CN107582020A - A kind of ophthalmology imaging diagnosis system - Google Patents
A kind of ophthalmology imaging diagnosis system Download PDFInfo
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- CN107582020A CN107582020A CN201710991897.2A CN201710991897A CN107582020A CN 107582020 A CN107582020 A CN 107582020A CN 201710991897 A CN201710991897 A CN 201710991897A CN 107582020 A CN107582020 A CN 107582020A
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- 238000003745 diagnosis Methods 0.000 title claims abstract description 30
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Abstract
The invention discloses a kind of ophthalmology imaging diagnosis system, including ocular lens and OCT image module, OCT image module includes eyeground OCT image pattern and anterior ocular segment OCT image pattern；OCT image module has the first intermediate image plane in the OCT image pattern of eyeground, and the first intermediate image plane is between ocular lens and OCT image module；Lens group is set in the inside light path of the OCT image module of eyeground OCT image pattern, OCT image module has the second intermediate image plane, second intermediate image plane is located in OCT image module, the conjugate position of the imaging optical path aperture diaphragm of OCT image module obtains anterior ocular segment OCT image pattern between ocular lens and OCT image module.The ophthalmology imaging diagnosis system of the present invention has the function of realizing OCT fundus imagings and the imaging of OCT anterior ocular segments concurrently, and realizes the inside switching of the two.After fundus imaging is switched to anterior ocular segment imaging, increased second intermediary image in OCT image module newly, such a method light is incided the control of anterior ocular segment angle is more flexible, and anterior ocular segment visual field resolution ratio index can improve.The present invention is not influenceed using switching inside the light path of OCT image module in handoff procedure on other systems light path simultaneously.
Description
Technical field
The present invention relates to a kind of ophthalmology imaging diagnosis system.
Background technology
Optical coherent chromatographic imaging (OCT, Optical Coherence Tomography) technology, has high-resolution,
High image taking speed, the features such as not damaged, wherein the OCT devices for possessing ophthalmic diagnosis are OCT technology most widely one of application.
Refer to shown in Fig. 1, a kind of OCT light paths described in patent US8427654, particularly describe a kind of eyeground and
The switching method of anterior ocular segment imaging optical path.By moving into a lens group in OCT light paths, make the lens group focal plane close to eyes
Position, anterior ocular segment is moved to from internal system.Such a method advantage is that structure is relatively easy, but deposits anterior ocular segment visual field after handover
It is small, and anterior ocular segment light angle control it is dumb.
Refer to shown in Fig. 2, a kind of OCT systems for making eyes refraction index test are described in patent US20080106696A1
System, particularly contains the two kinds of imaging patterns in eyeground and anterior ocular segment.It is similar with patent US8427654, by being moved in OCT light paths
Enter a lens group, make the focusing position of focal plane of ocular lens annex, anterior ocular segment is moved to from internal system.
Refer to shown in Fig. 3,4 and 5, a kind of OCT systems and imaging method described in patent CN102438505ZHONG,
Also include a kind of anterior ocular segment and oculi posterior segment switching mode, by moving into a dichroscope, while will be close to the reflection of scanning mirror
Mirror is rotated by 90 ° direction, and anterior ocular segment light path is replaced into oculi posterior segment light path, accesses subsequent optical path acquisition system.Wherein, 1a1 dotted line sides
Frame is fundus imaging part, and 1b1 is dashed rectangle fundus imaging part.
Refer to shown in Fig. 6, a kind of OCT systems are described in patent US2008/0106696A1, in fundus imaging pattern
Under setting, by adding another ocular lens in former eye position annex, light path of the former conjugation to eyeground is switched to conjugation and arrive eye
Prosthomere.But such a method there is fixation light path can image quality it is impacted the problem of, for eyeball measurand, originally clearly
Fixation target can be thickened after anterior ocular segment is switched to.
In existing OCT markets, substantial portion of product covers anterior ocular segment and oculi posterior segment scan function simultaneously, and is directed to
The switching of anterior ocular segment imaging function and fundus imaging function is had nothing in common with each other mode.
Wherein, the outside switching mode such as patent US2008/0106696A1 persons of needing to use are manually operated, and convenience is poor,
And it is difficult to take into account interior fixation lamp；Some internal switching mode such as CN102438505ZHONG, are to rely on multi-disc plane reflection optics
Element, carry out the switching between two independent light paths；Also internal switching mode such as US8427654 and
US20080106696A1, by the way that system intermediate image plane is moved into mode at the moment, available fields are smaller, and are designed in this
Telecentric imaging is difficult to, limits the ability of systematic quantification measurement.
Therefore, it is necessary to which a kind of new ophthalmology imaging diagnosis system is to solve the above problems.
The content of the invention
To solve the defects of prior art is present, there is provided a kind of ophthalmology imaging diagnosis system.
In order to realize above-mentioned target, the present invention adopts the following technical scheme that：
A kind of ophthalmology imaging diagnosis system, including ocular lens and OCT image module, the OCT image module include eyeground
OCT image pattern and anterior ocular segment OCT image pattern；
OCT image module has the first intermediate image plane in the eyeground OCT image pattern, and first intermediate image plane is located at
Between ocular lens and the OCT image module；
Lens group, the OCT are set in the inside light path of the OCT image module of the eyeground OCT image pattern
Image-forming module has the second intermediate image plane, and second intermediate image plane is located in the OCT image module, the OCT image mould
The conjugate position of the imaging optical path aperture diaphragm of block between the ocular lens and OCT image module, obtain anterior ocular segment OCT into
As pattern.
Further, in addition to the first dichronic mirror, the OCT image module are arranged on the one of first dichronic mirror
Side, the ocular lens are arranged on the reflected light path of first dichronic mirror, and first intermediate image plane is located at the ocular lens
And first between dichronic mirror, the conjugate position of the imaging optical path aperture diaphragm of the OCT image module be located at the ocular lens and
Between first dichronic mirror.
Further, in the eyeground OCT image pattern and anterior ocular segment OCT image pattern of the OCT image module, eye
The light path ratio of bottom OCT image pattern and anterior ocular segment OCT image pattern meets following formula requirement：
In formula, OPLretinaRepresent optical path length under the pattern of eyeground, OPLcorneaRepresent optical path length under anterior ocular segment pattern.Adopt
With above-mentioned design OCT fundus imagings pattern can be ensured with the handoff procedure of anterior ocular segment imaging pattern, considering 24mm standard people
Under the premise of eye length, after being ensured before the handover by optical design, sample arm optical path length is approximate consistent.
Further, in addition to the second dichronic mirror and eyeground SLO scanning laser ophthalmoscope modules, second dichronic mirror
It is arranged on the transmitted light path or reflected light path of first dichronic mirror, the light between second dichronic mirror and the first dichronic mirror
The first relay is provided with road, the eyeground SLO scanning laser ophthalmoscope modules are arranged on the anti-of second dichronic mirror
Penetrate on light path or transmitted light path.
Further, in addition to the 3rd dichronic mirror, fixation target module and anterior ocular segment photographing module, the 3rd color separation
Mirror is arranged on the transmitted light path or reflected light path of second dichronic mirror, is set between the 3rd dichronic mirror and the second dichronic mirror
The second relay is equipped with, the fixation target module is arranged on the transmitted light path or reflected light path of the 3rd dichronic mirror,
The anterior ocular segment photographing module is arranged on the reflected light path or transmitted light path of the 3rd dichronic mirror.
Further, in addition to OCT galvanometers, the OCT galvanometers are arranged on the OCT image module away from described first
One end of dichronic mirror.
Further, the OCT image module includes the first lens group and the 3rd lens, and first lens group includes
First lens and the second lens, first lens are described away from the ocular lens close to the ocular lens, second lens
3rd lens are arranged on the side of first lens group away from the ocular lens.First lens and the second lens are respectively biconvex
Lens and meniscus shaped lens, can also be respectively biconvex positive lens and meniscus shaped lens.3rd lens are biconvex lens or bent moon
Shape lens.
Further, the lens group is arranged between second lens and the 3rd lens.
Further, the lens group includes the second lens group and the 3rd lens group, second lens group and the 3rd
Lens group is located at the both sides of second intermediate image plane respectively.
Further, second lens group includes the 4th lens, and the 3rd lens group includes the 5th lens and the
Six lens, the 5th lens and the 6th lens are successively away from second intermediate image plane.4th lens are planoconvex spotlight, the 5th
Lens are negative-power lenses, and the 6th lens are falcate positive lens.
Further, second lens group includes the two or four lens and the two or five lens, the two or four lens and
Two or five lens successively away from second intermediate image plane, the 3rd lens group include the two or six lens, the two or seven lens and
Two or eight lens, the two or six lens, the two or seven lens and the two or eight lens are successively away from second intermediate image plane.Its
In, specifically, the two or four lens 24 and the two or five lens 25 are meniscus shaped lens, and the face center of circle is close to anterior ocular segment imaging mould
Intermediate image plane side under formula.Two or six lens 26 are double-concave negative lens, and the two or seven lens 27 are meniscus shaped lens, and the two can be
Curvature of field compensation is carried out close to intermediate image position.Two or eight lens 28 are biconvex positive lens.
Beneficial effect：The present invention ophthalmology imaging diagnosis system have concurrently realize OCT fundus imagings and OCT anterior ocular segments imaging
Function, and realize the inside switching of the two.After fundus imaging is switched to anterior ocular segment imaging, one has been increased newly in OCT image module
Individual second intermediary image, such a method cause light incide anterior ocular segment angle control it is more flexible, anterior ocular segment visual field resolution ratio refers to
Mark can improve.The present invention inside the light path of OCT image module using switching simultaneously, to other systems light path in handoff procedure
Do not influence.
Brief description of the drawings
Fig. 1 is the structural representation of OCT light paths in patent US8427654；
Fig. 2 is the structural representation for the OCT systems for making eyes refraction index test in patent US20080106696A1；
Fig. 3 is the first structure schematic diagram of OCT systems in patent CN102438505ZHONG；
Fig. 4 is the second structural representation of OCT systems in patent CN102438505ZHONG；
Fig. 5 is the 3rd structural representation of OCT systems in patent CN102438505ZHONG；
Fig. 6 is the structural representation of OCT systems in patent US2008/0106696A1；
Fig. 7 is the optical system diagram of first embodiment of the invention；
Fig. 8 is the optical system diagram of second embodiment of the invention；
Fig. 9 is switching OCT image module section microscope group in first embodiment of the invention, completes OCT eyeground and anterior ocular segment
The structure chart of switching；
Figure 10 is the whole microscope groups for switching OCT image module in first embodiment of the invention, completes OCT eyeground and at the moment
Save the structure chart of switching；
Figure 11 is switching OCT image module section microscope group in second embodiment of the invention, completes OCT eyeground and anterior ocular segment
The structure chart of switching；
Figure 12 is the whole microscope groups for switching OCT image module in second embodiment of the invention, completes OCT eyeground and at the moment
Save the structure chart of switching.
Embodiment
Make specific introduce to the present invention below in conjunction with specific embodiment.
The present invention is ophthalmology imaging diagnosis system, and the inside switching method of proposition, user's operation is simply.In view of tested
Object diopter is different, in order to ensure fixation system can blur-free imaging, be both needed to progress Diopter accommodation on eyeground and at the moment.This hair
Bright use switches inside OCT light paths, and fixation system light path is not influenceed in handoff procedure.
Present invention realization from eyeground OCT image after anterior ocular segment OCT image is switched to, image position among OCT light paths Central Plains
While constant, increased an intermediary image newly, such a method cause light incide anterior ocular segment angle control it is more flexible, can
To realize telecentric imaging.And anterior ocular segment visual field resolution ratio index can improve.
Diagnostic system based on ophthalmology OCT technology described in the embodiment of the present invention, including OCT image module, laser scanning eye
Bottom mirror (scanning laser ophthalmoscope) image-forming module, anterior ocular segment photographing module and fixation target module system.Respectively
Image-forming module operation wavelength is different, is boundary by multiple dichroscopes, is completed according to the dichroism of dichroscope each
The imaging of wave band and illumination functions.
Technical problems to be solved of the embodiment of the present invention：One, there is provided a kind of diagnostic system based on ophthalmology OCT technology and its
Imaging method, during realizing eyeground and anterior ocular segment OCT image function switch, ensure other auxiliary positionings, diagnostic function not by
Influence, i.e. anterior ocular segment photographing module, eyeground SLO scanning laser ophthalmoscope modules, and the imaging of fixation module is unaffected；Two,
After from eyeground, OCT is switched to anterior ocular segment OCT patterns, OCT image inside modules have increased an intermediary image newly, and such a method causes light
The angle control that line incides anterior ocular segment is more flexible, and can realize anterior ocular segment telecentric imaging, and anterior ocular segment visual field resolution ratio
Index can improve.
Ophthalmology imaging diagnosis system, including the two kinds of OCT image patterns in eyeground and anterior ocular segment, under the OCT image pattern of eyeground,
By switching part or whole OCT image modules, complete eyeground to anterior ocular segment imaging pattern and switch.OCT image module is to connect mesh
All on-plane surface optical elements between mirror and galvanometer.OCT image module, moved according to instruction by the microscope group of OCT light paths, from one
Pattern switching is planted to another scan pattern.Anterior ocular segment imaging pattern can increase in OCT image module with respect to fundus imaging pattern
One intermediate image plane, and it is different from the intermediate image position of eyeground pattern.
In OCT fundus imagings pattern and anterior ocular segment pattern, OCT galvanometers theoretical position is all theoretical under two kinds of imaging patterns
Aperture diaphragm position, and the position with eye pupil conjugation.The switching of eyeground and anterior ocular segment is actually approximate picture
The switching in face and pupil face, the intermediate image face position in the present invention under OCT fundus imaging patterns, in OCT anterior ocular segment imaging patterns
It is the approximate conjugate position of imaging optical path aperture diaphragm down, i.e., equally completes switching of the image planes to pupil face.Eye is incided in addition
Preceding light is less parallel light, therefore intermediate image position is the back focal length position of approximate ocular lens under fundus imaging pattern,
Switch to anterior ocular segment pattern back aperture stop position to be also similar to the coincidence of eyepiece back focal length position, the telecentricity of anterior ocular segment is realized with this
Imaging.OCT eyeground and anterior ocular segment imaging optical path handoff procedure, no planar optical elements participate in switching movement, or change position or
Direction.OCT eyeground and anterior ocular segment imaging optical path handoff procedure, speculum or other planar waves need not be increased or decreased in light path
Element.
We can assume that having the first aperture diaphragm in the OCT image pattern of eyeground, the first aperture diaphragm position is to sweep
Retouch galvanometer position, and the first aperture diaphragm and eye pupil imaging conjugate；Have first in section OCT image pattern before eyes
Aperture diaphragm and the second aperture diaphragm, the first aperture diaphragm position is constant, and the second aperture diaphragm is located at ocular lens and OCT image mould
Between block, and the second aperture diaphragm and the first aperture diaphragm imaging conjugate.
OCT fundus imagings pattern and the handoff procedure of anterior ocular segment imaging pattern, under the premise of considering 24mm standard human eye length,
After being ensured before the handover by optical design, sample arm optical path length is approximate consistent.Therefore during this switching, reference arm can
Reduce or omit the compensation rate of coherence length.
When ophthalmology imaging diagnosis system carries out eyeground scanning imagery, near infrared light reaches galvanometer scanning device, then successively
By OCT fundus imagings module and ocular lens, and focus on eyeground.Light after fundus reflex and scattering, backtracking is extremely
Galvanometer.Its imaging optical path is characterized as thering is an intermediate image face, this intermediate image plane between OCT fundus imagings module and ocular lens
It is approximately telecentric imaging.
When ophthalmology imaging diagnosis system carries out anterior ocular segment scanning imagery, near-infrared light source passes through galvanometer scanning device, enters
OCT anterior ocular segments image-forming module and ocular lens, and focus on anterior ocular segment.Light after anterior ocular segment reflects and scatters, backtracking
To galvanometer.Its imaging optical path is characterized as：First, OCT fundus imaging patterns intermediate image face identical position, section imaging before eyes
It is changed into the approximate conjugate position of imaging optical path diaphragm under pattern.Second, OCT anterior ocular segments image-forming module is relative to OCT fundus imagings
Module, inside increase an intermediate image face newly.Third, before OCT anterior ocular segment module intermediate image planes or after intermediate image plane, there is at least one
Individual negative-power lenses.
SLO scanning laser ophthalmoscopes module in ophthalmology imaging diagnosis system, for the associated image using eyeground as imageable target
Module.During SLO scanning imageries, the infrared diaphanoscopy light source with OCT different-wavebands, successively by SLO galvanometer scanning devices, SLO
Fundus imaging module and ocular lens, and focus on eyeground.Light after fundus reflex and scattering, backtracking to SLO scan
Galvanometer.
Embodiment 1：
Ophthalmology imaging diagnosis system, as shown in fig. 7, OCT image module, SLO scanning laser ophthalmoscope image-forming modules, at the moment
Save photographing module and fixation target module shares ocular lens.The operating distance L1A of ocular lens to tested human eye is adjustable, in order to eye
Prosthomere conjugate imaging system focuses on；It is adjustable to the first two distance L2A to dichronic mirror DM01 after ocular lens, with for human eye
Hetero refraction difference compensates, and can specifically be compensated for +/- 20 power range.
Ophthalmology imaging diagnosis system, as shown in fig. 7, OCT image module and SLO image-forming modules are all in where the eyes optical axis
The same side of straight line；Anterior ocular segment photographing module is in relative opposite side.This embodiment advantage is two that SLO image-forming modules pass through
Only a piece of to dichronic mirror quantity, it is minimum to the influence as matter and transmitance.
In the present embodiment between OCT image module and other functional modules, by DM01A long waves reflecting short transmission two to
Dichronic mirror carries out light path separating.R1A relayings group is SLO image-forming modules, and anterior ocular segment photographing module and fixation module share microscope group.
Between SLO image-forming modules and anterior ocular segment photographing module, fixation module, two are transmitted to dichronic mirror by DM02A long waves reflecting short
Carry out light path separating.R2A relayings group is that anterior ocular segment photographing module and fixation module share microscope group.Anterior ocular segment photographing module and fixation
Object module, light path separating is carried out to dichronic mirror by DM03A long waves reflecting short transmission two.
OCT image module shown in Fig. 7 is eyeground pattern in the present embodiment, can by switching OCT image module section microscope group,
The switching of two imaging patterns in OCT eyeground and anterior ocular segment is completed, as shown in Figure 9.Two imaging patterns in OCT eyeground and anterior ocular segment
Switching, also the switching of two imaging patterns in OCT eyeground and anterior ocular segment can be completed, such as by switching OCT image module whole microscope group
Shown in Figure 10.
In OCT fundus imagings pattern and anterior ocular segment pattern, OCT galvanometers theoretical position is all theoretical under two kinds of imaging patterns
Aperture diaphragm position.The switching of eyeground and anterior ocular segment is actually approximate image planes and the switching in pupil face, in the present embodiment
Intermediate image face position under OCT fundus imaging patterns, it is the near of imaging optical path aperture diaphragm under OCT anterior ocular segment imaging patterns
Like conjugate position, i.e., equally complete switching of the image planes to pupil face.The light incided in addition at the moment is less parallel light, therefore
Intermediate image position is the back focal length position of approximate ocular lens under fundus imaging pattern, switches to anterior ocular segment pattern back aperture diaphragm
Position is also similar to the coincidence of eyepiece back focal length position, and the telecentric imaging of anterior ocular segment is realized with this.
Image-forming module is made up of the first lens 11, the second lens 12, the 3rd lens 13 under the pattern of OCT eyeground in Fig. 9.First
Lens 11 are biconvex lens, and wherein S1 faces should be near the optical surface of approximate diaphragm conjugate position after being switched to anterior ocular segment pattern
(i.e. close with galvanometer and the optical surface of eye pupil conjugate position), veiling glare is easily produced if lens S1 faces are designed as plane
Ghost image, therefore constrain S1 radius surfaces and be less than 300mm.Second lens 12 are meniscus shaped lens, and two surfaces bend towards OCT galvanometers reason
By position.3rd lens 13 are biconvex lens.3rd lens 13 be near OCT galvanometer theoretical positions, the second lens 12 and
The distance between 3rd lens 13 L0The space switched for eyeground and anterior ocular segment, L0Meet following constraints：
Wherein, L1For the distance of any point a in the first intermediate image plane and the first dichronic mirror, L2To be any on the first dichronic mirror
Point a to galvanometer distance.
Image-forming module in addition to the first lens 11, the second lens 12, the 3rd lens 13, also wraps under OCT anterior ocular segments pattern in Fig. 9
The 4th lens 14, the 5th lens 15, the 6th lens 16 are included to form.4th lens 14 are approximate planoconvex spotlight, almost plane be by
The one side of nearly anterior ocular segment intermediate image plane, the convex surface center of circle is in OCT galvanometers side.Opposite side close to the intermediate image plane has a negative light
The lens 15 of focal power the 5th, to carry out curvature of field compensation near intermediate image plane.And the lens 15 of negative power the 5th are in intermediary image
Between face and OCT galvanometer theoretical positions.The 6th close lens 16 are positive lens therewith, are meniscus shaped lens, the circle in two faces
The heart is away from OCT galvanometers side.
As shown in FIG. 9 and 10, an intermediary image can be increased in switching OCT to anterior ocular segment pattern, OCT image module
Face, and it is different from the intermediate image position of eyeground pattern.Intermediate image face position under OCT fundus imaging patterns, before OCT
Save under imaging pattern as the approximate conjugate position of imaging optical path aperture diaphragm.OCT eyeground and anterior ocular segment imaging optical path handoff procedure,
Switching movement is participated in without planar optical elements, or changes position or orientation.OCT eyeground and anterior ocular segment imaging optical path handoff procedure,
Speculum or other planar optical elements need not be increased or decreased in light path.Cut on OCT modules eyeground and anterior ocular segment scan pattern
Change process, other modules are such as in system：SLO modules, the imaging of anterior ocular segment photographing module and fixation target module and illumination path
It is unaffected.
The present embodiment, in fundus imaging pattern and the handoff procedure of anterior ocular segment imaging pattern, consider 24mm standards human eye length
Under the premise of degree, after being ensured before the handover by optical design, sample arm optical path length is approximate consistent.Therefore in this handoff procedure
In, reference arm can reduce or omit the variable quantity of coherence length.
In formula, OPLretinaRepresent optical path length under the pattern of eyeground, OPLcorneaRepresent optical path length under anterior ocular segment pattern.
Embodiment 2：
Ophthalmology imaging diagnosis system, as shown in figure 8, OCT image module, SLO scanning laser ophthalmoscope image-forming modules, at the moment
Save photographing module and fixation target module shares ocular lens.The operating distance L1B of ocular lens to tested human eye is adjustable, in order to eye
Prosthomere conjugate imaging system focuses on；It is adjustable to the first two distance L2B to dichronic mirror DM01 after ocular lens, with for human eye
Hetero refraction difference compensates, and can specifically be compensated for +/- 20 power range.
Ophthalmology imaging diagnosis system, as shown in figure 8, OCT image module, fixation module, all locates with anterior ocular segment photographing module
The same side of straight line where the eyes optical axis, and anterior ocular segment photographing module is in relative opposite side.This embodiment advantage is each
Module distribution is compact, and system bulk is small.And DM02B is long wave transmission shortwave reflection dichroscope, the optional scope of product is big.
In the present embodiment between OCT image module and other functional modules, by DM01B long waves reflecting short transmission two to
Dichronic mirror carries out light path separating.R1B relayings group is SLO image-forming modules, and anterior ocular segment photographing module and fixation module share microscope group.
Between SLO image-forming modules and anterior ocular segment photographing module, fixation module, shortwave reflection two is transmitted to dichronic mirror by DM02B long waves
Carry out light path separating.R2B relayings group is that anterior ocular segment photographing module and fixation module share microscope group.Anterior ocular segment photographing module and fixation
Object module, light path separating is carried out to dichronic mirror by DM03B long waves reflecting short transmission two.
Eyeground switches with anterior ocular segment in specific OCT image module, as shown in figure 11, image-forming module under the pattern of OCT eyeground
It is made up of the first lens 21, the second lens 22, the 3rd lens 23.First lens 21 are biconvex positive lens.Second lens 22 are curved
Moon-shaped lens are to balance the curvature of field, and two face center of circle is away from OCT galvanometer theoretical positions side.3rd lens 23 are also to be curved
Moon-shaped lens, and two faces center of circle is close to OCT galvanometer theoretical positions side.
Image-forming module in addition to the first lens 21, the second lens 22, the 3rd lens 23, also wraps under OCT anterior ocular segments pattern in Fig. 9
Include the two or four lens 24, the two or five lens 25, the two or six lens 26, the two or seven lens 27, the two or eight lens 28.Two or four lens
24 and second without lens 25 be meniscus shaped lens, and the face center of circle is in the intermediate image plane side under anterior ocular segment imaging pattern.The
Two or six lens 26 are double-concave negative lens, and the two or seven lens 27 are meniscus shaped lens, and the two can enter close to intermediate image position
The row curvature of field compensates.Two or eight lens 28 are biconvex positive lens.
OCT image module shown in Fig. 8 is eyeground pattern in the present embodiment, can by switching OCT image module section microscope group,
The switching of two imaging patterns in OCT eyeground and anterior ocular segment is completed, as shown in figure 11.Or can be by switching OCT image module whole
Microscope group, the switching of two imaging patterns in OCT eyeground and anterior ocular segment is completed, as shown in figure 12.As shown in FIG. 9 and 10, switching
OCT can increase an intermediate image plane to anterior ocular segment pattern in OCT image module, and with the intermediate image position of eyeground pattern not
Together.In OCT fundus imagings pattern and anterior ocular segment pattern, OCT galvanometers theoretical position is all theoretical pore under two kinds of imaging patterns
Diaphragm position.The switching of eyeground and anterior ocular segment is actually approximate image planes and the switching in pupil face, OCT eyes in the present embodiment
Intermediate image face position under the imaging pattern of bottom, it is total under OCT anterior ocular segment imaging patterns for the approximation of imaging optical path aperture diaphragm
Yoke position, i.e., equally complete switching of the image planes to pupil face.The light incided in addition at the moment is less parallel light, therefore eyeground
Intermediate image position is the back focal length position of approximate ocular lens under imaging pattern, switches to anterior ocular segment pattern back aperture stop position
Also it is similar to the coincidence of eyepiece back focal length position, the telecentric imaging of anterior ocular segment is realized with this.Scanned on OCT modules eyeground and anterior ocular segment
Mode handover procedure, other modules are such as in system：SLO modules, the imaging of anterior ocular segment photographing module and fixation target module and photograph
Mingguang City road is unaffected.
Claims (11)
- A kind of 1. ophthalmology imaging diagnosis system, it is characterised in that including ocular lens and OCT image module, the OCT image module Including eyeground OCT image pattern and anterior ocular segment OCT image pattern；OCT image module has the first intermediate image plane in the eyeground OCT image pattern, and first intermediate image plane is positioned at described Between ocular lens and OCT image module；Lens group, the OCT image are set in the inside light path of the OCT image module of the eyeground OCT image pattern Module has the second intermediate image plane, and second intermediate image plane is located in the OCT image module, the OCT image module The conjugate position of imaging optical path aperture diaphragm obtains anterior ocular segment OCT image mould between the ocular lens and OCT image module Formula.
- 2. ophthalmology imaging diagnosis system as claimed in claim 1, it is characterised in that also including the first dichronic mirror, the OCT into As module is arranged on the side of first dichronic mirror, the ocular lens are arranged on the reflected light path or thoroughly of first dichronic mirror Penetrate in light path, first intermediate image plane is between the ocular lens and the first dichronic mirror.
- 3. ophthalmology imaging diagnosis system as claimed in claim 1, it is characterised in that in the eyeground OCT of the OCT image module In imaging pattern and anterior ocular segment OCT image pattern, the light path ratio of eyeground pattern and anterior ocular segment pattern meets following formula requirement：<mrow> <mn>0.9</mn> <mo>&le;</mo> <mfrac> <mrow> <msub> <mi>OPL</mi> <mrow> <mi>r</mi> <mi>e</mi> <mi>t</mi> <mi>i</mi> <mi>n</mi> <mi>a</mi> </mrow> </msub> </mrow> <mrow> <msub> <mi>OPL</mi> <mrow> <mi>c</mi> <mi>o</mi> <mi>r</mi> <mi>n</mi> <mi>e</mi> <mi>a</mi> </mrow> </msub> </mrow> </mfrac> <mo>&le;</mo> <mn>1.1</mn> </mrow>In formula, OPLretinaRepresent optical path length under the pattern of eyeground, OPLcorneaRepresent optical path length under anterior ocular segment pattern.
- 4. ophthalmology imaging diagnosis system as claimed in claim 2, it is characterised in that also including the second dichronic mirror and eyeground SLO Scanning laser ophthalmoscope module, second dichronic mirror are arranged on the transmitted light path or reflected light path of first dichronic mirror, The first relay, the eyeground SLO laser scannings are provided with light path between second dichronic mirror and the first dichronic mirror Ophthalmoscope module is arranged on the reflected light path or transmitted light path of second dichronic mirror.
- 5. ophthalmology imaging diagnosis system as claimed in claim 4, it is characterised in that also including the 3rd dichronic mirror, fixation target Module and anterior ocular segment photographing module, the 3rd dichronic mirror are arranged on the transmitted light path or reflected light path of second dichronic mirror On, the second relay is provided between the 3rd dichronic mirror and the second dichronic mirror, the fixation target module is arranged on institute On the transmitted light path or reflected light path for stating the 3rd dichronic mirror, the anterior ocular segment photographing module is arranged on the anti-of the 3rd dichronic mirror Penetrate on light path or transmitted light path.
- 6. ophthalmology imaging diagnosis system as claimed in claim 2, it is characterised in that also including OCT galvanometers, the OCT galvanometers It is arranged on the one end of the OCT image module away from first dichronic mirror.
- 7. ophthalmology imaging diagnosis system as claimed in claim 1, it is characterised in that it is saturating that the OCT image module includes first Microscope group and the 3rd lens (13；23), first lens group includes the first lens (11；And the second lens (12 21)；22) it is, described First lens (11；21) close to the ocular lens, second lens are away from the ocular lens, the 3rd lens (13；23) It is arranged on the side of first lens group away from the ocular lens.
- 8. ophthalmology imaging diagnosis system as claimed in claim 7, it is characterised in that it is saturating that the lens group is arranged on described second Mirror (12；And the 3rd lens (13 22)；23) between.
- 9. ophthalmology imaging diagnosis system as claimed in claim 1, it is characterised in that the lens group include the second lens group and 3rd lens group, second lens group and the 3rd lens group are located at the both sides of second intermediate image plane respectively.
- 10. ophthalmology imaging diagnosis system as claimed in claim 9, it is characterised in that it is saturating that second lens group includes the 4th Mirror (14), the 3rd lens group include the 5th lens (15) and the 6th lens (16), the 5th lens (15) and the 6th saturating Mirror (16) is successively away from second intermediate image plane.
- 11. ophthalmology imaging diagnosis system as claimed in claim 9, it is characterised in that second lens group includes the two or four Lens (24) and the two or five lens (25), the two or four lens (24) and the two or five lens (25) are successively away from described second Between image planes, the 3rd lens group includes the two or six lens (26), the two or seven lens (27) and the two or eight lens (28), described Two or six lens (26), the two or seven lens (27) and the two or eight lens (28) are successively away from second intermediate image plane.
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| CN201710991897.2A CN107582020B (en) | 2017-10-20 | 2017-10-20 | A kind of ophthalmology imaging diagnosis system |
| ES18868874T ES2899428T3 (en) | 2017-10-20 | 2018-10-18 | Ophthalmic Imaging Diagnostic System |
| EP18868874.1A EP3692892B1 (en) | 2017-10-20 | 2018-10-18 | Ophthalmic imaging diagnostic system |
| PCT/CN2018/110791 WO2019076335A1 (en) | 2017-10-20 | 2018-10-18 | Ophthalmic imaging diagnostic system |
| US16/853,743 US11638520B2 (en) | 2017-10-20 | 2020-04-20 | Ophthalmic imaging system |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108378819A (en) * | 2018-05-02 | 2018-08-10 | 重庆贝奥新视野医疗设备有限公司 | Fundus camera and virtual reality imaging device |
| CN108784645A (en) * | 2018-07-18 | 2018-11-13 | 视微影像(河南)科技有限公司 | A kind of switching device of optics microscope group |
| CN109124566A (en) * | 2018-08-13 | 2019-01-04 | 青岛市市立医院 | A kind of ophthalmology imaging system with the detection of automatic retinal feature |
| WO2019076335A1 (en) * | 2017-10-20 | 2019-04-25 | 视微影像(河南)科技有限公司 | Ophthalmic imaging diagnostic system |
| CN110755031A (en) * | 2019-10-31 | 2020-02-07 | 天津迈达医学科技股份有限公司 | Optical coherent tomography system for anterior-posterior segment frequency domain of eye |
| CN111643050A (en) * | 2020-06-10 | 2020-09-11 | 苏州比格威医疗科技有限公司 | Ophthalmic optical imaging system |
| CN112105287A (en) * | 2018-03-30 | 2020-12-18 | 株式会社尼康 | Ophthalmologic optical system, ophthalmologic objective lens, and ophthalmologic apparatus |
| CN113520298A (en) * | 2021-06-15 | 2021-10-22 | 上海应用技术大学 | Anterior-posterior segment integrated optical coherence tomography structure/function imaging system |
| CN113545744A (en) * | 2021-08-20 | 2021-10-26 | 图湃(北京)医疗科技有限公司 | Ophthalmic optical imaging diagnostic system |
| CN114930115A (en) * | 2019-12-18 | 2022-08-19 | 巴黎科学与文学基金会 | Full-field optical coherence tomography method |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1535392A (en) * | 2000-10-23 | 2004-10-06 | 株式会社尼康 | Catadioptric systema and exposure device having this system |
| US20080106696A1 (en) * | 2006-11-01 | 2008-05-08 | Bioptigen, Inc. | Optical coherence imaging systems having a mechanism for shifting focus and scanning modality and related adapters |
| US20090303438A1 (en) * | 2008-06-02 | 2009-12-10 | Nidek Co., Ltd. | Ophthalmic photographing apparatus |
| CN102438505A (en) * | 2011-04-23 | 2012-05-02 | 深圳市斯尔顿科技有限公司 | Ophthalmology oct system and ophthalmology imaging method |
| US20120140238A1 (en) * | 2006-06-20 | 2012-06-07 | Carl Zeiss Meditec, Inc. | Spectral domain optical coherence tomography system |
| CN103251382A (en) * | 2013-04-17 | 2013-08-21 | 温州医学院 | All-eye frequency-domain optical coherence tomography system and method |
| CN103565401A (en) * | 2012-07-27 | 2014-02-12 | 上海威景生物科技有限公司 | Full-eyeball optical coherent tomography adaptive system and full-eyeball optical coherent tomography adaptive method |
| JP2014042650A (en) * | 2012-08-27 | 2014-03-13 | Canon Inc | Image processing apparatus and image processing method |
| CN103926679A (en) * | 2013-01-11 | 2014-07-16 | 晋弘科技股份有限公司 | Lens module and fundus camera |
| CN105615824A (en) * | 2016-03-25 | 2016-06-01 | 中国科学院光电技术研究所 | Long-focus deep-dark-field retina OCT system adopting Bessel band lighting mode |
| US20170296047A1 (en) * | 2012-09-28 | 2017-10-19 | Carl Zeiss Meditec Ag | Device for reliably determining biometric measurement variables of the whole eye |
-
2017
- 2017-10-20 CN CN201710991897.2A patent/CN107582020B/en active Active
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1535392A (en) * | 2000-10-23 | 2004-10-06 | 株式会社尼康 | Catadioptric systema and exposure device having this system |
| US20120140238A1 (en) * | 2006-06-20 | 2012-06-07 | Carl Zeiss Meditec, Inc. | Spectral domain optical coherence tomography system |
| US20080106696A1 (en) * | 2006-11-01 | 2008-05-08 | Bioptigen, Inc. | Optical coherence imaging systems having a mechanism for shifting focus and scanning modality and related adapters |
| US20090303438A1 (en) * | 2008-06-02 | 2009-12-10 | Nidek Co., Ltd. | Ophthalmic photographing apparatus |
| CN102438505A (en) * | 2011-04-23 | 2012-05-02 | 深圳市斯尔顿科技有限公司 | Ophthalmology oct system and ophthalmology imaging method |
| CN103565401A (en) * | 2012-07-27 | 2014-02-12 | 上海威景生物科技有限公司 | Full-eyeball optical coherent tomography adaptive system and full-eyeball optical coherent tomography adaptive method |
| JP2014042650A (en) * | 2012-08-27 | 2014-03-13 | Canon Inc | Image processing apparatus and image processing method |
| US20170296047A1 (en) * | 2012-09-28 | 2017-10-19 | Carl Zeiss Meditec Ag | Device for reliably determining biometric measurement variables of the whole eye |
| CN103926679A (en) * | 2013-01-11 | 2014-07-16 | 晋弘科技股份有限公司 | Lens module and fundus camera |
| CN103251382A (en) * | 2013-04-17 | 2013-08-21 | 温州医学院 | All-eye frequency-domain optical coherence tomography system and method |
| CN105615824A (en) * | 2016-03-25 | 2016-06-01 | 中国科学院光电技术研究所 | Long-focus deep-dark-field retina OCT system adopting Bessel band lighting mode |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019076335A1 (en) * | 2017-10-20 | 2019-04-25 | 视微影像(河南)科技有限公司 | Ophthalmic imaging diagnostic system |
| CN112105287A (en) * | 2018-03-30 | 2020-12-18 | 株式会社尼康 | Ophthalmologic optical system, ophthalmologic objective lens, and ophthalmologic apparatus |
| CN112105287B (en) * | 2018-03-30 | 2023-09-01 | 株式会社尼康 | Ophthalmic device and ophthalmic optical system |
| CN108378819A (en) * | 2018-05-02 | 2018-08-10 | 重庆贝奥新视野医疗设备有限公司 | Fundus camera and virtual reality imaging device |
| CN108378819B (en) * | 2018-05-02 | 2023-10-27 | 重庆贝奥新视野医疗设备有限公司 | Fundus camera and virtual reality imaging apparatus |
| CN108784645A (en) * | 2018-07-18 | 2018-11-13 | 视微影像(河南)科技有限公司 | A kind of switching device of optics microscope group |
| CN108784645B (en) * | 2018-07-18 | 2020-06-23 | 视微影像(河南)科技有限公司 | Switching device of optical lens group |
| CN109124566A (en) * | 2018-08-13 | 2019-01-04 | 青岛市市立医院 | A kind of ophthalmology imaging system with the detection of automatic retinal feature |
| CN110755031A (en) * | 2019-10-31 | 2020-02-07 | 天津迈达医学科技股份有限公司 | Optical coherent tomography system for anterior-posterior segment frequency domain of eye |
| CN110755031B (en) * | 2019-10-31 | 2021-11-12 | 天津迈达医学科技股份有限公司 | Optical coherent tomography system for anterior-posterior segment frequency domain of eye |
| CN114930115A (en) * | 2019-12-18 | 2022-08-19 | 巴黎科学与文学基金会 | Full-field optical coherence tomography method |
| CN111643050A (en) * | 2020-06-10 | 2020-09-11 | 苏州比格威医疗科技有限公司 | Ophthalmic optical imaging system |
| CN113520298A (en) * | 2021-06-15 | 2021-10-22 | 上海应用技术大学 | Anterior-posterior segment integrated optical coherence tomography structure/function imaging system |
| WO2023020616A1 (en) * | 2021-08-20 | 2023-02-23 | 图湃(北京)医疗科技有限公司 | Optical imaging ophthalmic diagnosis system |
| CN113545744A (en) * | 2021-08-20 | 2021-10-26 | 图湃(北京)医疗科技有限公司 | Ophthalmic optical imaging diagnostic system |
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