CN108070011A - A kind of galactolipin sugar ester base compound donator and preparation method thereof - Google Patents
A kind of galactolipin sugar ester base compound donator and preparation method thereof Download PDFInfo
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Abstract
A kind of galactolipin sugar ester base compound donator and preparation method thereof, compound name are 12,3,4 three O benzyls of thio-phenyl, 6 O substituted acyls, 1 deoxidationβD gala sugar esters, general structure are：, wherein R is the carbochain or aromatic rings that carbon number is 1-14：The present invention provides can build 6 substitution galactolipin end group sulphur glycosides to provide the galactolipin sugar ester donor that 6 acyl groups substitute 1 sulphur glycosides activation; it, so as to further build complicated oligosaccharides ester, lays the foundation available for using general " sulphur glycosides method " generation glycosidic bond for the research of complex oligosaccharide ester.
Description
Technical field
The present invention relates to a kind of midbody compound, specifically a kind of galactolipin sugar ester base compound donator and its system
Preparation Method.
Background technology
Oligosaccharides and oligosaccharides ester are a kind of important structure types in natural products.Oligosaccharides and oligosaccharides ester type compound not only have
There are the bioactivity such as antitumor, anti-inflammatory, anti-oxidant and strengthen immunity, and there is polyhydroxy structure, structure sheet in its molecule
Body determines that the drug molecule compared with other structures type has higher water solubility and oral administration biaavailability, while carbohydrate molecule sheet
Body toxic side effect very little, therefore, such bioactive molecule have stronger patent medicine begetting power, cause pharmaceutical chemistry and study on the synthesis
The extensive concern of personnel.
The structure of glycosidic bond is the important content in oligosaccharides and its research of oligosaccharides Lipase absobed, and sugared end group is replaced to sulphur glycosides to carry
The important method in oligosaccharides and oligosaccharides Lipase absobed is become for glycosyl donor.However, structure 6 substitution galactolipin end group sulphur glycosides with
There is provided galactolipin sugar ester donor that 6 acyl groups substitute 1 sulphur glycosides activation and preparation method thereof, there is no literature reported on serious restriction is logical
Cross the research of the further composite structure complex oligosaccharide ester of such glycosyl donor.
The content of the invention
The technical problems to be solved by the invention be to provide it is a kind of can be used for further build complicated oligosaccharides ester
Galactolipin sugar ester base compound donator and preparation method thereof.
The present invention to solve above-mentioned technical problem the technical solution adopted is that：A kind of galactolipin sugar ester base donor chemical combination is provided
Object, compound name be 1- thio-phenyls -2,3, tri--O- benzyl -6-O- substituted acyl -1- deoxidations of 4- -β- D- gala sugar esters,
General structure is：
Wherein, R is the structures such as carbochain, substituted benzene ring or the other aromatic rings that carbon number is 1-14.
The preparation method of the galactolipin sugar ester base compound donator, includes the following steps：
Step 1: using galactolipin as raw material, total oxygen acetylation galactolipin is generated under the action of acetylation reagent and alkali；
Step 2: total oxygen acetylation galactolipin is mixed with benzenethiol, catalysts and solvents, compound IV is made in glycosidation,
Its structural formula is：
Step 3: compound IV is mixed with alkali and solvent, deacetylation generation compound V, structural formula is：
Step 4: compound V is mixed with triphenylchloromethane and alkali, reaction generation compound VI, structural formula is：
Step 5: compound VI is mixed with bromobenzyl, alkali and solvent, reaction generation compound VII, structural formula is：
Step 6: compound VII is mixed with acid and solvent, reaction sloughs trityl and obtains compound VIII, structural formula
For：
Step 7: by compound VIII and substituted carboxylic acid, condensing agent, alkali and solvent, reaction sloughs trityl and obtains described half
Lactose sugar ester base compound donator.
In the step 1, by galactolipin, acetylation reagent and alkali according to 1:(5—25)：The molar ratio of (5-25) is mixed
Close, under 0-140 DEG C of reaction temperature react 0.5-8 it is small when, the acetylation reagent be acetic anhydride or chloracetyl, it is described
Alkali be pyridine, triethylamine or sodium acetate.
In the step 2, by total oxygen acetylation galactolipin and benzenethiol, catalysts and solvents according to 1:(1—5) ：
(1—25)：The mixed in molar ratio of (5-50), when reaction 0.5-24 is small under 0-140 DEG C of reaction temperature, the catalysis
Agent is Fe/I2Or FeI2, solvent is dichloromethane, tetrahydrofuran or acetone.
In the step 3, by compound IV, alkali and solvent according to 1:(4—40)：The mixed in molar ratio of (5-50),
When reaction 0.5-8 is small under 0-50 DEG C of reaction temperature, the alkali is K2CO3, NaOH or NaOCH3, solvent is methanol or water.
In the step 4, by compound V, triphenylchloromethane and alkali according to 1:(1—5)：The molar ratio of (1-25) is mixed
It closes, when reaction 0.5-24 is small under 0-120 DEG C of reaction temperature, the alkali is pyridine or triethylamine.
In the step 5, by compound VI, bromobenzyl, alkali and solvent according to 1:(4—15)：(4—15)：(5-50)
Mixed in molar ratio, when reaction 0.5-24 is small under 0-100 DEG C of reaction temperature, the alkali is NaH or CaH2, solvent N,
Dinethylformamide, tetrahydrofuran or acetone.
In the step 6, by compound VII, acid and solvent according to 1:(1—10)：The mixed in molar ratio of (5-50),
When reaction 0.5-8 is small under 0-50 DEG C of reaction temperature, the acid is HCl or p-methyl benzenesulfonic acid, solvent for dichloromethane or
Methanol.
In the step 7, by compound VIII, substituted carboxylic acid, condensing agent, alkali and solvent according to 1:(1—3)：(1—
3)：(2—6)：The mixed in molar ratio of (5-25), when reaction 0.5-24 is small under 0-50 DEG C of reaction temperature, the condensation
Agent is EDCI/HOBt, BOP, PyBOP, DCC or CDI, and alkali is pyridine, triethylamine or DIEA, and solvent is dichloromethane, tetrahydrochysene furan
It mutters or acetone.
The beneficial effects of the invention are as follows：The implementation of the present invention will build 6 substitution galactolipin end group sulphur glycosides to provide 6
Position acyl group substitutes the galactolipin sugar ester donor of 1 sulphur glycosides activation, available for using general " sulphur glycosides method " generation glycosidic bond so as into
One step builds complicated oligosaccharides ester, for example, the compound that formula of of the present invention is I can be in the catalysis of triflate
Further reaction into glycosides and then synthesizes complex oligosaccharide ester to lower and other carbohydrate hydroxyls.Using above method first by galactolipin total oxygen second
It is acylated, with benzenethiol reaction into deacetylation again after glycosides, then upper trityl generation compound VI, by benzyl protection with it is de-
Two step of trityl generates key intermediate compound VIII, and the galactolipin sugar ester of the present invention is finally condensed to yield with substituted carboxylic acid
Base compound donator, it is ensured that according to reaction scheme smoothly, efficiently generate target compound, established for the research of complex oligosaccharide ester
Basis.
Description of the drawings
Fig. 1 is the reaction scheme schematic diagram of preparation method of the present invention.
Fig. 2 is 1 formula III compound of embodiment1H NMR spectras.
Fig. 3 is 1 formula IV compound of embodiment1H NMR spectras.
Fig. 4 is 1 Formula V compound of embodiment1H NMR spectras.
Fig. 5 is 1 Formula IV compound of embodiment1H NMR spectras.
Fig. 6 is the mass spectrogram of 1 Formula IV compound of embodiment.
Fig. 7 is 1 Formula VII compound of embodiment1H NMR spectras.
Fig. 8 is the mass spectrogram of 1 Formula VII compound of embodiment.
Fig. 9 is 1 Formula VIII compound of embodiment1H NMR spectras.
Figure 10 is the mass spectrogram of 1 Formula VIII compound of embodiment.
Figure 11 is 1 target compound of embodiment1H NMR spectras.
Figure 12 is 1 target compound of embodiment13C NMR spectras.
Specific embodiment
The galactolipin sugar ester base compound donator of the present invention, chemical name are named as：1- thio-phenyls -2,3,4- three -
O- benzyl -6-O- substituted acyl -1- deoxidations -β- D- gala sugar esters, general structure are：
Wherein, R is the structures such as carbochain, substituted benzene ring or other aromatic rings that carbon number is 1-14, such as：
、、、、、、、、、、、、、、、、、、。
The galactolipin sugar ester base compound donator is with galactolipin（Compound II）For raw material, total oxygen acetylation gala is first made
Sugar（Compound III）, then reacted with benzenethiol and generate compound IV, compound V is obtained through deacetylation, then upper trityl
Generate compound VI, key intermediate compound VIII generated by benzyl protection and two step of detritylation, finally with substitution
Carboxylic acid is condensed to yield the galactolipin sugar ester base compound donator I of the present invention.The specific species of substituted carboxylic acid is according to compound formula
In R determine, select different substituted carboxylic acids that can obtain different R, so as to which different particular compounds be made.
Its reaction scheme is as shown in Figure 1.
Specific preparation method is as follows：
（1）, galactolipin（Formula II）Total oxygen acetylation galactolipin is generated under the action of acetylation reagent and alkali（Structural formula
III）；Wherein, the molar ratio of galactolipin, acetylation reagent and alkali is 1:(5—25)：(5—25)；Acetylation reagent is acetic acid
Acid anhydride, chloracetyl etc., alkali are pyridine, triethylamine and sodium acetate etc.；Reaction time is 0.5-8 h；Reaction temperature is 0-140
℃。
（2）, total oxygen acetylation galactolipin（Formula III）In benzenethiol, catalysts and solvents compound IV is obtained into glycosides；Its
In, total oxygen acetylation galactolipin, benzenethiol, the molar ratio of catalysts and solvents are 1:(1—5)：(1—25)：(5—50)；It urges
Agent is Fe/I2、FeI2It is dichloromethane, tetrahydrofuran, acetone etc. Deng, solvent；Reaction time is 0.5-24 h；Reaction temperature
For 0-140 DEG C.
（3）, compound IV deacetylation generation compound V in alkali and solvent；Wherein, compound IV, alkali and solvent
Molar ratio is 1:(4—40)：(5—50)；Alkali is K2CO3、NaOH、NaOCH3It is methanol, water etc. Deng, solvent；Reaction time is
0.5—8 h；Reaction temperature is 0-50 DEG C.
（4）, compound V triphenylchloromethane and alkali effect under on trityl obtain compound VI；Wherein, compound
V, the molar ratio of triphenylchloromethane and alkali is 1:(1—5)：(1—25)；Alkali is pyridine, triethylamine etc.；Reaction time is
0.5—24 h；Reaction temperature is 0-120 DEG C.
（5）, compound VI benzyl protection hydroxyls in bromobenzyl, alkali and solvent obtain compound VII；Wherein, compound VI,
The molar ratio of bromobenzyl, alkali and solvent is 1:(4—15)：(4—15)：(5—50)；Alkali is NaH, CaH2Deng solvent N, N- bis-
Methylformamide, tetrahydrofuran, acetone etc.；Reaction time is 0.5-24 h；Reaction temperature is 0-100 DEG C.
（6）, compound VII acid and solvent in detritylation obtain compound VIII；Wherein, compound VII, acid and
The molar ratio of solvent is 1:(1—10)：(5—50)；Acid is HCl, p-methyl benzenesulfonic acid etc., and solvent is dichloromethane, methanol etc.；Instead
It is 0.5-8 h between seasonable；Reaction temperature is 0-50 DEG C.
（7）, detritylation obtains compound I in compound VIII and substituted carboxylic acid, condensing agent, alkali and solvent.Wherein,
Compound VIII, substituted carboxylic acid, condensing agent, the molar ratio of alkali and solvent are 1:(1—3)：(1—3)：(2—6)：(5—25)；
For condensing agent for EDCI/HOBt, BOP, PyBOP, DCC, CDI etc., alkali is pyridine, triethylamine, DIEA etc., solvent is dichloromethane,
Tetrahydrofuran, acetone etc.；Reaction time is 0.5-24 h；Reaction temperature is 0-50 DEG C.
The specific process parameters such as reaction temperature, reaction time, raw material proportioning in above steps can influence each step life
Yield, raw material availability into compound etc., but select technological parameter that can have respective reaction in more than numberical range,
The compound can be made.Therefore, protection scope of the present invention is not limited to the optimal embodiment of following embodiment.
Embodiment 1
A, prepare compound III
Anhydrous acetic acid acid anhydride (57.66 mL, 609.98 mmol) and pyridine (50.00 mL) are added in into three-necked bottle, is then added in batches
Enter galactolipin (20.00 g, 111.01 mmol), after charging, heat up and be sufficiently stirred, when temperature rises to 80 DEG C, gala
Sugar starts to dissolve, and continues 80 DEG C and is stirred to react 4 h, TLC monitorings are completed until reaction.Mixture is become from white in reaction process
It is orange, it eventually becomes orange red.After cooling, pyridine is removed under reduced pressure.Water (300 mL) is added in, is vigorously stirred, white solid is precipitated,
It filters, the appropriate washing of filter cake press dry, and filter cake puts dry 26.20 g of white solid, i.e. compound III, yield under infrared lamp
93.18 %。m. p. 107-109 oC。 1H-NMR(400 MHz, CDCl3) δ(ppm): 5.71 (d, J= 8.32 Hz,
1H, HC(3)), 5.43 (d, J= 2.64 Hz, 1H, HC(1)), 5.34 (tri, J=8.64 Hz ,1H, HC
(2)), 5.09 (dd, J 1 = 10.36 Hz , J 2 =3.32 Hz, 1H, HC(5), 4.19~4.10 (m, 2H,
COOCH 2), 4.06 (tri, J= 6.68 Hz, 1H, HC(4)),2.00~2.17 (m, 15H, O=C-CH 3)。
B, prepare compound IV
Intermediate compound III (19.58 g, 50.21 mmol) is dissolved in dichloromethane (150 mL) in eggplant-shape bottle,
Add in FeI2 (98.00 mL) and benzenethiol (9.46 mL, 9.21mmol), after charging, is placed in magnetic stirring apparatus at room temperature
On be sufficiently stirred 1 h, TLC monitorings are completed until reaction.It adds in saturated sodium bicarbonate (100 mL) to be quenched, uses unsaturated carbonate respectively
Hydrogen sodium (50 mL × 3) and saturated sodium-chloride (50 mL × 3) extraction, after anhydrous sodium sulfate is fully dried, filter, remove under reduced pressure molten
Agent.Crude product is purified through column chromatography, obtains colourless viscous liquid 13.17g, is compound IV, 50.35 % of yield.1H-NMR
(400 MHz, CDCl3) δ (ppm): 7.47 (tri, J = 7.12 Hz, 2H, ArH), 7.39~7.29 (m, 3
H, ArH), 5.34~5.23 (m, 3 H, HC(3), HC(1), HC(2)), 5.13~5.03 (m, 1H, HC(5)),
4.32 (tri, J = 6.24 Hz, 1H, HC(4)), 4.11~4.02 (m, 2H, COOCH 2), 2.16~1.92 (m,
12H, O=C-CH 3)。
C, prepare compound V
Sodium (0.11 g, 4.56 mmol) is added in methanol aqueous solution (10.00 mL) at room temperature, is sufficiently stirred, sodium is molten rapidly
Simultaneously heat release is solved, after cooling, adds in compound IV (2.20 g, 5.00 mmol), stirring is allowed to fully dissolve, after reacting 5 min
TLC is monitored, and reaction is completed.Ethereal HCI solution is added in, adjusts pH to neutrality, solution colour becomes milky white from orange at this time.It takes out
Salt is filtered out, solvent is evaporated off in filtrate decompression, obtains 1.36 g of white solid, is compound V, 93.18 % of yield.m. p. 100-
104 oC。 1H-NMR (400 MHz, CDCl3) δ(ppm): 7. 43 (d, J =7.36 Hz, 2H, ArH), 7.33~
7.28 (m, 2H, ArH), 7.19 (tri, J =7.32 Hz, 1H, ArH), 4.58 (d, J =9.44 Hz, 1H,
HC(1)), 3.74 (d, J=2.92 Hz, 1H, HC(3)), 3.56~3.35 (m, 9H, OH*4, HC(2, 4, 5),
CH2)。
D, prepare compound VI
In three-necked bottle, compound V (1.00 g, 3.68 mmol) is completely dissolved in pyridine (20 mL), adds triphenyl
Chloromethanes (1.05 g, 3.70 mmol), temperature to 1.5 h are sufficiently stirred under the conditions of 85 DEG C, until reaction tie by TLC monitorings in control
Beam.It removes solvent under reduced pressure, obtains yellowish 2.60 g of thick liquid.Crude product is purified through column chromatography, removes solvent under reduced pressure, is obtained brownish red and is consolidated
1.00 g of body is compound VI, 26.42 % of yield.1H-NMR(400 MHz, CDCl3) δ (ppm): 7.54(d, J
= 7.36 Hz, 2H, ArH), 7.39 (d, J = 7.28 Hz, 6H, ArH), 7.32~7.16 (m, 12H, ArH),
5.22 (d, J = 5.76 Hz, 1H, HC(1)),4.96（d,J = 5.04 Hz, 1H, HC(2)), 4.73 (d, J
=9.32 Hz, 1H, OH), 4.53 (d, J = 4.36 Hz, 1H, OH), 3.75 (d, J = 5.36 Hz, 1H,
OH), 3.54 (tri , J = 3.44 Hz, 1H, HC(5)), 3.46~3.28 (m, 4H, HC(3), HC (4) ,
CH2). MS(ESI(-)70V, m/z): 514.6 [M-H]- 。
E, prepare compound VII
In three-necked bottle, compound VI (0.51 g, 0.99 mmol) is dissolved in DMF (3 mL), add in NaH (60 %,
0.17 g, 4.17 mmol), bromobenzyl (0.48 mL, 3.97 mmol) is added in after 30 min of stir thoroughly at room temperature, rise temperature is extremely
30 DEG C are continued to be stirred to react, TLC monitorings, until reaction is completed.30 mL water quenchings are added in go out, after adding in dichloromethane layering, upper strata
Water is mutually extracted with dichloromethane (15 mL × 3), merges organic phase, respectively with water (10 mL × 2) and saturated sodium-chloride (10 mL
× 2) wash, anhydrous magnesium sulfate drying filters, removes solvent under reduced pressure.Crude product is purified through column chromatography, obtains 0.40 g of yellow oil
, it is compound VII, 51.52 % of yield.1H-NMR(400 MHz, CDCl3) δ(ppm): 7.54(tri, J = 1.40
Hz, 2H, ArH), 7.40~7.20 (m, 31H, ArH), 7.00~7.02 (m, 2H, ArH), 4.95 (d, J =
9.64 Hz, 1H, HC(1)), 4.80~4.49 (m, 6H, 3*PhCH 2), 4.35 (d, J = 11.48 Hz, 1H,
HC(6)), 4.02 (d, J =2 .28 Hz, 1H, HC(3)), 3.93~3.90 (m, 1H, HC(2)), 3.80~3.78
(dd, J 1 = 9.28 Hz, J 2 = 2.62 Hz, 1H, HC(4)), 3.65 (tri, J = 9.48 Hz, 1H, CH2),
3.35~3.30 (m, 1H, CH2). MS(ESI(-)70V, m/z): 785.0 [M-H]-。
F, prepare compound VIII
Compound VII (0.20g, 0.26 mmol) is dissolved in dichloromethane or methanol (2mL), is added inp-TsOH.H2O
(20 mg), after 1 h of stir thoroughly at room temperature, TLC monitorings, until reaction terminates.It removes solvent under reduced pressure, adds in dichloromethane (30
ML) dissolve, extracted respectively with saturated sodium bicarbonate (20 mL × 2) and saturated sodium-chloride (20 mL × 2), collected all organic
Phase is dried with anhydrous sodium sulfate, is filtered, is removed dichloromethane under reduced pressure, obtain brown viscous liquid.Crude product is purified through column chromatography, is obtained
0.06 g of white solid is compound VIII, 43.14 % of yield.1H-NMR (400MHz, CDCl3) δ (ppm):
7.52~7.50 (dd, J 1 = 8.08 Hz, J 2 =1.76 Hz, 2H, ArH), 7.38~7.22 (m, 18H, ArH),
4.91 (tri, J = 5.48 Hz, 1H, HC(1)), 4.87~4.78 (m, 7H, PhCH2 *3, HC(5)), 4.13
(d, J = 2.32 Hz, 1H, HC(3)), 3.79~3.76 (dd, J 1 = 9.24 Hz, J 2 = 2.60 Hz, 1H,
CH2OH), 3.72~3.63 (m, 2H, CH2OH, HC(2)), 3.57 (tri, J = 10.92 Hz, 1H, HC(4)).
MS(ESI(-)70V, m/z): 542.7 [M-H]-。
G, target compound is prepared
Compound VIII (40.0 mg, 73.62 μm of ol) and dichloromethane (2 mL) are added in 10 mL eggplant type bottles, is stirred,
Fully n-nonanoic acid (26 μ L, 0.1472 mmol), PyBop (78 mg, 0.1472 mmol) and triethylamine are sequentially added after dissolving
(21 μ L, 0.1472 mmol), 33 DEG C are stirred to react 4 h, and TLC is monitored to reaction and completed, and mixture color is still water white transparency
Shape.Start to post-process after cooling, after reaction solution is added in dichloromethane (35 mL) dilution, respectively with the dilute hydrochloric acid of 0.2 mol/L
Solution (10 mL × 3), saturated sodium bicarbonate (10 mL × 3) and saturated sodium-chloride (10 mL × 3) washing, use anhydrous sodium sulfate
It is dried overnight, filters, remove methylene chloride under reduced pressure, obtain colourless viscous liquid.Crude product is purified through column chromatography（Petroleum ether：Second
Acetoacetic ester=20:1）, 0.026 g of white solid is obtained, as target compound, 51.69 % of yield.1H-NMR (400 MHz,
DMSO-d 6 ) δ (ppm): 7.48 (dd, J = 8.0, 1.7 Hz, 2H, ArH), 7.41~7.22 (m, 18H,
ArH), 4.92 ~ 4.78 (m, 1H, HC (1)), 4.69 ~ 4.61 (m, 7H, PhCH 2 *3,HC(5)), 4.59 (d, J
= 11.4 Hz, 1H, HC(3)), 4.20~4.09 (m, 2H, CH 2OH, HC(2)), 3.34 (tri, J = 10.92
Hz, 1 H, HC(4)), 2.28 (t, J = 7.4 Hz, 2H, CH2), 1.49 (q, J = 6.8 Hz, 2H,
CH2), 1.22 (s, 10H, CH2), 0.85 (d, J=7.1 Hz, 3H, CH3).13C NMR (101 MHz,
Acetone) δ 172.54, 139.07, 138.88, 138.77, 134.76, 132.94, 130.78, 130.73,
128.79, 128.75, 128.27, 128.17, 128.04, 127.94, 127.67, 127.63, 127.46,
127.37, 126.77, 126.52, 124.86, 119.97, 115.85, 115.15, 108.77, 86.93, 83.97,
77.31, 75.93, 75.00, 74.36, 74.25, 72.34, 63.03, 33.64, 33.31, 31.67, 30.66,
24.75, 24.30, 22.40, 13.44。
Using n-nonanoic acid as substituted carboxylic acid, chemical formula is the target compound：
Chemical name for three-O- benzyl -6-O- pelargonyl group -1- deoxidations of 1- thio-phenyls -2,3,4- -β- D- gala sugar esters.
Claims (9)
1. a kind of galactolipin sugar ester base compound donator, it is characterised in that：Compound name for 1- thio-phenyls -2,3,4- three -
O- benzyl -6-O- substituted acyl -1- deoxidations -β- D- gala sugar esters, general structure are：
Wherein, R is the carbochain or aromatic rings that carbon number is 1-14.
2. the preparation method of galactolipin sugar ester base compound donator as described in claim 1, it is characterised in that：Including walking as follows
Suddenly：
Step 1: using galactolipin as raw material, total oxygen acetylation galactolipin is generated under the action of acetylation reagent and alkali；
Step 2: total oxygen acetylation galactolipin is mixed with benzenethiol, catalysts and solvents, compound IV is made in glycosidation,
Its structural formula is：
Step 3: compound IV is mixed with alkali and solvent, deacetylation generation compound V, structural formula is：
Step 4: compound V is mixed with triphenylchloromethane and alkali, reaction generation compound VI, structural formula is：
Step 5: compound VI is mixed with bromobenzyl, alkali and solvent, reaction generation compound VII, structural formula is：
Step 6: compound VII is mixed with acid and solvent, reaction sloughs trityl and obtains compound VIII, structural formula
For：
Step 7: by compound VIII and substituted carboxylic acid, condensing agent, alkali and solvent, reaction sloughs trityl and obtains described half
Lactose sugar ester base compound donator.
3. the preparation method of galactolipin sugar ester base compound donator as claimed in claim 2, it is characterised in that：The step 1
In, by galactolipin, acetylation reagent and alkali according to 1:(5—25)：The mixed in molar ratio of (5-25), in 0-140 DEG C of reaction
At a temperature of reaction 0.5-8 it is small when, the acetylation reagent be acetic anhydride or chloracetyl, the alkali for pyridine, triethylamine or
Sodium acetate.
4. the preparation method of galactolipin sugar ester base compound donator as claimed in claim 2, it is characterised in that：The step 2
In, by total oxygen acetylation galactolipin and benzenethiol, catalysts and solvents according to 1:(1—5) ：(1—25)：Mole of (5-50)
Than mixing, when reaction 0.5-24 is small under 0-140 DEG C of reaction temperature, the catalyst is Fe/I2Or FeI2, solvent is
Dichloromethane, tetrahydrofuran or acetone.
5. the preparation method of galactolipin sugar ester base compound donator as claimed in claim 2, it is characterised in that：The step 3
In, by compound IV, alkali and solvent according to 1:(4—40)：The mixed in molar ratio of (5-50), under 0-50 DEG C of reaction temperature
When reaction 0.5-8 is small, the alkali is K2CO3, NaOH or NaOCH3, solvent is methanol or water.
6. the preparation method of galactolipin sugar ester base compound donator as claimed in claim 2, it is characterised in that：The step 4
In, by compound V, triphenylchloromethane and alkali according to 1:(1—5)：The mixed in molar ratio of (1-25), it is anti-at 0-120 DEG C
When reaction 0.5-24 is small at a temperature of answering, the alkali is pyridine or triethylamine.
7. the preparation method of galactolipin sugar ester base compound donator as claimed in claim 2, it is characterised in that：The step 5
In, by compound VI, bromobenzyl, alkali and solvent according to 1:(4—15)：(4—15)：The mixed in molar ratio of (5-50), 0-
When reaction 0.5-24 is small under 100 DEG C of reaction temperature, the alkali is NaH or CaH2, solvent for n,N-Dimethylformamide,
Tetrahydrofuran or acetone.
8. the preparation method of galactolipin sugar ester base compound donator as claimed in claim 2, it is characterised in that：The step 6
In, by compound VII, acid and solvent according to 1:(1—10)：The mixed in molar ratio of (5-50), in 0-50 DEG C of reaction temperature
It is lower reaction 0.5-8 it is small when, the acid be HCl or p-methyl benzenesulfonic acid, solvent be dichloromethane or methanol.
9. the preparation method of galactolipin sugar ester base compound donator as claimed in claim 2, it is characterised in that：The step 7
In, by compound VIII, substituted carboxylic acid, condensing agent, alkali and solvent according to 1:(1—3)：(1—3)：(2—6)：(5-25)
Mixed in molar ratio, under 0-50 DEG C of reaction temperature react 0.5-24 it is small when, the condensing agent for EDCI/HOBt, BOP,
PyBOP, DCC or CDI, alkali are pyridine, triethylamine or DIEA, and solvent is dichloromethane, tetrahydrofuran or acetone.
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