CN107510743A - 一种可有效治疗血热生风型斑秃的汤剂药物及制备方法 - Google Patents
一种可有效治疗血热生风型斑秃的汤剂药物及制备方法 Download PDFInfo
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Abstract
本发明属于中药制剂领域，目的是根据中医治疗血热生风型斑秃的认识机理而提供的一种可有效治疗血热生风型斑秃的汤剂药物，所述药物的各个组分及其质量份比如下：生地9～35g、赭石9～35g、女贞子6～18g、熟地黄9～16g、桑葚子10～16g、丹皮6～10g、赤芍6～15g、何首乌10～25g、山茱萸5～12g、玄参9～16g、菟丝子6～16g、白芍6～16g、茯神9～16g、当归8～18g、川芎3～12g、柴胡30～10g，本发明提供的药物是一个很好的中药组方。
Description
技术领域
本发明属于中药制剂领域，具体涉及一种可有效治疗血热生风型斑秃的汤剂药物，特别是供血热生风型斑秃患者使用的汤剂药物及制备方法的领域。
背景技术
据资料显示：本病是一种非瘢痕性脱发，常发生于身体有毛发的部位，局部皮肤正常，无自觉症状。
临床表现：
本病可发生于任何年龄，但以青壮年多见，两性发病率无明显差异。皮损表现为圆形或卵圆形非瘢痕性脱发，在斑秃边缘常可见“感叹号”样毛发。头发全部或几乎全部脱落，称为全秃。全身所有的毛发（包括体毛）都脱落，称为普脱。还可见匍行性脱发。病区皮肤除无毛发外，不存在其他异常。
有时可出现甲异常，最常见的是甲凹陷，还有脆甲、甲剥离、反甲等。还可并发眼白内障、Down综合征、甲状腺病和白癜风等。
那么，就如何找到一种可效治疗血热生风型斑秃的中药组合物，是本领域技术人员亟待要解决的问题。
发明内容
随着我国中医中药学的不断发展，在治疗血热生风型斑秃上，人们逐渐意识到了中医治疗血热生风型斑秃的优点，且在治疗过程中疗效好、见效快、毒副作用小等优势，针对现有西医治疗血热生风型斑秃的现状，本发明的目的是在于提供一种可有效治疗血热生风型斑秃的汤剂药物，以解决血热生风型斑秃患者早日恢复健康的问题。该药物是以常见的中药为原料，通过选择合理的药物及质量份比，可有效治疗上述血热生风型斑秃。
为达到上述发明的目的，本发明所采用的技术方案为：提供一种可有效治疗血热生风型斑秃的汤剂药物及制备方法，其特征在于，所述药物的各个组分及其质量份比如下所示：
生地9～35g、赭石9～35g、女贞子6～18g、熟地黄9～16g、桑葚子10～16g、丹皮6～10g、赤芍6～15g、何首乌10～25g、山茱萸5～12g、玄参9～16g、菟丝子6～16g、白芍6～16g、茯神9～16g、当归8～18g、川芎3～12g、柴胡30～10g。
一种可有效治疗血热生风型斑秃的汤剂药物及制备方法，其特征在于，所述药物的各个组分及其质量份比如下所示：
生地10～31g、赭石10～31g、女贞子7～16g、熟地黄10～14g、桑葚子11～14g、丹皮7～9g、赤芍7～13g、何首乌11～22g、山茱萸6～11g、玄参10～14g、菟丝子7～13g、白芍7～14g、茯神10～14g、当归10～16g、川芎5～11g、柴胡5～9g。
一种可有效治疗血热生风型斑秃的汤剂药物及制备方法，其特征在于，所述“最佳方案”的药物的各个组分及其质量份比如下所示：
生地28g、赭石28g、女贞子14g、熟地黄12g、桑葚子12g、丹皮8g、赤芍12g、何首乌20g、山茱萸10g、玄参12g、菟丝子12g、白芍12g、茯神12g、当归14g、川芎10g、柴胡8g。
一种可有效治疗血热生风型斑秃的汤剂药物及制备方法，其特征在于，所述方法包括如下步骤制备而成：
A、将上述原料中药拣去杂质和粉尘后，按照质量份比分别粉碎成粗粒状包煎；
B、①将包好的原料中药放入冷开水中浸泡45min，然后再将浸泡好的药物和浸泡药物的澄清液一并放入砂锅内，注入过药60mm的冷开水进行第一次武火煎煮，待煎煮到15min时，转文火熬制45 min，滤取药液；②药渣中再次注入过药55mm的微温开水进行第二次武火煎煮，待煎煮到10min时，转文火熬制35 min，滤取药液；③将两次药液混合浓缩成50%的中药液600ml（毫升）备用。
一种可有效治疗血热生风型斑秃的汤剂药物及制备方法，其特征在于，所述服用方法为：将制备好的中药液以一天服用，每日一剂，早中晚各服一次，给药量200ml（毫升）/次，趁温服，15天为一个疗程，治疗2～3个疗程，症状逐渐减轻或痊愈。
本发明组方中的各原料中药在中国药典、中国辞典以及中华本草中均有详细的记载。本发明选用其中最常见的中药为原料，充分发挥各组分的药理功效：
生地，性味：甘、苦、寒，具有滋阴、凉血之功效，用于治疗阴虚发热、热病伤阴、烦渴、骨蒸、斑疹、吐衄下血、妇女月经不调、胎动不安等症；
赭石，性味：苦、寒，具有平肝潜阳、降逆、止血之功效，用于治疗眩晕耳鸣、呕吐、噫气、呃逆、喘息、吐血、衄血、崩漏下血等症；
女贞子，性味：甘、苦、性凉，具有补益肝肾、清虚热、明目之功效，用于治疗头昏目眩、腰膝酸软、遗精、耳鸣、须发早白、骨蒸潮热、目暗不明等症；
熟地黄，性味：甘、微温，具有滋阴补血、益精填髓之功效，用于治疗肝肾阴虚、腰膝酸软、骨蒸潮热、盗汗遗精、内热消渴、血虚萎黄、心悸怔忡、月经不调、崩漏下血、眩晕、耳鸣、须发早白等症；
桑葚子，性味：甘、酸、性寒，具有滋阴养血、生津、润肠之功效，用于治疗肝肾不足和血虚精亏的头晕目眩、腰酸耳鸣、须发早白、失眠多梦、津伤口渴、消渴、肠燥便秘等症；
丹皮，性味：辛苦、凉、微寒，具有清热、活血散瘀之功效，用于治疗温热病热入血分、发斑、吐衄、热泪盈眶病菌后期热伏阴分发热、阴虚骨蒸潮热、血滞经闭、痛经、痈肿疮毒、跌扑伤痛、风湿热痹等症；
赤芍，性味：苦、微寒，具有清热凉血、活血祛瘀之功效，用于治疗温毒发斑、吐血衄血、肠风下血、目赤肿痛、痈肿疮疡、闭经、痛经、崩带淋浊、瘀滞胁痛、疝瘕积聚、跌扑损伤；
何首乌，性味：苦、甘、涩、性微温，具有养血滋阴、润肠通便、截疟、祛风、解毒之功效，用于治疗血虚头昏目眩、心悸、失眠、肝肾阴虚之腰膝酸软、须发早白、耳鸣、遗精；肠燥便秘、久疟体虚、风疹瘙痒、疮痈、瘰疬、痔疮等症；
山茱萸，性味：味酸、性微温，具有补益肝肾、收敛固脱之功效，用于治疗腰头晕目眩、耳聋耳鸣、腰膝酸软、跹精滑精、小便频数、虚汗不止、妇女崩漏等症；
玄参，性味：味甘、苦、咸、性微寒，具有清热凉血、滋阴降火、解毒散结之功效，用于治疗温热病热和营血、身热、烦渴、舌绛、发斑、骨蒸劳嗽、虚烦不寤、津伤便秘、目涩昏花、咽喉喉肿痛、瘰疬痰核、痈疽疮毒等症；
菟丝子，性味：辛甘、平，具有补肾益精、养肝明目、固胎止泄之功效，用于治疗腰膝酸痛、遗精、阳痿、早泄、不育、消渴、淋浊、遗尿、目昏耳鸣、胎动不安、流产、泄泻等症；
白芍，性味：苦、酸、微寒，具有平肝止痛、养血调经、敛阴止汗之功效，用于治疗头痛眩晕、胁痛、腹痛、四肢挛痛、血虚萎黄、月经不调、自汗、盗汗等症；
茯神，性味：甘、淡、性平，具有惊悸、健忘、健忘失眠、惊痫、小便不利之功效，用于治疗惊悸、健忘、健忘失眠、惊痫、小便不利等症；
当归，性味：性温、味甘辛, 具有补血和血、调经止痛、润燥滑肠之功效，用于治疗血虚、面色萎黄、眩晕心悸、血虚、或兼有瘀滞的月经不调、经闭、痛经、虚寒性腹痛、冠心病心绞痛、风湿痹痛、跌打损伤等症；
川芎，性味：辛、温，具有活血行气、祛风止痛之功效，用于治疗月经不调，经闭痛经、症瘕腹痛、胸胁刺痛、跌扑肿痛、头痛、风湿痹痛；
柴胡，性味：苦、微寒，具有和解表里、疏肝、升阳之功效，用于治疗感冒发热、寒热往来、胸胁胀痛、月经不调、子官脱垂、脱肛等症。
本发明药物是基于中医治疗血热生风型斑秃的原则，从依据血热生风型斑秃的病理机制及药理作用认为：就血热生风型斑秃，本发明所提供的药物中的各原料中药药效共奏，对上述疾病有很好的效果。
具体实施方式
本发明就是针对上述血热生风型斑秃的治疗而提出的一种中药配方，采用该配方制备的药物药效好，见效快，是一个标本兼治的中药组方，特别适合临床使用。下面结合本发明的具体实施方式作进一步详细的描述：
实施例1：
一种可有效治疗血热生风型斑秃的汤剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
生地28g、赭石28g、女贞子14g、熟地黄12g、桑葚子12g、丹皮8g、赤芍12g、何首乌20g、山茱萸10g、玄参12g、菟丝子12g、白芍12g、茯神12g、当归14g、川芎10g、柴胡8g。
实施例：
一种可有效治疗血热生风型斑秃的汤剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
生地31g、赭石31g、女贞子16g、熟地黄14g、桑葚子14g、丹皮9g、赤芍13g、何首乌22g、山茱萸11g、玄参14g、菟丝子13g、白芍14g、茯神14g、当归16g、川芎11g、柴胡9g。
实施例3：
一种可有效治疗血热生风型斑秃的汤剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
生地35g、赭石35g、女贞子18g、熟地黄16g、桑葚子16g、丹皮10g、赤芍15g、何首乌25g、山茱萸12g、玄参16g、菟丝子16g、白芍16g、茯神16g、当归18g、川芎12g、柴胡10g。
典型病例
经临床诊断治疗银屑病患者共500例，年龄为39岁以上的320例，只有180例为39岁以下。500例患者中症状逐渐减轻或痊愈的405例，有效的45例，无效的50例。总有效率达90%。
Claims (3)
1.一种可有效治疗血热生风型斑秃的汤剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
生地9～35g、赭石9～35g、女贞子6～18g、熟地黄9～16g、桑葚子10～16g、丹皮6～10g、赤芍6～15g、何首乌10～25g、山茱萸5～12g、玄参9～16g、菟丝子6～16g、白芍6～16g、茯神9～16g、当归8～18g、川芎3～12g、柴胡30～10g。
2.根据权利要求1所述的治疗血热生风型斑秃的汤剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
生地10～31g、赭石10～31g、女贞子7～16g、熟地黄10～14g、桑葚子11～14g、丹皮7～9g、赤芍7～13g、何首乌11～22g、山茱萸6～11g、玄参10～14g、菟丝子7～13g、白芍7～14g、茯神10～14g、当归10～16g、川芎5～11g、柴胡5～9g。
3.根据权利要求1至2所述的治疗血热生风型斑秃的汤剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
生地28g、赭石28g、女贞子14g、熟地黄12g、桑葚子12g、丹皮8g、赤芍12g、何首乌20g、山茱萸10g、玄参12g、菟丝子12g、白芍12g、茯神12g、当归14g、川芎10g、柴胡8g。
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