CN108078570B - A dynamic blood glucose monitoring circuit with built-in acceleration sensor and control method thereof - Google Patents

Abstract

A dynamic blood sugar monitoring circuit with an embedded acceleration sensor and a control method thereof relate to wearable equipment used in the medical detection field and a control method thereof, and are formed by connecting a blood sugar sensor component with an embedded blood sugar sensor with a transmitter component; the transmitter assembly comprises a sensor excitation module, a sampling conditioning module, an ADC module, a wireless SoC module and a flash memory module, and is formed by connecting a blood glucose sensor assembly with a built-in blood glucose sensor with the transmitter assembly; the transmitter assembly comprises a sensor excitation module, a sampling conditioning module, an ADC module, a wireless SoC module and a flash memory module, can acquire the movement and sleep information of a wearer through a triaxial acceleration sensor while continuously acquiring and recording the blood sugar of a human body, provides the recognition and wake-up self-rescue of hypoglycemia coma, and transmits blood sugar monitoring data to intelligent handheld equipment or other external receiving terminals with wireless receiving and transmitting functions in a wireless transmission mode for data display analysis and remote alarm help seeking service.

Description

A dynamic blood glucose monitoring circuit with built-in acceleration sensor and control method thereof

Technical Field

The present invention relates to a wearable device and a control method thereof used in the field of medical detection, and in particular to an electronic circuit and a wearable device thereof for dynamic blood sugar measurement and motion posture detection.

Background technique

Blood glucose monitoring is an important part of diabetes management. The results of blood glucose monitoring help assess the degree of glucose metabolism disorders in diabetic patients, specify glucose-lowering plans, and show the effect of treatment and guide the adjustment of treatment plans. Blood glucose concentration is related to many factors, such as exercise, diet, medication, etc. The traditional blood glucose monitoring method is to collect finger blood for monitoring, but this method cannot reflect the patient's blood glucose profile throughout the day, and there is a monitoring blind spot. Therefore, in recent years, a dynamic blood glucose monitoring product has been developed that can achieve all-day blood glucose monitoring. For example, the Chinese invention patent application "Implantable Low-Power Wireless Blood Glucose Monitor" (invention patent application number: 201410277574.3, publication number: CN104055525A) discloses an implantable low-power wireless blood glucose monitor, including an in vivo implant component and an in vitro component, the in vivo implant component includes an implantable glucose sensor, the implantable glucose sensor is connected to a signal processing circuit, the signal processing circuit is connected to a microprocessor, the microprocessor is connected to a first wireless communication module, the implantable glucose sensor, the signal processing circuit, the microprocessor and the first wireless communication module are all connected to a power supply module, the signal processing circuit, the microprocessor, the wireless communication module and the power supply module are all enclosed in a shell; the in vitro component includes a second wireless communication module and a host computer, the second wireless communication module is connected to the host computer. The Chinese utility model patent "A wireless, real-time blood glucose recorder" (utility model patent number: ZL201520192338.1 authorization announcement number: CN204618248U) discloses a wireless, real-time blood glucose recorder, which is mainly composed of a monitoring terminal and an APP terminal. The monitoring terminal includes a glucose sensing probe and a wireless data transmitter; the wireless data transmitter is connected to the glucose sensing probe and transmits the blood glucose data provided by the glucose sensing probe to the APP terminal; the APP terminal can analyze the blood glucose data and display the blood glucose concentration on the APP terminal screen. When the glucose sensing probe detects an electric current, the wireless data transmitter sends the electrical signal value to the APP terminal at a short distance. The APP terminal can analyze the blood glucose data and display the blood glucose concentration on the APP terminal screen, generate a data curve, and give the correct insulin dosage. This technical solution can realize 24-hour real-time monitoring of blood glucose concentration; through wireless transmission, it can effectively solve the problem of probe loosening due to the low implantation subcutaneously; through APP terminal data processing, it can also effectively solve the problem of inconvenient carrying and easy damage of the equipment.

Although the above-mentioned prior art solutions solve the problem of continuous real-time detection of blood sugar and realize dynamic monitoring of blood sugar levels in diabetic patients. However, such dynamic blood sugar products have a single function and can only be used to monitor human blood sugar. And information related to blood sugar, such as exercise, diet, and medication, can only be recorded manually. China's utility model patent "Wireless Blood Glucose Pedometer" (utility model patent number: ZL201220166396.3 authorization announcement number: CN202568265U) discloses a blood sugar pedometer with wireless transmission function. The power module is connected to the keyboard module and the display module respectively through the main control module, and the main control module is connected to the blood sugar measurement module, the step module wireless transmission module and the storage module respectively, and the power module supplies power to the above modules. Step counting and blood sugar monitoring data are recorded simultaneously, and the data is wirelessly sent to the host computer for storage and analysis at intervals of one day or one week. Simultaneously monitoring blood sugar values and exercise volume, and having a wireless transmission function, is not only conducive to the user's long-term monitoring and tracking of blood sugar values, but also can formulate exercise therapy for diabetic patients and their high-risk groups by analyzing the relationship between blood sugar and exercise volume, thereby delaying or reducing the occurrence of diabetes and its complications.

Although the above-mentioned existing technical solutions have respectively solved certain technical problems of blood sugar level and exercise volume monitoring, these existing technical solutions all adopt the method of performing blood sugar detection at preset time intervals, and the step counting module therein simply integrates the function of the pedometer into the blood glucose meter to realize the wearer's exercise volume recording, and does not reflect the mutual support between the two functions.

On the other hand, hypoglycemia coma is the most common and important complication in the treatment of diabetes. Hypoglycemia coma is caused by the patient falling into a coma when the venous plasma glucose concentration is lower than 2.8mmol/L (50mg/dl). With the increasing number of diabetic patients and the aging of the population, the number of elderly patients with hypoglycemia coma has increased year by year. According to statistics from the emergency department of a certain hospital over the past five years, 9%-12% of the elderly comatose patients visited the emergency department. Some of these patients received timely treatment due to early diagnosis and treatment, while others were delayed in treatment due to untimely discovery and treatment, resulting in irreversible brain damage or even death. Therefore, hypoglycemia coma must be treated urgently, and there is an urgent need for a wearable smart device that can meet the care needs of diabetic patients.

Summary of the invention

The purpose of the present invention is to provide a dynamic blood glucose monitoring circuit with a built-in acceleration sensor, which can obtain the wearer's exercise and sleep information while continuously collecting and recording human blood glucose, provide recognition and awakening self-rescue for hypoglycemia coma, and send blood glucose monitoring data to an intelligent handheld device or other host computer terminal with wireless transceiver function by wireless transmission, so as to perform data display analysis and remote alarm and rescue services.

The technical solution adopted by the present invention to solve the above technical problems is:

A dynamic blood glucose monitoring circuit with a built-in acceleration sensor is composed of a blood glucose sensor component with a built-in blood glucose sensor and a transmitter component connected together; the transmitter component includes a sensor excitation module, a sampling and conditioning module, an ADC module, a wireless SoC module and a flash memory module, the sensor excitation module is connected to the blood glucose sensor to provide voltage excitation for it, the current signal output by the blood glucose sensor is converted into a voltage signal by the sampling and conditioning module, and then converted into a digital signal by the ADC module and transmitted to the wireless SoC module, and the blood glucose concentration value is calculated by operation and stored in the flash memory module, or sent to an external receiving terminal through a wireless connection, characterized in that:

The transmitter assembly also includes an acceleration sensor module and a motor wake-up alarm module;

The acceleration sensor module is connected to the wireless SoC module, and the wireless SoC module collects acceleration data through the acceleration sensor module, extracts the posture measurement characteristics and motion statistical characteristics of the wearer through data processing, and obtains the movement and sleep information of the human body;

The motor wake-up alarm module is connected to the wireless SoC module. When the wearer is found to be at risk of hypoglycemia coma, the dynamic blood glucose monitoring circuit starts the wake-up self-rescue through the motor wake-up alarm module and sends a hypoglycemia coma distress signal through an external receiving terminal.

A preferred technical solution of the dynamic blood glucose monitoring circuit with a built-in acceleration sensor of the present invention is characterized in that the blood glucose sensor component and the transmitter component adopt a detachable structure, all circuit components of the transmitter component are sealed and packaged with biocompatible materials, and the contacts V+, V-, S+, S- of the connecting part are left on the outside of the sealed package for connecting the blood glucose sensor component; the blood glucose sensor component and the transmitter component are connected through the connecting part to form a wearable blood glucose transmitter for dynamic blood glucose monitoring.

A better technical solution of the dynamic blood glucose monitoring circuit with built-in acceleration sensor of the present invention is characterized in that the transmitter component also includes a battery charging module, a lithium battery and a power management module; a switching element is connected between the contacts V'+ and V'- of the connecting part of the blood glucose sensor component; when the connecting part between the transmitter component and the blood glucose sensor component is disconnected, the contacts V+ and V- of the connecting part constitute the charging input end of the transmitter component, and the charging voltage can be connected to charge the lithium battery through the battery charging module; when the charging of the transmitter component is completed and the charging voltage is removed but the blood glucose sensor component is not connected, the lithium battery of the transmitter component is disconnected from the inside of the power management module, and each circuit module connected to the power supply output end of the power management module is in a power-off state; when blood glucose monitoring is required, the built-in blood glucose sensor of the blood glucose sensor component is connected to the transmitter component through the contacts S+ and S- of the connecting part, the lithium battery is connected to the power management module through the switching element inside the blood glucose sensor component, and each circuit module of the transmitter component is powered on and starts working.

An improved technical solution of a dynamic blood glucose monitoring circuit with a built-in acceleration sensor of the present invention is characterized in that the switching element is a PCB short-circuit line connected between the contacts V’+ and V’- of the connecting part.

A further improved technical solution of the dynamic blood glucose monitoring circuit with a built-in acceleration sensor of the present invention is characterized in that the switching element is a touch switch connected between the contacts V’+ and V’- of the connecting part, and the switching element is in a negative logic mode. When the switching element is disconnected, the blood glucose transmitter is powered on and works; when the switching element is closed, the blood glucose transmitter loses power and stops working, and the transmitter remains in a power-off state; by closing and re-disconnecting the switching element, a power-on reset operation of the wireless SoC module is achieved.

Another object of the present invention is to provide a dynamic blood glucose monitoring control method for the above-mentioned dynamic blood glucose monitoring circuit, the technical solution adopted is:

A dynamic blood glucose monitoring control method for the above-mentioned dynamic blood glucose monitoring circuit is characterized by comprising the following steps:

S100: Collection and preprocessing of dynamic blood glucose concentration detection data;

S200: Collection of human posture data and behavioral action recognition;

S300: Identification and awakening of hypoglycemia coma, self-rescue and alarm for help;

S400: Wireless transmission of blood glucose monitoring data.

A preferred technical solution of the dynamic blood glucose monitoring control method of the present invention is characterized in that step S100 includes the following actions:

S110: blood glucose transmitter is powered on and initialized;

S120: The built-in Bluetooth BLE module of the blood glucose transmitter establishes a data communication connection with the mobile phone APP terminal via Bluetooth BLE;

S130: Start the blood glucose sensor, write the current time to the blood glucose transmitter, and synchronize the blood glucose sampling cycle;

S140: The blood glucose transmitter applies a predetermined voltage to stimulate the blood glucose sensor;

S150: The blood glucose sensor enters the polarization waiting time; after the polarization is completed, the mobile phone APP terminal writes the reference blood glucose into the blood glucose sensor;

S160: The blood glucose transmitter starts to collect the current signal in the blood glucose sensor, and after being conditioned by the sampling and conditioning module, the current signal is sampled and converted into a digital signal by the ADC module and transmitted to the wireless SoC module, and then calculated and converted into a blood glucose value representing the blood glucose concentration;

S170: The built-in Bluetooth BLE module sends the blood sugar value to the mobile phone APP terminal via Bluetooth.

A better technical solution of the dynamic blood glucose monitoring control method of the present invention is characterized by:

The step S200 includes the following actions:

S210: The blood glucose transmitter reads the three-axis acceleration detection data through the acceleration sensor;

S220: Perform posture analysis and human motion recognition based on the three-axis acceleration detection data, and send the wearer's posture or motion status to the mobile phone APP terminal;

S230: If the recognition result is a walking or running state, collect and send the wearer's motion data to the mobile phone APP terminal, and the motion data at least includes the number of walking or running steps;

S240: If the identification result is a fall event of the wearer, a fall alarm distress signal is sent to a remote APP terminal via the mobile phone APP terminal;

The step S300 includes the following actions:

S310: If the recognition result is coma or sleep state, go to step S320; otherwise, return to step S210;

S320: If the blood sugar monitoring result is hypoglycemia, it is determined that the wearer is at risk of hypoglycemia coma, and the process goes to step S330; otherwise, the process goes back to step S210;

S330: starting the wake-up self-rescue service through the motor wake-up alarm module built into the blood glucose transmitter;

S340: If awakening and self-rescue is effective, return to step S210; otherwise, send a low-sugar coma distress signal to a remote APP terminal via the mobile phone APP terminal.

An improved technical solution of the dynamic blood glucose monitoring control method of the present invention is characterized in that step S400 includes the following actions:

S410: The blood glucose transmitter determines the connection status. If the Bluetooth connection is in the connection status, go to step S420. Otherwise, return to wait for the blood glucose transmitter and the mobile phone APP terminal to re-establish the connection. Since the blood glucose signal cannot be sent to the mobile phone APP terminal in real time at this time, the collected blood glucose value is usually temporarily stored in the flash memory module of the SOC.

S420: The mobile phone APP terminal first queries and reads historical data from the flash memory module;

S430: If all historical data have been sent, the real-time sending state is entered, and the blood glucose transmitter sends the latest collected blood glucose monitoring data to the mobile phone APP terminal.

The beneficial effects of the present invention are:

1. The dynamic blood glucose monitoring circuit with built-in acceleration sensor and its control method of the present invention can continuously collect and record human blood glucose, obtain the wearer's movement and sleep information through the three-axis acceleration sensor, provide recognition and awakening self-rescue of hypoglycemia coma, and send the blood glucose monitoring data to an intelligent handheld device or other external receiving terminal with wireless transceiver function by wireless transmission, so as to perform data display analysis and remote alarm and rescue services.

2. The dynamic blood glucose monitoring circuit with built-in acceleration sensor and the control method thereof of the present invention place the motor wake-up alarm module in the transmitter component of the blood glucose transmitter and wear it directly on the human body; when a dangerous blood glucose signal is detected, even if it is separated from the wireless receiver, the blood glucose transmitter can still directly send an alarm that can be perceived by the human body through the motor wake-up alarm module, thereby improving the reliability of the wake-up self-rescue function.

3. In the dynamic blood glucose monitoring circuit with built-in acceleration sensor of the present invention, the blood glucose sensor component and the transmitter component adopt a detachable structure, which separates the disposable blood glucose sensor component from the reusable transmitter component. The transmitter component can be reused after charging, which can greatly save costs. The blood glucose monitoring data is transmitted to the mobile phone APP terminal by wireless transmission, and blood glucose monitoring and statistical analysis are realized through the mobile phone APP terminal software, which can omit the cost of the dedicated blood glucose monitoring terminal and further reduce the medical burden of patients.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG1 is a circuit block diagram of a dynamic blood glucose monitoring circuit with a built-in acceleration sensor of the present invention;

FIG2 is a schematic diagram of the structure of a dynamic blood glucose monitor directly monitored by a mobile phone APP of the present invention;

FIG3 is a block diagram of the mobile phone APP functional modules of the dynamic blood glucose monitor directly monitored by the mobile phone APP;

FIG4 is a flow chart of a control method for a dynamic blood glucose monitoring circuit with a built-in acceleration sensor according to the present invention;

FIG5 is a flow chart of dynamic blood glucose concentration detection data collection and processing;

FIG6 is a control flow chart of human posture detection, behavior recognition and wake-up rescue;

FIG7 is a flow chart of wireless transmission of blood glucose monitoring data;

FIG8 is a battery charging module of a dynamic blood glucose monitoring circuit with a built-in acceleration sensor of the present invention;

FIG9 is a power management module of a dynamic blood glucose monitoring circuit with a built-in acceleration sensor according to the present invention;

FIG10 is a blood glucose collection circuit of a dynamic blood glucose monitoring circuit with a built-in acceleration sensor of the present invention;

FIG11 is an ADC module of a dynamic blood glucose monitoring circuit with a built-in acceleration sensor of the present invention;

FIG12 is an acceleration sensor module of a dynamic blood glucose monitoring circuit with a built-in acceleration sensor of the present invention;

FIG13 is a motor wake-up alarm module of a dynamic blood glucose monitoring circuit with a built-in acceleration sensor of the present invention;

FIG. 14 is a wireless SoC module of a dynamic blood glucose monitoring circuit with a built-in acceleration sensor according to the present invention.

In the figure, 100-blood glucose transmitter, 110-blood glucose sensor component, 120-transmitter component, 111-switch element, 112-blood glucose sensor, 113-connecting part, 121-sensor excitation module, 122-sampling and conditioning module, 123-battery charging module, 124-lithium battery, 125-power management module, 126-flash memory module, 127-motor wake-up alarm module, 128-ADC module, 129-wireless SoC module, 130-acceleration sensor module, 200-mobile phone APP terminal, 210-user registration and login module, 220-blood glucose data monitoring module, 230-event input module, 240-data storage module, 250-blood glucose data sharing module, 260-blood glucose data statistical analysis module, 270-nursing and rescue service module, 300-cloud storage, 400-remote APP terminal.

Detailed ways

In order to better understand the above technical solution of the present invention, it is further described in detail below with reference to the accompanying drawings and embodiments.

An embodiment of the dynamic blood glucose monitoring circuit with built-in acceleration sensor of the present invention is shown in FIG1 , and the dynamic blood glucose monitoring circuit is composed of a blood glucose sensor component 110 with a built-in blood glucose sensor 112 and a transmitter component 120 connected. The blood glucose sensor component 110 and the transmitter component 130 adopt a detachable structure, and all circuit components of the transmitter component 120 are sealed and packaged with biocompatible materials, and the contacts V+, V-, S+, S- of the connection part 113 are left on the outside of the sealed package for connecting the blood glucose sensor component 110; the blood glucose sensor component 110 is connected to the transmitter component 120 through the contacts V'+, V'-, S'+, S'- corresponding to the connection part 113, forming the wearable blood glucose transmitter 100 of the dynamic blood glucose monitor directly monitored by the mobile phone APP of the present invention. The present invention can greatly save customer costs by separating the blood glucose sensor component 110 as a disposable consumable from the transmitter component 120 as a reusable component. V+, V-, S+, S- in Figure 1 are contacts of the connecting part 113 on one side of the transmitter component 120, and V’+, V’-, S’+, S’- are electrical contacts corresponding to the connecting part 113 and the blood glucose sensor component 110.

According to the embodiment shown in Figure 1, the transmitter component 120 includes a sensor excitation module 121, a sampling and conditioning module 122, an ADC module 128, a wireless SoC module 129, and a flash memory module 126; the transmitter component 120 also includes an acceleration sensor module 130 and a motor wake-up alarm module 127.

The transmitter assembly 120 further includes a battery charging module 123, a lithium battery 124 and a power management module 125; a switch element 111 is connected between the connection contacts V'+ and V'- of the blood glucose sensor assembly 110; when the connection 113 between the transmitter assembly 120 and the blood glucose sensor assembly 110 is disconnected, the electrical contacts V+ and V- of the connection 113 constitute the charging input terminal of the transmitter assembly 120, which can be connected to a 5V charging voltage, and the lithium battery 124 is charged through the battery charging module 123 of the transmitter assembly 120;

When the lithium battery 124 of the transmitter component 120 is fully charged, the 5V charging voltage is removed. Since the transmitter component 120 is not connected to the blood glucose sensor component 110, the lithium battery 124 and the power management module 125 are disconnected internally, and each circuit module connected to the power supply output end of the power management module 125 is in a power-off state. This connection method of the transmitter component 120 can realize automatic power-off of the transmitter component 120, thereby extending the standby time of the transmitter component 120 and extending the inventory shelf life of the blood glucose transmitter 100 product;

When blood glucose monitoring is required, the blood glucose sensor component 110 of the blood glucose transmitter 100 is implanted into the human body, the blood glucose sensor component 110 is connected to the transmitter component 120 via the connecting portion 113, the lithium battery 124 is connected to the power management module 125 via the switching element 111 inside the blood glucose sensor component 110, and each circuit module of the transmitter component 120 is powered on and starts working.

According to an embodiment of the blood glucose sensor assembly 110 of the present invention, the switch element 111 is a PCB short circuit line connected between the contacts V’+ and V’- of the connecting portion 113.

According to another embodiment of the blood glucose sensor assembly 110 of the present invention, the switch element 111 is a contact switch connected between the contacts V'+ and V'- of the connection part 113, and the switch element 111 works in a negative logic mode: when the switch element 111 is disconnected, the blood glucose transmitter 100 is powered on and works; when the switch element is closed, the blood glucose transmitter 100 loses power and stops working, and the transmitter assembly 110 remains in a power-off state; by closing and re-opening the switch element 111, the power-on reset operation of the wireless SoC module 129 can be achieved. In this embodiment, the transmitter assembly 120 is equipped with a contact protection cover with a short circuit line built in. When the contact protection cover closes the connection part 113 of the transmitter assembly 120, the short circuit line shorts the contacts V+ and V-, so that the transmitter assembly 120 remains in a power-off state, thereby extending the standby time of the transmitter assembly 120 and extending the inventory shelf life of the blood glucose transmitter 100 product.

The wireless SoC module 129 sends instructions to the sensor excitation module 121 to apply a suitable voltage to the sensor, and the blood glucose sensor 112 in the blood glucose sensor assembly 110 starts to work. The blood glucose sensor 112 generates a weak current signal, which reflects the blood glucose level of the human body.

The current signal generated by the blood glucose sensor 112 is converted into a voltage signal by the sampling and conditioning module 122, filtered, and sent to the ADC module 128 for circuit analog-to-digital conversion, and then converted into a digital signal and transmitted to the main control circuit wireless SoC module 129. The human blood glucose concentration value is calculated through calculation and stored in the flash memory module 126, or sent to the mobile phone APP terminal 200 in real time through a wireless connection.

An embodiment of the battery charging module 123 is shown in FIG8 , wherein a rechargeable lithium battery 124 is provided between J1 and J2. U1 is a charging management chip, preferably BQ24041, and the resistance value of resistor R18 is selected to set the rated current of the battery charging. The resistance value of resistor R21 is selected to set the battery charging cut-off current, and R22 is selected to set the maximum current limit of the charging. R23 is a pull-down resistor to enable the charging chip. The /SHDN signal is used to turn on and off the power management circuit. The specific logic is that when V+ and V- are short-circuited, /SHDN is pulled down to a low level through R4 and D1 to turn off the system power supply; when the charging power supply is connected to V+, V- or is suspended, the /SHDN output is pulled up to a high voltage through R1 and R4, and the signal is sent to the power management circuit to turn on the system power supply. When charging, the CHG_PG output signal is high and the CHG output signal is low. When charging is completed, CHG outputs a high level; when CHG_PG is high, it means that the charging power supply is not connected. The working status and charging status of the transmitter can be determined through the CHG_PG signal and the CHG signal status. These status are sent to the SOC operation, and then the breathing light connected to the SOC turns on, off, and flashes to indicate the corresponding status.

An embodiment of the power management module 125 is shown in FIG9 : the rated output voltage of the lithium battery 124 is about 3.7V, but the power supply of the wireless SOC and the power supply of the operational amplifier are 3V, and the reference voltage of the sensor excitation voltage is 1.25V. Therefore, the function of the power management module 125 is to reduce the output voltage of the 3.7V lithium battery to 3V through the power chip U2 (preferably UM1560DB), and use the precision reference power chip U3 (preferably REF3312) to generate a precise 1.25V reference voltage for the sensor excitation circuit. Since the circuit has an analog part and a digital part. In order to improve the sampling accuracy and anti-interference performance, the PCB of the power management module 125 adopts the measures of analog ground/power supply and digital ground/power supply isolation, and uses inductors L1, L2, and L3 to connect the isolated digital part and the analog part, and C2, C3, C4, and C5 are power supply filter capacitors.

According to the embodiment shown in FIG10 , the blood glucose acquisition circuit of the dynamic blood glucose monitoring circuit with a built-in acceleration sensor of the present invention includes a sensor excitation module 121 and a sampling and conditioning module 122: The blood glucose sensor 112 works based on the electrochemical principle. When working normally, it is necessary to apply voltage excitations of different gears to the sensor positive electrode S+, wherein Q2, R10, and R12 form a voltage gear selection circuit. The gate V_SEL of Q2 is connected to the IO pin of the SoC chip, and the voltage gear is selected by the single chip microcomputer. When Q2 is turned on, R10 does not participate in the operation of the operational amplifier circuit, and generates a voltage V1 to the sensor positive electrode S+. When Q2 is not turned on, R10 will participate in the operation of the operational amplifier circuit, and S+ will generate a voltage V2 to the sensor positive electrode S+. If more levels of voltage are needed, a voltage gear selection circuit can be added. : The signal output by the blood glucose sensor 112 is a current signal, which needs to be processed by the sampling and conditioning module 122 to generate an input voltage signal directly used for the ADC module 128. Since the current level of the blood glucose sensor 112 is very weak, at the nA level, a current/voltage op amp circuit is used to condition the signal. In the figure, R5 is a feedback resistor, and C7 is a feedback capacitor. C7 is used to offset the influence of the input capacitor and improve the response time. It also provides a certain time constant together with R5. U4 should use a precision op amp with low bias current. U4 is preferably TSV712, of which R5 is preferably a 1M~2M ohm precision resistor. Considering that the bandwidth required for the sensor signal is not high, C7 is preferably 10nF~100nF. After the current signal is converted into a voltage signal by the conditioning circuit, the output ADC_GLU is connected to the ADC circuit for analog-to-digital conversion. According to the virtual short principle of the op amp, Pin5 of the op amp is connected to a 1.25V voltage, which is equivalent to the sensor negative electrode S- being connected to the reference potential 1.25V.

An embodiment of the ADC module 128 is shown in Figure 11: In order to improve the AD sampling accuracy, this embodiment uses a dedicated differential input high-resolution ADC conversion chip, preferably ADS1220, and the output ADC_GLU of the sampling conditioning circuit and the reference voltage 1.25V of the sensor cathode S- are used as two differential inputs of the ADC. This method can effectively reduce the sampling noise and improve the reliability of the sampling results. The results of ADS1220 are output to the SOC main control circuit via SPI for calculation. R14, R16, C22, C27, and C28 form a signal filtering circuit that can effectively filter out the common-mode and differential-mode noise of the sampling signal. C20 and C21 are power supply filter capacitors. According to another embodiment of the present invention, the ADC module 128 uses the built-in ADC function module of the wireless SoC module 129.

The acceleration sensor module 130 is connected to the wireless SoC module 129. The wireless SoC module 129 detects the three-dimensional acceleration signal through the acceleration sensor module 130, collects the spatial acceleration data of the wearer of the blood glucose transmitter 100, extracts the posture measurement characteristics and motion statistical characteristics through data processing, and obtains the movement and sleep information of the human body; through the fall judgment based on the posture measurement characteristics, in the case of the human body falling forward and backward, sideways, and standing up quickly after falling, a fall alarm distress signal can be issued in time, and the relevant information can be recorded in the flash memory module 126, or sent to the mobile phone APP terminal 200 in real time. Considering the influence of noise and the high requirements of the fall detection algorithm for the detection accuracy, the Kalman filter algorithm can also be used to improve the accuracy of the algorithm.

An embodiment of the acceleration sensor module 130 is shown in FIG12 : In this example, a three-axis acceleration sensor U7 is used as an acceleration detection element, and the preferred model is LSH3DH. The three-axis acceleration sensor can measure the spatial acceleration of an object by detecting a three-dimensional acceleration signal when the direction of movement of the object is not known in advance, thereby comprehensively and accurately reflecting the motion properties of the object. For example, by processing the collected spatial acceleration data, posture measurement features and motion statistical features, including standard deviation, threshold, skewness, kurtosis, etc., are extracted to calculate and identify the wearer's standing, sitting, lying postures and walking, running, and jumping movements, and obtain human body movement and sleep information. The data communication interface of the acceleration sensor and the wireless SOC circuit supports SPI or I2C interface. The SPI interface is selected in this embodiment because the rate of SPI is much higher than I2C. C29 and C30 are power supply filter capacitors.

According to the embodiment of the dynamic blood glucose monitoring circuit with a built-in acceleration sensor of the present invention shown in Figure 1, the transmitter component 120 also includes a motor wake-up alarm module 127; the motor wake-up alarm module 127 is connected to the wireless SoC module 129. When it is found that the wearer is at risk of hypoglycemia coma, the dynamic blood glucose monitoring circuit starts awakening self-rescue through the motor wake-up alarm module 127, and sends a hypoglycemia coma distress signal through an external receiving terminal.

An embodiment of the motor wake-up alarm module 127 is shown in FIG13 : The pull-down resistor R26 at the input end of the MOS tube is used to ensure that the motor remains stationary at the moment of restarting, because the pin is at a high level after the chip is powered on, and the MOS is in a conducting state, so that the motor has a short vibration. M+, M- are connected to the eccentric vibration motor. The pin Motor is connected to the corresponding pin of the wireless SoC module 129. D3 is a freewheeling diode when the motor Q3 is disconnected.

It is very dangerous for diabetic patients to have hypoglycemia at night. Especially after the patient falls asleep, the hypoglycemic coma caused by hypoglycemia cannot be discovered in time, and the patient is unable to save himself or ask for help from others, which may delay the rescue time and even endanger his life. Existing blood glucose meters with alarm function usually place the alarm circuit in the wireless receiver, but because the connection between the wireless receiver and the blood glucose transmitter may be disconnected, at this time, even if the blood glucose transmitter detects a dangerous blood glucose signal, the blood glucose data cannot be sent to the wireless receiver in time because of the disconnection; the wireless receiver cannot know that the patient is currently in a dangerous blood glucose state, and therefore cannot issue an alarm. The dynamic blood glucose monitoring circuit with a built-in acceleration sensor of the present invention places the motor wake-up alarm module 127 in the transmitter component 120 of the blood glucose transmitter 100 and is directly worn on the human body; when a dangerous blood glucose signal is detected, even if it is separated from the wireless receiver, the blood glucose transmitter 100 can still directly issue an alarm that can be perceived by the human body through the motor wake-up alarm module 127.

The technical solution of the present invention adopts a progressive awakening method according to the sleep state, which can greatly improve the user experience and avoid patients from having bad emotions due to the existing alarm function often directly waking them up from sleep, which in turn will turn off the nighttime hypoglycemia alarm function and cause potential risks.

According to the embodiment shown in FIG. 14 , the wireless SoC module 129 integrates a microprocessor cotex-M0 and a Bluetooth low energy module (Bluetooth BLE module). Y2, C12, and C14 form a low-frequency clock source, and Y1, C10, and C11 form a high-frequency clock source. Pin19 to Pin23 are data communication interfaces between the SOC and the ADC circuit, and Pin8 to Pin11, Pin25, and Pin26 are data communication interfaces between the SOC and the acceleration sensor module 130. Pin4 is used for voltage gear selection of the sensor excitation module 121. R17 and D2 are connected in series on Pin5 as a breathing light of the entire system to indicate the simple status of the blood glucose transmitter 100. Pin6 and Pin7 are for battery status detection, which can detect whether the battery is charging, fully charged, or not connected to the charging power supply. TP1 to TP4 are program burning and simulation input ports. L4, L5, L6, C17, C18, C19, and C26 are balun circuits, which also play a role in antenna impedance matching. E1 is the antenna. R13 and R15 are connected to the AD pin Pin48 of SOC through voltage division for battery power detection.

Although the wireless transceiver unit built into the wireless SoC module in this embodiment is preferably a Bluetooth BLE module, in fact, the wireless transceiver unit can also use zigbee, wifi, or ISM433/868/915Mhz frequency band communication based on unlicensed use; near-field communication methods similar to NFC/RFID can also be used.

The technical solution of the present invention can also use the acceleration sensor module 130 to provide a step counting function and a derived energy consumption function, and apply it to blood sugar control. For example, statistics are taken for a period of time, and the relationship between the patient's step count and energy consumption and the amount of blood sugar change during this period is counted, and the law of the patient's own step count and blood sugar change is excavated. If the current blood sugar is high, the patient knows how many steps are needed to reduce the blood sugar to a safe range.

FIG2 is an embodiment of a dynamic blood glucose monitor directly monitored by a mobile phone APP of the present invention, comprising a blood glucose transmitter 100, at least one mobile phone APP terminal 200 as a dynamic blood glucose monitoring external terminal, and a cloud storage 300 connected via the mobile phone APP terminal 200;

The blood glucose transmitter 100 adopts the above-mentioned dynamic blood glucose monitoring circuit, including a blood glucose sensor 112, a sensor excitation module 121, a sampling and conditioning module 122, an ADC module 128, a wireless SoC module 129, an acceleration sensor module 130 and a motor wake-up alarm module 127; the sensor excitation module 121 applies an excitation voltage to the blood glucose sensor 112; the sampling and conditioning module 122 conditions the current signal of the blood glucose sensor 112 into a voltage signal matching the ADC module 128; the ADC module 128 converts the conditioned voltage signal into a digital signal and sends it to the main control chip of the transmitter wireless SoC module 129, and the main control chip calculates the blood glucose concentration according to the sampled and converted digital signal, and sends it to the mobile phone APP terminal 200 through the Bluetooth BLE module integrated in the wireless SoC module 129; the acceleration sensor module 130 is connected to the wireless SoC module 129 to obtain the movement and sleep information of the human body, so as to realize the recognition of hypoglycemia coma and the awakening self-rescue and alarm rescue functions;

The mobile phone APP terminal 200 is connected to the blood glucose transmitter 100 via Bluetooth mode to achieve dynamic monitoring of blood glucose concentration; the mobile phone APP terminal 200 is connected to the cloud storage 300 via a mobile communication network;

The cloud storage 300 is used to store the blood glucose data collected by the blood glucose transmitter, and to realize network sharing of the blood glucose monitoring data by pushing it to authorized users.

According to the embodiment of the dynamic blood glucose monitor directly monitored by the mobile phone APP of the present invention shown in FIG2, it also includes at least one remote APP terminal 400 as a dynamic blood glucose monitoring external terminal; the remote APP terminal 400 includes at least a blood glucose data monitoring module, a blood glucose data statistical analysis module and a nursing assistance alarm module; when the mobile phone APP terminal 200 authorizes the remote APP terminal 400, the remote APP terminal 400 receives the data uploaded by the blood glucose transmitter 100 through the mobile phone APP terminal 200, and realizes the remote monitoring and statistical analysis of the blood glucose transmitter; the nursing assistance alarm module receives the nursing assistance alarm information issued by the mobile phone APP terminal 200, and realizes the remote nursing assistance alarm service of hypoglycemia coma. The remote APP terminal 400 includes a mobile phone, tablet computer or desktop computer of the wearer's family members or medical staff.

According to an implementation of the mobile phone APP directly monitored dynamic blood glucose monitor of the present invention, as shown in FIG3 , the mobile phone APP terminal 200 includes the following functional modules: user registration and login module 210 , blood glucose data monitoring module 220 , event input module 230 , data storage module 240 , blood glucose data sharing module 250 , blood glucose data statistical analysis module 260 , nursing assistance service module 270 ;

The user registration and login module 210 is used for the management of the user account of the system and the user data authorization agreement; the blood glucose data monitoring module 220 is used to control the action of the blood glucose transmitter 100, and receive the blood glucose concentration data sent by the blood glucose transmitter 100, and display the blood glucose concentration data in real time;

The event input module 230 supports text input and voice recognition input, and can record the patient's life events in multiple dimensions to provide diagnosis and treatment information for doctors. The life events include exercise, medication, diet and daily life information;

The data storage module 240 records the blood sugar monitoring history data and the life events, so as to understand the life habits that are beneficial to the blood sugar level;

The blood glucose data sharing module 250 pushes the blood glucose data to family members or medical staff in real time through the cloud storage 300, thereby realizing remote monitoring of the wearer's dynamic blood glucose;

The blood sugar data statistical analysis module 260 is used to collect statistics of historical blood sugar data and obtain the statistical law of blood sugar changes during blood sugar monitoring;

The nursing assistance service module 270 is used to receive the fall alarm distress signal and the low sugar coma distress signal sent by the blood glucose transmitter 100, and send the nursing alarm distress information to the remote APP terminal 400.

FIG4 is a flow chart of a control method for the above-mentioned dynamic blood glucose monitoring circuit with a built-in acceleration sensor, comprising the following steps;

S100: Collection and preprocessing of dynamic blood glucose concentration detection data;

S200: Collection of human posture data and behavioral action recognition;

S300: Identification and awakening of hypoglycemia coma, self-rescue and alarm for help;

S400: Wireless transmission of blood glucose monitoring data.

According to the dynamic blood glucose concentration detection data collection and processing flow chart shown in FIG5 , the step S100 includes the following actions:

S110: blood glucose transmitter is powered on and initialized;

S120: The built-in Bluetooth BLE module of the blood glucose transmitter establishes a data communication connection with the mobile phone APP terminal via Bluetooth BLE;

S130: Start the blood glucose sensor, write the current time to the blood glucose transmitter, and synchronize the blood glucose sampling cycle;

S140: The blood glucose transmitter applies a predetermined voltage to stimulate the blood glucose sensor;

S150: The blood glucose sensor enters the polarization waiting time; after the polarization is completed, the mobile phone APP terminal 200 writes the reference blood glucose into the blood glucose sensor;

S160: The blood glucose transmitter starts to collect the current signal in the blood glucose sensor, and after being conditioned by the sampling and conditioning module, the current signal is sampled and converted into a digital signal by the ADC module and transmitted to the wireless SoC module, and then calculated and converted into a blood glucose value representing the blood glucose concentration;

S170: The built-in Bluetooth BLE module sends the blood sugar value to the mobile phone APP terminal via Bluetooth.

According to the embodiment of the control method of the dynamic blood glucose monitoring circuit shown in FIG6 , the step S200 includes the following actions:

S210: The blood glucose transmitter reads the three-axis acceleration detection data through the acceleration sensor;

S220: Perform posture analysis and human motion recognition based on the three-axis acceleration detection data, and send the wearer's posture or motion status to the mobile phone APP terminal;

S230: If the recognition result is a walking or running state, collect and send the wearer's motion data to the mobile phone APP terminal, and the motion data at least includes the number of walking or running steps;

S240: If the identification result is a fall event of the wearer, a fall alarm distress signal is sent to a remote APP terminal via the mobile phone APP terminal;

The step S300 includes the following actions:

S310: If the recognition result is coma or sleep state, go to step S320; otherwise, return to step S210;

S320: If the blood sugar monitoring result is hypoglycemia, it is determined that the wearer is at risk of hypoglycemia coma, and the process goes to step S330; otherwise, the process goes back to step S210;

S330: starting the wake-up self-rescue service through the motor wake-up alarm module built into the blood glucose transmitter;

S340: If awakening and self-rescue is effective, return to step S210; otherwise, send a low-sugar coma distress signal to a remote APP terminal via the mobile phone APP terminal.

According to the embodiment shown in FIG7 , the wireless transmission of blood glucose monitoring data adopts Bluetooth mode. Due to the attenuation and loss of Bluetooth signal or software requirements, during the normal blood glucose collection process, the built-in Bluetooth transmission module of the blood glucose transmitter 100 and the mobile phone APP terminal 200 may be in a connected state or a disconnected state. Therefore, the blood glucose monitoring data is sent to the mobile phone APP terminal 200 in two ways. The step S400 includes the following actions:

S410: The blood glucose transmitter determines the connection status. If the Bluetooth connection is in the connection status, go to step S420. Otherwise, return to wait for the blood glucose transmitter 100 and the mobile phone APP terminal 200 to re-establish the connection. Since the blood glucose signal cannot be sent to the mobile phone APP terminal 200 in real time at this time, the collected blood glucose value is usually temporarily stored in the flash memory module 126 of the SOC.

S420: The mobile APP terminal first queries and reads historical data from the flash memory module 126;

S430: If all historical data have been sent, the real-time sending state is entered, and the blood glucose transmitter 100 sends the latest collected blood glucose monitoring data to the mobile phone APP terminal.

After the mobile phone APP terminal 200 receives the blood glucose concentration value from the transmitter, it is displayed in real time on the mobile phone, and the data is sent to the cloud storage 300. When a certain number of blood glucose concentration values are sampled, the APP user can choose to display all historical monitoring values in the form of a continuous graph.

When a user has a life event, the user can directly enter the life event into the mobile phone APP terminal 200 by text input or voice. The life events include life events related to diet, exercise, medication and blood sugar level. The mobile phone APP terminal 200 can display the blood sugar graph 3 to 5 hours before and after the event based on the time point of event entry, which is used to determine the impact of life events on blood sugar concentration. And the continuous blood sugar graphs corresponding to each life event can be superimposed for comparative observation.

After the monitoring is completed, the mobile phone APP terminal 200 sends a command to end the monitoring to the blood glucose transmitter 100, and the blood glucose transmitter 100 stops working. The user can remove the blood glucose transmitter 100 from the human body, or disconnect the connection part 113 between the transmitter component 120 and the blood glucose sensor component 110, and remove the transmitter component 120 from the human body to end the entire blood glucose monitoring process.

Those skilled in the art should recognize that the above embodiments are only used to illustrate the technical solutions of the present invention, and are not intended to limit the present invention. Any changes or modifications made to the above embodiments based on the essential spirit of the present invention shall fall within the scope of protection of the claims of the present invention.

Claims (1)

1. A dynamic blood sugar monitoring circuit with an internal acceleration sensor is formed by connecting a blood sugar sensor component with an internal blood sugar sensor with a transmitter component; the transmitter assembly comprises a sensor excitation module, a sampling conditioning module, an ADC module, a wireless SoC module and a flash memory module, wherein the sensor excitation module is connected to a blood glucose sensor to provide voltage excitation for the blood glucose sensor, a current signal output by the blood glucose sensor is converted into a voltage signal through the sampling conditioning module, the voltage signal is converted into a digital signal through the ADC module and is transmitted to the wireless SoC module, and a blood glucose concentration value is calculated through calculation and stored in the flash memory module or is transmitted to an external receiving terminal through wireless connection, and the transmitter assembly is characterized in that:

The blood glucose sensor component and the emitter component adopt a separable structure, and the blood glucose sensor component which is used as a disposable consumable is separated from the emitter component which is used as a reusable component, so that the cost of a customer is saved;

All circuit components of the transmitter assembly are hermetically packaged by adopting a biocompatible material, and contacts V+, V-, S+, S-, of a connecting part are reserved outside the hermetically packaged components and are used for connecting a blood glucose sensor assembly; the blood glucose sensor component and the transmitter component are connected through a connecting part to form a wearable blood glucose transmitter for dynamic blood glucose monitoring;

The emitter assembly also comprises a battery charging module, a lithium battery and a power management module; a switch element is connected between the contacts V '+ and V' -of the blood glucose sensor component connecting part; when the connection part between the emitter component and the blood glucose sensor component is disconnected, the contacts V+ and V-of the connection part form a charging input end of the emitter component, and charging voltage can be accessed to charge the lithium battery through the battery charging module; when the charging of the transmitter assembly is finished and the charging voltage is removed and the blood glucose sensor assembly is not connected, the lithium battery of the transmitter assembly is disconnected from the inside of the power management module, and all circuit modules connected to the power supply output end of the power management module are in a power-off state; when blood sugar monitoring is needed, the built-in blood sugar sensor of the blood sugar sensor assembly is connected to the transmitter assembly through contacts S+ and S-of the connecting part, the lithium battery is connected to the power management module through a switching element in the blood sugar sensor assembly, and all circuit modules of the transmitter assembly are electrified to start working;

the switch element is a PCB shorting line connected between contacts V '+ and V' -of the connection portion;

Or the switching element is a contact switch connected between contacts V '+ and V' -of the connection portion, the switching element operating in a negative logic mode: when the switch element is turned off, the blood sugar transmitter is powered on to work; when the switch element is closed, the blood sugar transmitter is powered off to stop working, and the transmitter is kept in a power-off state; and the power-on reset operation of the wireless SoC module is realized through the closing and reopening of the switching element.