CN108283685A - Treat the Chinese medicine composition and preparation method thereof of chronic gastritis - Google Patents
Treat the Chinese medicine composition and preparation method thereof of chronic gastritis Download PDFInfo
- Publication number
- CN108283685A CN108283685A CN201810328491.0A CN201810328491A CN108283685A CN 108283685 A CN108283685 A CN 108283685A CN 201810328491 A CN201810328491 A CN 201810328491A CN 108283685 A CN108283685 A CN 108283685A
- Authority
- CN
- China
- Prior art keywords
- parts
- raw
- chinese medicine
- radix
- medicine composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000007882 Gastritis Diseases 0.000 title claims abstract description 67
- 239000003814 drug Substances 0.000 title claims abstract description 67
- 239000000203 mixture Substances 0.000 title claims abstract description 56
- 208000023652 chronic gastritis Diseases 0.000 title claims abstract description 42
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 241000287828 Gallus gallus Species 0.000 claims abstract description 40
- 235000010575 Pueraria lobata Nutrition 0.000 claims abstract description 39
- 244000046146 Pueraria lobata Species 0.000 claims abstract description 39
- 241000218989 Trichosanthes Species 0.000 claims abstract description 39
- 210000004317 gizzard Anatomy 0.000 claims abstract description 36
- 239000012528 membrane Substances 0.000 claims abstract description 36
- 240000006079 Schisandra chinensis Species 0.000 claims abstract description 29
- 235000008422 Schisandra chinensis Nutrition 0.000 claims abstract description 28
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims abstract description 16
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims abstract description 16
- 235000009685 Crataegus X maligna Nutrition 0.000 claims abstract description 16
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims abstract description 16
- 235000009486 Crataegus bullatus Nutrition 0.000 claims abstract description 16
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims abstract description 16
- 235000009682 Crataegus limnophila Nutrition 0.000 claims abstract description 16
- 235000004423 Crataegus monogyna Nutrition 0.000 claims abstract description 16
- 235000002313 Crataegus paludosa Nutrition 0.000 claims abstract description 16
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims abstract description 16
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000000126 substance Substances 0.000 claims abstract description 9
- 239000009636 Huang Qi Substances 0.000 claims description 32
- 241001092040 Crataegus Species 0.000 claims description 15
- 239000000706 filtrate Substances 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 229940079593 drug Drugs 0.000 claims description 8
- 238000000605 extraction Methods 0.000 claims description 8
- 238000010992 reflux Methods 0.000 claims description 8
- 239000008187 granular material Substances 0.000 claims description 4
- 239000003826 tablet Substances 0.000 claims description 3
- 239000007902 hard capsule Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 19
- 208000002193 Pain Diseases 0.000 abstract description 13
- 210000000952 spleen Anatomy 0.000 abstract description 13
- 210000001124 body fluid Anatomy 0.000 abstract description 8
- 239000010839 body fluid Substances 0.000 abstract description 8
- 210000004185 liver Anatomy 0.000 abstract description 8
- 238000004519 manufacturing process Methods 0.000 abstract description 8
- 231100000331 toxic Toxicity 0.000 abstract description 5
- 230000002588 toxic effect Effects 0.000 abstract description 5
- 230000002195 synergetic effect Effects 0.000 abstract description 4
- 230000001225 therapeutic effect Effects 0.000 abstract description 4
- 235000019789 appetite Nutrition 0.000 abstract description 3
- 230000036528 appetite Effects 0.000 abstract description 3
- 230000004936 stimulating effect Effects 0.000 abstract description 3
- 238000002560 therapeutic procedure Methods 0.000 abstract description 2
- 240000000171 Crataegus monogyna Species 0.000 abstract 1
- 235000013330 chicken meat Nutrition 0.000 description 30
- 210000004379 membrane Anatomy 0.000 description 27
- 210000002784 stomach Anatomy 0.000 description 21
- 208000024891 symptom Diseases 0.000 description 19
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 17
- 201000010099 disease Diseases 0.000 description 16
- 210000004072 lung Anatomy 0.000 description 14
- 235000019640 taste Nutrition 0.000 description 11
- 235000009508 confectionery Nutrition 0.000 description 8
- 230000007812 deficiency Effects 0.000 description 8
- 201000006549 dyspepsia Diseases 0.000 description 8
- 239000000796 flavoring agent Substances 0.000 description 8
- 230000003902 lesion Effects 0.000 description 8
- 206010011224 Cough Diseases 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 239000008280 blood Substances 0.000 description 7
- 230000006378 damage Effects 0.000 description 7
- 235000019634 flavors Nutrition 0.000 description 7
- 239000000843 powder Substances 0.000 description 7
- 230000035922 thirst Effects 0.000 description 7
- 206010061218 Inflammation Diseases 0.000 description 6
- 210000004907 gland Anatomy 0.000 description 6
- 230000004054 inflammatory process Effects 0.000 description 6
- 206010012735 Diarrhoea Diseases 0.000 description 5
- 210000001015 abdomen Anatomy 0.000 description 5
- 208000001848 dysentery Diseases 0.000 description 5
- 208000015181 infectious disease Diseases 0.000 description 5
- 210000003734 kidney Anatomy 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 241000227129 Aconitum Species 0.000 description 4
- 208000019901 Anxiety disease Diseases 0.000 description 4
- 241000756943 Codonopsis Species 0.000 description 4
- 206010054949 Metaplasia Diseases 0.000 description 4
- 244000197580 Poria cocos Species 0.000 description 4
- 235000008599 Poria cocos Nutrition 0.000 description 4
- 230000004596 appetite loss Effects 0.000 description 4
- 239000002775 capsule Substances 0.000 description 4
- 230000001684 chronic effect Effects 0.000 description 4
- 208000037976 chronic inflammation Diseases 0.000 description 4
- 230000006020 chronic inflammation Effects 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 208000019017 loss of appetite Diseases 0.000 description 4
- 235000021266 loss of appetite Nutrition 0.000 description 4
- 206010025482 malaise Diseases 0.000 description 4
- 230000015689 metaplastic ossification Effects 0.000 description 4
- 210000004400 mucous membrane Anatomy 0.000 description 4
- 230000001717 pathogenic effect Effects 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 208000004998 Abdominal Pain Diseases 0.000 description 3
- 206010003694 Atrophy Diseases 0.000 description 3
- 206010010774 Constipation Diseases 0.000 description 3
- 206010019375 Helicobacter infections Diseases 0.000 description 3
- 241000590002 Helicobacter pylori Species 0.000 description 3
- 206010037660 Pyrexia Diseases 0.000 description 3
- 244000272264 Saussurea lappa Species 0.000 description 3
- 235000006784 Saussurea lappa Nutrition 0.000 description 3
- 230000037444 atrophy Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 238000003759 clinical diagnosis Methods 0.000 description 3
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 210000000981 epithelium Anatomy 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 210000001156 gastric mucosa Anatomy 0.000 description 3
- 229940037467 helicobacter pylori Drugs 0.000 description 3
- 230000001965 increasing effect Effects 0.000 description 3
- 230000008595 infiltration Effects 0.000 description 3
- 238000001764 infiltration Methods 0.000 description 3
- 210000000936 intestine Anatomy 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 210000000440 neutrophil Anatomy 0.000 description 3
- 238000010791 quenching Methods 0.000 description 3
- 230000002269 spontaneous effect Effects 0.000 description 3
- 208000011580 syndromic disease Diseases 0.000 description 3
- 206010000087 Abdominal pain upper Diseases 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 206010007247 Carbuncle Diseases 0.000 description 2
- 241000218176 Corydalis Species 0.000 description 2
- 241000657480 Crataegus pinnatifida Species 0.000 description 2
- 229920001353 Dextrin Polymers 0.000 description 2
- 239000004375 Dextrin Substances 0.000 description 2
- 206010013786 Dry skin Diseases 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 2
- 206010028116 Mucosal inflammation Diseases 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 2
- 244000248557 Ophiopogon japonicus Species 0.000 description 2
- 241001522129 Pinellia Species 0.000 description 2
- 241000219780 Pueraria Species 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- PJANXHGTPQOBST-VAWYXSNFSA-N Stilbene Natural products C=1C=CC=CC=1/C=C/C1=CC=CC=C1 PJANXHGTPQOBST-VAWYXSNFSA-N 0.000 description 2
- 244000078912 Trichosanthes cucumerina Species 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 244000273928 Zingiber officinale Species 0.000 description 2
- 235000006886 Zingiber officinale Nutrition 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 208000007502 anemia Diseases 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 208000035850 clinical syndrome Diseases 0.000 description 2
- 235000019425 dextrin Nutrition 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 208000010643 digestive system disease Diseases 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 2
- 206010013023 diphtheria Diseases 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 208000017574 dry cough Diseases 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 235000019525 fullness Nutrition 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 235000008397 ginger Nutrition 0.000 description 2
- 206010020718 hyperplasia Diseases 0.000 description 2
- 210000004347 intestinal mucosa Anatomy 0.000 description 2
- 235000021374 legumes Nutrition 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 235000013372 meat Nutrition 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 2
- 239000008108 microcrystalline cellulose Substances 0.000 description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 description 2
- 230000036565 night sweats Effects 0.000 description 2
- 206010029410 night sweats Diseases 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- 206010036067 polydipsia Diseases 0.000 description 2
- 230000000291 postprandial effect Effects 0.000 description 2
- 210000001187 pylorus Anatomy 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000011122 softwood Substances 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical compound C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 description 2
- 235000021286 stilbenes Nutrition 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- XFSBVAOIAHNAPC-XTHSEXKGSA-N 16-Ethyl-1alpha,6alpha,19beta-trimethoxy-4-(methoxymethyl)-aconitane-3alpha,8,10alpha,11,18alpha-pentol, 8-acetate 10-benzoate Chemical compound O([C@H]1[C@]2(O)C[C@H]3[C@@]45C6[C@@H]([C@@]([C@H]31)(OC(C)=O)[C@@H](O)[C@@H]2OC)[C@H](OC)[C@@H]4[C@]([C@@H](C[C@@H]5OC)O)(COC)CN6CC)C(=O)C1=CC=CC=C1 XFSBVAOIAHNAPC-XTHSEXKGSA-N 0.000 description 1
- MCSXGCZMEPXKIW-UHFFFAOYSA-N 3-hydroxy-4-[(4-methyl-2-nitrophenyl)diazenyl]-N-(3-nitrophenyl)naphthalene-2-carboxamide Chemical compound Cc1ccc(N=Nc2c(O)c(cc3ccccc23)C(=O)Nc2cccc(c2)[N+]([O-])=O)c(c1)[N+]([O-])=O MCSXGCZMEPXKIW-UHFFFAOYSA-N 0.000 description 1
- XFSBVAOIAHNAPC-UHFFFAOYSA-N Aconitin Natural products CCN1CC(C(CC2OC)O)(COC)C3C(OC)C(C(C45)(OC(C)=O)C(O)C6OC)C1C32C4CC6(O)C5OC(=O)C1=CC=CC=C1 XFSBVAOIAHNAPC-UHFFFAOYSA-N 0.000 description 1
- 241000553739 Aconitum carmichaelii var. truppelianum Species 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 240000004510 Agastache rugosa Species 0.000 description 1
- 244000296912 Ageratum conyzoides Species 0.000 description 1
- 235000004405 Ageratum conyzoides Nutrition 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 206010007027 Calculus urinary Diseases 0.000 description 1
- 235000016535 Capraria biflora Nutrition 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 244000160089 Crataegus cuneata Species 0.000 description 1
- 235000008440 Crataegus cuneata Nutrition 0.000 description 1
- 235000017159 Crataegus pinnatifida Nutrition 0.000 description 1
- 235000014283 Crataegus pinnatifida var major Nutrition 0.000 description 1
- 229920002785 Croscarmellose sodium Polymers 0.000 description 1
- 101710112752 Cytotoxin Proteins 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 240000001811 Dioscorea oppositifolia Species 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010059186 Early satiety Diseases 0.000 description 1
- 208000008967 Enuresis Diseases 0.000 description 1
- 206010053155 Epigastric discomfort Diseases 0.000 description 1
- 208000015220 Febrile disease Diseases 0.000 description 1
- 102100021022 Gastrin Human genes 0.000 description 1
- 108010052343 Gastrins Proteins 0.000 description 1
- 208000005232 Glossitis Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 241000589989 Helicobacter Species 0.000 description 1
- 208000000616 Hemoptysis Diseases 0.000 description 1
- 206010049077 Hernia pain Diseases 0.000 description 1
- 235000017309 Hypericum perforatum Nutrition 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 208000015817 Infant Nutrition disease Diseases 0.000 description 1
- 244000118681 Iresine herbstii Species 0.000 description 1
- 240000006859 Jasminum officinale Species 0.000 description 1
- 235000010254 Jasminum officinale Nutrition 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 241000366676 Justicia pectoralis Species 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 241000234280 Liliaceae Species 0.000 description 1
- 241000218377 Magnoliaceae Species 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 201000005505 Measles Diseases 0.000 description 1
- 208000037093 Menstruation Disturbances Diseases 0.000 description 1
- 206010027339 Menstruation irregular Diseases 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 206010067994 Mucosal atrophy Diseases 0.000 description 1
- 206010061297 Mucosal erosion Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 1
- 244000236658 Paeonia lactiflora Species 0.000 description 1
- 240000004371 Panax ginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 241000286209 Phasianidae Species 0.000 description 1
- 208000005374 Poisoning Diseases 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 241001038562 Pseudostellaria heterophylla Species 0.000 description 1
- 241000218201 Ranunculaceae Species 0.000 description 1
- 206010067171 Regurgitation Diseases 0.000 description 1
- 240000001341 Reynoutria japonica Species 0.000 description 1
- 235000018167 Reynoutria japonica Nutrition 0.000 description 1
- 241000736078 Schisandra sphenanthera Species 0.000 description 1
- 241001121987 Scrophularia ningpoensis Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- 235000008326 Trichosanthes anguina Nutrition 0.000 description 1
- 241000975594 Trichosanthes rosthornii Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 206010000059 abdominal discomfort Diseases 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 229940039750 aconitine Drugs 0.000 description 1
- STDXGNLCJACLFY-UHFFFAOYSA-N aconitine Natural products CCN1CC2(COC)C(O)CC(O)C34C5CC6(O)C(OC)C(O)C(OC(=O)C)(C5C6OC(=O)c7ccccc7)C(C(OC)C23)C14 STDXGNLCJACLFY-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 208000038016 acute inflammation Diseases 0.000 description 1
- 230000006022 acute inflammation Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000005784 autoimmunity Effects 0.000 description 1
- 238000009412 basement excavation Methods 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 239000008116 calcium stearate Substances 0.000 description 1
- 235000013539 calcium stearate Nutrition 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 208000019902 chronic diarrheal disease Diseases 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 229960001681 croscarmellose sodium Drugs 0.000 description 1
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 1
- 231100000599 cytotoxic agent Toxicity 0.000 description 1
- 239000002619 cytotoxin Substances 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- GXGAKHNRMVGRPK-UHFFFAOYSA-N dimagnesium;dioxido-bis[[oxido(oxo)silyl]oxy]silane Chemical compound [Mg+2].[Mg+2].[O-][Si](=O)O[Si]([O-])([O-])O[Si]([O-])=O GXGAKHNRMVGRPK-UHFFFAOYSA-N 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 206010060865 duodenogastric reflux Diseases 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000008378 epithelial damage Effects 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 230000005713 exacerbation Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 206010016766 flatulence Diseases 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 230000027119 gastric acid secretion Effects 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- -1 glidant Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 208000006278 hypochromic anemia Diseases 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 201000007227 lymph node tuberculosis Diseases 0.000 description 1
- 239000000391 magnesium silicate Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 229940099273 magnesium trisilicate Drugs 0.000 description 1
- 229910000386 magnesium trisilicate Inorganic materials 0.000 description 1
- 235000019793 magnesium trisilicate Nutrition 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 210000001809 melena Anatomy 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920006316 polyvinylpyrrolidine Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000005070 ripening Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 208000008281 urolithiasis Diseases 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 230000009278 visceral effect Effects 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/808—Scrophularia (figwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of Chinese medicine compositions and preparation method thereof for treating gastritis, belong to the Chinese medicine therapy field of gastritis.The present invention discloses a kind of Chinese medicine composition for treating gastritis, including following each component first：Rhizoma Dioscoreae, raw pueraria lobata, rhizoma anemarrhenae, the raw the membrane of a chicken's gizzard, pueraria lobata, Schisandra chinensis and root of Chinese trichosanthes.Chinese medicine composition of the present invention has exact therapeutic effect to chronic gastritis, and the comparison result of clinical efficacy proves to have obvious synergistic function between Rhizoma Dioscoreae, raw pueraria lobata, rhizoma anemarrhenae, the raw the membrane of a chicken's gizzard, pueraria lobata, Schisandra chinensis and root of Chinese trichosanthes.The present invention further addition bulk pharmaceutical chemicals Radix Ophiopogonis, Radix Paeoniae Alba, raw hawthorn, radix pseudostellariae and radix scrophulariae on the basis of Rhizoma Dioscoreae, raw pueraria lobata, rhizoma anemarrhenae, the raw the membrane of a chicken's gizzard, pueraria lobata, Schisandra chinensis and root of Chinese trichosanthes, have effects that better tonifying Qi promote the production of body fluid, smooth liver and relieve pain, spleen benefiting and stimulating the appetite.The effect of compatibility of Chinese medicine composition of the present invention is reasonable, treatment gastritis is definite, and has no toxic side effect.
Description
Technical field
The present invention relates to the Chinese medicine compositions and preparation method thereof for the treatment of chronic gastritis, belong to the Chinese medicine treatment neck of gastritis
Domain.
Background technology
Gastritis is stomach lining acute and chronic inflammation caused by a variety of different pathogenies, is often accompanied by epithelial damage, mucosal inflammation
Reaction and epithelium regeneration.Gastritis is one of most common disease of digestive system, by the emergency and course of disease length of clinical onset, generally
Gastritis is divided into acute gastritis and chronic gastritis.Chronic gastritis is also referred to as chronic gastritis, with gastric epithelial and body of gland atrophy, number
It reduces, stomach lining is thinning, and mucous membrane base thickens, or with gland metaplasia and intestinal gland metaplasia, or has atypical hyperplasia to be characterized
Chronic digestive system disease often shows as upper abdomen secret anguish, turgor, belch, loss of appetite, or becomes thin, anaemia etc., is that one kind is more
Pathogenic factor disease and precancerous lesion.
Chronic gastritis shortage specific symptom, the weight of symptom and the lesion degree of stomach lining are simultaneously non-uniform.Most of diseases
People is often asymptomatic or the indigestion symptom such as upper abdomen secret anguish, anorexia, post-prandial fullness, sour regurgitation etc. that has degree different.It is chronic
Gastritis sufferer can have anaemia, become thin, glossitis, diarrhea etc., and individuals patients are more apparent with mucosal erosion person's epigastric pain, and can have
Blood, such as spitting blood, melena.Symptom usually recurrent exerbation, irregularities abdominal pain, pain often arise in it is in feeding process or postprandial,
Majority is not fixed positioned at upper abdomen, navel week, some patientss position, and less serious case's intermittence secret anguish or dull pain, severe patient are violent angina.
Chronic gastritis is gastric mucosa chronic inflammation or chronic disease caused by different pathogeny, is clinically broadly divided into non-slow
Property gastritis (superficial gastritis), chronic gastritis and specific type gastritis three categories, are common clinicals, frequently-occurring disease, incidence
It occupies first of each stomach trouble, accounts for about and receive 80%~90% or more of gastrocopy patient, and its incidence increases with the age and increased.
Chronic non-chronic gastritis can develop into chronic gastritis, until gastric cancer, seriously threatens the life of patient.
Doctor trained in Western medicine is generally acknowledged that chronic gastritis disease because physical, chemically and biological adverse factor is persistently iteratively operating on
Susceptible population causes gastric mucosa chronic inflammation, the wherein digested boundary scholar of state unanimously to think the pathogenic factors and pylorus of chronic gastritis
The factors such as pylori (Hp) infection, autoimmunity, Duodenal reflux, environmental factor, mental element, age are related.Wherein pylorus
Helicobacter (Hp) is the main pathogenic of chronic gastritis, and helicobacter pylori increases gastric acid secretion by increasing gastrin；It is long
After phase infection, Mucosal atrophy and intestines can occur for some patientss, research shows that 80%~95% chronic active gastritis is suffered from
There are Hp infection in person's gastric mucosa, for chronic gastritis degree of inflammation with whether there is or not Hp infection and the proportional relationship of Hp bacterium amounts, eradicating Hp can
Stomach lining inflammation is set to subside, chronic inflammation degree mitigates, and becomes one of the key link for the treatment of chronic gastritis.
No. 201210133609.7 patents of invention of Chinese patent disclose a kind of Chinese medicine composition for treating chronic gastritis,
In parts by weight, including following components：Radix Codonopsis 12-18, Rhizoma Atractylodis Macrocephalae 9-15, Poria cocos 9-15, dried orange peel 5-7, tuber of pinellia 7-11, root of Aucklandia lappa Decne 7-
11, fructus amomi 2-4, monkshood 5-7, rhizoma zingiberis 5-7, root of Chinese trichosanthes 5-7.No. 200810115341.8 applications for a patent for invention of Chinese patent disclose
A kind of pharmaceutical composition and preparation method thereof that treating chronic gastritis, active ingredient of the invention be by Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Poria cocos,
Radix Paeoniae Alba, raw hawthorn, dried orange peel, fructus amomi, monkshood, rhizoma zingiberis, root of Chinese trichosanthes, Cortex Magnoliae Officinalis, pueraria lobata, the membrane of a chicken's gizzard are extracted to be formed.Above-mentioned two patent
All contain raw medicinal material monkshood in formula, monkshood is more toxic in public's common sense, is caused by aconitine-type alkaloids, poisoning symptom
Mainly based on the performance of nervous system, the circulatory system and digestive system, aconitine is larger to cardiac toxic.Though the rhizome of Chinese monkshood after processing
Bases content reduces, but there are still certain toxic side effect, there are prodigious security risks after human body is taken.
Functional dyspepsia FD (FD) is one group with glutted, abdomen after duration or repeatability breaking-out upper abdomen pain, food
The epigastric discomforts such as flatulence, belch, early satiety, apocleisis, nausea are the clinical syndrome of cardinal symptom.Due to functional dyspepsia FD
(FD) and Patients with Chronic Gastritis all has indigestion clinical symptoms, and specificity is not strong, and according to being diagnosed under gastroscope, FD with it is chronic
Gastritis is difficult to distinguish, and differentiates more difficult.But the two clinically belongs to two kinds of diseases, research shows that the two is in the cause of disease, diagnosis
With it is different in treatment.(1) cause of disease is different.Chronic gastritis often has characterized by stomach lining organic disease and causes mucous membrane
The clear cause of disease of damage, the wherein overwhelming majority is helicobacter pylori infections.Helicobacter pylori by produce ammonia, secretion cavitating toxin,
The mechanism such as cytotoxin and attraction neutrophil infiltration cause mucosal inflammation to damage.FD refers to one group of Upper abdominal pain or discomfort
Clinical syndrome, often has no the specific cause of disease, pathogenesis often with hydrochloric acid in gastric juice, digestive tract power is abnormal, visceral hypersensitivity
And the factors such as nervous anxiety are related.In document report, although there may be helicobacter pylori infections and antibacterial therapies for some patientss
Effectively, but long-term efficacy is not obvious.Show that Hp can cause indigestion without abundant proof at present.Hp is in FD recall rates and unknown
It is aobvious to be higher than crowd's control group, there is quite a few FD patient clinical symptom it is obvious that and being infected without Hp；Even if the FD of Hp infection suffers from
Person, chronic active gastritis lesion take a favorable turn or subsides after effecting a radical cure Hp, but its symptom improve and it is unsatisfactory.(2) lesion is special
Point is different.Be not in apparent lesion though FD patient symptoms can repeated, long-term existence.Either shallow stomach
Inflammation or chronic gastritis have different degrees of galandular epithelium lesion, small part to have the risk of canceration.(3) diagnostic method is different.
FD is to be based on symptomatic diagnosis, on condition that must exclude whether stomach lining has organic disease；The diagnosis of FD is retouching based on symptom
It states, emphasizes dyspeptic symptom.Chronic gastritis pays close attention to stomach lining pathology damage, is spy with Active inflammation and galandular epithelium lesion
Sign, endoscopic manifestations, which are the erosion of stomach lining or pathological biopsy, apparent neutrophil infiltration body of gland destruction or atrophy venereal disease
Become etc..(4) treatment emphasis is different.The therapeutic purpose of chronic gastritis be chiefly to facilitate stomach lining reparation prevent malignant change or
The generation of other complication induces the destruction of mucous membrane neutrophil infiltration and body of gland because the disease is mostly by helicobacter pylori infections,
Therefore it emphasizes etiological treatment, that is, eradicates helicobacter pylori.Symptomatic treatment is emphasized in the treatment of FD, alleviates symptom, quality of making the life better,
It is unrelated with stomach lining disease damage and reparation state.
No. 201110259190.5 applications for a patent for invention of Chinese patent disclose a kind of medicine for treating functional dyspepsia FD
Compositions, which is characterized in that calculate by weight, the composition by Radix Codonopsis 15, rhizoma atractylodis macrocephalae 10, Poria cocos 10, toast root of Chinese trichosanthes 5,
Stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice 10, root of Aucklandia lappa Decne 10, fructus amomi 6, stir-baked RHIZOMA CORYDALIS with vinegar 15 and rhizoma pinellinae praeparata 10 form；By adjust liver and spleen can be obviously improved fullness in stomach,
The symptoms such as epigastric distending pain, deficiency of food be indigestion and loss of appetite, and WeiDongLi Capsule can be improved.
Though western medicine chronic gastritis is quick, drug resistance easily persistently occurs using Western medicine, treatment validity declines, and
Side effect is big.Therefore, a kind of Chinese medicine composition to chronic gastritis with definite curative effect is developed, there will be important value.
Invention content
Technical problem to be solved by the invention is to provide a kind of Chinese medicine composition for treating gastritis, which controls
The effect for the treatment of chronic gastritis is definite and without side-effects；
Another technical problem to be solved by this invention is to provide a kind of Chinese medicine composition and treats gastritis preparing
Drug in purposes.
In order to solve the above technical problems, the technical solution used in the present invention is：
The present invention discloses a kind of Chinese medicine composition for treating gastritis, including following each component first：Rhizoma Dioscoreae, raw Huang
Stilbene, rhizoma anemarrhenae, the raw the membrane of a chicken's gizzard, pueraria lobata, Schisandra chinensis and root of Chinese trichosanthes.
The parts by weight of each component are：20-50 parts of Rhizoma Dioscoreae, raw 5-20 parts of Radix Astragali, 5-20 parts of rhizoma anemarrhenae, raw the membrane of a chicken's gizzard 5-20
Part, 5-10 parts of pueraria lobata, 5-20 parts of Schisandra chinensis, 2-10 parts of root of Chinese trichosanthes.Preferably, the parts by weight of each component are：30 parts of Rhizoma Dioscoreae, life
15 parts of Radix Astragali, 18 parts of rhizoma anemarrhenae, raw 6 parts of the membrane of a chicken's gizzard, 5 parts of pueraria lobata, 10 parts of Schisandra chinensis, 10 parts of root of Chinese trichosanthes.
Rhizoma Dioscoreae is the dry rhizome of Dioscoreaceae plant Chinese yam Dioscorea opposita Thunb..Winter cauline leaf is withered
It is excavated after withering, cuts root head, cleaned, remove crust and fibrous root.It is mild-natured, it is sweet in flavor.
Tonifying spleen nourishing the stomach, engender liquid and benefic lung, the puckery essence of kidney tonifying.It breathes with cough not less than, the deficiency syndrome of the lung for spleen eating less, chronic diarrhea, emission due to the kidney deficiency, band
Under, frequent micturition, abnormal heat quench one's thirst.
Raw Radix Astragali is the dry root of legume Radix Astragali or Inner Mongolia Astragalis.Radix Astragali nature and flavor are sweet, tepor, and returns spleen, lung channel are
Qi-tonifying drug.
Rhizoma anemarrhenae, the dry rhizome of monocotyledon Liliaceae rhizoma anemarrhenae.It is bitter in taste, it trembles with fear.Return lung, stomach, kidney channel.Clearing heat-fire,
Nourishing Yin and moistening dryness.Pyreticosis polydipsia, lung-heat type cough, osteopyrexia and fever, Heat Diabetes, dry constipation of intestines.
The raw the membrane of a chicken's gizzard is the drying inner wall of sandbag of Phasianidae animal family chicken Gallusgallusdomesticus Brisson.
After killing chicken, chicken gizzard is taken out, peels inner wall, cleaning, drying immediately.Nature and flavor sweet and neutral.Returns spleen, stomach, small intestine, bladder warp.Stomach invigorating disappears
Food, arresting seminal emission, treating stranguria fossil.For dyspepsia, vomiting dysentery, infantile malnutrition, the enuresis, seminal emission, the puckery pain of urolithiasis, courage the is swollen side of body
Bitterly.
Pueraria lobata, the dry root of legume pueraria lobata are practised and claim elegant jessamine.Autumn, the excavation of two season of winter, take advantage of fresh-cut into sheet or fritter；
It is dry.It is sweet, pungent, it is cool.There is expelling pathogenic factors from muscles and skin to bring down a fever, promoting eruption promotes the production of body fluid to quench thirst, the work(of Shengyang Zhixie.It is usually used in exterior syndrome to generate heat, stiff nape and back,
Measles without adequate eruption, pyreticosis is thirsty, and the deficiency of Yin is quenched one's thirst, and heat is purged heat dysentery, splenasthenic diarrhea.
Schisandra chinensis is magnoliaceae schisandra Schisandra chinensis (Turcz.) Baill. or Central China five tastes
The dry mature fruit of sub- Schisandra sphenanthera Rehd.et Wils..It astringes the lung, nourshing kidney is promoted the production of body fluid, and sweat is received, puckery
Essence.It controls the deficiency syndrome of the lung to breath with cough, thirst, spontaneous perspiration, night sweat, internal lesion caused by overexertion is thin thin, emission, protracted dysentery and diarrhea.
The dry root of root of Chinese trichosanthes, cucurbitaceous plant snakegourd or trichosanthes rosthornii Harms.Clearing heat-fire promotes the production of body fluid to quench thirst, apocenosis detumescence.It is main
It controls：Control that pyreticosis is thirsty, quenches one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle swells, hemorrhoid impotence.For treating diabetes, commonly uses it and coordinate with drugs for nourishing yin
It uses, to have the function that treating both manifestation and root cause of disease.
The present invention adds bulk pharmaceutical chemicals pueraria lobata and five on the basis of Rhizoma Dioscoreae, raw Radix Astragali, rhizoma anemarrhenae, the raw the membrane of a chicken's gizzard and root of Chinese trichosanthes
Taste has the effect of better supplementing qi and nourishing yin.
The comparison result of clinical efficacy shows the present invention by Rhizoma Dioscoreae, raw Radix Astragali, rhizoma anemarrhenae, the raw the membrane of a chicken's gizzard, pueraria lobata, the five tastes
It is 94% that Chinese medicine composition prepared by son and root of Chinese trichosanthes has definite curative effect, treatment obvious effective rate to chronic gastritis, total effective rate
Up to 100%；Treatment obvious effective rate and total effective rate are apparently higher than on Rhizoma Dioscoreae, raw Radix Astragali, rhizoma anemarrhenae, the raw the membrane of a chicken's gizzard and root of Chinese trichosanthes basis
Upper addition Radix Angelicae Sinensis and radix paeoniae rubra or other bulk pharmaceutical chemicals such as the fleece-flower root and ginger, have been respectively increased 20 percentage points and 10 percentage points
More than, and it is without side-effects.Result above proves that Rhizoma Dioscoreae gives birth to Radix Astragali, rhizoma anemarrhenae, the raw the membrane of a chicken's gizzard, root of Chinese trichosanthes and pueraria lobata, the five tastes
It is had obvious synergistic function between son.
The present invention further discloses a kind of Chinese medicine compositions for treating gastritis, including following each component：Rhizoma Dioscoreae, raw Huang
Stilbene, rhizoma anemarrhenae, the raw the membrane of a chicken's gizzard, pueraria lobata, Schisandra chinensis, root of Chinese trichosanthes, Radix Ophiopogonis, piece Radix Paeoniae Alba, raw hawthorn, radix pseudostellariae and radix scrophulariae.
The parts by weight of each component are：20-50 parts of Rhizoma Dioscoreae, raw 5-20 parts of Radix Astragali, 5-20 parts of rhizoma anemarrhenae, raw the membrane of a chicken's gizzard 5-20
Part, 5-10 parts of pueraria lobata, 5-20 parts of Schisandra chinensis, 2-10 parts of root of Chinese trichosanthes, Radix Ophiopogonis 5-25 part, 20-50 parts of Radix Paeoniae Alba, 5-20 parts of raw hawthorn,
5-20 parts of radix pseudostellariae, 5-20 parts of radix scrophulariae.
Preferably, the parts by weight of each component are：20-50 parts of Rhizoma Dioscoreae, raw 5-20 parts of Radix Astragali, 5-20 parts of rhizoma anemarrhenae, in live chickens
5-20 parts golden, 5-10 parts of pueraria lobata, 5-20 parts of Schisandra chinensis, 2-10 parts of root of Chinese trichosanthes, Radix Ophiopogonis 5-25 part, 20-50 parts of Radix Paeoniae Alba, raw hawthorn 5-
20 parts, 5-20 parts of radix pseudostellariae, 5-20 parts of radix scrophulariae.
Radix Ophiopogonis is liliaceous plant Radix Ophiopogonis (dwarf lilyturf) Ophiopogon japonicus (Thunb.) Ker-Gawl.'s
Dried root.Nature and flavor are sweet, and slight bitter is slightly cold.The thoughts of returning home, lung, stomach.Nourishing Yin and promoting production of body fluid, moistening lung clears away heart-fire.For dryness of the lung dry cough.Consumptive disease cough
It coughs, injury thirst, vexed insomnia, Heat Diabetes, dry constipation of intestines；Pharyngeal diphtheria.
Radix Paeoniae Alba, the dry root of ranunculaceae plant Chinese herbaceous peony Paeonia lactiflora Pall..It is bitter in taste, sour, it is slightly cold.Return
Liver, the spleen channel.
Smooth liver and relieve pain, nourishing blood for regulating menstruation, astringing YIN to stop sweating.For dizziness of having a headache, hypochondriac pain, abdominal pain, four limbs contraction pain, blood deficiency chlorosis,
Irregular menstruation, spontaneous perspiration, night sweat.
Raw hawthorn is rosaceous plant large-fruited Chinese hawthorn Crataegus pinnatifida Bge.var.major N.E.Br.
Or the ripening fruits of hawthorn Crataegus pinnatifida Bge..Nature and flavor are sour, sweet, tepor.Returns spleen, stomach, Liver Channel.It helps digestion strong
Stomach, scattered stasis.For meat stagnation, gastral cavilty turgor, diarrhea dysentery abdominal pain, blood stasis closed, postpartum stasis, confidant sting, hernia pain
Bitterly；Hyperlipidemia.Charred FRUCTUS CRATAEGI promoting digestion effect enhancing.For meat stagnation, rush down dysentery is not well.
Radix pseudostellariae, pinkwort caryophyllaceous ginseng Pseudostellaria heterophylla (Miq.) Pax ex Pax
The dried root of et Hoffm..Nature and flavor are sweet, slight bitter, put down.Returns spleen, lung channel.It replenishes qi to invigorate the spleen, it is promoting production of body fluid and nourishing the lung.It is tired for spleen deficiency body,
Loss of appetite, eak after being ill, deficiency of both vital energy and Yin, spontaneous perspiration is thirsty, dryness of the lung dry cough.
Radix scrophulariae is the dry root of goatweed radix scrophulariae Scrophularia ningpoensis Hemsl..Nature and flavor are sweet,
It is bitter, salty, it is slightly cold.Return lung, stomach, kidney channel.Cool blood enriching yin, purging intense heat and detonicating.For consumption of YIN caused by febrile disease, the deep red polydipsia of tongue, febrile virulent maculae, Tianjin wound
Constipation, hectic fever due to yin labor is coughed, hot eyes, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus.
The present invention further adds on the basis of Rhizoma Dioscoreae, raw Radix Astragali, rhizoma anemarrhenae, the raw the membrane of a chicken's gizzard, pueraria lobata, Schisandra chinensis and root of Chinese trichosanthes
Add bulk pharmaceutical chemicals Radix Ophiopogonis, piece Radix Paeoniae Alba, raw hawthorn, radix pseudostellariae and radix scrophulariae, there is better tonifying Qi to promote the production of body fluid, smooth liver and relieve pain, spleen benefiting and stimulating the appetite
The effect of.
Clinical diagnosis be the patient of chronic gastritis take the present invention by Rhizoma Dioscoreae, raw Radix Astragali, rhizoma anemarrhenae, the raw the membrane of a chicken's gizzard, pueraria lobata,
Chinese medicine composition prepared by Schisandra chinensis, root of Chinese trichosanthes, Radix Ophiopogonis, piece Radix Paeoniae Alba, raw hawthorn, radix pseudostellariae and radix scrophulariae, treatment obvious effective rate reach
82%, total effective rate is curative for effect up to 98%.
The invention also discloses a kind of preparation methods of the Chinese medicine composition, include the following steps：According to the weight
Part weighs each component, is uniformly mixed, and adds 10 times of amount water to impregnate 0.5h, refluxing extraction 1.5h obtains filtrate, spare；Filter residue adds 8 times of amounts
Water, refluxing extraction 1.0h, obtains filtrate；Merging filtrate is concentrated under reduced pressure into density 1.15 (60 DEG C), and it is auxiliary to add pharmaceutically acceptable drug
Material, is made granule, tablet, hard capsule.
The invention also discloses purposes of the Chinese medicine composition in the drug for preparing treatment gastritis.
Gastritis of the present invention is chronic gastritis, also referred to as chronic gastritis, and with gastric epithelial and body of gland atrophy, number subtracts
Few, stomach lining is thinning, and mucous membrane base thickens, or with gland metaplasia and intestinal gland metaplasia, or has atypical hyperplasia to be characterized.Card is shown in
Gastral cavilty inflation is uncomfortable, and pain fixes, meets cold exacerbation, and arteries and veins is thin and delicate and puckery.
On the basis of Chinese medicine composition of the present invention, treatment gastritis can be prepared by adding suitable auxiliary material or carrier
Drug.Wherein, the dosage form of the drug includes but not limited to：Tablet, granule, capsule.
Carrier or auxiliary material of the present invention refer to the carrier or auxiliary material of pharmaceutical field routine, such as：Diluent bursts apart
Agent, lubricant, excipient, adhesive, glidant, filler, surfactant, flavouring agent, sweetener etc..The diluent packet
Include lactose, starch, pregelatinized starch, microcrystalline cellulose, sorbierite, mannitol and inorganic calcium salt etc..The disintegrant can be with
For one of crosslinked polyvinylpyrrolidone, croscarmellose sodium, alginic acid, microcrystalline cellulose kind or several mixing
Object.The lubricant include one of stearic acid, odium stearate, magnesium stearate, calcium stearate, polyethylene glycol, talcum powder kind or
Several mixtures.Described adhesive can be starch slurry, hydroxypropyl methyl cellulose, polyvinylpyrrolidine.The glidant can
Think one of superfine silica gel powder, talcum powder, magnesium trisilicate kind or several mixtures.The surfactant can be a kind of or several
Kind can improve wetability and increase the ingredient of drug-eluting, be commonly used for lauryl sodium sulfate.
Each taste bulk pharmaceutical chemicals used in the present invention can be commercially available in pharmacy.
The usage and dosage of Chinese medicine composition of the present invention：The present invention dosage depend on specific dosage form, patient age,
The factors such as health status.As guidance, usage and dosage：Electuary, 3 to 5 grams oral every time, 1-2 times on the one, 15 days are a treatment
Journey.
Technical solution of the present invention compared with prior art, has the advantages that：
The compatibility of Chinese medicine composition of the present invention is reasonable, bulk pharmaceutical chemicals Rhizoma Dioscoreae, raw Radix Astragali, rhizoma anemarrhenae, the raw the membrane of a chicken's gizzard, root of Chinese trichosanthes with
It has obvious synergistic function between pueraria lobata, Schisandra chinensis, the obvious effective rate for the treatment of chronic gastritis can be significantly improved and always has
Efficiency.The present invention further adds on the basis of Rhizoma Dioscoreae, raw Radix Astragali, rhizoma anemarrhenae, the raw the membrane of a chicken's gizzard, pueraria lobata, Schisandra chinensis and root of Chinese trichosanthes
Bulk pharmaceutical chemicals Radix Ophiopogonis, piece Radix Paeoniae Alba, raw hawthorn, radix pseudostellariae and radix scrophulariae promote the production of body fluid with better tonifying Qi, smooth liver and relieve pain, spleen benefiting and stimulating the appetite
Effect.The preparation process of Chinese medicine composition of the present invention is simple, and treatment gastritis is curative for effect, has no toxic side effect, application prospect is good.
Specific implementation mode
The invention will now be further described with reference to specific embodiments, the advantages and features of the present invention will be with description and
It is apparent.It should be understood that described, examples are merely exemplary, does not constitute any restrictions to the scope of the present invention.This field
Technical staff should be understood that without departing from the spirit and scope of the invention can to the details of technical solution of the present invention and
Form is modified or is replaced, but these modifications or substitutions each fall within protection scope of the present invention.
The preparation of 1 powder of embodiment
Each component (g) is weighed according to following ratio：Rhizoma Dioscoreae 20, raw Radix Astragali 5, rhizoma anemarrhenae 5, the raw the membrane of a chicken's gizzard 5, pueraria lobata 8, the five tastes
Son 5, root of Chinese trichosanthes 2；Be crushed to 100 mesh, be uniformly mixed to get.
The preparation of 2 powder of embodiment
Each component (g) is weighed according to following ratio：Rhizoma Dioscoreae 50, raw Radix Astragali 20, rhizoma anemarrhenae 20, the raw the membrane of a chicken's gizzard 20, pueraria lobata 10,
Schisandra chinensis 20, root of Chinese trichosanthes 10；Be crushed to 300 mesh, be uniformly mixed to get.
The preparation of 3 powder of embodiment
Each component (g) is weighed according to following ratio：Rhizoma Dioscoreae 30, raw Radix Astragali 10, rhizoma anemarrhenae 10, the raw the membrane of a chicken's gizzard 10, pueraria lobata 10,
Schisandra chinensis 10, root of Chinese trichosanthes 6；Be crushed to 200 mesh, be uniformly mixed to get.
The preparation of 4 powder of embodiment
Each component (g) is weighed according to following ratio：Rhizoma Dioscoreae 20, raw Radix Astragali 5, rhizoma anemarrhenae 5, the raw the membrane of a chicken's gizzard 5, pueraria lobata 5, the five tastes
Son 5, root of Chinese trichosanthes 2, Radix Ophiopogonis 5, Radix Paeoniae Alba 20, raw hawthorn 5, radix pseudostellariae 5, radix scrophulariae 5；Be crushed to 100 mesh, be uniformly mixed to get.
The preparation of 5 powder of embodiment
Each component (g) is weighed according to following ratio：Rhizoma Dioscoreae 50, raw Radix Astragali 20, rhizoma anemarrhenae 20, the raw the membrane of a chicken's gizzard 20, pueraria lobata 10,
Schisandra chinensis 20, root of Chinese trichosanthes 10, Radix Ophiopogonis 25, Radix Paeoniae Alba 50, raw hawthorn 20, radix pseudostellariae 20, radix scrophulariae 20；300 mesh are crushed to, mixing is equal
It is even to get.
The preparation of 6 powder of embodiment
Each component (g) is weighed according to following ratio：Rhizoma Dioscoreae 30, raw Radix Astragali 10, rhizoma anemarrhenae 10, the raw the membrane of a chicken's gizzard 10, pueraria lobata 30,
Schisandra chinensis 10, root of Chinese trichosanthes 6, Radix Ophiopogonis 10, Radix Paeoniae Alba 10, raw hawthorn 10, radix pseudostellariae 10, radix scrophulariae 10；200 mesh are crushed to, are uniformly mixed,
To obtain the final product.
The preparation of 7 granule of embodiment
Each component (g) is weighed according to following ratio：Rhizoma Dioscoreae 300, raw Radix Astragali 100, rhizoma anemarrhenae 100, the raw the membrane of a chicken's gizzard 100, Pueraria lobota
Root 100, Schisandra chinensis 100, root of Chinese trichosanthes 60；It is uniformly mixed, adds 10 times of amount water to impregnate 0.5h, refluxing extraction 1.5h obtains filtrate, standby
With；Filter residue adds 8 times of amount water, refluxing extraction 1.0h to obtain filtrate；Merging filtrate is concentrated under reduced pressure into density 1.20-1.25 (60 DEG C), then
It is uniformly mixed in right amount with dextrin, softwood processed；It is pelletized by 16 mesh nylon mesh, in 60 DEG C of dryings, dry granular is after 16 mesh sieves.
The preparation of 8 capsule of embodiment
Each component (g) is weighed according to following ratio：Rhizoma Dioscoreae 300, raw Radix Astragali 100, rhizoma anemarrhenae 100, the raw the membrane of a chicken's gizzard 100, Pueraria lobota
Root 100, Schisandra chinensis 100, root of Chinese trichosanthes 60；It is uniformly mixed, adds 10 times of amount water to impregnate 0.5h, refluxing extraction 1.5h obtains filtrate, standby
With；Filter residue adds 8 times of amount water, refluxing extraction 1.0h to obtain filtrate；Merging filtrate is concentrated under reduced pressure into density 1.25-1.28 (60 DEG C), then
It is uniformly mixed in right amount with dextrin, softwood processed；It is pelletized by 16 mesh nylon mesh, in 60 DEG C of dryings, dry granular is after 16 mesh sieves, dress
Enter capsule to obtain the final product.
The clinical observation on the therapeutic effect of 1 traditional Chinese medicine composition for treating chronic gastritis of test example is tested
By the patient 650 that clinical diagnosis is chronic gastritis, cardinal symptom is that gastral cavilty inflation is uncomfortable, pain fixes, belch,
Loss of appetite etc., is randomly divided into 13 groups of (each group patient no significant difference (P in terms of gender, age and the state of an illness>
0.05), it is comparable), wherein 1 group is control group, any drug therapy is not used, another 12 groups use following Chinese medicine group respectively
Close object 1-12 (units：g)：
Chinese medicine composition 1：Rhizoma Dioscoreae 30, raw Radix Astragali 10, rhizoma anemarrhenae 10, the raw the membrane of a chicken's gizzard 10, root of Chinese trichosanthes 6；
Chinese medicine composition 2-8 adds following bulk pharmaceutical chemicals on the basis of Chinese medicine composition 1 respectively：
Chinese medicine composition 2：Pueraria lobata 30, Schisandra chinensis 10；
Chinese medicine composition 3：Hawthorn 30, Radix Paeoniae Alba 10；
Chinese medicine composition 4：Wrinkled giant hyssop 35, Cortex Magnoliae Officinalis 10；
Chinese medicine composition 5：Radix Angelicae Sinensis 20, radix paeoniae rubra 10；
Chinese medicine composition 6：Fructus amomi 30, ginger 10；
Chinese medicine composition 7：Radix Glycyrrhizae 10, corydalis tuber 10；
Chinese medicine composition 8：Poria cocos 30, rhizoma cyperi 10；
Chinese medicine composition 9：Galingal 20, the membrane of a chicken's gizzard 10；
Chinese medicine composition 10：Root of Aucklandia lappa Decne 10, the tuber of pinellia 10；
Chinese medicine composition 11：Rhizoma cyperi 15, fructus amomi 10；
Chinese medicine composition 12：Radix Codonopsis 20, snakegourd 10；
The preparation method of each Chinese medicine composition is with embodiment 3, application method：Boiling water is taken after mixing it with water, and is taken daily twice, every time
5g counts curative effect to treat 15d as 1 course for the treatment of after 3 courses for the treatment of.
Efficacy assessment standard：
It is effective：Clinical malaise symptoms disappear or mostly disappear, gastroscope check inflammation fully recover or are clearly better；
Effectively：Clinical malaise symptoms mitigate or part mitigates, and gastroscope check inflammation is improved；
In vain：Clinical malaise symptoms are unchanged, or even aggravate, and gastroscope check nothing is clearly better.
The comparison result of clinical efficacy is shown in Table 1.Total effective rate/%=obvious effective rates+effective percentage.
The effect of the different traditional Chinese medicine composition for treating chronic gastritis of table 1
The result shows that the present invention adds pueraria lobata and five on the basis of Rhizoma Dioscoreae, raw Radix Astragali, rhizoma anemarrhenae, the raw the membrane of a chicken's gizzard, root of Chinese trichosanthes
Chinese medicine composition 2 prepared by taste has significant therapeutic effect, effective 41 people, obvious effective rate 82% to chronic gastritis；Effective 8
People, effective percentage are 16%, and total effective rate is up to 98%；Its obvious effective rate and total effective rate are apparently higher than other Chinese medicine compositions, respectively
Improve 20 percentage points and nearly 10 percentage point or more.And observe in the treatment, the patient for taking Chinese medicine composition 2 is not
There is obvious adverse reaction, the blood of patient, urine, stool routine and Liver and kidney function are checked, exception is showed no.
Result above proves, pueraria lobata, five are added on the basis of Rhizoma Dioscoreae, raw Radix Astragali, rhizoma anemarrhenae, the raw the membrane of a chicken's gizzard, root of Chinese trichosanthes
Taste can significantly improve the obvious effective rate and total effective rate for the treatment of chronic gastritis.Illustrate, Rhizoma Dioscoreae, raw Radix Astragali, rhizoma anemarrhenae, live chickens
It is had obvious synergistic function between interior gold, root of Chinese trichosanthes and pueraria lobata, Schisandra chinensis.
2 traditional Chinese medicine composition for treating chronic gastritis of test example
By 112 people of patient that clinical diagnosis is chronic gastritis, the Chinese medicine composition of the embodiment of the present invention 6, boiling water punching are taken
Clothes, twice daily, each 3-5g, (clinical malaise symptoms disappear or mostly disappear, gastroscope check inflammation to the obvious effective rate for the treatment of 30 days
Fully recover or be clearly better) it is 97.8%, total effective rate 100%.
Claims (9)
1. a kind of Chinese medicine composition for treating gastritis, which is characterized in that be made of following each component：Rhizoma Dioscoreae, is known raw Radix Astragali
Female, the raw the membrane of a chicken's gizzard, pueraria lobata, Schisandra chinensis and root of Chinese trichosanthes.
2. Chinese medicine composition described in accordance with the claim 1, which is characterized in that the parts by weight of each component are：Rhizoma Dioscoreae 20-50
Part, raw 5-20 parts of pueraria lobata, 5-20 parts of rhizoma anemarrhenae, raw 5-20 parts of the membrane of a chicken's gizzard, 5-10 parts of pueraria lobata, 5-20 parts of Schisandra chinensis, root of Chinese trichosanthes 5-20
Part.
3. Chinese medicine composition described in accordance with the claim 1, which is characterized in that the parts by weight of each component are：30 parts of Rhizoma Dioscoreae, life
15 parts of Radix Astragali, 18 parts of rhizoma anemarrhenae, raw 6 parts of the membrane of a chicken's gizzard, 5 parts of pueraria lobata, 10 parts of Schisandra chinensis, 10 parts of root of Chinese trichosanthes.
4. a kind of Chinese medicine composition for treating gastritis, which is characterized in that be made of following each component：Rhizoma Dioscoreae, is known raw Radix Astragali
Female, the raw the membrane of a chicken's gizzard, pueraria lobata, Schisandra chinensis, root of Chinese trichosanthes, Radix Ophiopogonis, Radix Paeoniae Alba, raw hawthorn, radix pseudostellariae and radix scrophulariae.
5. Chinese medicine composition according to claim 4, which is characterized in that the parts by weight of each component are：Rhizoma Dioscoreae 20-50
Part, raw 5-20 parts of Radix Astragali, 5-20 parts of rhizoma anemarrhenae, raw 5-20 parts of the membrane of a chicken's gizzard, 5-10 parts of pueraria lobata, 5-20 parts of Schisandra chinensis, root of Chinese trichosanthes 2-10
Part, Radix Ophiopogonis 5-25 part, 20-50 parts of Radix Paeoniae Alba, 5-20 parts of raw hawthorn, 5-20 parts of radix pseudostellariae, 5-20 parts of radix scrophulariae.
6. Chinese medicine composition according to claim 4, which is characterized in that the parts by weight of each component are：30 parts of Rhizoma Dioscoreae, life
15 parts of Radix Astragali, 18 parts of rhizoma anemarrhenae, raw 6 parts of the membrane of a chicken's gizzard, 5 parts of pueraria lobata, 10 parts of Schisandra chinensis, 10 parts of root of Chinese trichosanthes, 10 parts of Radix Ophiopogonis, Radix Paeoniae Alba 30
Part, 20 parts of raw hawthorn, 10 parts of radix pseudostellariae, 20 parts of radix scrophulariae.
7. the preparation method of Chinese medicine composition described in a kind of claim 1 to 6 any one, which is characterized in that including following step
Suddenly：Weigh each component according to the parts by weight, be uniformly mixed, be crushed to 100-1200 mesh to get.
8. the preparation method of Chinese medicine composition described in a kind of claim 1 to 6 any one, which is characterized in that including following step
Suddenly：Each component is weighed according to the parts by weight, is uniformly mixed, 10 times of amount water is added to impregnate 0.5h, refluxing extraction 1.5h obtains filtrate,
It is spare；Filter residue adds 8 times of amount water, refluxing extraction 1.0h to obtain filtrate；Merging filtrate is concentrated under reduced pressure into density 1.20-130 (60 DEG C),
Pharmaceutically acceptable excipient substance is added, granule, tablet, hard capsule is made.
9. purposes of the Chinese medicine composition in the drug for preparing treatment chronic gastritis described in claim 1 to 6 any one.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810328491.0A CN108283685A (en) | 2018-04-12 | 2018-04-12 | Treat the Chinese medicine composition and preparation method thereof of chronic gastritis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810328491.0A CN108283685A (en) | 2018-04-12 | 2018-04-12 | Treat the Chinese medicine composition and preparation method thereof of chronic gastritis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108283685A true CN108283685A (en) | 2018-07-17 |
Family
ID=62834484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810328491.0A Pending CN108283685A (en) | 2018-04-12 | 2018-04-12 | Treat the Chinese medicine composition and preparation method thereof of chronic gastritis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108283685A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1864727A (en) * | 2006-02-07 | 2006-11-22 | 彭安泽 | A medicine for treating chronic gastritis |
| CN101062265A (en) * | 2007-05-23 | 2007-10-31 | 陈江 | Powder of smallpox and rehmannia |
-
2018
- 2018-04-12 CN CN201810328491.0A patent/CN108283685A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1864727A (en) * | 2006-02-07 | 2006-11-22 | 彭安泽 | A medicine for treating chronic gastritis |
| CN101062265A (en) * | 2007-05-23 | 2007-10-31 | 陈江 | Powder of smallpox and rehmannia |
Non-Patent Citations (3)
| Title |
|---|
| 张玉芳，张国泰: "张海岑研究员谈慢性胃炎的辨治", 《吉林中医药》 * |
| 李汉义: "《华佗神方》", 30 June 2013, 郑州中原农民出版社 * |
| 沙帮武等: "中西医结合治疗儿童慢性胃炎临床疗效观察", 《亚太传统医药》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104225441A (en) | Traditional Chinese medicine composition for treating stomach trouble and preparation method of granules and capsules of traditional Chinese medicine composition | |
| CN103393989B (en) | Traditional Chinese medicine composition for treating gynecologic inflammation | |
| CN104984267A (en) | Traditional Chinese medicine composition for treating lung cancer | |
| CN104606580A (en) | Traditional Chinese medicine preparation with synergistic effect on chemotherapy and preparation method of traditional Chinese medicine preparation traditional Chinese medicine preparation | |
| CN103055257B (en) | Traditional Chinese medicine for treating chronic gastritis and preparation method thereof | |
| CN104189784A (en) | Traditional Chinese medicine preparation for aphtha and preparation method of traditional Chinese medicine preparation | |
| CN103463449A (en) | Traditional Chinese medicine composite used for treating haemorrhoids and preparation method and application thereof | |
| CN103690869B (en) | Chinese medicine for the treatment of irritable bowel syndrome and preparation method thereof | |
| CN103520652B (en) | Traditional Chinese medicine composition for treating liver cancer | |
| CN108283685A (en) | Treat the Chinese medicine composition and preparation method thereof of chronic gastritis | |
| CN103127411B (en) | Traditional Chinese medicine used for treating urinary tract infection disease | |
| CN103041233A (en) | Pharmaceutical composition for treating infantile diarrhea and preparation method thereof | |
| CN105999092A (en) | Traditional Chinese medicine pill for treating melanosis coli | |
| CN104998074A (en) | Traditional Chinese medicine for treating gastropathy and preparation method thereof | |
| CN104436098A (en) | Traditional Chinese medicine preparation for treating multiple intestinal polyps | |
| CN104257871B (en) | Scorching pharmaceutical composition of the acute lymphatic meshwork of type and preparation method thereof is accumulate for treating damp and hot poison | |
| CN108653685A (en) | A kind of Chinese medicine composition and preparation method thereof for treating hepatic sclerosis | |
| CN103656199B (en) | A kind of Chinese medicine for the treatment of deficiency of kidney yin syndrome cough | |
| CN106668299A (en) | Pill medicine for treating constipation, and preparation method of pill medicine | |
| CN106620506A (en) | Pill medicine for treating spleen dampness transporting dysfunction type mouth tinea and preparation method | |
| CN105709005A (en) | Breast rehabilitation promoting pill | |
| CN106309991A (en) | Traditional Chinese medicine compound for treating deficiency of kidney yin and preparation method thereof | |
| CN104667129A (en) | Medicine for treating rheumatic heart disease | |
| CN105106879A (en) | Traditional Chinese medicine preparation for treating gastric ulcer | |
| CN105031516A (en) | Chinese herbal unguent for curing erysipelas |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180717 |