CN108327241A - A kind of manufacturing method of controllable antibacterial trachea bracket - Google Patents
A kind of manufacturing method of controllable antibacterial trachea bracket Download PDFInfo
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- CN108327241A CN108327241A CN201810080520.6A CN201810080520A CN108327241A CN 108327241 A CN108327241 A CN 108327241A CN 201810080520 A CN201810080520 A CN 201810080520A CN 108327241 A CN108327241 A CN 108327241A
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- Prior art keywords
- antibacterial
- degradable
- trachea bracket
- manufacturing
- controllable
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- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 65
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 21
- 210000003437 trachea Anatomy 0.000 title claims description 70
- 239000000463 material Substances 0.000 claims abstract description 39
- 239000011159 matrix material Substances 0.000 claims abstract description 27
- 238000007639 printing Methods 0.000 claims abstract description 18
- 239000010410 layer Substances 0.000 claims description 36
- 230000003115 biocidal effect Effects 0.000 claims description 34
- 230000000845 anti-microbial effect Effects 0.000 claims description 30
- 239000000243 solution Substances 0.000 claims description 21
- 238000002156 mixing Methods 0.000 claims description 17
- 238000001125 extrusion Methods 0.000 claims description 14
- 230000002421 anti-septic effect Effects 0.000 claims description 12
- 108010010803 Gelatin Proteins 0.000 claims description 8
- 229920000159 gelatin Polymers 0.000 claims description 8
- 239000008273 gelatin Substances 0.000 claims description 8
- 235000019322 gelatine Nutrition 0.000 claims description 8
- 235000011852 gelatine desserts Nutrition 0.000 claims description 8
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 claims description 5
- 239000011259 mixed solution Substances 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 5
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- 238000006731 degradation reaction Methods 0.000 claims description 4
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 4
- 239000002356 single layer Substances 0.000 claims description 3
- 238000004381 surface treatment Methods 0.000 claims description 3
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 2
- 241000894006 Bacteria Species 0.000 claims description 2
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims description 2
- 229940072056 alginate Drugs 0.000 claims description 2
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- 238000004140 cleaning Methods 0.000 claims description 2
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 208000000059 Dyspnea Diseases 0.000 description 2
- 206010013975 Dyspnoeas Diseases 0.000 description 2
- 206010036790 Productive cough Diseases 0.000 description 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
- 238000003854 Surface Print Methods 0.000 description 2
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- 229910052751 metal Inorganic materials 0.000 description 2
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- 206010003598 Atelectasis Diseases 0.000 description 1
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- 208000004756 Respiratory Insufficiency Diseases 0.000 description 1
- 206010056397 Tracheomalacia Diseases 0.000 description 1
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- 230000036737 immune function Effects 0.000 description 1
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- 230000006872 improvement Effects 0.000 description 1
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- 238000009434 installation Methods 0.000 description 1
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
- B29C64/10—Processes of additive manufacturing
- B29C64/106—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
- B29C64/30—Auxiliary operations or equipment
- B29C64/386—Data acquisition or data processing for additive manufacturing
- B29C64/393—Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y10/00—Processes of additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y50/00—Data acquisition or data processing for additive manufacturing
- B33Y50/02—Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2240/001—Designing or manufacturing processes
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- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Materials Engineering (AREA)
- Manufacturing & Machinery (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Mechanical Engineering (AREA)
- Optics & Photonics (AREA)
- Biomedical Technology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
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Abstract
本发明公开了一种可控抗菌气管支架的制造方法，包括以下步骤：步骤一：配置抗菌溶液和生物相容可降解基质材料；步骤二：根据需求确定可降解抗菌层在气管支架基体表面的几何参数和抗菌成分浓度；步骤三、根据步骤二的几何参数和抗菌成分浓度计算打印路径和打印参数；步骤四、根据步骤三的打印路径和打印参数将可降解抗菌混合材料打印在气管支架基体表面；步骤五：将打印的可降解抗菌混合材料进行固化，可降解抗菌层固化成膜；本发明方法制造的气管支架置入人体后，随着可降解基质材料的逐渐降解逐渐释放出抗菌成分，通过控制抗菌成分浓度和抗菌层的几何参数控制抗菌成分的释放速率、浓度、抗菌时间等，使得置入后的气管支架实现可控的抗菌效果。
The invention discloses a method for manufacturing a controllable antibacterial tracheal stent, comprising the following steps: Step 1: configuring an antibacterial solution and a biocompatible degradable matrix material; Geometric parameters and antibacterial component concentration; step 3, calculate the printing path and printing parameters according to the geometric parameters and antibacterial component concentration in step 2; step 4, print the degradable antibacterial mixed material on the tracheal stent matrix according to the printing path and printing parameters in step 3 Surface; step 5: curing the printed degradable antibacterial mixed material, and curing the degradable antibacterial layer to form a film; after the tracheal stent manufactured by the method of the present invention is inserted into the human body, the antibacterial components are gradually released as the degradable matrix material gradually degrades By controlling the concentration of the antibacterial component and the geometric parameters of the antibacterial layer, the release rate, concentration, and antibacterial time of the antibacterial component are controlled, so that the implanted tracheal stent can achieve a controllable antibacterial effect.
Description
Technical field
The present invention relates to trachea bracket technical field, more particularly to a kind of manufacturing method of controllable antibacterial trachea bracket.
Background technology
Tracheae and bronchiostenosis can be caused by Different types of etiopathogenises, including：Inflammatory granuloma, wound, tracheomalacia, tumour
Deng.Tracheostenosis can cause obstructive pneumonia, atelectasis and expiratory dyspnea, serious to make patient that respiratory failure occur and jeopardize
Life.
Tracheal stent placing is one of the important means for the treatment of tracheostenosis, can release expiratory dyspnea rapidly.Improvement is faced
Bed symptom.Include clinically at present mainly metallic support and silicon stent etc. using more trachea bracket.Metal tracheae holder
Mostly be woven into netty circular tube shape using ti-ni shape memory alloy or stainless steel material, according to whether overlay film can be divided into again overlay film frame and
Bare bracket.Silicone trachea bracket can plant silicone material by medical grade and be made, and have two kinds of Y types and straight barrel type, it is possible to provide Duo Zhongzhi
Diameter and shape meet the needs of different patients, are removed compared to metallic support more convenient.
Extrusion molding biology 3D printing technique installs an extrusion axle additional in existing three axis 3D printing platforms, utilizes air pressure, work
The mode of plug or Screw Extrusion consolidates biomaterial extrusion molding while squeezing out using modes such as photocuring or cationic cures
Change sizing.
Trachea bracket can be placed in human body in short term or for a long time, clinical upper bracket merging after-poppet be in an open environment (with
Air is identical) in, the microorganism infection for being easy to be brought by respiratory movement does not have since rack surface does not have blood circulation yet
Cellular immune function, thus it is postoperative, and bacterium is easy to be colonized on holder and breeds and be difficult to clean off, gas after causing holder to place
Repeated infection in road, or even jeopardize patients ' lives..Therefore trachea bracket is improved, so that it is had antibacterial action has one
Fixed realistic meaning.In addition, different patient be placed in the period, implantation site the different demands for antibacterial coat also not to the utmost
It is identical.Therefore a kind of trachea bracket having controllable antibacterial coat is designed to have great importance.
Invention content
The present invention provides a kind of manufacturing methods of controllable antibacterial trachea bracket so that the trachea bracket realization after merging can
The antibacterial effect of control.
A kind of manufacturing method of controllable antibacterial trachea bracket, includes the following steps：
Step 1：Configure antiseptic solution and the degradable host material of bio-compatible；
Step 2：Geometric parameter and antimicrobial component of the determining degradable antibiotic layer in trachea bracket matrix surface according to demand
Concentration；
Step 3: calculating printing path and print parameters according to the geometric parameter of step 2 and antimicrobial component concentration；
Step 4: degradable antibacterial mixing material is printed upon rami tracheales according to the printing path of step 3 and print parameters
Frame matrix surface；
Step 5：The degradable antibacterial mixing material of printing is cured, degradable antibiotic layer film-forming.It is solidified into
The technique of film may be used sol-gal process and lead to after that is, antimicrobial component solution and the mixing of degradable host material are printed upon surface
It crosses drying means solvent (water or other solvents) volatilize, degradable matrix film is left, wherein being dispersed with antimicrobial component particle.
The present invention prints after being mixed antimicrobial component and the degradable host material of bio-compatible by way of 3D printing
Onto existing trachea bracket matrix, film-forming.After being placed in human body with trachea bracket afterwards, with degradable host material
Gradual degradation gradually release antimicrobial component, by control the geometric parameter control antibacterial of antimicrobial component concentration and antibiotic layer at
Rate of release, concentration, the antibacterial time etc. divided so that the trachea bracket after merging realizes controllable antibacterial effect.
Common trachea bracket not only may be implemented in the controllable antibacterial trachea bracket that the method proposed in through the invention obtains
Function, be also equipped with controllable antibacterial functions, degradable antibiotic layer can be designed according to the actual conditions of different patients, realized personalized
Customization.
Trachea bracket matrix described in step 3 is using clinically common silicone trachea bracket or metal tracheae holder.
Described in step 4 trachea bracket matrix surface printing before, trachea bracket matrix surface need to be cleared up.
The 3D platform print platforms used in step 4 are the biological 3D printing platforms of extrusion molding, and extrusion way can make
Air pressure extrusion, piston squeezes out or Screw Extrusion, squeezed out here using extruder pump in the form of piston etc..
The rheological equationm of state of the host material of bio-compatible is suitble to extrusion molding.Preferably, in step 1, use is twin-channel
Antiseptic solution and the degradable host material of bio-compatible are expressed into mixing tube and are sufficiently mixed rear extrusion molding by syringe pump.Bilateral
Two channels of road syringe pump can individually control the rate of extrusion in each channel, be used for while printing in control antibiotic layer
Antimicrobial component content.
The rheological equationm of state of the degradable host material of bio-compatible is suitble to extrusion molding, it is preferred that in step 1, the biology
Compatible degradable host material uses gelatin, methacrylate gelatin, chitosan, alginate and poly lactic-co-glycolic acid
At least one of copolymer.It is at least one refer to can be single ingredient, can also be several mixture.
In order to dissipate with more easily controlling antimicrobial component, it is preferred that in step 2, the degradable antibiotic layer is in tracheae
The geometric parameter on rest body surface includes shape and thickness.
In order to preferably coordinate the structure of trachea bracket, it is preferred that the shape is helical structure.Degradable antibiotic layer can
To use helical structure, the nail male structure of rack surface is avoided, while reducing the influence for expectoration.The geometric parameters of helical structure
Number further includes width and screw pitch.
Preferably, in step 1, the antiseptic solution is using antibiotic, sulfamido, imidazoles, nitro glyoxaline, quinoline promise
At least one of ketone, silver ion and nano-Ag particles.It is gradually released with the degradation of degradable host material after merging human body
It puts, plays antibacterial or antiinflammation.
Preferably, it in step 4, is surface-treated before trachea bracket matrix surface printing.Pass through certain table
Surface treatment improves the surface nature of rest body, is conducive to antiseptic solution and degradable matrix mixed solution adheres to.Mainly improve
Surface hydrophilicity, because silicone trachea bracket is hydrophobic material, and degradable host material is water wetted material, is not easy to adhere to.
Preferably, the surface treatment includes surface cleaning and surface hydrophilic processing.Such as plasma treatment or function dough
It is used for improving surface hydrophilicity Deng, plasma treatment, function dough is fixed using chemical bond using chemical grafting method
Water wetted material.
Preferably, the degradable antibiotic layer is single layer structure, and antimicrobial component content is squeezed by controlling antiseptic solution respectively
Go out and is adjusted with the rate of extrusion of the degradable host material of bio-compatible.Single layer structure, antimicrobial component content and thickness are adjustable.In addition
After antiseptic solution mixes printing with degradable host material, solvent therein vapors away after film-forming, be left antibacterial at
Divide and disperses in degradable host material.
Preferably, the antiseptic solution be Nano silver solution, the degradable host material of bio-compatible be chitosan and
Gelatin mixed solution.Nano silver has broad-spectrum sterilization effect, has no toxic and side effect to human body, not will produce drug dependence；Shell is poly-
Sugar and gelatin mixed solution, bio-compatible is degradable, and film forming and better mechanical property, this can be preferably played in conjunction with after
The advantages of invention.
Beneficial effects of the present invention：
The manufacturing method of the controllable antibacterial trachea bracket of the present invention is by way of printing by antimicrobial component and bio-compatible
It is printed on existing trachea bracket matrix after degradable host material mixing, antimicrobial component is placed in human body with trachea bracket
Afterwards, antimicrobial component gradually is released with the gradual degradation of degradable host material, by controlling antimicrobial component concentration and antibacterial
Rate of release, concentration, the antibacterial time etc. of the geometric parameter control antimicrobial component of layer so that the trachea bracket realization after merging can
The antibacterial effect of control.
Description of the drawings
Fig. 1 is the wire frame flow chart of the manufacturing method of the controllable antibacterial trachea bracket of the present invention.
Fig. 2 is the structural representation for the trachea bracket that the manufacturing method of the controllable antibacterial trachea bracket of the present invention manufactures
Figure.
Fig. 3 is the partial schematic sectional view for the controllable antibacterial trachea bracket that the method for the present invention manufactures.
Fig. 4 is the controllable antibacterial trachea bracket antibiotic layer partial schematic sectional view of the present invention.
Fig. 5 is the structural schematic diagram for the printing equipment that the method for the present invention uses.
Fig. 6 is the schematic cross-sectional view of the mixing tube of the antibiotic layer printing equipment of the present invention.
Each reference numeral is in figure：1. trachea bracket matrix, 2. degradable antibiotic layers, 3. silicone trachea brackets follow closely umbo
Structure, 4. degradable antibiotic layer screw pitch, 5. trachea bracket matrix outer diameters, 6. trachea bracket matrix internal diameters, 7. silicone trachea brackets nail
Convex height, 8. antibiotic layer width, the antimicrobial component in 9. antibiotic layers, 10. antibacterial layer thickness, 11. controllable antibacterial trachea brackets,
12. mixing tube, 13. trachea bracket axial rotation devices, 14. hold the syringe of the degradable host material of bio-compatible, and 15. contain
Put the syringe of the solution containing antimicrobial component, 16. binary channels syringe pumps, 17. mixing tube upper covers, 18. mixing pipe shells, 19. mixing
Pipe internal helical blades.
Specific implementation mode
As shown in Figure 1, the controllable antibacterial trachea bracket manufacturing method of the present embodiment, includes the following steps：
Step 1：Configure antiseptic solution (such as Nano silver solution) and the degradable host material of bio-compatible (such as shell gather
Sugar and gelatin mixed solution)；
Step 2：The geometric parameter and antimicrobial component concentration of degradable antibiotic layer are determined according to demand；
Step 3：Printing path and print parameters are calculated according to antibiotic layer geometric parameter and antimicrobial component concentration；
Step 4：According to calculated print parameters, degradable antibacterial mixing material is printed upon on 3D printing platform
Rest body surface；
Step 5：Make the degradable coat of the bio-compatible containing antibacterial granule after printing using certain curing mode
Film-forming.
As shown in Fig. 2, the controllable antibacterial trachea bracket that method through this embodiment manufactures, including：Trachea bracket
Matrix 1 and degradable antibiotic layer 2.Degradable antibiotic layer 2 is printed upon 1 appearance of trachea bracket by extruded type biology 3D printing platform
Face can not fall off or be permanently deformed as certain deformation occurs for trachea bracket matrix 1.
As shown in figure 3, the degradable antibiotic layer 2 that manufactures of the method for the present embodiment is in spiral shell in trachea bracket matrix surface
Shape is revolved, antibiotic layer width 8, the antimicrobial component 9 in antibiotic layer and the antibacterial layer thickness 10 of geometric parameter can be taking human as adjustings.It needs
To be illustrated, be herein schematic diagram, the dimension scale in figure does not represent the reality of degradable antibiotic layer 2 and trachea bracket matrix 1
Dimension scale, the actually thickness of degradable antibiotic layer 2 should be much smaller than the thickness of trachea bracket matrix 1.
As shown in Figure 4, be uniformly dispersed in the degradable antibiotic layer 2 that the method for the present embodiment manufactures antibacterial at
Point particle 6, only schematic diagram herein, in practice since the size of antimicrobial component particle 6 should in the micron-scale and hereinafter, antibacterial simultaneously
The shape of ingredient granules 6 may be irregular, it is understood that there may be local agglomeration.
As shown in Figure 5, the degradable antibiotic layer 2 that the method for the present embodiment manufactures can be printed by diagramatic way
It, can be around wherein controllable antibacterial trachea bracket 11 is mounted on trachea bracket axial rotation device 13 in trachea bracket matrix surface
Axial rotation, there are two syringes for installation on binary channels syringe pump 16, respectively hold the degradable host material of bio-compatible
Syringe 14 and the syringe 15 for holding the solution containing antimicrobial component can pass through the feed speed in 16 two channels of control syringe pump
The concentration of antimicrobial component in degradable antibiotic layer 2 is controlled, degradable host material is injected into mixed with the solution containing antimicrobial component
It closes in pipe 12, being sufficiently stirred two kinds of ingredients using helical blade in mixing tube 12 obtains uniform degradable antibacterial mixing material,
Mixing tube 12 is mounted in three-dimensional movement platform, can do three direction movements, cooperation trachea bracket axial rotation device 13 is in gas
Helical structure is printed on pipe holder matrix, avoids the nail male structure 3 on silicon stent surface, while reducing the shadow for expectoration
It rings, naturally it is also possible to print other shapes.
In conclusion the controllable antibacterial trachea bracket manufacturing method of the present embodiment, antibacterial is blended with by print platform
The degradable biological compatible material of ingredient is printed upon trachea bracket matrix surface, by film-forming, forms controllable antibiotic layer, leads to
The controlled release that antibacterial constituent concentration and geometric parameter in degradable antibiotic layer realize antimicrobial component is overregulated, it can be according to different trouble
The actual conditions of person design degradable antibiotic layer, personalized customization are realized, after effectively controllable solution trachea bracket merging
Infection problems.
Claims (10)
1. a kind of manufacturing method of controllable antibacterial trachea bracket, which is characterized in that include the following steps：
Step 1：Configure antiseptic solution and the degradable host material of bio-compatible；
Step 2：Determine that degradable antibiotic layer is dense in the geometric parameter and antimicrobial component of trachea bracket matrix surface according to demand
Degree；
Step 3: calculating printing path and print parameters according to the geometric parameter of step 2 and antimicrobial component concentration；
Step 4: degradable antibacterial mixing material is printed upon trachea bracket base according to the printing path of step 3 and print parameters
Body surface face；
Step 5：The degradable antibacterial mixing material of printing is cured, degradable antibiotic layer film-forming.
2. the manufacturing method of controllable antibacterial trachea bracket as described in claim 1, which is characterized in that in step 1, the life
The compatible degradable host material of object uses gelatin, methacrylate gelatin, chitosan, alginate and polylactic acid-glycolic base second
At least one of acid copolymer.
3. the manufacturing method of antibacterial trachea bracket as described in claim 1 controllable, which is characterized in that in step 2, it is described can
Degradation antimicrobial layer includes shape and thickness in the geometric parameter of trachea bracket matrix surface.
4. the manufacturing method of controllable antibacterial trachea bracket as claimed in claim 3, which is characterized in that the shape is spiral knot
Structure.
5. the manufacturing method of controllable antibacterial trachea bracket as described in claim 1, which is characterized in that described anti-in step 1
Bacterium solution uses in antibiotic, sulfamido, imidazoles, nitro glyoxaline, quinolones, silver ion and nano-Ag particles at least
It is a kind of.
6. the manufacturing method of controllable antibacterial trachea bracket as described in claim 1, which is characterized in that in step 4, described
It is surface-treated before the printing of trachea bracket matrix surface.
7. the manufacturing method of antibacterial trachea bracket as claimed in claim 6 controllable, which is characterized in that the surface treatment includes
Surface cleaning and surface hydrophilic processing.
8. the manufacturing method of controllable antibacterial trachea bracket as described in claim 1, which is characterized in that the degradable antibiotic layer
For single layer structure, antimicrobial component content is squeezed out by controlling antiseptic solution respectively and the extrusion of the degradable host material of bio-compatible
Rate adaptation.
9. the manufacturing method of controllable antibacterial trachea bracket as described in claim 1, which is characterized in that the antiseptic solution is to receive
The silver-colored solution of rice, the degradable host material of bio-compatible are chitosan and gelatin mixed solution.
10. the manufacturing method of controllable antibacterial trachea bracket as described in claim 1, which is characterized in that in step 1, using double
Antiseptic solution and the degradable host material of bio-compatible are expressed into after being sufficiently mixed in mixing tube and are extruded by the syringe pump in channel
Type.
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