CN108567898A - Treat cardiopathic Chinese medicine composition and preparation method thereof - Google Patents
Treat cardiopathic Chinese medicine composition and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to technical field of traditional Chinese medicine, it is specifically related to a kind for the treatment of cardiopathic Chinese medicine composition and preparation method thereof.The cardiopathic Chinese medicine composition for the treatment of of the present invention, including Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Ophiopogonis, radix paeoniae rubra, earthworm, radix scutellariae, glutinous rehmannia and the gardens stone Chang.The cardiopathic traditional Chinese medicine composition for treating effect of the treatment is good, and utilization rate of active components is high, has synergistic effect well between each raw material, safe without toxic side effect, cure rate is high, can be obviously improved cardiac function.Method is crushed using freezing broken wall to prepare so that medicinal material remains the effective ingredient of active compound significantly without the decoction of high temperature；Secondly it is crushed using wall-breaking machine so that intracellular active ingredient is fully utilized, and the dosage of Chinese medicine is greatly saved, increases drug effect.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine, be specifically related to it is a kind of treat cardiopathic Chinese medicine composition and its
Preparation method.
Background technology
Heart disease is a kind of common circulation system disease, and there are many specific disease.The circulatory system is by heart, blood vessel and adjusting
Sanguimotor neurohumor organizational composition, circulation system disease are also referred to as cardiovascular disease, common disease are belonged in internal disease, most
It is very harmful to be common.The cause of heart disease is complicated, and disease performance is varied, as rheumatic heart disease, congenital heart disease,
Hypertensive cardiopathy, coronary heart disease, myocarditis etc., heart disease have become in many diseases in China the highest disease of lethality it
One.And doctor trained in Western medicine has no specific treatment drug at present, although Western medicine short time interior energy plays the role of alleviation, Western medicine poison
Side effect is big, and curative effect is single, palliative, and somewhat expensive；Existing Chinese medicine composition narrow application range, in major part
Medicine is using the method decocted so that volatile materials volatilizees away in the event of high temperatures in Chinese medicine, utilization rate of active components
Low, therapeutic effect is bad.
Invention content
The purpose of the present invention is overcome the deficiencies of the prior art and provide a kind of to treat cardiopathic Chinese medicine composition.In this
Drug composition therapeutic effect is good, and utilization rate of active components is high, and there is synergistic effect well, safe and non-toxic pair to make between each raw material
With cure rate is high, can be obviously improved cardiac function；Invention also provides preparation methods.
The cardiopathic Chinese medicine composition for the treatment of of the present invention, including Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Ophiopogonis, radix paeoniae rubra, earthworm, radix scutellariae,
Glutinous rehmannia and the gardens stone Chang.
The cardiopathic Chinese medicine composition for the treatment of of the present invention, including Rhizoma Chuanxiong 0.5-0.8g, Radix Salviae Miltiorrhizae 0.5-15g, Radix Ophiopogonis
0.5-15g, radix paeoniae rubra 0.5-10g, earthworm 10-12g, radix scutellariae 5-20g, glutinous rehmannia 5-20g and stone Chang garden 5-30g.
Wherein：
The cardiopathic Chinese medicine composition for the treatment of of the present invention, further includes one kind in Radix Notoginseng, Radix Angelicae Sinensis or American Ginseng.
The cardiopathic Chinese medicine composition for the treatment of of the present invention, raw material composition are as follows：Rhizoma Chuanxiong 0.5-0.8g, Radix Salviae Miltiorrhizae 0.5-
15g, Radix Ophiopogonis 0.5-15g, radix paeoniae rubra 0.5-10g, earthworm 10-12g, radix scutellariae 5-20g, glutinous rehmannia 5-20g, stone Chang garden 5-30g and Radix Notoginseng
0.1-5g。
The cardiopathic Chinese medicine composition for the treatment of of the present invention, raw material composition are as follows：Rhizoma Chuanxiong 0.5-0.8g, Radix Salviae Miltiorrhizae 0.5-
15g, Radix Ophiopogonis 0.5-15g, radix paeoniae rubra 0.5-10g, earthworm 10-12g, radix scutellariae 5-20g, glutinous rehmannia 5-20g, stone Chang garden 5-30g and Radix Angelicae Sinensis
2-30g。
The cardiopathic Chinese medicine composition for the treatment of of the present invention, raw material composition are as follows：Rhizoma Chuanxiong 0.5-0.8g, Radix Salviae Miltiorrhizae 0.5-
15g, Radix Ophiopogonis 0.5-15g, radix paeoniae rubra 0.5-10g, earthworm 10-12g, radix scutellariae 5-20g, glutinous rehmannia 5-20g, stone Chang garden 5-30g and the West
Join 0.3-15g.
The preparation method of the cardiopathic Chinese medicine composition for the treatment of of the present invention crushes method using freezing broken wall and prepares；
Specifically include following steps：
(1) at a temperature of -4 DEG C -0 DEG C, bulk pharmaceutical chemicals are crushed to 200-400 mesh using wall-broken grinder；
(2) bulk pharmaceutical chemicals after above-mentioned crushing are mixed in proportion, capsule is prepared into according to traditional drug formulations method
Agent.
The cardiopathic Chinese medicine composition for the treatment of of the present invention is suitable for following therapeutic domain：Premature beat in heart disease,
Angina pectoris, is had palpitation at palpitaition；Headache, hypomnesia, inconvenient walking caused by cerebral embolism sequela；Antithrombus formation.
Medication is avoided：Cerebral hemorrhage, hypertensive patient use with caution；Avoid and is administered at empty stomach.
Dosage：Capsule preparations of the present invention are taken according to patient body weight situation：
Weight ＜ 50Kg 1-2/24 hours；
50Kg≤weight ＜ 100Kg 2/24 hours；
Weight >=100Kg 3/24 hours.
Freezing broken wall is carried out to rhizome of chuanxiong by using freezing broken wall comminuting method, make active ingredient ligustrazine therein, river diindyl,
Black table potash, ligustilide, caffeic acid, ferulic acid, Chrysophanol, choline chloride, cupreol and its a variety of volatile oil are released
It releases, and ensures that volatile oil is non-volatile.
Active ingredient in other bulk pharmaceutical chemicals in addition to rhizome of chuanxiong is made such as by using freezing broken wall comminuting method：Radix Notoginseng soap
Glycosides, ginsenoside, Radix Notoginseng R1-R7, Radix Notoginseng flavones, promoting blood circulation, hemostasis composition, trace element, ligustilide, cumarin, flavonoids
And the active ingredients such as phthalide analog compound evaporate.
Freezing broken wall comminuting method of the present invention is relative to existing decocting liquid, the concentration of decocting liquid film evaporation method or absorption
The methods of particle is made so that medicinal material remains the effective ingredient of active compound significantly without the decoction of high temperature, in particular so that former
Volatile important substance in medicinal material is preserved；Secondly being crushed using wall-breaking machine so that intracellular active ingredient
It is fully utilized, the dosage of Chinese medicine is greatly saved, increases drug effect.
The effect of cardiopathic Chinese medicine composition for the treatment of of the present invention prepares raw material is as follows：
Rhizoma Chuanxiong nature and flavor are acrid in flavour and warm in nature, and channel tropism enters liver, gallbladder channel；It is mainly used for promote breath and open depression, method wind-dryness is wet, promoting blood circulation and stopping pain；For the moon
Through uncomfortable, closed dysmenorrhea, lump in the abdomen abdominal pain, chest side of body shouting pain, tumbling and swelling, headache, arthralgia pain due to rheumatism.Radix Salviae Miltiorrhizae is bitter in taste, is slightly cold, the thoughts of returning home,
Liver Channel；It is inducing meastruation to relieve menalgia with promoting blood circulation, the effect of relieving restlessness that clears away heart-fire, cool blood to disappear carbuncle.Radix Ophiopogonis nature and flavor are sweet, and slight bitter is slightly cold, the thoughts of returning home,
Lung, stomach；For nourishing Yin and promoting production of body fluid, moisten the lung and relieve the cough；Few thirsty, the dry cough spitting of blood in Tianjin for lung-stomach yin deficiency；For insufficiency of heart yin it
The cards such as palpitation and being susceptible to fright and pyreticosis later stage heat consuming body fluid.Radix paeoniae rubra is bitter in taste, is slightly cold, return liver warp；With clearing heat and cooling blood, removing blood stasis and analgesics.
Earthworm has the effect of clearing heat for calming endogenous wind, clearing and activating the channels and collaterals, clearing lung, relieving asthma, reducing fever and causing diuresis.It is radix scutellariae bitter, cold in nature, there is heat-clearing and damp-drying drug, rush down
Fire removing toxic substances, hemostasis, tocolysis and other effects.Glutinous rehmannia nature and flavor are sweet, bitter, cold；The thoughts of returning home, liver and kidney channel；It enriches blood with enriching yin and nourishing kidney, blood-nourishing, is cool
The effect of blood.The gardens stone Chang slightly warm in nature, acrid flavour, hardship；Thoughts of returning home warp, stomach；Missing, town are reproduced with calm, anticonvulsion, improvement memory
Cough eliminating the phlegm, spasmolysis, antibacterial, anti-arrhythmia, the pharmacological actions such as reducing blood lipid, have one's ideas straightened out, is antitumor.Radix Notoginseng nature and flavor are sweet, slight bitter, temperature,
Return liver, stomach；Has the function of scattered blood analgesic therapy.Radix Angelicae Sinensis nature and flavor are sweet, pungent, warm, Return liver, the heart, the spleen channel；With enriching blood, invigorate blood circulation, menstruation regulating
The effect of analgesic, moisturize laxation.American Ginseng is cool in nature, sweet in flavor, slight bitter, has the effect of boosting qi and nourishing yin, clearing heat and promoting fluid.
Compared with prior art, the present invention having the advantages that：
(1) the cardiopathic traditional Chinese medicine composition for treating effect for the treatment of of the present invention is good, and utilization rate of active components is high, each raw material
Between have well that synergistic effect, safe without toxic side effect, cure rate are high, cardiac function can be obviously improved.
(2) the cardiopathic Chinese medicine composition for the treatment of of the present invention crushes method using freezing broken wall and prepares so that medicinal material
Without the decoction of high temperature, the effective ingredient of active compound is remained significantly；Secondly it is crushed using wall-breaking machine so that intracellular
Active ingredient is fully utilized, and the dosage of Chinese medicine is greatly saved, increases drug effect.
Specific implementation mode
The invention will be further described with reference to embodiments.
Embodiment 1
The cardiopathic Chinese medicine composition for the treatment of described in the present embodiment 1, raw material composition are as follows：Rhizoma Chuanxiong 0.5g, Radix Salviae Miltiorrhizae 2g, wheat
Winter 3g, radix paeoniae rubra 5g, earthworm 11g, radix scutellariae 8g, glutinous rehmannia 10g, stone Chang garden 15g.
The preparation method of the cardiopathic Chinese medicine composition for the treatment of described in the present embodiment 1 crushes legal system using freezing broken wall
It is standby；Specifically include following steps：
(1) at a temperature of -4 DEG C, bulk pharmaceutical chemicals are crushed to 250 mesh using wall-broken grinder；
(2) bulk pharmaceutical chemicals after above-mentioned crushing are mixed in proportion, capsule is prepared into according to traditional drug formulations method
Agent.
Meng, female, 69 years old now, weight 49Kg；It is diagnosed as within 2016 coronary heart disease, shows uncomfortable in chest, angina pectoris, is perspired, nothing
Power is had a back ache；Once the drugs such as used Radix Salviae Miltiorrhizae ball, inderal, Xinmaikang medicine；Controlling described in the present embodiment 1 is taken since in October, 2016
Treat cardiopathic Chinese medicine composition, 1/24 hours, until in April, 2018, symptom improved, normal ECG on inspection, all symptoms
It disappears.
Embodiment 2
The cardiopathic Chinese medicine composition for the treatment of described in the present embodiment 2, raw material composition are as follows：Rhizoma Chuanxiong 0.6g, Radix Salviae Miltiorrhizae 5g, wheat
Winter 3g, radix paeoniae rubra 4g, earthworm 12g, radix scutellariae 15g, glutinous rehmannia 15g, stone Chang garden 25g and Radix Notoginseng 1g.
Xue, man, 72 years old now, weight 65Kg；Find heart disease within 2016, angiocardiography is shown, heart anteposition coronary artery
Thrombosis at two, symptom are that lip is blue, uncomfortable in chest, angina, cannot lie low sleep, and in September, 2017 is taken described in the present embodiment 2
The cardiopathic Chinese medicine composition for the treatment of, 2/24 hours, take 3 months, constitutional symptom is obviously improved, asthma, purple lips phenomenon
It disappears, hospital checks, embolus still remains, and the state of an illness is steady, does not aggravate trend.
Embodiment 3
The cardiopathic Chinese medicine composition for the treatment of described in the present embodiment 3, raw material composition are as follows：Rhizoma Chuanxiong 0.8g, Radix Salviae Miltiorrhizae 10g,
Radix Ophiopogonis 10g, radix paeoniae rubra 7g, earthworm 10g, radix scutellariae 12g, glutinous rehmannia 15g, stone Chang garden 25g and Radix Angelicae Sinensis 5g.
Slowly certain, female, 71 years old now, weight 62Kg；Find coronary heart disease within 2015, electrocardiogram is shown, lower wave is low flat, right bundle branch
Block, sleeping, it is awake easily to suppress, and the heart twists pain, has a back ache；Danshen Root dropping ball, FUFANG DANSHEN WAN were once taken, takes this reality within 2016
Apply the cardiopathic Chinese medicine composition for the treatment of described in example 3,2/24 hours；It takes six months, symptom disappears, and does not recur.
Embodiment 4
The cardiopathic Chinese medicine composition for the treatment of described in the present embodiment 4, raw material composition are as follows：Rhizoma Chuanxiong 0.6g, Radix Salviae Miltiorrhizae 3g, wheat
Winter 10g, radix paeoniae rubra 7g, earthworm 12g, radix scutellariae 18g, glutinous rehmannia 15g, stone Chang garden 25g and American Ginseng 6g.
Wei, man, 39 years old now, weight 100Kg；Coronary heart disease is found within 2016, symptom is to sleep easily to suppress awake, heart strand pain,
It is uncomfortable in chest；Danshen Root dropping ball, FUFANG DANSHEN WAN were once taken, the cardiopathic Chinese medicine for the treatment of taken described in the present embodiment 4 for 2017
Composition, 3/24 hours；It takes six months, symptom disappears, and does not recur.
The cardiac 1000 that selection outpatient service is accepted for medical treatment takes the cardiopathic Chinese medicine composition for the treatment of of the present invention
After a period of time, improvement cardiovascular symptom is apparent, and effective percentage reaches 95%, and cure rate 70% does not find side effect.
Claims (7)
1. a kind for the treatment of cardiopathic Chinese medicine composition, it is characterised in that：Including Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Ophiopogonis, radix paeoniae rubra, earthworm, Huang
A kind of reed mentioned in ancient books, glutinous rehmannia and the gardens stone Chang.
2. the cardiopathic Chinese medicine composition for the treatment of according to claim 1, it is characterised in that：Rhizoma Chuanxiong 0.5-0.8g, Radix Salviae Miltiorrhizae
0.5-15g, Radix Ophiopogonis 0.5-15g, radix paeoniae rubra 0.5-10g, earthworm 10-12g, radix scutellariae 5-20g, glutinous rehmannia 5-20g and stone Chang garden 5-30g.
3. the cardiopathic Chinese medicine composition for the treatment of according to claim 1, it is characterised in that：Further include Radix Notoginseng, Radix Angelicae Sinensis or
One kind in American Ginseng.
4. the cardiopathic Chinese medicine composition for the treatment of according to claim 3, it is characterised in that：Raw material composition is as follows：Rhizoma Chuanxiong
0.5-0.8g, Radix Salviae Miltiorrhizae 0.5-15g, Radix Ophiopogonis 0.5-15g, radix paeoniae rubra 0.5-10g, earthworm 10-12g, radix scutellariae 5-20g, glutinous rehmannia 5-20g,
Stone Chang garden 5-30g and Radix Notoginseng 0.1-5g.
5. the cardiopathic Chinese medicine composition for the treatment of according to claim 3, it is characterised in that：Raw material composition is as follows：Rhizoma Chuanxiong
0.5-0.8g, Radix Salviae Miltiorrhizae 0.5-15g, Radix Ophiopogonis 0.5-15g, radix paeoniae rubra 0.5-10g, earthworm 10-12g, radix scutellariae 5-20g, glutinous rehmannia 5-20g,
Stone Chang garden 5-30g and Radix Angelicae Sinensis 2-30g.
6. the cardiopathic Chinese medicine composition for the treatment of according to claim 3, it is characterised in that：Raw material composition is as follows：Rhizoma Chuanxiong
0.5-0.8g, Radix Salviae Miltiorrhizae 0.5-15g, Radix Ophiopogonis 0.5-15g, radix paeoniae rubra 0.5-10g, earthworm 10-12g, radix scutellariae 5-20g, glutinous rehmannia 5-20g,
Stone Chang garden 5-30g and American Ginseng 0.3-15g.
7. the preparation method of the cardiopathic Chinese medicine composition for the treatment of described in a kind of claim 1 or 3, it is characterised in that：Using
It freezes broken wall and crushes method preparation；Specifically include following steps：
(1) at a temperature of -4 DEG C -0 DEG C, bulk pharmaceutical chemicals are crushed to 200-400 mesh using wall-broken grinder；
(2) bulk pharmaceutical chemicals after above-mentioned crushing are mixed in proportion, capsule is prepared into according to traditional drug formulations method.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810797425.8A CN108567898A (en) | 2018-07-19 | 2018-07-19 | Treat cardiopathic Chinese medicine composition and preparation method thereof |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201810797425.8A Pending CN108567898A (en) | 2018-07-19 | 2018-07-19 | Treat cardiopathic Chinese medicine composition and preparation method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1193528A (en) * | 1997-12-19 | 1998-09-23 | 刘世国 | Capsules for paralysis and preparation thereof |
| CN105597030A (en) * | 2016-03-08 | 2016-05-25 | 付守功 | Traditional Chinese medicine composition with functions of dispersing blood stasis and dredging vessels |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1193528A (en) * | 1997-12-19 | 1998-09-23 | 刘世国 | Capsules for paralysis and preparation thereof |
| CN105597030A (en) * | 2016-03-08 | 2016-05-25 | 付守功 | Traditional Chinese medicine composition with functions of dispersing blood stasis and dredging vessels |
Non-Patent Citations (1)
| Title |
|---|
| 李睿: "《第一次泡药茶就上手 第2版》", 30 November 2016, 哈尔滨出版社 * |
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Application publication date: 20180925 |