CN107789580A - 一种治疗肿瘤的药物及其制备方法 - Google Patents

一种治疗肿瘤的药物及其制备方法 Download PDF

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CN107789580A
CN107789580A CN201711154646.5A CN201711154646A CN107789580A CN 107789580 A CN107789580 A CN 107789580A CN 201711154646 A CN201711154646 A CN 201711154646A CN 107789580 A CN107789580 A CN 107789580A
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冯莅雯
梁立丰
王万莉
聂晶
姜若钰
朱琳子
张卿颜
刘坤鹏
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Zhengzhou University
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Abstract

本发明公开了一种治疗肿瘤的药物，由以下重量份的组分制备而成：硒麦芽粉15‑25份、辣木籽10‑15份、茯苓10‑15份、仙甘藤8‑14份、石斛12‑18份、乌梅15‑20份、焦山楂2‑8份、虎杖5‑15份、三七10‑15份、山栀茶10‑15份、蛇麻草7‑13份、鱼腥草5‑10份、雪莲花10‑20份、半枝莲7‑17份、黑枸杞5‑10份、甘草5‑10份、黄芪10‑20份、姜黄片6‑9份。本发明具有解毒散结、活血祛瘀、益气养阴，杀伤癌细胞、抑制癌细胞生长、控制病情发展、提高免疫功能的作用。该药大多采用天然成分、服用安全，无明显副作用，适合患者长期使用。

Description

一种治疗肿瘤的药物及其制备方法
技术领域
本发明涉及中药制剂领域，具体涉及一种治疗肿瘤的药物及其制备方法。
背景技术
肿瘤是机体在各种致癌因素作用下，局部组织的某一个细胞在基因水平上失去对其生长的正常调控，导致其克隆性异常增生而形成的新生物，肿瘤通常分为良性肿瘤和恶性肿瘤。恶性肿瘤会破坏组织、器官的结构和功能，是迄今为止严重威胁人类健康的常见病和多发病之一，寻找有效的抗肿瘤药物与方法，彻底攻克恶性肿瘤是世界医学界的重要研究课题。
中医认为肿瘤是全身性疾病，正虚血淤，余毒未清为其病机特点，肿瘤转移的根本原因在于正气亏虚，邪毒内蕴。无论手术还是化疗治疗，虽达到了有效的减瘤去邪目的，但未从根本上解除患者脏腑、阴阳、气血功能的失调，依据中医治疗肿瘤要讲究辨证论治和整体治疗，将放疗、化疗纳入辩证用药范畴，形成西医攻邪，中医扶正的格局，采用中西医结合的方法进行肿瘤治疗往往能取得较好的效果，中药对肿瘤患者的辅助治疗作用也越来越得到认可。
目前，用于治疗肿瘤的药物很多，但是都不同程度存在着副作用大的缺陷，严重影响患者的治疗和康复。
发明内容
本发明的目的在于提供了一种治疗肿瘤的药物及其制备方法，该药物具有解毒散结、活血祛瘀、益气养阴，杀伤癌细胞、抑制癌细胞生长、控制病情发展、提高免疫功能的作用，且该药均采用天然成分、服用安全，无明显副作用，适合患者长期使用。
为实现上述目的，本发明采取的技术方案为：
一种治疗肿瘤的药物，由以下重量份的组分制备而成：
硒麦芽粉15-25份、辣木籽10-15份、茯苓10-15份、仙甘藤8-14份、石斛12-18份、乌梅15-20份、焦山楂2-8份、虎杖5-15份、三七10-15份、山栀茶10-15份、蛇麻草7-13份、鱼腥草5-10份、雪莲花10-20份、半枝莲7-17份、黑枸杞5-10份、甘草5-10份、黄芪10-20份、姜黄片6-9份。
优选地，由以下重量份的组分制备而成：
硒麦芽粉15份、辣木籽10份、茯苓10份、仙甘藤8份、石斛12份、乌梅15份、焦山楂2份、虎杖5份、三七10份、山栀茶10份、蛇麻草7份、鱼腥草5份、雪莲花10份、半枝莲7份、黑枸杞5份、甘草5份、黄芪10份、姜黄片6份。
优选地，由以下重量份的组分制备而成：
硒麦芽粉25份、辣木籽15份、茯苓15份、仙甘藤14份、石斛18份、乌梅20份、焦山楂8份、虎杖15份、三15份、山栀茶15份、蛇麻草13份、鱼腥草10份、雪莲花20份、半枝莲17份、黑枸杞10份、甘草10份、黄芪20份、姜黄片9份。
优选地，由以下重量份的组分制备而成：
硒麦芽粉20份、辣木籽12.5份、茯苓12.5份、仙甘藤11份、石斛15份、乌梅17.5份、焦山楂5份、虎杖10份、三七12.5份、山栀茶12.5份、蛇麻草10份、鱼腥草7.5份、雪莲花15份、半枝莲12份、黑枸杞7.5份、甘草7.5份、黄芪15份、姜黄片7.5份。
本发明还提供了上述一种治疗肿瘤的药物的制备方法，包括如下步骤；
S1、按上述的配方称取各组分；
S2、将称取的辣木籽、仙甘藤、石斛、山栀茶、蛇麻草、鱼腥草、甘草、黑枸杞和黄芪置于闪式提取器加入6-8倍体积的90％甲醇或乙醇溶液，处理1-3分钟，固液分离后，回收甲醇或乙醇溶液，浓缩，使得提取物呈稠膏状，再用水饱和正丁醇对提取物萃取3次，回收溶剂后，采用钛棒过滤器浓缩，得浓缩液A；
S3、将乌梅去壳后，与称取的茯苓、焦山楂、虎杖、三七、雪莲花、半枝莲和姜黄片置于汽爆罐内，先通入氮气至汽爆罐内压力为0.6-1.4MPa，爆破处理8-25min；然后迅速通入蒸汽至汽爆罐内压力为1.4-1.8MPa，蒸汽爆破处理0.5-2.5min后，采用钛棒过滤器室温浓缩至相对密度1.10-1.20，喷雾干燥浓缩液，得粉体；
S4、向粉体中加入5-9倍水，按粉体重量的3-5％的比例加入由纤维素酶：中性蛋白酶按质量比3∶1混合所得的复合酶，25-35℃下酶解1-2h，过滤，得酶解液；
S5、将所得的酶解液与浓缩液混合搅拌均匀后，喷雾干燥，即得。
本发明具有以下有益效果：
采用天然成分通过优化配比后配置而成，具有解毒散结、活血祛瘀、益气养阴，杀伤癌细胞、抑制癌细胞生长、控制病情发展、提高免疫功能的作用，服用安全，无明显副作用，适合患者长期使用。
具体实施方式
为了使本发明的目的及优点更加清楚明白，以下结合实施例对本发明进行进一步详细说明。应当理解，此处所描述的具体实施例仅仅用以解释本发明，并不用于限定本发明。
实施例1
一种治疗肿瘤的药物，由以下重量份的组分制备而成：
硒麦芽粉15份、辣木籽10份、茯苓10份、仙甘藤8份、石斛12份、乌梅15份、焦山楂2份、虎杖5份、三七10份、山栀茶10份、蛇麻草7份、鱼腥草5份、雪莲花10份、半枝莲7份、黑枸杞5份、甘草5份、黄芪10份、姜黄片6份。
实施例2
一种治疗肿瘤的药物，由以下重量份的组分制备而成：
硒麦芽粉25份、辣木籽15份、茯苓15份、仙甘藤14份、石斛18份、乌梅20份、焦山楂8份、虎杖15份、三15份、山栀茶15份、蛇麻草13份、鱼腥草10份、雪莲花20份、半枝莲17份、黑枸杞10份、甘草10份、黄芪20份、姜黄片9份。
实施例3
一种治疗肿瘤的药物，由以下重量份的组分制备而成：
硒麦芽粉20份、辣木籽12.5份、茯苓12.5份、仙甘藤11份、石斛15份、乌梅17.5份、焦山楂5份、虎杖10份、三七12.5份、山栀茶12.5份、蛇麻草10份、鱼腥草7.5份、雪莲花15份、半枝莲12份、黑枸杞7.5份、甘草7.5份、黄芪15份、姜黄片7.5份。
本发明还提供了上述一种治疗肿瘤的药物的制备方法，包括如下步骤；
S1、按实施例1-实施例3所述的配方称取各组分；
S2、将称取的辣木籽、仙甘藤、石斛、山栀茶、蛇麻草、鱼腥草、甘草、黑枸杞和黄芪置于闪式提取器加入6-8倍体积的90％甲醇或乙醇溶液，处理1-3分钟，固液分离后，回收甲醇或乙醇溶液，浓缩，使得提取物呈稠膏状，再用水饱和正丁醇对提取物萃取3次，回收溶剂后，采用钛棒过滤器浓缩，得浓缩液A；
S3、将乌梅去壳后，与称取的茯苓、焦山楂、虎杖、三七、雪莲花、半枝莲和姜黄片置于汽爆罐内，先通入氮气至汽爆罐内压力为0.6-1.4MPa，爆破处理8-25min；然后迅速通入蒸汽至汽爆罐内压力为1.4-1.8MPa，蒸汽爆破处理0.5-2.5min后，采用钛棒过滤器室温浓缩至相对密度1.10-1.20，喷雾干燥浓缩液，得粉体；
S4、向粉体中加入5-9倍水，按粉体重量的3-5％的比例加入由纤维素酶：中性蛋白酶按质量比3∶1混合所得的复合酶，25-35℃下酶解1-2h，过滤，得酶解液；
S5、将所得的酶解液与浓缩液混合搅拌均匀后，喷雾干燥，即得。
经大量的治疗案例实践，本实施例所得的治肿瘤制剂具有解毒散结、活血祛瘀、益气养阴，杀伤癌细胞、抑制癌细胞生长、控制病情发展、提高免疫功能的作用，且未见病人有不良反应，适合患者长期使用。
以上所述仅是本发明的优选实施方式，应当指出，对于本技术领域的普通技术人员来说，在不脱离本发明原理的前提下，还可以作出若干改进和润饰，这些改进和润饰也应视为本发明的保护范围。

Claims (5)

1.一种治疗肿瘤的药物，其特征在于，由以下重量份的组分制备而成：
硒麦芽粉15-25份、辣木籽10-15份、茯苓10-15份、仙甘藤8-14份、石斛12-18份、乌梅15-20份、焦山楂2-8份、虎杖5-15份、三七10-15份、山栀茶10-15份、蛇麻草7-13份、鱼腥草5-10份、雪莲花10-20份、半枝莲7-17份、黑枸杞5-10份、甘草5-10份、黄芪10-20份、姜黄片6-9份。
2.如权利要求1所述的一种治疗肿瘤的药物，其特征在于，由以下重量份的组分制备而成：
硒麦芽粉15份、辣木籽10份、茯苓10份、仙甘藤8份、石斛12份、乌梅15份、焦山楂2份、虎杖5份、三七10份、山栀茶10份、蛇麻草7份、鱼腥草5份、雪莲花10份、半枝莲7份、黑枸杞5份、甘草5份、黄芪10份、姜黄片6份。
3.如权利要求1所述的一种治疗肿瘤的药物，其特征在于，由以下重量份的组分制备而成：
硒麦芽粉25份、辣木籽15份、茯苓15份、仙甘藤14份、石斛18份、乌梅20份、焦山楂8份、虎杖15份、三15份、山栀茶15份、蛇麻草13份、鱼腥草10份、雪莲花20份、半枝莲17份、黑枸杞10份、甘草10份、黄芪20份、姜黄片9份。
4.如权利要求1所述的一种治疗肿瘤的药物，其特征在于，由以下重量份的组分制备而成：
硒麦芽粉20份、辣木籽12.5份、茯苓12.5份、仙甘藤11份、石斛15份、乌梅17.5份、焦山楂5份、虎杖10份、三七12.5份、山栀茶12.5份、蛇麻草10份、鱼腥草7.5份、雪莲花15份、半枝莲12份、黑枸杞7.5份、甘草7.5份、黄芪15份、姜黄片7.5份。
5.一种治疗肿瘤的药物的制备方法，其特征在于，包括如下步骤；
S1、按权利要求1-4任一项所述的配方称取各组分；
S2、将称取的辣木籽、仙甘藤、石斛、山栀茶、蛇麻草、鱼腥草、甘草、黑枸杞和黄芪置于闪式提取器加入6-8倍体积的90％甲醇或乙醇溶液，处理1-3分钟，固液分离后，回收甲醇或乙醇溶液，浓缩，使得提取物呈稠膏状，再用水饱和正丁醇对提取物萃取3次，回收溶剂后，采用钛棒过滤器浓缩，得浓缩液A；
S3、将乌梅去壳后，与称取的茯苓、焦山楂、虎杖、三七、雪莲花、半枝莲和姜黄片置于汽爆罐内，先通入氮气至汽爆罐内压力为0.6-1.4MPa，爆破处理8-25min；然后迅速通入蒸汽至汽爆罐内压力为1.4-1.8MPa，蒸汽爆破处理0.5-2.5min后，采用钛棒过滤器室温浓缩至相对密度1.10-1.20，喷雾干燥浓缩液，得粉体；
S4、向粉体中加入5-9倍水，按粉体重量的3-5％的比例加入由纤维素酶：中性蛋白酶按质量比3∶1混合所得的复合酶，25-35℃下酶解1-2h，过滤，得酶解液；
S5、将所得的酶解液与浓缩液混合搅拌均匀后，喷雾干燥，即得。
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