CN107847440B - 改善水不溶性或微水溶性药物的水溶性的方法 - Google Patents

改善水不溶性或微水溶性药物的水溶性的方法 Download PDF

Info

Publication number
CN107847440B
CN107847440B CN201680039722.5A CN201680039722A CN107847440B CN 107847440 B CN107847440 B CN 107847440B CN 201680039722 A CN201680039722 A CN 201680039722A CN 107847440 B CN107847440 B CN 107847440B
Authority
CN
China
Prior art keywords
water
dexpanthenol
concentration
aqueous solvent
insoluble
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201680039722.5A
Other languages
English (en)
Chinese (zh)
Other versions
CN107847440A (zh
Inventor
A·格拉索尔
E·普里斯赫-格拉索尔
A·博登泰希
M·莫罗库蒂-库尔兹
S·纳克维斯希
C·坎茨
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Marinomed Biotech AG
Original Assignee
Marinomed Biotech AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Marinomed Biotech AG filed Critical Marinomed Biotech AG
Publication of CN107847440A publication Critical patent/CN107847440A/zh
Application granted granted Critical
Publication of CN107847440B publication Critical patent/CN107847440B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0291—Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/602—Glycosides, e.g. rutin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/10—General cosmetic use

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Birds (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Anesthesiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
CN201680039722.5A 2015-07-16 2016-07-15 改善水不溶性或微水溶性药物的水溶性的方法 Active CN107847440B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201514801578A 2015-07-16 2015-07-16
US14/801578 2015-07-16
PCT/EP2016/066999 WO2017009480A1 (en) 2015-07-16 2016-07-15 Method for improving aqueous solubility of water-insoluble or slightly water-soluble drugs

Publications (2)

Publication Number Publication Date
CN107847440A CN107847440A (zh) 2018-03-27
CN107847440B true CN107847440B (zh) 2021-06-25

Family

ID=56418519

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680039722.5A Active CN107847440B (zh) 2015-07-16 2016-07-15 改善水不溶性或微水溶性药物的水溶性的方法

Country Status (29)

Country Link
EP (1) EP3324933B1 (https=)
JP (1) JP6836825B2 (https=)
KR (1) KR102615005B1 (https=)
CN (1) CN107847440B (https=)
AU (1) AU2016293125B2 (https=)
CA (1) CA2992376C (https=)
CL (1) CL2018000032A1 (https=)
CO (1) CO2018001460A2 (https=)
CY (1) CY1124322T1 (https=)
DK (1) DK3324933T3 (https=)
EA (1) EA036233B1 (https=)
ES (1) ES2844581T3 (https=)
HR (1) HRP20210333T1 (https=)
HU (1) HUE053116T2 (https=)
IL (1) IL256882B (https=)
LT (1) LT3324933T (https=)
MA (1) MA42472B1 (https=)
MX (1) MX379341B (https=)
MY (1) MY196065A (https=)
NZ (1) NZ738592A (https=)
PH (1) PH12018500042A1 (https=)
PL (1) PL3324933T3 (https=)
PT (1) PT3324933T (https=)
RS (1) RS61561B1 (https=)
SA (1) SA518390688B1 (https=)
SI (1) SI3324933T1 (https=)
UA (1) UA123312C2 (https=)
WO (1) WO2017009480A1 (https=)
ZA (1) ZA201708594B (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108143713A (zh) * 2018-01-04 2018-06-12 南方医科大学南方医院 一种增加羟喜树碱溶解度的方法
US12377046B1 (en) 2019-04-24 2025-08-05 Wellomics LLC Delivery system matrices
CN110074385B (zh) * 2019-05-21 2022-05-31 绥化市蓝源生物工程有限公司 一种生物碱溶解纳他霉素的生物溶剂及其应用
KR20220022829A (ko) * 2020-08-19 2022-02-28 주식회사 모든바이오 글리시리진 및 수용성 약물을 포함하는 나노 입자, 이를 포함하는 약제학적 조성물 및 이들의 제조 방법
CN114588118B (zh) * 2022-01-25 2023-05-23 武汉爱民制药股份有限公司 一种注射用七叶皂苷钠复方制剂
KR102922176B1 (ko) * 2022-07-08 2026-02-04 한국생산기술연구원 소수성 약물 전달을 위한 금-히알루론산 나노입자의 제조방법
EP4431082A1 (en) * 2023-03-13 2024-09-18 Marinomed Biotech AG Aqueous composition comprising budesonide
EP4516289A1 (en) 2023-08-30 2025-03-05 SPH Sine Pharmaceutical Laboratories Co., Ltd Antiviral nasal spray comprising favipiravir
CN117562911B (zh) * 2023-12-07 2024-06-04 海南医学院 化合物tigloside在制备治疗和/或预防骨关节炎药物中的用途
WO2025133675A1 (en) * 2023-12-20 2025-06-26 Melikoglu, Ahmet Method for producing nasal formulation comprising aescin and rutin
EP4696300A1 (en) 2024-08-14 2026-02-18 Marinomed Biotech AG Aqueous composition comprising fluticasone
KR102907892B1 (ko) * 2025-01-09 2026-01-12 주식회사 한바이오 가용성을 높인 피레스로이드계의 보건용 스프레이 살충제 제조방법

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002074238A2 (en) * 2001-02-16 2002-09-26 Lavipharm Laboratories Inc. Water soluble and palatable complexes
CN103271891A (zh) * 2013-04-28 2013-09-04 福建南方制药股份有限公司 人参皂苷纳米胶束及其制备方法、应用和药物组合物
WO2014163558A1 (en) * 2013-04-01 2014-10-09 Moreinx Ab Nanoparticles, composed of sterol and saponin from quillaja saponaria molina process for preparation and use thereof as carrier for amphipatic of hydrphobic molecules in fields of medicine including cancer treatment and food related compounds

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1119957A (en) 1979-12-04 1982-03-16 Martin Whitefield Steroid compositions
US4782047A (en) 1986-05-22 1988-11-01 Syntex Pharmaceuticals International Ltd. Aqueous steroid formulations for nasal administration
US4868170A (en) 1987-11-13 1989-09-19 E. R. Squibb & Sons, Inc. Steriod lotion formulation
JPH1025255A (ja) * 1996-07-11 1998-01-27 Taisho Pharmaceut Co Ltd 溶解性の改善された難溶性薬剤
FR2799369B1 (fr) 1999-10-08 2001-12-21 Oreal Association d'escine et de sulfate de dextran et son utilisation
JP4000283B2 (ja) * 2002-08-07 2007-10-31 丸善製薬株式会社 甘草油性抽出物の可溶化組成物、並びに飲料、液状調味料、化粧品及び医薬部外品
US7897587B2 (en) 2004-09-03 2011-03-01 Nycomed Us Inc. Topical dermatological formulations and use thereof
JP5128801B2 (ja) * 2006-10-16 2013-01-23 フロイント産業株式会社 高水分散性粉末とその製造方法
JP6265624B2 (ja) * 2012-05-11 2018-01-24 ロート製薬株式会社 ルリコナゾール含有外用医薬組成物
CN103520081B (zh) * 2013-09-27 2015-10-28 无限极（中国）有限公司 一种调节皮肤免疫力、延缓皮肤老化的外用护肤品

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002074238A2 (en) * 2001-02-16 2002-09-26 Lavipharm Laboratories Inc. Water soluble and palatable complexes
WO2014163558A1 (en) * 2013-04-01 2014-10-09 Moreinx Ab Nanoparticles, composed of sterol and saponin from quillaja saponaria molina process for preparation and use thereof as carrier for amphipatic of hydrphobic molecules in fields of medicine including cancer treatment and food related compounds
CN103271891A (zh) * 2013-04-28 2013-09-04 福建南方制药股份有限公司 人参皂苷纳米胶束及其制备方法、应用和药物组合物

Also Published As

Publication number Publication date
UA123312C2 (uk) 2021-03-17
BR112018000613A2 (pt) 2018-09-18
IL256882B (en) 2021-12-01
KR102615005B1 (ko) 2023-12-18
HK1253027A1 (zh) 2019-06-06
DK3324933T3 (da) 2021-01-18
PL3324933T3 (pl) 2021-08-02
IL256882A (en) 2018-03-29
EP3324933A1 (en) 2018-05-30
MY196065A (en) 2023-03-13
CY1124322T1 (el) 2022-07-22
PH12018500042A1 (en) 2018-07-09
ES2844581T3 (es) 2021-07-22
HRP20210333T1 (hr) 2021-04-16
ZA201708594B (en) 2019-06-26
EA036233B1 (ru) 2020-10-16
CA2992376A1 (en) 2017-01-19
HUE053116T2 (hu) 2021-06-28
EP3324933B1 (en) 2020-12-16
JP2019501861A (ja) 2019-01-24
CL2018000032A1 (es) 2018-11-16
WO2017009480A1 (en) 2017-01-19
EA201890194A1 (ru) 2018-10-31
CN107847440A (zh) 2018-03-27
CO2018001460A2 (es) 2018-05-10
SA518390688B1 (ar) 2022-03-13
SI3324933T1 (sl) 2021-04-30
MX2018000286A (es) 2018-02-19
AU2016293125B2 (en) 2021-05-06
MX379341B (es) 2025-03-10
CA2992376C (en) 2023-06-20
MA42472A (fr) 2018-05-30
NZ738592A (en) 2021-12-24
JP6836825B2 (ja) 2021-03-03
AU2016293125A1 (en) 2018-01-18
RS61561B1 (sr) 2021-04-29
KR20180054569A (ko) 2018-05-24
PT3324933T (pt) 2021-01-28
MA42472B1 (fr) 2021-02-26
LT3324933T (lt) 2021-04-26

Similar Documents

Publication Publication Date Title
CN107847440B (zh) 改善水不溶性或微水溶性药物的水溶性的方法
KR100359556B1 (ko) 티릴라자드의조용매비경구제
WO2004105694A3 (en) Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
UA119324C2 (uk) Композиції фармацевтично активних речовин, що містять моноетиловий ефір діетиленгліколю або інші алкільні похідні
EP3267978B1 (en) Topical compositions comprising a corticosteroid
JP2022524019A (ja) 末梢神経障害の処置のための局所製剤
EP3247329B3 (en) Injectable pharmaceutical composition comprising dexamethasone sodium phosphate
DE602004013035T2 (de) Suspension von loteprednol-etabonat und tobramycin für die topische ophthalmische anwendung
KR101248503B1 (ko) 녹차 잎의 열수추출물 및 녹차 잎의 에탄올추출물을 유효성분으로 함유하는 아토피 피부염 개선용 조성물
US11510859B2 (en) Method for improving aqueous solubility of water-insoluble or slightly water-soluble drugs
WO2013174854A1 (en) Terpene extract for the treatment of hair loss
CN120693163A (zh) 双嘧达莫及其制剂在防治特应性皮炎中的应用
US20140348910A1 (en) Topical Formulations Including Lipid Microcapsule Delivery Vehicles and Their Uses
JP2019048890A (ja) 泡状外用医薬組成物
EP3104839B1 (en) Topical formulations of heparin
HK1253027B (zh) 改善水不溶性或微水溶性药物的水溶性的方法
WO2007086582A1 (ja) ２２－オキサ－１α,２５－ジヒドロキシビタミンＤ3を含有する水中油型乳剤性ローション剤およびそれを用いた皮膚疾患の治療方法
BR112018000613B1 (pt) Método para melhorar a solubilidade aquosa de fármacos insolúveis em água ou levemente solúveis em água
EP3893845B1 (en) Composition comprising dutasteride
KR20150095772A (ko) 아토피성 피부염 치료를 위한 피도티모드의 사용
KR20070101134A (ko) 발레르산 아세트산 프레드니졸론을 함유하는 ｏ/ｗ 형 유화제제
HK40056968A (en) Injectable pharmaceutical composition comprising dexamethasone sodium phosphate
KR100738021B1 (ko) 은행엽 엑스 고농도 함유 주사제
HK1231757B (en) Topical formulations of heparin

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1253027

Country of ref document: HK

GR01 Patent grant
GR01 Patent grant