CN108743628A - 茯苓鲜提冷冻干燥粉末饮片 - Google Patents
茯苓鲜提冷冻干燥粉末饮片 Download PDFInfo
- Publication number
- CN108743628A CN108743628A CN201810733207.8A CN201810733207A CN108743628A CN 108743628 A CN108743628 A CN 108743628A CN 201810733207 A CN201810733207 A CN 201810733207A CN 108743628 A CN108743628 A CN 108743628A
- Authority
- CN
- China
- Prior art keywords
- poria cocos
- fresh
- decoction
- materical crude
- medicine materical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000003814 drug Substances 0.000 title claims abstract description 22
- 235000008599 Poria cocos Nutrition 0.000 title claims abstract description 21
- 241001619444 Wolfiporia cocos Species 0.000 title claims abstract description 21
- 239000000843 powder Substances 0.000 title claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000006071 cream Substances 0.000 claims abstract description 7
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims abstract description 7
- 239000002775 capsule Substances 0.000 claims abstract description 3
- 239000006187 pill Substances 0.000 claims abstract description 3
- 238000003306 harvesting Methods 0.000 claims abstract 2
- 239000003826 tablet Substances 0.000 claims abstract 2
- 239000000463 material Substances 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 3
- 239000012535 impurity Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 2
- 239000008399 tap water Substances 0.000 claims description 2
- 235000020679 tap water Nutrition 0.000 claims description 2
- 238000009777 vacuum freeze-drying Methods 0.000 claims description 2
- -1 clean in time Substances 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 238000003860 storage Methods 0.000 description 3
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 230000035900 sweating Effects 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 208000030090 Acute Disease Diseases 0.000 description 1
- 241000282461 Canis lupus Species 0.000 description 1
- 241000737241 Cocos Species 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010030302 Oliguria Diseases 0.000 description 1
- 241001619461 Poria <basidiomycete fungus> Species 0.000 description 1
- 241000576755 Sclerotia Species 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 238000009412 basement excavation Methods 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000002893 slag Substances 0.000 description 1
- 238000009461 vacuum packaging Methods 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Public Health (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
本发明公布了一种“茯苓鲜提冷冻干燥粉末饮片”，其主要特征在于：在茯苓采收后，趁鲜洗涤、切片、榨汁、提取，提取液浓缩成清膏后冷冻干燥，再经粉碎、过筛后真空包装。粉末饮片的含水量少于10%。本饮片质量稳定，既可以入汤剂煎煮，也可以直接入丸剂、散剂、片剂、胶囊剂，利于携带，临床使用方便。
Description
技术领域
本发明属于中药饮片技术领域，尤其属于茯苓饮片的加工领域。
背景技术
中药茯苓为多孔菌科真菌茯苓 Poria cocos（Schw.）Wolf 的干燥菌核，具有利水渗湿，健脾，宁心的功效。本品主要用于水肿尿少，痰饮眩悸，脾虚食少，便溏泄泻，心神不安，惊悸失眠等的治疗，是中医临床上常见的一味中药。传统茯苓的加工方法为：采挖后除去泥沙，堆置“发汗”后，摊开晾至表面干燥，再“发汗”，反复数次至现皱纹、内部水分大部散失后，阴干，称为“茯苓个”；或将鲜茯苓按不同部位切制，阴干，分别称为“茯苓块”和“茯苓片”，打包，储运。“茯苓个”到饮片厂后，再洗涤、润软、切片、干燥、包装。此类饮片体积大，卫生学标准差，易于受潮、长霉、生虫，不利于保管，储存和运输成本高。此外，这样的饮片质量稳定性差，临床疗效难以保障，病人服用不方便，起效慢。因此，开发一种质量稳定可靠、储存/运输成本低、利于保管、携带和使用方便、起效快的新型茯苓饮片，势在必行。目前市场茯苓饮片，除了传统饮片之外，还有超微粉饮片和浓缩颗粒饮片两种形式，但两者都是以传统饮片为原料，其质量决定于传统饮片的质量，且超微饮片不能解决药材污染的问题；浓缩颗粒只能提取出水溶性成分。
发明内容
本发明公布了一种“茯苓鲜提冷冻干燥粉末饮片”，其主要特征在于：在茯苓采收后，及时净选，去除泥沙等杂质和非药用部位，于24小时内趁鲜用自来水洗净并切成2~5mm厚的片。将此切好的片加入1~5倍重量50~70℃的水中，浸泡并时时搅拌5~30分钟，过滤，药渣压榨取汁。所得药渣中再加入5~10倍重量的水，煮沸10~30分钟，趁热过滤，药渣再次榨汁，收集药汁。合并上述药汁，过60~100目筛，减压浓缩，温度为50~75℃，浓缩至相对密度为1.15~1.25的清膏。将所得清膏在-20~-80℃冰箱中冻结12~24小时后，在-20~-40℃真空冷冻干燥。冻干物再在60~80℃真空干燥至含水量低于10%，粉碎，过60目筛，真空包装，即得成品。本饮片临床一般使用量为1~5g，既可入汤剂煎服、冲服，也可直接入丸剂、散剂、胶囊剂及片剂中，从而大大提高了临床使用的便捷性和顺应性，有利于临床急症的治疗。
本发明解决了传统茯苓饮片体积庞大、储运成本高、不利于保管、易生霉生虫、卫生学条件差、质量不稳定等诸多缺点，由于是趁鲜提取，质量比超微粉碎饮片和浓缩颗粒饮片更好。
具体实施例
将茯苓药材采收后，净选，除去泥沙等杂质和非药用部位，在6小时内趁鲜用自来水洗净，并切成3mm厚的片。将此片加入5倍重量的70℃的纯净水，搅拌30分钟，过滤，药渣压榨取汁。 再往上述药渣中再加入8倍重量的纯净水，煮沸20分钟提取，趁热过滤，药渣再次榨汁，收集药汁。合并上述药汁，减压浓缩，温度为设定为70℃，浓缩至相对密度为1.20的清膏。将所得的清膏于-80℃冻结12小时后，在-40℃真空冷冻干燥。干燥物再用60℃真空干燥至含水量为8%，粉碎，过60目筛，真空包装，即得成品。
Claims (2)
1.一种茯苓鲜提冷冻干燥粉末饮片，其主要特征在于：在茯苓药材采收后，及时净选，去除泥沙等杂质和非药用部位，保持药材表面湿润，于24小时内趁鲜用自来水洗净并切成2~5mm厚的片，加入1~5倍重量50~70℃的水，浸泡并时时搅拌5~30分钟，过滤，药渣压榨取汁；所得药渣中再加入5~10倍重量的水，煮沸10~30分钟，趁热过滤，药渣再次榨汁，收集药汁；合并上述药汁，过60~100目筛，减压浓缩，温度为50~75℃，浓缩至相对密度为1.15~1.25的清膏；所得清膏在-20~-80℃冰箱中冻结12~24小时后，在-20~-40℃真空冷冻干燥；冻干物再在60~80℃真空干燥至含水量低于12%，粉碎，过60目筛，真空包装，即得成品。
2.根据权利要求1所述的茯苓鲜提冷冻干燥粉末饮片，其主要特征在于：临床一般使用量为1~5g，既可入汤剂煎服、冲服，也可直接入丸剂、散剂、胶囊剂及片剂中。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810733207.8A CN108743628A (zh) | 2018-07-06 | 2018-07-06 | 茯苓鲜提冷冻干燥粉末饮片 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810733207.8A CN108743628A (zh) | 2018-07-06 | 2018-07-06 | 茯苓鲜提冷冻干燥粉末饮片 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108743628A true CN108743628A (zh) | 2018-11-06 |
Family
ID=63972381
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810733207.8A Withdrawn CN108743628A (zh) | 2018-07-06 | 2018-07-06 | 茯苓鲜提冷冻干燥粉末饮片 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108743628A (zh) |
-
2018
- 2018-07-06 CN CN201810733207.8A patent/CN108743628A/zh not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108524787A (zh) | 天麻鲜提冷冻干燥粉末饮片 | |
| CN108524562A (zh) | 羌活鲜提冷冻干燥粉末饮片 | |
| CN108671036A (zh) | 白芍鲜提冷冻干燥粉末饮片 | |
| CN108771688A (zh) | 茯苓鲜提喷雾干燥粉末饮片 | |
| CN108671008A (zh) | 太子参鲜提冷冻干燥粉末饮片 | |
| CN108553519A (zh) | 白芍鲜提冷冻干燥颗粒饮片 | |
| CN108671006A (zh) | 党参鲜提真空干燥粉末饮片 | |
| CN108553491A (zh) | 白芷鲜提冷冻干燥粉末饮片 | |
| CN108743628A (zh) | 茯苓鲜提冷冻干燥粉末饮片 | |
| CN108619305A (zh) | 地黄鲜提冷冻干燥颗粒饮片 | |
| CN108578453A (zh) | 川芎鲜提冷冻干燥粉末饮片 | |
| CN108542925A (zh) | 茯苓鲜提真空干燥粉末饮片 | |
| CN108671005A (zh) | 党参鲜提冷冻干燥粉末饮片 | |
| CN108524558A (zh) | 牛膝鲜提冷冻干燥粉末饮片 | |
| CN108619222A (zh) | 黄芪鲜提冷冻干燥粉末饮片 | |
| CN108671016A (zh) | 甘草鲜提冷冻干燥粉末饮片 | |
| CN108619205A (zh) | 白术鲜提冷冻干燥粉末饮片 | |
| CN108635403A (zh) | 甘草鲜提冷冻干燥颗粒饮片 | |
| CN108635385A (zh) | 当归鲜提冷冻干燥粉末饮片 | |
| CN108524582A (zh) | 桔梗鲜提冷冻干燥粉末饮片 | |
| CN108524604A (zh) | 黄芩鲜提冷冻干燥粉末饮片 | |
| CN108635534A (zh) | 百部鲜提冷冻干燥粉末饮片 | |
| CN108498567A (zh) | 黄芪鲜提冷冻干燥颗粒饮片 | |
| CN108619230A (zh) | 丹参鲜提冷冻干燥粉末饮片 | |
| CN108721366A (zh) | 天花粉鲜提冷冻干燥粉末饮片 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20181106 |