CN108735304A - A kind of Chinese medicine compound prescription information retrieval system - Google Patents

A kind of Chinese medicine compound prescription information retrieval system Download PDF

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Publication number
CN108735304A
CN108735304A CN201810333542.9A CN201810333542A CN108735304A CN 108735304 A CN108735304 A CN 108735304A CN 201810333542 A CN201810333542 A CN 201810333542A CN 108735304 A CN108735304 A CN 108735304A
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effect
pharmacological property
compound
module
chinese medicine
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黄海阳
陈冠林
许仕杰
黄纯美
李耿
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Dongguan Institute of Traditional Chinese Medicine Engineering Guangzhou Univers
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Dongguan Institute of Traditional Chinese Medicine Engineering Guangzhou Univers
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    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H70/00ICT specially adapted for the handling or processing of medical references
    • G16H70/40ICT specially adapted for the handling or processing of medical references relating to drugs, e.g. their side effects or intended usage

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  • Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Medical Treatment And Welfare Office Work (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention relates to Chinese Traditional Medicine informations to inquire applied technical field, refer in particular to a kind of Chinese medicine compound prescription information retrieval system, including data input module, data retrieval module and data disaply moudle, the data input module is connect with data retrieval module, the data retrieval module is connect with data disaply moudle, and the data retrieval module includes that database, pharmacological property content functional analysis module, pharmacological property Compatibility Law functional analysis module and pharmacological property compatibility express effect functional analysis module;A kind of Chinese medicine compound prescription information retrieval system provided by the invention, it can intuitively indicate the information of Chinese medicine compound prescription, any Chinese medicine compound prescription can be analyzed, clearly illustrate the information of Chinese medicine compound prescription from pharmacological property Knowledge Element Compatibility Law, the Information Service Level of Chinese medicine system is improved by the system, and tcm clinical is preferably instructed to use and traditional Chinese medicine new drug development.

Description

A kind of Chinese medicine compound prescription information retrieval system
Technical field
The present invention relates to Chinese Traditional Medicine information inquiry applied technical field more particularly to a kind of Chinese medicine compound prescription information retrieval systems.
Background technology
Chinese medicine compound prescription is important component in traditional Chinese medicine, is the principal mode and means of clinical application, resonable, Occupy an important ring in hair, side, medicine.Chinese medicine compound prescription is the difficult point of traditional Chinese medicine basic research for a long time, due to Chinese medicine compound prescription The diversity of formulation ingredients and effect, the complexity of physiological disposition, multi-stratification and centering medical knowledge with living organism effect By the limitation of understanding, pharmacological research pattern substantially continues to use the pharmacological model of Western medicine, is ground by the chemical composition of drug Study carefully, cannot objectively react the main pharmacodynamics of Chinese medicine compound prescription, or by the ingredient of Chinese medicine compound prescription, directly give the master of Chinese medicine compound prescription Effect is wanted, comprehensively the pharmacology of Chinese medicine compound prescription and drug effect cannot be parsed, traditional Chinese medicine is recognized so also can not just popularize Know and understand, then, how comprehensively the pharmacology of Chinese medicine compound prescription and drug effect to show in an intuitive fashion, goes to help people Be better understood by traditional Chinese medicine into problem to be solved primarily now.
Invention content
The present invention provides a kind of Chinese medicine compound prescription information retrieval system for problem of the prior art, can be to Chinese medicine compound prescription information It is retrieved, intuitively can comprehensively show the pharmacology and drug effect of Chinese medicine compound prescription, have analytic function, be conducive to improve traditional Chinese medicine Information Service Level.
In order to solve the above-mentioned technical problem, the present invention adopts the following technical scheme that:A kind of Chinese medicine compound prescription information retrieval system, Including data input module, data retrieval module and data disaply moudle, the data input module connects with data retrieval module It connects, the data retrieval module is connect with data disaply moudle;Data input module, the compound name for inputting information to be checked Claim;Data retrieval module, the Chinese medicine compound prescription title for inputting the data input module carry out effect functional analysis processing; Data disaply moudle, compound effect functional information for analyzing the data retrieval module are shown;
The data retrieval module includes database, pharmacological property content functional analysis module, pharmacological property Compatibility Law functional analysis Module and pharmacological property compatibility express effect functional analysis module, the pharmacological property content functional analysis module, pharmacological property Compatibility Law function Analysis module and pharmacological property compatibility are expressed effect functional analysis module and are connect with the database;
The database is for storing Chinese Traditional Medicine information;The pharmacological property content functional analysis module is for from the database Data are called to carry out the pharmacological property content of the Chinese medicine compound prescription title of retrieval analysis input;The pharmacological property Compatibility Law functional analysis module Pharmacological property compatibility relationship for the Chinese medicine compound prescription title for calling data progress retrieval analysis input from the database;The medicine Property compatibility to express Chinese medicine of effect functional analysis module for calling data to carry out retrieval analysis input from the database multiple The pharmacological property of square title expresses effect content.
Further, the data retrieval module further includes that the compound effect being connect with database is superimposed effect phase with compound Like degree functional analysis module, for analyze compound effect be superimposed effect with compound between similarity, described compound effect with it is multiple Side's superposition effect similarity functional analysis module is defined as follows:
The compound effect %=compounds effect frequency/total frequency * 100% of effect,
Compound is superimposed effect %=compounds and is superimposed the total frequency * 100% of effect frequency/effect,
The total frequency of effect=compound effect frequency+compound is superimposed effect frequency;
A=| compound effect %- compounds are superimposed effect % |, a is the difference that compound effect % is superimposed effect % with compound Absolute value, for the absolute value a of difference closer to 0, the similarity that compound effect is superimposed effect with compound is then higher.
Further, the database includes Chinese medicine compound prescription tables of data, pharmacological property-effect knowledge metadata table, effect knowledge Metadata table, to sick effect knowledge metadata table, verification effect knowledge metadata table, suit the medicine to the illness effect knowledge metadata table, the eight principal syndromes Dialectical effect knowledge metadata table, etiological analysis and differentiation effect knowledge metadata table, the gentle blood of syndrome differentiation of zang-fu viscera effect knowledge metadata table Differentiation of body fluid effect knowledge metadata table;
The Chinese medicine compound prescription tables of data is associated with pharmacological property-effect knowledge metadata table, the pharmacological property-effect knowledge metadata Table is associated with effect knowledge metadata table, it is described to sick effect knowledge metadata table, verification effect knowledge metadata table and suit the medicine to the illness Effect knowledge metadata table is associated with effect knowledge metadata table, and differentiation of eight principles effect knowledge metadata table, the cause of disease are distinguished Demonstrate,prove effect knowledge metadata table, the gentle blood differentiation of body fluid effect knowledge metadata table of syndrome differentiation of zang-fu viscera effect knowledge metadata table with Verify the association of effect knowledge metadata table.
Further, the pharmacological property Compatibility Law functional analysis module includes basic pharmacological property Compatibility Law module and main medicine Property Compatibility Law module, the basic pharmacological property Compatibility Law module be used for analyze retrieval input compound total pharmacological property compatibility advise Rule, the main pharmacological property Compatibility Law module are used to advise total pharmacological property compatibility that basic pharmacological property Compatibility Law module is retrieved Rule is screened, and obtains the main pharmacological property Compatibility Law of the Chinese medicine compound prescription title of input.
Beneficial effects of the present invention:
A kind of Chinese medicine compound prescription information retrieval system provided by the invention can carry out retrieval and inquisition to the information of Chinese medicine compound prescription, Searching system can analyze any Chinese medicine compound prescription, the information of Chinese medicine compound prescription clearly be illustrated from pharmacological property Knowledge Element Compatibility Law, entirely It is what that the effect of Chinese medicine compound prescription of face parsing inquiry, which cures mainly, is which nature and flavor compatibility expresses effect, is how to express effect , the Information Service Level of Chinese medicine system is improved by the system, preferably instructs tcm clinical to use new with traditional Chinese medicine Medicine is developed.
Description of the drawings
Fig. 1 is the systematic schematic diagram of the present invention.
Fig. 2 is the structural schematic diagram of the database of the present invention.
Specific implementation mode
For the ease of the understanding of those skilled in the art, the present invention is made further with reference to embodiment and attached drawing Bright, the content that embodiment refers to not is limitation of the invention.The present invention is described in detail below in conjunction with attached drawing.
A kind of Chinese medicine compound prescription information retrieval system provided by the invention, such as Fig. 1, including data input module, data retrieval Module and data disaply moudle, the data input module are connect with data retrieval module, the data retrieval module and data Display module connects;Data input module, the compound title for inputting information to be checked;Data retrieval module is used for institute The compound title for stating data input module input carries out effect functional analysis processing;Data disaply moudle is used for the data Compound effect functional information that retrieval module analysis obtains is shown;
The data retrieval module includes database, pharmacological property content functional analysis module, pharmacological property Compatibility Law functional analysis Module and pharmacological property compatibility express effect functional analysis module, the pharmacological property content functional analysis module, pharmacological property Compatibility Law function Analysis module and pharmacological property compatibility are expressed effect functional analysis module and are connect with the database;
The database is for storing Chinese Traditional Medicine information;The pharmacological property content functional analysis module is for from the database Data are called to carry out the pharmacological property content of the Chinese medicine compound prescription of retrieval analysis input;The pharmacological property Compatibility Law functional analysis module is used for Data are called to carry out the pharmacological property compatibility relationship of the Chinese medicine compound prescription of retrieval analysis input from the database;The pharmacological property compatibility table The pharmacological property of Chinese medicine compound prescription up to effect functional analysis module for calling data progress retrieval analysis input from the database Express effect content.
Specifically, Knowledge Element refers to the knowledge unit with complete knowledge representation that can not divide again, and herbal nature packet Include four gas, the five tastes and channel tropism, thus pharmacological property Knowledge Element be the temperature of four gas, it is heat, cold, cool, flat, the five tastes it is pungent, sweet, bitter, puckery, Salty, light, sour, liver, courage, lung, spleen, stomach, heart of channel tropism etc., effect Knowledge Element are bushing, kidney tonifying, tonifying liver, invigorating the spleen, stomach invigorating, support Stomach, moistening lung, zhuanggu, strengthening tendons etc. have effects that " V-O construction " word, thus the Compatibility Law of pharmacological property Knowledge Element be four gas, The different pairings of Knowledge Element between the five tastes, channel tropism, it is such as pungent with it is sweet, it is bitter with cold, pungent and bitter etc. compatibility, defined directly with this compatibility See pharmacological property effect content that ground expression compound has.
Such as Fig. 1, user is inputted the title of Chinese medicine compound prescription to be checked by data input module, and selection needs the choosing retrieved , such as selection needs the pharmacological property content retrieved, then pharmacological property content functional analysis module can be by calling related Chinese medicine in database The data of pharmacological property content carry out Analysis and Screening further according to each taste medicine of compound, finally obtain the pharmacological property of Chinese medicine compound prescription to be checked Content includes four gas, the five tastes and the channel tropism of compound, the data information inquired is shown by data disaply moudle;If selection inspection The content of rope is the Compatibility Law of pharmacological property, then pharmacological property Compatibility Law functional analysis module can call related Chinese medicine from database Pharmacological property compatibility relationship carries out Analysis and Screening, obtains the pharmacological property Compatibility Law of Chinese medicine compound prescription to be checked, includes the Knowledge Element of the five tastes The Knowledge Element compatibility of compatibility and nature and flavor, and the data inquired are exported by data outputting module;It is compound if necessary to retrieval Expression effect, then pharmacological property compatibility express effect functional analysis module can be by calling related data in database, according to compound medicine Property Knowledge Element compatibility analyzed, finally by data disaply moudle show coordinate indexing result;Alternatively, the multiple inspections of simultaneous selection Rope content, multiple retrieval modules in data retrieval module can call data from database, carry out retrieval analysis, finally simultaneously It obtains all information to be checked of compound and is shown by data disaply moudle.
In present embodiment, such as Fig. 1, further, the data retrieval module further includes the compound being connect with database Effect is superimposed effect similarity functional analysis module with compound, for analyze compound effect be superimposed effect with compound between it is similar Degree, described compound effect are superimposed effect similarity functional analysis module with compound and are defined as follows:
The compound effect %=compounds effect frequency/total frequency * 100% of effect,
Compound is superimposed effect %=compounds and is superimposed the total frequency * 100% of effect frequency/effect,
The total frequency of effect=compound effect frequency+compound is superimposed effect frequency;
A=| compound effect %- compounds are superimposed effect % |, a is the difference that compound effect % is superimposed effect % with compound, poor For value a closer to 0, the similarity that compound effect is superimposed effect with compound is then higher.
Specifically, such as table 1, when retrieval analysis, different numbers is had behind each effect, each number, which represents, meets this The Chinese medicine number of power condition, referred to as frequency, compound effect refer to the effect of medicine property of medicine of Chinese medicine compound prescription is expressed after compatibility again, Compound be superimposed effect refer to compound medicine effect it is superimposed to the effect of;Compound effect is superimposed effect with compound resemblance, Each different efficacies being superimposed according to compound or compound account for the proportion of total effect and are superimposed work(to weigh compound effect and compound Similarity between effect, according to formula, the compound effect %=compounds effect frequency/total frequency * 100% of effect, compound is superimposed work( Effect %=compounds are superimposed the total frequency * 100% of effect frequency/effect, the wherein total frequency of effect=compound effect frequency+compound superposition Effect frequency, it is a=that the percentage of compound effect, which is superimposed the percentage difference of effect with compound, | compound effect %- compounds are superimposed Effect % |, judged to be superimposed the similarity of effect with compound to compound by difference a, when difference a is closer to 0, compound effect The similarity that effect is superimposed with compound is then higher.
Table 1
In present embodiment, such as Fig. 2, the database includes Chinese medicine compound prescription tables of data, pharmacological property-effect knowledge metadata Table, effect knowledge metadata table, to sick effect knowledge metadata table, verification effect knowledge metadata table, effect Knowledge Element of suiting the medicine to the illness Tables of data, differentiation of eight principles effect knowledge metadata table, etiological analysis and differentiation effect knowledge metadata table, syndrome differentiation of zang-fu viscera effect Knowledge Element number According to table and differentiation of qi-blood-body fluid effect knowledge metadata table;
The Chinese medicine compound prescription tables of data is associated with pharmacological property-effect knowledge metadata table, the pharmacological property-effect knowledge metadata Table is associated with effect knowledge metadata table, it is described to sick effect knowledge metadata table, verification effect knowledge metadata table and suit the medicine to the illness Effect knowledge metadata table is associated with effect knowledge metadata table, and differentiation of eight principles effect knowledge metadata table, the cause of disease are distinguished Demonstrate,prove effect knowledge metadata table, the gentle blood differentiation of body fluid effect knowledge metadata table of syndrome differentiation of zang-fu viscera effect knowledge metadata table with Verify the association of effect knowledge metadata table.
Specifically, such as Fig. 2, database determines Chinese medicine compound prescription tables of data, pharmacological property-effect knowledge metadata table, effect Knowledge metadata table, to sick effect knowledge metadata table, verification effect knowledge metadata table, effect knowledge metadata table of suiting the medicine to the illness, Differentiation of eight principles effect knowledge metadata table, etiological analysis and differentiation effect knowledge metadata table, syndrome differentiation of zang-fu viscera effect knowledge metadata table and Differentiation of qi-blood-body fluid effect knowledge metadata table, totally 10 tables of data are calling data since there are many field of each table design When library, the access frequency of each field is not quite similar in tables of data, and directly all fields are stored in a table can shadow The frequency accessed is rung, therefore database needs multiple tables to realize, one is associated in by the public field of table between these tables It rises;It is associated by common medicine file-name field between Chinese medicine compound prescription tables of data and pharmacological property-effect knowledge metadata table, pharmacological property-work( It is associated by common effect field between effect knowledge metadata table and effect knowledge metadata table, effect knowledge metadata table Sick effect field is associated by common between sick effect knowledge metadata table, effect knowledge metadata table and verification Effect knowledge metadata table is associated by common verification effect field, effect knowledge metadata table and effect Knowledge Element to the ill Tables of data is associated by common effect field of suiting the medicine to the illness, verification effect knowledge metadata table and differentiation of eight principles effect Knowledge Element number It is associated by common differentiation of eight principles effect field according between table, verification effect knowledge metadata table is known with etiological analysis and differentiation effect It is associated by common etiological analysis and differentiation effect field between knowledge metadata table, verifies effect knowledge metadata table and syndrome differentiation of zang-fu viscera It is associated by common syndrome differentiation of zang-fu viscera effect field between effect knowledge metadata table, verifies effect knowledge metadata table and gas It is associated by common differentiation of qi-blood-body fluid effect field between blood differentiation of body fluid effect knowledge metadata table;Database spirit It is living to use multiple tables of data, it is contacted by same field so that the same field of different data table is used in conjunction with, and improves data The access speed in library.
In present embodiment, the pharmacological property Compatibility Law functional analysis module includes basic pharmacological property Compatibility Law module and master Pharmacological property Compatibility Law module, the basic pharmacological property Compatibility Law module is wanted to be used to analyze total pharmacological property compatibility of the compound of retrieval input Rule, total pharmacological property compatibility that the main pharmacological property Compatibility Law module is used to retrieve basic pharmacological property Compatibility Law module Rule is screened, and obtains the main pharmacological property Compatibility Law of the Chinese medicine compound prescription of input.
Specifically, compound medicine pharmacological property reconfigures, and the combination of pharmacological property Knowledge Element compatibility has very much, is not each compatibility form Its effect is all expressed, thus in addition to designing basic pharmacological property Compatibility Law module, main pharmacological property Compatibility Law module is also designed, to multiple The main pharmacological property compatibility in side carries out more comprehensive analysis.Pharmacological property-effect knowledge metadata table is called first, filters out compound The combination and compatibility of pharmacological property Knowledge Element, then qualified Chinese medicine is screened by the pharmacological property content of compound, and analyze eligible Chinese medicine frequency, calculate the average value of the Chinese medicine frequency of each corresponding pharmacological property Knowledge Element combination, wherein Chinese medicine frequency is more than average The nature and flavor Knowledge Element of value is combined as the main pharmacological property Knowledge Element compatibility that compound expresses effect, conversely, the nature and flavor less than average value are known It is not the main pharmacological property compatibility Knowledge Element that compound expresses effect to know member combination.Thus, pharmacological property Compatibility Law functional analysis module is not Whole pharmacological property Knowledge Element compatibilities of compound can only be retrieved, moreover it is possible to show the main pharmacological property Knowledge Element compatibility of the compound of retrieval, this Make user more acurrate for the application of compound.
The above is only present pre-ferred embodiments, is not intended to limit the present invention in any form, although The present invention is disclosed as above with preferred embodiment, and however, it is not intended to limit the invention, any person skilled in the art, It does not depart within the scope of technical solution of the present invention, when the technology contents using the disclosure above make a little change or are modified to equivalent change The equivalent embodiment of change, as long as being without departing from technical solution of the present invention content, technology refers to above example according to the present invention Made by any simple modification, equivalent change and modification, belong in the range of technical solution of the present invention.

Claims (4)

1. a kind of Chinese medicine compound prescription information retrieval system, it is characterised in that:Including data input module, data retrieval module and data Display module, the data input module are connect with data retrieval module, and the data retrieval module connects with data disaply moudle It connects;
Data input module, the compound title for inputting information to be checked;Data retrieval module, for inputting the data The Chinese medicine compound prescription title of module input carries out effect functional analysis processing;Data disaply moudle is used for the data retrieval mould Compound effect functional information that block analysis obtains is shown;
The data retrieval module includes database, pharmacological property content functional analysis module, pharmacological property Compatibility Law functional analysis module Effect functional analysis module, the pharmacological property content functional analysis module, pharmacological property Compatibility Law functional analysis are expressed with pharmacological property compatibility Module and pharmacological property compatibility are expressed effect functional analysis module and are connect with the database;
The database is for storing Chinese Traditional Medicine information;
The pharmacological property content functional analysis module for calling data to carry out the Chinese medicine of retrieval analysis input from the database The pharmacological property content of compound title;
The pharmacological property Compatibility Law functional analysis module for calling data to carry out retrieval analysis input from the database The pharmacological property compatibility relationship of Chinese medicine compound prescription title;
It is defeated for calling data to carry out retrieval analysis from the database that the pharmacological property compatibility expresses effect functional analysis module The pharmacological property of the Chinese medicine compound prescription title entered expresses effect content.
2. a kind of Chinese medicine compound prescription information retrieval system according to claim 1, it is characterised in that:The data retrieval module is also Include that the compound effect being connect with database is superimposed effect similarity functional analysis module with compound, for analyze compound effect with Compound is superimposed the similarity between effect, and described compound effect is superimposed the definition of effect similarity functional analysis module with compound such as Under:
The compound effect %=compounds effect frequency/total frequency * 100% of effect,
Compound is superimposed effect %=compounds and is superimposed the total frequency * 100% of effect frequency/effect,
The total frequency of effect=compound effect frequency+compound is superimposed effect frequency;
A=| compound effect %- compounds are superimposed effect % |, a is the absolute of the difference that compound effect % is superimposed effect % with compound Value, for the absolute value a of difference closer to 0, the similarity that compound effect is superimposed effect with compound is then higher.
3. a kind of Chinese medicine compound prescription information retrieval system according to claim 1, it is characterised in that:The database includes Chinese medicine Compound tables of data, pharmacological property-effect knowledge metadata table, effect knowledge metadata table, to sick effect knowledge metadata table, verification work( Imitate knowledge metadata table, suit the medicine to the illness effect knowledge metadata table, differentiation of eight principles effect knowledge metadata table, etiological analysis and differentiation effect knowledge The gentle blood differentiation of body fluid effect knowledge metadata table of metadata table, syndrome differentiation of zang-fu viscera effect knowledge metadata table;
The Chinese medicine compound prescription tables of data is associated with pharmacological property-effect knowledge metadata table, the pharmacological property-effect knowledge metadata table with Effect knowledge metadata table is associated with, described to sick effect knowledge metadata table, verification effect knowledge metadata table and effect to the ill Knowledge metadata table is associated with effect knowledge metadata table, differentiation of eight principles effect knowledge metadata table, etiological analysis and differentiation work( Imitate knowledge metadata table, the gentle blood differentiation of body fluid effect knowledge metadata table of syndrome differentiation of zang-fu viscera effect knowledge metadata table with verification Effect knowledge metadata table is associated with.
4. a kind of Chinese medicine compound prescription information retrieval system according to claim 1, it is characterised in that:The pharmacological property Compatibility Law work( Energy analysis module includes basic pharmacological property Compatibility Law module and main pharmacological property Compatibility Law module, the basic pharmacological property Compatibility Law Module is used to analyze total pharmacological property Compatibility Law of the Chinese medicine compound prescription title of retrieval input, and the main pharmacological property Compatibility Law module is used It is screened in total pharmacological property Compatibility Law that basic pharmacological property Compatibility Law module is retrieved, obtains the Chinese medicine compound prescription of input Main pharmacological property Compatibility Law.
CN201810333542.9A 2018-04-13 2018-04-13 A kind of Chinese medicine compound prescription information retrieval system Pending CN108735304A (en)

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