CN108562459B - Sampling device of bioreactor - Google Patents

Sampling device of bioreactor Download PDF

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Publication number
CN108562459B
CN108562459B CN201810228079.1A CN201810228079A CN108562459B CN 108562459 B CN108562459 B CN 108562459B CN 201810228079 A CN201810228079 A CN 201810228079A CN 108562459 B CN108562459 B CN 108562459B
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rod
bioreactor
sampling
driving
push
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CN108562459A (en
Inventor
骆中庚
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Ruan Bingxu
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Ruan Bingxu
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Publication of CN108562459A publication Critical patent/CN108562459A/en
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/02Devices for withdrawing samples
    • G01N1/10Devices for withdrawing samples in the liquid or fluent state
    • G01N1/14Suction devices, e.g. pumps; Ejector devices

Abstract

The invention discloses a sampling device of a bioreactor, which structurally comprises the bioreactor, a digital display screen, a pressure gauge, a control panel, a bottom plate seat, an automatic sampler, a support frame, a detention cylinder, a connecting pipe and a sample pipe, wherein the bioreactor is arranged on the right side above the bottom plate seat, the digital display screen is embedded on the upper part of the front surface of the bioreactor, the pressure gauge is arranged below the front surface of the bioreactor, the control panel is embedded below the front surface of the bioreactor and is positioned on the left side of the pressure gauge, the automatic sampler is arranged on the left side above the bottom plate seat and is communicated with the bioreactor through a connecting hose, the support frame is uniformly and equidistantly arranged above the automatic sampler, and the lower end of the support frame is vertically connected with the upper surface of the automatic sampler through threaded engagement. By arranging the automatic sampler, the invention can automatically start sampling after the bioreactor finishes reaction, and simultaneously recovers and converts kinetic energy during sampling into electric energy to provide electric energy for the prompting lamp, thereby effectively enhancing the automation performance of the sampling device of the bioreactor and being more humanized.

Description

Sampling device of bioreactor
Technical Field
The invention relates to a sampling device of a bioreactor, belonging to the field of bioreactors.
Background
Bioreactor refers to any manufacturing or engineering device that provides a biologically active environment. In one case, a bioreactor is a vessel that performs a chemical process involving the production of biologically or biochemically active substances from a particular organism. This process can be carried out either aerobically or anaerobically. These bioreactors are generally cylindrical, vary in volume from a few liters to several cubic meters, and are often made of stainless steel.
However, the sampling device of the bioreactor in the prior art has low automation degree, and the workload of workers is increased.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a sampling device of a bioreactor, which aims to overcome the defects that the automation degree of the sampling device of the bioreactor in the prior art is low and the workload of workers is increased.
In order to achieve the purpose, the invention is realized by the following technical scheme: a sampling device of a bioreactor structurally comprises a bioreactor, a digital display screen, a pressure gauge, a control panel, a bottom plate seat, an automatic sampler, a support frame, a detention cylinder, a connecting pipe and a sample tube, wherein the bioreactor is arranged on the right side above the bottom plate seat, the digital display screen is inlaid on the upper part of the front surface of the bioreactor, the pressure gauge is arranged below the front surface of the bioreactor, the control panel is inlaid below the front surface of the bioreactor and is positioned on the left side of the pressure gauge, the automatic sampler is arranged on the left side above the bottom plate seat and is communicated with the bioreactor through a connecting hose, the support frame is uniformly arranged above the automatic sampler at equal intervals, the lower end of the support frame is vertically connected with the upper surface of the automatic sampler through threaded engagement, the detention cylinder is arranged inside the support frame and is vertically connected with the upper end of the support frame through threaded engagement, and the lower end of the connecting pipe is, the upper end of the connecting pipe is communicated with the sample tube, the automatic sampler consists of an electromagnetic driving mechanism, a traction power connection mechanism, a motor driving mechanism, a push-pull sampling mechanism, a trapezoidal pipe, a one-way flow mechanism, a kinetic energy conversion electric energy mechanism, a sampling prompt lamp and a closed shell, the electromagnetic driving mechanism is arranged at the upper right corner of the closed shell and is electrically connected with the bioreactor, the traction power connection mechanism is arranged below the electromagnetic driving mechanism and is electrically connected with the motor driving mechanism, the push-pull sampling mechanism is arranged at the left side of the motor driving mechanism and is meshed and movably connected with the motor driving mechanism through a transmission belt, the trapezoidal pipe is obliquely arranged in the closed shell and is communicated with the closed shell through electric welding, the one-way flow mechanisms are two and are respectively arranged in the corners of the trapezoidal pipe, the kinetic energy conversion electric energy mechanism is arranged above the push-pull sampling mechanism and is meshed and movably connected, the sampling prompt lamp is embedded on the surface of the closed shell and is electrically connected with the kinetic energy conversion electric energy mechanism, and the closed shell is of a cylindrical structure and is connected with the upper surface of the baseplate seat through electric welding.
Further, electromagnetic drive mechanism comprises electro-magnet, pendulum rod, fixed plate, armature piece, last rack, first spring, spur gear, lower rack, second spring, the electro-magnet is inlayed in closed shell upper right corner inner wall, the pendulum rod is located electro-magnet left side below and is passed through hinge swing joint with the fixed plate, the armature piece is located the pendulum rod upper end and is binded the connection through glue, the lower extreme and the last rack of pendulum rod pass through hinge swing joint, go up the rack and locate the spur gear top and through teeth of a cogwheel meshing swing joint, rack right flank side and be connected through the electric welding on locating the first spring, the rack is located the spur gear below and is just connected through teeth of a cogwheel meshing swing joint down, the second spring is located rack left side and is connected through the electric welding.
Furthermore, the traction power connection mechanism comprises a wheel carrier, a traction swing rod, a hinge pivot, a sleeve ring, an arc rod, a third spring, a traction rope, a fixed pulley, a vertical slide rod, a lifting slider, a fourth spring, a limiting block and a power-moving end, wherein the traction swing rod is vertically arranged in the middle of the wheel carrier and movably connected with the hinge pivot, the sleeve ring is arranged at the lower end of the traction swing rod and is of an integrated forming structure, the sleeve ring is embedded on the outer surface of the arc rod and adopts clearance fit, the third spring is arranged at the right side of the sleeve ring and is connected with the right side of the sleeve ring through electric welding, one end of the traction rope is wound and connected with the upper end of the traction swing rod, the other end of the traction rope is wound and connected with the lifting slider by bypassing the fixed pulley, the lifting slider is sleeved on the outer surface of the vertical slide rod and adopts clearance fit, the fourth spring is arranged below the, the power end is arranged at the left side of the lifting slider and is electrically connected with the motor driving mechanism.
Furthermore, the motor driving mechanism consists of a driving motor, a motor base, an electrostatic end, a first transmission belt, a first transmission gear, a second transmission gear and a second transmission belt, the driving motor is arranged above the motor base and is connected with the motor base through electric welding, the driving motor is spirally connected with the inner wall of the closed shell through the motor base, the static end is arranged at the right side of the driving motor and is positioned right above the dynamic end, the first transmission belt is arranged between the driving motor and the first transmission gear and is meshed with the power output shaft of the driving motor and the wheel shaft of the first transmission gear in a movable connection, the second transmission gear is arranged at the left side of the first transmission gear and is movably connected through gear teeth in a meshing way, the second transmission belt is arranged between the second transmission gear and the push-pull sampling mechanism and is meshed and movably connected with a wheel shaft of the second transmission belt and a central shaft of the push-pull sampling mechanism.
Furthermore, the push-pull sampling mechanism comprises a rotating wheel, a fixed frame, a rotating push-pull rod, a push-pull block, a connecting rod, a slider, a sliding rod, a fixed pile, a welding block, a telescopic rod and an elastic sheet, wherein the rotating wheel is arranged above the fixed frame, the central shaft of the rotating wheel is movably connected with the fixed frame, the central shaft of the rotating wheel is meshed with one end of a second transmission belt and is movably connected with one end of the second transmission belt, one end of the rotating push-pull rod is movably connected with the edge of the front surface of the rotating wheel through a hinge, the other end of the rotating push-pull rod is movably connected with the push-pull block through a hinge, the upper end of the connecting rod is vertically connected with the push-pull block through electric welding, the slider is sleeved on the outer surface of the sliding rod and adopts clearance fit, the fixed piles are arranged at the two, one end of the telescopic rod is welded with the connecting rod through the welding block, and the other end of the telescopic rod is connected with the elastic sheet through glue in an adhesion mode.
Further, the flexure strip is located the interlude of trapezoidal pipe and is located between two one-way flow mechanisms, when the flexure strip is protruding form, the one-way flow mechanism that is located the top is the open mode, and the one-way flow mechanism that is located terminal is the closed mode, when the flexure strip is sunken form, the one-way flow mechanism that is located the top is the closed mode, and the one-way flow mechanism that is located terminal is the open mode.
Furthermore, the unidirectional flow mechanism is composed of a suspension bracket, an embedded rod, a connecting spring, a baffle, a brace and a base, wherein the embedded rod is arranged below the suspension bracket, the upper end of the embedded rod is embedded into the suspension bracket and is in sliding connection with the suspension bracket, the connecting spring is arranged below the suspension bracket, the upper end and the lower end of the connecting spring are respectively connected with the suspension bracket and the baffle through electric welding, the brace is arranged below the baffle, the upper end of the brace is connected with the baffle, and the lower end of the brace is movably connected with the base.
Further, kinetic energy conversion electric energy mechanism comprises third driving belt, belt pulley, fourth driving belt, drive wheel, cutting frame, S utmost point magnetic path, N utmost point magnetic path, rectifier, third driving belt one end and the center pin meshing swing joint of swiveling wheel, the third driving belt other end and the shaft meshing swing joint of belt pulley, fourth driving belt locates in the middle of belt pulley, the drive wheel and with shaft meshing swing joint, the drive wheel is located in the middle of cutting frame the place ahead and is connected through the electric welding, the cutting frame is located between S utmost point magnetic path and the N utmost point magnetic path, the rectifier is located N utmost point magnetic path left side and is connected with cutting frame electricity, the rectifier passes through the electric wire and is connected with sample warning light electricity.
Advantageous effects
The invention relates to a sampling device of a bioreactor, which realizes reaction through the bioreactor under the condition of connecting a power supply, after the reaction is finished, the bioreactor can send an electric signal to an electromagnet, the electromagnet is electrified to generate magnetic attraction armature block to drive the upper end of a swing rod to swing rightwards, the lower end of the swing rod swings leftwards and drives an upper rack to move leftwards, a spur gear is driven to rotate anticlockwise, a lower rack arranged below the spur gear can move rightwards and push the upper end of a traction swing rod to swing rightwards, the swing rod pulls one end of a traction rope, the other end of the traction rope bypasses a fixed pulley and pulls a lifting slider to slide along a vertical sliding rod and drive a movable end to move upwards and contact with a static end, the power supply of a driving motor is switched on, the driving motor starts to work and drives a first transmission gear to rotate through a first transmission belt, and the first transmission gear drives a second transmission gear to rotate through, the second transmission gear drives the rotating wheel to rotate through the second transmission belt, when the rotating wheel rotates one end of the rotating push-pull rod to the left side, the other end of the push-pull rod is rotated to drive the push-pull block, the connecting rod and the slider to slide leftwards along the sliding rod, and at the moment, when the telescopic rod welded with the connecting rod through the welding block pulls the elastic sheet to be convex, the one-way flow mechanism at the initial end is in an open state, the one-way flow mechanism at the tail end is in a closed state, the sample is sucked into the middle of the trapezoid tube from the start end of the trapezoid tube due to the air pressure, when the rotating wheel rotates one end of the rotating push-pull rod to the right side, the elastic sheet is concave, the one-way flow mechanism at the initial end is closed, the one-way flow mechanism at the tail end is in an open state, and a sample is extruded into the sample tube from the tail end of the trapezoid tube through the connecting tube due to air pressure, so that sampling is completed in a circulating mode; when the rotating wheel rotates, the third transmission belt drives the belt pulley to rotate, the belt pulley drives the driving wheel through the fourth transmission belt, the cutting frame welded with the driving wheel rotates rapidly along with the belt pulley, magnetic field lines existing between the S-pole magnetic block and the N-pole magnetic block are cut to generate electric energy, the electric energy is processed by the rectifier and then is transmitted to the sampling prompting lamp through an electric wire, and the sampling prompting lamp is turned on to prompt that the sampling state is achieved at the moment.
According to the sampling device of the bioreactor, the automatic sampler is arranged, so that the sampling can be automatically started after the bioreactor finishes the reaction, and meanwhile, the kinetic energy during the sampling is recycled and converted into the electric energy to provide the electric energy for the prompting lamp, so that the automation performance of the sampling device of the bioreactor is effectively enhanced, and the sampling device is humanized.
Drawings
Other features, objects and advantages of the invention will become more apparent upon reading of the detailed description of non-limiting embodiments with reference to the following drawings:
FIG. 1 is a schematic structural diagram of a sampling device of a bioreactor according to the present invention.
Fig. 2 is a plan view of an autosampler of the present invention.
Fig. 3 is a detailed structural diagram of an auto-sampler according to the present invention.
Fig. 4 is a diagram of the operation of an autosampler according to the present invention.
In the figure: bioreactor-1, digital display screen-2, pressure gauge-3, control panel-4, bottom plate seat-5, automatic sampler-6, support frame-7, detention cylinder-8, connecting pipe-9, sample pipe-10, electromagnetic driving mechanism-60, traction power connection mechanism-61, motor driving mechanism-62, push-pull sampling mechanism-63, ladder-64, one-way flow mechanism-65, kinetic energy conversion electric energy mechanism-66, sampling indicator lamp-67, closed shell-68, electromagnet-600, swing rod-601, fixed plate-602, armature block-603, upper rack-604, first spring-605, spur gear-606, lower rack-607, second spring-608, wheel carrier-610, 610, A traction swing rod-611, a hinge fulcrum-612, a lantern ring-613, an arc rod-614, a third spring-615, a traction rope-616, a fixed pulley-617, a vertical slide rod-618, a lifting slide-619, a fourth spring-6110, a limit block-6111, an electrokinetic end-6112, a driving motor-620, a motor base-621, an electrostatic end-622, a first driving belt-623, a first driving gear-624, a second driving gear-625, a second driving belt-626, a rotating wheel-630, a fixed frame-631, a rotating push-pull rod-632, a push-pull block-633, a connecting rod-634, a slide rod-635, a sliding rod-636, a fixed pile-637, a welding block-638, a telescopic rod-639, an elastic sheet-6310, a fixed pile-637, a welding block-, A hanging frame-650, an embedded rod-651, a connecting spring-652, a baffle-653, a brace-654, a base-655, a third driving belt-660, a belt pulley-661, a fourth driving belt-662, a driving wheel-663, a cutting frame-664, an S pole magnetic block-665, an N pole magnetic block-666 and a rectifier-667.
Detailed Description
In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the invention is further described with the specific embodiments.
Referring to fig. 1 to 4, the present invention provides a sampling device for a bioreactor, comprising: the structure of the device comprises a bioreactor 1, a digital display screen 2, a pressure gauge 3, a control panel 4, a bottom plate seat 5, an automatic sampler 6, a support frame 7, a detention cylinder 8, a connecting pipe 9 and a sample tube 10, wherein the bioreactor 1 is arranged on the right side above the bottom plate seat 5, the digital display screen 2 is inlaid on the upper part of the front surface of the bioreactor 1, the pressure gauge 3 is arranged below the front surface of the bioreactor 1, the control panel 4 is inlaid below the front surface of the bioreactor 1 and is positioned on the left side of the pressure gauge 3, the automatic sampler 6 is arranged on the left side above the bottom plate seat 5 and is communicated with the bioreactor 1 through a connecting hose, the support frame 7 is uniformly and equidistantly arranged above the automatic sampler 6, the lower end of the support frame is vertically connected with the upper surface of the automatic sampler 6 through thread engagement, the detention cylinder 8 is arranged inside the support frame 7 and is vertically connected with the upper end of the, the lower end of the connecting pipe 9 is vertically communicated with the detention cylinder 8, the upper end of the connecting pipe 9 is communicated with the sample tube 10, the automatic sampler 6 is composed of an electromagnetic driving mechanism 60, a traction power connection mechanism 61, a motor driving mechanism 62, a push-pull sampling mechanism 63, a trapezoidal pipe 64, a one-way flow mechanism 65, a kinetic energy conversion electric energy mechanism 66, a sampling indicator lamp 67 and a closed shell 68, the electromagnetic driving mechanism 60 is arranged at the right upper corner of the closed shell 68 and is electrically connected with the bioreactor 1, the traction power connection mechanism 61 is arranged below the electromagnetic driving mechanism 60, the traction power connection mechanism 61 is electrically connected with the motor driving mechanism 62, the push-pull sampling mechanism 63 is arranged at the left side of the motor driving mechanism 62 and is movably connected through a transmission belt in a meshing manner, the trapezoidal pipe 64 is obliquely arranged in the closed shell 68 and is electrically welded with the closed shell 68 in a communicated manner, the unidirectional flow mechanism 65 is provided with two unidirectional flow mechanisms which are respectively arranged inside the corners of the trapezoid tube 64, the kinetic energy conversion electric energy mechanism 66 is arranged above the push-pull sampling mechanism 63 and is movably connected with the push-pull sampling mechanism through a transmission belt in a meshing manner, the sampling indicator lamp 67 is embedded on the surface of the closed shell 68 and is electrically connected with the kinetic energy conversion electric energy mechanism 66, the closed shell 68 is in a cylindrical structure and is connected with the upper surface of the bottom plate seat 5 through electric welding, the electromagnetic driving mechanism 60 is composed of an electromagnet 600, a swing rod 601, a fixed plate 602, an armature block 603, an upper rack 604, a first spring 605, a spur gear 606, a lower rack 607 and a second spring 608, the electromagnet 600 is embedded on the inner wall of the right upper corner of the closed shell 68, the swing rod 601 is arranged below the electromagnet 600 and is movably connected with the fixed plate 602 through a hinge, the armature, the lower end of the swing rod 601 is movably connected with an upper rack 604 through a hinge, the upper rack 604 is arranged above a spur gear 606 and movably connected through gear teeth meshing, the first spring 605 is arranged on the right side of the upper rack 604 and connected through electric welding, the lower rack 607 is arranged below the spur gear 606 and movably connected through gear teeth meshing, the second spring 608 is arranged on the left side of the rack 607 and connected through electric welding, the traction power connection mechanism 61 is composed of a wheel carrier 610, a traction swing rod 611, a hinge fulcrum 612, a lantern ring 613, an arc rod 614, a third spring 615, a traction rope 616, a fixed pulley 617, a vertical sliding rod 618, a lifting slider 619, a fourth spring 6110, a limit block 6111 and a power-driven electric end 6112, the traction swing rod 611 is vertically arranged in the middle of the wheel carrier 610 and movably connected through the hinge fulcrum 612, the lantern ring 613 is arranged at the lower end of the traction swing rod 611, the lantern ring 613 is embedded on the outer surface of the arc wire rod 614 and is in clearance fit, the third spring 615 is arranged on the right side of the lantern ring 613 and is connected with the right side of the lantern ring 613 through electric welding, one end of the pulling rope 616 is connected with the upper end of the pulling swing rod 611 in a winding manner, the other end of the pulling rope 616 is connected with the lifting slider 619 in a winding manner by bypassing the fixed pulley 617, the lifting slider 619 is sleeved on the outer surface of the vertical sliding rod 618 and is in clearance fit, the fourth spring 6110 is arranged below the lifting slider 619 and is connected with the lifting slider 619 through electric welding, the limiting block 6111 is arranged on the middle and lower section of the vertical sliding rod 618 and is in an integrated molding structure with the vertical sliding rod 618, the power end 6112 is arranged on the left side of the lifting slider 619 and is electrically connected with the motor driving mechanism 62, the motor driving mechanism 62 is composed of a driving motor 620, a motor base 621, the driving motor 620 is arranged above the motor base 621 and connected through electric welding, the driving motor 620 is spirally connected with the inner wall of the closed shell 68 through the motor base 621, the electrostatic end 622 is arranged on the right side of the driving motor 620 and is positioned right above the dynamic-electric end 6112, the first transmission belt 623 is arranged between the driving motor 620 and the first transmission gear 624 and is meshed and movably connected with the power output shaft of the driving motor 620 and the wheel shaft of the first transmission gear 624, the second transmission gear 625 is arranged on the left side of the first transmission gear 624 and is meshed and movably connected through gear teeth, the second transmission belt 626 is arranged between the second transmission gear 625 and the push-pull sampling mechanism 63 and is meshed and movably connected with the wheel shaft of the second transmission belt 626 and the central shaft of the push-pull sampling mechanism 63, and the push-pull sampling mechanism 63 is meshed and movably connected with the rotating wheel 630, the fixing frame 631, the rotating rod, Connecting rod 634, slider 635, slide rod 636, spud pile 637, weld block 638, telescopic link 639, elastic sheet 6310 constitute, swiveling wheel 630 is located the mount 631 top, the center pin and the mount 631 swing joint of swiveling wheel 630, the center pin of swiveling wheel 630 and the one end meshing swing joint of second drive belt 626, rotatory push-pull rod 632 one end is through hinge and swiveling wheel 630 front surface edge swing joint, rotatory push-pull rod 632 other end is through hinge and push-pull block 633 swing joint, connecting rod 634 upper end and push-pull block 633 are through electric welding vertical connection, connecting rod 634 upper end is connected through electric welding 635 with slider 635, the slider overlaps in slide rod 636 surface and adopts clearance fit, spud pile 637 is located slide rod 636 both ends, slide rod 636 both ends pass through bolt spiral connection with spud pile 637, weld block 638 locates the middle-upper segment of connecting rod 634, one end of the telescopic rod 639 is welded to the connecting rod 634 through a welding block 638, the other end of the telescopic rod 639 is bonded to an elastic sheet 6310 through glue, the elastic sheet 6310 is disposed in the middle section of the trapezoid tube 64 and is located between the two unidirectional flow mechanisms 65, when the elastic sheet 6310 is convex, the unidirectional flow mechanism 65 located at the beginning is in an open state, and the unidirectional flow mechanism 65 located at the end is in a closed state, when the elastic sheet 6310 is concave, the unidirectional flow mechanism 65 located at the beginning is in a closed state, and the unidirectional flow mechanism 65 located at the end is in an open state, the unidirectional flow mechanism 65 is composed of a suspension frame 650, an embedded rod 651, a connecting spring 652, a baffle 653, a brace 654, and a base 655, the embedded rod 651 is disposed below the suspension frame 650, the upper end of the embedded rod 651 is embedded inside the suspension frame 650 and is slidably connected, the connecting spring 652 is disposed below the suspension frame 650, the upper and lower both ends of spring 652 that is connected are connected through the electric welding with mounted frame 650, baffle 653 respectively, brace 654 is located baffle 653 below and its upper end is connected with baffle 653, brace 654 lower extreme and base 655 swing joint, kinetic energy conversion electric energy mechanism 66 comprises third driving belt 660, belt pulley 661, fourth driving belt 662, drive wheel 663, cutting frame 664, S utmost point magnetic block 665, N utmost point magnetic block 666, rectifier 667, third driving belt 660 one end and the center pin meshing swing joint of swiveling wheel 630, the third driving belt 660 other end and the shaft meshing swing joint of belt pulley 661, fourth driving belt 662 is located in the middle of belt pulley 661, drive wheel 663 and with shaft meshing swing joint, drive wheel 663 is located in the middle of cutting frame 664 place ahead and is connected through the electric welding, cutting frame 664 is located between S utmost point magnetic block 665 and N utmost point magnetic block 666, rectifier 667 locates the left side of N utmost point magnetic path 666 and is connected with cutting frame 664 electricity, rectifier 667 is connected with sample warning light 67 electricity through the electric wire.
The invention relates to a sampling device of a bioreactor, which has the working principle that: under the condition of connecting a power supply, the bioreactor 1 realizes reaction, after the reaction is finished, the bioreactor 1 sends an electric signal to the electromagnet 600, the electromagnet 600 generates magnetism to attract the armature block 603 to drive the upper end of the oscillating bar 601 to swing rightwards, the lower end of the oscillating bar 601 swings leftwards and drives the upper rack 604 to move leftwards, the spur gear 606 is driven to rotate anticlockwise, meanwhile, the lower rack 607 arranged below the electromagnet 600 moves rightwards and pushes the upper end of the traction oscillating bar 611 to swing rightwards, the oscillating bar 611 pulls one end of the traction rope 616, the other end of the traction rope 616 passes through the fixed pulley 617, pulls the lifting slider 619 to slide along the vertical sliding bar 618 and drives the movable end 6112 to move upwards to contact with the static end 622, the power supply of the driving motor 620 is switched on, the driving motor 620 starts to work and drives the first transmission gear 624 to rotate through the first transmission belt 623, and the first transmission gear 624 drives the second transmission gear 625 to rotate through the gear, the second transmission gear 625 drives the rotation wheel 630 to rotate through the second transmission belt 626, when the rotation wheel 630 rotates one end of the rotation push-pull rod 632 to the left, the other end of the rotation push-pull rod 632 drives the push-pull block 633, the connection rod 634 and the slider 635 to slide leftwards along the sliding rod 636, at this time, the telescopic rod 639 welded to the connection rod 634 through the welding block 638 pulls the elastic sheet 6310 to be convex, the one-way flow mechanism 65 at the beginning is opened, the one-way flow mechanism 65 at the end is closed, the sample is sucked into the middle of the ladder-shaped tube 64 from the beginning of the ladder-shaped tube 64 due to the air pressure, when the rotation wheel 630 rotates one end of the rotation push-pull rod 632 to the right, the elastic sheet 6310 at this time is concave, the one-way flow mechanism 65 at the beginning is closed, the one-way flow mechanism 65 at the end is opened, the sample is squeezed into the sample tube 10 from the end of the ladder-shaped tube 64 through, the sampling is completed in such a cycle; when the rotating wheel 630 rotates, the third transmission belt 660 drives the belt pulley 661 to rotate, the belt pulley 661 drives the driving wheel 663 through the fourth transmission belt 662, the cutting frame 664 welded with the driving wheel 663 rotates rapidly, magnetic field lines existing between the S pole magnetic block 665 and the N pole magnetic block 666 are cut to generate electric energy, the electric energy is processed by the rectifier 667 and then is transmitted to the sampling prompting lamp 67 through an electric wire, and the sampling prompting lamp 67 is turned on to prompt that the sampling state is the sampling state at the moment.
The invention solves the problem that the sampling device of the bioreactor in the prior art has lower automation degree and increases the workload of workers, and can automatically start sampling after the bioreactor finishes reaction by combining the components and arranging the automatic sampler, and simultaneously recover and convert kinetic energy during sampling into electric energy to provide electric energy for the prompting lamp, thereby effectively enhancing the automation performance of the sampling device of the bioreactor and being more humanized.
While there have been shown and described what are at present considered the fundamental principles and essential features of the invention and its advantages, it will be apparent to those skilled in the art that the invention is not limited to the details of the foregoing exemplary embodiments, but is capable of other specific forms without departing from the spirit or essential characteristics thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.

Claims (1)

1. The utility model provides a bioreactor's sampling device, its structure includes bioreactor (1), digital display screen (2), manometer (3), controls panel (4), bottom plate seat (5), automatic sampler (6), support frame (7), is detained a section of thick bamboo (8), connecting pipe (9), sample cell (10), its characterized in that: the bioreactor (1) is arranged on the right side above the base plate seat (5), the digital display screen (2) is embedded on the upper part of the front surface of the bioreactor (1), the pressure gauge (3) is arranged below the front surface of the bioreactor (1), the control panel (4) is embedded below the front surface of the bioreactor (1) and is positioned on the left side of the pressure gauge (3), the automatic sampler (6) is arranged on the left side above the base plate seat (5) and is connected with the bioreactor (1) through a connecting hose, the support frame (7) is uniformly and equidistantly arranged above the automatic sampler (6) and the lower end of the support frame is vertically connected with the upper surface of the automatic sampler (6) through thread engagement, the detention cylinder (8) is arranged inside the support frame (7) and is vertically connected with the upper end of the support frame (7) through thread engagement, the lower end of the connecting pipe (9) and the detention cylinder (8) are vertically connected through a detention cylinder, the upper end of the connecting pipe (9) is communicated with the sample pipe (10); the automatic sampler (6) consists of an electromagnetic driving mechanism (60), a traction electricity connection mechanism (61), a motor driving mechanism (62), a push-pull sampling mechanism (63), a trapezoid tube (64), a one-way flow mechanism (65), a kinetic energy conversion electric energy mechanism (66), a sampling prompt lamp (67) and a closed shell (68), wherein the electromagnetic driving mechanism (60) is arranged at the right upper corner of the closed shell (68) and is electrically connected with the bioreactor (1), the traction electricity connection mechanism (61) is arranged below the electromagnetic driving mechanism (60), the traction electricity connection mechanism (61) is electrically connected with the motor driving mechanism (62), the push-pull sampling mechanism (63) is arranged at the left side of the motor driving mechanism (62) and is movably connected with the closed shell (68) through a transmission belt in a meshing manner, the trapezoid tube (64) is obliquely arranged in the closed shell (68) and is in through electric welding connection with the closed shell (68), the unidirectional flow mechanism (65) is provided with two unidirectional flow mechanisms which are respectively arranged inside the corners of the trapezoid tube (64), the kinetic energy conversion electric energy mechanism (66) is arranged above the push-pull sampling mechanism (63) and is movably connected with the push-pull sampling mechanism through a transmission belt in a meshing manner, the sampling prompt lamp (67) is embedded on the surface of the closed shell (68) and is electrically connected with the kinetic energy conversion electric energy mechanism (66), and the closed shell (68) is of a cylindrical structure and is connected with the upper surface of the bottom plate seat (5) through electric welding; the electromagnetic driving mechanism (60) comprises an electromagnet (600), a swing rod (601), a fixed plate (602), an armature block (603), an upper rack (604), a first spring (605), a spur gear (606), a lower rack (607) and a second spring (608), wherein the electromagnet (600) is embedded in the inner wall of the upper right corner of the closed shell (68), the swing rod (601) is arranged at the lower left of the electromagnet (600) and is movably connected with the fixed plate (602) through a hinge, the armature block (603) is arranged at the upper end of the swing rod (601) and is connected with the upper rack (604) through glue in an adhesive mode, the lower end of the swing rod (601) is movably connected with the upper rack (604) through the hinge, the upper rack (604) is arranged above the spur gear (606) and is movably connected with the upper rack through gear teeth meshing, the first spring (605) is arranged at the right side of the upper rack (604) and is connected with the upper rack (604) through electric welding, the lower, the second spring (608) is arranged on the left side of the rack (607) and is connected with the rack through electric welding; the traction power connection mechanism (61) comprises a wheel carrier (610), a traction swing rod (611), a hinge fulcrum (612), a sleeve ring (613), an arc rod (614), a third spring (615), a traction rope (616), a fixed pulley (617), a vertical sliding rod (618), a lifting slider (619), a fourth spring (6110), a limiting block (6111) and a power-moving end (6112), wherein the traction swing rod (611) is vertically arranged in the middle of the wheel carrier (610) and movably connected through the hinge fulcrum (612), the sleeve ring (613) is arranged at the lower end of the traction swing rod (611) and is of an integrally formed structure, the sleeve ring (613) is embedded in the outer surface of the arc rod (614) and is in clearance fit, the third spring (615) is arranged at the right side of the sleeve ring (613) and is connected through electric welding, one end of the traction rope (616) is connected with the upper end of the traction swing rod (611) in a winding manner, and the other end of the traction rope (616) is wound around, the lifting slider (619) is sleeved on the outer surface of the vertical sliding rod (618) and is in clearance fit, the fourth spring (6110) is arranged below the lifting slider (619) and is connected with the lifting slider (619) through electric welding, the limiting block (6111) is arranged at the middle-lower section of the vertical sliding rod (618) and is in an integrated forming structure with the vertical sliding rod (618), and the power-driven end (6112) is arranged at the left side of the lifting slider (619) and is electrically connected with the motor driving mechanism (62); the motor driving mechanism (62) is composed of a driving motor (620), a motor base (621), an electrostatic end (622), a first transmission belt (623), a first transmission gear (624), a second transmission gear (625) and a second transmission belt (626), the driving motor (620) is arranged above the motor base (621) and is connected with the motor base (621) through electric welding, the driving motor (620) is spirally connected with the inner wall of the closed shell (68) through the motor base (621), the electrostatic end (622) is arranged at the right side of the driving motor (620) and is positioned right above the dynamic end (6112), the first transmission belt (623) is arranged between the driving motor (620) and the first transmission gear (624) and is movably connected with the power output shaft of the driving motor (620) and the wheel shaft of the first transmission gear (624) in a meshing manner, the second transmission gear (625) is arranged at the left side of the first transmission gear (620) and is movably connected with the wheel teeth through 624 in a meshing manner, the second transmission belt (626) is arranged between the second transmission gear (625) and the push-pull sampling mechanism (63) and is in meshed movable connection with a wheel shaft of the second transmission belt (626) and a central shaft of the push-pull sampling mechanism (63); push-and-pull sampling mechanism (63) comprises swiveling wheel (630), mount (631), rotatory push-and-pull rod (632), push-and-pull block (633), connecting rod (634), slider (635), slide bar (636), spud pile (637), welding block (638), telescopic link (639), flexure strip (6310), mount (631) top is located to swiveling wheel (630), the center pin and mount (631) swing joint of swiveling wheel (630), the center pin of swiveling wheel (630) and the one end meshing swing joint of second driving belt (626), rotatory push-and-pull rod (632) one end is through hinge and swiveling wheel (630) front surface edge swing joint, rotatory push-and-pull rod (632) other end passes through hinge and push-and-pull block (633) swing joint, connecting rod (634) upper end is through the vertical connection of electric welding with push-and-pull block (633), connecting rod (634) upper end is connected through the electric welding with slider (635), the slider (635) is sleeved on the outer surface of the sliding rod (636) and is in clearance fit, the fixing piles (637) are arranged at two ends of the sliding rod (636), two ends of the sliding rod (636) are in threaded connection with the fixing piles (637) through bolts, the welding block (638) is arranged at the middle upper section of the connecting rod (634), one end of the telescopic rod (639) is welded with the connecting rod (634) through the welding block (638), and the other end of the telescopic rod (639) is bonded with the elastic sheet (6310) through glue; the elastic sheet (6310) is arranged at the middle section of the trapezoid pipe (64) and is positioned between the two unidirectional flow mechanisms (65), when the elastic sheet (6310) is in a convex shape, the unidirectional flow mechanism (65) positioned at the starting end is in an open state, the unidirectional flow mechanism (65) positioned at the tail end is in a closed state, when the elastic sheet (6310) is in a concave shape, the unidirectional flow mechanism (65) positioned at the starting end is in a closed state, and the unidirectional flow mechanism (65) positioned at the tail end is in an open state; the unidirectional flow mechanism (65) is composed of a suspension bracket (650), an embedded rod (651), a connecting spring (652), a baffle (653), a brace (654) and a base (655), the embedded rod (651) is arranged below the suspension bracket (650), the upper end of the embedded rod (651) is embedded into the suspension bracket (650) and is in sliding connection, the connecting spring (652) is arranged below the suspension bracket (650), the upper end and the lower end of the connecting spring (652) are respectively connected with the suspension bracket (650) and the baffle (653) through electric welding, the brace (654) is arranged below the baffle (653), the upper end of the brace (654) is connected with the baffle (653), and the lower end of the brace (654) is movably connected with the base (655); kinetic energy conversion electric energy mechanism (66) comprises third driving belt (660), belt pulley (661), fourth driving belt (662), drive wheel (663), cutting frame (664), S utmost point magnetic path (665), N utmost point magnetic path (666), rectifier (667), third driving belt (660) one end and the center pin engagement swing joint of swiveling wheel (630), the third driving belt (660) other end and the shaft engagement swing joint of belt pulley (661), fourth driving belt (662) are located in the middle of belt pulley (661), drive wheel (663) and with shaft engagement swing joint, drive wheel (663) are located in the middle of cutting frame (663) the place ahead and are connected through the electric welding, cutting frame (664) are located between S utmost point magnetic path (665) and N utmost point magnetic path (666), rectifier (667) are located N utmost point magnetic path (666) left side and are connected with cutting frame (664) electricity, the rectifier (667) is electrically connected with the sampling prompt lamp (67) through an electric wire.
CN201810228079.1A 2018-03-20 2018-03-20 Sampling device of bioreactor Active CN108562459B (en)

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Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2073512A1 (en) * 1990-11-13 1992-05-14 William G. Hungerford Automatic fluid sampling and monitoring apparatus and method
US5506791A (en) * 1989-12-22 1996-04-09 American Sigma, Inc. Multi-function flow monitoring apparatus with multiple flow sensor capability
CN201695039U (en) * 2010-06-06 2011-01-05 青岛众瑞智能仪器有限公司 System for monitoring pathogenic microorganism aerosol pollution groups
CN102279114A (en) * 2010-06-13 2011-12-14 王书梅 Structure of sampler
CN103018088A (en) * 2013-01-10 2013-04-03 武汉市康创科技有限公司 Fully-automatic liquid-based centrifugation and tableting machine
CN104214089A (en) * 2014-07-09 2014-12-17 何祥军 Novel magnetic gear pump
CN105748296A (en) * 2016-02-20 2016-07-13 廖淑梅 Permanent magnet sampling detection pharmaceutical device
CN206219583U (en) * 2016-11-17 2017-06-06 金宇保灵生物药品有限公司 Continuous sampling and state observation device in a kind of microcarrier cell digestion process

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5506791A (en) * 1989-12-22 1996-04-09 American Sigma, Inc. Multi-function flow monitoring apparatus with multiple flow sensor capability
CA2073512A1 (en) * 1990-11-13 1992-05-14 William G. Hungerford Automatic fluid sampling and monitoring apparatus and method
CN201695039U (en) * 2010-06-06 2011-01-05 青岛众瑞智能仪器有限公司 System for monitoring pathogenic microorganism aerosol pollution groups
CN102279114A (en) * 2010-06-13 2011-12-14 王书梅 Structure of sampler
CN103018088A (en) * 2013-01-10 2013-04-03 武汉市康创科技有限公司 Fully-automatic liquid-based centrifugation and tableting machine
CN104214089A (en) * 2014-07-09 2014-12-17 何祥军 Novel magnetic gear pump
CN105748296A (en) * 2016-02-20 2016-07-13 廖淑梅 Permanent magnet sampling detection pharmaceutical device
CN206219583U (en) * 2016-11-17 2017-06-06 金宇保灵生物药品有限公司 Continuous sampling and state observation device in a kind of microcarrier cell digestion process

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