CN107669508B - 一种抗菌湿巾的制备工艺 - Google Patents

一种抗菌湿巾的制备工艺 Download PDF

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CN107669508B
CN107669508B CN201611138062.4A CN201611138062A CN107669508B CN 107669508 B CN107669508 B CN 107669508B CN 201611138062 A CN201611138062 A CN 201611138062A CN 107669508 B CN107669508 B CN 107669508B
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essential oil
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polyhexamethylene guanidine
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李培耀
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Qingdao University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/72Cosmetics or similar toilet preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toilet preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/46Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing sulfur
    • A61K8/463Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4993Derivatives containing from 2 to 10 oxyalkylene groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005Antimicrobial preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/10Washing or bathing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions

Abstract

本发明涉及一种抗菌湿巾的制备工艺,属于化妆品领域。本发明的抗菌湿巾的制备工艺通过以下方法制备而成:(1)按如下重量配比称取原料:聚六亚甲基胍0.1‑0.5%,绿花白千层精油0.2‑0.5%,聚山梨酯‑80 10‑20%,鲸蜡硬脂醇硫酸酯钠3‑10%,丙三醇1‑5%,去离子水65‑80%;(2)将聚山梨酯‑80和鲸蜡硬脂醇硫酸酯钠溶于去离子水中,加入丙三醇,加热至40‑60℃,搅拌均匀,加入聚六亚甲基胍,继续搅拌均匀,降温至室温,加入绿花白千层精油,搅拌均匀,得湿巾液;(3)将水刺无纺布浸入湿巾液中,取出后包装即得。本发明的抗菌湿巾采用聚六亚甲基胍和绿花白千层精油配伍作为抑菌剂,将有机合成杀菌剂和植物提取杀菌剂配合使用,其抗菌效果比单独使用聚六亚甲基胍或绿花白千层精油的效果有显著提高,产生了协同增效的作用。

Description

一种抗菌湿巾的制备工艺
技术领域
本发明涉及化妆品领域,具体涉及一种抗菌湿巾的制备工艺。
背景技术
湿巾是选用湿强柔纤高渗透性基材,经折叠、加湿、包装制成一次性清洁卫生用品,因其具有清洁、保湿皮肤的基本功能以及便于携带等特点成为人们日常生活中必不可少的清洁用品。随着人们生活水平的提高,湿巾的个人消费量逐渐增多,主要应用于旅行、旅游等户外用水不方便的场合,还有家庭婴幼儿的清洁护理等。湿巾产品正向多品类及适用的多途径发展。
近年来湿巾的产量有较快的增长,目前国内市场上有上百个品牌的湿巾产品,年消费量约500-600吨。全国比较正规的生产企业有50多家,另有作坊式的小企业几百家。中高档产品出口较多,国外品牌在我国定点加工的数量也在不断增长。
聚六亚甲基胍(Polyhexamethelenneguanidine Hydrochloride PHMG)是广谱杀毒剂,特点是杀菌力强、作用快速、稳定性好、实际无毒级。0.3%PHMG作用2min即可100%杀死大肠杆菌、金黄色葡萄球菌、白色念球菌、溶血性链球菌;0.1%PHMG作用5min即可杀灭艾滋病毒;0.5%PHMG作用1min即可杀灭艾滋病毒。皮肤刺激试验为0级,无刺激。急性毒性试验:1%PHMG LD50大于5000mg/kgBW属实际无毒级。PHMG属于多胍类高分子聚合物,在水溶液中能产生电离,它的亲水基部分含有强烈的正电性,吸附通常呈负电性的各类细菌病毒,从而抑制了细菌、病毒繁殖,加上聚合物形成的薄膜堵塞了这部分微生物的离子通道,使其迅速窒息死亡,达到最佳的杀菌效果。国内外研究资料表明,PHMG是安全有效杀灭细菌、真菌、病毒的理想消毒剂。
现有技术中虽然已将聚六亚甲基胍用于制备湿巾,但是单用聚六亚甲基胍作为杀菌剂的杀菌效果一般。
发明内容
本发明的目的即是克服现有技术的不足,提供一种杀菌效果显著的湿巾。
本发明解决该技术问题的技术方案是:
一种抗菌湿巾的制备工艺,由以下步骤制备而成:
(1)按如下重量配比称取原料:聚六亚甲基胍0.1-0.5%,绿花白千层精油0.2-0.5%,聚山梨酯-80 10-20%,鲸蜡硬脂醇硫酸酯钠3-10%,丙三醇1-5%,去离子水65-80%;
(2)将聚山梨酯-80和鲸蜡硬脂醇硫酸酯钠溶于去离子水中,加入丙三醇,加热至40-60℃,搅拌均匀,加入聚六亚甲基胍,继续搅拌均匀,降温至室温,加入绿花白千层精油,搅拌均匀,得湿巾液;
(3)将水刺无纺布浸入湿巾液中,取出后包装即得。
所述原料的重量配比优选为:聚六亚甲基胍0.5%,绿花白千层精油0.5%,聚山梨酯-8015%,鲸蜡硬脂醇硫酸酯钠8%,丙三醇2%,去离子水74%。
所述步骤(2)中加热温度优选为55℃。
所述步骤(3)中将水刺无纺布浸入湿巾液中的时间为0.5-1.5h。
本发明的有益效果:
本发明的抗菌湿巾采用聚六亚甲基胍和绿花白千层精油配伍作为抑菌剂,将有机合成杀菌剂和植物提取杀菌剂配合使用,其抗菌效果比单独使用聚六亚甲基胍或绿花白千层精油的效果有显著提高,产生了协同增效的作用。
具体实施方式
实施例1
(1)按如下重量配比称取原料:聚六亚甲基胍0.5%,绿花白千层精油0.5%,聚山梨酯-80 15%,鲸蜡硬脂醇硫酸酯钠8%,丙三醇2%,去离子水74%;
(2)将聚山梨酯-80和鲸蜡硬脂醇硫酸酯钠溶于去离子水中,加入丙三醇,加热至55℃,搅拌均匀,加入聚六亚甲基胍,继续搅拌均匀,降温至室温,加入绿花白千层精油,搅拌均匀,得湿巾液;
(3)将水刺无纺布浸入湿巾液中1h,取出后包装即得。
实施例2
(1)按如下重量配比称取原料:聚六亚甲基胍0.2%,绿花白千层精油0.3%,聚山梨酯-80 12%,鲸蜡硬脂醇硫酸酯钠4%,丙三醇3.5%,去离子水80%;
(2)将聚山梨酯-80和鲸蜡硬脂醇硫酸酯钠溶于去离子水中,加入丙三醇,加热至50℃,搅拌均匀,加入聚六亚甲基胍,继续搅拌均匀,降温至室温,加入绿花白千层精油,搅拌均匀,得湿巾液;
(3)将水刺无纺布浸入湿巾液中1h,取出后包装即得。
实施例3
(1)按如下重量配比称取原料:聚六亚甲基胍0.3%,绿花白千层精油0.4%,聚山梨酯-80 18%,鲸蜡硬脂醇硫酸酯钠8%,丙三醇4%,去离子水69.3%;
(2)将聚山梨酯-80和鲸蜡硬脂醇硫酸酯钠溶于去离子水中,加入丙三醇,加热至45℃,搅拌均匀,加入聚六亚甲基胍,继续搅拌均匀,降温至室温,加入绿花白千层精油,搅拌均匀,得湿巾液;
(3)将水刺无纺布浸入湿巾液中0.5h,取出后包装即得。
实施例4
(1)按如下重量配比称取原料:聚六亚甲基胍0.4%,绿花白千层精油0.2%,聚山梨酯-80 20%,鲸蜡硬脂醇硫酸酯钠6%,丙三醇3%,去离子水70.4%;
(2)将聚山梨酯-80和鲸蜡硬脂醇硫酸酯钠溶于去离子水中,加入丙三醇,加热至60℃,搅拌均匀,加入聚六亚甲基胍,继续搅拌均匀,降温至室温,加入绿花白千层精油,搅拌均匀,得湿巾液;
(3)将水刺无纺布浸入湿巾液中1.5h,取出后包装即得。
试验例一抗菌湿巾的抑菌效果研究
按聚六亚甲基胍1%,聚山梨酯-80 15%,鲸蜡硬脂醇硫酸酯钠8%,丙三醇2%,去离子水74%的配方根据实施例1的方法制备对比例1湿巾,按绿花白千层精油1%,聚山梨酯-80 15%,鲸蜡硬脂醇硫酸酯钠8%,丙三醇2%,去离子水74%的配方根据实施例1的方法制备对比例2湿巾,参照《GB15979-2002一次性卫生用品卫生标准》附录C《产品杀菌性能、抑菌性能与稳定性测试方法》对湿巾进行杀菌率试验,作用时间为5分钟。杀菌实验结果如表1所示:
表1抗菌湿巾的抑菌效果
结果显示,本发明的抗菌湿巾采用聚六亚甲基胍和绿花白千层精油配伍作为抑菌剂,将有机合成杀菌剂和植物提取杀菌剂配合使用,其抗菌效果比单独使用聚六亚甲基胍或绿花白千层精油的效果有显著提高,产生了协同增效的作用。

Claims (1)

1.一种抗菌湿巾的制备工艺,其特征在于,由以下步骤制备而成:
(1)按如下重量配比称取原料:聚六亚甲基胍0.5%,绿花白千层精油0.5%,聚山梨酯-80 15%,鲸蜡硬脂醇硫酸酯钠8%,丙三醇2%,去离子水74%;
(2)将聚山梨酯-80和鲸蜡硬脂醇硫酸酯钠溶于去离子水中,加入丙三醇,加热至55℃,搅拌均匀,加入聚六亚甲基胍,继续搅拌均匀,降温至室温,加入绿花白千层精油,搅拌均匀,得湿巾液;
(3)将水刺无纺布浸入湿巾液中1h,取出后包装即得。
CN201611138062.4A 2016-12-12 2016-12-12 一种抗菌湿巾的制备工艺 Active CN107669508B (zh)

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CN102943006A (zh) * 2012-12-04 2013-02-27 深圳市妍倩科技有限公司 一种具有杀菌抑菌功能的精油皂
CN103070793A (zh) * 2012-09-14 2013-05-01 苏州宝丽洁日化有限公司 一种卫生杀菌湿巾
CN105012161A (zh) * 2014-04-22 2015-11-04 霍锴 一种消毒湿巾

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Publication number Priority date Publication date Assignee Title
CN103070793A (zh) * 2012-09-14 2013-05-01 苏州宝丽洁日化有限公司 一种卫生杀菌湿巾
CN102943006A (zh) * 2012-12-04 2013-02-27 深圳市妍倩科技有限公司 一种具有杀菌抑菌功能的精油皂
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