CN107744542A - 一种治疗急性阑尾炎的药物及其制备方法 - Google Patents
一种治疗急性阑尾炎的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗急性阑尾炎的药物及其制备方法，其主要是由金银花、蒲公英、牡丹皮、大血藤、大黄、川楝子、赤芍、桃仁按一定重量配比制备而成，本发明药物具有清热解毒，降湿热，清肝火，活血通络，泻热毒，破积滞的功能，用于治疗急性阑尾炎见效快，疗效好，不复发。
Description
技术领域
本发明涉及一种治疗急性阑尾炎的药物及其制备方法，属中药领域。
技术背景
急性阑尾炎是因多种因素而形成的炎性改变，为外科常见病，以青年最为多见，男性多于女性。中医则认为急性阑尾炎与气滞血瘀，湿热蕴结，热毒蕴结有关。由于西医手术费用高，因此人们对有效治疗急性阑尾炎的中药药物存在极大的需求，至今为止，还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证，终于找到了有效治疗急性阑尾炎的药物，从而完成了本发明。
本发明的目的就是提供一种有效治疗急性阑尾炎的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择金银花、蒲公英、牡丹皮、大血藤、大黄、川楝子、赤芍、桃仁、甘草、藿香进行组合制备的，将这些药物组合使得各药物功效产生协同作用，从而能够有效治疗急性阑尾炎。其中，选用金银花是因为其性味甘，寒，入肺、胃经，有清热，解毒的功能，治温病发热，热毒血痢，痈疡，肿毒，瘰疬，痔漏。选用蒲公英是因为其性味苦甘，寒，入肝、胃经，有清热解毒，利尿散结的功能，治急性乳腺炎，淋巴腺炎，瘰疬，疔毒疮肿，急性结膜炎，感冒发热，急性扁桃体炎，急性支气管炎，胃炎，肝炎，胆囊炎，尿路感染。选用牡丹皮是因为其性味辛苦，凉，入心、肝、肾经，有清热，凉血，和血，消瘀的功能，治热入血分，发斑，惊癎，吐、衄、便血，骨蒸劳热，经闭，癥瘕，痈疡，扑损。选用大血藤是因为其性味苦，平，入肝、大肠二经，有败毒消痈，活血通络，祛风杀虫的功能，治急、慢性阑尾炎，风湿痹痛，赤痢，血淋，月经不调，疳积，虫痛，跌扑损伤。选用大黄是因为其性味苦、寒，入胃、大肠、肝径，有泻热毒，破积滞，行瘀血的功能，治实热便秘，谵语发狂，食积痞满，痢疾初起，里急后重，瘀停经闭，癥瘕积聚，时行热疫，暴眼赤痛，吐血，衄血，阳黄，水肿，淋浊，溲赤，痈疡肿毒，疔疮，汤火伤。选用川楝子是因为其性味苦，寒，有毒，入肝、胃、小肠经，有降湿热，清肝火，止痛，杀虫的功能，治热厥心痛，胁痛，疝痛，虫积腹痛。选用赤芍是因为其性味苦，微寒，归肝经，有清热凉血，散瘀止痛的功能，治温毒发狂，吐血衄血，目赤肿痛，肝郁胁痛，经闭痛经，癎瘕腹痛，跌扑损伤，痈肿疮疡。选用桃仁是因为其性味苦甘，平，入心、肝、大肠经，有破血行瘀，润燥滑经的功能，治经闭，癥瘕，热病蓄血，血痹，疟疾，跌打损伤，瘀血肿痛，血燥便秘。选用甘草是因为其性味甘，平，入脾、胃、肺经，有和中缓急，润肺，解毒，调和诸药的功能，炙用，治脾胃虚弱，食少，腹痛便溏，劳倦发热，肺痿咳嗽，心悸，惊癎；生用，治咽喉肿痛，消化性溃疡，痈疽疮疡，解药毒及食物中毒。选用藿香是因为其性味辛，微温，入肺、脾、胃经，有快气，和中，辟秽，祛湿的功能，治感冒暑湿，寒热，头痛，胸脘痞闷，呕吐泄泻，疟疾，痢疾，口臭。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的，各组分的用量在下述重量范围内都具有较好的疗效：
金银花40-60克，蒲公英40-60克，牡丹皮20-30克，大血藤20-30克，大黄20-30克，川楝子10-20克，赤芍15-25克，桃仁10-20克，甘草10-20克，藿香10-20克。
优选为：
金银花50克，蒲公英50克，牡丹皮25克，大血藤25克，大黄25克，川楝子15克，赤芍20克，桃仁15克，甘草15克，藿香15克。
本发明药物的制备方法如下
一、备料
1、金银花：筛去泥沙，拣净杂质；
2、蒲公英：拣去杂质，洗净泥土，切段，晒干；
3、牡丹皮：拣去杂质，除去木心，洗净，润透，切片，晾干；
4、大血藤：用水浸泡，洗净泥屑，润透，切片，晒干；
5、大黄：拣净杂质，大小分档，闷润至内外湿度均匀，切片或切成小块、晒干；
6、川楝子：拣去杂质，洗净，烘干，轧碎或劈成两半；
7、赤芍：取原药材，除去杂质，大小分档，洗净，润透，切薄片，干燥，筛去碎屑；
8、桃仁：除去硬壳杂质，置沸水锅中煮至外皮微皱，捞出，浸入凉水中，搓去种皮，晒干，簸净；
9、甘草：拣去杂质，洗净，用水浸泡至八成透时，捞出，润透切片，晒干；
10、藿香：拣去杂质，除去残根及老茎，先将叶摘下另放，茎用水润透，切段，晒干，然后与叶和匀。
二、制备
1、将炮制后的金银花、蒲公英、牡丹皮、大血藤、大黄、川楝子、赤芍、桃仁、甘草、藿香放入煎药容器内，第一次加水6倍量，浸泡100分钟后，武火煎煮沸腾，再用文火煎煮20分钟，过滤得第一次煎煮液，将第一次煎煮液倒入容器内；
2、将过滤的药渣加4倍量，武火煮沸，再用文火煎煮20分钟，过滤得第二次煎煮液；
3、将两次煎煮液混合搅拌均匀，分为2剂服用。
组方中蒲公英有清热解毒，利尿散结的功能为君药；川楝子降湿热，清肝火；大血藤有败毒消痈，活血通络的功能，二者为臣药，三味药共同发挥清热解毒，利尿散结，降湿热，清肝火，败毒消痈，活血通络的作用，治疗急性阑尾炎效力全面，且以清热解毒，降湿热，清肝火，活血通络为主可治本，大黄有泻热毒，破积滞，行瘀血的功能为佐药，藿香有快气，和中，辟秽，祛湿的功能为使药，与余下诸药是治标。
本发明药物具有清热解毒，降湿热，清肝火，活血通络，泻热毒，破积滞的功能，用于治疗急性阑尾炎，疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果，这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告：
取家兔30只，雌雄兼用，体重2.0—2.5kg，分两组，每组15只，其中一组为超剂量试验组，另一组为正常量试验组。超常量组为20ml/kg，正常量为10ml/kg，给药方式为灌胃法给药，每天两次，连服7天，每天观察给药反应，结果表明二组家兔活动、饮食正常，药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治急性阑尾炎门诊患者共23例。
2、诊断标准
典型症状为腹部压痛，反跳痛，恶心呕吐，发热，腹肌紧张等。
3、治疗方法
选用上述药剂，给患者服用，每次服用1剂，每天2次，7天为一个疗程，连续服用2个疗程。
4、疗效评定标准
显效：急性阑尾炎症状消失，体质恢复正常，痊愈；
好转：患者腹痛，恶心呕吐，发热，腹肌紧张的现象减轻，急性阑尾炎症状明显好转，体质逐步恢复；
无效：达不到好转标准者。
5、治疗结果（见下表）
在上述治疗中，用本发明药物治疗急性阑尾炎患者23例，结果显效20例，显效率为86.95%，好转2例，好转率为8.7%，无效1例，总有效率为95.65%。
Claims (3)
1.一种治疗急性阑尾炎的药物，其特征在于：它是由下列重量范围内的原料药制成：
金银花40-60克，蒲公英40-60克，牡丹皮20-30克，大血藤20-30克，大黄20-30克，川楝子10-20克，赤芍15-25克，桃仁10-20克，甘草10-20克，藿香10-20克。
2.根据权利要求1所述的药物，其中各原料药的用量为：
金银花50克，蒲公英50克，牡丹皮25克，大血藤25克，大黄25克，川楝子15克，赤芍20克，桃仁15克，甘草15克，藿香15克。
3.根据权利要求1或2所述药物的制备方法，它包括下列步骤：
（一）备料
（1）金银花：筛去泥沙，拣净杂质；
（2）蒲公英：拣去杂质，洗净泥土，切段，晒干；
（3）牡丹皮：拣去杂质，除去木心，洗净，润透，切片，晾干；
（4）大血藤：用水浸泡，洗净泥屑，润透，切片，晒干；
（5）大黄：拣净杂质，大小分档，闷润至内外湿度均匀，切片或切成小块、晒干；
（6）川楝子：拣去杂质，洗净，烘干，轧碎或劈成两半；
（7）赤芍：取原药材，除去杂质，大小分档，洗净，润透，切薄片，干燥，筛去碎屑；
（8）桃仁：除去硬壳杂质，置沸水锅中煮至外皮微皱，捞出，浸入凉水中，搓去种皮，晒干，簸净；
（9）甘草：拣去杂质，洗净，用水浸泡至八成透时，捞出，润透切片，晒干；
（10）藿香：拣去杂质，除去残根及老茎，先将叶摘下另放，茎用水润透，切段，晒干，然后与叶和匀；
（二）制备
（1）将炮制后的金银花、蒲公英、牡丹皮、大血藤、大黄、川楝子、赤芍、桃仁、甘草、藿香放入煎药容器内，加水6倍量，浸泡100分钟后，武火煎煮沸腾，再用文火煎煮20分钟，过滤得第一次煎煮液，将第一次煎煮液倒入容器内；
（2）将过滤的药渣加水4倍量，武火煮沸，再用文火煎煮20分钟，过滤得第二次煎煮液；
（3）将两次煎煮液混合搅拌均匀，分为2剂服用。
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