CN107488172B - Preparation method of afatinib - Google Patents
Preparation method of afatinib Download PDFInfo
- Publication number
- CN107488172B CN107488172B CN201610406782.8A CN201610406782A CN107488172B CN 107488172 B CN107488172 B CN 107488172B CN 201610406782 A CN201610406782 A CN 201610406782A CN 107488172 B CN107488172 B CN 107488172B
- Authority
- CN
- China
- Prior art keywords
- afatinib
- preparation
- reaction
- hydroxytetrahydrofuran
- tert
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
Abstract
Description
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610406782.8A CN107488172B (en) | 2016-06-10 | 2016-06-10 | Preparation method of afatinib |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610406782.8A CN107488172B (en) | 2016-06-10 | 2016-06-10 | Preparation method of afatinib |
Publications (2)
Publication Number | Publication Date |
---|---|
CN107488172A CN107488172A (en) | 2017-12-19 |
CN107488172B true CN107488172B (en) | 2020-06-12 |
Family
ID=60641858
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610406782.8A Active CN107488172B (en) | 2016-06-10 | 2016-06-10 | Preparation method of afatinib |
Country Status (1)
Country | Link |
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CN (1) | CN107488172B (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1867564A (en) * | 2003-10-17 | 2006-11-22 | 贝林格尔·英格海姆国际有限公司 | Process for preparing amino crotonyl compounds |
CN104710413A (en) * | 2013-12-16 | 2015-06-17 | 江苏豪森药业股份有限公司 | Preparation method of afatinib dimaleate |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10221018A1 (en) * | 2002-05-11 | 2003-11-27 | Boehringer Ingelheim Pharma | Use of inhibitors of EGFR-mediated signal transduction for the treatment of benign prostatic hyperplasia (BPH) / prostatic hypertrophy |
-
2016
- 2016-06-10 CN CN201610406782.8A patent/CN107488172B/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1867564A (en) * | 2003-10-17 | 2006-11-22 | 贝林格尔·英格海姆国际有限公司 | Process for preparing amino crotonyl compounds |
CN104710413A (en) * | 2013-12-16 | 2015-06-17 | 江苏豪森药业股份有限公司 | Preparation method of afatinib dimaleate |
Non-Patent Citations (1)
Title |
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"PROCESS FOR THE PREPARATION OF AFATINIB";Disclosed Anonymously;《IP.com Journal》;20150930;第15卷(第10A期);第1-3页 * |
Also Published As
Publication number | Publication date |
---|---|
CN107488172A (en) | 2017-12-19 |
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Legal Events
Date | Code | Title | Description |
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PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A preparation method of afatinib Effective date of registration: 20211224 Granted publication date: 20200612 Pledgee: Industrial and Commercial Bank of China Limited Feixian sub branch Pledgor: SHANDONG NEW TIME PHARMACEUTICAL Co.,Ltd. Registration number: Y2021980016193 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20221028 Granted publication date: 20200612 Pledgee: Industrial and Commercial Bank of China Limited Feixian sub branch Pledgor: SHANDONG NEW TIME PHARMACEUTICAL Co.,Ltd. Registration number: Y2021980016193 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A preparation method of alfatinib Effective date of registration: 20221103 Granted publication date: 20200612 Pledgee: Industrial and Commercial Bank of China Limited Feixian sub branch Pledgor: SHANDONG NEW TIME PHARMACEUTICAL Co.,Ltd. Registration number: Y2022980020531 |