CN108024985A - 抗微生物剂和抑制海洋生物副溶血弧菌感染引起的疾病的方法 - Google Patents
抗微生物剂和抑制海洋生物副溶血弧菌感染引起的疾病的方法 Download PDFInfo
- Publication number
- CN108024985A CN108024985A CN201680052993.4A CN201680052993A CN108024985A CN 108024985 A CN108024985 A CN 108024985A CN 201680052993 A CN201680052993 A CN 201680052993A CN 108024985 A CN108024985 A CN 108024985A
- Authority
- CN
- China
- Prior art keywords
- antimicrobial
- propylgallate
- vibrio parahaemolytious
- concentration
- infection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000000845 anti-microbial effect Effects 0.000 title claims abstract description 44
- 241000607598 Vibrio Species 0.000 title claims abstract description 25
- 238000000034 method Methods 0.000 title claims abstract description 19
- 201000010099 disease Diseases 0.000 title claims abstract description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 10
- 208000015181 infectious disease Diseases 0.000 title claims abstract description 9
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 claims abstract description 80
- 235000010388 propyl gallate Nutrition 0.000 claims abstract description 40
- 239000000473 propyl gallate Substances 0.000 claims abstract description 39
- 229940075579 propyl gallate Drugs 0.000 claims abstract description 39
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 241000607272 Vibrio parahaemolyticus Species 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 abstract description 3
- 230000003115 biocidal effect Effects 0.000 description 16
- 230000000052 comparative effect Effects 0.000 description 14
- WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallyl group Chemical group C1(=C(C(=CC=C1)O)O)O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 description 14
- 229960005091 chloramphenicol Drugs 0.000 description 8
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 6
- 239000012530 fluid Substances 0.000 description 6
- 239000002609 medium Substances 0.000 description 6
- 244000005700 microbiome Species 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 235000015097 nutrients Nutrition 0.000 description 6
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 5
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 5
- 239000004255 Butylated hydroxyanisole Substances 0.000 description 5
- 241000238557 Decapoda Species 0.000 description 5
- 239000004098 Tetracycline Substances 0.000 description 5
- 238000009360 aquaculture Methods 0.000 description 5
- 244000144974 aquaculture Species 0.000 description 5
- 235000019282 butylated hydroxyanisole Nutrition 0.000 description 5
- 229940043253 butylated hydroxyanisole Drugs 0.000 description 5
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 5
- 235000005487 catechin Nutrition 0.000 description 5
- 229950001002 cianidanol Drugs 0.000 description 5
- 229940079877 pyrogallol Drugs 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 229960002180 tetracycline Drugs 0.000 description 5
- 229930101283 tetracycline Natural products 0.000 description 5
- 235000019364 tetracycline Nutrition 0.000 description 5
- 150000003522 tetracyclines Chemical class 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 3
- 230000002411 adverse Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 235000013373 food additive Nutrition 0.000 description 3
- 239000002778 food additive Substances 0.000 description 3
- 238000011081 inoculation Methods 0.000 description 3
- 206010018910 Haemolysis Diseases 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000034994 death Effects 0.000 description 2
- 231100000517 death Toxicity 0.000 description 2
- 230000008588 hemolysis Effects 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 241000251468 Actinopterygii Species 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 101710093543 Probable non-specific lipid-transfer protein Proteins 0.000 description 1
- 206010047400 Vibrio infections Diseases 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 210000000514 hepatopancreas Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- GOLXNESZZPUPJE-UHFFFAOYSA-N spiromesifen Chemical compound CC1=CC(C)=CC(C)=C1C(C(O1)=O)=C(OC(=O)CC(C)(C)C)C11CCCC1 GOLXNESZZPUPJE-UHFFFAOYSA-N 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
- A01N37/38—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system
- A01N37/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system having at least one carboxylic group or a thio analogue, or a derivative thereof, and one oxygen or sulfur atom attached to the same aromatic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Pest Control & Pesticides (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Agronomy & Crop Science (AREA)
- Emergency Medicine (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Fodder In General (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015-200735 | 2015-10-09 | ||
| JP2015200735A JP6336424B2 (ja) | 2015-10-09 | 2015-10-09 | 抗菌剤および海洋生物の腸炎ビブリオの感染による疾病を抑制する方法 |
| PCT/JP2016/080088 WO2017061630A1 (ja) | 2015-10-09 | 2016-10-11 | 抗菌剤および海洋生物の腸炎ビブリオの感染による疾病を抑制する方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108024985A true CN108024985A (zh) | 2018-05-11 |
Family
ID=58487830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680052993.4A Pending CN108024985A (zh) | 2015-10-09 | 2016-10-11 | 抗微生物剂和抑制海洋生物副溶血弧菌感染引起的疾病的方法 |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP6336424B2 (https=) |
| CN (1) | CN108024985A (https=) |
| WO (1) | WO2017061630A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115400105A (zh) * | 2022-10-12 | 2022-11-29 | 湖北省农业科学院畜牧兽医研究所 | 焦棓酸在制备抗马链球菌兽疫亚种药物中的应用 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112450355A (zh) * | 2020-11-23 | 2021-03-09 | 大连工业大学 | 一种抗菌肽Cm-CATH2抑制海产品中副溶血性弧菌的应用及用途 |
| CN115501214B (zh) * | 2022-10-14 | 2023-09-22 | 湖北省农业科学院畜牧兽医研究所 | 焦棓酸与磺胺异恶唑组合物及其在抑制猪链球菌2型中的应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006306836A (ja) * | 2005-01-11 | 2006-11-09 | Microbiotech:Kk | 抗ウイルス・抗炎症作用薬剤組成物 |
| CN104872416A (zh) * | 2015-05-05 | 2015-09-02 | 中国林业科学研究院林产化学工业研究所 | 五倍子提取物的应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1143441A (ja) * | 1997-07-29 | 1999-02-16 | Ichimaru Pharcos Co Ltd | 魚介類の疾病予防治療剤 |
| JP4571783B2 (ja) * | 2003-04-14 | 2010-10-27 | 林原 健 | 抗微生物剤 |
| CA2672538A1 (en) * | 2006-12-28 | 2008-07-10 | Microbiotech Inc. | Pharmaceutical compositions of alkyl gallates |
-
2015
- 2015-10-09 JP JP2015200735A patent/JP6336424B2/ja active Active
-
2016
- 2016-10-11 CN CN201680052993.4A patent/CN108024985A/zh active Pending
- 2016-10-11 WO PCT/JP2016/080088 patent/WO2017061630A1/ja not_active Ceased
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006306836A (ja) * | 2005-01-11 | 2006-11-09 | Microbiotech:Kk | 抗ウイルス・抗炎症作用薬剤組成物 |
| CN104872416A (zh) * | 2015-05-05 | 2015-09-02 | 中国林业科学研究院林产化学工业研究所 | 五倍子提取物的应用 |
Non-Patent Citations (1)
| Title |
|---|
| FUMI YAMANAKA ET AL.: "Antibacterial Effects of Guava Tannins and Related Polyphenols on Vibrio and Aeromonas Species", 《NATURAL PRODUCT COMMUNICATIONS》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115400105A (zh) * | 2022-10-12 | 2022-11-29 | 湖北省农业科学院畜牧兽医研究所 | 焦棓酸在制备抗马链球菌兽疫亚种药物中的应用 |
| CN115400105B (zh) * | 2022-10-12 | 2023-08-22 | 湖北省农业科学院畜牧兽医研究所 | 焦棓酸在制备抗马链球菌兽疫亚种药物中的应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2017071583A (ja) | 2017-04-13 |
| JP6336424B2 (ja) | 2018-06-06 |
| WO2017061630A1 (ja) | 2017-04-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180511 |