CN107789453A - A kind of Chinese medicine composition for treating aphtha and preparation method thereof - Google Patents

A kind of Chinese medicine composition for treating aphtha and preparation method thereof Download PDF

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Publication number
CN107789453A
CN107789453A CN201610767182.4A CN201610767182A CN107789453A CN 107789453 A CN107789453 A CN 107789453A CN 201610767182 A CN201610767182 A CN 201610767182A CN 107789453 A CN107789453 A CN 107789453A
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parts
chinese medicine
medicine composition
radix
hours
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宋德成
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Tianjin Pacific Pharmaceutical Co Ltd
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Tianjin Pacific Pharmaceutical Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • A61K36/748Oldenlandia or Hedyotis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/35Caprifoliaceae (Honeysuckle family)
    • A61K36/355Lonicera (honeysuckle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537Salvia (sage)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718Coptis (goldthread)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • A61K36/744Gardenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888Pinellia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

Abstract

The invention provides a kind of Chinese medicine composition for treating aphtha and preparation method thereof.The Chinese medicine composition is composed of the following components in parts by weight:15 25 parts of oldenlandia diffusa;18 20 parts of honeysuckle;15 18 parts of the red sage root;7 10 parts of borneol;58 parts of radix glycyrrhizae;8 10 parts of the coptis;7 10 parts of cape jasmine;9 10 parts of the tuber of pinellia;10 12 parts of Radix Angelicae Sinensis;16 24 parts of the Radix Astragali;1 20 parts of auxiliary material.It is demonstrated experimentally that Chinese medicine composition of the present invention has the effect of promoting aphtha healing.

Description

A kind of Chinese medicine composition for treating aphtha and preparation method thereof
Technical field
The present invention relates to Chinese medicine composition and preparing technical field, more particularly to a kind of Chinese medicine composition for treating aphtha and Its preparation method.
Background technology
The big ulcer point of raw yellow-white such as beans is this mouth disease of principal character on ten weeks mucous membrane of mouth of aphtha.Ulcer With periodicity, recurrent, lip, tongue etc. are apt to occur in, inducement is probably local trauma, stress, hypovitaminosis etc..The traditional Chinese medical science Think that mainly spleen kidney deficiency damage, heat make caused by malicious fire gathers from interior.With the passing of time the course of disease, blood vessels imbalance, causes ulcer not to be cured for a long time.
The Chinese medicine preparation of the marketed treatment aphtha of existing market is mostly smear type, and the effect of oral formulations is also paid no attention to Think.Therefore finding a kind of effect, well wieldy Chinese medicine composition is particularly important again.
The content of the invention
The technical problem to be solved in the present invention be in the prior art treat aphtha Chinese medicine composition effect difference and not A kind of the problem of beneficial to using, there is provided Chinese medicine composition for treating aphtha and preparation method thereof.
In order to solve the above-mentioned technical problem, technical scheme provided by the invention is:
A kind of Chinese medicine composition for treating aphtha, the Chinese medicine composition are composed of the following components in parts by weight:
Oldenlandia diffusa 15-25 parts;Honeysuckle 18-20 parts;Red sage root 15-18 parts;Borneol 7-10 parts;Radix glycyrrhizae 5-8 parts;The coptis 8-10 parts;Cape jasmine 7-10 parts;Tuber of pinellia 9-10 parts;Radix Angelicae Sinensis 10-12 parts;Radix Astragali 16-24 parts;Auxiliary material 1-20 parts.
In above-mentioned composition, using oldenlandia diffusa, honeysuckle, the red sage root and the Radix Astragali as monarch drug in a prescription, ministerial drug borneol, Huang are accompanied by Company, cape jasmine, the tuber of pinellia, Radix Angelicae Sinensis, help with radix glycyrrhizae, polishing promoting blood circulation, clearing heat and detoxicating, the effect of warming the upper and clearing away heat in the lower can be reached.
Wherein oldenlandia diffusa bitter, light, it is cold in nature.Primary efficacy is clearing heat and detoxicating, medicinal powder for relieving pain knot, promoting urination and removing dampness.It is outstanding kind Treat all kinds inflammation.In clinical practice, if finding, oldenlandia diffusa compatibility is proper, can treat a variety of diseases.Herb contains Asperuloside, asperuloside acid, acetic acid being removed, base asperuloside is sour, all square rafter glucoside, Chinese Fevervine Herb time glucoside, Chinese Fevervine Herb time glucoside methyl esters, 6-O- p- hydroxyl cinnamyl Chinese Fevervine Herb time glucoside methyl esters, 6-O- p- methoxyl group cinnamyl Chinese Fevervine Herb time glucoside methyl esters, 6-O- asafoetide acyls Chinese Fevervine Herb time glucoside methyl esters, 2- methyl -3- hydroxy-anthraquiones, 2- methyl -3- methoxy anthraquinones, 2- methyl -3- hydroxyl -4- methoxyl group anthracenes Quinone etc., and ursolic acid, cupreol, hentriacontane, stigmasterol, oleanolic acid, cupreol-β-glycoside, p- tonka-bean Acid etc..
Honeysuckle is described as clearing heat and detoxicating good medicine from ancient times.The sweet cold air fragrance of its property, clear heat with drugs of sweet flavour and cold nature is without injuring one's stomach, and fragrance is thoroughly Up to again can eliminating evil.Honeysuckle can dispelling wind-heat, also kind removing summer-heat blood poison, for various febrile diseases, such as body heat, dermexanthesis, send out spot, heat The diseases such as carbuncle carbuncle, abscess of throat, equal significant effect.Honeysuckle is cold in nature, sweet, enters lung, the heart, stomach, has clearing heat and detoxicating, anti- Scorching, qi-restoratives treats the effect of wind, cures mainly disease under turgor, warm disease heating, the disease such as heat toxin large carbuncle and tumour.It is for dizziness, mouth It is dry to make thirsty, sweating and boring, enteritis, bacillary dysentery, measles, pneumonia, encephalitis, epidemic meningitis, acute mastitis, septicemia, appendicitis, skin sense The illnesss such as dye, ulcer boils, erysipelas, parotitis, suppurative tonsillitis have certain curative effect.
The red sage root has promoting blood circulation, inducing meastruation to relieve menalgia, relieving restlessness that clears away heart-fire, the effect of cool blood to disappear carbuncle.For chest impediment and cardialgia, the gastral cavity abdomen side of body Bitterly, lump in the abdomen lump in the abdomen is gathered, hot numbness pain, dysphoria and insomnia, irregular menstruation, dysmenorrhoea Amenorrhea, sore swell and ache curative.
The Radix Astragali has enhancing body's immunity, liver protection, diuresis, anti-aging, resisting stress, decompression and wide antibacterial to make With.Jishengshenqiwan albuminuria can be eliminated, strengthens myocardial contractive power, adjusts blood-sugar content.The Radix Astragali can not only coronary artery dilator, Improve myocardial blood supply, improve immunologic function, and be capable of the process of delaying cell aging.
The compatibility and ratio of above four traditional Chinese medicine thing are the keys of pharmaceutical composition of the present invention.Preferably, the Chinese medicine group Compound is composed of the following components in parts by weight:
20 parts of oldenlandia diffusa;20 parts of honeysuckle;18 parts of the red sage root;8 parts of borneol;6 parts of radix glycyrrhizae;8 parts of the coptis;10 parts of cape jasmine; 10 parts of the tuber of pinellia;12 parts of Radix Angelicae Sinensis;20 parts of the Radix Astragali;15 parts of auxiliary material.
The preparation of Chinese medicine composition of the present invention is freeze dried powder, therefore in order to improve the mouthfeel of medicine, preferably, at this In one embodiment of invention, the Chinese medicine composition also includes sweetener and/or flavouring agent.
In the present invention, the effect of selection of auxiliary material is final to preparation also functions to important function.Preferably, the auxiliary material For one kind in mannitol, phosphate, glycine, lysine, albumin, DLPC, cholesterol or It is several.
Present invention also offers a kind of preparation method of above-mentioned Chinese medicine composition, comprise the following steps:
Step 1) divides oldenlandia diffusa, honeysuckle, the red sage root, borneol, radix glycyrrhizae, the coptis, cape jasmine, the tuber of pinellia, Radix Angelicae Sinensis and the Radix Astragali Not Li Yong alcohol extracting method extract 3~5 hours, obtain respective extract;
Step 2) mixes extract made from step 1 with auxiliary material, dries, drug powder is obtained after smashing;
The drug powder that step 3) obtains step 3 is placed in household freezer, is freezed at -40 DEG C 1.5~2 hours, at this At a temperature of crush, dry, obtain freeze-dried powder;
The freeze-dried powder that step 4) obtains step 3) loads packaging, obtains the Chinese medicine composition.
Preferably, the condition of the step 1) alcohol extracting method is:The oldenlandia diffusa, honeysuckle, the red sage root, the Radix Astragali are added 80% ethanol for entering 5 times of volumes extracts 5 hours;The borneol, radix glycyrrhizae, the coptis, cape jasmine, the tuber of pinellia, Radix Angelicae Sinensis are added into 10 times of volumes 65% ethanol extract 8 hours.
It is highly preferred that step 1) is described to be extracted as refluxing extraction, number is 3 times.
Preferably, the step 3) time freezed is 1.5 hours.
Preferably, the grain diameter of the step 3) freeze-dried powder is less than 10 microns.
Present invention also offers a kind of application method of above-mentioned Chinese medicine composition, by the powder of the Chinese medicine composition 50 Dissolve and take after mixing it with water in~60 DEG C of solvents.
Beneficial effects of the present invention are:
The present invention is accompanied by ministerial drug borneol, the coptis, cape jasmine, half using oldenlandia diffusa, honeysuckle, the red sage root and the Radix Astragali as monarch drug in a prescription Summer, Radix Angelicae Sinensis, help with radix glycyrrhizae, polishing promoting blood circulation, clearing heat and detoxicating, the effect of warming the upper and clearing away heat in the lower can be reached.
Embodiment
The invention discloses a kind of Chinese medicine composition for treating aphtha and preparation method thereof., those skilled in the art can be with Present disclosure is used for reference, is suitably modified technological parameter realization.It is important to note that all similar replacements and change are to ability It is it will be apparent that they are considered as being included in the present invention for field technique personnel, and related personnel can substantially not take off Content described herein is modified or suitably changed with combining from the basis of present invention, spirit and scope, to realize With using the technology of the present invention.
In the present invention, unless otherwise stated, Science and Technology noun used herein has art technology The implication that personnel are generally understood that.
In order that those skilled in the art more fully understands technical scheme, with reference to specific embodiment pair The present invention is described in further detail.
Embodiment 1:Chinese medicine composition
The Chinese medicine composition is composed of the following components in parts by weight:
20 parts of oldenlandia diffusa;20 parts of honeysuckle;18 parts of the red sage root;8 parts of borneol;6 parts of radix glycyrrhizae;8 parts of the coptis;10 parts of cape jasmine; 10 parts of the tuber of pinellia;12 parts of Radix Angelicae Sinensis;20 parts of the Radix Astragali;15 parts of auxiliary material.
Embodiment 2:Chinese medicine composition
The Chinese medicine composition is composed of the following components in parts by weight:
25 parts of oldenlandia diffusa;20 parts of honeysuckle;18 parts of the red sage root;10 parts of borneol;8 parts of radix glycyrrhizae;10 parts of the coptis;Cape jasmine 10 Part;10 parts of the tuber of pinellia;12 parts of Radix Angelicae Sinensis;24 parts of the Radix Astragali;20 parts of auxiliary material.
Embodiment 3:Chinese medicine composition
The Chinese medicine composition is composed of the following components in parts by weight:
15 parts of oldenlandia diffusa;18 parts of honeysuckle;15 parts of the red sage root;7 parts of borneol;5 parts of radix glycyrrhizae;8 parts of the coptis;7 parts of cape jasmine;Half 9 parts of summer;10 parts of Radix Angelicae Sinensis;16 parts of the Radix Astragali;1 part of auxiliary material.
Embodiment 4:Prepare embodiment
Take 20 parts of oldenlandia diffusa;20 parts of honeysuckle;18 parts of the red sage root;20 parts of the Radix Astragali, is cleaned respectively, is separately added into 5 times of bodies In 80% ethanol of product, refluxing extraction 3 times, 5 hours every time, respective extract is obtained.
Take 8 parts of borneol;6 parts of radix glycyrrhizae;8 parts of the coptis;10 parts of cape jasmine;10 parts of the tuber of pinellia;12 parts of Radix Angelicae Sinensis, is cleaned respectively, is added respectively Enter in 10 times of ethanol of volume 65%, refluxing extraction 3 times, 8 hours every time, obtain respective extract.
Said extracted thing is mixed, 15 parts of auxiliary materials is added, dry, pulverize, obtain drug powder.
Said medicine powder is placed in household freezer, freezes at -40 DEG C 1.5 hours, crushes at such a temperature, is dried, Freeze-dried powder is obtained, the grain diameter of the freeze-dried powder is 10 microns.
Above-mentioned freeze-dried powder is loaded and packed, obtains the Chinese medicine composition.
Embodiment 5:Prepare embodiment
Take 25 parts of oldenlandia diffusa;20 parts of honeysuckle;18 parts of the red sage root;24 parts of the Radix Astragali, is cleaned respectively, is separately added into 5 times of bodies In 80% ethanol of product, refluxing extraction 3 times, 5 hours every time, respective extract is obtained.
Take 10 parts of borneol;8 parts of radix glycyrrhizae;10 parts of the coptis;10 parts of cape jasmine;10 parts of the tuber of pinellia;12 parts of Radix Angelicae Sinensis, is cleaned respectively, respectively Add in 10 times of ethanol of volume 65%, refluxing extraction 3 times, 8 hours every time, obtain respective extract.
Said extracted thing is mixed, 20 parts of auxiliary materials is added, dry, pulverize, obtain drug powder.
Said medicine powder is placed in household freezer, freezes at -40 DEG C 2 hours, crushes at such a temperature, dries, obtains To freeze-dried powder, the grain diameter of the freeze-dried powder is 8 microns.
Above-mentioned freeze-dried powder is loaded and packed, obtains the Chinese medicine composition.
Embodiment 6:Prepare embodiment
Take 15 parts of oldenlandia diffusa;18 parts of honeysuckle;15 parts of the red sage root;16 parts of the Radix Astragali, is cleaned respectively, is separately added into 5 times of bodies In 80% ethanol of product, refluxing extraction 3 times, 5 hours every time, respective extract is obtained.
Take 7 parts of borneol;5 parts of radix glycyrrhizae;8 parts of the coptis;7 parts of cape jasmine;9 parts of the tuber of pinellia;10 parts of Radix Angelicae Sinensis, cleans, is separately added into respectively In 10 times of ethanol of volume 65%, refluxing extraction 3 times, 8 hours every time, respective extract is obtained.
Said extracted thing is mixed, 1 part of auxiliary material is added, dry, pulverize, obtain drug powder.
Said medicine powder is placed in household freezer, freezes at -40 DEG C 2 hours, crushes at such a temperature, dries, obtains To freeze-dried powder, the grain diameter of the freeze-dried powder is 8 microns.
Above-mentioned freeze-dried powder is loaded and packed, obtains the Chinese medicine composition.
Effect experiment of the Chinese medicine composition of embodiment 7 to rabbit aphtha model
Ripe healthy rabbits are taken, rabbit oral mucosa surface is perpendicularly fixed at the glass tube of internal diameter a 0.6cm, long 3cm, After injected slurry volume fraction is 30% into pipe glacial acetic acid 0.2mL, 30s glacial acetic acid is dipped in out with cotton swab.After 24h, measure mucous membrane is burst Ulcer area and observation inflammatory congestion situation.
Take (± 0.1cm similar in measurement aphtha area2) rabbit, random packet, blank group and various dose are set respectively Administration group.Administration group is according to 1g/kg, 5g/kg, 8g/kg dosage successive administration 7 days, and once a day, the medicine is embodiment 1 With 4 in the composition for preparing, blank group gives auxiliary material, continuous 7 days, once a day.Experiment measures animal aphtha area after terminating, As a result it is as shown in table 1.
The Chinese medicine composition effect test result of the present invention of table 1
As can be seen from the above results, the present invention has the effect of promoting aphtha healing.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should It is considered as protection scope of the present invention.

Claims (10)

1. a kind of Chinese medicine composition for treating aphtha, it is characterised in that the Chinese medicine composition is by following parts by weight into packet Into:
Oldenlandia diffusa 15-25 parts;Honeysuckle 18-20 parts;Red sage root 15-18 parts;Borneol 7-10 parts;Radix glycyrrhizae 5-8 parts;Coptis 8-10 Part;Cape jasmine 7-10 parts;Tuber of pinellia 9-10 parts;Radix Angelicae Sinensis 10-12 parts;Radix Astragali 16-24 parts;Auxiliary material 1-20 parts.
2. Chinese medicine composition according to claim 1, it is characterised in that the Chinese medicine composition by following parts by weight into It is grouped into:
20 parts of oldenlandia diffusa;20 parts of honeysuckle;18 parts of the red sage root;8 parts of borneol;6 parts of radix glycyrrhizae;8 parts of the coptis;10 parts of cape jasmine;The tuber of pinellia 10 parts;12 parts of Radix Angelicae Sinensis;20 parts of the Radix Astragali;15 parts of auxiliary material.
3. Chinese medicine composition according to claim 1, it is characterised in that the Chinese medicine composition also include sweetener and/ Or flavouring agent.
4. Chinese medicine composition according to claim 1, it is characterised in that the auxiliary material is selected from mannitol, phosphate, sweet One or more in propylhomoserin, lysine, albumin, DLPC, cholesterol.
5. the preparation method of a kind of Chinese medicine composition as described in claim 1-4 any one, it is characterised in that including following Step:
Step 1) is sharp respectively by oldenlandia diffusa, honeysuckle, the red sage root, borneol, radix glycyrrhizae, the coptis, cape jasmine, the tuber of pinellia, Radix Angelicae Sinensis and the Radix Astragali Extracted 3~5 hours with alcohol extracting method, obtain respective extract;
Step 2) mixes extract made from step 1 with auxiliary material, dries, drug powder is obtained after smashing;
The drug powder that step 3) obtains step 3 is placed in household freezer, is freezed at -40 DEG C 1.5~2 hours, in the temperature Lower crushing, dry, obtain freeze-dried powder;
The freeze-dried powder that step 4) obtains step 3) loads packaging, obtains the Chinese medicine composition.
6. preparation method according to claim 5, it is characterised in that the condition of the step 1) alcohol extracting method is:By described in 80% ethanol that oldenlandia diffusa, honeysuckle, the red sage root, the Radix Astragali add 5 times of volumes extracts 5 hours;By the borneol, radix glycyrrhizae, Huang Company, cape jasmine, the tuber of pinellia, 65% ethanol of Radix Angelicae Sinensis 10 times of volumes of addition extract 8 hours.
7. preparation method according to claim 6, it is characterised in that step 1) is described to be extracted as refluxing extraction, number 3 It is secondary.
8. preparation method according to claim 5, it is characterised in that the step 3) time freezed is 1.5 hours.
9. preparation method according to claim 5, it is characterised in that the grain diameter of the step 3) freeze-dried powder is 10 Micron is following.
10. a kind of application method of Chinese medicine composition as claimed in claim 1, it is characterised in that by the Chinese medicine composition Powder dissolve and take after mixing it with water in 50~60 DEG C of solvents.
CN201610767182.4A 2016-08-30 2016-08-30 A kind of Chinese medicine composition for treating aphtha and preparation method thereof Pending CN107789453A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000006181A1 (en) * 1998-07-24 2000-02-10 Jinchu Lan A medicament for treating recurrent ulcer of mouth and behcet's syndrome
CN101181547A (en) * 2007-11-29 2008-05-21 唐凯 Chinese medicine for curing halitosis, dry mouth, bitter taste and mouth ulcer
CN104324098A (en) * 2014-11-19 2015-02-04 天津太平洋制药有限公司 Traditional Chinese medicine for treating aphtha

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000006181A1 (en) * 1998-07-24 2000-02-10 Jinchu Lan A medicament for treating recurrent ulcer of mouth and behcet's syndrome
CN101181547A (en) * 2007-11-29 2008-05-21 唐凯 Chinese medicine for curing halitosis, dry mouth, bitter taste and mouth ulcer
CN104324098A (en) * 2014-11-19 2015-02-04 天津太平洋制药有限公司 Traditional Chinese medicine for treating aphtha

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Application publication date: 20180313