CN108785434B - Yao medicine composition for chronic urticaria, preparation method thereof and external preparation - Google Patents
Yao medicine composition for chronic urticaria, preparation method thereof and external preparation Download PDFInfo
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Abstract
本发明涉及瑶药领域，提供一种用于慢性荨麻疹的瑶药组合物，包括入山虎1～5份、南蛇风0.5～3份、扛板归0.5～3份、水浸风0.5～3份、鱼腥草1～5份、蛇利草1～5份、大钻0.5～3份和小钻0.5～3份。本发明提供的瑶药组合物基于瑶医理论进行配伍，以入山虎、南蛇风和蛇利草为主药，起到清热解毒、消肿止痒功效；以扛板归、水浸风、大钻和小钻这些打药为配药，起到行气活血、祛风通络之功，祛风则痒止，通络则痛消；以鱼腥草为引路药，引导主药和配药到达病变部位，使其集中在患部进而发挥药物的最大功效。本发明所述瑶药组合物具有显著的止痒消肿、活血通络作用，对慢性荨麻疹的治疗有效率可达到92.31％。The invention relates to the field of Yao medicine, and provides a Yao medicine composition for chronic urticaria, comprising 1-5 parts of Rhizoma Rhizoma, 0.5-3 parts of Southern Snake Wind, 0.5-3 parts of Zaipangui, and 0.5-3 parts of water-soaked wind. 3 parts, 1 to 5 parts of Houttuynia cordata, 1 to 5 parts of She Licao, 0.5 to 3 parts of large diamonds and 0.5 to 3 parts of small diamonds. The Yao medicine composition provided by the present invention is compatible based on the Yao medicine theory, and the main medicines are Rhizoma rhizoma, Rhododendron vulgaris and She Licao, and have the functions of clearing away heat and detoxification, reducing swelling and relieving itching; The big drill and the small drill are used for dispensing, which can activate qi and activate blood, dispel wind and clear collaterals. Expelling wind can relieve itching, and clearing collaterals can relieve pain; Houttuynia cordata is used as a guide medicine to guide the main medicine and the dispensing medicine to reach the lesions. so that it can concentrate on the affected part and exert the maximum effect of the drug. The Yao medicine composition of the present invention has significant effects of relieving itching and swelling, promoting blood circulation and dredging collaterals, and the effective rate of treating chronic urticaria can reach 92.31%.
Description
Technical Field
The invention relates to the field of Yao medicaments, and in particular relates to a Yao medicament composition for chronic urticaria, a preparation method thereof and an external preparation.
Background
Chronic Urticaria (Chronic urtica, CU), mainly manifested by wheal and/or angioedema, occurs at least 2 times per week for a period of > 6 weeks. Causes of urticaria are complicated, wherein specific causes of urticaria can be found in acute urticaria, but causes of urticaria chronic is difficult to determine completely, is considered to be related to various factors such as food, medicines, physics, infection, mosquitoes, spirit and working pressure and the like, and can be seen in people of any age, the high-incidence age is 20-40 years old, and the incidence of women is about twice that of men. Most researches show that the incidence of the chronic urticaria has no obvious seasonality and regularity and has no direct correlation with the education degree, occupation, income, residence and moral background. The chronic urticaria has various clinical manifestations, prolonged course of disease, lasting for months or even decades, and recurrent long-term attack of wheal and pruritus, which can affect the work, study, daily activities, social entertainment and other aspects of patients to different degrees, and the life quality of the patients is obviously reduced.
Clinically, the western medicine adopts antihistamine medicines, such as H1 receptor blocking agent, H2 receptor crude breaking agent and the like, sympathomimetic medicines, and calcium and vitamin C as auxiliary materials for treating urticaria. Corticosteroid hormones are often used for chronic urticaria with severe episodes. Although the western medicine for treating chronic urticaria has quick response and strong effect, the state of illness is easy to repeat after the medicine is stopped, and the western medicine is often accompanied by great toxic and side effects.
The Yao nationality living wide mountainous areas are called plant kingdom as a material, are natural medicine producing areas, can use local materials for fresh medicines, do not need processing and storage, simultaneously have no damage to the active ingredients of the fresh medicines, and have better curative effect than dry medicines. The toxic herbs are also processed by proper methods, for example, ban Xia should be detoxified by the processing method of Chinese herbs. Yao nationality medicine also adopts non-medicine treatment (such as medicated bath, cupping, pricking, fire moxibustion, etc.), and regulates and promotes organism's balance between profit and deficiency', so as to achieve the purposes of treating diseases, strengthening body and building body.
Chronic urticaria belongs to the field of Yao medicine 'suan' disease, and is mainly caused by consumptive disease, deficiency of primordial qi, internal generation of toxin, or body weakness complicated with wind, dampness and heat (fire) toxin, toxin invasion into veins, triple detuning, imbalance of excess and deficiency of qi and blood, no change of qi and blood, invasion of pathogenic qi into vessels, blockage of tendons and vessels, qi circulation stasis, inward arrival of toxin at viscera and outward penetration of skin into orifices to induce the disease. The conventional Yao medicine treatment needs to be carried out on symptoms, is relatively complicated and cannot be popularized and applied on a large scale.
Disclosure of Invention
The invention provides a Yao medicine composition for treating chronic urticaria, which aims to solve the problem of unobvious curative effect of a medicine for treating chronic urticaria in the prior art, and has the advantages of high treatment effective rate, quick response and convenience in use.
In order to solve the above problems, the present invention provides the following technical solutions:
the invention provides a Yao medicine composition for chronic urticaria, which comprises the following raw materials in parts by weight: 1 to 5 parts of tiger, 0.5 to 3 parts of south snake wind, 0.5 to 3 parts of perfoliate knotweed herb, 0.5 to 3 parts of water immersion wind, 1 to 5 parts of heartleaf houttuynia herb, 1 to 5 parts of common bur herb, 0.5 to 3 parts of big bur and 0.5 to 3 parts of small bur.
Preferably, the raw materials comprise: 2 parts of Japanese rockfoil herb, 1 part of south snake wind, 1 part of perfoliate knotweed herb, 1 part of water soaking wind, 2 parts of heartleaf houttuynia herb, 2 parts of common hop herb, 1 part of rhinestone and 1 part of small rhinestone.
The invention provides a preparation method of the Yao medicine composition, which comprises the following steps:
respectively crushing and mixing the raw materials to obtain mixed powder;
and drying the mixed powder to obtain the Yao medicine composition.
Preferably, the pulverized particle size of the raw materials is independently 18 to 35 mesh.
Preferably, the drying is infrared drying.
The invention also provides an external preparation for chronic urticaria, which comprises the Yao medicine composition and pharmaceutic adjuvant in the technical scheme.
Preferably, the mass ratio of the Yao medicine composition to the pharmaceutical excipients is 8-18: 2-7.
Preferably, the pharmaceutic adjuvant comprises one or more of an excipient, a solvent, a cosolvent and a transdermal absorption enhancer.
Preferably, the external preparation is in a form selected from liniment, paste, tincture, powder, aerosol, plastics or paste.
Preferably, when the formulation of the external preparation is a liniment, the solvent is iodine.
Compared with the prior art, the technical scheme provided by the invention has the following advantages:
the invention provides a Yao medicine composition for chronic urticaria, which comprises the following raw materials in parts by weight: 1 to 5 parts of tiger, 0.5 to 3 parts of south snake wind, 0.5 to 3 parts of perfoliate knotweed herb, 0.5 to 3 parts of water immersion wind, 1 to 5 parts of heartleaf houttuynia herb, 1 to 5 parts of common bur herb, 0.5 to 3 parts of big bur and 0.5 to 3 parts of small bur. The Yao medicine composition provided by the invention is compatible based on Yao medicine theory, takes the mountain tiger, the south snake wind and the serpentium as main medicines, and has the effects of clearing away heat and toxic materials, relieving swelling and itching; the medicines of perfoliate knotweed herb, water soaked wind, rhinestone and rhinestone are used as the medicines to play the roles of promoting the circulation of qi and blood, dispelling wind and removing obstruction in channels, and the dispelling wind can stop itching and remove pain and pain when removing obstruction in channels; the houttuynia cordata is used as a guiding drug to guide the main drug and the prepared drug to reach the diseased region, so that the main drug and the prepared drug are concentrated on the diseased region to exert the maximum efficacy of the drug. The Yao medicine composition compatible with the traditional Chinese medicine composition has the remarkable effects of relieving itching and swelling, promoting blood circulation and removing meridian obstruction, and the effective rate of treating chronic urticaria can reach 92.31%.
The invention also provides an external preparation for chronic urticaria, which comprises the Yao medicine composition and pharmaceutic adjuvants in the technical scheme. The external preparation provided by the invention is simple and convenient to apply, has an obvious curative effect on chronic urticaria, and is beneficial to large-scale popularization and application.
Detailed Description
The invention provides a Yao medicine composition for chronic urticaria, which comprises the following raw materials in parts by weight: 1 to 5 parts of tiger, 0.5 to 3 parts of south snake wind, 0.5 to 3 parts of perfoliate knotweed herb, 0.5 to 3 parts of water immersion wind, 1 to 5 parts of heartleaf houttuynia herb, 1 to 5 parts of common bur herb, 0.5 to 3 parts of big bur and 0.5 to 3 parts of small bur. The preferable raw materials of the invention comprise 2 parts of Japanese rockfoil herb, 1 part of south snake wind, 1 part of perfoliate knotweed herb, 1 part of water soaked wind, 2 parts of heartleaf houttuynia herb, 2 parts of common hop herb, 1 part of rhinestone and 1 part of small rhinestone.
Mountain tiger: also named as radix Zanthoxyli and Zanthoxylum piperitum, which is bitter and pungent in flavor and warm in nature, is the dry root and stem of Zanthoxylum nitidum of Rutaceae. The Yao medicine composition provided by the invention is a main medicine, and belongs to the field of medicine application, heat clearing and detoxifying, swelling and pain relieving, blood circulation activating and blood stasis dissipating.
South snake wind: also named as Laoyu pillow and bitter Shilian, is bitter in taste and cool in nature, and is a whole plant of Caesalpinia coracoid of Leguminosae. The Yao medicine composition provided by the invention is a main medicine, belongs to a wind medicine, and has the effects of clearing heat, promoting diuresis, relieving swelling and pain, killing parasites and relieving itching.
The Chinese lizardtail herb: bian Lian, sweet and light in flavor and cool in nature, is the whole herb with root of Lo Lian of Campanulaceae. The Yao medicine composition provided by the invention is a main medicine, belongs to wind medicine, and has the effects of clearing heat and removing toxicity, inducing diuresis to reduce edema, promoting blood circulation to stop pain, dispelling wind and removing blood stasis.
The invention takes the rhizome of Japanese rockfoil, the south snakegourd wind and the herba selaginellae as main medicines, and the wind-medicine and the laxative are mutually matched to play the effects of clearing heat and removing toxicity, and relieving swelling and itching.
The lever plate is classified as follows: has sour and mild taste and cold property, and is the whole herb of herba Hyperici perforati of Polygonaceae. The Yao medicine composition disclosed by the invention is a dosage, and belongs to the field of laxatives, diuresis inducing and detumescence, heat clearing, blood circulation activating and detoxification.
Water immersion and air blowing: bitter in taste and cool in nature, and is a whole herb of Polygonum hydropiper of Polygonaceae. The Yao medicine composition disclosed by the invention is a dosage, and belongs to the field of medicine injection, clearing heat and eliminating dampness, regulating lung and reducing phlegm, and relieving swelling and pain.
Drilling a big hole: also named as Diesmus, Tuanshanxiang and rice ball, is pungent, slightly bitter and warm in nature, and is the root bark or root of the rice ball of Schisandraceae. The Yao medicine composition provided by the invention is used for dispensing medicines and also used for laxative, promoting qi and blood circulation, dispelling wind and activating collaterals, and removing blood stasis and relieving pain.
Drilling a small drill: also called Kadsura longepedunculata, ZU GU FENG, and CU JING ENJI, are the roots and stems of Kadsura longepedunculata of Schisandraceae. The Yao medicine composition provided by the invention is used as a medicine preparation and also used as a laxative, and has the effects of invigorating spleen and tonifying kidney, regulating qi and activating blood circulation, dispelling wind and dredging collaterals, and relieving swelling and pain.
According to the invention, four types of laxatives including perfoliate knotweed herb, water soaked wind, rhinestone and rhinestone are selected as the medicines for dispensing, so that the effects of promoting qi and activating blood circulation, dispelling wind and dredging collaterals are achieved, itching is relieved when the wind is dispelled, and pain is relieved when the collaterals are dredged, the main effects of relieving swelling and itching are enhanced by using the laxatives for promoting qi and activating blood circulation, dispelling wind and dredging collaterals, and the medicine time can be effectively accelerated, so that the Yao medicine composition disclosed by the invention can quickly relieve the symptoms of chronic urticaria and reduce the pain of patients.
Houttuynia cordata: has pungent taste and cool property, and is fresh whole herb or dried aerial part of houttuynia cordata of Saururaceae. The Yao medicine composition provided by the invention is a guiding medicine and a wind medicine, and has the effects of clearing away heat and toxic materials, inducing diuresis and relieving swelling.
The invention takes the cordate houttuynia as the guiding drug to guide the drug effect of the main drug and the prepared drug to directly reach the patient, thereby exerting the maximum drug effect of the drug.
The raw materials are compatible through the Yao medicine theory, the effects of relieving swelling and pain, promoting blood circulation and removing meridian obstruction are achieved, and the effective rate of the external medicine for treating chronic urticaria is up to more than 92%.
The invention has no special limitation on the sources of the raw materials such as the tiger, the south snake wind, the serpentium and the like, and the Yao medicine raw materials known in the field are adopted.
The invention also provides a preparation method of the Yao medicine composition for chronic urticaria, which comprises the following steps:
respectively crushing the raw materials of the Yao medicine composition, mixing, and drying to obtain the Yao medicine composition.
According to the invention, the solid raw materials of the externally-applied Yao medicine composition are preferably cleaned and dried before the grinding. In the present invention, the drying method is preferably drying in the sun.
In the present invention, the particle size of the pulverized raw material is independently 18 to 35 mesh, and more preferably 20 mesh. The crushing method is not particularly limited, and the technical scheme of crushing the traditional Chinese medicinal materials, which is well known by the technical personnel in the field, can be adopted. The present invention is not limited to the pulverization of the raw materials, but is not limited to the pulverization of the raw materials into the same particle size.
According to the invention, the respectively crushed raw materials are mixed, and the mixed raw materials are dried, so that the Yao medicine composition is obtained. In the invention, the mixed raw materials are preferably dried until the water content is lower than 10%, and more preferably 6-8%. The infrared drying method is preferably used for drying, and the method has small damage to effective substances in the raw materials and is beneficial to retaining more effective substances. The specific infrared drying conditions are not particularly limited, as long as the mixed raw materials can be dried until the water content is lower than 10%, and the specific conditions can be determined according to the water content of the raw materials.
The invention also provides an external preparation for chronic urticaria, which comprises the Yao medicine composition and pharmaceutic adjuvant in the technical scheme.
In the invention, the mass ratio of the Yao medicine composition to the pharmaceutic adjuvant is preferably 8-18: 2-7, and more preferably 10-12: 3-5.
The pharmaceutic adjuvant disclosed by the invention is any pharmaceutic adjuvant capable of being used for preparing external drugs, and the type and the quantity of the required adjuvants can be selected by a person skilled in the art according to the dosage form of the drugs, wherein the adjuvants comprise but are not limited to adhesives, lubricants, solvents, preservatives, aromatics, cosolvents, emulsifiers, solubilizers, colorants, matrixes and transdermal absorption enhancers. The sources of the pharmaceutical excipients are not limited in any way, and the raw materials are commercially available, which are well known to those skilled in the art. The dosage proportion of various pharmaceutic adjuvants is not specially limited, and the invention can be prepared by adopting a proper preparation form.
In the present invention, the dosage form of the external preparation includes, but is not limited to, liniment, ointment, tincture, powder, aerosol, plastics or paste. The specific preparation method of the preparation is not particularly limited, and the preparation method is based on the known preparation method of the external preparation in the field, and the pharmaceutical excipients are selected and prepared.
According to the invention, the external preparation for treating chronic urticaria is preferably a liniment, and the pharmaceutical adjuvant is preferably iodine.
When the external preparation provided by the invention is used for chronic urticaria, the external preparation is coated on an affected part, and active ingredients in the external preparation enter a body through transdermal absorption and play a quick and effective treatment role.
In order to further illustrate the present invention, the following embodiments are described in detail, but they should not be construed as limiting the scope of the present invention.
Example 1
Taking the following solid raw materials in parts by weight: adding 2 parts of Japanese rockfoil herb, 1 part of south snake wind, 1 part of perfoliate knotweed herb, 1 part of water soaking wind, 2 parts of heartleaf houttuynia herb, 2 parts of common hop herb, 1 part of rhinestone and 1 part of small rhinestone, respectively cleaning, drying in the sun, crushing to 20 meshes, mixing, and performing infrared drying for 7 hours to obtain the Yao medicine composition for chronic urticaria.
Example 2
Taking the following solid raw materials in parts by weight: adding 1 part of Japanese rockfoil herb, 0.5 part of south snake wind, 1 part of perfoliate knotweed herb, 2 parts of water soaked wind, 1 part of heartleaf houttuynia herb, 3 parts of spreading hedyotis herb, 1 part of rhinestone and 1.5 parts of small rhinestone, respectively cleaning, drying in the sun, crushing to 18 meshes, mixing, and carrying out infrared drying for 5 hours to obtain the Yao medicine composition for chronic urticaria.
Example 3
Taking the following solid raw materials in parts by weight: adding 5 parts of Japanese rockfoil herb, 2 parts of south snake wind, 2 parts of perfoliate knotweed herb, 2.5 parts of water soaking wind, 2 parts of heartleaf houttuynia herb, 1.5 parts of spreading hedyotis herb, 0.5 part of rhinestone and 0.5 part of small rhinestone, respectively cleaning, drying in the sun, crushing to 18 meshes, mixing, and carrying out infrared drying for 3 hours to obtain the Yao medicine composition for chronic urticaria.
Example 4
11 parts of the Yao medicine composition prepared in example 1 is mixed with 4 parts of iodine tincture to obtain the external liniment for chronic urticaria.
Example 5
And (3) mixing 16 parts of the Yao medicine composition prepared in the example 2 with 7 parts of iodine tincture to obtain the external liniment for chronic urticaria.
Example 6
12 parts of the Yao medicine composition prepared in example 3 are mixed with 3 parts of vaseline to obtain an external ointment for chronic urticaria.
Example 7
The number of patients with chronic urticaria is 52 in the first subsidiary hospital of Guangxi Chinese medicine university. The selected patients were divided into treatment groups and control groups according to a random number table, and 26 patients were administered to each group.
1. Case selection
All patients met the diagnostic criteria of "chronic urticaria" in "clinical dermatology (Zhao Zhang. clinical dermatology [ M ].3 edition. Nanjing: Jiangsu scientific and technological Press, 2001: 612).
2. Exclusion criteria:
pregnant or lactating women; those allergic to H1 receptor antagonists; serious liver and kidney diseases, autoimmune system diseases, diabetes, mental diseases, combined cardiovascular and respiratory symptoms, and the like; patients who are not dosed according to the prescription, withdraw from the prescription midway, and can not judge the curative effect or the data is not complete and the curative effect or the safety judgment is influenced.
3. Treatment regimens
(1) Treatment groups: externally-applied Yao medicine preparation scrub
The liniment for external use prepared in example 4 was applied to the affected part by scrubbing once.
(2) Control group: autohemotherapy
Under strict aseptic condition, a 10ml syringe is used for extracting 4m1 venous blood of a patient, the venous blood is gently shaken up, and after 2-3 min, the venous blood is rapidly injected into acupoints of both sides of the body, namely the Zusanli acupoints, and 1ml is injected into each acupoint.
4. Course of treatment
The treatment course is 3 times and 1 time, and 10 times are 30 days. Other drugs were discontinued during the treatment period.
5. Observation index
TABLE 1 active score table for chronic urticaria
From the total integral of symptoms before and after treatment for each patient, the symptom integral reduction index (SSRI) was calculated according to the following formula.
SSRI ═ (pre-treatment score-post-treatment score)/pre-treatment score.
Overall efficacy was evaluated according to SSRI: the non-cured SSRI is less than 0.60, the improved SSRI is 0.60-0.90, and the cured SSRI is more than or equal to 0.90.
6. Results
The treatment groups and the control group are treated for 30 days respectively, and the recovery, improvement and non-recovery conditions of the patients in each group are counted, and the results are shown in table 2.
TABLE 2 effective treatment of chronic urticaria by different groups
| Group of | Recovery method | Improvement of life | Not cured | Total effective rate |
| Treatment group | 20 | 4 | 2 | 92.31％ |
| Control group | 12 | 8 | 6 | 76.92％ |
As can be seen from Table 2, the external preparation provided by the invention has significant curative effect on chronic urticaria, which can reach 92.31%; the effective rate is improved by 15.39 percent compared with the autohemotherapy. Therefore, the Yao medicine external preparation obtained by Yao medicine theory compatibility has a remarkable treatment effect on chronic urticaria, can be applied by rubbing, and is simple and convenient.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (10)
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| CN104042681A (en) * | 2014-04-03 | 2014-09-17 | 赵文革 | External decoction for treating urticaria |
| CN105106464A (en) * | 2015-08-27 | 2015-12-02 | 刘新江 | Traditional Chinese medicinal preparation for treating skin diseases |
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| CN101181395A (en) * | 2007-12-13 | 2008-05-21 | 贵阳春科药业技术研发有限公司 | Medicine preparations for curing dermatosis and preparation method thereof |
| CN104042681A (en) * | 2014-04-03 | 2014-09-17 | 赵文革 | External decoction for treating urticaria |
| CN105106464A (en) * | 2015-08-27 | 2015-12-02 | 刘新江 | Traditional Chinese medicinal preparation for treating skin diseases |
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