CN108743830A - A kind of Chinese medicine composition and its preparation for treating anemopyretic cold - Google Patents
A kind of Chinese medicine composition and its preparation for treating anemopyretic cold Download PDFInfo
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Abstract
The present invention discloses a kind of Chinese medicine composition for treating anemopyretic cold, is prepared by honeysuckle flower, Fructus Forsythiae, Chinese lobelia, folium isatidis, Radix Isatidis, schizonepeta, peppermint, reed root, gypsum, Radix Glycyrrhizae；The Chinese medicine composition of the present invention is prepared by several kinds of Chinese medicinal materials, is had the effects that dispelling wind and heat from the body, clearing heat and detoxicating, dispersing swelling and dissipating binds, cool blood relieving sore-throat, purging intense heat quench the thirst, remove phlegm and relieving cough, can effectively be treated and prevented anemopyretic cold；The present invention Chinese medicine composition take into account the heart, liver, lung, spleen, kidney function protection and coordination; make drug effect and function more fully treating both manifestation and root cause of disease; it may also be fabricated which the several formulations such as capsule, granule, oral solution; it takes, is easy to carry; the sufferer for meeting the different patient's condition is taken and is carried, wide application of the crowd；In addition, the Traditional Chinese medicine composition formula of the present invention is scientific and reasonable, Small side effects are easily prepared, and crude drug source is extensive, of low cost, and good effect is convenient to take, greatly reduces financial burden and the body burden of patient, have prodigious promotional value.
Description
Technical field
The present invention relates to field of medicaments, and in particular to a kind of Chinese medicine composition and its preparation for treating anemopyretic cold.
Background technology
Flu is commonly called as catching cold, be feel ailment said due to cold or exposure or when row virus cause lung to defend the illness of functional disturbance, throughout the year
Morbidity, including a series of diseases caused by external factors symptom such as nasal obstruction, runny nose, sneeze, headache, aversion to cold, fever, general malaise, especially with Winter-Spring
Two seasons are common.Have some inkling of a cold common nasal meatus and Wei Biao symptoms, itches or uncomfortable, secondary heatable, pharyngalgia, podomere acid as pharynx nasalis is dry
Weight discomfort etc. can be in popularity, more people while sudden onset for influenza, be easy rapid sprawling.
Common cold treatment medicine in the market is generally divided into two classes, and one kind is Western medicine, though therapeutic effect is fast, toxic side effect
Big and price is high, takes body for a long time and is also easy to produce drug resistance.Chinese medicine flu is often dialectical to divide and rule, including wind-cold syndrome, wind-heat
Card, syndrome of summer-heat-dampness, syndrome of superficies cold and interior heat etc..Anemopyretic cold is caused by heresy criminal table, the lung qi of wind-heat are become estranged.Symptoms be fever weight,
Micro- foul wind, distending pain in the head, have sweat, red swelling and pain of throat, cough, phlegm glutinous or Huang, nasal obstruction with yellow thick nasal discharge, thirst and liking drink, the tip of the tongue is red, tongue is thin
Bai Weihuang.《General Treatise on the Cause and Symptoms of Diseases wind-heat is waited》：" wind-heat patient, the gas of wind-heat first enter lung from fur.Lung is the five internal organs upper cover, is waited
The fur of body, if the skin natural fibre line of meat is empty, the gas of wind-heat first hinders fur, is into lung.Its shape makes one foul wind shiver with cold, and mesh is intended to take off, tears saliva
Go out." generally common Sang Ju Yin, Radix Platycodonis decoction, supernatant dissipates and the prescriptions such as chrysanthemum powder forimproving treat anemopyretic cold, although side effect is less,
But curative effect is general, and due to how much containing some bitter different product, or since kind flavour of a drug flavoring on the high side in part is difficult, in the market
Acceptance level continuously decrease, therefore, it is necessary to develop a kind of Small side effects, good effect and Chinese medicine composition convenient to take.
The square foundation of the Chinese medicine composition composition of the application is derived from Qing Dynasty's doctor's Wu Ju Tong《Wen Bing Tiao Bian》In " Lonicera and Forsythia
It dissipates ".Present inventor Yulin City of Guangxi Zhuang Autonomous hospital of traditional Chinese hospital Huang Chunying associate chief physicians have in terms of Chinese traditional treatment common cold
Abundant clinical experience and original opinion, the application are that Huang Chunying combines personal clinical experience to obtain on the basis of " Yinqiao San "
Go out.The applicant by " Yinqiao San " for catch a cold (wind-heat syndrome) treat nearly 17 years, it is definite effect, significant in efficacy.Existing prescription is by silver
Flower, Fructus Forsythiae, Chinese lobelia, folium isatidis, Radix Isatidis, schizonepeta, peppermint, reed root, gypsum, ten taste medicinal material of Radix Glycyrrhizae form, in the application
Drug composition is the independent intellectual property right cipher prescription and non-standard preparation that applicant possesses.With dispelling wind and heat from the body, clearing heat and detoxicating
Work(, be mainly used for catch a cold (wind-heat syndrome), warm disease from the beginning for the treatment of.The Chinese medicine composition of the application was made in 2011 by applicant
Clinic trial is carried out for cipher prescription, has the clinical practice more than 7 years so far, clinical effectiveness shows that it has significant treatment wind
The effect that thermal sensation emits.
Invention content
It is an object of the invention to overcome defect of the existing technology, a kind of Chinese traditional medicine composition for treating anemopyretic cold is provided
Object and its preparation.
To achieve the goals above, the technical solution adopted by the present invention is as follows：
The Chinese medicine composition of the treatment anemopyretic cold of the present invention, is prepared by the raw material of following parts by weight：Honeysuckle flower 5-
20 parts, 7-25 parts of Fructus Forsythiae, 15-45 parts of Chinese lobelia, 5-18 parts of folium isatidis, 5-20 parts of Radix Isatidis, 5-18 parts of schizonepeta, peppermint 5-18
Part, 5-20 parts of reed root, 10-50 parts of gypsum, 3-9 parts of Radix Glycyrrhizae.
Preferably, it is prepared by the raw material of following parts by weight：12 parts of honeysuckle flower, 15 parts of Fructus Forsythiae, 30 parts of Chinese lobelia, smalt
10 parts of leaf, 12 parts of Radix Isatidis, 10 parts of schizonepeta, 10 parts of peppermint, 12 parts of reed root, 30 parts of gypsum, 6 parts of Radix Glycyrrhizae.
It is the crude drug source of Chinese medicine composition of the present invention below：
Honeysuckle flower is caprifoliaceae plant honeysuckle Lonicerajaponica Thunb., lonicera hypoglauca miq Lonicera
Hypoglauca Miq., Honeysuckle flower (hair calyx honeysuckle) Lonicera confusa DC. or hair style honeysuckle Lonicera
The dry flower of dasystyla Rehd. or with the flower just opened.It is sweet, it trembles with fear.It is clearing heat and detoxicating, wind-heat dissipating.For carbuncle swells furunculosis, larynx
Numbness, erysipelas, toxic-heat and blood stasis, anemopyretic cold, warm disease heating.
Fructus Forsythiae is the dry fruit of Oleaceae plants Fructus Forsythiae Forsythia suspensa (Thunb.) Vahl.Hardship, it is micro-
It is cold.It is clearing heat and detoxicating, dispersing swelling and dissipating binds.For ulcer, scrofula, acute mastitis, erysipelas, anemopyretic cold, warm disease is from the beginning of warm is joined the army, high fever
Polydipsia, coma macular eruption, heat gonorrhea renal shutdown.
Chinese lobelia is the drying herb of Campanulaceae Chinese lobelia Lobelia chinensis Lour..It is pungent, it puts down.Diuresis
Detumescence, it is clearing heat and detoxicating.For extensive abdominal edema, face foot edema, carbuncle swells furunculosis, snakebite and bugbite；Advanced schistosomiasis ascites.
Folium isatidis is the dried leaf of cruciferae isatis Isatis indigotica Fort..Hardship is trembled with fear.The thoughts of returning home,
Stomach.It is clearing heat and detoxicating, blood cooling and ecchymoses removing.It joins the army for warm heresy, unconsciousness due to high fever, spot dermexanthesis, jaundice, hot dysentery, mumps, larynx numbness, pellet
Poison, carbuncle swells.
Radix Isatidis is the dry root of cruciferae isatis Isatis indigotica Fort..Hardship is trembled with fear.Heat-clearing solution
Poison, cool blood relieving sore-throat.For febrile virulent maculae, tongue is dark reddish purple dark, mumps, larynx numbness, scarlet fever, major part pestilence, erysipelas, carbuncle swells.
Schizonepeta is the dry aerial parts of labiate schizonepeta SchizonepetatenuifoliaBriq..It is pungent, it is micro-
Temperature.Inducing diaphoresis relieve heat, promoting eruption.For catching a cold, have a headache, measles, rubella, sore from the beginning of.Fry charcoal treating hematochezia, uterine bleeding, postpartum anemic fainting.
Peppermint is the dry aerial parts of Labiatae mint peppermint Menthahaplocalyx Briq..It is pungent,
It is cool.Dispelling wind-heat.Refresh oneself, promoting eruption.For anemopyretic cold, wind-warm syndrome is from the beginning of, headache, hot eyes, larynx numbness, aphtha, rubella, measles,
Breast bilges frowsty.
Reed root is the fresh or dry rhizome of grass reed Phragmites communis Trin..It is sweet, it trembles with fear.
Clearing heat and promoting fluid, relieving restlessness, preventing or arresting vomiting, diuresis.For pyreticosis polydipsia, stomach hot vomiting, cough with lung heat, lung carbuncle pyemesis, puckery pain of heat gonorrhea.
Gypsum is Sulfates mineral anhydrite race gypsum, the main (CaSO containing hydrous calcium sulfate4·2H2O), after excavation, remove
Remove silt and miscellaneous stone.It is sweet, pungent, Great Cold.Clearing heat-fire, relieving restlessness are quenched the thirst.For fever caused by exogenous pathogenic factors, hyperpyrexia polydipsia, dyspnea and cough due to lung-heat, stomach fire
High Sheng is had a headache, toothache.
Radix Glycyrrhizae is glycyrrhizic legume Glycyrrhizauralensis Fisch., swollen fruit Radix Glycyrrhiza
Or the dry root of glycyrrhiza glabra Glycyrrhiza glabraL. inflataBat..Sweet and neutral.It invigorates the spleen and benefits qi, it is clearing heat and detoxicating, it dispels
Phlegm and relieving cough, relieving spasm to stop pain, coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction
Anxious pain, carbuncle sore tumefacting virus alleviate drug toxicity, strong.
It is a further object of the present invention to provide the preparation method of the active constituent of Chinese medicine composition of the present invention, this method is to adopt
It is carried with water or the extraction of the ethyl alcohol of 40-70% concentration expressed in percentage by volumes is prepared.Specific preparation method is as follows：
Scheme one：Whole medicinal materials are taken, extracting in water 2-3 times after mixing, each amount of water is equivalent to the 6- of medicinal material total weight
12 times, each extraction time is 1-3 hours, merges extracting solution, filtering, relative density is 1.10- when filtrate concentrates 70-80 DEG C
1.20 clear cream is to get active constituent.
Scheme two：Whole medicinal materials are taken, are extracted 2-3 times with 40-70% alcohol refluxs after mixing, each ethanol consumption is medicinal material
4-10 times of total weight, extraction time are 1-4 hours, merge extracting solution, filtering, relative density when filtrate is concentrated into 70-80 DEG C
For 1.05-1.20 clear cream to get active constituent.
Scheme three：Whole medicinal materials are taken, extracting in water 2-3 times after mixing, each amount of water is equivalent to the 6- of medicinal material total weight
12 times, each extraction time is 1-3 hours, merges extracting solution, filtering, relative density is 1.10- when filtrate is concentrated into 70-80 DEG C
Ethyl alcohol is added in 1.20 clear cream, and it is 40-70% to make alcohol content, stands 12-24 hours, filtering, when filtrate is concentrated into 70-80 DEG C
Relative density is the medicinal extract of 1.05-1.20 to get active constituent.
The Chinese medicine composition for the treatment of anemopyretic cold of the present invention, can also match with pharmaceutically acceptable carrier
It closes, various preparations, such as tablet, capsule, oral solution, syrup, mixture, granule is made.
The pharmaceutically acceptable carrier of the present invention includes but not limited to following：
Diluent：Starch, Icing Sugar, lactose, dextrin, microcrystalline cellulose, inorganic salts, glycitols etc..
Wetting agent and adhesive：Purified water, ethyl alcohol, gelatin, polyethylene glycol, cellulose derivative etc..
Disintegrant：Starch, sodium carboxymethyl starch, cellulose derivative, crospovidone etc..
Lubricant：Magnesium stearate, superfine silica gel powder, talcum powder, polyethylene glycol etc..
Cosolvent：Water, ethyl alcohol, glycerine, propylene glycol, liquid paraffin, vegetable oil etc..
Corrigent：Sucrose, monosaccharide, aromatic etc..
Preservative：Benzoic acid, sorbic acid, methyl esters, ethyl ester, propyl ester etc..
Method 1：Tablet
It takes scheme one one of to three gained active constituent of scheme, tablet is added and often uses auxiliary material, routinely prepared by production method
Obtain Tablets.
Above-mentioned tablet often includes one of diluent, wetting agent, adhesive, disintegrant, lubricant or whole with auxiliary material.
Method 2：Capsule
It takes scheme one one of to three gained active constituent of scheme, capsule is added and often uses auxiliary material, routinely producer legal system
It is standby to obtain capsule of the present invention.
Above-mentioned capsule often includes one of diluent, wetting agent, adhesive, disintegrant, lubricant or whole with auxiliary material.
Method 3：Syrup
It takes scheme one one of to three gained active constituent of scheme, syrup is added and often uses auxiliary material, routinely producer legal system
It is standby to obtain syrup of the present invention.
Above-mentioned syrup often includes one of corrigent, preservative, cosolvent or whole with auxiliary material.
Method 4：Mixture
It takes scheme one one of to three gained active constituent of scheme, mixture is added and often uses auxiliary material, routinely prepared by production method
Obtain mixture of the present invention.
Above-mentioned mixture often includes one of corrigent, preservative or whole with auxiliary material.
Method 5：Oral solution
Take scheme one one of to three gained active constituent of scheme, dissolving after-purification, concentration are added oral solution and often use auxiliary material,
Routinely production method is prepared into oral solution of the present invention.
Above-mentioned oral solution often includes one of corrigent, preservative, cosolvent or whole with auxiliary material.
Method 6：Granule
It takes scheme one one of to three gained active constituent of scheme, granule is added and often uses auxiliary material, routinely producer legal system
It is standby to obtain granule of the present invention.
Above-mentioned granule often includes one of diluent, wetting agent, adhesive, disintegrant, lubricant or whole with auxiliary material.
The applicant combines Traditional Chinese Medicine Coryza Treated by Syndrome Differentiation and modern pharmacological research achievement, in abundant clinical experience and original
On the basis of opinion, compare multiple formulations, obtains and stop with dispelling wind and heat from the body, clearing heat and detoxicating, dispersing swelling and dissipating binds, cool blood relieving sore-throat, purging intense heat
Yearningly, the Chinese medicine composition for the effects that removing phlegm and relieving cough.The Chinese medicine composition of the present invention is using honeysuckle flower, Fructus Forsythiae as monarch drug in a prescription, honeysuckle flower heat-clearing solution
Poison, wind-heat dissipating, Fructus Forsythiae while clearing heat and detoxicating can also dispersing swelling and dissipating binds, Papillary expelling wind to resolve the exterior, reconcile lung qi；Schizonepeta,
Peppermint, Chinese lobelia, folium isatidis, Radix Isatidis are ministerial drug, schizonepeta and peppermint inducing diaphoresis relieve heat, diathermanous outgoing, schizonepeta slightly warm in nature, temperature without
Dry, with honeysuckle flower, Fructus Forsythiae compatibility, warm nature is made, enhance we pungent scattered inducing diaphoresis the effect of；Chinese lobelia, folium isatidis and Radix Isatidis are clear
Thermal detoxification, inducing diuresis to remove edema, reinforce monarch drug in a prescription it is clearing heat and detoxicating the effect of；Reed root sweet and cool-natured is gently clear, and clearing heat and promoting fluid is so quench the thirst, gypsum
It is sweet, pungent, it trembles with fear, lets out the heat of lung stomach clearly to promote the production of body fluid, therefore reed root is adjutant altogether with gypsum, assistant principal drug assistance and ministerial drug is clearing heat and detoxicating, promotes the production of body fluid
Quench the thirst；Radix Glycyrrhizae coordinating the drug actions of a prescription, with to make medicine.Full side is compatible with clearing heat and detoxicating drug and pungent scattered table heresy drug, altogether long memorial relieve heat
Hot, clearing heat and detoxicating, dispersing swelling and dissipating binds, cool blood relieving sore-throat, purging intense heat quench the thirst, go the effect of phlegm and relieving cough, for anemopyretic cold, warm disease from the beginning of having
Good therapeutic effect.
The present invention is by adopting the above-described technical solution, have the advantages that：
(1) Chinese medicine composition and its preparation of the invention are prepared by several kinds of Chinese medicinal materials, and safety is mild, are made to human body pair
With minimum, have the effects that dispelling wind and heat from the body, clearing heat and detoxicating, dispersing swelling and dissipating binds, cool blood relieving sore-throat, purging intense heat quench the thirst, go phlegm and relieving cough, honeysuckle flower clear
Thermal detoxification, wind-heat dissipating, Fructus Forsythiae while clearing heat and detoxicating can also dispersing swelling and dissipating binds, Papillary fundamentally treats wind-heat；Chaste tree
Mustard and peppermint inducing diaphoresis relieve heat, it is diathermanous outgoing；Chinese lobelia, folium isatidis and Radix Isatidis is clearing heat and detoxicating, inducing diuresis to remove edema, reinforce honeysuckle flower and company
The antipyretic and antidote functions stuck up；Reed root and gypsum heat-clearing promote the production of body fluid to quench thirst, and reduce pharyngeal scorching, alleviate abscess of throat；The mild-natured taste of Radix Glycyrrhizae
Sweet, coordinating the drug actions of a prescription, the different product of hardship in neutralization side play certain flavored action, altogether long memorial dissipate wind-heat, clearing heat and detoxicating, detumescence
Dissipating bind, cool blood relieving sore-throat, purging intense heat are quenched the thirst, are gone the effect of phlegm and relieving cough, and anemopyretic cold is effectively treated and prevented.Chinese medicine composition of the present invention
And its preparation take into account the heart, liver, lung, spleen, kidney function protection and coordination, fully demonstrated traditional Chinese medicine organic conception and advantage,
Make drug effect and function more fully treating both manifestation and root cause of disease.
(2) Chinese medicine composition of the invention and its preparation clinical tests prove that, Chinese medicine composition of the invention and its system
Agent is 72.25% to the cure rate of anemopyretic cold, total effective rate 96.50%.It can be seen that Chinese medicine composition of the present invention and its preparation
There is preferable clinical efficacy to anemopyretic cold.Show that patient generally can feel wind-heat sense after the 3d that takes medicine by clinical observation
It emits related symptoms to have clear improvement, related symptoms disappear substantially after taking 5d, and related symptoms disappear after taking a course for the treatment of, curative effect
Rapid significantly and to be had no abnormal changes to the Liver and kidney function and hemopoietic system of patient and adverse reaction, the state of an illness does not go out after drug withdrawal
Existing " rebound ", clinic are taken securely and reliably.
(3) several formulations are made in Chinese medicine composition of the invention, take, is easy to carry, meet the sufferer clothes of the different patient's condition
With and carry, wide application of the crowd.
(4) Chinese medicine composition and its pharmaceutical formulation of the invention are scientific and reasonable, and Small side effects, preparation method is simple, prepare
It is at low cost, body and the financial burden of patient can be mitigated significantly, there is prodigious promotional value.
Specific implementation mode
To make the objectives, technical solutions, and advantages of the present invention more comprehensible, preferred embodiment is enumerated below, to this hair
Bright further description.However, it is necessary to illustrate, many details listed in specification are used for the purpose of making reader to this
There are one thorough explanations for the one or more aspects of invention, can also realize the present invention's even without these specific details
These aspects.Unless otherwise indicated, the percentage of the amount of alcohol in the present invention is percentage by volume, and v/v indicates the volume of solution
Than.
1 tablet of embodiment
Weigh honeysuckle flower 5kg, Fructus Forsythiae 7kg, Chinese lobelia 15kg, folium isatidis 5kg, Radix Isatidis 5kg, schizonepeta 5kg, peppermint 5kg, reed
Root 5kg, gypsum 10kg, Radix Glycyrrhizae 3kg；
Whole medicinal materials are taken, extracting in water 2 times after mixing, each amount of water is equivalent to 12 times of medicinal material total weight, 10 times, and two
Secondary extraction time is respectively 3 hours, 2 hours, merge extracting solution, filtering, filtrate concentrate 70 DEG C when relative density be 1.10 it is clear
Additive of tablet microcrystalline cellulose, gelatin, magnesium stearate, polyethylene glycol is added in cream in clear cream, and routinely tablet is made in scheme.
2 tablet of embodiment
Weigh honeysuckle flower 7kg, Fructus Forsythiae 9kg, Chinese lobelia 19kg, folium isatidis 7kg, Radix Isatidis 7kg, schizonepeta 6kg, peppermint 7kg, reed
Root 6kg, gypsum 15kg, Radix Glycyrrhizae 4kg；
Whole medicinal materials are taken, are extracted 3 times with 40% alcohol reflux after mixing, each ethanol consumption is the 10 of medicinal material total weight
Again, 8 times, 6 times, extraction time is respectively 4 hours, 2 hours, 1 hour three times, merges extracting solution, filtering, and filtrate is concentrated into 70 DEG C
When relative density be 1.05 clear cream, additive of tablet dextrin, polyethylene glycol, starch, magnesium stearate is added, routinely scheme is made
Tablet.
3 capsule of embodiment
Weigh honeysuckle flower 9kg, Fructus Forsythiae 11kg, Chinese lobelia 23kg, folium isatidis 8kg, Radix Isatidis 9kg, schizonepeta 8kg, peppermint 8kg,
Reed root 7kg, gypsum 20kg, Radix Glycyrrhizae 5kg；
Whole medicinal materials are taken, extracting in water 2 times after mixing, each amount of water is equivalent to 12 times of medicinal material total weight, 8 times, often
Secondary extraction time is respectively 3 hours, 2 hours, merges extracting solution, filtering, relative density is 1.10 when filtrate is concentrated into 70 DEG C
Ethyl alcohol is added in clear cream, and it is 40% to make alcohol content, stands 12 hours, filtering, and relative density is 1.05 when filtrate is concentrated into 70 DEG C
Capsule auxiliary material Icing Sugar, cellulose derivative, crospovidone, ethyl alcohol is added in medicinal extract in medicinal extract, and routinely glue is made in scheme
Wafer.
4 capsule of embodiment
Weigh honeysuckle flower 10kg, Fructus Forsythiae 13kg, Chinese lobelia 27kg, folium isatidis 9kg, Radix Isatidis 10kg, schizonepeta 9kg, peppermint
9kg, reed root 10kg, gypsum 25kg, Radix Glycyrrhizae 6kg；
Take whole medicinal materials, extracting in water 3 times after mixing, each amount of water be equivalent to 10 times of medicinal material total weight, 8 times, 6
Times, each extraction time is respectively 3 hours, 2 hours, 1 hour, merges extracting solution, filtering, relative density when filtrate concentrates 75 DEG C
For 1.14 clear cream, capsule auxiliary material dextrin, polyethylene glycol, superfine silica gel powder, lactose are added in clear cream, routinely scheme is made
Capsule.
5 syrup of embodiment
Weigh honeysuckle flower 20kg, Fructus Forsythiae 25kg, Chinese lobelia 45kg, folium isatidis 18kg, Radix Isatidis 20kg, schizonepeta 18kg, peppermint
18kg, reed root 20kg, gypsum 50kg, Radix Glycyrrhizae 9kg；
Whole medicinal materials are taken, are extracted 3 times with 57% alcohol reflux after mixing, each ethanol consumption is 8 times of medicinal material total weight,
6 times, 4 times, each extraction time is respectively 3 hours, 2 hours, 1 hour, merges extracting solution, filtering, when filtrate is concentrated into 77 DEG C
Syrup auxiliary material monosaccharide, sorbic acid and water are added in clear cream, stirs evenly for the clear cream that relative density is 1.06, and syrup is made
Agent.
6 mixture of embodiment
Weigh honeysuckle flower 14kg, Fructus Forsythiae 18kg, Chinese lobelia 34kg, folium isatidis 12kg, Radix Isatidis 14kg, schizonepeta 12kg, peppermint
12kg, reed root 14kg, gypsum 35kg, Radix Glycyrrhizae 7kg；
Take whole medicinal materials, extracting in water 3 times after mixing, each amount of water be equivalent to 10 times of medicinal material total weight, 7 times, 6
Times, each extraction time is respectively 3 hours, 1 hour, 1 hour, merges extracting solution, filtering, filtrate is concentrated into relatively close at 75 DEG C
Degree is 1.16 clear cream, and ethyl alcohol is added, and it is 60% to make alcohol content, stands 19 hours, and filtering, filtrate is concentrated into relatively close at 74 DEG C
Degree is 1.10 medicinal extract, and mixture auxiliary material sucrose and benzoic acid are added in medicinal extract, stirs evenly, and mixture is made.
7 oral solution of embodiment
Weigh honeysuckle flower 16kg, Fructus Forsythiae 21kg, Chinese lobelia 38kg, folium isatidis 14kg, Radix Isatidis 16kg, schizonepeta 14kg, peppermint
14kg, reed root 16kg, gypsum 40kg, Radix Glycyrrhizae 8kg；
Take whole medicinal materials, extracting in water 3 times after mixing, each amount of water be equivalent to 10 times of medicinal material total weight, 8 times, 6
Times, each extraction time is respectively 3 hours, 2 hours, 1 hour, merges extracting solution, filtering, relative density when filtrate concentrates 80 DEG C
For 1.20 clear cream, oral solution auxiliary material sorbic acid, monosaccharide and water are added in clear cream, oral solution is made in packing.
8 granule of embodiment
Weigh honeysuckle flower 18kg, Fructus Forsythiae 23kg, Chinese lobelia 42kg, folium isatidis 16kg, Radix Isatidis 18kg, schizonepeta 16kg, peppermint
16kg, reed root 18kg, gypsum 45kg, Radix Glycyrrhizae 9kg；
Whole medicinal materials are taken, are extracted 2 times with 70% alcohol reflux after mixing, each ethanol consumption is 6 times of medicinal material total weight,
4 times, extraction time is respectively 2 hours, 1 hour, merges extracting solution, filtering, relative density is 1.20 when filtrate is concentrated into 80 DEG C
Clear cream, supplementary product starch, ethyl alcohol, cellulose derivative, microcrystalline cellulose are added in clear cream, granulation, dry, whole grain are made
Granule.
9 granule of embodiment
Weigh honeysuckle flower 12kg, Fructus Forsythiae 15kg, Chinese lobelia 30kg, folium isatidis 10kg, Radix Isatidis 12kg, schizonepeta 10kg, peppermint
10kg, reed root 12kg, gypsum 30kg, Radix Glycyrrhizae 6kg；
Whole medicinal materials are taken, extracting in water 2 times after mixing, each amount of water is equivalent to 12 times of medicinal material total weight, 6 times, often
Secondary extraction time is 3 hours, 2 hours, merges extracting solution, is filtered, the clear cream that relative density is 1.20 when filtrate is concentrated into 80 DEG C,
Ethyl alcohol is added, it is 70% to make alcohol content, stands 24 hours, filtering, the medicinal extract that relative density is 1.20 when filtrate is concentrated into 80 DEG C,
Auxiliary material dextrin, water, polyethylene glycol, crospovidone, talcum powder are added in medicinal extract, granule is made in granulation, dry, whole grain.
Clinical test is summarized
1, basic document
Select the part anemopyretic cold patient totally 400 that the applicant accepts for medical treatment so far in 2011, wherein male patient 183
Example, female patient 217.Age 16-70 Sui, course of disease 0.5-3 months.There was no significant difference in terms of the state of an illness by patient, and having can
Compare property.Exclude gestation and women breast-feeding their children, those who are allergic to this drug, severe cardiac pulmonary dysfunction, non-coronary disease characteristic of disease heart disease, kidney
Disease, hypertension, stomach patient.
2, diagnostic criteria
Disease is shown in that the micro- foul wind of fever, sweat let out unsmooth, distending pain in the head, coughs, and phlegm is glutinous or yellow, dry, the abscess of throat of pharynx, nasal obstruction, and stream is yellow
Turbid tears, thirst with desire to drink, tongue side point is red, thin lingual fur or micro- Huang, superficial and rapid pulse person.
3, therapy
It is given and is treated using the granule of the embodiment of the present invention 9,3 times a day, each 10g, 7 days as a course for the treatment of.One
Optionally additional treatment after the course for the treatment of, requires the drug for not having to this disease of other treatment during observation.
4, curative effect judging standard
It cures：Anemopyretic cold related symptoms disappear, and sign and laboratory examination are without exception.
It is effective：Anemopyretic cold related symptoms, sign and laboratory examination have clear improvement.
Effectively：Anemopyretic cold related symptoms, sign and laboratory examination have improvement.
In vain：Anemopyretic cold related symptoms, sign and laboratory examination are without improvement.
5, result
Clinical efficacy is shown in Table 1.
1 therapeutic effect of table
| Illness | Healing/example | Significantly/example | Effectively/example | In vain/example | Cure rate/% | Total effective rate/% |
| Anemopyretic cold | 289 | 63 | 34 | 14 | 72.25 | 96.50 |
As it can be seen from table 1 the treatment by a course for the treatment of, Chinese medicine composition of the invention and its preparation are to anemopyretic cold
Cure rate be 72.25%, total effective rate 96.50%.It can be seen that Chinese medicine composition of the present invention and its preparation have anemopyretic cold
Preferable clinical efficacy.Show that patient generally can feel that anemopyretic cold related symptoms have after the 3d that takes medicine by clinical observation
It being obviously improved, related symptoms disappear substantially after taking 5d, and related symptoms disappear after taking a course for the treatment of, and curative effect is notable rapidly, and
The Liver and kidney function and hemopoietic system of patient are had no abnormal changes and adverse reaction, " rebounding " does not occur in the state of an illness after drug withdrawal, faces
Bed is taken safe and reliable.
Model case
Case 1：Zheng XX, man, 27 years old.
Main suit：Occurred the symptoms such as fever, nasal obstruction, runny nose, cough, pharyngalgia before three days, does not draw attention and do not treated, disease
Shape is seen a doctor then to clinic without substantially reduced, and symptom is improved after giving infusion treatment, is admitted to hospital symptoms include the micro- foul wind of heat, distending pain in the head, cough
It coughs, cough yellow sticks phlegm, abscess of throat, and nasal obstruction flows turbid nasal discharge, thirst with desire to drink.Physical examination pharyngeal portion flare, tonsillotome I0Enlargement, tongue side
Point is red, and thin lingual fur is yellow, superficial and rapid pulse.Laboratory examination leucocyte 9.3 × 109/ L, neutrophil leucocyte 0.83%.It takes of the invention real
I.e. only, neutrophil leucocyte index is restored to normal range (NR) for fever after applying the tablet 3d of example 1, and upper all diseases mitigate, and continue after taking 4d
No foul wind headache, pharyngalgia, runny nose etc., occasionally there is cough, and without apparent expectoration, pink tongue tongue is thin white, and arteries and veins is slow.
Case 2：Zhao X, female, 36 years old.
Main suit：Occurred fever, cough before 2 days, outer court's intravenous infusion Ceftazidime for treatment, cough is improved, but still is sent out repeatedly
Heat, 39.3 DEG C of body temperature symptoms include fever and aversion to wind, when have a cough, faint yellow phlegm, nasal obstruction aggravate cough to the wind on a small quantity, flow the turbid tears of yellow,
Abscess of throat, thirst with desire to drink, tongue is red, and thin lingual fur is yellow, superficial and rapid pulse.Fever i.e. only, takes after taking 3 capsule 1d of the embodiment of the present invention
Mitigated with all diseases after 5d, continues to take 8d totally two courses for the treatment of, all symptoms disappear, is diagnosed as healing.
Case 3：Wu X, man, 48 years old.
Main suit：There is fever, cough before 1 week because blowing air-conditioning and suffering from cold in patient, and had viscous phlegm, and general fatigue is powerless, anorexia,
It is treated without improvement using medicines such as Cefradine, swap buffers, is still generated heat repeatedly, with cough, cough yellow mucus sample Huang phlegm, nasal obstruction stream is turbid
Tears, pharyngalgia dry throat, dry desire for cold-drinking drink, spiritlessness and weakness, food intake is not good enough；Physical examination：39.0 DEG C of body temperature, apathetic, pharyngeal portion flare,
Tongue side, red tip of tongue, thin lingual fur is yellow, superficial and rapid pulse, takes the oral solution 4d of the embodiment of the present invention 7, and fever only, continues to take 3d,
All symptoms disappear, is diagnosed as healing.
Claims (7)
1. a kind of Chinese medicine composition for treating anemopyretic cold, which is characterized in that be prepared by the raw material of following parts by weight：Silver
5-20 parts of flower, 7-25 parts of Fructus Forsythiae, 15-45 parts of Chinese lobelia, 5-18 parts of folium isatidis, 5-20 parts of Radix Isatidis, 5-18 parts of schizonepeta, peppermint 5-
18 parts, 5-20 parts of reed root, 10-50 parts of gypsum, 3-9 parts of Radix Glycyrrhizae.
2. the Chinese medicine composition for the treatment of anemopyretic cold according to claim 1, which is characterized in that by the original of following parts by weight
What material was prepared：12 parts of honeysuckle flower, 15 parts of Fructus Forsythiae, 30 parts of Chinese lobelia, 10 parts of folium isatidis, 12 parts of Radix Isatidis, 10 parts of schizonepeta, peppermint
10 parts, 12 parts of reed root, 30 parts of gypsum, 6 parts of Radix Glycyrrhizae.
3. the Chinese medicine composition for the treatment of anemopyretic cold according to claim 1 or 2, it is characterised in that：Its active constituent
Be carried using water or the ethyl alcohol of 40-70% concentration expressed in percentage by volumes extraction be prepared.
4. the Chinese medicine composition for the treatment of anemopyretic cold according to claim 3, which is characterized in that its active constituent is logical
Cross what following methods were prepared：Whole medicinal materials are taken, extracting in water 2-3 times after mixing, each amount of water is equivalent to medicinal material gross weight
6-12 times of amount, each extraction time are 1-3 hours, merge extracting solution, filtering, relative density when filtrate is concentrated into 70-80 DEG C
For 1.10-1.20 clear cream to get active constituent.
5. the Chinese medicine composition for the treatment of anemopyretic cold according to claim 3, which is characterized in that its active constituent is logical
Cross what following methods were prepared：Whole medicinal materials are taken, are extracted 2-3 times with 40-70% alcohol refluxs after mixing, each ethanol consumption
It it is 4-10 times of medicinal material total weight, extraction time is 1-4 hours, merges extracting solution, filtering, and filtrate is concentrated into 70-80 DEG C of phase
To density be 1.05-1.20 clear cream to get active constituent.
6. the Chinese medicine composition for the treatment of anemopyretic cold according to claim 3, which is characterized in that its active constituent is logical
Cross what following methods were prepared：Whole medicinal materials are taken, extracting in water 2-3 times after mixing, each amount of water is equivalent to medicinal material gross weight
6-12 times of amount, each extraction time are 1-3 hours, merge extracting solution, filtering, relative density when filtrate is concentrated into 70-80 DEG C
For the clear cream of 1.10-1.20, ethyl alcohol is added, it is 40-70% to make alcohol content, stands 12-24 hours, and filtering, filtrate is concentrated into 70-
Relative density is the medicinal extract of 1.05-1.20 to get active constituent at 80 DEG C.
7. a kind of Chinese medicine preparation for treating anemopyretic cold treats anemopyretic cold by claims 1 or 2 or 4-6 any one of them
Chinese medicine composition be prepared with pharmaceutically acceptable carrier combination.
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| CN108310199A (en) * | 2018-02-26 | 2018-07-24 | 广西中医药大学第附属医院 | A kind of Chinese medicine composition and its preparation for treating coronary disease and angina pectoris |
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| CN108310199A (en) * | 2018-02-26 | 2018-07-24 | 广西中医药大学第附属医院 | A kind of Chinese medicine composition and its preparation for treating coronary disease and angina pectoris |
Non-Patent Citations (4)
| Title |
|---|
| 易磊等: "《中国秘方大全》", 31 May 2013, 上海科学技术文献出版社 * |
| 王学文: "《贵州苗药 兴仁卷》", 31 October 2014, 贵州民族出版社 * |
| 赵玉玲: "《民间土单验方治百病：药到病除》", 31 May 2004, 中国建材工业出版社 * |
| 陈仁涛: "《江苏中医当代名家学术思想与临床经验：全2册》", 31 January 2016, 上海科学技术出版社 * |
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