CN107485472A - Biodegradable stent in the treatment paranasal sinusitis is built into nasal sinus road by a device - Google Patents
Biodegradable stent in the treatment paranasal sinusitis is built into nasal sinus road by a device Download PDFInfo
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- CN107485472A CN107485472A CN201710668471.3A CN201710668471A CN107485472A CN 107485472 A CN107485472 A CN 107485472A CN 201710668471 A CN201710668471 A CN 201710668471A CN 107485472 A CN107485472 A CN 107485472A
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- sinus
- support
- nasal
- air bag
- devices
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2/958—Inflatable balloons for placing stents or stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
Abstract
The present invention uses local surfaces anesthesia method, pass through a device, the Biodegradable scaffold that lateral surface is carried to slow releasing pharmaceutical is inserted in the sinus passages of the bilateral mandibular sinus of lesion, bilateral sinus frontalis, bilateral sphenoid sinus, solves the sinus passages drainage problem of paranasal sinus, treats acute and chronic nasal sinusitis.Support inserts initial stage, struts sinus passages surrounding tissue, progressively rebuilds and repairs with the function of sinus, and support in half a year, to 3 years, gradually had no to remain by degraded.Straight tube or bend pipe on the front end sleeve of hard nasal endoscopes, carry Fig. 1 devices and enter in sinus passages, first extract the fester in sinus cavities out, and sinus cavities are rinsed;Now the side wall of sinus passages is because of infiltration decoction congestion and edema regression;The outer overlay film of support is removed, support leading portion and stage casing is opened by air bag, adjusts segment length in support, finally holder back section is opened, completes inserting for drainage stent.
Description
Technical field
The present invention relates to biodegradable drainage stent is inserted into nasal sinus by a device with the method for No operation to lead to
In road, the drainage of unobstructed nasal cavity, paranasal sinus, acute and chronic paranasal sinusitis is treated:Bilateral mandibular sinus, bilateral sinus frontalis and bilateral sphenoid sinus.
Background technology
It is now recognized that the pathogenic factor of paranasal sinusitis causes Dou Kou obstructions to cause in nasal sinus mainly due to a variety of causes
Infection, so the method for treating acute and chronic nasal sinusitis instantly mainly has:1. the nasal cavity locally and systemically nasal sinus sacculus of drug therapy 2.
Dilatation opens the nasal endoscopic surgery removal lesion tissue of sinus passages adequate drainage 3., re-establish nasal cavity, nasal sinus it is good
Ventilation drainage.Above treatment method is all less than optimal, and reason is as follows:A drug therapies are difficult to make sinus passages drainage unobstructed,
Administration time length is caused, part is infected unmanageable;B nasal sinus balloon dilatation wounds are small, can not still be fully solved sinus passages
Drainage problem;Pathological tissues quickly can thoroughly be dispelled adequate drainage by c nasal endoscopic surgeries, but operation is related to face, it is necessary to right
Patient airway, which is intubated, implements general anesthesia processing, brings painful and psychological shade to patient, postoperative nasal cavity is clogged and had certain
Recurrence rate is restricted nasal endoscopic surgery.It is ripe with the research of degradable macromolecule biomaterial, carry drug stent
Appearance, the method can need not perform the operation, using local surfaces anesthesia method, draw with regard to the sinus passages that can reach open paranasal sinus
Flow problem, support insert initial stage, strut sinus passages surrounding tissue, progressively rebuild and repair with the function of sinus, support exists
Half a year, gradually degraded had no to remain to 3 years.It is not required to be in hospital, can not be influenceed incidence CT from institute and nuclear-magnetism is total to after treat-and-release
Shake inspection.
The content of the invention
The purpose of the present invention in order to:Only with the mode of surface anesthesia, carrying device is guided by hard nasal endoscopes, by outside
The biodegradable drainage stent that face carries medicine is put into the sinus passages of paranasal sinus and strutted middle nasal meatus or recessus sphenoethmoidalis, reaches
To the purpose of nasal sinus adequate drainage.
The purpose of the present invention can be achieved through the following technical solutions:
Step A:Fester rinses in sinus cavities
Specific method:First nasal cavity inner surface is anaesthetized with surface anaesthetic, it is hollow straight on the front end card of hard nasal endoscopes
Pipe or bend pipe, Fig. 1 devices are carried, 0 degree or 30 degree of selection is determined by the custom of operator and which specific paranasal sinus for the treatment of
The nasal endoscopes at angle, device insertion straight tube or bend pipe, as nasal endoscopes enter nasal cavity, find sinus frontalis in middle nasal meatus and maxillary sinus are opened
Mouthful, Opening of sphenoid sinus is found at butterfly pharyngeal recess, Fig. 1 is inserted into sinus passages, is advanced slowly, is stopped after having resistance, by Fig. 1 devices
The tail end of hollow tube inner core slightly give forward, connect syringe, extracted out with the fester in syringe holder sinus cavities, connect another note
Emitter, into sinus cavities saline injection rinse, be repeated several times, to extract out intracavity liquid it is limpid, after the completion of inner core slightly to
Outer pumpback.The silk floss material of front end and the outer silk floss coating of overlay film carry anesthesia and corticosteroid medication, anesthesia in Fig. 1 devices
Sinus passages surrounding mucosa and make mucous hyperemia edema extinction.
Step B:Passage is built into Biodegradable stents
The cap for the protection blade being stuck on bar is removed, the blade on exposure bar, by rope by the outside pumpback of overlay film, covered
Splitted in film pumpback by blade, until removing overlay film, remove blade of the hoop on bar, inflated frontal air bag with syringe, prop up
Frame front end is opened in petal specimen page, and device is slightly outwards withdrawn, is affixed front end petal and nasal sinus inwall, with syringe by stage casing gas
Capsule is inflated, and under the observation of nasal endoscopes, is outwards affected 2 guide rods to the right, guide rod is outwards moved right, adjustment support stage casing
Length, stage casing outer rim stop after reaching collar extension, finally by rear end airbag aeration, after support is sufficiently spread out, evacuate in 3 air bags
Fig. 1 devices are taken out after gas.
Sphenoid sinus is because passage is very short, and most of Opening of sphenoid sinus is visible under nasal endoscopes direct-view, and small part is covered by upper concha nasalis media
Lid, support stage casing is shorter, can regular length, be not required to adjust length, be mounted directly sphenoid sinus holder device.
Wait the paranasal sinus High resolution CT image by normal adult person under inspection by force according to dept. of radiology of Beijing Friendship Hospital Li Xiao,
Promoting the circulation of qi body Multi-slice spiral CT on the original image, measure maxillary sinus, sinus frontalis, sphenoid sinus gasification chamber average volume are respectively
17.43ml, 3.42ml, 5.98ml, sinus cavities interior diameter remove the irregular of sinus cavities, diameter is in 1.3mm- in 1.8mm-3.2mm
2.5mm or so, (1) anterior length and the size of support leading portion can probably be estimated in Fig. 1 devices with this.To be warned in practical operation
Cautious nose and nasal sinus anatomical variation, it can be judged by paranasal sinus CT examination.
Biodegradable timbering material is mostly PLA, polyglycolic acid, chitosan, polycaprolactone and some copolymers at present
Such as PLA/polyglycolic acid copolymers, it is special that suitable calorifics, machinery can be obtained by the blending or copolymerization of the two or three
Property and degradation speed support, these high polymer material good biocompatibilities, fully biodegradable, be metabolized as carbon dioxide and
Water.Also magnesium alloy Biodegradable stents may be selected.
The anti-inflammatory drugs steroidal anti-inflammatory drugses such as dexamethasone carried on support and antiproliferative medicine such as taxol, thunder
Pa mycin, slowly discharged for control medicine, it is more at present using carrier of the synthesis high polymer material as medicament slow release.
Brief description of the drawings
Fig. 1 is the structural representation of implementation of the present invention;
Fig. 2 is the partial enlarged drawing of Fig. 1 front ends;
Fig. 3 is the partial enlarged drawing in Fig. 1 stage casings;
Fig. 4 is amplification view of Fig. 1 devices along line A-A;
Fig. 5 is two structural representation of implementation of the present invention;
Fig. 6 is Fig. 5 side view;
Fig. 7 is the expanded view of Fig. 1 carrying Holders;
Embodiment
The present invention is described in detail with reference to the accompanying drawings and detailed description.
First nasal cavity inner surface is anaesthetized with surface anaesthetic, both ends open is non-on the front end card of hard nasal endoscopes (34)
Elastomeric material hollow straight tube (31) or one end are in the bend pipe (30) of 30-45 degree bending, Fig. 1 devices are carried, by the custom of operator
The nasal endoscopes at 0 degree or 30 degree angle of selection, Fig. 1 devices insertion straight tube or bend pipe are determined with which specific paranasal sinus for the treatment of, with
Nasal endoscopes and enter nasal cavity, find sinus frontalis and maxillary sinus opening in middle nasal meatus, find Opening of sphenoid sinus at butterfly pharyngeal recess, Fig. 1 is inserted
Enter sinus passages, be advanced slowly, stop after having resistance, the tail end of the hollow tube (1) in Fig. 1 devices is slightly sent forward, (25) connect
Syringe is connect, is extracted out with the fester in syringe holder sinus cavities, (24) connect another syringe, and physiology salt is injected into sinus cavities
The flushing liquors such as water are rinsed, and are repeated several times, to extract out intracavity liquid it is limpid, after the completion of hollow tube inner core (1) slightly outwards time
Take out.
(2) of front end are made up of the silk floss material of somewhat resilient and are bonded into one with pipeline (4) in Fig. 1 devices, and shape is such as
Hemispherical is bullet-headed, has more than 2 annular shell fragments (3) to be connected with (2) (4) inside it, avoids (2) when passing in and out sinus cavities
Shift or come off into sinus cavities with (4), anesthetic can be carried in (2) and makes the medicine such as Chinese ephedra of nasal mucosa vesselses smooth muscle contraction
Alkali, the outer silk floss coating (10) of overlay film (9) carry the medicine and corticosteroid medication for making nasal mucosa vesselses smooth muscle contraction, make to glue
Film congestion and edema disappears.
The cap (18) for the protection blade (17) being stuck in Fig. 1 gear levers is removed, the blade on exposure bar, passes through rope
(16) by overlay film (9) outside pumpback, splitted in overlay film pumpback by blade, until whole overlay film is removed, exposure support (8), simultaneously
Appear two guide rods (12), (14), remove blade of the hoop on bar, inflated frontal air bag (5) with syringe by (26),
Support front end is opened in petal specimen page in the presence of air bag, and Fig. 1 devices are slightly outwards withdrawn, make front-end bracket and nasal sinus inwall phase
Patch, stage casing air bag (6) is inflated with syringe by (27), under the observation of nasal endoscopes, hold (12), (14) two guide rods
Handle (19), (20) outwards affect to the right 2 guide rods, guide rod is outwards moved right, to adjust the length in support stage casing, stage casing
Outer rim stops after reaching collar extension, inflates rear end air bag (7) finally by (28), back-end support expansion, holder back section is divided to two
Individual petal is opened with upper type, is opened, passed through (26) with reaching concha nasalis media and concha nasalis inferior separation or sphenoid sinus outlet butterfly pharyngeal recess
(27) (28) evacuate the gas in (5), (6), (7) 3 air bags, and 2 guide rods are slightly sent forward, remove the noose of front end, extract branch out
Frame conveying device, complete inserting for support.
Hollow tube (4) in Fig. 2, is separated by cross-section, is formed 3 pipes that internal independence is not communicated with, is made (5) and (26) phase
It is logical, (6) communicated with (27), (7) communicated with (28), and (22 (23) must have enough the air bag (21) in (26), (27), (28)
Toughness and elasticity, it can probably estimate the pressure in (5) (6) (7) air bag.
Fig. 7 support is made up of synthesising biological degraded macromolecular material, the slow-absorbing in sinus passages, absorbs the time limit half
Years -3 years, do not contained except leading portion is connected with the row's S types of back segment the 3rd in such as (41) (42) by biodegradated polymer materal in support
As the slow releasing pharmaceutical of carrier, avoid being broken when S types are connected and deformed, have in remaining S types connection and U-shaped support such as (43) (44)
Anti-inflammatory hyperplasia and suppression connective tissue proliferation drug loading play slow Slow release into biodegradable polymer
Effect.
The U-shaped connection of support is disconnected as (45) (46) (47) (48) in support, so that leading portion is when air bag (5) is inflated
There are 3 and the above is opened in petal specimen page, (49) (50) disconnect the U-shaped connection of support in support, so that back segment is inflated in air bag (7)
When up and down separate.
The both ends of the S connections of stage casing support are connected by rotatable rotating shaft, stage casing when outwards being turned right by (12) (14)
Support can extend, to adapt to the patient of different sinus length.
Claims (9)
1. biodegradable carrying drug stent is inserted nasal sinus sinus and open sinus and drain by one kind reaches treatment acute and chronic nasal sinus
Scorching method, and to complete the therapeutic system that this treatment method uses, it is characterised in that:First with surface anaesthetic by nasal cavity
Surface anesthesia, carry Fig. 1 devices by nasal endoscopes and enter nasal sinus sinus cavities, fester suction and sinus are completed by (1) (24) (25) in Fig. 1
Chamber is rinsed, and nasal sinus road surrounding mucosa congestion and edema is disappeared as the medicine entrained by (2) (10), and table is removed by (16) and (17)
Face overlay film (9), make air bag (5) inflation by (26), leading portion support is in petal opening, and the slightly outside pumpback of device makes
The petal support of leading portion is affixed with sinus mouth inwall, makes air bag (6) inflation by (27), support stage casing is opened, and passes through guide rod
(12) length in (14) adjustment support stage casing, makes air bag (7) inflation by (28), opens holder back section, in reaching
Concha and concha nasalis inferior separation or sphenoid sinus outlet butterfly pharyngeal recess are opened, and the gas in (5) (6) (7) is extracted out by (26) (27) (28),
Extract stent conveying device out, complete inserting for support, can be taken when Fig. 1 devices are sent into sinus cavities by nasal endoscopes using Fig. 5
Band or the direction for changing Fig. 1 devices.
2. according to Fig. 1 devices described in claim 1, it is characterised in that:The front end of pipeline (1) by lateral opening flexible material
Be made, be connected with pipeline below, it is spaced intermediate formation 2 pipelines, end (24) (25) can connect syringe, respectively and
Two pipelines communicate, and suction out the fester in sinus cavities with syringe and injection flushing liquor rinses.
3. according to Fig. 1 devices described in claim 1, it is characterised in that:(2) it is made up of, and carries the silk floss material of somewhat resilient
Topical anesthetic and the medicine for making nasal mucosa vesselses smooth muscle contraction, shape such as hemispherical or bullet-headed, bonded with pipeline (4)
Integrally, 2 more than annular shell fragments are connected with (2) (4) inside it.
4. according to described in claim 1, it is characterised in that:Overlay film 9 is wrapped in outside part (2) and support, surface silk floss coating
(10) carrying makes the medicine and corticosteroid medication of nasal mucosa vesselses smooth muscle contraction.
5. according to described in claim 1, it is characterised in that:Change Fig. 5 devices of Fig. 1 device directions of advance, be both ends open
Hollow tube made of non-elastic material (30), the semicanal of one end are bent in 30-45 degree, the side connection annulus (32) of hollow tube,
It is made up of elastomeric material, another end opening of annulus, annulus can be made to be stuck in securely on nasal endoscopes (34), or is carried and schemed by nasal endoscopes
With (30) and (32), difference is that (31) are hollow straight tubes, only carries and makees for (31) and (33) of 1 device, material and connected mode
With.
6. according to described in claim 1, it is characterised in that:Hollow tube (4) in Fig. 2, is separated by cross-section, forms internal independence not
3 pipes communicated, communicate (5) and (26), and (6) and (27) communicate, and (7) and (28) communicate, and in (26), (27), (28)
(22 (23) must have enough toughness and elasticity to air bag (21), can probably estimate the pressure in (5) (6) (7) air bag.
7. according to described in claim 1, it is characterised in that:Fig. 1 devices enter sinus cavities, after sinus cavities are rinsed, remove blade (17)
Outer protective case (18), with (16) by (9) to recession, splitted in overlay film pumpback by blade, until removing whole overlay film (9), cruelly
There is baffle plate (15) dew support and guide rod (12) (14), support outer end, and guide rod passes through baffle plate.
8. according to described in claim 1, it is characterised in that:Fig. 7 support is made up of synthesizing biological degradable high polymer material,
Slow-absorbing in sinus passages, -3 years half a year of time limit is absorbed, except leading portion connects such as (41) (42) with the row's S types of back segment the 3rd in support
In do not contain by slow releasing pharmaceutical of the biodegradated polymer materal as carrier, in remaining S types connection and U-shaped support such as (43) (44)
There is anti-inflammatory hyperplasia and suppress connective tissue proliferation drug loading into biodegradable polymer, play slow release
The effect of medicine.
9. according to described in claim 8, it is characterised in that:By the U-shaped connection of support as (45) (46) (47) (48) in support
Disconnect, so that leading portion there are 3 when air bag (5) is inflated and above petal specimen page is opened, the both ends of the S connections of stage casing support are by that can turn
Dynamic rotating shaft connection, holder back section (49) (50) disconnects the U-shaped connection of support, so that back segment opens when air bag (7) is inflated.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201710668471.3A CN107485472B (en) | 2017-08-07 | 2017-08-07 | Biodegradable stent leading-in device in nasal sinus |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN201710668471.3A CN107485472B (en) | 2017-08-07 | 2017-08-07 | Biodegradable stent leading-in device in nasal sinus |
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CN107485472A true CN107485472A (en) | 2017-12-19 |
CN107485472B CN107485472B (en) | 2020-07-14 |
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CN201710668471.3A Expired - Fee Related CN107485472B (en) | 2017-08-07 | 2017-08-07 | Biodegradable stent leading-in device in nasal sinus |
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Cited By (1)
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---|---|---|---|---|
CN112074243A (en) * | 2018-03-16 | 2020-12-11 | 阿里内克斯股份有限公司 | System and method for treating nasal cavities |
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