CN108125991A - A kind of worker bee processing procedure of Chinese herbal medicine and its application - Google Patents
A kind of worker bee processing procedure of Chinese herbal medicine and its application Download PDFInfo
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- CN108125991A CN108125991A CN201810139936.0A CN201810139936A CN108125991A CN 108125991 A CN108125991 A CN 108125991A CN 201810139936 A CN201810139936 A CN 201810139936A CN 108125991 A CN108125991 A CN 108125991A
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- 238000012545 processing Methods 0.000 title claims abstract description 41
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- 235000012907 honey Nutrition 0.000 claims abstract description 49
- 239000007788 liquid Substances 0.000 claims abstract description 30
- 238000002360 preparation method Methods 0.000 claims abstract description 13
- 239000004615 ingredient Substances 0.000 claims abstract description 11
- 239000002674 ointment Substances 0.000 claims abstract description 4
- 239000006187 pill Substances 0.000 claims abstract description 3
- 239000003826 tablet Substances 0.000 claims abstract description 3
- 239000000203 mixture Substances 0.000 claims description 35
- 239000003814 drug Substances 0.000 claims description 19
- 238000002156 mixing Methods 0.000 claims description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
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- 235000006536 Dioscorea esculenta Nutrition 0.000 claims description 15
- 240000001811 Dioscorea oppositifolia Species 0.000 claims description 15
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 claims description 15
- 238000010438 heat treatment Methods 0.000 claims description 15
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- 244000025254 Cannabis sativa Species 0.000 claims description 2
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- 235000002991 Coptis groenlandica Nutrition 0.000 claims description 2
- 244000131316 Panax pseudoginseng Species 0.000 claims description 2
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 2
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- 238000007654 immersion Methods 0.000 claims description 2
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- 235000013976 turmeric Nutrition 0.000 claims 1
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Classifications
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
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- A61K35/56—Materials from animals other than mammals
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/287—Chrysanthemum, e.g. daisy
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- A61K36/40—Cornaceae (Dogwood family)
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Abstract
The present invention relates to Chinese herbal medicine processing technique fields, specifically disclose worker bee processing procedure and its application of a kind of Chinese herbal medicine, in honey of the present invention in the processing procedure of medicinal herbs, Chinese herbal medicine is made by worker bee, it to achieve the purpose that process it, is handled by worker bee brewing, can not only improve the dissolution rate of the effect of Chinese herbal medicine contains ingredient, also can macromolecular compound therein be converted into human body easily absorption or the small-molecule substance that can directly absorb simultaneously, enhances the pharmacodynamic feature of Chinese herbal medicine;In addition, being made by worker bee to Chinese herbal medicine, original bad smell is can obviously improve, while does not need to introduce any chemical substance, can avoid causing human body potentially hazardous;The worker bee processing procedure of Chinese herbal medicine of the present invention can be applied to Chinese herbal medicine field of deep, to obtain the deep processed products such as liquid preparation, ointment, pill or tablet.
Description
Technical field
The present invention relates to Chinese herbal medicine processing technique fields, and in particular to a kind of worker bee processing procedure of Chinese herbal medicine and its should
With.
Background technology
Chinese medicine preparation is according to theory of traditional Chinese medical science basis, according to a pharmacy of clinical demand use different from Chinese medicine property
Technology.Chinese medicine is unable to direct drug injection due to special smell or different pharmacology activities, resulting in it, and needs after processing
Can just it be used as medicine, this is a distinct characteristic of traditional Chinese medicine and pharmacy.By in the changeable Chinese medicine of processing chemical composition, enhance or subtract
Certain drug effect of weak drug such as in clinical practice, is more favorable for it frequently by the next smell for thoroughly changing drug is processed
People takes, and reduces or thoroughly eliminate the toxic side effect of drug.
At present, in the prior art, the concocting method of Chinese medicine is using water, vinegar or wine as solvent, and Chinese medicine is impregnated
Be the shortcomings that processing, reaches processing purpose, this technique the Chinese herbal medicine effective ingredients after processing still cannot by high-efficiency dissolution,
And the original disagreeable taste of Chinese herbal medicine does not significantly improve while has remained the ingredient of vinegar or wine again, influences Chinese medicine product
Quality.
Invention content
The invention is intended to provide one kind to be added with honey raw material, Chinese herbal medicine effective ingredients dissolution rate can obtain after treatment
Significantly improve, bad smell be improved significantly and do not remain Chinese herbal medicine processing procedure and its application of other smells.
In order to achieve the above objectives, technical solution of the present invention is as follows:
A kind of worker bee processing procedure of Chinese herbal medicine, it is characterised in that:It comprises the steps of:
(1)Cleaning with Chinese herbal is shredded, and 1g is pressed with water:The ratio mixing of 15mL, immersion 18 ~ for 24 hours, water is filtered off, is dried;
(2)Honey is diluted with water, and control moisture content is between 25 ~ 30%, agitating and heating, 65 ~ 70 DEG C of heating temperature, heating time
0.5 ~ 1h crosses 120 mesh sieve, obtains honey liquid;
(3)It weighs respectively by weight:Daisy_petal part, jasmine petal, sweet osmanthus valve, cuckoo petal and cape jasmine petal, after cleaning, with fruit
Wine presses 1g:The ratio mixing of 3mL is mixed thoroughly, after sealing 3 ~ 5 days, is taken out, dries, is milled, and is crossed 80 mesh sieve, is obtained pollen mixture;
(4)By step(1)Gained Chinese herbal medicine:Step(2)Gained honey liquid:Step(3)Gained pollen mixture presses 1g:
10mL :The ratio mixing of 2g, stirs evenly, pours into the artificial honeycomb by sterilization treatment, by worker bee to the medium-height grass that contains
Medicine ingredient carries out brewing processing, and pollen mixture is made, and honey liquid is made again, and brewing temperature is 20 ± 2 DEG C,
Brewing time is 7 ~ 10 days, obtains brewing mixture;
(5)By step(4)Gained brewing mixture is placed in open-top receptacle, is dried, is obtained containing honey component under natural conditions
Process Chinese herbal medicine.
Preferably, the step(1)Chinese herbal medicine be Chinese yam, ginseng, lilac daphne, glutinous rehmannia, radix scutellariae, Fructus Corni, the coptis or ginger
It is yellow.
Preferably, the step(3)In, it weighs respectively by weight:10 ~ 15 parts of daisy_petal part, 3 ~ 8 parts of jasmine petal, osmanthus
3 ~ 10 parts of 2 ~ 7 parts of petal, 13 ~ 21 parts of cuckoo petal and cape jasmine petal.
Preferably, the step(3)In, it weighs respectively by weight:13 parts of daisy_petal part, 6 parts of jasmine petal, sweet osmanthus valve 4
7 parts of part, 17 parts of cuckoo petal and cape jasmine petal.
The application of the worker bee processing procedure of the Chinese herbal medicine is the deep processed product field of Chinese herbal medicine.
Preferably, the deep processed product is liquid preparation, ointment, pill, tablet or pulvis.
The present invention has the following advantages:
(1)In honey of the present invention in the processing procedure of medicinal herbs, Chinese herbal medicine is made by worker bee, to reach what it was processed
Purpose is handled by worker bee brewing, can not only improve the dissolution rate of the effect of Chinese herbal medicine contains ingredient, also can while will be therein
Macromolecular compound is converted into the small-molecule substance that human body is easily absorbed or can directly be absorbed, and enhances the pharmacodynamic feature of Chinese herbal medicine;This
Outside, Chinese herbal medicine is made by worker bee, can obviously improve original bad smell, while do not need to introduce any chemicals
Matter can avoid causing human body potentially hazardous;
(2)In the worker bee processing procedure of Chinese herbal medicine of the present invention, added with the various petals such as Jasmine, sweet osmanthus, made by worker bee,
By containing the substance decompositions such as protein, polysaccharide, vitamin and acids be small-molecule substance, dissolving is in a liquid;Honey liquor
Body is made again by worker bee, by containing the substances such as amino acid, vitamin and carbohydrate contain in working process, with body fluid again
Medicinal herb components, the dissolving of petal ingredient together, synergy can be played, can not only further enhance drug action, and is same
When have the fragrance of pollen and honey;In formula, the natural anti-oxidation ingredient contained using honey petal protects product
Shield, can not only prevent active ingredient by oxidation and drug action weakens, and can also extend product storage period.
Specific embodiment
It elaborates in conjunction with specific embodiments to technical solution of the present invention.
Embodiment 1
A kind of worker bee processing procedure of Chinese herbal medicine, comprises the steps of:
(1)Chinese yam cleaning chopping, 1g is pressed with water:The ratio mixing of 15mL, impregnates 18h, filters off water, dry;
(2)Honey is diluted with water, and control moisture content is between 25 ~ 30%, agitating and heating, 65 DEG C of heating temperature, heating time
0.5h crosses 120 mesh sieve, obtains honey liquid;
(3)It weighs respectively by weight:10 parts of daisy_petal part, 3 parts of jasmine petal, 2 parts of sweet osmanthus valve, 13 parts of cuckoo petal and gardenia
After cleaning, 1g is pressed with fruit wine for 3 parts of valve:The ratio mixing of 3mL is mixed thoroughly, after sealing 3 days, is taken out, dries, is milled, and crosses 80 mesh sieve,
Obtain pollen mixture;
(4)By step(1)Gained Chinese yam:Step(2)Gained honey liquid:Step(3)Gained pollen mixture presses 1g:
10mL :The ratio mixing of 2g, stirs evenly, pours into the artificial honeycomb by sterilization treatment, by worker bee to the Chinese yam that contains
Ingredient carries out brewing processing, and pollen mixture is made, and honey liquid is made again, and brewing temperature is 20 ± 2 DEG C, is made
It is 7 days to make the time, obtains brewing mixture;
(5)By step(4)Gained brewing mixture is placed in open-top receptacle, is dried, is obtained containing honey component under natural conditions
Process Chinese yam;
The processing Chinese yam containing honey component of acquisition is subjected to deep processing by the prior art, is processed as honey mountain liquid formulations
Agent.
Embodiment 2
A kind of worker bee processing procedure of Chinese herbal medicine, comprises the steps of:
(1)The bud of lilac daphne is taken to clean chopping, 1g is pressed with water:The ratio mixing of 15mL, impregnates for 24 hours, filters off water, dry;
(2)Honey is diluted with water, and control moisture content is between 25 ~ 30%, agitating and heating, 70 DEG C, heating time 1h of heating temperature,
120 mesh sieve is crossed, obtains honey liquid;
(3)It weighs respectively by weight:15 parts of daisy_petal part, 8 parts of jasmine petal, 7 parts of sweet osmanthus valve, 21 parts of cuckoo petal and gardenia
After cleaning, 1g is pressed with fruit wine for 10 parts of valve:The ratio mixing of 3mL is mixed thoroughly, after sealing 3 ~ 5 days, is taken out, dries, is milled, crosses 80 mesh
Sieve, obtains pollen mixture;
(4)By step(1)The bud of gained lilac daphne:Step(2)Gained honey liquid:Step(3)Gained pollen mixture is pressed
1g : 10mL :The ratio mixing of 2g, stirs evenly, pours into the artificial honeycomb by sterilization treatment, by worker bee to containing
The bud ingredient of lilac daphne carries out brewing processing, and pollen mixture is made, and honey liquid is made again, and brewing temperature is
20 ± 2 DEG C, brewing time is 10 days, obtains brewing mixture;
(5)By step(4)Gained brewing mixture is placed in open-top receptacle, is dried, is obtained containing honey component under natural conditions
Process lilac daphne bud;
The bud of lilac daphne containing honey component is carried out by deep processing using the prior art, is processed as honey lilac daphne ointment.
Embodiment 3
A kind of worker bee processing procedure of Chinese herbal medicine, comprises the steps of:
(1)The fruit of Fructus Corni is taken to clean chopping, 1g is pressed with water:The ratio mixing of 15mL, impregnates 20h, filters off water, dry;
(2)Honey is diluted with water, and control moisture content is between 25 ~ 30%, agitating and heating, 65 DEG C, heating time 1h of heating temperature,
120 mesh sieve is crossed, obtains honey liquid;
(3)It weighs respectively by weight:13 parts of daisy_petal part, 6 parts of jasmine petal, 4 parts of sweet osmanthus valve, 17 parts of cuckoo petal and gardenia
After cleaning, 1g is pressed with fruit wine for 7 parts of valve:The ratio mixing of 3mL is mixed thoroughly, after sealing 4 days, is taken out, dries, is milled, and crosses 80 mesh sieve,
Obtain pollen mixture;
(4)By step(1)The fruit of gained Fructus Corni:Step(2)Gained honey liquid:Step(3)Gained pollen mixture
By 1g: 10mL :The ratio mixing of 2g, stirs evenly, the artificial honeycomb by sterilization treatment is poured into, by worker bee to containing
The fruit component of Fructus Corni carry out brewing processing, pollen mixture is made, honey liquid is made again, brewing temperature
It is 20 ± 2 DEG C to spend, and brewing time is 8 days, obtains brewing mixture;
(5)By step(4)Gained brewing mixture is placed in open-top receptacle, is dried, is obtained containing honey component under natural conditions
Process the fruit of Fructus Corni;
Deep processing is carried out to the fruit of Fructus Corni of the gained containing honey component using the prior art, is prepared as honey Fructus Corni ball
Agent.
The worker bee processing procedure effect experiment of Chinese herbal medicine
It is tested for selection Chinese yam;
Sample 1:Honey Chinese yam liquid preparation, preparation method are:Preceding 3 step is the same as embodiment 1, step(4)For:Step(1)Gained mountain
Medicine:Step(2)Gained honey liquid:Step(3)Gained pollen mixture
Mixed proportion be 1g: 10mL :2g, wherein, it is poured into after the mixing of honey liquid pollen mixture by sterilization treatment
Artificial honeycomb makes pollen mixture by worker bee, honey liquid is made again, and brewing temperature is 20 ± 2 DEG C, is made
It is after 7 ~ 10 days to make the time;Chinese yam uses the prior art, is processed with light-coloured vinegar;
(5)By step(4)Gained brewing mixture is placed in open-top receptacle, is dried under natural conditions, is by prior art preparation
Honey Chinese yam liquid preparation;
Sample 2:Embodiment 1 prepares medicinal herbs liquid preparation in gained honey, and wherein Chinese herbal medicine is Chinese yam;
Sample 3:Honey Chinese yam liquid preparation, preparation method are:Preceding 3 step is the same as embodiment 1, step(4)For:Step(1)Gained mountain
Medicine:Step(2)Gained honey liquid:Step(3)Gained pollen mixture
Mixed proportion be 1g: 10mL :2g, wherein, it is poured into after the mixing of honey liquid pollen mixture by sterilization treatment
Artificial honeycomb makes pollen mixture by worker bee, honey liquid is made again, and brewing temperature is 20 ± 2 DEG C, is made
It is after 7 ~ 10 days to make the time;Chinese yam is without processing;
(5)By step(4)Gained brewing mixture is placed in open-top receptacle, is dried under natural conditions, is by prior art preparation
Honey Chinese yam liquid preparation.
1. sensory evaluation
Assessment item and it the results are shown in Table 1;
It is 2 table of sample because the macromolecular substances contained are caused by oxidation by result in table 1 it is found that 1 and 3 surface layer table of sample is black
Layer is faint yellow, is the protective layer that surface layer has honey to be formed, this can not only keep medicinal herb components not oxidized, and can effectively reduce
Its bad smell.
2. composition detection
Detection method and project:Gross protein value measures, and assay method is micro-Kjeldahl, multiplied by with 6.25, measures
It the results are shown in Table shown in 2;Amino acid classes and assay, wherein free amino acid are measured using AA analyses are logical, hydrolyze ammonia
Base acid is measured using automatic amino acid analyzer external application mark method, and free amino acid measurement result is shown in Table 3, free amino acid with
Hydrolysis amino acid measures total amount and the results are shown in Table 4;
By data in table 2 it is found that the content of crude protein is apparently higher than other two sample in sample 2, so, the present invention uses work
Bee carries out processing processing to Chinese herbal medicine, can effectively dissolve the macromolecular substances wherein contained;By data in table 3 and table 4 it is found that sample
The content of free amino acid and hydrolysis amino acid is above remaining two groups in product 2, and therefore, Chinese herbal medicine is made by worker bee
It makes, can not only achieve the purpose that processing, and the dissolution rate of the active ingredient wherein contained can be improved.
Claims (6)
1. a kind of worker bee processing procedure of Chinese herbal medicine, it is characterised in that:It comprises the steps of:
(1)Cleaning with Chinese herbal is shredded, and 1g is pressed with water:The ratio mixing of 15mL, immersion 18 ~ for 24 hours, water is filtered off, is dried;
(2)Honey is diluted with water, and control moisture content is between 25 ~ 30%, agitating and heating, 65 ~ 70 DEG C of heating temperature, heating time
0.5 ~ 1h crosses 120 mesh sieve, obtains honey liquid;
(3)It weighs respectively by weight:Daisy_petal part, jasmine petal, sweet osmanthus valve, cuckoo petal and cape jasmine petal, after cleaning, with fruit
Wine presses 1g:The ratio mixing of 3mL is mixed thoroughly, after sealing 3 ~ 5 days, is taken out, dries, is milled, and is crossed 80 mesh sieve, is obtained pollen mixture;
(4)By step(1)Gained Chinese herbal medicine:Step(2)Gained honey liquid:Step(3)Gained pollen mixture presses 1g:
10mL :The ratio mixing of 2g, stirs evenly, pours into the artificial honeycomb by sterilization treatment, by worker bee to the medium-height grass that contains
Medicine ingredient carries out brewing processing, and pollen mixture is made, and honey liquid is made again, and brewing temperature is 20 ± 2 DEG C,
Brewing time is 7 ~ 10 days, obtains brewing mixture;
(5)By step(4)Gained brewing mixture is placed in open-top receptacle, is dried, is obtained containing honey component under natural conditions
Process Chinese herbal medicine.
2. the worker bee processing procedure of Chinese herbal medicine according to claim 1, it is characterised in that:The step(1)Chinese herbal medicine
It is Chinese yam, ginseng, lilac daphne, glutinous rehmannia, radix scutellariae, Fructus Corni, the coptis or turmeric.
3. the worker bee processing procedure of Chinese herbal medicine according to claim 2, it is characterised in that:The step(3)In, by weight
Part weighs respectively:10 ~ 15 parts of daisy_petal part, 3 ~ 8 parts of jasmine petal, 2 ~ 7 parts of sweet osmanthus valve, 13 ~ 21 parts of cuckoo petal and cape jasmine petal 3
~ 10 parts.
4. the worker bee processing procedure of Chinese herbal medicine according to claim 3, it is characterised in that:The step(3)In, by weight
Part weighs respectively:7 parts of 13 parts of daisy_petal part, 6 parts of jasmine petal, 4 parts of sweet osmanthus valve, 17 parts of cuckoo petal and cape jasmine petal.
5. the application of the worker bee processing procedure of any one of the claim 1-4 Chinese herbal medicines, it is characterised in that:During the application is
Herbal medicine deep processed product field.
6. the application of the worker bee processing procedure of Chinese herbal medicine according to claim 5, it is characterised in that:The deep processed product
For liquid preparation, ointment, pill, tablet or pulvis.
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