, general pipeline 8 is equipped on the inside of first tank body 1 and the second tank body 2, is set on the general pipeline 8
There is a second pressure pump, 8 end general pipeline is fixed with isocon 9, and 9 bottom of isocon, which is equipped with to summarize, is in charge of 10, described
Summarize to be in charge of at the top of 10 and be equipped with filtering tank 11, filter membrane 12 is equipped with inside the filtering tank 11.
Further, in the above-mentioned technical solutions, gas-distributing pipe is equipped at the top of first air inlet pipe 7 and the second air inlet pipe 20
13,13 inner wall of gas-distributing pipe is equipped with heating layer 14, and the heating layer 14 includes heater strip, is equipped with temperature inside the gas-distributing pipe 13
Sensor 15 is spent, inlet manifold 16 is equipped at the top of the gas-distributing pipe 13, the inlet manifold 16 is equipped with blower 17, temperature sensing
Device 15 is able to detect heating temperature, the heating temperature of intelligent control gas is capable of by device external computer terminal, to control
The heating temperature of internal solution.
Further, in the above-mentioned technical solutions, 11 side of filtering tank corresponding with filter membrane 12 is equipped with sewage pipe
18,11 bottom of filtering tank is equipped with drainage conduit 19, and the filter membrane 12 is set as multilayer and section is disposed as annular, convenient
Filtering.
A kind of serialization preparation facilities of antibody (or antigen) coating microballoon according to Fig.2, the isocon 9 are arranged
For multiple and fan-shaped distribution, the isocon 9 is set as skewed, it is described summarize be in charge of 10 and first tank body 1 and the second tank
The isocon 9 of 2 inside of body corresponds and integrated molding, can be realized mixed solution shunting mixing, avoid large capacity
Solution mixing causes liquid to be difficult to be uniformly mixed, and is difficult to grasp to each microballoon surrounding enviroment.
Finally, it should be noted that the foregoing is only a preferred embodiment of the present invention, it is not intended to restrict the invention,
Although the present invention is described in detail referring to the foregoing embodiments, for those skilled in the art, still may be used
To modify the technical solutions described in the foregoing embodiments or equivalent replacement of some of the technical features,
All within the spirits and principles of the present invention, any modification, equivalent replacement, improvement and so on should be included in of the invention
Within protection scope.
Claims (5)
1. a kind of continuous preparation method of antibody (or antigen) coating microballoon, it is characterised in that: the specific preparation step is such as
Under:
Step 1: preparation microballoon, antibody or antigenic solution, condensing agent and buffer first；
Step 2: the condensing agent in the microballoon and condensing agent tank in microballoon tank is pumped by first pressure and pipeline injects the first tank
It is mixed in vivo, antibody or antibody in antigenic solution tank or the buffer in antigenic solution and buffering flow container pass through the first pressure
Power pump and pipeline, which inject in the second tank body, to be mixed；
Step 3: it is equipped with the first air inlet pipe in the first tank body and the second tank body, is worked by blower, gas is blown to through inlet manifold
Heated layer heating, is then passed through hot gas into the first tank body and the second tank body by the first air inlet pipe, generates inside gas-distributing pipe
Bubble is uniformly mixed liquid；
Step 4: and then will pass through respectively left and right with the intracorporal mixing liquid of the second tank in the first tank body by second pressure pump and set
In multiple inclined isocons of the fan-shaped distribution for the general pipeline filling main bottom connection set, the translateral isocon of liquid point
Not Fen Liu after, be in charge of interior mixed into summarizing for middle part；
Step 5: the pressure for the liquid that mixed liquid is constantly entered in step 3 and it is aggregated be in charge of be delivered up,
In transmission process, summarize be in charge of it is internal hot gas is passed through by the second air inlet pipe, generate bubble and simultaneously heat mixing liquid, quickening microballoon
With the association reaction of antibody or antigenic solution, and make mitigate liquid be uniformly mixed, make surrounding enviroment phase locating for each microballoon
Together；
Step 6: mixing liquid is delivered to when summarizing in the filtering tank for being in charge of top, flow to being obliquely installed for two sides in filtering tank
Filter membrane on impurity screening, impurity is discharged through the sewage pipe of filtering tank side, and obtained coating microballoon is discharged through drainage conduit.
2. a kind of serialization preparation facilities of antibody (or antigen) coating microballoon according to claim, it is characterised in that:
First top of the tank is connected with microballoon tank and condensing agent tank by pipeline, and the pipeline is equipped with pressure pump, and described second
Top of the tank is connected with by pipeline equipped with antibody or antigenic solution tank and buffer tank, in first tank body and the second tank body
Portion is equipped with the first air inlet pipe, and general pipeline is equipped on the inside of first tank body and the second tank body, and the general pipeline is equipped with second pressure
Pump, total tube end are fixed with isocon, and the shuntings bottom of the tube, which is equipped with to summarize, to be in charge of, it is described summarize be in charge of at the top of be equipped with
Filtering tank, the filtering tank inside are equipped with filter membrane.
3. a kind of continuous preparation method of antibody (or antigen) coating microballoon according to claim, it is characterised in that:
Gas-distributing pipe is equipped at the top of first air inlet pipe and the second air inlet pipe, the gas-distributing pipe inner wall is equipped with heating layer, the heating layer
Including heater strip, it is equipped with temperature sensor inside the gas-distributing pipe, is equipped with inlet manifold at the top of the gas-distributing pipe, the air inlet is total
Pipe is equipped with blower.
4. a kind of continuous preparation method of antibody (or antigen) coating microballoon according to claim, it is characterised in that:
The isocon is set as multiple and fan-shaped distribution, and the isocon is set as skewed, it is described summarize be in charge of and the first tank
Isocon on the inside of body and the second tank body corresponds and integrated molding.
5. a kind of continuous preparation method of antibody (or antigen) coating microballoon according to claim, it is characterised in that:
Filtering tank corresponding with the filter membrane side is equipped with sewage pipe, and the filtering pot bottom is equipped with drainage conduit, and the filter membrane is set
It is set to multilayer and section is disposed as annular.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810416852.7A CN109030810A (en) | 2018-05-03 | 2018-05-03 | A kind of continuous preparation method of antibody (or antigen) coating microballoon |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810416852.7A CN109030810A (en) | 2018-05-03 | 2018-05-03 | A kind of continuous preparation method of antibody (or antigen) coating microballoon |
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| Publication Number | Publication Date |
|---|---|
| CN109030810A true CN109030810A (en) | 2018-12-18 |
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ID=64611313
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810416852.7A Withdrawn CN109030810A (en) | 2018-05-03 | 2018-05-03 | A kind of continuous preparation method of antibody (or antigen) coating microballoon |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110244038A (en) * | 2019-06-20 | 2019-09-17 | 武汉纳达康生物科技有限公司 | A kind of biomolecule flow maker reaction technology and reaction unit |
-
2018
- 2018-05-03 CN CN201810416852.7A patent/CN109030810A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110244038A (en) * | 2019-06-20 | 2019-09-17 | 武汉纳达康生物科技有限公司 | A kind of biomolecule flow maker reaction technology and reaction unit |
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Application publication date: 20181218 |