CN108125025A - A kind of functional mineral substance feed addictive with Immune-enhancing effect health-care effect - Google Patents
A kind of functional mineral substance feed addictive with Immune-enhancing effect health-care effect Download PDFInfo
- Publication number
- CN108125025A CN108125025A CN201810025510.2A CN201810025510A CN108125025A CN 108125025 A CN108125025 A CN 108125025A CN 201810025510 A CN201810025510 A CN 201810025510A CN 108125025 A CN108125025 A CN 108125025A
- Authority
- CN
- China
- Prior art keywords
- parts
- feed addictive
- powder
- immune
- mineral substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/28—Silicates, e.g. perlites, zeolites or bentonites
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
Abstract
The present invention provides a kind of functional mineral substance feed addictives with Immune-enhancing effect health-care effect, the technical solution is using attapulgite powder as main component, cooperation yeast cell wall, class take off soil, germanite, tourmaline, kaolinite, montmorillonite and constitute additive formulations, and preferred Ingredient Amount.Wherein core component attapulgite powder is resourceful, and micronutrient levels is comprehensive, and feeding big white mouse progress toxicity test by large dosage shows that attapulgite powder without toxicity, side effect, can ensure edible safety for feed addictive.Practical application finds that animal disease and the death rate can be greatly reduced in the present invention, and nospecific immunity significantly improves, while has good growth promoting function；Moreover, because not adding antibiotic, therefore can play the role of reducing antibiotic dosage；In addition, the animal of application feed addictive of the present invention is promoted, therefore help to improve the product quality of livestock and poultry in the speed of growth, production meat efficiency etc..
Description
Technical field
The present invention relates to field of feed additive technology, further to the improvement of functional feedstuff additive, specifically relate to
And a kind of functional mineral substance feed addictive with Immune-enhancing effect health-care effect.
Background technology
Feed addictive refers to a small amount of or micro substance added during Feed Manufacturing processing, use, in feed
Dosage is seldom but effect is notable.Feed addictive is the raw material that modern feed industry necessarily uses, to strengthening basal feed nutrition
Value improves breeding performonce fo animals, ensures animal health, saving feed cost, and improvement livestock products quality etc. has apparent
Effect.
The feed addictive of the prior art is broadly divided into additive for microbe feedstuff and Chinese herbal feed additive, wherein micro-
Biological feed additive is the biological products being made of one or more fungus strains, can pass through the Tiny ecosystem of its own foundation after taking
Flora forms and inhibits colonizing for harmful bacteria in systematic influence animal body, so as to build good Tiny ecosystem ring for growth of animal
Border.Chinese herbal feed additive is using natural plants or its extract as main component, to adjust animal bodies function, improve generation
Thank to a kind of product for being characterized as main function, since natural plants physical property is mildly provided simultaneously with certain dietotherapy feature, work(
Effect is more extensive.
In addition, mineralogical composition is also a kind of important feed addictive.Trace element be growth of animal indispensable nutrition into
Point, and animal during the fixed feed of long-term consumption since food is relatively single, thus easily lack certain trace elements,
The feed addictive of mineralogical composition is often to improving growth of animal situation, especially immunocompetence with important in this case
Effect.However, as additive, content is very low in feed, and the influence factor for feeding condition is complicated, therefore has in feed addictive
Influence of the body ingredient to overall efficacy is difficult to investigate；Different trace elements are absorbing, converting and then are participating in animal physiological in addition
The principle of process is simultaneously indefinite, therefore in the feed addictive composition design for the purpose of promoting animal immunizing power and does not have
Specific directive property.Also this present situation is based on, conventional feed addictive promotes the immunity of animal in the prior art
Effect urgently improves.
Attapulgite, also known as palygorskite or Palygorskite are a kind of clays of magnesium silicate containing Shuifu County for having chain layer structure
Mineral.Its structure belongs to 2+1 type clay minerals, and in each 2+1 unit structures layer, direction at a certain distance is pushed up at tetrahedron chip angle
Reverse, forming layer chain forms the channel parallel with chain in tetrahedron interband, zeolite water and the crystallization water is filled in channel.It is recessed
Convex stick stone form is in hair-like or fibrous, and usually woollen blanket shape or earthy aggregate, Mohs' hardness are 2~3, are heated to
Hardness at 700~800 DEG C>5, proportion is 2.05~2.32.Since attapulgite has unique crystal structure, with perhaps
Mostly special materialization and processing performance, main physical and chemical performance and processing performance include：Cationic interchangeability, water imbibition, absorption
Decolourising property, big specific surface area (9.6~36m2/ g) and colloid index and expansion capacity.Attapulgite is mainly used in the prior art
In fields such as oil, chemical industry, environmental protection, such as auxiliary agent, catalyst carrier, adsorbent etc., at the same also as refractory coating into
Point, wall lining ingredient, adhesive ingredients, lubricant composition etc. be applied to the fields such as building, machinery.It has no in the prior art recessed
Convex stick stone also has no the feedstuff additive product using attapulgite as core component to the report of animal immunizing power improvement result.
Invention content
The present invention is directed to be directed to the technological deficiency of the prior art, a kind of functionality with Immune-enhancing effect health-care effect is provided
Mineral additive for feed has animal immune facilitation skill to be hoisted to solve conventional feed additive in the prior art
Art problem.
Another technical problem to be solved by the present invention is that health care of the conventional feed additive to growth of animal in the prior art
Effect has to be hoisted.
The invention solves another technical problem be expand feed addictive optional range.
For realization more than technical purpose, the present invention uses following technical scheme：
A kind of functional mineral substance feed addictive with Immune-enhancing effect health-care effect, the feed addictive include following
The ingredient of parts by weight：20~25 parts of attapulgite powder, 5~10 parts of yeast cell wall, class take off 5~8 parts of soil, germanite powder 10~20
Part, 8~10 parts of tourmaline powder, 5~8 parts of kaolinite mountain flour, 19~47 parts of montmorillonite powder.
Preferably, the feed addictive by following weight percent into being grouped as：Attapulgite powder 20~25%, ferment
Mother cell wall 5~10%, class take off soil 5~8%, germanite powder 10~20%, tourmaline powder 8~10%, kaolinite mountain flour 5~8%, illiteracy
De- mountain flour surplus.
Preferably, further include the diatomite of 5~10 parts by weight.
Preferably, further include the Fluorspar Powder of 5~10 parts by weight.
Preferably, further include the mica powder of 5~10 parts by weight.
Preferably, adding proportion of the mineral additive for feed in feed is 2~3% (w/w).
Preferably, the fineness of the mineral additive for feed is 200~350 mesh.
In above technical scheme, the attapulgite powder, germanite powder, tourmaline powder, kaolinite mountain flour, montmorillonite powder, firefly
Mountain flour, the powder that mica powder is corresponding ore, can buy from market；The yeast cell wall, class take off soil, diatomite is routine
Commercial product can also be bought from market.
The present invention provides a kind of functional mineral substance feed addictive with Immune-enhancing effect health-care effect, the technical sides
Case has studied influence of the mineralogical composition to animal growth performance based on laboratory facilities, has investigated a variety of complex minerals on this basis
Raw material is used for the feasibility and conspiracy relation of animal edible, so that it is determined that using attapulgite powder as main component, coordinates yeast
Cell wall, class take off the additive formulations that soil, germanite, tourmaline, kaolinite, montmorillonite are formed, and preferred Ingredient Amount.Its
Middle core component attapulgite powder is resourceful, and micronutrient levels is comprehensive, and feeding big white mouse by large dosage carries out toxicity examination
It tests and shows that attapulgite powder without toxicity, side effect, can ensure edible safety for feed addictive.Practical application is found, of the invention
Animal disease and the death rate can be greatly reduced, nospecific immunity significantly improves, while has good growth promoting function；And
And due to not adding antibiotic, can play the role of reducing antibiotic dosage；In addition, apply feed addictive of the present invention
Animal promoted, therefore help to improve the product quality of livestock and poultry in the speed of growth, production meat efficiency etc..
In addition, the present invention on the basis of above formula the study found that further add diatomite, Fluorspar Powder, mica powder
The element helped to improve in additive is formed, and playing immunologic enhancement for attapulgite powder plays synergy.Meanwhile this
Invention has studied additive amount and additive grain of the additive of the present invention in feed using absorbability and animal metabolism ability as foundation
Degree, finally determines 2~3% additive amount and the granularity of 200~350 mesh, and immunologic enhancement is preferably played for it and is established
Basis.It is normally fed in the use of the present invention, should make an addition in feed, persistently can play definite effect using more than 30d.
Specific embodiment
The specific embodiment of the present invention will be described in detail below.In order to avoid excessive unnecessary details,
It will not be described in detail in following embodiment to belonging to well known structure or function.
Approximating language used in following embodiment can be used for quantitative expression, show in the feelings for not changing basic function
Quantity is allowed to have certain variation under condition.Therefore, it is not limited to this accurately with the modified numerical value of the language such as " about ", " left and right " institute
Numerical value is in itself.In some embodiments, the range for allowing its modified numerical value in positive and negative 10 (10%) " about " is represented
Interior variation, for example, what " about 100 " represented can be any numerical value between 90 to 110.In addition, " the about first numerical value arrives
In the statement of second value ", the first and second numerical value two values are at about corrected.In some cases, approximating language
It may be related with the precision of measuring instrument.
In addition to being defined, technical and scientific term used in following embodiment has and fields technology people of the present invention
The identical meanings that member is commonly understood by.
Embodiment 1
A kind of functional mineral substance feed addictive with Immune-enhancing effect health-care effect, the feed addictive is by following heavy
Amount percentage into being grouped as：Attapulgite powder 20%, yeast cell wall 5%, class take off soil 5%, germanite powder 10%, tourmaline powder
8%, kaolinite mountain flour 5%, montmorillonite powder surplus.
Embodiment 2
A kind of functional mineral substance feed addictive with Immune-enhancing effect health-care effect, the feed addictive is by following heavy
Amount percentage into being grouped as：Attapulgite powder 25%, yeast cell wall 10%, class take off soil 8%, germanite powder 20%, tourmaline
Powder 10%, kaolinite mountain flour 8%, montmorillonite powder surplus.
Embodiment 3
A kind of functional mineral substance feed addictive with Immune-enhancing effect health-care effect, the feed addictive is by following heavy
Amount percentage into being grouped as：Attapulgite powder 23%, yeast cell wall 8%, class take off soil 6%, germanite powder 15%, tourmaline powder
9%, kaolinite mountain flour 7%, montmorillonite powder surplus.
It chooses same batch health, pig 500 similar in weight, is divided into five groups, every group 100, is fed using identical feed
It supports 2 months, every group of pig uses forage feed 3 times daily, one day consumption 2kg feed of every pig, wherein three groups are added implementation respectively
The feed addictive of example 1~3, additive amount account for the 2% of feed relative；Another two groups of one of which do not add feed addictive (blank
Group), another set adds commercially available conventional feed additive (contrast groups).The developmental state of each group pig is as shown in table 1.
1 pig growth and development situation of table
| Group | Incidence (%) | Original body mass (kg) | The weight that averagely increases day by day (kg) |
| Embodiment 1 | 1.2 | 15±1 | 1.0 |
| Embodiment 2 | 1.8 | 15±1 | 1.1 |
| Embodiment 3 | 1.4 | 15±1 | 1.1 |
| Contrast groups | 6.4 | 15±1 | 0.5 |
| Blank group | 8.8 | 15±1 | 0.4 |
It can be found that the blank group of unused feed addictive in terms of incidence or rate of gain by 1 data of table
Aspect is in disadvantage；And compared with having used the contrast groups of conventional commercial feed addictive, feed addictive of the present invention can be bright
It is aobvious to reduce incidence, and prompt the weight that averagely increases day by day.It is possible thereby to prove the present invention to improving animal immune ability, promoting to grow
Aspect has exact effect.
Continue to feed pig using the above method, until when the weight average of one of which increases to 120kg or so, butcher to obtain each
The neat percentage of group pig, as shown in table 2：
The neat percentage of 2 pig of table
| Group | Neat percentage |
| Embodiment 1 | 64.22 |
| Embodiment 2 | 68.57 |
| Embodiment 3 | 63.25 |
| Contrast groups | 58.70 |
| Blank group | 52.25 |
By 2 data of table it can be found that application feed addictive of the present invention not only has facilitation to its immunocompetence, together
When can definitely promote meat productivity, lay a good foundation for the economic value added of Promoting Livestock.
Embodiment 4
A kind of functional mineral substance feed addictive with Immune-enhancing effect health-care effect, the feed addictive is by following heavy
Amount part into being grouped as：20 parts of attapulgite powder, 5 parts of yeast cell wall, class take off soil 5 parts, 10 parts of germanite powder, 8 parts of tourmaline powder,
5 parts of kaolinite mountain flour, 19 parts of montmorillonite powder.
Adding proportion of the mineral additive for feed in feed is 2% (w/w).
Embodiment 5
A kind of functional mineral substance feed addictive with Immune-enhancing effect health-care effect, the feed addictive is by following heavy
Amount part into being grouped as：25 parts of attapulgite powder, 10 parts of yeast cell wall, class take off 8 parts of soil, 20 parts of germanite powder, tourmaline powder 10
Part, 8 parts of kaolinite mountain flour, 47 parts of montmorillonite powder.
The average fineness of the mineral additive for feed is 200 mesh.
Embodiment 6
A kind of functional mineral substance feed addictive with Immune-enhancing effect health-care effect, the feed addictive is by following heavy
Amount part into being grouped as：22 parts of attapulgite powder, 7 parts of yeast cell wall, class take off soil 6 parts, 15 parts of germanite powder, 9 parts of tourmaline powder,
6 parts of kaolinite mountain flour, 33 parts of montmorillonite powder, 5 parts of diatomite, 10 parts of Fluorspar Powder, 5 parts of mica powder.
The average fineness of the mineral additive for feed is 350 mesh.
Embodiment 7
A kind of functional mineral substance feed addictive with Immune-enhancing effect health-care effect, the feed addictive is by following heavy
Amount part into being grouped as：22 parts of attapulgite powder, 7 parts of yeast cell wall, class take off soil 6 parts, 15 parts of germanite powder, 9 parts of tourmaline powder,
6 parts of kaolinite mountain flour, 33 parts of montmorillonite powder, 10 parts of diatomite, 10 parts of mica powder.
Embodiment 8
A kind of functional mineral substance feed addictive with Immune-enhancing effect health-care effect, the feed addictive is by following heavy
Amount part into being grouped as：22 parts of attapulgite powder, 7 parts of yeast cell wall, class take off soil 6 parts, 15 parts of germanite powder, 9 parts of tourmaline powder,
6 parts of kaolinite mountain flour, 33 parts of montmorillonite powder, 5 parts of Fluorspar Powder.
The embodiment of the present invention is described in detail above, but the content is only presently preferred embodiments of the present invention,
It is not intended to limit the invention.All all any modification, equivalent and improvement done in the application range of the present invention etc., should all
It is included within protection scope of the present invention.
Claims (7)
- A kind of 1. functional mineral substance feed addictive with Immune-enhancing effect health-care effect, it is characterised in that the feed addictive Include the ingredient of following parts by weight：20~25 parts of attapulgite powder, 5~10 parts of yeast cell wall, class take off 5~8 parts of soil, germanite powder 10~20 parts, 8~10 parts of tourmaline powder, 5~8 parts of kaolinite mountain flour, 19~47 parts of montmorillonite powder.
- 2. a kind of functional mineral substance feed addictive with Immune-enhancing effect health-care effect according to claim 1, It is characterized in that the feed addictive by following weight percent into being grouped as：Attapulgite powder 20~25%, yeast cell wall 5 ~10%, class takes off soil 5~8%, germanite powder 10~20%, tourmaline powder 8~10%, kaolinite mountain flour 5~8%, more than montmorillonite powder Amount.
- 3. a kind of functional mineral substance feed addictive with Immune-enhancing effect health-care effect according to claim 1, It is characterized in that further including the diatomite of 5~10 parts by weight.
- 4. a kind of functional mineral substance feed addictive with Immune-enhancing effect health-care effect according to claim 1, It is characterized in that further including the Fluorspar Powder of 5~10 parts by weight.
- 5. a kind of functional mineral substance feed addictive with Immune-enhancing effect health-care effect according to claim 1, It is characterized in that further including the mica powder of 5~10 parts by weight.
- 6. a kind of functional mineral substance feed addictive with Immune-enhancing effect health-care effect according to claim 1 or 2, It is characterized in that adding proportion of the mineral additive for feed in feed is 2~3% (w/w).
- 7. a kind of functional mineral substance feed addictive with Immune-enhancing effect health-care effect according to claim 1 or 2, It is characterized in that the fineness of the mineral additive for feed is 200~350 mesh.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810025510.2A CN108125025A (en) | 2018-01-11 | 2018-01-11 | A kind of functional mineral substance feed addictive with Immune-enhancing effect health-care effect |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810025510.2A CN108125025A (en) | 2018-01-11 | 2018-01-11 | A kind of functional mineral substance feed addictive with Immune-enhancing effect health-care effect |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108125025A true CN108125025A (en) | 2018-06-08 |
Family
ID=62399743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810025510.2A Pending CN108125025A (en) | 2018-01-11 | 2018-01-11 | A kind of functional mineral substance feed addictive with Immune-enhancing effect health-care effect |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108125025A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1810145A (en) * | 2006-01-19 | 2006-08-02 | 王傲乾 | Production process of natural mineral feed additive |
| CN101637221A (en) * | 2009-08-27 | 2010-02-03 | 平湖市畜牧兽医局 | Feed additive for promoting livestock growth and preparation method thereof |
| CN103027197A (en) * | 2013-01-06 | 2013-04-10 | 杭州世博生物技术开发研究所有限公司 | Mineral feed additive containing nano-selenium and preparation method and applications thereof |
| CN104161195A (en) * | 2013-10-29 | 2014-11-26 | 天津威隆动物药品有限公司 | Feed additive with natural minerals |
| CN104855691A (en) * | 2015-06-15 | 2015-08-26 | 江苏益客食品有限公司 | Anti-mycotoxin feed additive for ducks as well as preparation method and application of anti-mycotoxin feed additive |
| CN107095007A (en) * | 2017-03-29 | 2017-08-29 | 安徽省微科生物科技有限公司 | A kind of fattening feed fattened for 5 monthly age sheep of high-density breeding |
-
2018
- 2018-01-11 CN CN201810025510.2A patent/CN108125025A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1810145A (en) * | 2006-01-19 | 2006-08-02 | 王傲乾 | Production process of natural mineral feed additive |
| CN101637221A (en) * | 2009-08-27 | 2010-02-03 | 平湖市畜牧兽医局 | Feed additive for promoting livestock growth and preparation method thereof |
| CN103027197A (en) * | 2013-01-06 | 2013-04-10 | 杭州世博生物技术开发研究所有限公司 | Mineral feed additive containing nano-selenium and preparation method and applications thereof |
| CN104161195A (en) * | 2013-10-29 | 2014-11-26 | 天津威隆动物药品有限公司 | Feed additive with natural minerals |
| CN104855691A (en) * | 2015-06-15 | 2015-08-26 | 江苏益客食品有限公司 | Anti-mycotoxin feed additive for ducks as well as preparation method and application of anti-mycotoxin feed additive |
| CN107095007A (en) * | 2017-03-29 | 2017-08-29 | 安徽省微科生物科技有限公司 | A kind of fattening feed fattened for 5 monthly age sheep of high-density breeding |
Non-Patent Citations (5)
| Title |
|---|
| 严莲荷主编: "《水处理药剂及配方手册》", 31 January 2004, 中国石化出版社 * |
| 兰旅涛主编: "《农村养猪实用技术》", 31 October 2009, 江西科学技术出版社 * |
| 张庆麟主编: "《珠宝玉石识别辞典 第2版》", 31 August 2013, 上海科学技术出版社 * |
| 徐春厚主编: "《微生物饲料与添加剂》", 31 March 2000, 黑龙江人民出版社 * |
| 王桂馥主编: "《畜禽养殖生产管理学》", 30 April 1988, 中国人民解放军兽医大学训练部出版 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102934734B (en) | Composite goose feed for summer, and preparation method thereof | |
| CN101548725B (en) | Compound premix for reserved layer chickens | |
| CN105767477A (en) | Compound premixed feed | |
| CN104839498B (en) | A kind of DHA adjusting control agents and its chicken feed | |
| CN103719606A (en) | Feed for breeding rabbits | |
| CN102150753A (en) | Medical stone salt block feed additive and preparation method thereof | |
| CN104905024A (en) | Nutrient additive for promoting growth of bird species | |
| CN101411409B (en) | Ecological bait for mixed culture of Exopalamon carincauda Holthuis and Portunus trituberculatus and preparation method thereof | |
| CN108125025A (en) | A kind of functional mineral substance feed addictive with Immune-enhancing effect health-care effect | |
| CN202476246U (en) | Hutch provided with licking brick | |
| CN111213790A (en) | High-efficiency feed additive | |
| CN107198050A (en) | A kind of vegetarian diet dog chew | |
| CN103918912B (en) | A kind of quick improve boar limb hoof health concentrate feed, preparation method and application | |
| CN107927344A (en) | A kind of functionalization nutrition lap brick and preparation method thereof | |
| CN106616031A (en) | Formula of feed for carps in growth period | |
| CN106605790A (en) | Feed formula for promoting egg laying of laying hens | |
| KR101851994B1 (en) | Live mineral block and method of preparing the same | |
| CN102578377A (en) | Licking block, preparation method of same and fence being furnished with licking block | |
| CN109221818A (en) | A kind of feed addictive enhancing perch nutrition | |
| CN107981057A (en) | A kind of composite nutrient licking brick and preparation method thereof | |
| CN107594151A (en) | A kind of fattening feed of the disconnected goat of 60 age in days | |
| CN108125064A (en) | A kind of soft-shelled turtle feed and preparation method thereof | |
| CN106912736A (en) | A kind of pigeon racing granule premix and preparation method thereof | |
| CN106721650A (en) | A kind of feed addictive of carp | |
| CN106721646A (en) | A kind of feed addictive of crucian |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180608 |
|
| RJ01 | Rejection of invention patent application after publication |