CN108689887A - A kind of method of industrialized production L-arginine-ASPARTIC ACID - Google Patents
A kind of method of industrialized production L-arginine-ASPARTIC ACID Download PDFInfo
- Publication number
- CN108689887A CN108689887A CN201810364643.2A CN201810364643A CN108689887A CN 108689887 A CN108689887 A CN 108689887A CN 201810364643 A CN201810364643 A CN 201810364643A CN 108689887 A CN108689887 A CN 108689887A
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- CN
- China
- Prior art keywords
- arginine
- aspartic acid
- added
- tons
- industrialized production
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
- C07C227/42—Crystallisation
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The present invention relates to a kind of methods of industrialized production L-arginine-ASPARTIC ACID, clear water 5000-6000L is added in 10T material-compound tanks, open stirring, 1-1.8 tons of L-arginine is added, its mass concentration is in 20%-30%, after L-arginine all dissolving, it is slowly added to 0.76-1.37 tons of ASPARTIC ACID, wherein L-arginine:ASPARTIC ACID mass ratio is(1.30-1.32:1), PH=6.7-7.0, normal-temperature reaction 10-20min are measured, activated carbon 5-10kg, decoloration, press filtration to concentration tank is added;It is warming up to 55-60 DEG C, is decompressed to 0.8-1.0Mpa, is concentrated into be=20-30, is put into truck, 10-20gL- arginine-ASPARTIC ACID finished product induction crystallization is added, discharges, drying obtains 1.7-3 tons of finished product, and yield reaches 96-98%.Products obtained therefrom crystal form of the present invention is good, and stable quality is readily transported and uses, while also having product purity height, high income, is adapted to industrialized production.
Description
Technical field
The invention belongs to food, medicine and chemical fields, and in particular to a kind of L-arginine-ASPARTIC ACID of producing
Method.
Background technology
L-arginine-ASPARTIC ACID(L-Arginine-L-Aspartate), it is a kind of white crystals or crystal type
Powder, slightly special taste, there is tart flavour.This product is readily soluble in water, dissolves in ethanol, insoluble in ether or n-butanol.
Chemical formula:C10H21N5O6, molecular weight:307.31, chemical structural formula:
。
L-arginine-ASPARTIC ACID is using ASPARTIC ACID and L-arginine as raw material in prior art, water-soluble
L-arginine-ASPARTIC ACID double salt is synthesized by acid-base reaction in liquid system, confirms L- by detecting solution system PH
Arginine and ASPARTIC ACID molar ratio=1:1.Extracting method is:1. changing solvent polarity using organic solvent, to make production
Product are precipitated to obtain finished product.Using organic solvent, high, and shop safety class requirement is required production equipment, environment etc.
It increases substantially, increases the Meteorological of fixation means;Easy residual organic solvent in the product obtained simultaneously, and use
Organic solvent extraction can increase cost of material;2. Direct spraying drying equipment, place are thrown, big, energy consumption is of high cost;It is obtained
The granularity of product is poor, and moisture is unstable, is difficult to control.
Invention content
Goal of the invention:Purpose of the invention is to overcome the shortcomings in the prior art, provides a kind of products obtained therefrom crystal form
Good, stable quality is readily transported and uses, while also having product purity height, high income, is adapted to the L- essences of industrialized production
The method of propylhomoserin-ASPARTIC ACID.
Technical solution:In order to solve the above-mentioned technical problem, a kind of industrialized production L-arginine of the present invention-L- days
Clear water 5000-6000L is added in the method for L-aminobutanedioic acid in 10T material-compound tanks, opens stirring, and 1-1.8 tons of L-arginine is added,
Its mass concentration is slowly added to 0.76-1.37 tons of ASPARTIC ACID in 20%-30% after L-arginine all dissolving, wherein
L-arginine:ASPARTIC ACID mass ratio is(1.30-1.32:1), PH=6.7-7.0, normal-temperature reaction 10-20min are measured,
Activated carbon 5-10kg, decoloration, press filtration to concentration tank is added;Be warming up to 55-60 DEG C, be decompressed to 0.8-1.0Mpa, be concentrated into be=
20-30 is put into truck, and 10-20gL- arginine-ASPARTIC ACID finished product induction crystallization is added, discharges, drying obtains finished product
1.7-3 tons, yield reaches 96-98%.
In 10T material-compound tanks, L-arginine is added:ASPARTIC ACID mass ratio is 1.31:1.
The drying temperature is 110-120 DEG C.
Advantageous effect:Compared with prior art, the present invention its remarkable advantage is:The technique dispensing of the present invention, reaction etc. are given birth to
It is identical as former technique to produce process, reaction solution is concentrated into suitable concentration in abstraction process, first quiescent crystallization is opened after graining and stirred
Continue low temperature concentration makes the crystallization of double salt product be precipitated using the method for induction crystallization, then by centrifuging, drying to obtain product, gained
Product crystal form it is good, stable quality is readily transported and uses, while the purity also with product high (>=99%), high income
The advantages that (96-98%), it is adapted to industrialized production.
Specific implementation mode
The present invention is further detailed with reference to embodiment.
Embodiment 1
A kind of method of industrialized production L-arginine-ASPARTIC ACID of the present invention is added clear in 10T material-compound tanks
Water 5400L opens stirring, and 1.5 tons of L-arginine is added, and mass concentration after L-arginine all dissolving, is delayed 27.8%
It is slow that 1.14 tons of ASPARTIC ACID, wherein L-arginine is added:ASPARTIC ACID mass ratio is 1.31:1, PH=6.8 are measured,
Activated carbon 7kg, decoloration, press filtration to concentration tank is added in normal-temperature reaction 15min;57 DEG C are warming up to, 0.8Mpa is decompressed to, is concentrated into
Be=26 are put into truck, and 15gL- arginine-ASPARTIC ACID finished product induction crystallization, discharging is added, and 115 DEG C of drying are obtained into
Product.
Embodiment 2
A kind of method of industrialized production L-arginine-ASPARTIC ACID of the present invention is added clear in 10T material-compound tanks
Water 5800L opens stirring, and 1.6 tons of L-arginine is added, and mass concentration after L-arginine all dissolving, is delayed 27.6%
It is slow that 1.22 tons of ASPARTIC ACID, wherein L-arginine is added:ASPARTIC ACID mass ratio is 1.31:1, PH=6.9 are measured,
Activated carbon 9kg, decoloration, press filtration to concentration tank is added in normal-temperature reaction 18min;58 DEG C are warming up to, 0.9Mpa is decompressed to, is concentrated into
Be=28 are put into truck, and 18gL- arginine-ASPARTIC ACID finished product induction crystallization, discharging is added, and 118 DEG C of drying are obtained into
Product.
Technique dispensing, the production processes such as reaction of the present invention are identical as original technique, are concentrated into reaction solution in abstraction process
Suitable concentration, first quiescent crystallization, stirring is opened after graining continue low temperature concentration makes double salt product knot using the method for induction crystallization
Partial crystallization goes out, then by centrifuging, drying to obtain product, resulting product crystal form is good, stable quality, is readily transported and uses, simultaneously
Also have many advantages, such as purity high (>=99%), the high income (96-98%) of product, is adapted to industrialized production.
The present invention provides a kind of thinking and methods, and there are many method and the approach for implementing the technical solution, the above institute
State only is the preferred embodiment of the present invention, it is noted that for those skilled in the art, is not being departed from
Under the premise of the principle of the invention, several improvements and modifications can also be made, these improvements and modifications also should be regarded as the guarantor of the present invention
Range is protected, all undefined components in this embodiment can be implemented in the prior art.
Claims (3)
1. a kind of method of industrialized production L-arginine-ASPARTIC ACID, it is characterised in that:It is added in 10T material-compound tanks
Clear water 5000-6000L opens stirring, and 1-1.8 tons of L-arginine is added, and mass concentration waits for that L-arginine is complete in 20%-30%
After portion's dissolving, it is slowly added to 0.76-1.37 tons of ASPARTIC ACID, wherein L-arginine:ASPARTIC ACID mass ratio is
(1.30-1.32:1), measure PH=6.7-7.0, normal-temperature reaction 10-20min, be added activated carbon 5-10kg, decoloration, press filtration is to dense
Contracting tank;It is warming up to 55-60 DEG C, is decompressed to 0.8-1.0Mpa, is concentrated into be=20-30, is put into truck, 10-20gL- essence ammonia is added
Acid-ASPARTIC ACID finished product induction crystallization, discharges, and drying obtains 1.7-3 tons of finished product, and yield reaches 96-98%.
2. the method for industrialized production L-arginine-ASPARTIC ACID according to claim 1, it is characterised in that:
In 10T material-compound tanks, L-arginine is added:ASPARTIC ACID mass ratio is 1.31:1.
3. the method for industrialized production L-arginine-ASPARTIC ACID according to claim 1, it is characterised in that:Institute
It is 110-120 DEG C to state drying temperature.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810364643.2A CN108689887A (en) | 2018-04-23 | 2018-04-23 | A kind of method of industrialized production L-arginine-ASPARTIC ACID |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810364643.2A CN108689887A (en) | 2018-04-23 | 2018-04-23 | A kind of method of industrialized production L-arginine-ASPARTIC ACID |
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| Publication Number | Publication Date |
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| CN108689887A true CN108689887A (en) | 2018-10-23 |
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| CN201810364643.2A Pending CN108689887A (en) | 2018-04-23 | 2018-04-23 | A kind of method of industrialized production L-arginine-ASPARTIC ACID |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1625M (en) * | 1964-12-21 | 1962-12-26 | Georges Negrevergne | Drug with nutritive and antitoxic action. |
| US5019558A (en) * | 1988-05-09 | 1991-05-28 | Georges Cehovic | Method for treating memory disturbances using arginine aspartate |
| US5227007A (en) * | 1990-09-28 | 1993-07-13 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing crystals of salt of acidic amino acid and basic amino acid |
| CN101591257A (en) * | 2008-05-27 | 2009-12-02 | 上海汉飞生化科技有限公司 | A kind of preparation method of crystal L-arginine L-aspartate |
| CN102102118A (en) * | 2009-12-18 | 2011-06-22 | 上海汉飞生化科技有限公司 | Method for preparing L-ornithine-L-aspartate salt |
-
2018
- 2018-04-23 CN CN201810364643.2A patent/CN108689887A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1625M (en) * | 1964-12-21 | 1962-12-26 | Georges Negrevergne | Drug with nutritive and antitoxic action. |
| US5019558A (en) * | 1988-05-09 | 1991-05-28 | Georges Cehovic | Method for treating memory disturbances using arginine aspartate |
| US5227007A (en) * | 1990-09-28 | 1993-07-13 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing crystals of salt of acidic amino acid and basic amino acid |
| CN101591257A (en) * | 2008-05-27 | 2009-12-02 | 上海汉飞生化科技有限公司 | A kind of preparation method of crystal L-arginine L-aspartate |
| CN102102118A (en) * | 2009-12-18 | 2011-06-22 | 上海汉飞生化科技有限公司 | Method for preparing L-ornithine-L-aspartate salt |
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Application publication date: 20181023 |