CN108114114A - 一种治疗跌打损伤的胶囊剂药物及制备方法 - Google Patents

一种治疗跌打损伤的胶囊剂药物及制备方法 Download PDF

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CN108114114A
CN108114114A CN201810036587.XA CN201810036587A CN108114114A CN 108114114 A CN108114114 A CN 108114114A CN 201810036587 A CN201810036587 A CN 201810036587A CN 108114114 A CN108114114 A CN 108114114A
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夏瑜
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Abstract

本发明属于中药制剂领域，目的是根据中医治疗跌打损伤的认识机理而提供一种治疗跌打损伤的胶囊剂药物，所述药物的各个组分及其质量份比如下：血竭10～35g、肉桂20～70g、制乳香30～70g、木香15～70g、没药50～260g、闹羊花3～6g、红花50～120g、羌活100～300g、儿茶10～45g、紫荆皮60～180g、冰片2～6g、五加皮60～100g、藿香50～160g、牡丹皮60～100g、乌药30～100g；本发明提供的药物是一个很好的中药组方。

Description

一种治疗跌打损伤的胶囊剂药物及制备方法
技术领域
本发明属于中药制剂领域，具体涉及一种治疗跌打损伤的胶囊剂药物，特别是供跌打损伤患者使用的胶囊剂药物及制备方法的领域。
背景技术
祖国医学认为，跌打损伤包括刀枪、跌仆、殴打、闪挫、刺伤、擦伤、运动损伤等，伤处多有疼痛、肿胀、出血或骨折、脱臼等，也包括一些内脏损伤。在此主要以软组织损伤为主。
在日常生活中对于有些人似乎是家常便饭，泛指人因跌、打、碰、磕等原因所致的软组织损伤，以肿胀、疼痛为主要表现。有些人发生跌打损伤后，急于诊治，往往使用药物熏洗，其实有时候这样做极易事与愿违。不但没有疗效，反而病情会越来越严重。
那么，就如何找到一种可有效治疗跌打损伤的中药组合物，是本领域技术人员亟待要解决的问题。
发明内容
随着我国中医中药学的不断发展，在治疗跌打损伤上，人们逐渐意识到了中医治疗跌打损伤的优点，且在治疗过程中疗效好、见效快、毒副作用小等优势，针对现有西医治疗跌打损伤的现状，本发明的目的是在于提供一种治疗跌打损伤的胶囊剂药物，以解决跌打损伤患者早日恢复健康的问题。该药物是以常见的中药为原料，通过选择合理的药物及质量份比，可有效治疗上述跌打损伤。
为达到上述发明的目的，本发明所采用的技术方案为：提供一种治疗跌打损伤的胶囊剂药物及制备方法，其特征在于，所述药物的各个组分及质量份比如下所示：
血竭10～35g、肉桂20～70g、制乳香30～70g、木香15～70g、没药50～260g、闹羊花3～6g、红花50～120g、羌活100～300g、儿茶10～45g、紫荆皮60～180g、冰片2～6g、五加皮60～100g、藿香50～160g、牡丹皮60～100g、乌药30～100g，辅料：微粉硅胶、微晶纤维素和淀粉适量。
一种治疗跌打损伤的胶囊剂药物及制备方法，其特征在于，所述药物的各个组分及质量份比如下所示：
血竭11～31g、肉桂26～60g、制乳香36～60g、木香18～60g、没药56～230g、闹羊花4～5.5g、红花56～105g、羌活115～260g、儿茶12～40g、紫荆皮70～160g、冰片3～5.5g、五加皮70～90g、藿香56～140g、牡丹皮70～90g、乌药35～90g，辅料：微粉硅胶、微晶纤维素和淀粉适量。
一种治疗跌打损伤的胶囊剂药物及制备方法，其特征在于，所述药物的各个组分及质量份比如下所示：
血竭28g、肉桂52g、制乳香52g、木香52g、没药200g、闹羊花5g、红花95g、羌活230g、儿茶35g、紫荆皮140g、冰片5g、五加皮80g、藿香120g、牡丹皮80g、乌药80g，辅料：微粉硅胶、微晶纤维素和淀粉适量。
一种治疗跌打损伤的胶囊剂药物及制备方法，其特征在于，所述方法包括如下步骤制备而成：
A、除血竭和冰片(分别研末)外,将上述其它原料中药拣去杂质和粉尘后，按照质量份比共粉碎成（30～50目）颗粒状包煎；
B、①将包好的原料中药放入冷开水中浸泡50min，然后再将浸泡好的药物放入砂锅内，加入原料中药重量8～10倍的冷开水进行第一次武火煎煮，待煎煮到18min时，转文火熬制120min，滤取药液；②药渣中再次加入原料中药重量7～9 倍的冷开水进行第二次武火煎煮，待煎煮到15min时，转文火熬制110min，滤取药液；③将二次药液混合浓缩成相对密度为1.08 的清膏，然后干燥、研末和消毒后备用；
C、①按照传统制备中药胶囊剂的方法，将A和B中研磨好的细末过筛后，加入适量的微粉硅胶、微晶纤维素和淀粉混合均匀，然后制备成胶囊剂（其胶囊锁合后总长度为23.3mm，药粉容量0.4～0.5g/粒），②继而抛光，消毒，分装密封即可。
一种治疗跌打损伤的胶囊剂药物及制备方法，其特征在于，所述服用方法为：将制备好的胶囊剂药物以每日三次服用，早中晚各服一次，给药量2.4g（6粒）/次，温开水送服。10天为一个疗程，服药1～2个疗程，症状全部消失，病告痊愈。
本发明组方中的各原料中药在中国药典、中国辞典以及中华本草中均有详细的记载。本发明选用其中最常见的中药为原料，充分发挥各组分的药理功效：
血竭，性味：甘、咸、平，具有祛瘀定痛、止血生肌之功效，用于治疗跌扑折损、内伤瘀痛、外伤出血不止；
肉桂，性味：辛、甘、热，具有补火助阳、引火归源、散寒止痛、温经通脉之功效，用于治疗肾阳不足、命门火畏寒肢冷、腰膝酸软、阳痿遗精、小便不利或频数、短气喘促、浮肿尿少诸证、命门 火衰、火不归源、戴阳、格阳、及上热下寒、面赤足冷、头晕耳鸣、口舌糜破、脾肾虚寒、脘腹冷痛、食减便溏、肾虚腰痛、寒湿痹痛、寒疝疼痛、宫冷不孕、痛经经闭、产后瘀滞腹痛、阴疽流注、或虚寒痈疡脓成不溃、或溃后不敛；
制乳香，性味：辛、苦、温，具有活血行气止痛、消肿生肌之功效，用于治疗胸痹心痛、胃脘疼痛、痛经经闭、产后瘀阻、症瘕腹痛、风湿痹痛、筋脉拘挛、跌打损伤、痈肿疮疡；
木香,性味：辛、苦、温，具有行气止痛、健脾消食之功效，用于治疗胸脘胀痛、泻痢后重、食积不消、不思饮食，煨木香实肠止泻，用于泄泻腹痛；
没药，性味：苦、平，具有散瘀止痛，外用消肿生肌之功效，用于治疗跌打淤血肿痛、痈疽肿痛、胸腹诸痛，外用治疮口久不收敛；
闹羊花，性味：味辛、性温，有毒，具有驱风、除湿、定痛之功效，用于治疗风湿顽痹、伤折疼痛、皮肤顽癣，并用作手术麻醉；
红花，性味：味辛、性温，具有活血能经、祛瘀止痛之功效，用于治疗经闭、痛经、产后瘀阻腹痛、胞痹心痛症瘕积聚、跌打损伤、关节疼痛、中风偏竣、斑疹等症；
羌活，性味：辛苦、温，具有散表寒、祛风湿、利关节之功效，用于治疗感冒风寒、头痛无汗、风寒湿痹、项强筋急、骨节酸疼、风水浮肿、痈疽疮毒；
儿茶，性味：苦、涩、微寒，具有活血止痛、止血生肌、收湿敛疮、清肺化痰之功效，用于治疗跌扑伤痛、外伤出血、吐血衄血、疮疡不敛、湿疹、湿疮、肺热咳嗽；
紫荆皮，性味：味苦、性平，具有活血、通淋、解毒之功效，用于治疗妇女月经不调、瘀滞腹痛、风湿痹痛、小便淋痛、喉痹、痈肿、疥癣、跌打损伤、蛇虫咬伤；
冰片，性味：辛、苦、微寒，具有开窍醒神、清热止痛之功效，用于治疗热病神昏、惊厥、中风痰厥、气郁暴厥、中恶昏迷、胸痹心痛、目赤、口疮、咽喉肿痛、耳道流脓；
五加皮，性味：味辛、苦、微甘、性温，具有祛风湿、补肝肾、强筋骨、活血脉之功效，用于治疗风寒湿痹、腰膝疼痛、筋骨痿软、小数点儿行迟、体虚赢弱、跌打损伤、骨折、水肿、脚气、阴下湿痒等症；
藿香，性味：味辛、性温，具有化湿醒脾、辟秽和中、解暑、发表之功效，用于治疗湿阻脾胃、脘腹胀满、湿温初起、呕吐、泄泻、暑湿、发热恶寒、恶寒发热、胸脘满闷；
牡丹皮，性味：辛苦、凉、微寒，具有清热、活血散瘀之功效，用于治疗温热病热入血分、发斑、吐衄、热泪盈眶病菌后期热伏阴分发热、阴虚骨蒸潮热、血滞经闭、痛经、痈肿疮毒、跌扑伤痛、风湿热痹等症；
乌药，性味：辛、温，具有顺气止痛、温肾散寒之功效，用于治疗胸腹胀痛、气逆喘急、膀胱虚冷、遗尿尿频、疝气、痛经等症。
本发明药物是基于中医治疗跌打损伤的原则，从依据跌打损伤的病理机制及药理作用认为：就跌打损伤，本发明所提供的药物中的各原料中药药效共奏，对上述疾病有很好的治疗效果。
具体实施方式
本发明就是针对上述跌打损伤的治疗而提出的一种中药配方，采用该配方制备的药物药效好，见效快，是一个很好的中药组方，特别适合临床使用。下面结合本发明的具体实施方式作进一步详细的描述：
实施例1：
一种治疗跌打损伤的胶囊剂药物，其特征在于，所述药物的各个组分及质量份比如下所示：
血竭28g、肉桂52g、制乳香52g、木香52g、没药200g、闹羊花5g、红花95g、羌活230g、儿茶35g、紫荆皮140g、冰片5g、五加皮80g、藿香120g、牡丹皮80g、乌药80g，辅料：微粉硅胶、微晶纤维素和淀粉适量。
实施例2：
一种治疗跌打损伤的胶囊剂药物，其特征在于，所述药物的各个组分及质量份比如下所示：
血竭31g、肉桂60g、制乳香60g、木香60g、没药230g、闹羊花5.5g、红花105g、羌活260g、儿茶40g、紫荆皮160g、冰片5.5g、五加皮90g、藿香140g、牡丹皮90g、乌药90g，辅料：微粉硅胶、微晶纤维素和淀粉适量。
实施例3：
一种治疗跌打损伤的胶囊剂药物，其特征在于，所述药物的各个组分及质量份比如下所示：
血竭35g、肉桂70g、制乳香70g、木香70g、没药260g、闹羊花6g、红花120g、羌活300g、儿茶45g、紫荆皮180g、冰片6g、五加皮100g、藿香160g、牡丹皮100g、乌药100g，辅料：微粉硅胶、微晶纤维素和淀粉适量。
典型病例：
经临床诊断治疗跌打损伤患者共1265例，年龄为39岁以上的645例，只有620例为39岁以下。1265例患者中痊愈的有927例，有效的281例，无效的57例。总有效率达95.5%。

Claims (3)

1.一种治疗跌打损伤的胶囊剂药物，其特征在于，所述药物的各个组分及质量份比如下所示：
血竭10～35g、肉桂20～70g、制乳香30～70g、木香15～70g、没药50～260g、闹羊花3～6g、红花50～120g、羌活100～300g、儿茶10～45g、紫荆皮60～180g、冰片2～6g、五加皮60～100g、藿香50～160g、牡丹皮60～100g、乌药30～100g，辅料：微粉硅胶、微晶纤维素和淀粉适量。
2.根据权利要求1所述的治疗跌打损伤的胶囊剂药物，其特征在于，所述药物的各个组分及质量份比如下所示：
血竭11～31g、肉桂26～60g、制乳香36～60g、木香18～60g、没药56～230g、闹羊花4～5.5g、红花56～105g、羌活115～260g、儿茶12～40g、紫荆皮70～160g、冰片3～5.5g、五加皮70～90g、藿香56～140g、牡丹皮70～90g、乌药35～90g，辅料：微粉硅胶、微晶纤维素和淀粉适量。
3.根据权利要求1至2所述的治疗跌打损伤的胶囊剂药物，其特征在于，所述药物的各个组分及质量份比如下所示：
血竭28g、肉桂52g、制乳香52g、木香52g、没药200g、闹羊花5g、红花95g、羌活230g、儿茶35g、紫荆皮140g、冰片5g、五加皮80g、藿香120g、牡丹皮80g、乌药80g，辅料：微粉硅胶、微晶纤维素和淀粉适量。
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