CN107647847A - Sleep depth monitoring method and sleep depth monitor - Google Patents

Sleep depth monitoring method and sleep depth monitor Download PDF

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Publication number
CN107647847A
CN107647847A CN201610594910.6A CN201610594910A CN107647847A CN 107647847 A CN107647847 A CN 107647847A CN 201610594910 A CN201610594910 A CN 201610594910A CN 107647847 A CN107647847 A CN 107647847A
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brain
excited
region
electrical
driving
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CN201610594910.6A
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Chinese (zh)
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李小平
夏茜
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纽沃凯生物科技(深圳)有限公司
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Publication of CN107647847A publication Critical patent/CN107647847A/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/48Other medical applications
    • A61B5/4806Sleep evaluation
    • A61B5/4812Detecting sleep stages or cycles

Abstract

The invention provides a method and an instrument for measuring the sleep depth of the brain. According to the technical scheme, the measurement for the sleep depth of the brain is realized by detecting the inhibited degree of the nucleus ceruleus activation area during the transformation from the awakening state to the sound sleep state of the brain. The sleep depth of the brain is measured by detecting the inhibited degree of the nucleus ceruleus activation area of the brain during the transformation from the awakening state to the sound sleep state of the brain. The measurement method comprises the following steps: 1, directly detecting the inhibited degree of nucleus ceruleus activation area; 2, detecting the reduction of the strength of drive electric signals or standby electric signals sent by a brain drive activation area and passing through the drive nerve, thus the inhibited degree of nucleus ceruleus activation area is detected; and 3, detecting the reduction of the strengthof electric signals or standby electric signals sent by the brain drive activation area and received by any piece of muscle of the body, and thus the inhibited degree of the nucleus ceruleus activation area is detected.

Description

睡眠深度监测方法和睡眠深度监测仪 Depth of sleep monitoring methods and sleep depth monitor

技术领域 FIELD

[0001 ] 本发明提供测量睡眠深度的方法和仪器。 [0001] The present invention provides a measurement method and apparatus of the sleep depth.

背景技术 Background technique

[0002] 对睡眠深度的测量有多种重要用途,包括医生对病人身体状况的检查以及个人对自身睡眠质量的认知。 [0002] There are many important uses for measuring the depth of sleep, including medical examination and personal knowledge of the patient's physical condition on the quality of sleep itself. 目前,脑电仪能检测脑在打瞌睡的状态和脑的非梦眠的状态,但不能区分脑在醒的状态和在梦眠的状态;脑电仪(EEG)与眼电图(E0G)和肌电仪(EMG)并用能检测脑在梦眠的状态,但没任何方法和仪器能测量睡眠深度。 At present, the EEG instrument can detect a doze state in the brain and non-dream sleep state of the brain, but not differentiate in the brain in awake state and a sleep state of the dream; EEG instrument (EEG) and the electro-oculogram (E0G) and electromyography (EMG) and dried in the brain can detect the state of sleep dreams, but not any of the methods and apparatus capable of measuring the depth of sleep.

发明内容 SUMMARY

[0003] 脑有多个功能兴奋区。 [0003] There are multiple brain functions excitement district. 其中有驱动兴奋区、睡眠兴奋区、丘脑和蓝斑核兴奋区。 There driving excitement, sleeping excited zone, thalamus, and locus coeruleus excited area. 脑的驱动兴奋区任何时候都对全身的各块肌肉发送出驱动电信号或动作待机电信号。 Any time driving excitement district brain sends out electrical signals or drive operation standby electrical signal for each muscle of the body. 该驱动电信号或待机电信号先通过丘脑,然后通过蓝斑核兴奋区被驱动神经传动到身体的各块肌肉。 The drive by electrical or standby electrical signals to the hypothalamus, nerve transmission is then driven to various muscles of the body block by the locus coeruleus excited area. 当脑从醒的状态进入睡眠状态时,睡眠兴奋区提高兴奋致使睡眠荷尔蒙在全脑释放。 When the brain goes to sleep from waking, sleep excitement district improve sleep hormone release causes excitement in the whole brain. 睡眠荷尔蒙释放的结果导致1、全脑各个兴奋区的沟通/联系被阻隔;2、脑的蓝斑核兴奋区的兴奋频率降低以致降到零点,致使脑的驱动兴奋区对全身各块肌肉发出的驱动电信号或待机电信号在蓝斑核兴奋区被阻隔,减弱或根本发不出去。 The results lead to a sleep hormone release, communicating the excitement of each area of ​​the whole brain / contact is blocked; 2, locus coeruleus excited excitement frequency region of the brain that reduce down to zero, resulting in the drive area of ​​the brain excited issue for the whole body muscle the electrical drive or standby electrical signal is blocked in the locus coeruleus area excitability, reduced or simply unable to go. 当蓝斑核兴奋区被阻隔,大脑的的驱动电信号或待机电信号根本发不出去的时候,脑内各种脑神经递质的协调工作会使原先脑的各个兴奋区的被阻隔取消。 When the locus coeruleus excited area is blocked, the brain's electrical signals or standby electrical drive simply unable to go when the various brain neurotransmitters in the brain's coordination of the various causes excitement original area of ​​the brain is blocked canceled. 这时脑处于梦眠状态,也就是说当脑处于梦眠状态,蓝斑核兴奋区的兴奋降到最低/零点,这时脑驱动兴奋区对肌肉的驱动电信号或待机电信号不能发出到身体各块肌肉。 At this time the computer is in sleep dream state, that is when the brain is in a dream state of sleep, excitement locus coeruleus area excitability minimize / zero, then the area of ​​the brain drive the excitement of driving electrical muscle or standby electrical signals can not be sent to each body muscles.

[0004] 本发明提供一个测量脑的睡眠深度的方法和仪器。 [0004] The present invention provides a sleep depth measurement method and apparatus of the brain.

[0005] 在本发明中,对脑的睡眠深度的测量,是通过检测蓝斑核兴奋区被抑制的程度来实现的。 [0005] In the present invention, the sleep depth measured in the brain, is achieved by detecting the extent of the locus coeruleus excited region is suppressed.

[0006] 在本发明中,一个检测蓝斑核兴奋区被抑制的程度以测量脑的睡眠深度的方法是检测蓝斑核兴奋区的兴奋频率或强度。 [0006] In the present invention, a method of detecting the extent of the locus coeruleus excited region is suppressed to the sleep depth measured in the brain is excited frequency or intensity detecting locus coeruleus excited region. 该检测方法包括任何能够检测到蓝斑核兴奋区的兴奋频率或强度的方法,例如:脑电图(EEG,植入式或非植入式)、电磁波透视法、脑磁图(MEG)、功能核磁共振(fMRI)、正电子断层扫描(PET)。 The detection methods include any method capable of detecting the frequency or intensity of excitement locus ceruleus excited region, for example: electromagnetic waves perspective electroencephalogram (the EEG, implanted or implantable), magnetoencephalography (MEG), functional magnetic resonance imaging (fMRI), positron emission tomography (PET).

[0007] 在本发明中,另一个检测蓝斑核兴奋区被抑制的程度以测量脑的睡眠深度的方法是测量通过驱动神经的脑驱动兴奋区发出的电信号或待机电信号的强度下降程度来实现的。 Method [0007] In the present invention, the degree of excitement of the other detection locus coeruleus region is suppressed to measure the sleep depth is a measure of the brain's electrical driving level of strength is lowered or standby electrical signals emitted by the excited region of the brain nerve driving to achieve.

[0008] 在本发明中,另一个检测蓝斑核兴奋区被抑制的程度以测量脑的睡眠深度的方法是检测身体上任何一块肌肉所接收到的由脑驱动兴奋区发出的驱动电信号或待机电信号的强度随睡眠深度下降的程度。 Method [0008] In the present invention, the degree of excitement of the other detection locus coeruleus region is suppressed to measure the depth of sleep is detected in the brain of any muscle driving electrical signal received by the brain excitability driven body region emitted or standby electrical signal strength with the sleep depth extent of the decline.

附图说明 BRIEF DESCRIPTION

[0009] 图1显示脑的与本发明相关的四个兴奋区(驱动兴奋区、睡眠兴奋区、丘脑、蓝斑核兴奋区)在醒的状态下的相互关系。 [0009] FIG. 1 shows four of the present invention related to the excited region of the brain (driving excitement, sleeping excited region, hypothalamus, locus coeruleus excited region) in the relationship between the awake state.

[0010] 图2显示脑的与本发明相关的四个兴奋区(驱动兴奋区、睡眠兴奋区、丘脑、蓝斑核兴奋区)在由醒的状态转化到梦眠状态下的相互关系。 [0010] FIG. 2 shows four related to the present invention, the excitement region of the brain (driving excitement, sleeping excited region, hypothalamus, locus coeruleus excited region) in the awake state to the conversion relationship in the dream state of sleep.

[0011] 图3显示本发明的用电极针插入蓝斑核兴奋区直接检测蓝斑核兴奋区的被抑制的程度来测量脑的睡眠深度。 [0011] Figure 3 shows the extent of insertion locus coeruleus excited direct detection region locus ceruleus excited region of the needle electrode is suppressed according to the present invention, the sleep depth measured in the brain.

[0012] 图4显示本发明的用脑电仪检测头皮上的电位变化以检测蓝斑核兴奋区的被抑制的程度来测量脑的睡眠深度。 [0012] Figure 4 shows the change in the potential of the scalp EEG cytometry to detect the degree of the inhibition zone locus ceruleus excited sleep depth measured in the brain of the present invention.

[0013] 图5显示本发明的用电磁波检测蓝斑核兴奋区兴奋频率的变化以检测蓝斑核兴奋区的被抑制的程度来测量脑的睡眠深度。 [0013] Figure 5 shows detection of the electromagnetic wave excited region of the locus coeruleus of the present invention, the excitement of the frequency change is suppressed to the extent detected locus ceruleus excited region of the brain to measure the depth of sleep.

[0014] 图6显示本发明的用电极针插入驱动神经检测通过驱动神经的脑驱动兴奋区发出的驱动电信号或待机电信号强度的变化以检测蓝斑核兴奋区的被抑制的程度来测量脑的睡眠深度。 [0014] FIG. 6 shows a needle electrode inserted into the drive according to the present invention is detected by the brain nerve nerves driving driven changes excited region or electrical signals sent from a standby intensity is suppressed to the extent of the locus ceruleus excited region detected to measure deep sleep the brain.

[0015] 图7显示本发明的用脑电仪检测驱动神经附近皮肤的电位变化以检测通过驱动神经的脑驱动兴奋区发出的驱动电信号或待机电信号强度的变化以检测蓝斑核兴奋区的被抑制的程度来测量脑的睡眠深度。 [0015] Figure 7 shows the driving potential changes near the skin nerves EEG cytometry using the present invention to detect changes in an electrical signal by driving a driving brain nerve excitement driving region emitted intensity or electrical signals to detect a standby excited region locus coeruleus the degree of inhibition was used to measure the depth of sleep the brain.

[0016] 图8显示本发明的用电磁波检测通过驱动神经的脑驱动兴奋区发出的驱动电信号或待机电信号强度的变化以检测蓝斑核兴奋区的被抑制的程度来测量脑的睡眠深度。 [0016] Figure 8 shows the driving range excited region or electrical signals sent from a standby intensity is suppressed to the extent detected locus ceruleus excited region to the sleep depth measured brain waves detected by the present invention is driven by a driving brain nerve .

[0017] 图9显示本发明的用电极针插入身体任何一块肌肉以检测该肌肉所接收到的脑驱动兴奋区所发出的驱动电信号或待机电信号的强度的变化以检测蓝斑核兴奋区的被抑制的程度来测量脑的睡眠深度。 [0017] Figure 9 shows a needle electrode inserted into the body of the present invention to detect any change in muscle strength or standby electrical drive the electrical signals received by the brain muscle excitability driving region to detect the emitted excited region locus coeruleus the degree of inhibition was used to measure the depth of sleep the brain.

[0018] 图10显示本发明的用电极在身体任何一块肌肉的皮肤表面检测该肌肉所接收到的脑驱动兴奋区所发出的驱动电信号或待机电信号的强度的变化以检测蓝斑核兴奋区的被抑制的程度来测量脑的睡眠深度。 [0018] Figure 10 shows an electrode according to the present invention detects any muscle in the skin surface of the body varying intensity or standby electrical drive the electrical signals received by the brain muscle excitability driving region to detect the emitted excited locus coeruleus the degree of inhibition zone to measure the depth of sleep the brain.

[0019] 图11显示本发明的用两个或多个电极在身体任何一块肌肉的皮肤表面检测该肌肉所接收到的脑驱动兴奋区所发出的驱动电信号或待机电信号的强度的变化以检测蓝斑核兴奋区的被抑制的程度来测量脑的睡眠深度。 [0019] FIG. 11 shows two or more drive electrodes detect change in intensity of the electrical or standby electrical muscle received brain region emitted by excited driving surface of the skin of any one muscle in the body of the present invention the degree of inhibition was detected locus coeruleus excited area to measure the depth of sleep the brain.

[0020] 图12显示本发明的用电磁波检测身体任何一块肌肉所接收到的脑驱动兴奋区所发出的驱动电信号或待机电信号的强度的变化以检测蓝斑核兴奋区的被抑制的程度来测量脑的睡眠深度。 [0020] FIG. 12 shows the degree of change in the intensity of an electric signal driving an electrical or electromagnetic wave detector stand of the present invention any body brain muscle excitability received driving region to detect the emitted locus ceruleus excited region is suppressed to measure the depth of sleep the brain.

[0021] 图13显示本发明的如图11所示方法的检测四肢上任何一块肌肉所接收到的脑驱动兴奋区所发出的驱动电信号或待机电信号的强度的变化以检测蓝斑核兴奋区的被抑制的程度来测量脑的睡眠深度。 [0021] Figure 13 shows a muscle received any brain electrical driving range or driving strength standby electrical signals emitted by the excited region of the limbs detecting method shown in FIG. 11 of the present invention to detect the excited locus coeruleus the degree of inhibition zone to measure the depth of sleep the brain.

[0022] 图14显示本发明的如图11所示方法的检测脸上任何一块肌肉所接收到的脑驱动兴奋区所发出的驱动电信号或待机电信号的强度的变化以检测蓝斑核兴奋区的被抑制的程度来测量脑的睡眠深度。 [0022] FIG. 14 shows the change in intensity of the electric signal or standby electrical drive according to the present invention FIG face detecting method shown in any one muscle 11 received the driving excited brain region to detect the emitted excited locus coeruleus the degree of inhibition zone to measure the depth of sleep the brain.

[0023] 图15显示本发明的图11所示方法的检测手指或脚趾上任何一块肌肉所接收到的脑驱动兴奋区所发出的电信号或待机电信号的强度的变化以检测蓝斑核兴奋区的被抑制的程度来测量脑的睡眠深度。 [0023] Figure 15 shows muscle any one of the received strength of brain electrical driving range or standby electrical signals emitted by the excited region of the present invention, FIG detecting method shown fingers or toes 11 to detect the excited locus coeruleus the degree of inhibition zone to measure the depth of sleep the brain.

具体实施方式 Detailed ways

[0024] 如图1所示,脑1在醒的状态下,驱动兴奋区2将驱动电信号或待机电信号5先通过丘脑3,然后通过蓝斑核兴奋区4,继而通过驱动神经6,发送到身体任何一块肌肉8。 [0024] 1, 1 in the brain awake state, the driving of the driving electrical excitement region 2 or 5 to a standby electrical 3 by the hypothalamus, locus coeruleus and excited region through 4, in turn driven by a neural 6, send to any body muscle 8.

[0025] 如图2所示,脑1由醒的状态转化到熟睡状态时,睡眠兴奋区7提高兴奋,通过渠道9 释放睡眠荷尔蒙,抑制蓝斑核兴奋区4的兴奋,从而阻挡驱动电信号或待机电信号5通过蓝斑核兴奋区4,直至驱动神经6中的驱动电信号或待机电信号5减弱或趋于零。 [0025] As shown in FIG, 1 is transformed from the brain awake state to the sleep state, the sleep excited region 72 increase excitement, sleep hormones released through the channel 9, suppress excitement locus coeruleus excited region 4, thereby blocking the driving electrical signal or standby electrical signal 55 goes to zero or reduced by the locus coeruleus excited District 4, until the drive drive electrical nerve or standby electrical signal 6.

[0026] 在本发明中,脑的睡眠深度是指脑从醒的状态转变到熟睡状态的程度的度量,脑的睡眠深度的度量用蓝斑核兴奋区被抑制从而降低兴奋的降低百分比表示,例如,将睡眠深度分为〇到10级,当睡眠深度为零(脑处于醒的状态),蓝斑核兴奋区被抑制的程度为零(0% ),当睡眠深度为5级,蓝斑核兴奋区被抑制的程度为百分之五十(50% ),当睡眠深度为10级,蓝斑核兴奋区被抑制的程度为百分之百(1〇〇%)。 [0026] In the present invention, the sleep depth of the brain refers brain state transition from wake to sleep state measurement of the degree, brain sleep depth measurement with the locus ceruleus excited region is suppressed to reduce the excitability of the reduced percentage, For example, the sleep depth is divided into square to 10, when the sleep depth is zero (the brain in awake state), the extent of the locus coeruleus excited region is suppressed to zero (0%), when the sleep depth is 5, locus coeruleus the degree of inhibition of the nuclear region is excited to fifty percent (50%), when the sleep depth is 10, the extent of the locus coeruleus area excitability is suppressed to one hundred percent (1〇〇%).

[0027] 图3显示本发明的一个检测蓝斑核兴奋区4在脑1从醒的状态转到熟睡状态的过程中兴奋被抑制的程度以测量睡眠深度的方法和系统。 [0027] Figure 3 shows a detection locus coeruleus excited region 4 of the invention in the brain from a waking state to a degree of excitement is suppressed during sleeping state to a method and system measurement sleep depth. 其中,主要由电极针1〇和信号处理系统11组成检测蓝斑核兴奋区4兴奋强度的变化的系统以检测蓝斑核兴奋区4的被抑制的程度来测量脑1的睡眠深度。 Wherein, to the extent that the major excitatory detect locus coeruleus region 4 is inhibited brain sleep depth measured by the electrode pins 1 and the signal processing system 11 1〇 composition change system 4 detects the intensity of the excitement locus ceruleus excited region. 该方法中,将电极针1〇插入蓝斑核兴奋区4,直接检测蓝斑核兴奋区4的兴奋频率的变化,进而通过信号处理系统11来直接读取脑1的睡眠深度。 In this method, the electrode needle is inserted into the locus coeruleus 1〇 excited region 4, the frequency variation detected directly excited locus ceruleus excited region 4, and then 11 to read a sleep deep brain directly by the signal processing system.

[0028] 图4显示本发明的另一个检测蓝斑核兴奋区4在脑1从醒的状态转到熟睡状态的过程中兴奋被抑制的程度以测量睡眠深度的方法和系统。 [0028] FIG. 4 shows another detecting locus coeruleus excited region 4 of the invention in the brain from a waking state to a degree of excitement is suppressed during sleeping state to a method and system measurement sleep depth. 其中,主要由电极12和信号处理系统13组成的检测头皮14上的电位变化的系统以检测蓝斑核兴奋区4的被抑制的程度来测量脑1的睡眠深度。 Wherein the potential on the electrodes 12 and 14 mainly composed of a signal processing system 13 detects the level of the scalp in order to detect changes in system locus coeruleus excited region 4 is suppressed to the sleep depth measured brain 1. 该方法中,将电极12贴在头皮14上,检测头皮14上的电位变化,进而通过信号处理系统13来直接读取脑1的睡眠深度。 In this method, the electrode 12 is attached to the scalp 14, detecting a potential change on the scalp 14, 13 further reads a sleep deep brain directly by the signal processing system.

[0029] 图5显示本发明的另一个检测蓝斑核兴奋区4在脑1从醒的状态转到熟睡状态的过程中兴奋被抑制的程度以测量睡眠深度的方法和系统。 [0029] FIG. 5 shows another detection locus coeruleus excited region 4 of the invention in the brain from a state to the awake state of the sleeping process the degree of excitement is suppressed to a method and system measurement sleep depth. 其中,主要由电磁波信号发射和处理系统15、发射天线16、接受天线17组成的用电磁波透视蓝斑核兴奋区4的兴奋频率的变化的系统以检测蓝斑核兴奋区4的被抑制的程度来测量脑1的睡眠深度。 Wherein, mainly by electromagnetic signal transmission and processing system 15, transmitting antenna 16, the degree of change in beating frequency of the receiving antenna 17 composed of the electromagnetic wave perspective locus coeruleus excited region 4 a system for detecting the locus coeruleus excited region is suppressed 4 to measure the depth of sleep the brain 1. 该方法中,电磁波信号发射和处理系统15通过发射天线16发射电磁波,然后通过脑1的蓝斑核兴奋区4,最后由接收天线17接收并传回电磁波信号发射和处理系统15,电磁波信号发射和处理系统15将收到的信号与发出的信号比较,通过检测蓝斑核兴奋区4的兴奋频率的变化来检测蓝斑核兴奋区4的被抑制的程度从而测量脑1的睡眠深度。 In this method, the electromagnetic wave signal transmission and processing system 15 emitting an electromagnetic wave through the transmission antenna 16, then four, and finally received by the receiver antenna 17 through the brain locus coeruleus excited region 1 and the return electromagnetic signal transmission and processing system 15, an electromagnetic wave signal transmission and a signal processing system 15 is compared with the received signal sent to examine the extent of inhibition of the excited region of the locus ceruleus 4 by detecting changes in the excitement frequency excited locus ceruleus brain region 4 so that the sleep depth measured 1.

[0030] 图6显示本发明的另一个检测蓝斑核兴奋区4在脑1从醒的状态转到熟睡状态的过程中兴奋被抑制的程度以测量睡眠深度的方法和系统。 [0030] FIG 6 shows another detection locus coeruleus excited region 4 of the invention in the brain from a waking state to a degree of excitement is suppressed during sleeping state to a method and system measurement sleep depth. 其中,主要由电极针18和信号处理系统19组成的检测通过驱动神经6的脑驱动兴奋区2发出的驱动电信号或待机电信号5的强度的变化的系统以检测蓝斑核兴奋区4的被抑制的程度来测量脑的睡眠深度。 Wherein the detection electrode is mainly composed of needle 18 and the signal processing system 19 consisting of the drive system changes the intensity of the electrical drive 5 or standby electrical signal emitted by the excited region 2 6 brain neural drive to detect the excited region locus ceruleus 4 the degree of inhibition was measured sleep depth of the brain. 该方法中,将电极针18插入驱动神经6,检测通过驱动神经6的脑驱动兴奋区2发出的驱动电信号或待机电信号5的强度的变化,进而通过信号处理系统19来直接读取脑1的睡眠深度。 In this method, the needle electrode 18 is inserted into the nerve drive 6, detecting a change in intensity or standby electrical driving electrical signal emitted by excited region 2 5 6 driven by the brain nerve in the drive, and thus be read directly by the signal processing system 19 Brain sleep depth of 1.

[0031] 图7显示本发明的另一个检测蓝斑核兴奋区4在脑1从醒的状态转到熟睡状态的过程中兴奋被抑制的程度以测量睡眠深度的方法和系统。 [0031] FIG. 7 shows another detection locus coeruleus excited region 4 of the invention in the brain from a waking state to a degree of excitement is suppressed during sleeping state to a method and system measurement sleep depth. 其中,主要由电极20和信号处理系统21组成的检测驱动神经6附近的皮肤表面22的电位变化以检测通过驱动神经6的脑驱动兴奋区2发出的驱动电信号或待机电信号5的强度的变化的系统以检测蓝斑核兴奋区4的被抑制的程度来测量脑1的睡眠深度的。 Wherein the surface of the skin near the main electrode 20 and the signal processing system 21 consisting of 6 detection neural drive 22 to detect a potential change amplitude of the drive by electrical or standby electrical drive brain nerve excitement driving area 6 2 emitted 5 system to detect the degree of change in the locus coeruleus excited region 4 is suppressed to the sleep depth measured brain 1. 该方法中将电极2〇贴在驱动神经6附近的皮肤表面22 上,检测驱动神经6附近的皮肤表面22上的电位变化,进而通过信号处理系统21来直接读取脑1的睡眠深度。 This method will 2〇 electrodes attached to the skin surface of the drive 22 near the nerve to 6, detecting a potential change on the surface of the skin 22 near the nerve drive 6, thereby to read the sleep depth 21 directly through the brain a signal processing system.

[0032] 图8显示本发明的另一个检测蓝斑核兴奋区4在脑1从醒的状态转到熟睡状态的过程中兴奋被抑制的程度以测量睡眠深度的方法和系统。 [0032] FIG. 8 shows another detection locus coeruleus excited region 4 of the invention in the brain from a state to the awake state of the sleeping process the degree of excitement is suppressed to a method and system measurement sleep depth. 其中,主要由电磁波信号发射和处理系统23、发射天线24和接收天线25组成的用电磁波检测通过驱动神经6的脑驱动兴奋区2 发出的驱动电信号或待机电信号5的强度的变化的系统以检测蓝斑核兴奋区4的被抑制的程度来测量脑1的睡眠深度。 Wherein, mainly by electromagnetic signal transmission and processing system 23, transmitting antenna 24 and receiving antenna 25 composed of the electromagnetic wave intensity variation detected drive system 5 or standby electrical driving electrical signal emitted by the excited region 2 driving brain neural 6 to detect the extent of the locus coeruleus excited region 4 is suppressed to the sleep depth measured brain 1. 该方法中,电磁波信号发射和处理系统23通过发射天线料发射电磁波通过驱动神经6,然后由接收天线25接收并传回电磁波信号发射和处理系统23。 In this method, the electromagnetic wave signal transmission and processing system 23 through the transmitting antenna emits electromagnetic waves by driving the feed neural 6, then received by the receiving antenna 25 and return electromagnetic signal transmission and processing system 23. 电磁波信号发射和处理系统23将收到的信号与发出的信号比较,以检测通过驱动神经6的脑驱动兴奋区2发出的驱动电信号或待机电信号5强度的变化,进而检测蓝斑核兴奋区4的被抑制的程度来测量脑1的睡眠深度。 Transmitting an electromagnetic wave signal and the signal processing system 23 will receive the signal emitted by the comparison, or a standby driving electrical signal to an electrical signal by driving the detection drive excited region 6 Brains emitted intensity variation 25, thereby detecting the locus coeruleus excitement the degree of inhibition zone was measured sleep depth 4 of a brain.

[0033] 图9显示本发明的另一个检测蓝斑核兴奋区4在脑1从醒的状态转到熟睡状态的过程中兴奋被抑制的程度以测量睡眠深度的方法和系统。 [0033] FIG. 9 shows another detection locus coeruleus excited region 4 of the invention in the brain from a waking state to a degree of excitement is suppressed during sleeping state to a method and system measurement sleep depth. 其中,主要由电极针26和信号处理系统27组成的通过检测身体任何一块肌肉8所接收到的脑驱动兴奋区2所发出的驱动电信号或待机电信号5的的强度的变化的系统以检测蓝斑核兴奋区4的被抑制的程度来测量脑1 的睡眠深度。 Wherein an electrode needle 26 and the main signal processing system 27 by detecting the composition of any muscle of the body 8 to which the brain received the drive system of the change in intensity of 5 or standby electrical driving electrical signal emitted by excited regions 2 to detect the degree of suppression of the locus coeruleus was excited to measure the area of ​​the brain sleep depth 1 4. 该方法中,用电极针26插入身体任何一块肌肉8,检测该肌肉8所接收到的脑驱动兴奋区2所发出的驱动电信号或待机电信号5的强度的变化,进而通过信号处理系统W来直接读取脑1的睡眠深度。 In this method, a needle electrode 26 is inserted into the body 8 in any muscle, detecting a change in intensity the driving area of ​​the driving electrical excitement or two standby electrical signals emitted by the muscles 5 8 received the brain, and further by the signal processing system W to directly read brain sleep depth 1.

[0034] 图10显示本发明的另一个检测蓝斑核兴奋区4在脑1从醒的状态转到熟睡状态的过程中兴奋被抑制的程度以测量睡眠深度的方法和系统。 [0034] FIG. 10 shows another detection locus coeruleus excited region 4 of the invention in the brain from a waking state to a degree of excitement is suppressed during sleeping state to a method and system measurement sleep depth. 其中,主要由电极28和信号处理系统29组成的检测身体任何一块肌肉8上的皮肤表面30的电位变化以检测肌肉8所接收到的脑驱动兴奋区2所发出的驱动电信号或待机电信号5的强度的变化的系统来检测蓝斑核兴奋区4的被抑制的程度从而测量脑1的睡眠深度。 Wherein, on any skin surface mainly muscle electrodes 8 and 28 consisting of a signal processing system 29 detects a potential change of the body 30 to detect the received 8 muscle brain electrical or standby driving electrical signal emitted by the excited region 2 change in intensity of the system to detect the extent of 5 is inhibited excitement locus ceruleus brain region 4 so that the sleep depth measured 1. 该方法中,将电极狀贴在身体任何一块肌肉8上的皮肤表面30上,检测身体任何一块肌肉8上的皮肤表面3〇上的电位变化的强度随着肌肉8所接收到的脑驱动兴奋区2所发出的驱动电信号或待机电信号5的强度的变化,进而通过信号处理系统29来直接读取脑1的睡眠深度。 In this method, the electrode is attached to the shaped surface of the skin 30 on any one of the muscles of the body 8, the detection intensity potential changes on the skin surface 3〇 8 on the body with a muscle of any muscle eight received driving brain excitability change in intensity or a standby driving electrical signal emitted by an electrical signal region 2 5, and then 29 to read a sleep deep brain directly by the signal processing system.

[0035] 图11显示本发明的另一个检测蓝斑核兴奋区4在脑1从醒的状态转到熟睡状态的过程中兴奋被抑制的程度以测量睡眠深度的方法和系统。 [0035] FIG. 11 shows another detection locus coeruleus excited region 4 of the invention in the brain from a waking state to a degree of excitement is suppressed during sleeping state to a method and system measurement sleep depth. 其中,主要由两个或多个电极31 和信号处理系统32组成的检测身体任何一块肌肉8上的皮肤表面30的电位差的变化以检测肌肉8所接收到的脑驱动兴奋区2所发出的驱动电信号或待机电信号5的强度的变化的系统来检测蓝斑核兴奋区4的被抑制的程度从而测量脑1的睡眠深度。 Wherein, on any skin surface 8 consists of two main muscles or a plurality of electrodes 31 and 32 composed of a signal processing system for detecting the potential difference of the body 30 to detect changes in the received 8 muscle brain excitability driving emitted region 2 driving change in intensity of the electrical or standby electrical system 5 to detect the degree of inhibition is excited locus ceruleus brain region 4 so that the sleep depth measured 1. 该方法中,将两个或多个电极31贴在身体任何一块肌肉8上的皮肤表面30上,检测肌肉8上的皮肤表面3〇上的电位差变化的强度随着肌肉8所接收到的脑驱动兴奋区2所发出的驱动电信号或待机电信号5的强度的变化,进而通过信号处理系统32来直接读取脑1的睡眠深度。 In this method, two or more electrodes 31 on any skin surface of the body 8 a muscle 30, the potential difference detection intensity change on the skin surface 3〇 muscle with muscle 8 received 8 brain drive change in intensity of 5 or standby electrical driving electrical signal emitted by the excited region 2, and further reads a sleep deep brain directly by the signal processing system 32.

[0036] 图12显示本发明的另一个检测蓝斑核兴奋区4在脑1从醒的状态转到熟睡状态的过程中兴奋被抑制的程度以测量睡眠深度的方法和系统。 [0036] FIG. 12 shows another detection locus coeruleus excited region 4 of the invention in the brain from a waking state to a degree of excitement is suppressed during sleeping state to a method and system measurement sleep depth. 其中,主要由电磁波信号发射和处理系统33、发射天线34和接收天线35组成的用电磁波检测身体任何一块肌肉8所接收到的脑驱动兴奋区2所发出的驱动电信号或待机电信号5的强度的变化的系统来检测蓝斑核兴奋区4的被抑制的程度从而测量脑1的睡眠深度。 Wherein, mainly by electromagnetic signal transmission and processing system 33, transmitting antenna 34 and receiving antenna 35 composed of the electromagnetic wave detecting any muscle of the body 8 to the received electrical driving brain or standby electrical signals emitted by excited region 2 of 5 changing the system to detect the degree of intensity is inhibited excitement locus ceruleus brain region 4 so that the sleep depth measured 1. 该方法中,电磁波信号发射和处理系统33通过发射天线34发射电磁波通过身体任何一块肌肉8,然后由接收天线35接收并传回电磁波信号发射和处理系统33。 In this method, the electromagnetic wave signal transmission and processing system 33 through the transmitting antenna 34 emits electromagnetic waves through the body 8 in any muscle, is then received by the receiving antenna 35 and return electromagnetic signal transmission and processing system 33. 电磁波信号发射和处理系统33将收到的信号与发出的信号比较,以检测肌肉8所接收到的脑驱动兴奋区2所发出的驱动电信号或待机电信号5的强度的变化来检测蓝斑核兴奋区4的被抑制的程度从而测量脑1的睡眠深度。 Change in intensity of the emitted electromagnetic wave signal and a signal transmitting and signal processing system 33 to be received so as to detect the received eight muscle brain excitability drive region 2 emitted electrical or standby electrical drive to detect blue spot 5 the degree of excitement is suppressed nucleation region 4 so that the sleep depth measured brain 1.

[0037]图13显示本发明的另一个检测蓝斑核兴奋区4在脑1从醒的状态转到熟睡状态的过程中兴奋被抑制的程度以测量睡眠深度的方法和系统,主要由带子36、在带子上的电路板37(可以包含:两个或多个电极39、信号采集电路40、信号储存模块41、信号发射模块42、 系统控制模块43、电池44)、带子上的锁紧机构38组成的检测四肢上任何一块肌肉所接收到的脑驱动兴奋区2所发出的驱动电信号或待机电信号5的强度的变化的系统以检测蓝斑核兴奋区4的被抑制的程度来测量脑1的睡眠深度。 [0037] FIG. 13 shows a further level of detection locus coeruleus excited region 4 in the process of the present invention is to wake up the sleeping state from the state 1 in the brain is inhibited excitement in the sleep depth measurement method and system, mainly by the belt 36 a circuit board on the tape 37 (which may comprise: two or more electrodes 39, 40, the storage module 41 a signal, a signal transmission module 42, system control module 43, the signal acquisition circuit of the battery 44), the locking mechanism on the tape any muscle received intensity brain driving range or standby electrical driving electrical signal emitted by the excited region 2 5 38 composed of limbs detection system was inhibited to the extent of the locus ceruleus detected to measure excited region 4 1 of the depth of sleep the brain.

[0038]图14显示本发明的另一个检测蓝斑核兴奋区4在脑1从醒的状态转到熟睡状态的过程中兴奋被抑制的程度以测量睡眠深度的方法和系统,主要由贴片45、皮肤粘贴层61、在贴片上的电路板46(可以包含:两个或多个电极47、信号采集电路48、信号储存模块49、信号发射模块50、系统控制模块51、电池52)组成的检测脸上任何一块肌肉所接收到的脑驱动兴奋区2所发出的驱动电信号或待机电信号5的强度的变化的系统来检测蓝斑核兴奋区4的被抑制的程度来测量脑1的睡眠深度。 [0038] Figure 14 shows a further level of detection locus coeruleus excited region 4 in the process of the present invention is to wake up the sleeping state from the state 1 in the brain is inhibited excitement in the sleep depth measurement method and system, primarily by the patch 45, the skin adhesive layer 61, the patch 46 on the circuit board (may include: two or more electrodes 47, the signal acquisition circuit 48, the signal storage module 49, the signal transmitting module 50, system control module 51, the battery 52) composed of varying intensities detected face received any muscle brain excitability driving area of ​​the driving electrical or two standby electrical signals emitted by the system to detect the extent of 5 locus coeruleus excited region 4 is suppressed to measure brain sleep depth of 1.

[0039]图15显示本发明的另一个检测蓝斑核兴奋区4在脑1从醒的状态转到熟睡状态的过程中兴奋被抑制的程度以测量睡眠深度的方法和系统,主要由指环53、在指环上的电路板54 (可以包含:两个或多个电极55、信号米集电路56、信号储存模块57、信号发射模块58、 系统控制模块59、电池60)组成的检测手指上任何一块肌肉所接收到的脑驱动兴奋区2所发出的驱动电信号或待机电信号5的强度的变化的系统以检测蓝斑核兴奋区4的被抑制的程度来测量脑1的睡眠深度。 [0039] Figure 15 shows a further level of detection locus coeruleus excited region 4 in the process of the present invention is to wake up the sleeping state from the state 1 in the brain is inhibited excitement in the sleep depth measurement method and system, mainly by the ring 53 any finger on the detection composition: on the ring circuit board 54 (two or more electrodes 55, signal collection circuit 56 m, the storage module 57 a signal, a signal transmission module 58, system control module 59, the battery 60 may comprise a) muscle brain received the drive system changes the intensity of the electrical drive 5 or standby electrical signals emitted by excited regions 2 to detect the extent of the locus coeruleus excited region 4 is suppressed to the sleep depth measured brain 1.

[0040] 以上所述实施例的各技术特征可以进行任意的组合,为使描述简洁,未对上述实施例中的各个技术特征所有可能的组合都进行描述,然而,只要这些技术特征的组合不存在矛盾,都应当认为是本说明书记载的范围。 [0040] each of the above embodiments of the technical features of any combination can be, for the brevity, not each of the technical features of the embodiments described above are all the possible combinations will be described, however, as long as the combination of these features is not contradiction, they are to be considered in the scope described in this specification.

[0041] 以上所述实施例仅表达了本发明的几种实施方式,其描述较为具体和详细,但并不能因此而理解为对发明专利范围的限制。 [0041] The above embodiments are only expressed several embodiments of the present invention, and detailed description thereof is more specific, but can not therefore be understood to limit the scope of the invention. 应当指出的是,对于本领域的普通技术人员来说,在不脱离本发明构思的前提下,还可以做出若干变形和改进,这些都属于本发明的保护范围。 It should be noted that those of ordinary skill in the art, without departing from the spirit of the present invention, can make various changes and modifications, which fall within the protection scope of the present invention. 因此,本发明专利的保护范围应以所附权利要求为准。 Therefore, the protection scope of the present invention should be subject to the appended claims.

Claims (20)

  1. i .一种测量脑的睡眠深度的物理生理方法,通过检测脑的睡眠兴奋区对蓝斑核兴奋区的抑制程度来测量脑的睡眠深度,包括直接地检测蓝斑核兴奋区在脑从醒的状态转变到熟睡状态过程中被抑制的程度来测量脑的睡眠深度的方法,也包括间接地通过检测通过驱动神经的脑驱动兴奋区发出的驱动电信号或待机电信号的强度的降低以检测蓝斑核兴奋区在脑从醒的状态转变到熟睡状态过程中被抑制的程度来测量脑的睡眠深度的方法,也包括间接地通过检测身体任何一块肌肉所接收到的脑驱动兴奋区所发出的驱动电信号或待机电信号的强度的降低以检测蓝斑核兴奋区在脑从醒的状态转变到熟睡状态过程中被抑制的程度来测量脑的睡眠深度的方法。 i. kind of physical method physiological brain sleep depth measurement sleep depth measured by the degree of inhibition of brain excitability locus coeruleus regions excited by detecting a sleeping area of ​​the brain, including direct detection of the locus coeruleus in the brain is excited region awake the degree of the inhibition state to the sleeping state during the method of measuring the sleep depth of the brain, but also reduce the strength of the electrical drive or standby electrical signal indirectly emitted by the excited region detection drive driven by the brain to detect nerve the method of degree suppressed the locus ceruleus excited region in the brain transition from a state to wake up to the sleeping state during the measured sleep depth of the brain, but also indirectly any muscle received brain driving excited region by detecting body issued the method of the sleep depth of the extent of the brain is suppressed to reduce the drive strength of an electrical signal or an electrical signal to detect a standby locus ceruleus brain region excited state transition from the awake state to the sleeping process is measured.
  2. 2. 在权利要求1中,脑的睡眠深度是指脑从醒的状态转变到熟睡状态的程度的度量,脑的睡眠深度的度量用蓝斑核兴奋区被抑制从而降低兴奋的降低百分比表示,将睡眠深度分为若干级。 2. In claim 1, the sleep depth is meant the brain brain awake state transition from the sleeping state to a measure of the degree, the sleep depth measure brain locus ceruleus with excited region is suppressed to reduce the excitability of the percentage reduction, the depth of sleep is divided into several stages.
  3. 3. 在权利要求2中,睡眠深度分为0—10级,当睡眠深度为零(脑处于醒的状态),蓝斑核兴奋区被抑制的程度为零(〇%),当睡眠深度为5级,蓝斑核兴奋区被抑制的程度为百分之五十(50% ),当睡眠深度为10级,蓝斑核兴奋区被抑制的程度为百分之百(100%)。 3. In claim 2, the sleep depth is divided into a 0-10 scale, when the sleep depth is zero (the brain in awake state), the extent of the locus coeruleus excited region is suppressed to zero (square%), when the sleep depth is level 5, the extent of the locus coeruleus area excitability is suppressed for fifty percent (50%), when the sleep depth is 10, the extent of the locus coeruleus area excitability is suppressed to one hundred percent (100%).
  4. 4. 在权利要求1中,检测蓝斑核兴奋区被抑制的程度的方法是将电极针插入脑的蓝斑核兴奋区以测量蓝斑核兴奋区的电兴奋的变化,通过检测蓝斑核兴奋区的电兴奋的变化来检测蓝斑核兴奋区被抑制的程度,从而测量脑的睡眠深度。 4. In claim 1, the detection region of the locus coeruleus is inhibited excitement degree method is a needle electrode inserted into the locus ceruleus brain excitability regions to change the electrical excitement excited region locus coeruleus measured by detecting the locus coeruleus the excitement of change in the electrical excitability of the area to examine the extent of the locus coeruleus area excitability is suppressed, thereby measuring the depth of sleep the brain.
  5. 5. 在权利要求1中,检测蓝斑核兴奋区被抑制的程度的方法是将电极贴在头皮上测量头皮上电位随时间变化的变化以检测蓝斑核兴奋区的电兴奋的变化,进而检测蓝斑核兴奋区被抑制的程度,从而测量脑的睡眠深度。 5. In claim 1, the detection region of the locus coeruleus is inhibited excitement degree is to electrodes attached to the scalp on the scalp potential measuring a change over time to detect locus coeruleus excited electrically excited region changes, and further detecting the degree of locus coeruleus excited region is suppressed, so that the sleep depth measured in the brain.
  6. 6. 在权利要求1中,检测蓝斑核兴奋区被抑制的程度的方法是电磁波脑活动透视法,通过发射一定频率的电磁波穿过脑中的蓝斑核兴奋区,然后被接收并与穿透蓝斑核兴奋区前的电磁波比较以检测蓝斑核兴奋区兴奋频率的降低量,进而检测蓝斑核兴奋区被抑制的程度,从而测量到睡眠深度。 6. In claim 1, the detection region of the locus coeruleus is inhibited excitement degree is to brain wave activity perspective, certain frequency electromagnetic waves emitted by the brain through the excited region locus coeruleus, and then received through the wave front through the blue region of the nuclear excited spot to detect an excitatory excited locus coeruleus reduced amount of frequency, thereby detecting the extent of the locus coeruleus excited region is suppressed, so that the measured sleep depth.
  7. 7. 在权利要求1中,检测蓝斑核兴奋区被抑制的程度的方法是通过检测通过驱动神经的脑驱动兴奋区发出的驱动电信号或待机电信号的强度的降低以检测蓝斑核兴奋区的被抑制的程度,从而测量脑的睡眠深度。 7. In claim 1, the detection region of the locus coeruleus is inhibited excitement degree is to decrease the intensity of driving electrical drive or standby electrical signals emitted by the excited region of the brain is detected by detecting driving nerves excited locus coeruleus degree region is suppressed, so that the sleep depth measured in the brain.
  8. 8. 在权利要求7中,检测通过驱动神经的脑驱动兴奋区发出的驱动电信号或待机电信号的强度的降低的方法是将电极针插入任何的驱动神经以检测通过驱动神经的脑驱动兴奋区发出的驱动电信号或待机电信号的强度的降低量,以检测蓝斑核兴奋区被抑制的程度,从而测量脑的睡眠深度。 8. In claim 7, the drive method of detecting a decrease in strength or standby electrical drive electrical signals emitted by the excited region of the brain nerve drive is inserted into the needle electrode driving any nerves to the brain detected by driving the driving nerve excitement reducing the amount or intensity of the electrical signal drive region standby electrical signal emitted, to detect the extent of the locus coeruleus excited region is suppressed, so that the sleep depth measured in the brain.
  9. 9. 在权利要求7中,检测通过驱动神经的脑驱动兴奋区发出的驱动电信号或待机电信号的强度的降低的方法是将一个或多个电极贴在任何驱动神经附近的皮肤上,通过检测该驱动神经附近皮肤的电位变化以检测通过驱动神经的脑驱动兴奋区发出的驱动电信号或待机电信号强度的降低量以检测蓝斑核兴奋区的被抑制的程度,从而测量脑的睡眠深度。 9. In claim 7, the detection method of reducing the intensity of the electrical drive or standby electrical signals emitted by the excited region of the brain nerve drive is driven to one or more electrodes attached to the skin near the nerve any drive, by the driving potential variation detecting nerves near the skin to detect the electrical signals driving or reducing the intensity of the electrical signal emitted standby excited region is suppressed to the extent of the detection zone excited locus ceruleus, the brain to measure brain driven by nerve sleep depth.
  10. 10. 在权利要求7中,检测通过驱动神经的脑驱动兴奋区发出的驱动电信号或待机电信号的强度的降低的方法是电磁波透视法,通过发射一定频率的电磁波穿过任何驱动神经, 然后接收并与穿透驱动神经前的电磁波比较以检测通过驱动神经的脑驱动兴奋区发出的驱动电信号或待机电信号的强度的降低量,进而检测蓝斑核兴奋区被抑制的程度,从而测量脑的睡眠深度。 10. The method of reduced strength in claim 7, the detection zone excited by driving the driving brain nerve or standby driving electrical signal emitted electrical signal is an electromagnetic wave perspective, a certain frequency of electromagnetic waves emitted by any drive through nerves, and receiving the penetration drive and reduce the amount or intensity of the electrical signal driving wave front standby electrical nerve to detect an excited region driven by the driving brain nerve emitted, thereby detecting the extent of the locus coeruleus excited region is suppressed, so measuring deep sleep the brain.
  11. 11. 在权利要求1中,检测蓝斑核兴奋区被抑制的程度的方法是通过检测身体任何一块肌肉所接收到的脑驱动兴奋区所发出的驱动电信号或待机电信号的强度的降低以检测蓝斑核兴奋区的被抑制的程度,从而测量脑的睡眠深度。 11. The decrease in the strength of the electrical drive or standby electrical signals received by detecting any physical drive muscle excitability brain region emitted claim 1, the detection locus coeruleus excited region is suppressed to the degree of approach is detecting the degree of inhibition of the excited region of the locus ceruleus, the brain to measure the depth of sleep.
  12. 12. 在权利要求11中,检测身体任何一块肌肉所接收到的脑驱动兴奋区所发出的驱动电信号或待机电信号的的强度的降低的方法是将电极针插入身体任何一块肌肉以测量该肌肉所接收到的脑驱动兴奋区所发出的驱动电信号或待机电信号的强度的降低量以检测蓝斑核兴奋区的被抑制的程度,从而测量脑的睡眠深度。 12. A method of reducing the intensity of claim 11, detects any muscle of the body to the received electrical driving brain or standby electrical signals emitted by the excited region of the needle electrode is inserted into the body to measure the muscle of any reducing the amount of electrical or standby driving strength received electrical muscle brain excitability driving emitted region is suppressed to the extent of the detection zone excited locus ceruleus, the brain to measure the depth of sleep.
  13. 13. 在权利要求11中,检测身体任何一块肌肉所接收到的脑驱动兴奋区所发出的驱动电信号或待机电信号的强度的降低的方法是将一个或多个电极贴在身体任何一块肌肉附近的皮肤上,通过检测肌肉所接收到的脑驱动兴奋区所发出的驱动电信号或待机电信号的强度的降低量以检测蓝斑核兴奋区的被抑制的程度,从而测量脑的睡眠深度。 13. In claim 11, a method of reducing the intensity of the detected electrical driver or standby electrical signals emitted by excited region of the body received any muscle brain is driving a plurality of electrodes attached to the body or any muscle near the skin, received by detecting the amount of muscle strength decreased cerebral drive or standby electrical driving electrical signal emitted by excited region is suppressed to the extent of the detection zone excited locus ceruleus, the brain to measure the sleep depth .
  14. 14. 在权利要求11中,检测身体任何一块肌肉所接收到的脑驱动兴奋区所发出的驱动电信号或待机电信号的强度的降低的方法是电磁波透视法,通过发射一定频率的电磁波穿过身体任何一块肌肉,然后接收并与穿透肌肉前的电磁波比较以检测肌肉所接收到的脑驱动兴奋区所发出的驱动电信号或待机电信号的强度的降低量,进而检测蓝斑核兴奋区被抑制的程度,从而测量脑的睡眠深度。 14. The method as claimed in claim 11, detects any muscle of the body received the brain electrical drive driving a decrease in strength or standby electrical signals emitted by the excited region perspective electromagnetic wave, an electromagnetic wave passing through a certain frequency emitted by any muscle in the body, the penetration of electromagnetic waves and then receives the muscles before comparing the received detects muscle brain electrical drive to reduce the amount or intensity of the excited region of the standby electrical signal emitted by the drive, and thus the detection area locus coeruleus excitement degree is suppressed, so that the sleep depth measured in the brain.
  15. 15. 在权利要求7-14任意一项中,脑驱动兴奋区所发出的待机电信号是指驱动兴奋区对特定肌肉在不发出动作驱动电信号时保持与该肌肉的驱动联系所发出的联系电信号。 15. In any one of claims 7 to 14, the driving standby electrical brain excitability region emitted contact means maintaining the contact with the driving of the emitted muscle excited driving zone is not issued for a specific operation of the drive electrical muscle electric signal.
  16. 16. —种测量脑的睡眠深度的仪器,通过检测脑的睡眠兴奋区对蓝斑核兴奋区的抑制程度来测量脑的睡眠深度,其中,检测脑的睡眠兴奋区对蓝斑核兴奋区的抑制程度是通过检测身体任何一块肌肉所接收到的脑驱动兴奋区所发出的驱动电信号或待机电信号的强度的降低以检测蓝斑核兴奋区在脑从醒的状态转变到熟睡状态整个过程被抑制的程度来实现的;该仪器包括主要由一个或多个电极、信号采集电路、信号储存模块、信号发射模块、 系统控制模块、电池组成的电路和将电路贴附在肌肉附近的皮肤上的系统。 16. - kind of measuring instrument brain sleep depth measured sleep depth of the degree of inhibition of brain excitability locus coeruleus regions excited by detecting a sleeping area of ​​the brain, wherein the detection region of the brain excitatory sleeping excited region locus coeruleus the degree of inhibition is a reduction in the strength of the electrical drive or standby electrical signal emitted by excited region driven by any of a detecting body muscles to the brain in order to detect the received locus coeruleus regions excited state transition to a sleep whole process from the brain awake state the degree of inhibition was achieved; the apparatus includes a primary circuit of one or more components of the electrodes, the signal acquisition circuit, the signal storage module, a signal transmitter module, system control module, a battery and a circuit attached to the skin near the muscle system.
  17. 17. 在权利要求16中,一个或多个电极贴在四肢上任何一块肌肉附近的皮肤上,通过检测肌肉所接收到的脑驱动兴奋区所发出的驱动电信号或待机电信号的强度的降低量的系统是设有锁紧机构的带子,所述电路设置在带子上,通过检测身体任何一块肌肉所接收到的脑驱动兴奋区所发出的驱动电信号或待机电信号的强度的降低量以检测蓝斑核兴奋区的被抑制的程度,从而测量脑的睡眠深度。 17. In claim 16, the one or more electrodes attached to the limbs muscle near the skin with any received by detecting a decrease in strength of muscle brain driven or standby electrical driving electrical signal emitted by the excited region the system is provided with an amount of cord locking means, said circuit provided on the tape, any muscle received drive brain electrical drive strength decrease amount or standby electrical signals emitted by the excited region of the body to detect detecting the degree of inhibition of the excited region of the locus ceruleus, the brain to measure the depth of sleep.
  18. 18. 在权利要求16中,所述系统是肌肉贴片,主要由贴片、皮肤粘贴层组成,所述电路设置在贴片上,通过检测身体任何一块肌肉所接收到的脑驱动兴奋区所发出的驱动电信号或待机电信号的强度的降低量以检测蓝斑核兴奋区的被抑制的程度,从而测量脑的睡眠深度。 18. In claim 16, the system is a patch muscle, primarily by the patch, the skin adhesive layer, said circuit is provided on the patch, received by detecting any physical drive muscle brain excitability zone reduce the amount of strength or standby electrical driving electrical signal emitted is suppressed to the extent of the detection zone excited locus ceruleus, the brain to measure the depth of sleep.
  19. 19. 在权利要求16中,所述系统是指环,所述电路设置在指环上,通过检测手指或脚趾上任何一块肌肉所接收到的脑驱动兴奋区所发出的驱动电信号或待机电信号的强度的降低量以检测蓝斑核兴奋区的被抑制的程度,从而测量脑的睡眠深度。 19. In claim 16, the system is a ring, is provided on said circuit ring, received by any one finger or toe muscles detecting brain electrical or standby driving the electrical signals emitted by excited region reducing the amount of strength is suppressed to the extent of the detection zone excited locus ceruleus, the brain to measure the depth of sleep.
  20. 20. 在权利要求16-19任意一项中,所测量到的脑的睡眠深度是用任何图表记录并表现出来的,包括折线图、曲线图、条形图、柱形图、环状图、饼状图、立体图、散点图、组合图或面积图。 20. In any one of claims 16-19, the measured sleep depth is recorded and the brain manifested by any graph, including line graph, bar graph, bar graph, FIG ring, pie chart, a perspective, scatter, or a combination of the area of ​​FIG. FIG.
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Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190060658A1 (en) * 2017-08-26 2019-02-28 Xiaoping Li Method and apparatus of modulating a neuronal firing frequency at a brain functional site in a brain

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3951134A (en) * 1974-08-05 1976-04-20 Dorne & Margolin Inc. Apparatus and method for remotely monitoring and altering brain waves
US20110112427A1 (en) * 2009-11-12 2011-05-12 Neosync, Inc. Systems and methods for neuro-eeg synchronization therapy
CN102378596A (en) * 2009-04-02 2012-03-14 皇家飞利浦电子股份有限公司 Processing a bio-physiological signal
CA2821981A1 (en) * 2010-12-14 2012-06-21 The Regents Of The University Of California Devices, systems and methods for the treatment of medical disorders
CN102791332A (en) * 2009-11-04 2012-11-21 代理并代表亚利桑那州立大学的亚利桑那董事会 Devices and methods for modulating brain activity
CN103260506A (en) * 2010-10-29 2013-08-21 米卡·埃拉拉 A method and a device for measuring muscle signals
CN104080397A (en) * 2012-01-19 2014-10-01 脑科技医疗系统股份有限公司 Diagnostic system for detection of fluid changes
CN104814733A (en) * 2015-04-17 2015-08-05 中国人民解放军第二军医大学 Wearable and portable multi-guide sleeping monitoring system
CN105266802A (en) * 2014-07-20 2016-01-27 夏茜 Refreshing instrument

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1231206A (en) * 1998-08-31 1999-10-13 王树伯 Small radar abstinence apparatus
CN1245724A (en) * 1999-09-21 2000-03-01 郑明德 Therapeutic equipment for giving up drugs and abstinence
CN1248473A (en) * 1999-09-23 2000-03-29 唐健 Instrument for stopping drugs
US6477408B1 (en) * 2000-03-07 2002-11-05 Northwestern University Analysis of muscular activity in neonatal animals to screen for mutations and/or drugs that alter sleep and wake states
CN2511329Y (en) * 2001-08-03 2002-09-18 吴庆民 Therapeutical device for drug dependence
US8177702B2 (en) * 2004-04-15 2012-05-15 Neuronetics, Inc. Method and apparatus for determining the proximity of a TMS coil to a subject's head
US9743841B2 (en) * 2007-09-25 2017-08-29 Ric Investments, Llc Automated sleep phenotyping
WO2009094050A1 (en) * 2008-01-25 2009-07-30 Medtronic, Inc. Sleep stage detection
CN101569778B (en) * 2009-03-10 2011-06-22 深圳先进技术研究院 Biofeedback simulation system
US20110295142A1 (en) * 2010-05-25 2011-12-01 Neurowave Systems Inc. Detector for identifying physiological artifacts from physiological signals and method
WO2011158198A2 (en) * 2010-06-17 2011-12-22 Card Guard Scientific Survival Ltd. A method and a system for monitoring of sleep and other physiological conditions
EP2524647A1 (en) * 2011-05-18 2012-11-21 Alain Gilles Muzet System and method for determining sleep stages of a person
US20150230750A1 (en) * 2012-09-19 2015-08-20 Resmed Sensor Technologies Limited System and method for determining sleep stage
CN104873173A (en) * 2015-05-19 2015-09-02 上海兆观信息科技有限公司 Non-contact type sleep stage classification and sleep breathing disorder detection method

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3951134A (en) * 1974-08-05 1976-04-20 Dorne & Margolin Inc. Apparatus and method for remotely monitoring and altering brain waves
CN102378596A (en) * 2009-04-02 2012-03-14 皇家飞利浦电子股份有限公司 Processing a bio-physiological signal
CN102791332A (en) * 2009-11-04 2012-11-21 代理并代表亚利桑那州立大学的亚利桑那董事会 Devices and methods for modulating brain activity
US20110112427A1 (en) * 2009-11-12 2011-05-12 Neosync, Inc. Systems and methods for neuro-eeg synchronization therapy
CN103260506A (en) * 2010-10-29 2013-08-21 米卡·埃拉拉 A method and a device for measuring muscle signals
CA2821981A1 (en) * 2010-12-14 2012-06-21 The Regents Of The University Of California Devices, systems and methods for the treatment of medical disorders
CN104080397A (en) * 2012-01-19 2014-10-01 脑科技医疗系统股份有限公司 Diagnostic system for detection of fluid changes
CN105266802A (en) * 2014-07-20 2016-01-27 夏茜 Refreshing instrument
CN104814733A (en) * 2015-04-17 2015-08-05 中国人民解放军第二军医大学 Wearable and portable multi-guide sleeping monitoring system

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
卡尔森: "《行为生理学(第八版)》", 1 December 2014, 上海人民出版社 *

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