CN107802793B - Epimedium and Sichuan granules and preparation method thereof - Google Patents

Epimedium and Sichuan granules and preparation method thereof Download PDF

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CN107802793B
CN107802793B CN201711296784.7A CN201711296784A CN107802793B CN 107802793 B CN107802793 B CN 107802793B CN 201711296784 A CN201711296784 A CN 201711296784A CN 107802793 B CN107802793 B CN 107802793B
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ginseng
traditional chinese
chinese medicine
radix
root
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CN107802793A (en
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喻朝辉
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Sichuan Taile Pharmaceutical Co ltd
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Sichuan Taile Pharmaceutical Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/29Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A61K36/296Epimedium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/02Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
    • A61K35/10Peat; Amber; Turf; Humus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/648Myriapods, e.g. centipedes or millipedes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11Pteridophyta or Filicophyta (ferns)
    • A61K36/12Filicopsida or Pteridopsida
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/21Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/289Vladimiria
    • AHUMAN NECESSITIES
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/68Plantaginaceae (Plantain Family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/716Clematis (leather flower)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736Prunus, e.g. plum, cherry, peach, apricot or almond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/756Phellodendron, e.g. corktree
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9066Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/15Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • AHUMAN NECESSITIES
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    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/17Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The invention discloses epimedium-radix-notoginseng-radix-curcumae-radix-polygoni multiflori, ginseng, semen plantaginis, peach kernel, pseudo-ginseng, radix curcumae, fenugreek, radix aucklandiae, caulis clematidis armandii, amber, centipede, spora lygodii, golden cypress and radix cyathulae are extracted by a method combining picking, selecting, washing, cutting, drying, crushing, damp-heat sterilization and decoction, so that active ingredients in medicinal materials can be completely extracted, higher medicinal material utilization rate and extraction rate are ensured, and medicinal material residues are; the invention uses a damp-heat sterilization method to find that the effective components in the traditional Chinese medicinal materials are obviously improved; the extraction method has the advantages of low extraction temperature, small solvent consumption and the like, saves a large amount of cost for large-scale production, and can effectively reduce energy consumption so as to protect the environment.

Description

Epimedium and Sichuan granules and preparation method thereof
Technical Field
The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine for treating prostatitis/hypertrophy.
Technical Field
The prostatauxe and prostatitis are common diseases and frequently encountered diseases of middle-aged and old men, are clinically common, and are divided into bacterial prostatitis and non-bacterial prostatitis. Bacterial prostatitis is also classified into acute bacterial prostatitis and chronic bacterial prostatitis. Bacterial prostatitis is mostly caused by retrograde infection of urethra or blood infection, and the pathogenic bacteria are mostly gram-negative bacilli or pseudomonas. Acute prostatitis is characterized by acute onset, fever, intolerance of cold, soreness and weakness of waist and knees, vexation, burning sensation in urination, urgent urination, odynuria, frequent urination and inflammatory secretion in urethra. Or difficulty in urination and urinary retention. The infection can cause spermatitis, epididymitis and septicemia. Besides the symptoms of the urethra and the prostatic fluid, chronic prostatitis is often accompanied by soreness and weakness of waist and knees, moist pudendum, white drip after urination, lower abdominal fullness or vague pain, thin urine, frequent micturition, incomplete urine, urine waiting, urine bifurcation, urine retention, sexual impotence, premature ejaculation, spermatorrhea, sexual apathy and other sexual dysfunction, and is often accompanied by anxiety, depressed mood, insomnia, dreaminess, dizziness, fatigue and the like in the aspect of spirit; the disease is difficult to cure due to the stagnation of damp-heat and qi deficiency and yang sinking. At present, the treatment of acute prostatitis is carried out by adopting antibacterial drugs such as penicillin, streptomycin, ampicillin, cefam penicillin and the like; the chronic bacterial prostatitis is treated by the medicines such as erythromycin, doxycycline, class B spiramycin and the like. These drugs have significant side effects and are highly dependent, resulting in larger and larger drug use levels, which can lead to vicious cycles.
In the prior art, the preparation method used in the process of preparing the traditional Chinese medicine preparation for treating prostatitis/hypertrophy only simply decocts a plurality of traditional Chinese medicines with water, and the preparation method can not well release important effective components, thereby not only causing the waste of the Chinese herbal medicines, but also influencing the treatment effect. For example, chinese patent 2013101525638 discloses a Chinese medicine for treating prostatitis, which is prepared by simply grinding realgar, lygodium japonicum, aucklandia root, plantain seed and dried rehmannia root into powder for administration. The effective components of the traditional Chinese medicine prepared by the method can not be well absorbed and utilized, so that the drug effect can not be well exerted, and the waste of the medicine is caused. For another example, chinese patent 2016104344021 discloses a Chinese medicine for treating prostatic hyperplasia, which is prepared by decocting ancient yam, moschus, rhizoma cimicifugae, rhizoma nardostachyos, white back maple, selaginella tamariscina, white peony root, lysimachia christinae hance, cutworm and water in a certain proportion. The effective components of the traditional Chinese medicine prepared by the method can not be well dissolved in water, so that the effective components of the traditional Chinese medicine can not be well released, and the waste of the traditional Chinese medicine components is caused.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide the traditional Chinese medicine for treating prostatitis/hypertrophy, which has high drug effect, quick response and good curative effect.
In order to achieve the purpose, on one hand, the invention provides epimedium-rhizoma traditional Chinese medicine granules, which comprise the following components in parts by weight: 1000g of epimedium 500-.
Preferably, the invention provides epimedium-III traditional Chinese medicine granules, the formula of which comprises the following components: 800g of epimedium 600-containing material, 180g of ground beetle 120-containing material, 180g of ginseng 120-containing material, 800g of plantain seed 400-containing material, 500g of peach kernel 250-containing material, 40-80g of pseudo-ginseng, 80-150g of radix curcumae, 600g of fenugreek 400-containing material, 80-200g of common vladimiria root, 700g of clematis stem 400-containing material, 15-40g of amber, 15-40g of centipede, 30-70g of climbing fern spore, 500g of phellodendron 300-containing material and 700g of medicinal cyathula root 300-containing material.
Further preferably, the invention provides epimedium-III traditional Chinese medicine granules, the formula of which comprises the following components: 700g of epimedium 650-charge, 150g of ground beetle 130-charge, 150g of ginseng 130-charge, 600g of plantain seed 500-charge, 400g of peach kernel 300-charge, 50-70g of pseudo-ginseng, 140g of curcuma aromatica 120-charge, 550g of fenugreek seed 450-charge, 150g of common vladimiria root 120-charge, 600g of clematis stem 450-charge, 20-30g of amber, 20-30g of centipede, 50-60g of lygodium japonicum, 450g of phellodendron amurense 400-charge and 600g of medicinal cyathula root 400-charge.
In a specific embodiment, the recipe of the epimedium-rhizoma-radix-aconiti-tuber traditional Chinese medicine granule provided by the invention comprises the following components: 650g of epimedium herb, 130g of ground beeltle, 130g of ginseng, 600g of plantain seed, 400g of peach seed, 70g of pseudo-ginseng, 140g of turmeric root-tuber, 550g of fenugreek, 150g of common vladimiria root, 600g of clematis stem, 30g of amber, 20g of centipede, 50g of lygodium japonicum, 400g of amur corktree bark and 400g of medicinal cyathula root.
In another specific embodiment, the recipe of the epimedium-radix-notoginseng-monkshood traditional Chinese medicine granule provided by the invention comprises the following components: 700g of epimedium herb, 150g of ground beeltle, 150g of ginseng, 600g of plantain seed, 400g of peach seed, 70g of pseudo-ginseng, 140g of turmeric root-tuber, 550g of fenugreek, 150g of common vladimiria root, 600g of clematis stem, 30g of amber, 30g of centipede, 60g of lygodium japonicum, 450g of amur corktree bark and 600g of medicinal cyathula root.
In a preferred specific embodiment, the recipe of the epimedium-radix-notoginseng-monkshood traditional Chinese medicine granule provided by the invention comprises the following components: 667g of epimedium herb, 133g of ground beeltle, 134g of ginseng, 583g of plantain seed, 334g of peach seed, 58g of pseudo-ginseng, 133g of turmeric root-tuber, 500g of fenugreek, 133g of common vladimiria root, 500g of clematis stem, 25g of amber, 25g of centipede, 58g of lygodium japonicum, 417g of amur corktree bark and 500g of medicinal cyathula root.
In another preferred embodiment, the formulation of the epimedium-radix-notoginseng-monkshood traditional Chinese medicine granule provided by the invention comprises the following components: 685g of epimedium herb, 148g of ground beeltle, 145g of ginseng, 594g of plantain seed, 358g of peach seed, 65g of pseudo-ginseng, 138g of turmeric root-tuber, 537g of fenugreek, 148g of common vladimiria root, 556g of clematis stem, 28g of amber, 28g of centipede, 58g of lygodium japonicum, 436g of golden cypress and 552g of medicinal cyathula root.
On the other hand, the invention provides a preparation method of the epimedium-radix-notoginseng-rhizoma-traditional Chinese medicine granules. The method comprises the following steps:
(1) selecting, washing, cutting and drying ginseng, pseudo-ginseng, radix curcumae, radix aucklandiae and amber in the formula, preparing the dried medicinal materials into traditional Chinese medicine decoction pieces, carrying out superfine grinding and sieving on the prepared traditional Chinese medicine decoction pieces to respectively obtain corresponding medicinal material powder, and sterilizing for later use;
(2) sterilizing the ginseng, pseudo-ginseng, turmeric root-tuber, common vladimiria root and amber powder obtained in the step (1) respectively for later use;
(3) selecting, washing, cutting and drying ten medicinal materials except the ginseng, the pseudo-ginseng, the radix curcumae, the common vladimiria root and the amber powder in the formula, and sterilizing the dried medicinal materials to prepare traditional Chinese medicine decoction pieces for later use;
(4) soaking the Chinese medicinal decoction pieces obtained in the step (3) in water, decocting for two times, removing residues, mixing the decoctions, concentrating to obtain fluid extract with relative density of about 1.10 (measured at 70 deg.C), and collecting the extract to obtain the final product named as YANHUNSAICHUAN granule fluid extract;
(5) and (3) uniformly mixing the epimedium-radix-notoginseng granule clear paste obtained in the step (4) and the sterilized ginseng, pseudo-ginseng, radix curcumae, radix aucklandiae and amber powder obtained in the step (2) with steviosin to prepare a base material, and granulating and finishing the base material by adopting a one-step method.
The drying in the step (1) and the step (3) is one of vacuum drying or hot air circulation drying under the condition of alternately irradiating medium and long wavelength ultraviolet rays; preferably, the vacuum drying is carried out under the condition of alternately irradiating medium-wave ultraviolet rays and long-wave ultraviolet rays;
wherein the vacuum drying temperature is room temperature, and the drying time is 12-24 h;
wherein, the mixture is sieved by a 200-mesh sieve after being subjected to superfine grinding;
wherein, the ultraviolet radiation is 320-400 nm wavelength, the radiation is 10-40min and 275-320nm medium wave, the radiation is alternatively radiated for 2-3 times for 8-20 min;
wherein the hot air circulation drying temperature is 70-80 deg.C, and the drying time is 3-5 h.
The sterilization in the steps (1) - (3) is carried out in a horizontal rectangular pressure steam sterilizer, the thickness of a spreading plate is 3-5cm, the steam pressure is 0.15Mpa, the sterilization is carried out for 30min at 115 ℃, and the sterilization is carried out for 10-15 min.
The soaking in the step (4) is normal-temperature soaking or high-temperature ultrasonic soaking, preferably high-temperature ultrasonic soaking; soaking for 0.5-1h at normal temperature; the high temperature soaking temperature is 80-100 deg.C, the soaking time is 1-3h, and the ultrasonic time is 15 + -5 min.
In the step (4), the first time of decoction is 2 hours by adding 8 times of water, and the second time of decoction is 1 hour by adding 6 times of water.
The extraction method of the invention, namely the extraction method combining irradiation-drying-ultrasound-decoction, is to thin or break cell walls under the condition of ultraviolet irradiation, and then to decoct and ultrasonically react after picking, selecting, washing, cutting and drying to prepare the traditional Chinese medicine decoction pieces so as to dissolve out the effective components along with the extracting solution, thereby facilitating the direct and easy absorption of the effective components.
The invention uses the extraction method combining irradiation-drying-ultrasonic-decoction and the preparation method combining part of crude drug powder and part of Chinese medicine extract, not only can completely extract the active ingredients in the medicinal materials, ensures higher utilization rate and extraction rate of the medicinal materials, and can effectively reduce the medicinal material residues. The extraction method has the advantages of low extraction temperature, small solvent consumption and the like, can save a large amount of cost for mass production, is beneficial to energy conservation and environmental protection, and provides a new idea for the extraction process of the traditional Chinese medicinal materials.
Drawings
FIG. 1 is a flow chart of the epimedium and sichuan aconite granules and the preparation method thereof
Detailed Description
The invention will be further illustrated with reference to the following specific examples. These examples are intended to illustrate the invention and are not intended to limit the scope of the invention.
The sterilizing device used in the invention is a YXQ.WF22 type horizontal rectangular pressure steam sterilizer; purchased from henan genuine xin medical devices limited.
Example 1 Epimedium grains and process for producing the same
The formula is as follows: 667g of epimedium herb, 133g of ground beeltle, 134g of ginseng, 583g of plantain seed, 334g of peach seed, 58g of pseudo-ginseng, 133g of turmeric root-tuber, 500g of fenugreek, 133g of common vladimiria root, 500g of clematis stem, 25g of amber, 25g of centipede, 58g of lygodium japonicum, 417g of amur corktree bark and 500g of medicinal cyathula root.
The preparation method comprises the following steps: (1) irradiating the ginseng, the pseudo-ginseng, the radix curcumae, the radix aucklandiae and the amber in the formula for 3 times by using a wavelength of 320-400 nm and a medium wave of 275-320nm alternately for 15 min; vacuum drying under irradiation of long wave, medium wave and long wave for 15 hr, making dried medicinal materials into Chinese medicinal decoction pieces, micronizing, sieving with 200 mesh sieve to obtain corresponding medicinal material powder, sterilizing at 115 deg.C under 0.15Mpa steam pressure for 30min, and drying for 15 min;
(2) spreading the powder of Ginseng radix, Notoginseng radix, radix Curcumae, radix aucklandiae and Succinum obtained in step (1) on a sterilizing tray with a thickness of 5cm, sterilizing at 115 deg.C under 0.15Mpa steam pressure for 30min, and drying for 15 min;
(3) irradiating the ten medicinal materials except the ginseng, the pseudo-ginseng, the curcuma aromatica, the radix aucklandiae and the amber powder in the formula for 3 times by using a wavelength of 320-400 nm and a medium wave of 275-320nm alternately for 15 min; vacuum drying under long wave-medium wave-long wave irradiation for 15 hr, sterilizing at 115 deg.C under 0.15Mpa steam pressure for 30min, and drying for 15min to obtain Chinese medicinal decoction pieces;
(4) soaking the Chinese medicinal decoction pieces subjected to ultrasonic treatment obtained in the step (3) in water at 100 ℃ for 1h, performing ultrasonic treatment for 15min, then performing decoction twice, adding 8 times of water for decoction for 2h for the first time, adding 6 times of water for decoction for 1h for the second time, discarding dregs of a decoction, combining liquid medicines decocted twice, concentrating to obtain a clear paste with the relative density of about 1.10 (measured at 70 ℃), and naming the obtained paste as epimedium-rhizoma-III-granule clear paste;
(5) and (3) uniformly mixing the epimedium-radix-notoginseng granule clear paste obtained in the step (4) and the sterilized ginseng, pseudo-ginseng, radix curcumae, radix aucklandiae and amber powder obtained in the step (2) with steviosin to prepare a base material, and granulating and finishing the base material by adopting a one-step method.
Example 2 Epimedium grains and preparation thereof
The formula is as follows: 650g of epimedium herb, 130g of ground beeltle, 130g of ginseng, 600g of plantain seed, 400g of peach seed, 70g of pseudo-ginseng, 140g of turmeric root-tuber, 550g of fenugreek, 150g of common vladimiria root, 600g of clematis stem, 30g of amber, 20g of centipede, 50g of lygodium japonicum, 400g of amur corktree bark and 400g of medicinal cyathula root.
The preparation method comprises the following steps: changing the long wave irradiation time of the step (2) in the embodiment 1 to 20min and the medium wave irradiation time to 10 min; adding water in the step (3) to soak at 90 ℃ for 1h, and immediately performing ultrasonic treatment for 10 min; the other steps are the same as in example 1.
Example 3 Epimedium grains and preparation thereof
The formula is as follows: 700g of epimedium herb, 150g of ground beeltle, 150g of ginseng, 600g of plantain seed, 400g of peach seed, 70g of pseudo-ginseng, 140g of turmeric root-tuber, 550g of fenugreek, 150g of common vladimiria root, 600g of clematis stem, 30g of amber, 30g of centipede, 60g of lygodium japonicum, 450g of amur corktree bark and 600g of medicinal cyathula root.
The preparation method comprises the following steps: the long wave irradiation time in the step (2) in the embodiment 1 is changed to 15min, and the medium wave irradiation time is changed to 10 min; soaking the mixture obtained in the step (3) in water at 80 ℃ for 2h, and immediately performing ultrasonic treatment for 20 min; the other steps are the same as in example 1.
Example 4 Epimedium grains and preparation thereof
The formula is as follows: 685g of epimedium herb, 148g of ground beeltle, 145g of ginseng, 594g of plantain seed, 358g of peach seed, 65g of pseudo-ginseng, 138g of turmeric root-tuber, 537g of fenugreek, 148g of common vladimiria root, 556g of clematis stem, 28g of amber, 28g of centipede, 58g of lygodium japonicum, 436g of golden cypress and 552g of medicinal cyathula root.
The preparation method comprises the following steps: changing the long wave irradiation time of the step (2) in the embodiment 1 to 10min, and changing the medium wave irradiation time to 8 min; adding water in the step (3) to soak at 85 ℃, immediately performing ultrasonic treatment for 15min after 1.5 h; the other steps are the same as in example 1.
Example 5 Epimedium grains and preparation thereof
The formula is as follows: 500g of epimedium herb, 100g of ground beeltle, 100g of ginseng, 300g of plantain seed, 200g of peach seed, 20g of pseudo-ginseng, 50g of turmeric root-tuber, 300g of fenugreek, 50g of common vladimiria root, 300g of clematis stem, 10g of amber, 10g of centipede, 20g of lygodium japonicum, 200g of amur corktree bark and 200g of medicinal cyathula root.
The preparation method comprises the following steps: changing the long wave irradiation time of the step (2) in the embodiment 1 to 25min, and changing the medium wave irradiation time to 12 min; adding water in the step (3) to soak at 90 ℃ for 2h, and immediately performing ultrasonic treatment for 18 min; the other steps are the same as in example 1.
Example 6 Epimedium grains and preparation thereof
The formula is as follows: 1000g of epimedium herb, 200g of ground beeltle, 200g of ginseng, 1000g of plantain seed, 600g of peach seed, 100g of pseudo-ginseng, 200g of turmeric root-tuber, 800g of fenugreek, 250g of common vladimiria root, 800g of clematis stem, 50g of amber, 50g of centipede, 80g of lygodium japonicum, 600g of amur corktree bark and 800g of medicinal cyathula root.
The preparation method comprises the following steps: the long wave irradiation time in the step (2) in the example 1 is changed to 35min, and the medium wave irradiation time is changed to 15 min; adding water in the step (3) to soak at 80 ℃ for 3h, and immediately performing ultrasonic treatment for 12 min; the other steps are the same as in example 1.
Example 7 Epimedium grains and preparation thereof
The formula is as follows: same as in example 1.
The preparation method comprises the following steps: the ultraviolet irradiation vacuum drying operation is changed into hot air circulation drying operation; the other steps and methods were the same as in example 1.
Comparative example 1 Epimedium grains and process for producing the same
The formula is as follows: same as in example 1.
The preparation method comprises the following steps: drying all the medicinal materials in the formula respectively, slicing, mixing the slices, decocting, concentrating the liquid medicine to obtain medicinal material clear paste, and then performing one-step granulation to obtain the Chinese medicinal composition.
Comparative example 2 epimedium and sichuan granules and preparation method thereof
The formula is as follows: same as in example 1.
The preparation method comprises the following steps: is a preparation method disclosed in Chinese patent CN 1113802A.
Comparative example 3
The formula is as follows: same as in example 1.
The preparation method comprises the following steps: pulverizing all the medicinal materials in the formula, sieving with 100 mesh sieve, mixing, adding appropriate amount of sweetener (Mel), and making into granule.
Comparative example 4
The formula is as follows: same as in example 1.
The preparation method comprises the following steps: the difference from example 1 is that the number of the meshes in step (1) was changed to 100 meshes from 200 meshes.
Comparative example 5
The formula is as follows: same as in example 1.
The preparation method comprises the following steps: the difference from example 1 is that the ultraviolet irradiation time in step (2) was shortened to 10min and 5min for 25 mm and 15min, respectively.
Comparative example 6
The formula is as follows: same as in example 1.
The preparation method comprises the following steps: the difference from example 1 is that the ultraviolet irradiation time in step (2) was prolonged and 25 mm and 15min were changed to 45min and 30min, respectively.
Detailed description of the preferred embodiments
The invention adopts 500 cases of patients with acute and chronic bacterial prostatitis randomly selected, which are divided into a control group (comparative examples 1-6) and an experimental group (examples 1-3 and 7), wherein each 50 cases comprises: the experimental group comprises 20 acute patients and 30 chronic patients; the control group had 18 acute patients and 32 chronic patients. The systematic clinical treatment observation of the prostate patients meets the selection standard, and no withdrawal and rejection cases exist. The age of the patients is 40-65 years, and the drug in the comparative example (comparative examples 1-6) is adopted in the control group for routine treatment; the experimental groups were treated with the drug of the present invention (examples 1-3 and 7) for 1-3 treatment courses. The bacterial prostatitis is cured by obviously reducing bacteria under microscopic examination and curing the bacterial prostatitis by eliminating symptoms. The nonbacterial prostatitis is cured by obviously relieving symptoms and eliminating symptoms for 8 months without relapse.
The taking method comprises the following steps: the Chinese patent medicine is taken by 4-6 g once and three times a day. Twenty-two days is a course of treatment. Generally, the medicine is taken for 1-3 courses of treatment; the treatment results are shown in tables 1-3.
Table 1: treatment results of patients with acute and chronic bacterial prostatitis
The data in the table show that the Chinese herbal medicine granules prepared by the formula for treating prostatitis and the preparation method provided by the invention can well cure prostatitis, the total cure rate can reach 84%, the total effective rate can reach 98%, the treatment effect of the Chinese herbal medicine granules prepared in examples 2 and 3 is obviously poorer than that of example 1, but the cure rate and the effective rate are better than that of a proportion; example 7 the ultraviolet irradiation vacuum drying operation is changed to the hot air circulation drying operation on the basis of example 1, and presumably, the effective components of the medicine are not well released, so that the medicine effect is reduced, so that the cure rate and the effective rate are reduced to a certain extent, and the total cure rate can only reach about 60%; the preparation method of the comparative examples 1 and 3 is a conventional preparation method in the field, so that the effective components of the Chinese herbal medicines can not be well released, and the cure rate and the efficiency are not high.
The following table shows the relationship between disease species and curative effect, wherein the treatment course of acute bacterial prostatitis is 1 treatment course, the treatment course of chronic bacterial prostatitis is 3 treatment courses, and the specific data are shown in the following table 2.
Table 2: relationship between disease species and treatment course
The data in the table show that the Chinese herbal medicine particles for treating prostatitis have good treatment effect on acute and chronic bacterial prostates, wherein the cure rate (85%) on the acute bacterial prostates is higher than the cure rate (66.7%) on the chronic bacterial prostates, but the total treatment effect of the Chinese herbal medicine particles provided by the invention is higher than that in the comparative examples, namely the medicine has better treatment effect on the acute bacterial prostates, and the total effective rate can reach 95%, so that the traditional Chinese medicine prepared by the invention is more suitable for relieving and treating acute bacterial prostatitis/hypertrophy, but has good treatment effect on the chronic bacterial prostatitis/hypertrophy.
TABLE 3 treatment results for non-bacterial prostate
The data in the table show that the medicine prepared by the invention has good curative effect on nonbacterial prostatitis, the total effective rate is far higher than that of the medicine in the comparative example, and the data comparison shows that the extraction method combining irradiation-drying-ultrasound-decoction can completely extract the effective components in the medicinal materials, so that the higher utilization rate and extraction rate of the medicinal materials are ensured, the medicine effect is fully exerted, and the medicine has good effect on treating various prostatitis/hypertrophy.

Claims (6)

1. The epimedium-radix-notoginseng-rhizoma traditional Chinese medicine granules are characterized in that: the traditional Chinese medicine granules comprise the following raw materials in parts by weight: 800g of epimedium 600-containing material, 180g of ground beetle 120-containing material, 180g of ginseng 120-containing material, 800g of plantain seed 400-containing material, 500g of peach kernel 250-containing material, 40-80g of pseudo-ginseng, 80-150g of radix curcumae, 600g of fenugreek 400-containing material, 80-200g of common vladimiria root, 700g of clematis stem 400-containing material, 15-40g of amber, 15-40g of centipede, 30-70g of spora lygodii, 500g of phellodendron 300-containing material and 700g of medicinal cyathula root 300-containing material;
the preparation method comprises the following steps:
(1) selecting, washing, cutting and drying ginseng, pseudo-ginseng, radix curcumae, radix aucklandiae and amber in the formula, preparing the dried medicinal materials into traditional Chinese medicine decoction pieces, carrying out superfine grinding and sieving on the prepared traditional Chinese medicine decoction pieces to respectively obtain corresponding medicinal material powder, and sterilizing for later use;
(2) sterilizing the ginseng, pseudo-ginseng, turmeric root-tuber, common vladimiria root and amber powder obtained in the step (1) respectively for later use;
(3) selecting, washing, cutting and drying ten medicinal materials except the ginseng, the pseudo-ginseng, the radix curcumae, the common vladimiria root and the amber powder in the formula, and sterilizing the dried medicinal materials to prepare traditional Chinese medicine decoction pieces;
(4) soaking the Chinese medicinal decoction pieces obtained in the step (3) in water, decocting for two times, removing residues, mixing the decoctions, concentrating to obtain fluid extract with relative density of about 1.10 at 70 deg.C, and collecting the extract to obtain the final product named as YANHUNSAICHUAN granule fluid extract;
(5) mixing the herba Epimedii Sanchuan granule fluid extract obtained in step (4) and the sterilized powders of Ginseng radix, Notoginseng radix, radix Curcumae, radix aucklandiae and Succinum obtained in step (2) with steviosin, making into base material, and granulating and grading by one-step method;
the drying in the step (1) and the step (3) is vacuum drying under the condition of alternately irradiating medium-wavelength ultraviolet rays and long-wavelength ultraviolet rays;
wherein the vacuum drying temperature is room temperature, the drying is carried out for 12-24h, and the superfine grinding is carried out and then the powder is sieved by a 200-mesh sieve; the ultraviolet radiation is 320-400 nm long wave, the radiation is 10-40min and 275-320nm medium wave, and the radiation is performed for 2-3 times alternately for 8-20 min.
2. The traditional Chinese medicine granule as claimed in claim 1, wherein: the traditional Chinese medicine granules comprise the following raw materials in parts by weight: 700g of epimedium 650-charge, 150g of ground beetle 130-charge, 150g of ginseng 130-charge, 600g of plantain seed 500-charge, 400g of peach kernel 300-charge, 50-70g of pseudo-ginseng, 140g of curcuma aromatica 120-charge, 550g of fenugreek seed 450-charge, 150g of common vladimiria root 120-charge, 600g of clematis stem 450-charge, 20-30g of amber, 20-30g of centipede, 50-60g of lygodium japonicum, 450g of phellodendron amurense 400-charge and 600g of medicinal cyathula root 400-charge.
3. The traditional Chinese medicine granule as claimed in claim 2, wherein: the traditional Chinese medicine granules comprise the following raw materials in parts by weight: 700g of epimedium herb, 150g of ground beeltle, 150g of ginseng, 600g of plantain seed, 400g of peach seed, 70g of pseudo-ginseng, 140g of turmeric root-tuber, 550g of fenugreek, 150g of common vladimiria root, 600g of clematis stem, 30g of amber, 30g of centipede, 60g of lygodium japonicum, 450g of amur corktree bark and 600g of medicinal cyathula root.
4. The traditional Chinese medicine granule as claimed in claim 2, wherein: the traditional Chinese medicine granules comprise the following raw materials in parts by weight: 667g of epimedium herb, 133g of ground beeltle, 134g of ginseng, 583g of plantain seed, 334g of peach seed, 58g of pseudo-ginseng, 133g of turmeric root-tuber, 500g of fenugreek, 133g of common vladimiria root, 500g of clematis stem, 25g of amber, 25g of centipede, 58g of lygodium japonicum, 417g of amur corktree bark and 500g of medicinal cyathula root.
5. The traditional Chinese medicine granule as claimed in claim 1, wherein: the preparation method further comprises the following steps: the sterilization in steps (1) - (3) is carried out in a horizontal rectangular pressure steam sterilizer, the thickness of a spreading plate is 3-5cm, the steam pressure is 0.15Mpa, the sterilization is carried out for 30min at 115 ℃, and then the sterilization is carried out for 10-15 min.
6. The traditional Chinese medicine granule as claimed in claim 1, wherein: the preparation method further comprises the following steps: and (4) controlling the soaking temperature in the step (4) to be normal temperature, and controlling the soaking time to be 0.5-1 h.
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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1113802A (en) * 1994-05-27 1995-12-27 四川省遂宁市医药研究所 Powder for curing prostatosis
CN103223052A (en) * 2013-04-27 2013-07-31 陈晖� Traditional Chinese medicine used for treating prostatitis
CN105853571A (en) * 2016-06-19 2016-08-17 练燕华 Traditional Chinese medicine for treating prostatic hyperplasia

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1113802A (en) * 1994-05-27 1995-12-27 四川省遂宁市医药研究所 Powder for curing prostatosis
CN103223052A (en) * 2013-04-27 2013-07-31 陈晖� Traditional Chinese medicine used for treating prostatitis
CN105853571A (en) * 2016-06-19 2016-08-17 练燕华 Traditional Chinese medicine for treating prostatic hyperplasia

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