CN108697729B - 新型GLUT抑制剂rapaglutin及其用途 - Google Patents

新型GLUT抑制剂rapaglutin及其用途 Download PDF

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CN108697729B
CN108697729B CN201780010180.3A CN201780010180A CN108697729B CN 108697729 B CN108697729 B CN 108697729B CN 201780010180 A CN201780010180 A CN 201780010180A CN 108697729 B CN108697729 B CN 108697729B
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cancer
glucose
cells
inhibition
cell
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CN108697729A (zh
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J·刘
J·王
Z·郭
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Johns Hopkins University
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    • A—HUMAN NECESSITIES
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
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    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
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    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201780010180.3A 2016-02-04 2017-02-03 新型GLUT抑制剂rapaglutin及其用途 Active CN108697729B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662291453P 2016-02-04 2016-02-04
US62/291,453 2016-02-04
PCT/US2017/016516 WO2017136731A1 (en) 2016-02-04 2017-02-03 Rapaglutins, novel inhibitors of glut and use thereof

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CN108697729A CN108697729A (zh) 2018-10-23
CN108697729B true CN108697729B (zh) 2023-05-09

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US (1) US11708391B2 (https=)
EP (1) EP3411046B1 (https=)
JP (1) JP7104627B2 (https=)
CN (1) CN108697729B (https=)
AU (1) AU2017213630B2 (https=)
CA (1) CA3013783A1 (https=)
MX (1) MX2018009408A (https=)
WO (1) WO2017136731A1 (https=)

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CA3013783A1 (en) 2016-02-04 2017-08-10 The Johns Hopkins University Rapaglutins, novel inhibitors of glut and use thereof
US11066416B2 (en) 2016-02-04 2021-07-20 The Johns Hopkins University Rapafucin derivative compounds and methods of use thereof
WO2021067405A1 (en) * 2019-10-01 2021-04-08 The Johns Hopkins University Neuroprotective compounds and methods of use thereof
TW202126323A (zh) 2019-10-01 2021-07-16 約翰斯赫普金斯大學 雷帕弗辛（Ｒａｐａｆｕｃｉｎ）衍生化合物及其使用方法
CN112294792B (zh) * 2020-09-22 2021-10-22 厦门市中医院 化合物wzb117在制备治疗和/或预防肝损伤药物中的用途
CN115364224B (zh) * 2022-08-25 2024-02-02 杭州天玑济世生物科技有限公司 Glut1抑制剂作为线粒体自噬诱导剂的用途
CN120271673A (zh) * 2024-01-08 2025-07-08 重庆医科大学 一种化合物、包含其的药物组合物及其用途
CN120617307B (zh) * 2025-06-16 2025-12-09 烟台大学 一种wzb117纳米制剂及其制备方法

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WO2017136731A1 (en) 2017-08-10
AU2017213630B2 (en) 2022-05-12
CA3013783A1 (en) 2017-08-10
US11708391B2 (en) 2023-07-25
AU2017213630A1 (en) 2018-08-16
MX2018009408A (es) 2018-11-09
US20210214390A1 (en) 2021-07-15
CN108697729A (zh) 2018-10-23
EP3411046A1 (en) 2018-12-12
JP2019504087A (ja) 2019-02-14
JP7104627B2 (ja) 2022-07-21
EP3411046B1 (en) 2025-07-16
EP3411046A4 (en) 2019-11-27
WO2017136731A8 (en) 2018-08-23

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