CN108318672B - A kind of internal medicine and clinical laboratory's living body sampling analyzer - Google Patents
A kind of internal medicine and clinical laboratory's living body sampling analyzer Download PDFInfo
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- CN108318672B CN108318672B CN201810042682.0A CN201810042682A CN108318672B CN 108318672 B CN108318672 B CN 108318672B CN 201810042682 A CN201810042682 A CN 201810042682A CN 108318672 B CN108318672 B CN 108318672B
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- 238000005070 sampling Methods 0.000 title claims abstract description 79
- 239000003814 drug Substances 0.000 title claims abstract description 11
- 239000007788 liquid Substances 0.000 claims abstract description 69
- 239000007787 solid Substances 0.000 claims abstract description 56
- 238000001514 detection method Methods 0.000 claims abstract description 41
- 238000001727 in vivo Methods 0.000 claims abstract description 30
- 238000000605 extraction Methods 0.000 claims abstract description 17
- 238000007790 scraping Methods 0.000 claims abstract description 10
- 235000001674 Agaricus brunnescens Nutrition 0.000 claims abstract description 4
- 239000000835 fiber Substances 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 15
- 239000012530 fluid Substances 0.000 claims description 11
- 238000003384 imaging method Methods 0.000 claims description 11
- 238000012545 processing Methods 0.000 claims description 8
- 239000012491 analyte Substances 0.000 claims description 7
- 206010058109 Hangnail Diseases 0.000 claims description 5
- 238000006073 displacement reaction Methods 0.000 claims description 5
- 210000003781 tooth socket Anatomy 0.000 claims description 5
- 238000005119 centrifugation Methods 0.000 claims description 3
- 238000007689 inspection Methods 0.000 claims 1
- 239000000284 extract Substances 0.000 abstract description 15
- 230000001079 digestive effect Effects 0.000 abstract description 14
- 235000011389 fruit/vegetable juice Nutrition 0.000 abstract description 13
- 239000012634 fragment Substances 0.000 abstract description 5
- 235000013305 food Nutrition 0.000 abstract description 4
- 238000001574 biopsy Methods 0.000 description 19
- 210000004027 cell Anatomy 0.000 description 16
- 239000000126 substance Substances 0.000 description 9
- 238000006243 chemical reaction Methods 0.000 description 7
- 210000001035 gastrointestinal tract Anatomy 0.000 description 7
- 238000007789 sealing Methods 0.000 description 7
- 210000001519 tissue Anatomy 0.000 description 6
- 239000003054 catalyst Substances 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 230000029087 digestion Effects 0.000 description 3
- 210000004051 gastric juice Anatomy 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 210000001082 somatic cell Anatomy 0.000 description 3
- 230000008602 contraction Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000003365 glass fiber Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000011528 liquid biopsy Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 238000005192 partition Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 241000700605 Viruses Species 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 210000003463 organelle Anatomy 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 244000144985 peep Species 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 238000007781 pre-processing Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 208000018556 stomach disease Diseases 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
- A61B2010/0061—Alimentary tract secretions, e.g. biliary, gastric, intestinal, pancreatic secretions
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Surgery (AREA)
- Medical Informatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention discloses a kind of internal medicine and clinical laboratory's living body sampling analyzers, including in-vivo analysis case, it is equipped in in-vivo analysis case between solid detection between liquid detecting, in-vivo analysis box top is equipped with living sampling device, top, which is equipped with to be mounted on in-vivo analysis case by mounting rack, between liquid detecting takes liquid pump, sampler include across in-vivo analysis case top and with the connecting tube that takes liquid pump to connect, connecting tube top is connected with extraction hose, the end for extracting hose is provided with sampling block, the sampling block is equipped with opening up scraping slot in mushroom and sampling block bottom end, it is successively arranged circular hole from top to bottom in the sampling block, square mounting hole and arc groove, and circular hole, living body clamp device is inserted in square mounting hole and arc groove jointly.Sample block enter patient's alimentary canal after, can be accurately positioned, and sample block can also complete extract digestive juice, scrape take food or alimentary canal tapetum cell fragment, clamp sick cell or tissue etc. operate, it is convenient and efficient.
Description
Technical field
The present invention relates to the field of medical instrument technology, specially a kind of internal medicine and clinical laboratory's living body sampling analyzer.
Background technique
Gastroenterology patient is due to alimentary system problem, so that affecting body normally drains operation, in order to specific
The data for analyzing the various digestion liquid hold-ups of stomach, need to extract the mixtures such as patient's stomach digestive juice by equipment, then
Judge that stomach disease state, the prior art can only first pass through medical staff's sampling, analyzed, low efficiency by detecting
Under, increase the work difficulty of medical staff.
Application No. is a kind of gastroenterology living body sampling analytical equipments of 201710044051.8 disclosure of the invention, including shell
Body, the lower end of the shell are equipped with apocenosis passage, and the lower end of the apocenosis passage is equipped with liquid reserve tank, and the bottom of the liquid reserve tank is set
There is outlet tube, the outlet tube is equipped with the first valve, and the lateral wall of the shell is equipped with display screen, the upper end of the shell
Equipped with switch, the first attachment base and the second attachment base, through the first connecting tube is equipped on first attachment base, described first connects
The upper end of adapter tube is connected with sucking pump, and suction pipe is connected on the sucking pump, and the suction pipe is equipped with graduation mark, and the suction pipe is far from suction
One end of pump is equipped with sampling air bag, and the surface of the sampling air bag is equipped with through-hole and slot scraping, and the bottom of the slot scraping is equipped with volume
Slot, through being equipped with the second connecting tube on second attachment base.The present invention realizes sampling and analysis integration, does not have to medical care people
Member carries out cumbersome operation, time saving and energy saving, improves the working efficiency of medical staff.But the invention can only extract patient's alimentary canal
It is few to extract sample for interior digestive juice, and the invention peeps structure without interior, and sampling air bag empirically can only be goed deep into patient by doctor
In alimentary canal, it is easy to appear fault, to cause sampling spot inaccurate, to cause last result error biggish bad
Consequence.
Existing in-vivo analysis device has the following disadvantages and problem:
(1) can only detection and analysis digestive juice or active somatic cell, sample extraction amount is limited, and the result after detection simultaneously can not
It leans on, and it is slow to detect speed；
(2) living body detection device and living body extraction element are usually separated, this results in extracting living body extraction element
Biopsy samples put living body detection device into during can waste the plenty of time, be unfavorable for the quick judgement of patient's state of an illness；
(3) general living body extraction element is easy to pierce due to clamp device front end is excessively sharp after entering patient's alimentary canal
The alimentary canal of sick and wounded people, and general extraction element only has a kind of its function, for example, in pry through, living body clamping, extract gastric juice
Deng one of operation, if desired a variety of samples, then need the combination of a variety of different extraction elements, takes considerable time, and
Extend the pain of patient.
Summary of the invention
In order to overcome the shortcomings of prior art, the present invention provides a kind of internal medicine and clinical laboratory is analyzed with living body sampling
Device, the biopsy sample that can distinguish solid biopsy sample and liquid between solid detection between liquid detecting carries out analysis detection, living
Physical examination degree of testing the speed is fast, can extract digestive juice, scrape and take food or alimentary canal tapetum cell fragment, clamping sick cell or tissue, more
Approach extracts biopsy sample, and sampler small and exquisite exquisiteness from the patient, alleviates patient and is extracted during biopsy sample
Pain, can effectively solve background technique propose the problem of.
The technical solution adopted by the present invention to solve the technical problems is: a kind of internal medicine and clinical laboratory are analyzed with living body sampling
Device, including in-vivo analysis case, the in-vivo analysis case is interior to be equipped between solid detection between liquid detecting, in-vivo analysis case top
Portion is equipped with living sampling device, and top, which is equipped with to be mounted on in-vivo analysis case by mounting rack, between liquid detecting takes liquid pump,
It is described that liquid pump bottom end is taken to be connected with liquid sample transmitting pipe, it is equipped with and is located in liquid detecting below the fluid sample transmitting pipe
Solution process cartridge and fluid analyte meter positioned at solution process cartridge bottom end, the living sampling device includes across in-vivo analysis
Case top and with the connecting tube that takes liquid pump to connect, the connecting tube top is connected with extraction hose, sets in the end for extracting hose
Be equipped with sampling block, extract hose side be also connected with endoscope and image processing device it is characterized in that: the sampling block be in mushroom and
Sample block bottom end and be equipped with opening up scraping slot, be successively arranged in the sampling block from top to bottom circular hole, square mounting hole and
Arc groove, and living body clamp device is inserted in circular hole, square mounting hole and arc groove jointly.
As a preferred technical solution of the present invention, the living body clamp device includes being plugged in circular hole, rectangular respectively
Telescopic rod, the two-sided rack, two hemispherical Shell fixtures in mounting hole, arc groove, the telescopic rod bottom end and the two-sided rack are solid
Fixed connection, hemispherical Shell fixture one end are engaged by half gear with the two-sided rack.
As a preferred technical solution of the present invention, there are two half gear is set altogether, the left and right sides of the two-sided rack is designed with
Tooth socket, two and half gears are located at the left and right side of the two-sided rack and engage with the tooth socket of the two-sided rack left and right sides, described
Half gear and the two-sided rack can the upper and lower displacement in square mounting hole, the two-sided rack bottom end is fixed with crochet hook, the hook
Needle is equipped with several hangnails.
Further, it is inserted with wheel shaft at the center of half gear, is equipped with wheel shaft limit sliding chutes, the wheel shaft in sampling block
Both ends be plugged in wheel shaft limit sliding chutes, when half gear enters arc groove, the bottom side of wheel shaft and wheel shaft limit sliding chutes
Bottom end is affixed, and wheel shaft limit sliding chutes be displaced wheel shaft and half gear cannot still further below.
As a preferred technical solution of the present invention, the endoscope and image processing device include embedded in extract hose side and with sampling
The fiber hose of block connection, is equipped with several light guide bundles and image guide bundles in the fiber hose, the light guide bundles both ends are set respectively
There is light source, several light holes are equipped on sampling block, the light source of light guide bundles lower end is arranged in light hole.
As a preferred technical solution of the present invention, the sampling block is equipped with several imaging holes and connects with hose is extracted
Logical drawing liquid hole, the image guide bundles are inserted into imaging hole, and the image guide bundles top and bottom end are respectively equipped with and are mounted on fiber hose top
The eyepiece at end and the object lens being plugged in imaging hole.
Further, the top between solid detection is equipped with solid funnel, and the solid funnel is hinged with sealing cover,
Solid funnel bottom end is equipped with the centrifugal device between being located at solid detection and the Solids Analyzer immediately below centrifugal device,
The centrifugal device includes the rotating disk being mounted in solid detection by transverse slat, and the rotating disk top surface is fixedly installed with
Body sample collecting bottle, the solid sample collecting bottle top are hinged with seal bottle cap, the connection of solid sample collecting bottle bottom
There is sample flow pipe；
As a preferred technical solution of the present invention, between solid detection between liquid detecting between by sealing every
Plate separates, and is equipped with liquor box between the solid detection and in liquid detecting, the liquor box bottom end is connected with weeping pipe, institute
It states and solvent valve is installed on weeping pipe.
Compared with prior art, the beneficial effects of the present invention are:
(1) present invention links together In vivo detection case and living body extraction element, reduces and extracts living body to detection sample
The interlude of product, living body can be parsed out its ingredient faster, can distinguish solid work between liquid detecting between solid detection
The biopsy sample of body sample and liquid carries out analysis detection, and centrifugal device and agitating device make living body to the processing of biopsy sample
Sample reacts faster, accelerates the speed of in-vivo analysis and detection, keeps the result of detection relatively reliable；
(2) present invention is by the way that imaging hole, light hole, drawing liquid hole to be each provided on sampling block, and samples and be additionally provided with above block
Scraping slot is also equipped with living body clamp device in it, and sampling block can be accurately positioned after entering in patient's alimentary canal, and sampling
Block can also complete extract digestive juice, scrape take food or alimentary canal tapetum cell fragment, clamping sick cell or tissue etc. operation, make
The analysis sample of living body is more various, and analysis source is more, as a result more accurate, also more accurate to the judgement of patient's state of an illness；
(3) present invention is smaller into patient's sampling block in the digestive tract, extraction hose, fiber hose volume, special
Structure design make sample block will not injured patients alimentary canal, pain of patient when extracting biopsy sample can be mitigated.
Detailed description of the invention
Fig. 1 is overall structure diagram of the invention；
Fig. 2 is living sampling device structural schematic diagram of the invention；
Fig. 3 is living body clamp device structural schematic diagram of the invention.
In figure: 1- in-vivo analysis case；Between the detection of 2- solid；Between 3- liquid detecting；4- living sampling device；5- partition；6-
Liquor box；7- endoscope and image processing device；8- samples block；9- living body clamp device；
101- mounting rack；102- takes liquid pump；103- transverse slat；104- curet；
201- solid funnel；202- sealing cover；203- centrifugal device；204- rotating disk；205- solid sample collecting bottle；
206- sample flow pipe；207- Solids Analyzer；208- switch valve；209- bottle cap；
301- fluid sample transmitting pipe；If 302- solution process cartridge；303- agitating device；304- liquid line；305- control
Valve；306- fluid analyte meter；
401- connecting tube；402- extracts hose；403- drawing liquid hole；
601- weeping pipe；602- solvent valve；
701- fiber hose；702- light guide bundles；703- image guide bundles；704- light source；705- light hole；706- imaging hole；
707- eyepiece；708- object lens；
801- scrapes slot；802- circular hole；803- square mounting hole；804- arc groove；805- wheel shaft limiting slot；
901- telescopic rod；902- the two-sided rack；903- hemispherical Shell fixture；Half gear of 904-；905- crochet hook；906- hangnail；
907- wheel shaft.
Specific embodiment
As shown in Figure 1, the present invention provides a kind of internal medicine and clinical laboratory's living body sampling analyzer, for convenience of describing, under
It states cell, cell fragment etc. and is referred to as solid-state living body, and the substances such as blood plasma, digestive juice are referred to as liquid living body.Including living body point
Case 1 is analysed, is equipped in the in-vivo analysis case 1 between solid detection 3 between 2 and liquid detecting, is equipped at the top of the in-vivo analysis case 1
Living sampling device 4, between solid detection 3 between 2 and liquid detecting between separated by sealing partition 5, make solid-state living body
Analysis detection and the analysis detection of liquid living body are not interfere with each other.Between solid detection 3 between 2 and liquid detecting in be equipped with solution
Case 6, two liquor boxs 6 are interior to contain different reaction solution or catalyst, can accelerate the reaction of solid-state living body and liquid living body
Speed greatly speeds up the analysis speed of living body.6 bottom end of liquor box is connected with weeping pipe 601, on the weeping pipe 601
Solvent valve 602 is installed, the outflow or reservation of solution in liquor box 6 are controlled.
The solid funnel 201 being equipped at the top of the in-vivo analysis case 1 right above 2 between solid detection, solid-state living body
From solid funnel 201 into 2 between solid detection, the detection time of solid-state living body is shortened, it is convenient and efficient.The solid leakage
201 bottom ends struggle against equipped with 2 centrifugal device 203 and the Solids Analyzer immediately below centrifugal device 203 between solid detection
207, Solids Analyzer 207 can detect solid living body, such as cell, the swill organizing and be attached on alimentary canal inner wall
Chemical component, can have disease to alimentary canal patient provide a good etiological analysis foundation.
For convenience of the solid-state living body on living sampling device 4 is taken off, also connected by connecting line on solid funnel 201
There is curet 104, curet 104 is placed on when not used on in-vivo analysis case 1.When living sampling device 4 is in the alimentary canal of human body
When taking out solid-state living body, easily solid-state living body can be scraped in solid funnel 201 using curet 104, hence into solid
2 between detection, the analysis and detection of solid-state living body are facilitated.It is hinged with sealing cover 202 at the top of the solid funnel 201, to be checked
The solid-state living body of survey enters in the process finished between solid detection to detection, all covers sealing cover 202 in solid-state funnel 201,
Guarantee that the environment of experimental analysis is not contaminated, in-vivo analysis result is more acurrate.
The centrifugal device 203 includes the rotating disk 204 being mounted between solid detection in 2 by transverse slat 103, the rotation
204 top surface of disk is fixedly installed with solid sample collecting bottle 205, is hinged with bottle cap 209 at the top of the solid sample collecting bottle 205,
Bottle cap 209 can be when biopsy sample receives centrifugal force, and living body will not drop out solid sample collecting bottle 205.The solid-like
205 bottom of product collecting bottle is connected with sample flow pipe 206, and 206 bottom end of sample flow pipe extends on Solids Analyzer 207
Side, 206 top of sample flow pipe are equipped with switch valve 208, and switch valve 208 controls biopsy sample in solid collecting bottle 205
Outflow and do not flow out.
The step of upper section solid-state in-vivo analysis detects are as follows: first scrape down solid-state living body from sampling block 8, then from solid
Body drain bucket 201 is put into solid sample collecting bottle 205, and it is solid will to realize that ready reaction solution or catalyst are put into liquor box 6
In body sample collecting bottle 205, sealing cover 202 and bottle cap 209 are closed.Then starting rotating disk 204, which reaches rotating, makes
The speed of cell centrifugation, after cell is centrifuged, various substances are separated from each other, and make subsequent in-vivo analysis speed faster.At this moment
Turn on the switch valve 208, make centrifugation after living body solution from sample flow pipe 206 enter Solids Analyzer 207 in receive detection with
Analysis.
Centrifugal device 203 is that powerful centrifugal force is generated when rotating using objects at high speed according to centrifugal principle, makes to be placed in rotation
Sedimentation or floating occur for the suspended particulate in swivel, thus the purpose for making certain particles reach concentration or separate with other particles.
Here cell, organelle, virus and large biological molecule of suspended state etc. is sometimes referred as made in suspended particulate.Cell is centrifuged energy
It separates internal various structures and impurity mutually, keeps the detection of active somatic cell more simple and quick.
3 tops, which are equipped with to be mounted on in-vivo analysis case 1 by mounting rack 101, between the liquid detecting takes liquid pump 102, institute
It states and 102 bottom end of liquid pump is taken to be connected with liquid sample transmitting pipe 301, be equipped with below the fluid sample transmitting pipe 301 and be located at liquid
Solution process cartridge 302 in 3 between detection and the fluid analyte meter 306 positioned at 302 bottom end of solution process cartridge, the solution process cartridge
Agitating device 303 is inserted in 302, agitating device 303 makes liquid living body accelerate reaction, to accelerate the analysis of liquid living body
Detect speed.302 bottom end of solution process cartridge is connected with liquid line 304, and 304 bottom end of liquid line is equipped with fluid analyte meter
306, fluid analyte meter 306 can detect the chemical component and nutritional ingredient of the living body of the liquid such as patient's gastric juice, digestive juice, thus may be used
What kind of substance judgement lacks in patient body or lacks what kind of digestive ferment.Control valve 305 is installed on the liquid line 304, is opened
Control valve 305 can be such that liquid living body flows out out of solution process cartridge 302.
The step of upper section liquid In vivo detection are as follows: under the extraction for taking liquid pump 102, the liquid living body in the digestive tract of patient
Such as Gastric juice digestion liquid substance from living sampling device 4 enter liquid sample transmitting pipe 301 in after, be flowed into solution process cartridge
In 302.First determine that control valve 305 is closed state, is then added to the reaction solution prepared in liquor box 6 and catalyst etc.
Liquid in vivo, opens agitating device 303, and agitating device 303 accelerates liquid living body and sufficiently reacts, after completion of the reaction, beats
Open control valve 305, the biopsy sample of end of reaction from solution conduit 304 flow to fluid analyte meter 306 be inscribed it is examined, at this moment due to
The pre-processing of sample finishes, so greatly promoting the detection speed of liquid biopsy sample, has saved the time.
Here it should be noted that, above takes liquid pump 102 using micropump, has suction capacity, has and be not inserted into human body
Alimentary canal can draw the function of digestive juice, and micropump suction force is not very greatly, to make patient when being drawn digestive juice
It will not feel bad, alleviate the pain during patient is taken living body.
The living sampling device 4 include across 1 top of in-vivo analysis case and with the connecting tube 401 that takes liquid pump 102 to connect,
401 top of connecting tube, which is connected with, extracts hose 402, the end for extracting hose 402 is provided with sampling block 8, in sampling block 8
On be provided with several drawing liquid holes 403, extract hose 402 and connect with several drawing liquid holes 403 on sampling block 8, several drawing liquid holes
403 are uniformly distributed on the outer surface of sampling block 8, enable to extract the digestive juice that hose 402 extracts more direction, the sample taken
Capacity can be bigger.402 side of extraction hose is also connected with endoscope and image processing device 7.
Upper section extracts the step of patient's liquid biopsy sample are as follows: after filling in sampling block 8 in patient's alimentary canal, is peeped using interior
The position of the observation sampling block 8 of device 7 and the position of the block 8 of adjustment sampling at any time, make sampling block 8 reach patient in the digestive tract suitable
Behind position, unlatching takes liquid pump 102, and liquid pump 102 is taken to inhale patient's digestive juice in the digestive tract from drawing liquid hole 403 using pull of vacuum
To extracting in hose 402, subsequently into being tested and analyzed between liquid detecting 3.
As depicted in figs. 1 and 2, the endoscope and image processing device 7 includes connecting embedded in extraction 402 side of hose and with sampling block 8
Fiber hose 701 is equipped with several light guide bundles 702 and image guide bundles 703,702 both ends of light guide bundles in the fiber hose 701
Several light holes 705 for being respectively equipped with light source 704 and being located on sampling block 8, light source 704 are located at outside patient body, will not enter disease
In human body, patient safety is protected, the heat for avoiding light source enters in patient body to causing to burn in patient body.It is described to take
The drawing liquid hole 403 that sample block 8 is equipped with several imaging holes 706 and is connected to extraction hose 402, the insertion of image guide bundles 703 imaging
Hole 706,703 top of image guide bundles and bottom end are respectively equipped with the eyepiece 707 for being mounted on 701 top of fiber hose and are plugged in into
As the object lens 708 in hole 706.
Light guide bundles 702 and image guide bundles 703 are made of tens of thousands of glass fibres, and fiber is superfine, about the 1/10 of hair, soft
It is soft flexible.Every fiber conducts a luminous point, and the light head and the tail of the light glass whole marshalling in scope, both ends are right
It answers, all tens of thousands of a luminous points are from one end to the other end, if what is arranged between every fiber is closer, both ends are more neat, conduction
The brightness of image is bigger, and resolution ratio is higher, and image is more clear.So fiber hose 701 can be very thin, diameter is about 2-
4mm does not take up space, and it is small to go deep into the gastral hose overall volume of patient, reduces patient and is extracting hose 402 and fiber hose
701 feel bad sense into patient is gastral.
The working principle of upper section endoscope and image processing device 7 are as follows: after sampling block 8 enters patient's esophagus, the light that light source 704 issues exists
It is propagated in light guide bundles 702, irradiates and out of light hole 705, the substance near sampling block 8 can be illuminated, make to sample block 8 to living body
Sample rate faster, sample position it is more acurrate.
The sampling block 8 is equipped with opening up scraping slot 801 in mushroom and sampling 8 bottom end of block, reaches in sampling block 8
Behind some position, sampling block 8 can be made to move up and down, at this moment because of the special shape of sampling block 8, sample the corner angle of 8 side of block
Patient's some swills in the digestive tract or the substance separated with inner wall of the pipe are scraped off, the substance scraped off enters scraping
Then slot 801 pulls extraction hose 8 that sampling block 8 can be made to come out with scraping solid sample.
As shown in figure 3, it is recessed to be successively arranged circular hole 802, square mounting hole 803 and arc from top to bottom in the sampling block 8
Slot 804, and it is inserted with living body clamp device 9 jointly in circular hole 802, square mounting hole 803 and arc groove 804.The living body
Clamp device 9 includes being plugged in circular hole 802, square mounting hole 803, the telescopic rod 901 in arc groove 804, double cog respectively
902, two hemispherical Shell fixtures 903 of item, 901 bottom end of telescopic rod are fixedly connected with the two-sided rack 902, hemispherical Shell fixture 903
One end is engaged by half gear 904 with the two-sided rack 902, and telescopic rod 901 drives 902 upper and lower displacement of the two-sided rack, to make to press from both sides
Tool goes up and down and clamps biopsy sample.
The left and right sides of the two-sided rack 902 is designed with tooth socket, when 902 upper and lower displacement of the two-sided rack, hemispherical Shell is promoted to press from both sides
After tool 903 reaches suitable position, two and half gears 904 can all rotate to unclamp two hemispherical Shell fixtures 903, at this moment
Clamp patient's pathological tissues in the digestive tract, cell etc..One semi-area of outside of half gear 904 is equipped with continuous external tooth, energy
Make half gear 904 when non-rotary, since half gear 904 side with teeth is not contacted with the hole wall of square mounting hole 803,
The two-sided rack 902 can more easily control drive half gear 904 and hemispherical Shell fixture 903 to slide up and down in square mounting hole 803.
Half gear 904 described in two is located at the left and right side of the two-sided rack 902, and half gear, 904 center plugs
There is wheel shaft 907, is equipped with wheel shaft limit sliding chutes 805 in sampling block 8, the both ends of wheel shaft 907 are plugged in wheel shaft limit sliding chutes 805
It is interior, it ensure that the stability when stability of half gear 904 movement and hemispherical Shell fixture 903 clamp active somatic cell.In double cog
The end of item 902 is provided with crochet hook 905, and crochet hook 905 to be equipped with several hangnails 906, and hangnail 906 can be such that crochet hook 905 penetrates
Cell or tissue will not drop out, and improve the clamping success rate of biopsy sample.To guarantee that half gear 904 does not skid off arc groove
804 and make hemispherical Shell fixture 903 abjection control, before not clamping biopsy sample, contraction pole 901 is in contraction state, at this moment crochet hook
905 lower horizontal height is lower than the lower horizontal height of hemispherical Shell fixture 903, prevents sampling block 8 from entering patient's alimentary canal mistake
Patient is stabbed in journey.Half gear 904 and the upper and lower displacement in square mounting hole 803 of the two-sided rack 902.
The application clamps the step of biopsy sample are as follows: in the sampling arrival patient's alimentary canal of block 8 behind accurate sample position, stretches
Contracting bar 901 drives the decline elongation of the two-sided rack 902, at this moment since the gear teeth and hemispherical Shell fixture 903 of half gear 904 are by rectangular peace
The reason that is limited of dress hole 803, half gear 904 do not rotate, the band of half gear 904 and hemispherical Shell fixture 903 in the two-sided rack 902
To bottom offset, when half gear 904 enters arc groove 804, the bottom side of wheel shaft 907 and wheel shaft limit sliding chutes 805 under dynamic
Bottom end be affixed, wheel shaft limit sliding chutes 805 be displaced wheel shaft 907 and half gear 904 will not still further below.At this moment arc groove is permitted
Perhaps half gear 904 rotates, and the rotation of half gear 904 drives two 903 bottom ends of hemispherical Shell fixture to be separated from each other, and then crochet hook 905 exists
Sick cell or tissue are inserted under the movement of the two-sided rack 902.Then telescopic rod 901 drives the two-sided rack 902 to rise, and two
903 bottom end of hemispherical Shell fixture, which mutually closes up, clamps biopsy samples and to 803 contract of square mounting hole, and hemispherical Shell fixture 903 exists
It will not be unclamped in square mounting hole 803, and the design of crochet hook 905 makes biopsy sample completely be taken out of the alimentary canal of patient, takes out
Biopsy samples are reliable, and quality is kept.
It need to supplement, be shunk in telescopic rod 901 and the two-sided rack 902 is driven to rise, so that the two-sided rack 902 be made to drive
Hemispherical Shell fixture 903 is retracted in square mounting hole 803, after telescopic rod 901 is retracted to the limit, the bottom end water of hemispherical Shell fixture 903
It is higher than the lower horizontal height for sampling block 8 to equal height, entering sampling block 8, patient is gastral will not to accidentally injure digestion in the process
Road, it is safer, further the bottom face of hemispherical Shell fixture 903 can be set as arc surface, when clamping biopsy sample in this way, can reduced
The gastral risk of patient is stabbed in 903 bottom end of hemispherical Shell fixture, reduces the pain of patient.
Imaging hole 706, light hole 705, drawing liquid hole 403 are each provided on sampling block 8 by the present invention, and are sampled block 8 and gone back above
Equipped with scraping slot 801, living body clamp device 9 is also equipped in it, it is small that such design enters patient's sampling block 8 in the digestive tract
It is skilful exquisite, reduce the pain of patient.Block 8 is sampled after entering in patient's alimentary canal, can be accurately positioned, and sampling block 8 can also
Complete extract digestive juice, scrape take food or alimentary canal tapetum cell fragment, clamping sick cell or tissue operation, make living body
It is more various to analyze sample, analysis source is more, and it is as a result more accurate, it is also more accurate to the judgement of patient's state of an illness.
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie
In the case where without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power
Benefit requires rather than above description limits, it is intended that all by what is fallen within the meaning and scope of the equivalent elements of the claims
Variation is included within the present invention.Any reference signs in the claims should not be construed as limiting the involved claims.
Claims (4)
1. a kind of internal medicine and clinical laboratory's living body sampling analyzer, including in-vivo analysis case (1), in-vivo analysis case (1) is interior to be equipped with
It between solid detection between (2) and liquid detecting (3), is equipped with living sampling device (4) at the top of in-vivo analysis case (1), liquid inspection
(3) top, which is equipped with to be mounted on in-vivo analysis case (1) by mounting rack (101), between survey takes liquid pump (102), takes liquid pump (102)
Bottom end is connected with liquid sample transmitting pipe (301), is equipped between liquid detecting below fluid sample transmitting pipe (301) in (3)
Solution process cartridge (302) and be located at solution process cartridge (302) bottom end fluid analyte meter (306), sampler (4) include wear
Cross in-vivo analysis case (1) top and with the connecting tube (401) that takes liquid pump (102) to connect, connecting tube (401) top is connected with extraction
Hose (402) is provided with sampling block (8) in the end for extracting hose (402), is also connected in the side for extracting hose (402)
Endoscope and image processing device (7), it is characterised in that: the sampling block (8) is equipped with opening up scraping in mushroom and sampling block (8) bottom end
Slot (801), the sampling block (8) is interior to be successively arranged circular hole (802), square mounting hole (803) and arc groove from top to bottom
(804), it and in circular hole (802), square mounting hole (803) and arc groove (804) is inserted with living body clamp device (9) jointly,
The living body clamp device (9) includes being plugged in circular hole (802), square mounting hole (803) respectively, in arc groove (804)
Telescopic rod (901), the two-sided rack (902), two hemispherical Shell fixtures (903), telescopic rod (901) bottom end and the two-sided rack
(902) it is fixedly connected, described hemispherical Shell fixture (903) one end is engaged by half gear (904) with the two-sided rack (902), half tooth
There are two wheel (904) is set altogether, the left and right sides of the two-sided rack (902) is designed with tooth socket, and two and half gears (904) are located at two-sided
The left and right side of rack gear (902), and being engaged with the tooth socket of the two-sided rack (902) left and right sides, half gear (904) and two-sided
Rack gear (902) can be fixed with crochet hook in square mounting hole (803) interior upper and lower displacement, the two-sided rack (902) bottom end
(905), the crochet hook (905) is equipped with several hangnails (906), is inserted with wheel shaft (907), In at the center of half gear (904)
It samples in block (8) and is equipped with wheel shaft limit sliding chutes (805), the both ends of the wheel shaft (907) are plugged in wheel shaft limit sliding chutes (805)
It is interior, when half gear (904) enter arc groove (804), the bottom side of wheel shaft (907) and the bottom end of wheel shaft limit sliding chutes (805)
It is affixed, wheel shaft limit sliding chutes (805) be displaced wheel shaft (907) and half gear (904) cannot still further below.
2. a kind of internal medicine according to claim 1 and clinical laboratory's living body sampling analyzer, it is characterised in that: peeped in described
Device (7) includes embedded in the fiber hose (701) for extracting hose (402) side and connecting with sampling block (8), the fiber hose
(701) several light guide bundles (702) and image guide bundles (703) are installed in, light guide bundles (702) both ends are respectively equipped with light source
(704), several light holes (705) are equipped in sampling block (8), the light source of light guide bundles (702) lower end is arranged in light hole (705)
It is interior.
3. a kind of internal medicine according to claim 2 and clinical laboratory's living body sampling analyzer, it is characterised in that: the sampling
The drawing liquid hole (403) that block (8) is equipped with several imaging holes (706) and is connected to extraction hose (402), the image guide bundles (703)
It is inserted into imaging hole (706), image guide bundles (703) top and bottom end are respectively equipped with the mesh for being mounted on fiber hose (701) top
Mirror (707) and the object lens (708) being plugged in imaging hole (706).
4. a kind of internal medicine according to claim 1 and clinical laboratory's living body sampling analyzer, it is characterised in that: examined in solid
The top of (2) is equipped with solid funnel (201) between survey, the centrifugation of (2) between solid funnel (201) bottom end is equipped with and is located at solid detection
Device (203) and the Solids Analyzer (207) being located at below centrifugal device (203).
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| CN201810042682.0A CN108318672B (en) | 2018-01-17 | 2018-01-17 | A kind of internal medicine and clinical laboratory's living body sampling analyzer |
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| CN201810042682.0A CN108318672B (en) | 2018-01-17 | 2018-01-17 | A kind of internal medicine and clinical laboratory's living body sampling analyzer |
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| CN108318672B true CN108318672B (en) | 2019-12-03 |
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| CN109055357A (en) * | 2018-08-23 | 2018-12-21 | 李桂云 | A kind of new-type biological gene extracts instrument and application method |
| CN109770960A (en) * | 2019-03-12 | 2019-05-21 | 北京大学第三医院（北京大学第三临床医学院） | Bone biopsy needle |
| CN211433022U (en) * | 2019-12-17 | 2020-09-08 | 深圳市鸿美诊断技术有限公司 | Stomach helicobacter pylori sampling device |
| CN111743579B (en) * | 2020-07-07 | 2023-05-30 | 德阳市人民医院 | Infectious department protection type pathogen sample collection device |
| CN113331872B (en) * | 2021-05-25 | 2023-03-14 | 上海交通大学 | Miniature suction type alimentary canal multi-position liquid biopsy sampling device |
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| CN101650269A (en) * | 2009-09-07 | 2010-02-17 | 东南大学 | Wind-spring type expandable sampling rod |
| CN204725507U (en) * | 2015-06-08 | 2015-10-28 | 长沙瑞翔科技有限公司 | Jaw sampler |
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Effective date of registration: 20191106 Address after: No. 11, Xingyuan East Road, Zhangdian District, Zibo City, Shandong Province Applicant after: Liu Qingling Address before: 610041 Sichuan Province, Chengdu Tianfu Avenue, No. 69, No. 1720 building 17 layer 1 Applicant before: The general Science and Technology Ltd. of Chengdu Fes |
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