CN107537181A - Isolate and purify system - Google Patents
Isolate and purify system Download PDFInfo
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- CN107537181A CN107537181A CN201711002699.5A CN201711002699A CN107537181A CN 107537181 A CN107537181 A CN 107537181A CN 201711002699 A CN201711002699 A CN 201711002699A CN 107537181 A CN107537181 A CN 107537181A
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- isolates
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Abstract
The present invention relates to natural products equipment for purifying technical field, more particularly to a kind of Chinese medicine extract isolates and purifies system.One kind isolates and purifies system, including pump machine, extractor, membrane separation assemblies and the decolorizing column being sequentially connected, it is characterised in that：Purification column is connected between the membrane separation assemblies and decolorizing column, the purification column includes purifying tank, support plate, stands groove, refined liquid bath, base and the concussion motor on the support plate；It is described purifying tank have it is multiple, by the first elastic guide post be arranged on described support plate on；The support plate is arranged on described base by the second elastic guide post；The purifying tank includes tank body, inlet, solvent inlet and the liquid outlet for being located at tank base.The invention is while the big molecular impurity in removing Chinese medicine crude extract, moreover it is possible to removes dissolved impurity in Chinese medicine crude extract, and cost is cheap.
Description
Technical field
The present invention relates to natural products equipment for purifying technical field, more particularly to a kind of isolating and purifying for Chinese medicine extract to be
System.
Background technology
In the production technology of Chinese medical extract, typically after the preliminary extraction by Chinese medicine, it is also necessary to purified
It is refined.The chemical composition of Chinese medicine is sufficiently complex, both contains plurality of active ingredients, contains invalid components, even toxic component again,
Therefore, extract its active ingredient and further it is isolated and purified, obtain one that effective monomer is traditional Chinese medicine research field
Important content.
The patent document of Application No. 201620934071.3 discloses such a Chinese medicine extract and isolates and purifies system,
Characterized in that, it includes extractor, membrane separation assemblies, chromatographic column and concentration and crystallization device, the extractor bottom is provided with
Inlet and solvent inlet port, extraction pot bottom are provided with extracting liquid outlet, and the extracting liquid outlet is connected with woven hose；The film point
MF microporous membrane filters, UF film filters and the RO film mistakes for including being flowed to direction by extract solution and being passed sequentially through pipeline connection from component
Filter；The filter liquor mouth of RO film filters is connected by pipeline with chromatographic column, and the chromatographic column is provided with eluent entrance, eluent
Elution liquid pipe is connected with entrance, the bottom of chromatographic column is connected by chromatographing liquid pipe with concentration and crystallization device, in the chromatography liquid pipe
Provided with compression pump and flowmeter.The system is mainly used in removing the big molecular impurity in Chinese medicine crude extract, and can not remove Chinese medicine
In crude extract together with active ingredient dissolved impurity, and cost is higher.
The content of the invention
The invention solves above mentioned problem, there is provided one kind isolates and purifies system, its big point in Chinese medicine crude extract is removed
While sub- impurity, moreover it is possible to remove dissolved impurity in Chinese medicine crude extract, and cost is cheap.
The present invention solves the technical scheme that technical problem uses, and proposes that one kind isolates and purifies system, including be sequentially connected
Pump machine, extractor, membrane separation assemblies and decolorizing column, it is characterised in that：It is connected between the membrane separation assemblies and decolorizing column
Purification column, the purification column include purifying tank, support plate, stand groove, refined liquid bath, base and the concussion on the support plate
Motor；It is described purifying tank have it is multiple, by the first elastic guide post be arranged on described support plate on；The support plate passes through the second bullet
Property guide pillar be arranged on described base on；The purifying tank includes tank body, inlet, solvent inlet and is located at going out for tank base
Liquid mouth；First elastic guide post and the second elastic guide post include guide pillar and the spring being set on guide pillar.
Preferably, the purifying tank has multiple, between the liquid outlet of the tank base of multiple described purifying tanks mutually
Connection forms liquid outlet channel.
Preferably, air pressure balance mouth is additionally provided with the tank body.
Preferably, the groove that stands is arranged on the lower section of the support plate, and is connected with described liquid outlet channel.
Preferably, filter opening is offered on the bottom plate for standing groove.
Preferably, it is equipped with filter paper on the bottom plate for standing groove.
Preferably, the refined liquid bath is furnished with the vacuum filtration machine being attached thereto.
Preferably, refined liquid outlet and liquid taking port are additionally provided with the refined liquid bath.
Preferably, resilient snubber is provided between the tank body.
Beneficial effects of the present invention:
1. remove big molecular impurity, purification column can remove dissolved impurity in Chinese medicine crude extract.2. concussion component is set
Meter so that the mixing between solvent and the solution being purified is more uniformly distributed, so as to improve purification efficiency.3. by automation equipment
A production line is formed, cost is cheap, simple in construction, easy to operate.
Brief description of the drawings
Fig. 1 is a kind of structural representation for isolating and purifying system；
Fig. 2 is a kind of concussion structural representation for the purification column for isolating and purifying system；
Fig. 3 is a kind of charging and discharging schematic diagram for the purification column for isolating and purifying system；
In figure：100- pump machines, 200- extractors, 300- membrane separation assemblies, 400- purification columns, 410- purifying tanks, 411- inlets,
412- solvent inlets, 413- liquid outlets, 414- air pressure balance mouths, 415- resilient snubbers, 420- support plates, 430- stand groove,
440- liquid outlet channels, 450- refine liquid bath, 451- vacuum filtration machines, the outlet of 452- refined liquids, 453- liquid taking ports, the bullets of 460- first
Property guide pillar, the elastic guide posts of 470- second, 480- bases, 490- concussion motor, 500- decolorizing columns.
Embodiment
It is below the specific embodiment of the present invention, and technical scheme is further described with reference to accompanying drawing,
But the present invention is not limited to these embodiments.
One kind isolates and purifies system, as shown in figure 1, this system that isolates and purifies is used to carry out extraction purification to Chinese medicine,
This isolates and purifies pump machine 100, extractor 200, membrane separation assemblies 300, purification column 400 and the decolorizing column that system includes being sequentially connected
500。
When being isolated and purified, the Chinese medicine crude extract from extractor 200 passes through membrane separation assemblies in the presence of pump machine
300, to remove the big molecular impurities such as the protein in Chinese medicine crude extract, thalline, starch, suspended particulate.Obtain preliminary purification
Chinese medicine crude extract is further isolated and purified in the presence of pump machine 100 into purification column 400.
As shown in Fig. 2 purification column 400 includes purifying tank 410, support plate 420, stands groove 430, refined liquid bath 450, base
480 and concussion motor 490.
Shake motor 490 to be arranged on support plate 420, concussion power is provided for whole device.Support plate 420 and purifying tank 410
Connection so that purifying tank 410 obtains shaking power.
Purify tank 410 have it is multiple, by the first elastic guide post 460 be arranged on support plate 420 on：On support plate 420 have to
The guide pillar of upper extension, spring is arranged with guide pillar cylinder, the guide pillar and spring form the first elastic guide post 460.Purify tank 410
There is connecting rod on side, the through hole for being available for guide pillar to pass through is offered in connecting rod, one end of guide pillar is connected on support plate 420,
The other end passes through through hole, and the connection of one end of spring is also connected on support plate 420, and the connecting rod of the other end and purifying tank 410 connects
Connect so that purifying tank 410 can vibrate on support plate 420.
Be provided with resilient snubber 415 between purifying tank 410 on support plate 420, resilient snubber 415 can be rubber or
Person sponge so that purifying tank 410 will not mutually hit in upper and lower concussion or be hit with support plate 420, have protective effect.
Due to shaking the concussion effect of motor 490 so that support plate 420 can also obtain certain concussion, therefore in support plate 420
On be provided with base 480 play the supporting ＆ stablizing of support plate 420 effect.
Support plate 420 is arranged on base 480 by the second elastic guide post 470, with the first elastic guide post 460 similarly, second
Elastic guide post 470 also includes guide pillar and the spring being set on guide pillar, has on support plate 420 and is available for the through hole that guide pillar passes through, leads
One end of post is connected on base 480, and the other end passes through through hole, and one end of spring is connected on base 480, and the other end is with carrying
Plate 420 connects so that support plate 420 can vibrate while the support of base 480 is obtained under the influence of earthquake motor 490.
As shown in figure 3, purifying tank 410 includes tank body, inlet 411, solvent inlet 413, air pressure balance mouth 414 and is located at
The liquid outlet 413 of tank base；Air pressure balance mouth 414, which is used to discharge from what inlet 411 entered, is purified solution and from solvent
Caused bubble after the solvent mixing that import 413 enters, the inner and outer air pressure of tank 410 is purified with balance.
It is interconnected between the liquid outlet 413 of the tank base of multiple purifying tanks 410 and forms liquid outlet channel 440, is gone out liquid and lead to
Road 440 leads to the standing groove 430 of the lower section of support plate 420 installation so that is purified solution and the solvent energy after being mixed and being shaken
Enough flow into standing groove 430 carries out standing operation.
Stand and offer filter opening on the bottom plate of groove 430, and filter paper is equipped with its bottom surface, largely can be by solvent in Chinese medicine
The active ingredient that extracts, which is formed, to be precipitated and is deposited on filter paper, and containing on a small quantity can not be by the active ingredient that the solvent extraction goes out
Refined liquid is discharged to by filter paper and filter opening to be stood in the refined liquid bath 450 that the lower section of groove 430 is set.Especially, groove 430 is stood to set
It is set to drawer type so that the recovery precipitated outside purification column 400 and the replacing of filter paper can be extracted out by standing groove 430.
Refined liquid bath 450 is externally connected with vacuum filtration machine 451, because after standing a period of time, refined liquid can not be complete
Being separated with precipitation, vacuum filtration machine 451 can filter to solution, so as to be nearly completely separated out effectively precipitation and refined liquid,
Refined liquid is retracted in refined liquid bath 450 and deposited, and the refined lower section of liquid bath 450 offers refined liquid outlet 452 so that refined liquid can
Collected with being discharged.
Liquid taking port 453 is further opened with refined liquid bath 450, can be taken out a little by liquid taking port 453 from purification column 400 is outer
Liquid is detected, to judge degree of purification and effect.
The active ingredient finally obtained is sent to decolorizing column 500 and is further processed, so as to obtain the high Chinese medicine of purity
Extract.
Specific embodiment described herein is only to spirit explanation for example of the invention.Technology belonging to the present invention is led
The technical staff in domain can be made various modifications or supplement to described specific embodiment or be replaced using similar mode
Generation, but without departing from the spiritual of the present invention or surmount scope defined in appended claims.
Claims (9)
1. one kind isolates and purifies system, including the pump machine being sequentially connected（100）, extractor（200）, membrane separation assemblies（300）With
Decolorizing column（500）, it is characterised in that：The membrane separation assemblies（300）And decolorizing column（500）Between be connected with purification column（400）,
The purification column（400）Including purifying tank（410）, support plate（420）, stand groove（430）, refined liquid bath（450）, base（480）
With installed in the support plate（420）On concussion motor（490）；The purifying tank（410）With multiple, pass through the first elastic conducting
Post（460）Installed in described support plate（420）On；The support plate（420）Pass through the second elastic guide post（470）Installed in described
Base（480）On；The purifying tank（410）Including tank body, inlet（411）, solvent inlet（412）Be located at tank base
Liquid outlet（413）.
2. one kind according to claim 1 isolates and purifies system, it is characterised in that：The purifying tank（410）With multiple,
Multiple described purifying tanks（410）Tank base liquid outlet（413）Between be interconnected form liquid outlet channel（440）.
3. one kind according to claim 1 isolates and purifies system, it is characterised in that：Air pressure balance is additionally provided with the tank body
Mouthful（414）.
4. one kind according to claim 2 isolates and purifies system, it is characterised in that：The standing groove（430）Installed in institute
State support plate（420）Lower section, and with described liquid outlet channel（440）Connection.
5. one kind according to claim 4 isolates and purifies system, it is characterised in that：The standing groove（430）Bottom plate on
Offer filter opening.
6. one kind according to claim 5 isolates and purifies system, it is characterised in that：The standing groove（430）Bottom plate on
It is equipped with filter paper.
7. one kind according to claim 5 isolates and purifies system, it is characterised in that：The refined liquid bath（450）Equipped with
Connected vacuum filtration machine（451）.
8. one kind according to claim 5 isolates and purifies system, it is characterised in that：The refined liquid bath（450）On also set
There is refined liquid outlet（452）And liquid taking port（453）.
9. one kind according to claim 2 isolates and purifies system, it is characterised in that：Elastic buffer is provided between the tank body
Part（415）.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711002699.5A CN107537181A (en) | 2017-10-24 | 2017-10-24 | Isolate and purify system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711002699.5A CN107537181A (en) | 2017-10-24 | 2017-10-24 | Isolate and purify system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107537181A true CN107537181A (en) | 2018-01-05 |
Family
ID=60968207
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711002699.5A Pending CN107537181A (en) | 2017-10-24 | 2017-10-24 | Isolate and purify system |
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|---|---|
| CN (1) | CN107537181A (en) |
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| JP2006069959A (en) * | 2004-09-02 | 2006-03-16 | Kureha Engineering Co Ltd | Crystal purification method and apparatus therefor |
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180105 |
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