CN107656068A - A kind of blood detector - Google Patents
A kind of blood detector Download PDFInfo
- Publication number
- CN107656068A CN107656068A CN201710876252.4A CN201710876252A CN107656068A CN 107656068 A CN107656068 A CN 107656068A CN 201710876252 A CN201710876252 A CN 201710876252A CN 107656068 A CN107656068 A CN 107656068A
- Authority
- CN
- China
- Prior art keywords
- sample
- measurement
- module
- reactive protein
- reaction vessel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0474—Details of actuating means for conveyors or pipettes
- G01N2035/0491—Position sensing, encoding; closed-loop control
- G01N2035/0493—Locating samples; identifying different tube sizes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4737—C-reactive protein
Abstract
A kind of blood detector, including c reactive protein measurement module, sample collection and distribute module, fluid path support module and control and message processing module.C reactive protein measurement module includes reaction vessel, measurement container and hemolytic agent and transports pipeline, reaction vessel transports pipeline by sample with measurement container and controllably connected, control and message processing module also control fluid path support module to provide power, hemolytic agent is transported into pipeline by hemolytic agent to add in reaction vessel, hemolytic agent is reacted with the blood sample and latex reagent added later in reaction vessel, then transport pipeline by sample sample is transported in measurement container, so as to improve the measurement efficiency of c reactive protein parameter.
Description
The application is divisional application, and the application number of its original application is 201480039632.7, and the applying date is July 1 in 2014
Day, denomination of invention is " a kind of whole blood sample detection method and blood detector ".
Technical field
The application is related to blood testing and analysis field, and in particular to a kind of blood detector, for supporting unit to use
Whole blood sample carries out CRP detections.
Background technology
Now, often need to obtain the blood routine parameter of patient blood and CRP (C reaction eggs simultaneously in the clinical diagnosis of hospital
The testing result of parameter in vain).
In existing most of blood testing instruments, the detection that the blood routine such as blood count, classification detects with CRP is to make
Carried out with different types of sample on different instruments, blood count, classification are typically using whole blood sample in blood cell point
Carried out in analysis, and CRP is then measured using serum sample on biochemical analysis or Special Protein Analyzer.And due to blood routine and
CRP is clinically usually used in combination, therefore Hospitals at Present needs to gather sample twice or increase blood sampling volume on patient, respectively
Tested on different machines.So caused suffering for patient larger, and need to detect on two machines, checked operation
Trouble.
In order to solve the above problems, it is necessary to develop on one machine using same whole blood sample detection blood routine ginseng
The instrument of number and CRP parameters.Because the measuring method of these parameters is different, it is therefore desirable to which multiple Measurement channels support different parameters
Measurement.
The product of unit is supported at present, whole blood sample can be used to carry out blood routine parameter measurement and CRP parameter measurements, but its
Test speed is slower, highest test speed be only 20 samples/when, it is impossible to meet the requirement to efficiency in clinical examination.
The content of the invention
The application proposes a kind of blood detector, can use whole blood sample, be rapidly completed the measurement of CRP parameters.
According to the application's in a first aspect, the application provides a kind of blood detector, including:
C reactive protein measurement module, for providing measurement place for allocated sample, to allocated sample progress with
Obtain c reactive protein parameter for the purpose of measurement and export measurement result, the c reactive protein measurement module includes multiple measurements
Passage, each Measurement channel includes reaction vessel, measurement container, hemolytic agent transports pipeline and sample transports pipeline, the reaction
Container transports pipeline by sample with measurement container and controllably connected, and hemolytic agent transports pipeline and is used to hemolytic agent adding reaction appearance
In device;
Sample collection and distribute module, c reactive protein is distributed to for gathering whole blood sample, and by the whole blood sample of collection
Multiple Measurement channels of measurement module;
Fluid path support module, fluid path is provided and supported for sample collection and distribute module and each measurement module;
Control and message processing module, are respectively coupled to sample collection and distribute module, c reactive protein measurement module and liquid
Road support module, for controlling, sample collection and distribute module gather whole blood sample and distribution whole blood sample, control fluid path are supported
Module carries out fluid conveying, the measurement result for receiving the output of c reactive protein measurement module and measurement result is handled;In sample
During this continuous measurement, the control and message processing module control the sample collection and distribute module collection whole blood sample, and
By the whole blood sample of collection according to the default reaction vessel for being sequentially assigned to a Measurement channel in turn, the control and information
Processing module also controls the fluid path support module to provide power, and hemolytic agent is transported described in pipeline addition by the hemolytic agent
In reaction vessel, the hemolytic agent is reacted with the whole blood sample and latex reagent added later in the reaction vessel,
Then transport pipeline by the sample sample that reaction vessel exports is transported in measurement container, at the control and information
Reason module controls sample collection to start next whole blood with distribute module when current sample does not complete c reactive protein parameter measurement
The collection and distribution of sample, by the whole blood sample of collection according to predetermined amount distribute to c reactive protein measurement module another
Measurement channel, making c reactive protein measurement module, existence time overlaps at least in the measurement process to two distribution samples.
According to the second aspect of the application, the application provides another blood detector, including:
C reactive protein measurement module, for providing measurement place for allocated sample, to allocated sample progress with
Obtain c reactive protein parameter for the purpose of measurement and export measurement result, the c reactive protein measurement module include one reaction hold
Device, at least one measurement container, sample transport pipeline and hemolytic agent transports pipeline, and the hemolytic agent transports pipeline and is used for haemolysis
Agent is added in the reaction vessel, and the reaction vessel is used for the whole blood sample and breast for receiving sample collection and distribute module distribution
Glue reagent, the reaction vessel transport pipeline by sample with measurement container and controllably connected, and measurement container is used to be reaction solution
Measurement place is provided;
Sample collection and distribute module, c reactive protein is distributed to for gathering whole blood sample, and by the whole blood sample of collection
Reaction vessel in measurement module;
Fluid path support module, fluid path is provided and supported for sample collection and distribute module and c reactive protein measurement module;
Control and message processing module, are respectively coupled to sample collection and distribute module, c reactive protein measurement module and liquid
Road support module, for controlling, sample collection and distribute module gather whole blood sample and distribution whole blood sample, control fluid path are supported
Module carries out fluid conveying, the measurement result for receiving the output of c reactive protein measurement module and measurement result is handled;In sample
During this continuous measurement, the control and message processing module control sample collection and distribute module collection whole blood sample, and will adopt
The whole blood sample of collection distributes to the reaction vessel in c reactive protein measurement module, and the control and message processing module also control
Fluid path support module provide power, by hemolytic agent by hemolytic agent transport pipeline add reaction vessel in, the hemolytic agent with slightly
The whole blood sample and latex reagent added afterwards is reacted in reaction vessel, then transports pipeline by reaction vessel by sample
The sample of output is transported in measurement container.
In one embodiment, the control and message processing module do not complete current sample in c reactive protein measurement module
Sample collection is controlled to start the collection and distribution of next whole blood sample with distribute module during this c reactive protein parameter measurement,
Next whole blood sample of collection is distributed into the reaction vessel in the c reactive protein measurement module.
In a further embodiment, the c reactive protein measurement module includes multiple measurement containers, is continuously surveyed in sample
During amount, pipeline is transported by sample the sample that reaction vessel exports sequentially is transported to multiple measurement containers in turn according to default
In one, it is described control and message processing module current sample do not complete c reactive protein parameter measurement when control sample
Collection starts the collection and distribution of next sample with distribute module, and it is anti-that according to predetermined amount the whole blood sample of collection is distributed into C
The reaction vessel of protein measurement module is answered, makes c reactive protein measurement module at least in the measurement process to two distribution samples
Existence time overlaps.
In another embodiment, c reactive protein measurement module also includes CRP measuring cell waste liquid output mechanisms and reaction tank
Waste liquid output mechanism, CRP measuring cell waste liquid output mechanisms and measurement reservoir, for discharging the waste liquid measured in container, instead
Pond waste liquid output mechanism is answered to be connected with reaction vessel, for discharging the waste liquid in reaction vessel.
In a further embodiment, after the reaction vessel completes operation, control and message processing module control liquid
Road support module drives the waste liquid in the reaction vessel to be discharged by reaction tank waste liquid output mechanism;And/or hold in the measurement
After device completes operation, the waste liquid in control and the message processing module control fluid path support module driving measurement container is by described
Measure the discharge of CRP measuring cell waste liquids output mechanism.
In a further embodiment, the reaction vessel complete operation after and it is described measurement container do not complete current sample
During this c reactive protein parameter measurement, control and message processing module control fluid path support module to drive the reaction vessel
In waste liquid by reaction tank waste liquid output mechanism discharge;And/or it is described measurement container complete operation after and the reaction vessel
When not completing the reaction of next whole blood sample, control and message processing module control fluid path support module to drive the measurement
Waste liquid in container is discharged by the measurement CRP measuring cell waste liquids output mechanism.
In another embodiment, the fluid path support module is additionally operable to not complete c reactive protein parameter in current sample
The reaction vessel is cleaned during measurement, so that next whole blood sample of collection is distributed to this by the sample collection and distribute module
Reaction vessel.The fluid path support module is additionally operable to clean the measurement after current sample completes c reactive protein parameter measurement
Container, so that next sample of reaction vessel output enters the measurement container.
Brief description of the drawings
Fig. 1 is a kind of blood detector Fault profile figure disclosed in the embodiment of the present application 1;
Fig. 2 is a kind of blood detector structural principle block diagram disclosed in the embodiment of the present application 1;
Fig. 3 is another structural principle block diagram of the embodiment of the present application 1C reactive protein measurement modules;
Fig. 4 is the continuous measurement strategies schematic diagram of the sample of the embodiment of the present application 1;
Fig. 5 is the sample collection of the embodiment of the present application 1 and distribute module structural representation;
Fig. 6 a and Fig. 6 b are the sample collection of the embodiment of the present application 1 and distribute module segment assignments sample schematic diagram;Wherein,
Fig. 6 a are the sample size schematic diagrames that the embodiment of the present application 1 disposably gathers;
Fig. 6 b are sample size schematic diagram of the embodiment of the present application 1 after primary distribution;
Fig. 7 is the auto injection module schematic top plan view of the embodiment of the present application 2;
Fig. 8 is the latex reagent memory module configuration simplified schematic diagram of the embodiment of the present application 3;
Fig. 9 is the method flow diagram that the embodiment of the present application 3 detects to whole blood sample.
Embodiment
In the embodiment of the present application, CRP parameter measurement functions and blood routine measurement function are integrated into same blood to examine
Survey on instrument, CRP measurements and blood routine measurement all use whole blood sample, CRP measurements using first by whole blood sample and hemolytic agent mixing,
Then the mode for adding latex reagent obtains.During using this metering system, the time of measuring of CRP parameters is joined more than blood routine
Several time of measuring, such as same sample, blood routine parameter measurement needs 1 minutes, and CRP parameter measurements then need
2 minutes, if waiting CRP parameter measurements after blood routine parameter measurement is completed, necessarily reduce the survey of blood routine parameter
Measure speed.In order to quickly complete the measurement of blood routine parameter and CRP parameters on same machine, in the embodiment of the present application, C
Reactive protein measurement module includes multiple Measurement channels, and in the continuous measurement process of sample, multiple Measurement channels are by according to pre-
If rotation adds sample and measured.The application is illustrated in particular embodiments below in conjunction with the accompanying drawings.
Embodiment 1:
Fig. 1 and Fig. 2 are refer to, is a kind of structure of blood detector disclosed in the present embodiment.Wherein, Fig. 1 is blood testing
Instrument dimensional structure diagram, Fig. 2 are blood detector structural principle block diagram;Dot-and-dash arrowhead line in Fig. 2 moves towards for electric signal, real
Arrow line moves towards for fluid path.The blood detector includes:Blood routine measurement module 1 (being marked not shown in Fig. 1), c reactive protein
Measurement module (hereinafter also referred to CRP measurement modules) 2, sample collection (are not shown with distribute module 3, fluid path support module 8 in Fig. 1
Go out mark) and control and message processing module 9 (being marked not shown in Fig. 1).Wherein:
Blood routine measurement module 1 is used to provide measurement place for allocated sample, allocated sample is carried out to obtain
Measurement for the purpose of at least one blood routine parameter and export measurement result.Fig. 1 is refer to, in a kind of specific embodiment,
Blood routine measurement module 1 can need to be further subdivided into each seed measurement module according to measurement:WBC category measurements module 11,
WBC/HGB measurement modules 12 and RBC/PLT measurement modules 13.WBC category measurements module 11 is used to provide to allocated sample
The place of reaction is completed, and measures five classification results for obtaining WBC;WBC/HGB measurement modules 12 are used to complete WBC (white
Blood cell, leucocyte) count and morphological parameters measurement, and have concurrently measurement HGB (hemoglobin, hemoglobin) work(
Energy;RBC/PLT measurement modules 13 are used to complete RBC (red blood cell, red blood cell), PLT (blood platelet, blood
Platelet) count and morphological parameters measurement.It should be noted that above-mentioned each submodule (11,12 and 13) can use it is existing
Metering system realize, in actual blood routine measurement process, the measurement submodule of other blood routines can also be increased, or subtract
Few some above-mentioned submodules.
C reactive protein measurement module 2 is used to provide measurement place for allocated sample, to the sample progress that is allocated with
Obtain c reactive protein parameter for the purpose of measurement and export measurement result.After sample is assigned to c reactive protein measurement module 2,
Hemolytic agent first with addition is reacted, and latex reagent is then added in reaction solution, finally by Photoelectric Detection to adding
The reaction solution of latex reagent carries out light transit dose or amount of light scatter detection, and exports measurement result.To be a sample in the application
This offer is referred to as a Measurement channel, a Measurement channel from reacting, measure measurement result and export the facility of this process
Generally include:It can be achieved to provide the reaction vessel of reacting environment for sample and reagent, can be achieved to provide measurement place for reaction solution
Measurement container, and can realize and the reaction solution in measurement container is measured and exports the detection means of measurement result.Having
When body is realized, reaction vessel and measurement container can be also combined into one, you can, can also as the reacting environment of sample and reagent
Measurement place as reaction solution.
In the embodiment of the present application, c reactive protein measurement module includes at least two measurement containers and at least a set of detection dress
Put, to realize multiple Measurement channels, each Measurement channel includes a measurement container, and measurement container is used for for allocated sample
Measurement place is provided, detection means carries out the survey for the purpose of obtaining c reactive protein parameter to the sample in measurement container respectively
Measure and export measurement result.Due to being needed reagents such as whole blood sample, hemolytic agent and latex reagents first before c reactive protein measurement
Mix and pass through the reaction of preset time.Therefore in some specific embodiments, c reactive protein measurement module includes at least one
Reaction vessel, at least two measurement containers and at least a set of detection means, reaction vessel and measurement reservoir, for be divided
The sample and reagent matched somebody with somebody provide reacting environment, are distributed after sample and reagent reacting to be dispensed according to preset order to survey
Measure and c reactive protein measurement is carried out in container.In the specific embodiment having, reaction vessel and detection means are with measuring container one by one
Corresponding, i.e., each Measurement channel includes a reaction vessel, a detection means and a measurement container.In other specific embodiment
In, reaction vessel and/or detection means not correspond with measurement container, such as reaction vessel and/or the number of detection means
Less than measurement container, reaction vessel and/or detection means are shared amount by multiple Measurement channels.In this case, a measurement is logical
Road includes a measurement container, the reaction vessel shared with other Measurement channels and/or detection means.In some specific implementations in addition
In example, can also there is no reaction vessel in c reactive protein measurement module, measurement container not only provided reacting environment but also provided measurement field
Institute.
Sample collection is used to gather whole blood sample with distribute module 3, and the sample of collection is distributed into blood routine measurement mould
Block 1 and c reactive protein measurement module 2.When Measurement channel includes reaction vessel, sample collection will gather with distribute module 3
Sample distribute to reaction vessel;When not including reaction vessel in Measurement channel, sample collection and distribute module 3 are by collection
Sample distributes to measurement container.
Fluid path support module 8 provides fluid path and supported for sample collection and distribute module and each measurement module.It is being embodied
In example, fluid path support module 8 generally includes:Valve, pump, and/or syringe etc., it is main in blood detector to realize conveying sample
Originally, the transportation function such as reagent and discharge waste liquid.
Control and message processing module 9 are respectively coupled to sample collection and supported with distribute module 3, each measurement module and fluid path
Module 8, for controlling sample collection to carry out fluid with the collecting sample of distribute module 3 and distribution sample, control fluid path support module 8
Convey, receive the measurement result of each measurement module output and measurement result is handled.In the present embodiment, at control and information
The sample gathered every time is assigned to blood routine measurement module by reason module control sample collection with distribute module according to predetermined amount
With a Measurement channel of c reactive protein measurement module, the Measurement channel determines according to default order in turn, so that
One in multiple measurement containers in c reactive protein measurement module sequentially obtains different distribution samples in turn according to default
This.
The measurement of blood routine and c reactive protein parameter is illustrated with a kind of concrete structure of c reactive protein measurement module below
Process.
As shown in figure 1, c reactive protein measurement module includes two Measurement channels 21,22, the Measurement channel of one of them
Composition schematic diagram is as shown in figure 3, mainly include a reaction vessel 221, a sample transport tube road 222, one measurement container 223, one
Detection means, CRP measuring cell waste liquids output mechanism 224, reaction tank waste liquid output mechanism 225, hemolytic agent transport pipeline 226, instead
To answer container 221 to transport pipeline 222 by sample with measurement container 223 controllably to connect, detection means is photoelectric detector, including
Light transmitting terminal 227 and light test side 228, in the present embodiment, light transmitting terminal 227 is light source, can irradiate measurement container for launching
Light, light test side 228 is photoelectric sensor, for receiving the transmitted light of measured container.In the present embodiment, light transmitting terminal
227 and light test side 228 be separately positioned on the relative both sides of measurement container 223.Two Measurement channels can use above-mentioned identical
Structure, can also use in different structures, such as another Measurement channel does not have reaction vessel, and complete in container is measured
Into the reaction and measurement of sample and reagent.It will be appreciated by those skilled in the art that the scattering of measured container can also be detected
The position of light, light transmitting terminal and light test side can adjust as needed.
Its basic functional principle is:After starting measurement, sample is placed in sample position, by sample collection and distribution mould
Block 3 carries out sample absorption, and then sample collection can be moved with the moving parts in distribute module 3 on each measurement module, will
Required sample is respectively allocated in corresponding measurement module, as CRP measurement modules 2, WBC category measurements module 11, WBC/HGB are surveyed
Measure module 12 and RBC/PLT measurement modules 13.Each measurement module soon starts the survey of corresponding parameter after sample is allocated
Amount, cleaning can be carried out after completing to measure and enters holding state, waits the beginning of measurement next time.
(it is respectively 2 minutes and 1 point because the CRP parameter measurement times of single sample are longer than blood routine parameter time of measuring
Clock), in order to simultaneously measure both parameters when can realize 60 samples/when high test speed, the present embodiment employ CRP measurement
The design that module binary channels alternately measures.Its concrete principle is:By the first Measurement channels of CRP 21 and the second Measurement channels of CRP 22
The two independent CRP Measurement channels integrate, and constitute CRP measurement modules 2.When sample continuously measures, often gather
Sample, distribute to the sample of collection is rationed to all blood routine measurement module and in turn in CRP measurement modules
A Measurement channel, for each blood routine measurement module, opened after it terminates the blood routine measurement of sample
Begin next sample blood routine measurement.For two Measurement channels of c reactive protein measurement module, the CRP of each sample
Measurement be successively in two CRP Measurement channels alternately, two distribution samples CRP measurement process existence times hand over
Folded, this makes it possible to cause each sample after blood routine parameter measurement is completed the CRP of current sample need not be waited to join again
The completion of number measurement can start the blood routine measurement of next sample.Final each sample completes the survey of oneself CRP parameter
After amount, blood routine and CRP parameters are exported simultaneously, whole measurement results of one sample of output per minute are realized, so as to improve
The speed of integrated testability, with reach 60 samples/when high test speed.
It refer to Fig. 4.Assuming that the time that CRP parameter measurements are spent is 2 minutes, the time of blood routine parameter measurement is 1
Minute.In Fig. 4,1~sample of sample 8 be continuous acquisition sample to be measured, 0min represent measurement start time, 1min~
9min represents measurement start time elapsed time (min be chronomere, minute).The blood routine parameter measurement of 8 samples
Serial successively in blood routine measurement module 1 to complete, each sample takes 1min.The CRP parameter measurements of 1~sample of sample 8 are then
In CRP Measurement channels 1 and CRP Measurement channels 2 alternately, each sample takes 2min.As shown in figure 3, sample collection with
Distribute module 3 first distributes sample 1 to the first Measurement channels of CRP 21 the CRP parameter measurements for carrying out sample 1, and then, sample is adopted
Collection distributes sample 2 to the second Measurement channels of CRP 22 the CRP parameter measurements for carrying out sample 2 with distribute module 3, then again by sample
Sample 4 is distributed to the second Measurement channels of CRP 22 carry out CRP parameter surveys afterwards by this 3 distribution again to the first Measurement channels of CRP 21
8 samples of collection are distributed to two surveys by amount, by that analogy, sample collection in turn with distribute module 3 according to default order
Measure passage (the first Measurement channels of CRP 21 and the Measurement channels 22 of CRP second).In said process, the blood routine parameter of each sample
To complete to measure earlier than CRP parameters 1min, but all measurement results of the sample are exported together when CRP parameters are completed.One
Denier starts measurement, whole measurement results of first sample (sample 1) be after first sample starts to measure 2min (due to
CRP parameter measurements need time-consuming 2 minutes) export, whole measurement results of a sample are hereafter exported per 1min.Certainly, finally
Whole measurement results of one sample t=1min should export after blood routine parameter measurement, and wherein t value is surveyed for CRP parameters
Amount short time consumption subtracts blood routine parameter measurement short time consumption.As can be seen here, if 60 samples are continuously measured, on 60 minutes left sides
The measurement result of right exportable 60 whole samples, measuring speed is about 60 samples/hour.It should be noted that it is simply
Be easy to those of ordinary skill in the art understand technical scheme and for above-mentioned example, it is impossible to regard as in the whole of technical scheme
Hold, for example, the Measurement channel of CRP parameter measurements can also be multiple, blood routine parameter measurement short time consumption and CRP parameter measurements
Short time consumption can also be other time.In an instantiation, sample collection includes travel mechanism and fixation with distribute module 3
Sampling needle in travel mechanism, travel mechanism drive sampling needle to be moved in the horizontal direction with vertical direction.Fig. 5 is refer to, is
Sample collection and a kind of exemplary construction schematic diagram of distribute module 3 in the present embodiment.Sample collection includes with distribute module 3:Gu
Fixed rack 31, X-direction guide rail 32, X-direction transmission device 33, travel(l)ing rest 34, Z-direction guide rail 35, Z-direction transmission mechanism 36,
Sampling needle 37 and swab 38.Wherein, fixed support 31 is connected with the fixed support of detector, certainly, in other embodiments,
Directly it can also be replaced using the fixed support of detector;Travel(l)ing rest 34 passes through X-direction guide rail 32, X-direction running part 33
Formed and be slidably connected with fixed support 31 so that travel(l)ing rest 34 and part mounted thereto can move shape in X direction
Into travel mechanism, its power comes from X-direction transmission device 33;Sampling needle 37 passes through Z-direction guide rail 35, Z-direction transmission mechanism 36
Formed and be slidably connected with travel(l)ing rest 34 so that sampling needle 37 can make Z-direction movement relative to travel(l)ing rest 34;The work of swab 38
With to clean the outer wall of sampling needle 37, when sampling needle 37 carries out Z-direction motion, swab 38 provides liquid by fluid path support module 8
Cleaning sampling needle outer wall simultaneously takes liquid after cleaning away.
Sample collection and the operation principle of distribute module 3 are as follows:
1. sample collection
By the driving of X-direction transmission device 33, travel(l)ing rest 34 is moved to sample gettering site 49, passed by Z-direction
Sampling needle 37 is moved down into the test tube of sample gettering site 49 by motivation structure 36.Now, sampling needle 37 can pass through fluid path branch
The default quantitative sample of power absorption for holding the offer of module 8 is stored in inside sampling needle 37, completes sample collection action.
2. cleaned after sample collection
After sample collection, the outside of sampling needle 37 is unavoidably stained with a small amount of sample, when the uphill process of sampling needle 37,
Swab 38 will clean the outer wall of sampling needle 37, avoid outer wall sample from causing quantitative influence.
3. sample distributes
Driven by X-direction transmission device 33, travel(l)ing rest 34 is moved to the top of corresponding measurement module;By Z side
Sampling needle 37 is moved down into measurement module to transmission mechanism 36.After sampling needle needle point reaches measurement module inside, liquid
Road support module 8 provides power, and the sample being stored in inside sampling needle 37 is quantitatively released, is added in measurement module, completes
Sample distribution acts.
It should be noted that above-mentioned Z-direction is vertical direction, X-direction is one kind of horizontal direction, in other embodiments
In, horizontal direction can also be Y-direction, or X-direction and Y-direction, for example, all increase drive rail in X-direction and Y-direction,
And increase Y-direction transmission device and just can realize the movement of travel mechanism's (such as travel(l)ing rest 34) in the x-direction and the z-direction;For another example,
X-direction transmission device 33 can also be substituted by the tumbler rotated in the horizontal plane.
In a preferred embodiment, each blood routine measurement module 1, c reactive protein measurement module 2 and the edge of sample gettering site 49
The motion track arrangement of the horizontal direction of sampling needle 37.Sample gettering site 49 is preferably provided at the horizontal direction moving rail of sampling needle
The position of the close initiating terminal of mark.
In a preferred embodiment, sample collection gathers a sample with the sample collection of distribute module 3 and distribute module, so
Segment assignments give each blood routine measurement module 1 and c reactive protein measurement module 2 afterwards.Fig. 6 a and Fig. 6 b are refer to, due to blood routine
What the sample size in measurement module 1 and c reactive protein measurement module 2 required for projects measurement was to determine, therefore, sample collection
Sample size required for being measured with distribute module 3 according to each module, disposable collection finish.Assuming that in a clinical detection
In, blood routine parameter measurement needs to measure two projects (such as WBC classification items and WBC/HGB measure the items), is respectively necessary for sample
The sample size that this amount is V1 and V2, CRP parameter measurement need is V3, then the sample that sample collection disposably gathers with distribute module 3
This amount is more than or equal to V1+V2+V3, as shown in Figure 6 a.Then, sample collection measures mould with distribute module 3 according to each blood routine
Sample size needed for block 1 and c reactive protein measurement module 2 distributes to each measurement container.Such as, to the measurement of WBC classification items
The sample that one section of amount of container allocation is V1, now sample collection there remains V2+V3 sample with distribute module 3, as shown in Figure 6 b;
Remaining V2+V3 two sections of samples are respectively allocated to WBC/HGB measure the items and CRP parameters by sample collection with distribute module 3
The measurement container of measurement.In other embodiments, according to the needs of measure the item, more multistage, or reduction can also be divided into
Hop count.The advantages of distributing sample in this way is, does not need gradually collecting sample to be assigned in each measurement container, passes through
The mode of disposable collecting sample more saves the time relative to the mode of multi collect sample, improves measurement efficiency.More enter
One step, to avoid the sample cross contamination being assigned in different measurement containers, there is the throwing of preset vol between two sections of samples
Abandon sample.Into contact with reagent sample abandon after, this section of sample can be avoided to influence the measurement result of next measurement module,
Ensure that cross pollution is not present in the sample used in two adjacent measurement modules.
When CRP is measured, hemolytic agent transports pipeline under the driving of fluid path support module 8, by hemolytic agent and adds hemolytic agent
Enter in CRP reaction vessels, it is reacted with the blood sample and latex reagent added later in CRP reaction vessels, is then passed through
Sample transports pipeline and sample is transported in CRP measurement containers, and the detection of light test side is sent by light transmitting terminal and measured by CRP
Light emitted by container and sample liquid;After reaction vessel and measurement container complete operation, under the driving of fluid path support module,
Waste liquid discharges CRP reaction vessels and CRP respectively by reaction vessel waste liquid output mechanism and measurement container waste liquid output mechanism respectively
Measure container.When conveying hemolytic agent into reaction vessel, from prior art different, this implementation using the scheme of sampling needle conveying
Pipeline is transported using special hemolytic agent in example hemolytic agent is added into reaction vessel, its purpose is to save because sampling needle is drawn
With the time shared by distribution reagent, CRP measuring speed is improved, so as to further improve overall test speed.
Each measurement module is cleaned before starting after measurement terminates with next sample measurement.
In other instantiations, multiple Measurement channels can share reaction vessel in c reactive protein measurement module, instead
Answer container to transport pipeline by different samples and controllably connect different measurement containers.Detection means can also be it is shared,
Such as a selectable annular mechanism is set in c reactive protein measurement module, multiple measurement containers are arranged into annular mechanism
One row, can only have a detection means, the detection means is arranged on into annular in this case in c reactive protein measurement module
In the rotation approach of mechanism, measurement container rotates with annular mechanism, stops one by one by detection means and for detection, detection dress
Put to stop at its detection zone measurement container in reaction solution detect.
Blood detector disclosed in the present embodiment, by setting multiple Measurement channels, energy in c reactive protein measurement module
Enough when unit carries out haemocyte conventional detection and CRP detections using whole blood sample, effectively utilize and wait c reactive protein to measure
Time carries out the haemocyte conventional detection of other samples, so that the measurement of each sample blood routine parameter and c reactive protein measurement
It can cooperate, plan as a whole blood routine parameter measurement and c reactive protein time of measuring, improved measuring speed.
Embodiment 2:
Unlike the present embodiment and above-described embodiment, blood detector disclosed in the present embodiment also includes auto injection mould
Block 4, as shown in figure 1, auto injection module 4 is sample collection and distribute module 3 continuous sample is provided and complete sample load and
Unloading, auto injection module 4 are preferably provided at the front end of blood detector.Fig. 7 is refer to, signal is overlooked for auto injection module
Figure, mainly includes:Rack for test tube conveying mechanism 41, load position detecting mechanism 42, rack for test tube loader mechanism 43, rack for test tube feel trim actuator
44th, test tube whether there is testing agency 45 and test tube bar code acquisition of information mechanism 46.The course of work is:Rack for test tube transport portion 41 is along X
The rack for test tube for placing test tube is delivered to loading area 410 by direction, after loading position detecting mechanism 42 detects rack for test tube in place,
Rack for test tube is entered examination by rack for test tube by rack for test tube loader mechanism 43 along Y-direction by the test tube position on rack for test tube successively mobile test tube shelf
Pipe detecting position 47, sample mix position 48 and sample gettering site 49;When each test tube placement location on rack for test tube reaches test tube inspection
During location 47, test tube, which whether there is testing agency 45, can all detect whether the position has test tube, while test tube bar code acquisition of information mechanism
46 can scan the bar code on test tube;, can be by when the test tube if detecting test tube when the position is moved to 48 samples and mixes position
Mixing module in device completes the mixing of test tube, can be by sample collection and distribution then when being moved to sample gettering site 49
Module 3 carries out the absorption of sample;When last test tube position of whole rack for test tube removes sample gettering site 49, rack for test tube unloading
Opposite direction push-in unloading area 411 of the mechanism 44 by rack for test tube in X direction, completes the unloading of whole rack for test tube sample.
In summary, the workflow of whole auto injection module 4 is followed successively by:
1. holding test tubes and rack for test tube, start auto injection program;
2. test tube is delivered to rack for test tube and loads position;
3. rack for test tube loads, test tube is moved into test tube detecting position 47 successively, sample mixes position 48 and sample gettering site 49;
4. detecting the presence of test tube in test tube detecting position 47, when having detected test tube, the test tube bar code is scanned;
5. mixing position 48 in sample, if there is test tube, sample mixing is carried out, otherwise directly moves into sample gettering site 49;
6. in sample gettering site 49:If there is test tube, sample absorption is carried out;
7. if current sample is located at last test tube position of current rack for test tube, rack for test tube is unloaded.
In a kind of specific embodiment, sample gettering site 49 should be preferably provided at the horizontal direction motion track of sampling needle
Initiating terminal.
In a preferred embodiment, the X-direction of auto injection module 4 should be with sample collection and the X-direction of distribute module 3
Unanimously.
Blood detector disclosed in the present embodiment, the automatic of blood detector is improved by increasing auto injection module 4
The management of change degree, more conducively sample (especially number of samples is various), so as to further increase the blood routine of whole blood sample
With the overall measuring speed of CRP parameters.
Embodiment 3:
Unlike the present embodiment and above-described embodiment, blood detector is also deposited including latex reagent disclosed in the present embodiment
Module 5 is stored up, as shown in figure 1, latex reagent memory module 5 is used to provide Cord blood environment for latex reagent, latex reagent is deposited
Storage module 5 be arranged on blood detector closer to detector edge and away from internal position.By latex reagent memory module 5
The advantage for the position being arranged far from inside detector is, can not only be convenient for changing latex reagent, and changing latex
It during reagent, can avoid user that hand is stretched into instrument internal, reduce risk of the user by biological pollution.
In a preferred embodiment, Fig. 7 is refer to, latex reagent memory module 5 can be arranged on auto injection module 4
Sample loading area 410 and sample unloading area 411 between, latex reagent and sample is shared sampling needle to facilitate, and simplification is adopted
The shift motion of sample pin.
In a kind of specific embodiment, Fig. 8 is refer to, latex reagent memory module 5 includes:Refrigeration mechanism 51 and Leng Shimen
52。
The inside of refrigeration mechanism 51 has cool room 53, and side has opening 54, for providing low temperature for latex reagent.
Cold house's door 52 is used to close cool room at the lateral opening of cool room, is set on cold house's door towards the one side of cool room
It is equipped with latex reagent and places position 50, cold house's door can makes latex reagent placement position expose outside measuring instrument or incite somebody to action under stress
Latex reagent places position and is closed to cool room.
In one embodiment, cold house's door and refrigeration mechanism are split-type structural, and cold house's door passes through push-and-pull and/or upset
Mode away from cool room and can expose outside measuring instrument or by close to cool room and closing cool room outside measuring instrument.Such as
Cold house's door 52 away from cool room and can expose outside measuring instrument under stress, and now, cold house's door 52 is open mode, from
And it is easy to user to contact latex reagent and places position 50;Cold house's door 52 is being freezed in the presence of by opposing force by close outside measuring instrument
Cool room is simultaneously closed in room, and now, latex reagent is placed position 50 and is located in cool room cavity.
In a preferred embodiment, the blood detector can further include urgent sample and place position 55, urgent sample
This placement position 55 is arranged on one side of the cold house's door 52 backwards to cool room.Now, urgent sample places the meeting of position 55 prior to latex reagent
The outside that position 50 is exposed to blood detector is placed, the starting point using this design is, in clinical detection, is examined to blood
Survey instrument add urgent sample frequency be higher than add to blood detector/change latex reagent, facilitated using this design tight
The measurement of anxious sample.
Below using continuous two samples (sample 1 and sample 2) and meanwhile measure whole blood sample blood routine parameter and CRP parameters as
Example illustrates, wherein, WBC category measurements module, WBC/HGB measurement modules and RBC/PLT are included with blood routine measurement module
Exemplified by measurement module, Fig. 9 is refer to, flow is as follows:
Step 1, start measurement, the auto injection of sample 1 is with mixing.After startup is measured, auto injection module 4 presses embodiment
Workflow described in 2 completes the sample introduction of sample 1, test tube whether there is detection, test tube bar code acquisition of information and sample mix.
Step 2, sample 1 are drawn.After test tube reaches sample gettering site 49, sample collection passes through X-direction with distribute module 3
Transmission device 33 is driven, and travel mechanism's (for example travel(l)ing rest 34) is moved into sample gettering site 49, passes through Z-direction transmission mechanism
36 are moved down into needed for blood routine parameter and CRP parameter measurements sampling needle 37 in the test tube of sample gettering site 49 once
Sample is drawn into sampling needle 37.Sampling needle rises to elemental height, while swab 38 under the driving of Z-direction transmission mechanism 36
Clean the outer wall of sampling needle 37.
CRP hemolytic agents are added in step 3, CRP Measurement channels 1.Fluid path support module 8 provides power, and CRP hemolytic agents are added
Enter in the CRP Measurement channels 1 in c reactive protein measurement module 2.
Step 4, CRP Measurement channels 1 divide blood.Under the driving of X-direction transmission device 33, travel(l)ing rest 34 is moved to CRP surveys
The top of passage 1 is measured, sampling needle 37 is moved down into CRP Measurement channels 1 by Z-direction transmission mechanism 36, adds CRP measurements
Required blood sample.Blood sample starts sample haemolysis after adding CRP Measurement channels 1, is ready for follow-up CRP measurements.Sampling needle
Elemental height is risen under the driving of Z-direction transmission mechanism 36, while swab 38 cleans the outer wall of sampling needle 37.
Step 5, WBC category measurement modules divide blood.Under the driving of X-direction transmission device 33, travel(l)ing rest 34 is moved to WBC
Sampling needle 37, is moved down into WBC category measurements module 11 by the top of category measurement module 11 by Z-direction transmission mechanism 36
Carry out point blood and start WBC category measurements.After complete component blood, sampling needle 37 rises under the driving of Z-direction transmission mechanism 36
Elemental height, while swab 38 cleans the outer wall of sampling needle 37.
Step 6, WBC/HGB measurement modules divide blood.Under the driving of X-direction transmission device 33, travel(l)ing rest 34 is moved to
The top of WBC/HGB measurement modules 12, WBC/HGB measurement modules are moved down into by Z-direction transmission mechanism 36 by sampling needle 37
The module and RBC/PLT measurement modules 13 are measured into required blood sample in 12 to distribute to wherein.
Step 7, the sample drawn after being diluted in WBC/HGB measurement modules 12 are distributed to RBC/PLT measurement modules 13.In blood
After sample completes dilution, fluid path support module 8 provides power, and the part of dilution sample of WBC/HGB measurement modules 12 is drawn to sampling
In pin 37.Sampling needle 37 rises to elemental height under the driving of Z-direction transmission mechanism 36, and then X-direction transmission device 33 drives
Dynamic travel(l)ing rest 34 is moved to the top of RBC/PLT measurement modules 13, is moved down sampling needle 37 by Z-direction transmission mechanism 36
Point blood is carried out into RBC/PLT measurement modules 13 and starts RBC and PLT measurements.After complete component blood, sampling needle 37 passes in Z-direction
Elemental height is risen under the driving of motivation structure 36, while swab 38 cleans the outer wall of sampling needle 37.
Hemolytic agent is added in step 8, WBC/HGB measurement modules 12.Hemolytic agent is added WBC/HGB by fluid path support module 8
In measurement module 12, start WBC and HGB measurements.
Step 9, draw latex reagent.X-direction transmission device 33 drives travel(l)ing rest 34 to be moved to latex reagent storage mould
The top of block 5, sampling needle 37 is moved down into latex reagent memory module 5 by Z-direction transmission mechanism 36 and tries latex
Agent is drawn into sampling needle 37.Sampling needle 37 rises to elemental height, while swab 38 under the driving of Z-direction transmission mechanism 36
Clean the outer wall of sampling needle 37.
Step 10, latex reagent add CRP Measurement channels 1.X-direction transmission device 33 drives travel(l)ing rest 34 to be moved to C
The top of reactive protein measurement module 2, sampling needle 37 is moved down into CRP Measurement channels 1 by Z-direction transmission mechanism 36 will
Latex reagent is added thereto, while starts CRP measurements.
Step 11, cleaning WBC category measurements module 11, WBC/HGB measurement modules 12 and RBC/PLT measurement modules 13.
After WBC category measurements module 11, WBC/HGB measurement modules 12 and RBC/PLT measurement modules 13 complete 1 each measurement of sample, liquid
Reagent is transported in corresponding measurement module and completes to clean by road support module 8.
Step 12, the auto injection of sample 2 and mixing, sample 2 are drawn.Repeat step 1 and step 2, handle sample 2.
CRP hemolytic agents are added in step 13, CRP Measurement channels 2.Fluid path support module 8 provides power, by CRP hemolytic agents
Add in the CRP Measurement channels 2 of c reactive protein measurement module 2.
Step 14, CRP Measurement channels 2 divide blood.It is logical that X-direction transmission device 33 drives travel(l)ing rest 34 to be moved to CRP measurements
Sampling needle 37, is moved down into CRP Measurement channels 2 by the top of road 2 by Z-direction transmission mechanism 36, is added needed for CRP measurements
Blood sample.Blood sample starts sample haemolysis after adding CRP Measurement channels 2, is ready for follow-up CRP measurements.Sampling needle 37 is in Z
Direction transmission mechanism 36 rises to elemental height under driving, while swab 38 cleans the outer wall of sampling needle 37.
Step 15, the measurement of the blood routine of sample 2, draw latex reagent.Repeat step 5 is to step 9.
Step 16, latex reagent add CRP Measurement channels 2.X-direction transmission device 33 drives travel(l)ing rest 34 to be moved to C
The top of reactive protein measurement module 2, sampling needle 37 is moved down into CRP Measurement channels 2 by Z-direction transmission mechanism 36 will
Latex reagent is added thereto, while starts CRP measurements.
Step 17, cleaning WBC category measurements module 11, WBC/HGB measurement modules 12 and RBC/PLT measurement modules 13.
After completing the measurement of the blood routine of sample 2, repeat step 11.
Step 18, cleaning c reactive protein measurement module 2.Because CRP time of measuring is compared with blood routine time of measuring length, waiting
Blood routine to sample 2 is completed after measuring, and the sample 1 in CRP passages 1 completes CRP measurements, and now fluid path support module 8 starts
The cleaning of CRP Measurement channels 1.Pass through 1 minute again, treat that CRP Measurement channels 2 complete the measurement of sample 2, fluid path support module 8 opens
The cleaning of dynamic CRP Measurement channels 2.
So far, the measurement of the respective whole blood sample blood routine parameter of continuous two samples and CRP parameters is completed.
Use above specific case is illustrated to the application, is only intended to help and is understood the application not limiting
The application.For those of ordinary skill in the art, according to the thought of the application, above-mentioned embodiment can be become
Change.
Claims (17)
- A kind of 1. blood detector, it is characterised in that including:C reactive protein measurement module, for providing measurement place for allocated sample, allocated sample is carried out to obtain Measurement for the purpose of c reactive protein parameter simultaneously exports measurement result, and it is logical that the c reactive protein measurement module includes multiple measurements Road, each Measurement channel transports pipeline including reaction vessel, measurement container, hemolytic agent and sample transports pipeline, and the reaction is held Device transports pipeline by sample with measurement container and controllably connected, and hemolytic agent transports pipeline and is used to hemolytic agent adding reaction vessel In;Sample collection and distribute module, c reactive protein measurement is distributed to for gathering whole blood sample, and by the whole blood sample of collection Multiple Measurement channels of module;Fluid path support module, fluid path is provided and supported for sample collection and distribute module and each measurement module;Control and message processing module, are respectively coupled to sample collection and distribute module, c reactive protein measurement module and fluid path branch Module is held, for controlling sample collection and distribute module to gather whole blood sample and distribution whole blood sample, control fluid path support module Fluid conveying is carried out, the measurement result of c reactive protein measurement module output is received and measurement result is handled;Connect in sample During continuous measurement, the control and message processing module control the sample collection and distribute module collection whole blood sample, and will adopt The whole blood sample of collection is according to the default reaction vessel for being sequentially assigned to a Measurement channel in turn, the control and information processing Module also controls the fluid path support module to provide power, and hemolytic agent is transported into pipeline by the hemolytic agent adds the reaction In container, the hemolytic agent is reacted with the whole blood sample and latex reagent added later in the reaction vessel, then Pipeline is transported by the sample sample that reaction vessel exports is transported in measurement container, the control and information processing mould Block controls sample collection to start next whole blood sample with distribute module when current sample does not complete c reactive protein parameter measurement Collection and distribution, by the whole blood sample of collection according to predetermined amount distribute to c reactive protein measurement module another measurement Passage, making c reactive protein measurement module, existence time overlaps at least in the measurement process to two distribution samples.
- A kind of 2. blood detector, it is characterised in that including:C reactive protein measurement module, for providing measurement place for allocated sample, allocated sample is carried out to obtain Measurement for the purpose of c reactive protein parameter simultaneously exports measurement result, the c reactive protein measurement module include a reaction vessel, At least one measurement container, sample transport pipeline and hemolytic agent transports pipeline, and the hemolytic agent transports pipeline and is used for hemolytic agent Add in the reaction vessel, the reaction vessel is used for the whole blood sample and latex for receiving sample collection and distribute module distribution Reagent, the reaction vessel transport pipeline by sample with measurement container and controllably connected, and measurement container is used to carry for reaction solution For measuring place;Sample collection and distribute module, c reactive protein measurement is distributed to for gathering whole blood sample, and by the whole blood sample of collection Reaction vessel in module;Fluid path support module, fluid path is provided and supported for sample collection and distribute module and c reactive protein measurement module;Control and message processing module, are respectively coupled to sample collection and distribute module, c reactive protein measurement module and fluid path branch Module is held, for controlling sample collection and distribute module to gather whole blood sample and distribution whole blood sample, control fluid path support module Fluid conveying is carried out, the measurement result of c reactive protein measurement module output is received and measurement result is handled;Connect in sample During continuous measurement, the control and message processing module control sample collection and distribute module collection whole blood sample, and by collection Whole blood sample distributes to the reaction vessel in c reactive protein measurement module, and the control and message processing module also control fluid path Support module provides power, and hemolytic agent is transported into pipeline by hemolytic agent adds in reaction vessel, and the hemolytic agent with adding later The whole blood sample and latex reagent entered is reacted in reaction vessel, and then transporting pipeline by sample exports reaction vessel Sample be transported to measurement container in.
- 3. blood detector as claimed in claim 2, it is characterised in that the control and message processing module react egg in C Sample collection is controlled to start with distribute module when white measurement module does not complete the c reactive protein parameter measurement of current sample next The collection and distribution of whole blood sample, next whole blood sample of collection is distributed into the reaction in the c reactive protein measurement module Container.
- 4. blood detector as claimed in claim 3, it is characterised in that the c reactive protein measurement module includes multiple surveys Container is measured, when sample continuously measures, pipeline is transported by the sample that reaction vessel exports according to default suitable in turn by sample Sequence is transported to one in multiple measurement containers, and the control and message processing module do not complete c reactive protein in current sample Control sample collection to start the collection and distribution of next sample with distribute module during parameter measurement, the whole blood sample of collection is pressed The reaction vessel of c reactive protein measurement module is distributed to according to predetermined amount, makes c reactive protein measurement module at least to two points Existence time overlaps in measurement process with sample.
- 5. such as the blood detector any one of claim 1-4, it is characterised in that c reactive protein measurement module also wraps CRP measuring cell waste liquid output mechanisms and reaction tank waste liquid output mechanism are included, CRP measuring cell waste liquid output mechanisms and measurement container connect Logical, for discharging the waste liquid measured in container, reaction tank waste liquid output mechanism connects with reaction vessel, for discharging reaction vessel In waste liquid.
- 6. blood detector as claimed in claim 5, it is characterised in that the reaction vessel complete operation after, control and Message processing module control fluid path support module drives the waste liquid in the reaction vessel to be discharged by reaction tank waste liquid output mechanism; And/or after the measurement container completes operation, control and message processing module control fluid path support module drive the measurement Waste liquid in container is discharged by the measurement CRP measuring cell waste liquids output mechanism.
- 7. blood detector as claimed in claim 6, it is characterised in that the reaction vessel complete operation after and the survey When amount container does not complete the c reactive protein parameter measurement of current sample, control and message processing module control fluid path to support mould Block drives the waste liquid in the reaction vessel to be discharged by reaction tank waste liquid output mechanism;And/or complete behaviour in the measurement container After work and when the reaction vessel does not complete the reaction of next whole blood sample, control and message processing module control fluid path branch The waste liquid measured described in module drive in container is held to be discharged by the measurement CRP measuring cell waste liquids output mechanism.
- 8. the blood detector as described in claim any one of 1-7, it is characterised in that the fluid path support module is additionally operable to Current sample cleans the reaction vessel when not completing c reactive protein parameter measurement, so as to the sample collection and distribute module Next whole blood sample of collection is distributed into the reaction vessel.
- 9. the blood detector as described in claim any one of 1-7, it is characterised in that the fluid path support module is used to work as Preceding sample cleans the measurement container after completing c reactive protein parameter measurement, so that next sample of reaction vessel output enters The measurement container.
- 10. blood detector as claimed in claim 1 or 2, it is characterised in that the c reactive protein measurement module also includes One detection means, the detection means include light transmitting terminal and light test side, and the smooth transmitting terminal, which is used for transmitting, can irradiate measurement The light of container, the smooth test side are used for the light for receiving measured container.
- 11. blood detector as claimed in claim 1 or 2, it is characterised in that described automatic also including auto injection module Sample introduction module provides continuous sample for sample collection and distribute module automatically and completes sample and loads and unload, the auto injection Module is arranged on the front end of blood detector.
- 12. blood detector as claimed in claim 1 or 2, it is characterised in that the sample collection includes moving with distribute module Motivation structure and the sampling needle being fixed in travel mechanism, travel mechanism drive sampling needle to be moved in the horizontal direction with vertical direction.
- 13. blood detector as claimed in claim 1 or 2, it is characterised in that described also including latex reagent memory module Latex reagent memory module is used to provide Cord blood environment for latex reagent, and the latex reagent memory module is arranged on blood Detector closer to detector edge and away from internal position.
- 14. blood detector as claimed in claim 1 or 2, it is characterised in that described also including latex reagent memory module Latex reagent memory module is used to provide Cord blood environment for latex reagent, and the latex reagent memory module is arranged on automatically Between sample loading area and sample the unloading area of sample introduction module.
- 15. the blood detector as described in claim 13 or 14, it is characterised in that the latex reagent memory module includes:Refrigeration mechanism, its inside have cool room, and side has opening;Leng Shimen, for the closing cool room at the lateral opening of cool room, set on cold house's door towards the one side of cool room Be equipped with latex reagent and place position, cold house's door can make under stress latex reagent place position expose outside measuring instrument or Latex reagent placement position is closed to cool room.
- 16. blood detector as claimed in claim 15, it is characterised in that cold house's door and refrigeration mechanism are split type knot Structure, cold house's door away from cool room and can be exposed outside measuring instrument or by measuring instrument by way of push-and-pull and/or upset Outside close cool room simultaneously closes cool room.
- 17. blood detector as claimed in claim 1 or 2, it is characterised in that the control and message processing module control sample This collection, when the reaction tank into c reactive protein measurement module distributes sample, first stretches the pin hole of sampling needle with distribute module Under the liquid level for entering bottom liquid, then whole blood sample is injected into bottom liquid.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710876252.4A CN107656068B (en) | 2014-07-01 | 2014-07-01 | Blood detector |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CN2014/081426 WO2016000216A1 (en) | 2014-07-01 | 2014-07-01 | Whole blood sample testing method and blood tester |
CN201710876252.4A CN107656068B (en) | 2014-07-01 | 2014-07-01 | Blood detector |
CN201480039632.7A CN105378478B (en) | 2014-07-01 | 2014-07-01 | A kind of whole blood sample detection method and blood detector |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201480039632.7A Division CN105378478B (en) | 2014-07-01 | 2014-07-01 | A kind of whole blood sample detection method and blood detector |
Publications (2)
Publication Number | Publication Date |
---|---|
CN107656068A true CN107656068A (en) | 2018-02-02 |
CN107656068B CN107656068B (en) | 2020-06-09 |
Family
ID=55018296
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202110296868.0A Active CN113176417B (en) | 2014-07-01 | 2014-07-01 | Method for detecting blood conventional parameters and C-reactive protein parameters in blood sample |
CN201710876252.4A Active CN107656068B (en) | 2014-07-01 | 2014-07-01 | Blood detector |
CN201480039632.7A Active CN105378478B (en) | 2014-07-01 | 2014-07-01 | A kind of whole blood sample detection method and blood detector |
CN201710877017.9A Active CN107656085B (en) | 2014-07-01 | 2014-07-01 | Blood detector |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202110296868.0A Active CN113176417B (en) | 2014-07-01 | 2014-07-01 | Method for detecting blood conventional parameters and C-reactive protein parameters in blood sample |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201480039632.7A Active CN105378478B (en) | 2014-07-01 | 2014-07-01 | A kind of whole blood sample detection method and blood detector |
CN201710877017.9A Active CN107656085B (en) | 2014-07-01 | 2014-07-01 | Blood detector |
Country Status (2)
Country | Link |
---|---|
CN (4) | CN113176417B (en) |
WO (1) | WO2016000216A1 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110133244A (en) * | 2018-02-08 | 2019-08-16 | 成都深迈瑞医疗电子技术研究院有限公司 | A kind of chemical illumination immunity analysis instrument, its aspirating needle mechanism and cleaning method |
CN110346574A (en) * | 2018-04-08 | 2019-10-18 | 深圳市帝迈生物技术有限公司 | Method, blood analyzing apparatus and the device of Protein Detection device multiplexing detection albumen |
CN110579613A (en) * | 2019-10-28 | 2019-12-17 | 深圳开立生物医疗科技股份有限公司 | Blood analyzer |
WO2020155388A1 (en) * | 2019-02-02 | 2020-08-06 | 深圳迎凯生物科技有限公司 | Liquid distribution method and immunoassay method |
CN114689831A (en) * | 2020-12-31 | 2022-07-01 | 中元汇吉生物技术股份有限公司 | Blood analyzer and blood analysis method |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105784571B (en) * | 2016-02-29 | 2023-05-26 | 深圳市帝迈生物技术有限公司 | Double-pool measuring method and device for specific reaction protein CRP |
CN107063768B (en) * | 2017-06-14 | 2023-12-22 | 深圳市傲天医疗智能系统有限公司 | Blood sampling equipment and control method thereof |
CN109521214A (en) * | 2017-09-20 | 2019-03-26 | 深圳迈瑞生物医疗电子股份有限公司 | Automatic analyzer and its specimen needle or the working method of reagent needle, purge chamber |
CN108732135A (en) * | 2017-11-20 | 2018-11-02 | 重庆中元汇吉生物技术有限公司 | A kind of blood cell and analysis of protein device |
CN108443318B (en) * | 2018-03-13 | 2023-10-31 | 桂林优利特医疗电子有限公司 | Sampling mechanism of blood detecting instrument |
CN110346573A (en) * | 2018-04-08 | 2019-10-18 | 深圳市帝迈生物技术有限公司 | Blood analyzing apparatus |
LU100795B1 (en) | 2018-05-14 | 2019-11-14 | Diatron MI PLC | Immunoassay for whole blood samples |
CN109342749A (en) * | 2018-11-16 | 2019-02-15 | 陈大为 | A kind of blood routine kit and full-automatic Hematometer for integrating the detection of blood iodine |
CN111521773B (en) * | 2019-02-02 | 2021-09-14 | 深圳迎凯生物科技有限公司 | Liquid dispensing method and immunoassay method |
CN109932519A (en) * | 2019-04-19 | 2019-06-25 | 深圳市理邦精密仪器股份有限公司 | Blood test device |
CN112151163A (en) * | 2019-06-28 | 2020-12-29 | 深圳迈瑞生物医疗电子股份有限公司 | Method, device and system for setting sample priority |
CN112881703A (en) * | 2019-11-30 | 2021-06-01 | 深圳市帝迈生物技术有限公司 | Blood detection device and method and computer storage medium |
CN112881702B (en) * | 2019-11-30 | 2022-11-18 | 深圳市帝迈生物技术有限公司 | Blood detection device and method and computer storage medium |
CN113466473A (en) * | 2020-03-31 | 2021-10-01 | 深圳市帝迈生物技术有限公司 | Sample analyzer and sample analysis method and system |
CN113466474A (en) * | 2020-03-31 | 2021-10-01 | 深圳市帝迈生物技术有限公司 | Sample analyzer and sample analysis method and system |
CN113777332A (en) * | 2020-06-09 | 2021-12-10 | 深圳迈瑞生物医疗电子股份有限公司 | Immunoassay instrument and autoimmune analysis method |
CN114062694B (en) * | 2020-07-31 | 2022-12-06 | 深圳市帝迈生物技术有限公司 | Blood analysis method, blood analysis apparatus, and computer-readable storage medium |
CN114062036B (en) * | 2020-07-31 | 2023-12-29 | 深圳市帝迈生物技术有限公司 | Blood sample distribution method, blood detection device, and computer-readable storage medium |
CN113959992B (en) * | 2021-10-20 | 2023-07-18 | 深圳市科曼医疗设备有限公司 | Whole blood detection analysis system and whole blood sample detection method |
CN117460957A (en) * | 2021-12-28 | 2024-01-26 | 深圳迈瑞动物医疗科技股份有限公司 | Multifunctional sample analysis equipment |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6106778A (en) * | 1997-09-27 | 2000-08-22 | Horiba, Ltd. | Blood cell count/immunoassay apparatus using whole blood |
US20090142844A1 (en) * | 2005-07-08 | 2009-06-04 | Horiba Abx Sas | Automatic Method of Preparing Samples of Total Blood For Analysis, and an Automatic Device For Implementing the Method |
EP2136210A1 (en) * | 2008-06-18 | 2009-12-23 | Horiba, Ltd. | Body fluid sample analyzer |
CN101680876A (en) * | 2007-03-22 | 2010-03-24 | 商诊疗有限公司 | Whole blood assay |
CN102419367A (en) * | 2010-09-24 | 2012-04-18 | 株式会社堀场制作所 | Whole blood immunity measuring device and whole blood immunity measuring method |
CN103336130A (en) * | 2013-06-21 | 2013-10-02 | 嘉善加斯戴克医疗器械有限公司 | Whole-blood immunoassay device and blood analyzer with same |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE46998B1 (en) * | 1977-06-20 | 1983-11-30 | Coulter Electronics | Apparatus for monitoring chemical reactions and employing moving photometer means |
JP2761385B2 (en) * | 1988-04-08 | 1998-06-04 | 東亜医用電子株式会社 | Immunoagglutination measuring device |
JP3001082B2 (en) * | 1994-04-07 | 2000-01-17 | 株式会社日立製作所 | Automatic analyzer and method |
US6007775A (en) * | 1997-09-26 | 1999-12-28 | University Of Washington | Multiple analyte diffusion based chemical sensor |
JP2003315348A (en) * | 2002-04-22 | 2003-11-06 | Hitachi High-Technologies Corp | Specimen processing system and specimen inspection automating system using it |
JP2007093310A (en) * | 2005-09-27 | 2007-04-12 | Horiba Ltd | Sample analyzer |
CA3022666C (en) * | 2007-07-17 | 2022-04-19 | Somalogic, Inc. | Multiplexed analyses of test samples |
JP2009276214A (en) * | 2008-05-15 | 2009-11-26 | Hitachi High-Technologies Corp | Immuno-analyzer |
CN101762585A (en) * | 2009-05-05 | 2010-06-30 | 孔兵 | Cell morphology microscopic examination device and method based on staining technology |
EP2453224A4 (en) * | 2009-07-10 | 2015-05-27 | Hitachi High Tech Corp | Automatic analyzer |
CN201773103U (en) * | 2010-08-23 | 2011-03-23 | 重庆三峡中心医院 | Comprehensive postoperative infection prediction unit for children |
JP5588336B2 (en) * | 2010-12-17 | 2014-09-10 | 株式会社堀場製作所 | Blood analyzer and blood analysis method |
DE102011075762A1 (en) * | 2011-05-12 | 2012-11-15 | Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG | Analyzer for the automated determination of a measured variable of a measuring liquid |
CN102288745B (en) * | 2011-07-01 | 2013-08-14 | 深圳市麦迪聪医疗电子有限公司 | Method for controlling channel allocation of multi-channel biochemical analyzer |
JP6027742B2 (en) * | 2011-12-28 | 2016-11-16 | シスメックス株式会社 | Blood cell analyzer, blood cell analysis method, and computer program |
FR2986617B1 (en) * | 2012-02-02 | 2015-03-27 | Horiba Abx Sas | DEVICE AND METHOD FOR PERFORMING HEMATOLOGICAL AND BIOCHEMICAL MEASUREMENTS FROM A BIOLOGICAL SAMPLE |
CN102590539B (en) * | 2012-02-22 | 2013-12-11 | 漯河曙光汇知康生物科技有限公司 | Separated fully-automatic biochemical analyzer |
CN103293325A (en) * | 2012-03-01 | 2013-09-11 | 上海创石医学诊断产品有限公司 | Detection cell system for full-automatic C reaction protein detection instrument or full-automatic ultrasensitive C reaction protein analysis instrument |
CN102901835B (en) * | 2012-10-15 | 2014-01-29 | 山东美医林电子仪器有限公司 | Method and device for collecting sample by full-automatic blood cell analyzer |
JP5429416B2 (en) * | 2013-02-04 | 2014-02-26 | セイコーエプソン株式会社 | Inspection container, inspection device, and inspection method |
CN203432986U (en) * | 2013-07-05 | 2014-02-12 | 深圳普门科技有限公司 | Quasi-automatic in-vitro detection equipment for measuring specific proteins by turbidimetry |
-
2014
- 2014-07-01 CN CN202110296868.0A patent/CN113176417B/en active Active
- 2014-07-01 CN CN201710876252.4A patent/CN107656068B/en active Active
- 2014-07-01 WO PCT/CN2014/081426 patent/WO2016000216A1/en active Application Filing
- 2014-07-01 CN CN201480039632.7A patent/CN105378478B/en active Active
- 2014-07-01 CN CN201710877017.9A patent/CN107656085B/en active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6106778A (en) * | 1997-09-27 | 2000-08-22 | Horiba, Ltd. | Blood cell count/immunoassay apparatus using whole blood |
US20090142844A1 (en) * | 2005-07-08 | 2009-06-04 | Horiba Abx Sas | Automatic Method of Preparing Samples of Total Blood For Analysis, and an Automatic Device For Implementing the Method |
CN101680876A (en) * | 2007-03-22 | 2010-03-24 | 商诊疗有限公司 | Whole blood assay |
EP2136210A1 (en) * | 2008-06-18 | 2009-12-23 | Horiba, Ltd. | Body fluid sample analyzer |
CN102419367A (en) * | 2010-09-24 | 2012-04-18 | 株式会社堀场制作所 | Whole blood immunity measuring device and whole blood immunity measuring method |
CN103336130A (en) * | 2013-06-21 | 2013-10-02 | 嘉善加斯戴克医疗器械有限公司 | Whole-blood immunoassay device and blood analyzer with same |
Non-Patent Citations (1)
Title |
---|
INABA T: "Basic evaluation of Pentra MS CRP, a new automated hematology analyzer for rapid 5-part WBC differential and CRP using a small volume of whole blood", 《INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY》 * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110133244A (en) * | 2018-02-08 | 2019-08-16 | 成都深迈瑞医疗电子技术研究院有限公司 | A kind of chemical illumination immunity analysis instrument, its aspirating needle mechanism and cleaning method |
CN110346574A (en) * | 2018-04-08 | 2019-10-18 | 深圳市帝迈生物技术有限公司 | Method, blood analyzing apparatus and the device of Protein Detection device multiplexing detection albumen |
WO2020155388A1 (en) * | 2019-02-02 | 2020-08-06 | 深圳迎凯生物科技有限公司 | Liquid distribution method and immunoassay method |
CN110579613A (en) * | 2019-10-28 | 2019-12-17 | 深圳开立生物医疗科技股份有限公司 | Blood analyzer |
CN114689831A (en) * | 2020-12-31 | 2022-07-01 | 中元汇吉生物技术股份有限公司 | Blood analyzer and blood analysis method |
Also Published As
Publication number | Publication date |
---|---|
CN113176417A (en) | 2021-07-27 |
CN113176417B (en) | 2024-04-02 |
CN105378478B (en) | 2017-10-31 |
CN107656068B (en) | 2020-06-09 |
CN107656085B (en) | 2021-04-09 |
WO2016000216A1 (en) | 2016-01-07 |
CN107656085A (en) | 2018-02-02 |
CN105378478A (en) | 2016-03-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN105378478B (en) | A kind of whole blood sample detection method and blood detector | |
CN105572407B (en) | Full-automatic fluorescent quantitation immunity analysis instrument and detection method | |
US6106778A (en) | Blood cell count/immunoassay apparatus using whole blood | |
WO2018126774A1 (en) | Automatic analysis device and sample analysis method | |
CN106226541B (en) | A kind of automatic clinical chemistry analyzer of novel low cross contamination | |
CN108732135A (en) | A kind of blood cell and analysis of protein device | |
CN214953581U (en) | Biological sample joint inspection equipment | |
CN205656141U (en) | But conventional analytical equipment of simultaneous measurement CRP and blood | |
WO2018032718A1 (en) | Blood cell and biochemical assay device, and assay method thereof | |
CN116840499A (en) | Automatic analysis device and sample analysis method thereof | |
WO2019056233A1 (en) | Automatic analysis apparatus and operating method therefor | |
CN114019178A (en) | Full-automatic immune biochemical integrated analyzer and use method thereof | |
CN110095620A (en) | Specimen Determination system and Specimen Determination method | |
CN206020435U (en) | Hemocyte and bio-chemical detector | |
CN103575635B (en) | A kind of streaming instrument and its liquid-way system, method | |
CN113959992A (en) | Whole blood detection and analysis system and whole blood sample detection method | |
CN213580596U (en) | Sperm quality analysis's liquid way system and sperm quality analysis appearance | |
CN103344642A (en) | Full-automatic external detection equipment and method for measuring specific egg white by turbidimetry | |
CN212111455U (en) | Full-automatic immunoassay device based on turbidimetric detection | |
CN203432986U (en) | Quasi-automatic in-vitro detection equipment for measuring specific proteins by turbidimetry | |
CN115219442A (en) | Full-quantitative urine detection and analysis system and analysis method thereof | |
CN207650226U (en) | A kind of fast automatic biochemical detection system of application bar formula detection card | |
CN203432975U (en) | Full-automatic in-vitro detection equipment for measuring specific proteins by turbidimetry | |
US9606104B2 (en) | Automated platelet function analyzer and its analytical methods | |
CN112578121A (en) | Sample analyzer and sample detection method |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant |