CN108686031B - Traditional Chinese medicine composition for treating influenza and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating influenza and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating influenza. The feed is prepared from the following substances in parts by weight: 6-12 parts of mulberry leaf extract, 6-12 parts of perilla leaf extract, 10-20 parts of loquat leaf extract, 10-20 parts of oriental wormwood extract, 6-12 parts of microcos paniculata extract, 6-12 parts of platycodon root extract, 6-12 parts of figwort root extract, 15-30 parts of kudzuvine root extract, 4-8 parts of liquorice extract, 8-12 parts of wrinkled gianthyssop herb extract, 2-6 parts of medicated leaven, 10-30 parts of starch and 3-8 parts of magnesium stearate. The traditional Chinese medicine composition for treating influenza has a good treatment effect on common influenza, is low in recurrence rate after curing, wide in raw material source, low in side effect after taking most of extracts from plant traditional Chinese medicines, and suitable for large-scale industrial production.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine preparation, and particularly relates to a traditional Chinese medicine composition for treating influenza and a preparation method thereof.
Background
Influenza is an acute febrile respiratory infectious disease caused by influenza virus, is spread by droplets, and is clinically typical to be manifested by systemic poisoning symptoms such as prominent aversion to cold, high fever, headache, general aching pain, fatigue and hypodynamia, and the respiratory symptoms are light. The disease is usually self-limiting, and the course of disease is usually 3-4 days. Infants, the elderly, patients with cardiopulmonary disease and other chronic diseases or patients with low immune function can develop pneumonia, and the prognosis is poor.
Influenza virus is an RNA virus, in the form of spherical particles, whose structure is divided into 3 layers from the outside to the inside: lipid envelope, globular protein shell, and core shell. The lipocapsids are derived from host cells and are composed of neuraminidase, hemagglutinin and M2 protein. HA and NA determine the antigenicity of the virus, and when their composition and structure are altered, the antigenic properties of the virus are altered. At present, 16 subtypes of HA and 9 subtypes of NA are found, wherein HA of H1-3 subtype and NA influenza virus of N1-2 subtype are relatively common in infected human population. The M2 protein is the target of the action of the antiviral drugs amantadine and rimantadine. The nucleocapsid is the region of storage of viral genetic material, containing the genetic material RNA.
The influenza vaccine has a certain effect on preventing influenza virus infection, but the development of the vaccine is difficult and serious due to strong variability and various varieties of the influenza virus. The traditional Chinese medicine has unique advantages in preventing and treating influenza. Modern pharmacological and clinical research shows that the Chinese medicine has obvious inhibition on various influenza viruses, broad-spectrum antiviral property and good killing and inhibiting effect on variant viruses. In addition, the traditional Chinese medicine also has the effects of relieving fever, regulating immunity, inhibiting inflammatory reaction and the like, which is an advantage that general antiviral western medicines do not have. Meanwhile, the traditional Chinese medicine can enhance the individual resistance by combining the traditional Chinese medicine treatment, and can achieve the purposes of stabilizing the curative effect and recovering the health. However, the traditional Chinese medicine for treating influenza at present has poor taste and slow treatment effect, and has different and unstable treatment effects on patients with different body systems and low cure rate.
Disclosure of Invention
The invention discloses a traditional Chinese medicine composition for treating influenza and a preparation method thereof.
A traditional Chinese medicine composition for treating influenza is prepared from the following substances in parts by weight: 6-12 parts of mulberry leaf extract, 6-12 parts of perilla leaf extract, 10-20 parts of loquat leaf extract, 10-20 parts of oriental wormwood extract, 6-12 parts of microcos paniculata extract, 6-12 parts of platycodon root extract, 6-12 parts of figwort root extract, 15-30 parts of kudzuvine root extract, 4-8 parts of liquorice extract, 8-12 parts of wrinkled gianthyssop herb extract, 2-6 parts of medicated leaven, 10-30 parts of starch and 3-8 parts of magnesium stearate.
The extraction method of the mulberry leaf extract comprises the following steps: taking mulberry leaves, drying in the sun, grinding into powder, adding 3-8 times of water by weight, refluxing and extracting for 3 times, combining filtrates, and evaporating to dryness to obtain the mulberry leaf tea;
the extraction method of the perilla leaf extract comprises the following steps: taking folium Perillae, drying in the sun, grinding into powder, adding 5-10 times of water by weight, reflux extracting for 3 times, mixing filtrates, and evaporating to dryness to obtain the final product.
The extraction method of the loquat leaf extract comprises the following steps: drying folium Eriobotryae, grinding into powder, adding 4-12 times of 70% ethanol water solution, reflux extracting for 3 times, mixing filtrates, and evaporating to dryness;
the extraction method of the herba artemisiae scopariae extract comprises the following steps: drying herba Artemisiae Scopariae in the sun, grinding into powder, extracting with 4-8 times of 70% ethanol water solution under reflux for 3 times, mixing filtrates, and evaporating to dryness; .
The extraction method of the microcos paniculata leaf extract comprises the following steps: collecting folium Microcoris Paniculatae, sun drying, grinding into powder, reflux extracting with 4-8 times of 30% ethanol water solution for 3 times, mixing filtrates, and evaporating to dry.
The extraction method of the platycodon extract comprises the following steps: sun drying radix Platycodi, grinding into powder, soaking in 5-10 times of 1% malic acid water solution for 3-5 days, filtering, recovering soaking solution, decolorizing with active carbon, and evaporating to dryness.
The extraction method of the figwort root extract comprises the following steps: taking radix scrophulariae, drying in the sun, grinding into powder, adding 5-12 times of water by weight, reflux extracting for 3 times, combining filtrates, and evaporating to dryness to obtain the product.
The extraction method of the kudzu root extract comprises the following steps: drying radix Puerariae in the sun, grinding into powder, extracting with 5-12 times of water under reflux for 3 times, mixing filtrates, and evaporating to dryness.
The extraction method of the licorice extract comprises the following steps: drying Glycyrrhrizae radix in the sun, grinding into powder, soaking in 5-10 times of 1% tartaric acid water solution for 3-5 days, filtering, recovering soaking solution, decolorizing with active carbon, and evaporating to dryness.
The extraction method of the ageratum extract comprises the following steps: sun drying herba Agastaches, grinding into powder, soaking in 5-10 times of 1% sodium chloride water solution for 3-5 days, filtering, recovering soaking solution, decolorizing with active carbon, and evaporating to dryness.
The preparation method of the traditional Chinese medicine composition for treating influenza comprises the following steps:
(1) according to the weight parts, taking 6-12 parts of mulberry leaf extract, 6-12 parts of perilla leaf extract, 10-20 parts of loquat leaf extract, 10-20 parts of oriental wormwood extract, 6-12 parts of microcos paniculata leaf extract, 6-12 parts of platycodon root extract, 6-12 parts of figwort root extract, 15-30 parts of kudzu root extract, 4-8 parts of liquorice root extract, 8-12 parts of wrinkled gianthyssop herb extract, 2-6 parts of medicated leaven and 10-30 parts of starch, stirring for 10-30min, and uniformly mixing;
(2) making into granules with a dry-process granulator, wherein the particle size of the prepared granules is 60-100 meshes;
(3) taking 3-8 parts of magnesium stearate, mixing with the granules prepared in the step (2), and filling into capsules, wherein the capsule size is 0.2-0.8 g;
(4) and polishing, screening, internally packaging into bottles, externally packaging to obtain finished products, and warehousing after the finished products are qualified.
The invention has the beneficial effects that: the traditional Chinese medicine composition for treating influenza has a good treatment effect on common influenza, is low in recurrence rate after curing, wide in raw material source, low in side effect after taking most of extracts from plant traditional Chinese medicines, and suitable for large-scale industrial production.
Detailed Description
The present invention is further illustrated by the following specific examples.
In the following examples, the extraction method of the Chinese medicinal extract is as follows:
the extraction method of the mulberry leaf extract comprises the following steps: taking mulberry leaves, drying in the sun, grinding into powder, adding 5 times of water by weight, refluxing and extracting for 3 times, combining filtrates, and evaporating to dryness to prepare the mulberry leaf tea;
the extraction method of the perilla leaf extract comprises the following steps: taking perilla leaves, drying in the sun, grinding into powder, adding 7 times of water by weight, refluxing and extracting for 3 times, combining filtrates, and evaporating to dryness to prepare the perilla leaf tea.
The extraction method of the loquat leaf extract comprises the following steps: loquat leaves are taken, dried in the sun and ground into powder, 70 percent ethanol water solution with the weight part being 8 times of that of the loquat leaves is added for reflux extraction for 3 times, and the loquat leaves are prepared by combining filtrates and evaporating to dryness;
the extraction method of the herba artemisiae capillaris extract comprises the following steps: taking herba artemisiae scopariae, drying in the sun, grinding into powder, adding 70% ethanol water solution with the weight part 6 times of that of the powder, performing reflux extraction for 3 times, combining filtrates, and evaporating to dryness to obtain the herba artemisiae scopariae powder; .
The extraction method of the microcos paniculata leaf extract comprises the following steps: taking the microcos paniculata, drying in the sun, grinding into powder, adding 30% ethanol water solution in 6 times of weight portion, reflux-extracting for 3 times, combining filtrates, and evaporating to dryness to obtain the product.
The extraction method of the platycodon extract comprises the following steps: the platycodon grandiflorum is dried in the sun, ground into powder, added with 1% malic acid water solution with the weight part being 8 times that of the platycodon grandiflorum, soaked for 4 days, filtered, the soak solution is recovered, decolored by active carbon and evaporated to dryness to prepare the platycodon grandiflorum.
The extraction method of the figwort root extract comprises the following steps: taking radix scrophulariae, drying in the sun, grinding into powder, adding 8 times of water by weight, refluxing and extracting for 3 times, combining filtrates, and evaporating to dryness to obtain the radix scrophulariae tea.
The extraction method of the kudzu root extract comprises the following steps: drying radix Puerariae in the sun, grinding into powder, extracting with 8 times of water under reflux for 3 times, mixing filtrates, and evaporating to dryness.
The extraction method of the licorice extract comprises the following steps: drying Glycyrrhrizae radix in the sun, grinding into powder, soaking in 7 times of 1% tartaric acid water solution for 4 days, filtering, recovering soaking solution, decolorizing with active carbon, and evaporating to dryness.
The extraction method of the ageratum extract comprises the following steps: sun drying herba Agastaches, grinding into powder, soaking in 7 times of 1% sodium chloride water solution for 4 days, filtering, recovering soaking solution, decolorizing with active carbon, and evaporating to dryness.
Example 1
A traditional Chinese medicine composition for treating influenza is prepared from the following substances in parts by weight: 8 parts of mulberry leaf extract, 8 parts of perilla leaf extract, 15 parts of loquat leaf extract, 15 parts of oriental wormwood extract, 8 parts of microcos paniculata leaf extract, 8 parts of platycodon grandiflorum extract, 8 parts of figwort root extract, 20 parts of kudzu root extract, 6 parts of liquorice extract, 10 parts of wrinkled gianthyssop herb extract, 4 parts of medicated leaven, 20 parts of starch and 5 parts of magnesium stearate.
The preparation method of the traditional Chinese medicine composition for treating influenza comprises the following steps:
(1) according to the weight parts, taking 8 parts of mulberry leaf extract, 8 parts of perilla leaf extract, 15 parts of loquat leaf extract, 15 parts of oriental wormwood extract, 8 parts of microcos paniculata leaf extract, 8 parts of platycodon grandiflorum extract, 8 parts of figwort root extract, 20 parts of kudzu root extract, 6 parts of liquorice extract, 10 parts of wrinkled gianthyssop herb extract, 4 parts of medicated leaven and 20 parts of starch, stirring for 20min, and uniformly mixing;
(2) making into granules with a dry-process granulator, wherein the particle size of the prepared granules is 80 meshes;
(3) taking 5 parts of magnesium stearate, mixing with the granules prepared in the step (2), and filling into capsules, wherein the weight of each capsule is 0.5 g;
(4) and polishing, screening, internally packaging into bottles, externally packaging to obtain finished products, and warehousing after the finished products are qualified.
Example 2
A traditional Chinese medicine composition for treating influenza is prepared from the following substances in parts by weight: 6 parts of mulberry leaf extract, 6 parts of perilla leaf extract, 10 parts of loquat leaf extract, 10 parts of oriental wormwood extract, 6 parts of microcos paniculata leaf extract, 6 parts of platycodon grandiflorum extract, 6 parts of figwort root extract, 15 parts of kudzu root extract, 4 parts of liquorice extract, 8 parts of wrinkled gianthyssop herb extract, 2 parts of medicated leaven, 10 parts of starch and 3 parts of magnesium stearate.
The preparation method of the traditional Chinese medicine composition for treating influenza comprises the following steps:
(1) according to the weight parts, taking 6 parts of mulberry leaf extract, 6 parts of perilla leaf extract, 10 parts of loquat leaf extract, 10 parts of oriental wormwood extract, 6 parts of microcos paniculata leaf extract, 6 parts of platycodon grandiflorum extract, 6 parts of figwort root extract, 15 parts of kudzu root extract, 4 parts of liquorice extract, 8 parts of wrinkled gianthyssop herb extract, 2 parts of medicated leaven and 10 parts of starch, stirring for 10min, and uniformly mixing;
(2) making into granules with a dry-process granulator, wherein the particle size of the prepared granules is 60 meshes;
(3) taking 3 parts of magnesium stearate, mixing with the granules prepared in the step (2), and filling into capsules, wherein the weight of each capsule is 0.2 g;
(4) and polishing, screening, internally packaging into bottles, externally packaging to obtain finished products, and warehousing after the finished products are qualified.
Example 3
A traditional Chinese medicine composition for treating influenza is prepared from the following substances in parts by weight: 12 parts of mulberry leaf extract, 12 parts of perilla leaf extract, 20 parts of loquat leaf extract, 20 parts of oriental wormwood extract, 12 parts of microcos paniculata leaf extract, 12 parts of platycodon grandiflorum extract, 12 parts of figwort root extract, 30 parts of kudzu root extract, 8 parts of liquorice extract, 12 parts of wrinkled gianthyssop herb extract, 6 parts of medicated leaven, 30 parts of starch and 8 parts of magnesium stearate.
The preparation method of the traditional Chinese medicine composition for treating influenza comprises the following steps:
(1) according to the weight parts, taking 12 parts of mulberry leaf extract, 12 parts of perilla leaf extract, 20 parts of loquat leaf extract, 20 parts of oriental wormwood extract, 12 parts of microcos paniculata leaf extract, 12 parts of platycodon grandiflorum extract, 12 parts of figwort root extract, 30 parts of kudzu root extract, 8 parts of liquorice extract, 12 parts of wrinkled gianthyssop herb extract, 6 parts of medicated leaven and 30 parts of starch, stirring for 30min, and uniformly mixing;
(2) making into granules with a dry-process granulator, wherein the particle size of the prepared granules is 100 meshes;
(3) taking 8 parts of magnesium stearate, mixing with the granules prepared in the step (2), and filling into capsules, wherein the weight of each capsule is 0.8 g;
(4) and polishing, screening, internally packaging into bottles, externally packaging to obtain finished products, and warehousing after the finished products are qualified.
Example 4
A traditional Chinese medicine composition for treating influenza is prepared from the following substances in parts by weight: 8 parts of mulberry leaf extract, 8 parts of perilla leaf extract, 15 parts of loquat leaf extract, 15 parts of oriental wormwood extract, 8 parts of microcos paniculata leaf extract, 8 parts of platycodon grandiflorum extract, 8 parts of figwort root extract, 20 parts of kudzu root extract, 6 parts of liquorice extract, 10 parts of wrinkled gianthyssop herb extract, 10 parts of delia schizonepeta extract, 4 parts of medicated leaven, 20 parts of starch and 5 parts of magnesium stearate.
The extraction method of the schizonepeta deliciosa extract comprises the following steps: drying herba Schizonepetae (Nepeta deflersiana Schweinf), grinding into powder, adding 8 times of 1% malic acid water solution, soaking for 4 days, filtering, recovering soaking solution, decolorizing with activated carbon, and evaporating to dryness.
The preparation method of the traditional Chinese medicine composition for treating influenza comprises the following steps:
(1) according to the weight parts, taking 8 parts of mulberry leaf extract, 8 parts of perilla leaf extract, 15 parts of loquat leaf extract, 15 parts of oriental wormwood extract, 8 parts of burdocks leaf extract, 8 parts of platycodon root extract, 8 parts of figwort root extract, 20 parts of kudzu root extract, 6 parts of liquorice extract, 10 parts of wrinkled gianthyssop herb extract, 4 parts of medicated leaven, 20 parts of starch and 10 parts of delier schizonepeta extract, stirring for 20min, and uniformly mixing;
(2) making into granules with a dry-process granulator, wherein the particle size of the prepared granules is 80 meshes;
(3) taking 5 parts of magnesium stearate, mixing with the granules prepared in the step (2), and filling into capsules, wherein the weight of each capsule is 0.5 g;
(4) and polishing, screening, internally packaging into bottles, externally packaging to obtain finished products, and warehousing after the finished products are qualified.
Example 5
A traditional Chinese medicine composition for treating influenza is prepared from the following substances in parts by weight: 8 parts of mulberry leaf extract, 8 parts of perilla leaf extract, 15 parts of loquat leaf extract, 15 parts of oriental wormwood extract, 8 parts of microcos paniculata leaf extract, 8 parts of platycodon grandiflorum extract, 8 parts of figwort root extract, 20 parts of kudzu root extract, 6 parts of liquorice extract, 10 parts of wrinkled gianthyssop herb extract, 10 parts of isostacia tenuifolia extract, 4 parts of medicated leaven, 20 parts of starch and 5 parts of magnesium stearate.
The extraction method of the schizonepeta heterochricosa extract comprises the following steps: drying herba Schizonepetae (Nepeta discor Benth.), grinding into powder, soaking in 8 times of 1% malic acid water solution for 4 days, filtering, recovering soaking solution, decolorizing with activated carbon, and evaporating to dryness.
The preparation method of the traditional Chinese medicine composition for treating influenza comprises the following steps:
(1) according to the weight parts, taking 8 parts of mulberry leaf extract, 8 parts of perilla leaf extract, 15 parts of loquat leaf extract, 15 parts of oriental wormwood extract, 8 parts of microcos paniculata leaf extract, 8 parts of platycodon grandiflorum extract, 8 parts of figwort root extract, 20 parts of kudzu root extract, 6 parts of liquorice extract, 10 parts of wrinkled gianthyssop herb extract, 4 parts of medicated leaven, 20 parts of starch and 10 parts of heterochrous schizonepeta extract, stirring for 20min, and uniformly mixing;
(2) making into granules with a dry-process granulator, wherein the particle size of the prepared granules is 80 meshes;
(3) taking 5 parts of magnesium stearate, mixing with the granules prepared in the step (2), and filling into capsules, wherein the weight of each capsule is 0.5 g;
(4) and polishing, screening, internally packaging into bottles, externally packaging to obtain finished products, and warehousing after the finished products are qualified.
Example 6
A traditional Chinese medicine composition for treating influenza is prepared from the following substances in parts by weight: 8 parts of mulberry leaf extract, 8 parts of perilla leaf extract, 15 parts of loquat leaf extract, 15 parts of oriental wormwood extract, 8 parts of microcos paniculata leaf extract, 8 parts of platycodon grandiflorum extract, 8 parts of figwort root extract, 20 parts of kudzu root extract, 6 parts of liquorice extract, 10 parts of wrinkled gianthyssop herb extract, 10 parts of tuber comfrey extract, 4 parts of medicated leaven, 20 parts of starch and 5 parts of magnesium stearate.
The extraction method of the tuber comfrey extract comprises the following steps: drying tuber comfrey (Symphytum tuberosum L.), grinding into powder, adding 8 times of 1% malic acid water solution, soaking for 4 days, filtering, recovering soaking solution, decolorizing with activated carbon, and evaporating to dryness.
The preparation method of the traditional Chinese medicine composition for treating influenza comprises the following steps:
(1) according to the weight parts, taking 8 parts of mulberry leaf extract, 8 parts of perilla leaf extract, 15 parts of loquat leaf extract, 15 parts of oriental wormwood extract, 8 parts of microcos paniculata leaf extract, 8 parts of platycodon grandiflorum extract, 8 parts of figwort root extract, 20 parts of kudzu root extract, 6 parts of liquorice extract, 10 parts of wrinkled gianthyssop herb extract, 4 parts of medicated leaven, 20 parts of starch and 10 parts of tuber comfrey extract, stirring for 20min, and uniformly mixing;
(2) making into granules with a dry-process granulator, wherein the particle size of the prepared granules is 80 meshes;
(3) taking 5 parts of magnesium stearate, mixing with the granules prepared in the step (2), and filling into capsules, wherein the weight of each capsule is 0.5 g;
(4) and polishing, screening, internally packaging into bottles, externally packaging to obtain finished products, and warehousing after the finished products are qualified.
Example 7
A traditional Chinese medicine composition for treating influenza is prepared from the following substances in parts by weight: 8 parts of mulberry leaf extract, 8 parts of perilla leaf extract, 15 parts of loquat leaf extract, 15 parts of oriental wormwood extract, 8 parts of microcos paniculata leaf extract, 8 parts of platycodon grandiflorum extract, 8 parts of figwort root extract, 20 parts of kudzu root extract, 6 parts of liquorice extract, 10 parts of wrinkled gianthyssop herb extract, 4 parts of medicated leaven, 20 parts of starch and 5 parts of magnesium stearate.
The preparation method of the traditional Chinese medicine composition for treating influenza comprises the following steps:
(1) according to the weight parts, taking 8 parts of mulberry leaf extract, 8 parts of perilla leaf extract, 15 parts of loquat leaf extract, 15 parts of oriental wormwood extract, 8 parts of microcos paniculata leaf extract, 8 parts of platycodon grandiflorum extract, 8 parts of figwort root extract, 20 parts of kudzu root extract, 6 parts of liquorice extract, 10 parts of wrinkled gianthyssop herb extract, 4 parts of medicated leaven and 20 parts of starch, stirring for 20min, and uniformly mixing;
(2) making into granules with a dry-process granulator, wherein the particle size of the prepared granules is 80 meshes;
(3) mixing 5 parts of magnesium stearate and 0.1 part of leucovorin with the granules prepared in the step (2), and filling capsules, wherein the capsule weight is 0.5g per granule;
(4) and polishing, screening, internally packaging into bottles, externally packaging to obtain finished products, and warehousing after the finished products are qualified.
Experimental example:
the symptoms of patients diagnosed with influenza are: acute onset of disease, hyperpyrexia, aversion to cold, headache, dizziness, general joint and muscle soreness, debilitation and other influenza symptoms. It is accompanied by respiratory symptoms such as pharyngalgia, watery nasal discharge, lacrimation, cough, etc.; in a few cases, there is anorexia accompanied by abdominal pain, abdominal distension, diarrhea, and vomiting.
For the selected cases meeting the above criteria, 225 patients were selected in the test, and the selected case samples were randomly divided into 5 groups of 45 persons each, and the pharmaceutical compositions of examples 1 and 4-7 were administered 1g daily for 6 days;
the disease curative effect judgment standard is as follows:
according to clinical symptoms and signs of influenza, a common symptom grading quantization table in <2000 years new Chinese medicine clinical research guiding principle > is referred, and symptom scores are drawn, wherein 0 score is calculated for asymptomatic symptoms, 1 score is calculated for mild symptoms, 2 scores is calculated for moderate symptoms, and 3 scores is calculated for severe symptoms.
And (3) healing: the bed symptoms and signs disappear, and the clinical observation score for restoring the hemogram to normal is reduced by more than 95 percent.
The method has the following advantages: the clinical symptoms and physical signs are improved, and the clinical observation integral is reduced by more than 70 percent.
And (4) invalidation: the clinical symptoms and signs are not obviously improved or even aggravated, and the clinical observation integral is reduced by less than 30 percent.
The results are shown in table 1:
| experimental group | Recovery method | Is effective | Invalidation | The total effective rate% |
| Example 1 | 27(60.0％) | 8(17.7％) | 10(22.2％) | 77.7％ |
| Example 4 | 32(71.1％) | 10(22.2％) | 3(6.7％) | 93.3％ |
| Example 5 | 26(57.7％) | 8(17.7％) | 11(24.4％) | 75.5％ |
| Example 6 | 33(73.3％) | 10(22.2％) | 2(4.4％) | 95.6％ |
| Example 7 | 32(71.1％) | 10(22.2％) | 3(6.7％) | 93.3％ |
As can be seen from table 1, the total effective rate of example 4 is significantly higher than that of example 1, and compared with example 1, the other experimental conditions are the same, only the addition of the schizonepeta deliciosa extract in example 4 proves that the schizonepeta deliciosa extract has the efficacy of treating influenza; example 5 the total effective rate of the schizonepeta discolor extract instead of the schizonepeta delavayi extract is equivalent to that of example 1, and the effect of the schizonepeta discolor extract on treating influenza is proved; the total effective rate of the example 6 is obviously higher than that of the example 1, compared with the example 1, other experimental conditions are the same, only the tuber comfrey extract is added in the example 6, and the effect of treating influenza is proved by the tuber comfrey extract; the total effective rate of example 7 is obviously higher than that of example 1, compared with example 1, other experimental conditions are the same, only the addition of more leukodermin in step 3 of example 7 proves that the leukodermin has the efficacy of treating influenza.
Claims (1)
1. The traditional Chinese medicine composition for treating influenza is characterized by being prepared from the following substances in parts by weight: 8 parts of mulberry leaf extract, 8 parts of perilla leaf extract, 15 parts of loquat leaf extract, 15 parts of oriental wormwood extract, 8 parts of microcos paniculata leaf extract, 8 parts of platycodon grandiflorum extract, 8 parts of figwort root extract, 20 parts of kudzu root extract, 6 parts of liquorice extract, 10 parts of wrinkled gianthyssop herb extract, 10 parts of delia schizonepeta extract, 4 parts of medicated leaven, 20 parts of starch and 5 parts of magnesium stearate;
the extraction method of the schizonepeta deliciosa extract comprises the following steps: drying herba Schizonepetae in the sun, grinding into powder, soaking in 8 times of 1% malic acid water solution for 4 days, filtering, recovering soaking solution, decolorizing with active carbon, and evaporating to dryness;
the preparation method of the traditional Chinese medicine composition for treating influenza comprises the following steps:
(1) according to the weight parts, taking 8 parts of mulberry leaf extract, 8 parts of perilla leaf extract, 15 parts of loquat leaf extract, 15 parts of oriental wormwood extract, 8 parts of burdocks leaf extract, 8 parts of platycodon root extract, 8 parts of figwort root extract, 20 parts of kudzu root extract, 6 parts of liquorice extract, 10 parts of wrinkled gianthyssop herb extract, 4 parts of medicated leaven, 20 parts of starch and 10 parts of delier schizonepeta extract, stirring for 20min, and uniformly mixing;
(2) making into granules with a dry-process granulator, wherein the particle size of the prepared granules is 80 meshes;
(3) taking 5 parts of magnesium stearate, mixing with the granules prepared in the step (2), and filling into capsules, wherein each capsule is 0.5 g;
(4) and polishing, screening, internally packaging into bottles, externally packaging to obtain finished products, and warehousing after the finished products are qualified.
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