CN108896489A - A kind of acousto-optic imaging method and device - Google Patents
A kind of acousto-optic imaging method and device Download PDFInfo
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/1702—Systems in which incident light is modified in accordance with the properties of the material investigated with opto-acoustic detection, e.g. for gases or analysing solids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
Abstract
This application discloses a kind of acousto-optic imaging method and device, wherein method includes：Emit laser to target to be imaged；The excitation signal that each excitation point generates after being excited in the target to be imaged is received, the corresponding spherical wave complete matrix data of each excitation point are constructed according to the excitation signal；All data in each spherical wave complete matrix data are overlapped, obtain the corresponding imaging data of each excitation point of the target to be imaged, and each imaging data is subjected to image reconstruction and obtains the target image of the target to be imaged.The details of imaging object after solving existing photoacoustic imaging is fuzzy, the poor technical problem of imaging effect.
Description
Technical field
This application involves biomedical and technical field of industrial nondestructive inspection more particularly to a kind of acousto-optic imaging methods and dress
It sets.
Background technique
Object can be excited to generate ultrasonic wave after being irradiated by short-pulse laser, and this phenomenon is referred to as optoacoustic effect.With sharp
The progress of light device technology and supersonic sounding technology, the photoacoustic imaging technology based on this effect have become biomedical imaging field and
One of faster technology is developed in industrial nondestructive testing field.
Photoacoustic imaging utilizes pulsed laser irradiation detection object, and expanded by heating forms instantaneous pressure after tissue resorption light energy
Power generates the ultrasonic signal in a broadband, i.e. photoacoustic signal.Photoacoustic signal obtains tissue light absorption figure via algorithm for reconstructing inverting
Picture, i.e. photoacoustic image.Photoacoustic imaging although have real-time it is good, it is noninvasive, without advantages such as ionising radiation, no pain and low costs,
But its imaging data resolution ratio is not high, so that the imaging object detail after imaging is fuzzy, imaging effect is poor.
Summary of the invention
This application provides a kind of acousto-optic imaging method and devices to solve for biomedical and industrial nondestructive testing
The details of imaging object after existing photoacoustic imaging is fuzzy, the poor technical problem of imaging effect.
In view of this, the application first aspect provides a kind of acousto-optic imaging method, including：
Emit laser to target to be imaged；
The excitation signal that each excitation point generates after being excited in the target to be imaged is received, according to the excitation signal
Construct the corresponding spherical wave complete matrix data of each excitation point；
All data in each spherical wave complete matrix data are overlapped, each of the target to be imaged is obtained
The corresponding imaging data of a excitation point, and each imaging data is subjected to image reconstruction and obtains the mesh of the target to be imaged
Logo image.
Preferably, all data by each spherical wave complete matrix data are overlapped, obtain it is described to
The corresponding imaging data of each excitation point of imageable target, and by each imaging data carry out image reconstruction obtain it is described to
Further include before the target image of imageable target：
It is delayed respectively to each spherical wave complete matrix data by time expander method, the spherical surface after obtaining each delay
Wave complete matrix data；
All data by each spherical wave complete matrix data are overlapped, and obtain the target to be imaged
The corresponding imaging data of each excitation point, and each imaging data is subjected to image reconstruction and obtains the target to be imaged
Target image be specially：
All data in spherical wave complete matrix data after each delay are overlapped, are obtained described to be imaged
Each imaging data progress image reconstruction is obtained the target to be imaged by the corresponding imaging data of each excitation point of target
Target image.
Preferably, described to be delayed respectively to each spherical wave complete matrix data by time expander method, obtain each delay
Spherical wave complete matrix data afterwards specifically include：
It determines the receiving time of each data in each spherical wave complete matrix data, and determines each full square of spherical wave
The reference time of battle array data；
The difference of the reference time and each receiving time are calculated, and using each difference to the difference institute
Data in corresponding spherical wave complete matrix data are delayed, the spherical wave complete matrix data after obtaining each delay.
Preferably, the excitation signal is spherical wave signal.
Preferably, the transmitting laser to target to be imaged specifically includes：
Emit the maximum laser of target absorption coefficient to be imaged to target to be imaged.
The application second aspect provides a kind of opto-acoustic imaging devices, including：
Transmitting unit, for emitting laser to target to be imaged；
Construction unit, for receiving the excitation signal generated after each excitation point is excited in the target to be imaged, root
The corresponding spherical wave complete matrix data of each excitation point are constructed according to the excitation signal；
Processing unit obtains described for being overlapped all data in each spherical wave complete matrix data
The corresponding imaging data of each excitation point of target to be imaged, and by each imaging data carry out image reconstruction obtain it is described
The target image of target to be imaged.
Preferably, described device further includes：Delay unit；
The delay unit is obtained for being delayed respectively to each spherical wave complete matrix data by time expander method
Spherical wave complete matrix data after to each delay；
The processing unit, specifically for by all data in the spherical wave complete matrix data after each delay into
Row superposition, obtains the corresponding imaging data of each excitation point of the target to be imaged, and each imaging data is carried out image weight
It builds to obtain the target image of the target to be imaged.
Preferably, the delay unit specifically includes：
Subelement is determined, for determining the receiving time of each data in each spherical wave complete matrix data, and really
The reference time of fixed each spherical wave complete matrix data；
Be delayed subelement, for calculating the difference of the reference time and each receiving time, and utilizes each institute
It states difference to be delayed to the data in spherical wave complete matrix data corresponding to the difference, the spherical wave after obtaining each delay
Complete matrix data.
Preferably, the excitation signal is spherical wave signal.
Preferably, the excitation unit is specifically used for, and emits the maximum laser of target absorption coefficient to be imaged to be imaged
Target.
As can be seen from the above technical solutions, the embodiment of the present application has the following advantages that：
This application provides a kind of acousto-optic imaging method and device, wherein method includes：Transmitting laser first is to be imaged
Target, each excitation point in target to be imaged can generate excitation signal after being excited, and then receive excitation signal, and according to
Excitation signal constructs the corresponding spherical wave complete matrix data of each excitation point, then after being overlapped to each complete matrix data, obtains
To the corresponding imaging data of each excitation point of target to be imaged, finally by each imaging data progress image reconstruction obtain at
As the target image of target.The application is carried out in the form of complete matrix data rich the excitation signal for generating target to be imaged
It collects richly, so that the imaging data of target to be imaged maximizes, these imaging datas is then recycled to obtain target to be imaged
Target image, substantially increase the resolution ratio and contrast of target image so that obtained target image details is clear, imaging
Effect is good, and the details of the imaging object after solving existing photoacoustic imaging is fuzzy, the poor technical problem of imaging effect.
Detailed description of the invention
Fig. 1 is a kind of flow diagram of the first embodiment of acousto-optic imaging method in the embodiment of the present application；
Fig. 2 is a kind of flow diagram of the second embodiment of acousto-optic imaging method in the embodiment of the present application；
Fig. 3 is a kind of structural schematic diagram of the embodiment of opto-acoustic imaging devices in the embodiment of the present application.
Specific embodiment
The embodiment of the present application provides a kind of acousto-optic imaging method and device, for biomedical and industrial nondestructive testing,
The details of imaging object after solving existing photoacoustic imaging is fuzzy, the poor technical problem of imaging effect.
In order to make those skilled in the art more fully understand application scheme, below in conjunction in the embodiment of the present application
Attached drawing, the technical scheme in the embodiment of the application is clearly and completely described, it is clear that described embodiment is only this
Apply for a part of the embodiment, instead of all the embodiments.Based on the embodiment in the application, those of ordinary skill in the art exist
Every other embodiment obtained under the premise of creative work is not made, shall fall in the protection scope of this application.
Referring to Fig. 1, a kind of flow diagram of the first embodiment of acousto-optic imaging method in the embodiment of the present application, packet
It includes：
Step 101, transmitting laser to target to be imaged.
It should be noted that firstly the need of transmitting laser to target to be imaged during entire photoacoustic imaging.
Step 102 receives the excitation signal that each excitation point generates after being excited in target to be imaged, according to excitation signal
Construct the corresponding spherical wave complete matrix data of each excitation point.
It should be noted that target to be imaged is excited, and receives in target to be imaged after transmitting laser to target to be imaged
The excitation signal that each excitation point generates after being excited constructs the corresponding spherical wave complete matrix of each excitation point according to excitation signal
Data.It is understood that receiving excitation signal can be used phased array probe, specific method of reseptance is：Emit for the first time
For laser to target to be imaged, all excitation points in target to be imaged generate excitation signal, phased array probe after receiving excitation
On each array element receive the excitation signal that each excitation point generates after being excited in target to be imaged, later the 2nd time transmitting swash
Light is to target to be imaged, until n-th excitation, available one group of complete complete matrix data.It should be noted that N is general
Equal to the quantity of array element in popping one's head in.
All data in each spherical wave complete matrix data are overlapped by step 103, obtain each of target to be imaged
The corresponding imaging data of a excitation point, and each imaging data progress image reconstruction is obtained into the target image of target to be imaged.
It should be noted that after constructing the corresponding spherical wave complete matrix data of each excitation point, each spherical wave is complete
All data in matrix data are overlapped, and obtain the corresponding imaging data of each excitation point of target to be imaged, the i.e. point
Detected amplitude, the pixel value of the corresponding namely point, and by each imaging data progress image reconstruction obtain mesh to be imaged
Target target image.
In the present embodiment, to target to be imaged, each excitation point in target to be imaged is being excited transmitting laser first
After can generate excitation signal, then receive excitation signal, and it is complete according to excitation signal to construct the corresponding spherical wave of each excitation point
Matrix data, then after being overlapped to each complete matrix data, obtain the corresponding imaging number of each excitation point of target to be imaged
According to, finally by each imaging data progress image reconstruction obtain the target image of target to be imaged.The application passes through will be to be imaged
The excitation signal that target generates galore is collected in the form of complete matrix data, so that the imaging data of target to be imaged is most
Then bigization recycles these imaging datas to obtain the target image of target to be imaged, substantially increase the resolution of target image
Rate and contrast, so that obtained target image details is clear, imaging effect is good, the imaging object after solving existing photoacoustic imaging
Details it is fuzzy, the poor technical problem of imaging effect.
The above are a kind of first embodiments of acousto-optic imaging method provided by the embodiments of the present application, and the following are the application implementations
A kind of second embodiment for acousto-optic imaging method that example provides.
Referring to Fig. 2, a kind of flow diagram of the second embodiment of acousto-optic imaging method in the embodiment of the present application, packet
It includes：
Step 201, the transmitting maximum laser of target absorption coefficient to be imaged to target to be imaged.
It should be noted that by emitting the maximum laser of target absorption coefficient to be imaged to target to be imaged, make at
As target issues excitation signal.
Step 202 receives the excitation signal that each excitation point generates after being excited in target to be imaged, according to excitation signal
Construct the corresponding spherical wave complete matrix data of each excitation point.
It should be noted that excitation signal is spherical wave signal, spherical wave signal is not easy to decay in transmission process.
Step 203 is respectively delayed to each spherical wave complete matrix data by time expander method, after obtaining each delay
Spherical wave complete matrix data.
It should be noted that in order to enable the imaging data of each excitation point maximizes, it can be right respectively by time expander method
Each spherical wave complete matrix data are delayed, the spherical wave complete matrix data after obtaining each delay.
It is delayed respectively to each spherical wave complete matrix data by time expander method, the spherical wave after obtaining each delay is complete
Matrix data specifically includes：It determines the receiving time of each data in each spherical wave complete matrix data, and determines each spherical surface
The reference time of wave complete matrix data；The difference of reference time and each receiving time are calculated, and using each difference to the difference
Data in the corresponding spherical wave complete matrix data of value are delayed, the spherical wave complete matrix data after obtaining each delay.
Determine that each array element receives the receiving time of the excitation signal of some excitation point sending, then first with the reception of one of array element
The time for the excitation signal that the excitation point issues is the reference time, then calculates the difference of reference time and each receiving time, and
It is delayed using each difference to the data in spherical wave complete matrix data corresponding to the difference, after obtaining each delay
Spherical wave complete matrix data.
All data in spherical wave complete matrix data after each delay are overlapped by step 204, are obtained to be imaged
Each imaging data progress image reconstruction is obtained the target of target to be imaged by the corresponding imaging data of each excitation point of target
Image.
It should be noted that after the spherical wave complete matrix data after being delayed, the spherical wave after each delay is complete
All data in matrix data are overlapped, and obtain the corresponding imaging data of each excitation point of target to be imaged, the i.e. point
Detected amplitude, the pixel value of the corresponding namely point, by each imaging data progress image reconstruction obtain target to be imaged
Target image.
In the present embodiment, to target to be imaged, each excitation point in target to be imaged is being excited transmitting laser first
After can generate excitation signal, then receive excitation signal, and it is complete according to excitation signal to construct the corresponding spherical wave of each excitation point
Matrix data, then after being overlapped to each complete matrix data, obtain the corresponding imaging number of each excitation point of target to be imaged
According to, finally by each imaging data progress image reconstruction obtain the target image of target to be imaged.The application passes through will be to be imaged
The excitation signal that target generates galore is collected in the form of complete matrix data, so that the imaging data of target to be imaged is most
Then bigization recycles these imaging datas to obtain the target image of target to be imaged, substantially increase the resolution of target image
Rate and contrast, so that obtained target image details is clear, imaging effect is good, the imaging object after solving existing photoacoustic imaging
Details it is fuzzy, the poor technical problem of imaging effect.
The above are a kind of second embodiments of acousto-optic imaging method provided by the embodiments of the present application, and the following are the application implementations
A kind of application examples for acousto-optic imaging method that example provides.
Step 1: determining that target to be imaged is the angiocarpy of mouse heart.Determine that mouse angiocarpy is to wavelength first
The absorption of the laser of 532nm or so is preferable, and the noise of the excitation signal after excitation is relatively high.
Step 2: launch wavelength is 532nm laser to mouse heart.
Step 3: receiving the excitation signal after mouse heart is excited using phased array probe.
Step 4: the angiocarpy of mouse is imaged by way of the image reconstruction that is delayed again.
The above are a kind of application examples of acousto-optic imaging method provided by the embodiments of the present application, and the following are the embodiment of the present application to mention
A kind of embodiment of the opto-acoustic imaging devices supplied.
Referring to Fig. 3, a kind of structural schematic diagram of the embodiment of opto-acoustic imaging devices in the embodiment of the present application, including：
Transmitting unit 301, for emitting laser to target to be imaged；
Construction unit 302, for receiving the excitation signal generated after each excitation point is excited in target to be imaged, according to
Excitation signal constructs the corresponding spherical wave complete matrix data of each excitation point；
Processing unit 303 obtains to be imaged for being overlapped all data in each spherical wave complete matrix data
The corresponding imaging data of each excitation point of target, and each imaging data progress image reconstruction is obtained into the mesh of target to be imaged
Logo image.
Further, which further includes：Delay unit 304, for passing through time expander method respectively to the full square of each spherical wave
Battle array data are delayed, the spherical wave complete matrix data after obtaining each delay；
Processing unit 303, specifically for folding all data in the spherical wave complete matrix data after each delay
Add, obtain the corresponding imaging data of each excitation point of target to be imaged, by each imaging data progress image reconstruction obtain to
The target image of imageable target.
Further, delay unit 304 specifically includes：
Subelement 3041 is determined, for determining the receiving time of each data in each spherical wave complete matrix data, and really
The reference time of fixed each spherical wave complete matrix data；
Be delayed subelement 3042, for calculating the difference of reference time and each receiving time, and utilizes each difference pair
Data in spherical wave complete matrix data corresponding to the difference are delayed, the spherical wave complete matrix number after obtaining each delay
According to.
Further, excitation signal is spherical wave signal.
Further, excitation unit 301 is specifically used for, and emits the maximum laser of target absorption coefficient to be imaged to be imaged
Target.
It is apparent to those skilled in the art that for convenience and simplicity of description, the system of foregoing description,
The specific work process of device and unit, can refer to corresponding processes in the foregoing method embodiment, and details are not described herein.
The description of the present application and term " first " in above-mentioned attached drawing, " second ", " third ", " the 4th " etc. are (if deposited
) it is to be used to distinguish similar objects, without being used to describe a particular order or precedence order.It should be understood that use in this way
Data are interchangeable under appropriate circumstances, so that embodiments herein described herein for example can be in addition to illustrating herein
Or the sequence other than those of description is implemented.In addition, term " includes " and " having " and their any deformation, it is intended that
Cover it is non-exclusive include, for example, containing the process, method, system, product or equipment of a series of steps or units need not limit
In step or unit those of is clearly listed, but may include be not clearly listed or for these process, methods, produce
The other step or units of product or equipment inherently.
It should be appreciated that in this application, " at least one (item) " refers to one or more, and " multiple " refer to two or two
More than a."and/or" indicates may exist three kinds of relationships, for example, " A and/or B " for describing the incidence relation of affiliated partner
It can indicate：A is only existed, B is only existed and exists simultaneously tri- kinds of situations of A and B, wherein A, B can be odd number or plural number.Word
Symbol "/" typicallys represent the relationship that forward-backward correlation object is a kind of "or"." at least one of following (a) " or its similar expression, refers to
Any combination in these, any combination including individual event (a) or complex item (a).At least one of for example, in a, b or c
(a) can indicate：A, b, c, " a and b ", " a and c ", " b and c ", or " a and b and c ", wherein a, b, c can be individually, can also
To be multiple.
In several embodiments provided herein, it should be understood that disclosed device and method can pass through it
Its mode is realized.For example, the Installation practice described above is only schematical, for example, the unit is drawn
Point, only a kind of logical function partition, there may be another division manner in actual implementation, such as multiple units or components can
To combine or be desirably integrated into another system, or some features can be ignored or not executed.Another point, it is shown or beg for
The mutual coupling, direct-coupling or communication connection of opinion can be through some interfaces, the INDIRECT COUPLING of device or unit
Or communication connection, it can be electrical property, mechanical or other forms.
The unit as illustrated by the separation member may or may not be physically separated, aobvious as unit
The component shown may or may not be physical unit, it can and it is in one place, or may be distributed over multiple
In network unit.It can select some or all of unit therein according to the actual needs to realize the mesh of this embodiment scheme
's.
It, can also be in addition, each functional unit in each embodiment of the application can integrate in one processing unit
It is that each unit physically exists alone, can also be integrated in one unit with two or more units.Above-mentioned integrated list
Member both can take the form of hardware realization, can also realize in the form of software functional units.
If the integrated unit is realized in the form of SFU software functional unit and sells or use as independent product
When, it can store in a computer readable storage medium.Based on this understanding, the technical solution of the application is substantially
The all or part of the part that contributes to existing technology or the technical solution can be in the form of software products in other words
It embodies, which is stored in a storage medium, including some instructions are used so that a computer
Equipment (can be personal computer, server or the network equipment etc.) executes the complete of each embodiment the method for the application
Portion or part steps.And storage medium above-mentioned includes：USB flash disk, mobile hard disk, read-only memory (full name in English：Read-Only
Memory, english abbreviation：ROM), random access memory (full name in English：Random Access Memory, english abbreviation：
RAM), the various media that can store program code such as magnetic or disk.
The above, above embodiments are only to illustrate the technical solution of the application, rather than its limitations；Although referring to before
Embodiment is stated the application is described in detail, those skilled in the art should understand that：It still can be to preceding
Technical solution documented by each embodiment is stated to modify or equivalent replacement of some of the technical features；And these
It modifies or replaces, the spirit and scope of each embodiment technical solution of the application that it does not separate the essence of the corresponding technical solution.
Claims (10)
1. a kind of acousto-optic imaging method, which is characterized in that including：
Emit laser to target to be imaged；
The excitation signal that each excitation point generates after being excited in the target to be imaged is received, is constructed according to the excitation signal
The corresponding spherical wave complete matrix data of each excitation point；
All data in each spherical wave complete matrix data are overlapped, each of the target to be imaged is obtained and swashs
The corresponding imaging data of hair point, and each imaging data is subjected to image reconstruction and obtains the target figure of the target to be imaged
Picture.
2. the method according to claim 1, wherein the institute by each spherical wave complete matrix data
There are data to be overlapped, obtain the corresponding imaging data of each excitation point of the target to be imaged, and by each imaging
Data progress image reconstruction obtains：
It is delayed respectively to each spherical wave complete matrix data by time expander method, the spherical wave after obtaining each delay is complete
Matrix data；
All data by each spherical wave complete matrix data are overlapped, and obtain each of the target to be imaged
The corresponding imaging data of a excitation point, and each imaging data is subjected to image reconstruction and obtains the mesh of the target to be imaged
Logo image is specially：
All data in spherical wave complete matrix data after each delay are overlapped, the target to be imaged is obtained
The corresponding imaging data of each excitation point, by each imaging data progress image reconstruction obtain the target of the target to be imaged
Image.
3. according to the method described in claim 2, it is characterized in that, it is described by time expander method respectively to each spherical wave complete matrix
Data are delayed, and the spherical wave complete matrix data after obtaining each delay specifically include：
It determines the receiving time of each data in each spherical wave complete matrix data, and determines each spherical wave complete matrix number
According to reference time；
The difference of the reference time and each receiving time are calculated, and using each difference to corresponding to the difference
Spherical wave complete matrix data in data be delayed, the spherical wave complete matrix data after obtaining each delay.
4. the method according to claim 1, wherein the excitation signal is spherical wave signal.
5. the method according to claim 1, wherein the transmitting laser to target to be imaged specifically includes：
Emit the maximum laser of target absorption coefficient to be imaged to target to be imaged.
6. a kind of opto-acoustic imaging devices, which is characterized in that including：
Transmitting unit, for emitting laser to target to be imaged；
Construction unit, for receiving the excitation signal generated after each excitation point is excited in the target to be imaged, according to institute
It states excitation signal and constructs the corresponding spherical wave complete matrix data of each excitation point；
Processing unit, for all data in each spherical wave complete matrix data to be overlapped, obtain it is described at
As the corresponding imaging data of each excitation point of target, and by each imaging data carry out image reconstruction obtain it is described at
As the target image of target.
7. device according to claim 6, which is characterized in that described device further includes：Delay unit；
The delay unit obtains each for being delayed respectively to each spherical wave complete matrix data by time expander method
Spherical wave complete matrix data after a delay；
The processing unit, specifically for folding all data in the spherical wave complete matrix data after each delay
Add, obtain the corresponding imaging data of each excitation point of the target to be imaged, each imaging data progress image reconstruction is obtained
To the target image of the target to be imaged.
8. device according to claim 7, which is characterized in that the delay unit specifically includes：
It determines subelement, for determining the receiving time of each data in each spherical wave complete matrix data, and determines every
The reference time of a spherical wave complete matrix data；
Be delayed subelement, for calculating the difference of the reference time and each receiving time, and utilizes each difference
Value is delayed to the data in spherical wave complete matrix data corresponding to the difference, the full square of the spherical wave after obtaining each delay
Battle array data.
9. device according to claim 6, which is characterized in that the excitation signal is spherical wave signal.
10. device according to claim 6, which is characterized in that the excitation unit is specifically used for, and emits target to be imaged
The maximum laser of absorption coefficient is to target to be imaged.
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